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[PMID]:28478314
[Au] Autor:Demessie Z; Woolfson KN; Yu F; Qu Y; De Luca V
[Ad] Endereço:Department of Biological Sciences, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Canada. Electronic address: Zerihun.Demissie@nrc-cnrc.gc.ca.
[Ti] Título:The ATP binding cassette transporter, VmTPT2/VmABCG1, is involved in export of the monoterpenoid indole alkaloid, vincamine in Vinca minor leaves.
[So] Source:Phytochemistry;140:118-124, 2017 Aug.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vinca minor is a herbaceous plant from the Apocynaceae family known to produce over 50 monoterpene indole alkaloids (MIAs). These include several biologically active MIAs that have a range of pharmaceutical activities. The present study shows that the MIAs, vincamine, akuammicine, minovincinine, lochnericine and vincadifformine tend to be secreted on V. minor leaf surfaces. A secretion mechanism of MIAs, previously described for Catharanthus roseus, appears to be mediated by a member (CrTPT2) of the pleiotropic drug resistance ABC transporter subfamily. The molecular cloning of an MIA transporter (VmTPT2/VmABCG1) that is predominantly expressed in V. minor leaves was functionally characterized in yeast and established it as an MIA efflux transporter. The similar function of VmTPT2/VmABCG1 to CrTPT2 increases the likelihood that this MIA transporter family may have co-evolved within members of Apocynaceae family to secrete selected MIAs and to regulate leaf MIA surface chemistry.
[Mh] Termos MeSH primário: Transportadores de Cassetes de Ligação de ATP/metabolismo
Proteínas de Plantas/metabolismo
Vinca/metabolismo
Vincamina/metabolismo
[Mh] Termos MeSH secundário: Transportadores de Cassetes de Ligação de ATP/genética
Alcaloides
Clonagem Molecular
Alcaloides de Indol
Indóis
Folhas de Planta/metabolismo
Proteínas de Plantas/genética
Vinca/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Indole Alkaloids); 0 (Indoles); 0 (Plant Proteins); 0 (akuammicine); 0 (lochnericine); 3247-10-7 (vincadifformine); 996XVD0JHT (Vincamine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


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[PMID]:28095073
[Au] Autor:Morgan LA; Grundmann O
[Ad] Endereço:a Department of Medicinal Chemistry , College of Pharmacy, University of Florida , Gainesville , FL , USA.
[Ti] Título:Preclinical and Potential Applications of Common Western Herbal Supplements as Complementary Treatment in Parkinson's Disease.
[So] Source:J Diet Suppl;14(4):453-466, 2017 Jul 04.
[Is] ISSN:1939-022X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Parkinson's disease (PD) is a neurological disorder with a complex pathological etiology, which is not fully understood. Progression of PD may be the result of a buildup of iron in the substantia nigra, microglia-mediated neuroinflammation, dysfunctional mitochondria, or abnormal protein handling. Dopamine is the main neurotransmitter affected, but as the disease progresses, a decrease in all the brain's biogenic amines occurs. Current medication used in the treatment of PD aims to prevent the breakdown of dopamine or increase dopaminergic neurotransmission in the central nervous system. The complementary use of green tea (Camellia sinensis), red wine (Vitis vinifera), arctic root (Rhodiola rosea), and dwarf periwinkle (Vinca minor) may have a greater therapeutic effect than current pharmaceutical drugs, such as monoamine oxidase inhibitors or dopamine agonists alone. The bioactive components of these plants have been shown to have neuroprotective, antioxidant, anti-proteinopathies, neural-vasodilation, anti-inflammatory, and iron chelating potential. They may treat the disease at the cellular level by decreasing microglia activation, attenuating damage from radical oxygen species, supporting correct protein folding, chelating iron, increasing the substantia nigra blood flow, and promoting dopaminergic cell growth. Although these alternative medicines appear to have potential, further human clinical trials need to be conducted to determine whether they could have a greater therapeutic effect than conventional medicines alone.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Doença de Parkinson/terapia
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Antioxidantes/uso terapêutico
Encéfalo/metabolismo
Camellia sinensis
Dopamina/metabolismo
Neurônios Dopaminérgicos/metabolismo
Seres Humanos
Quelantes de Ferro/uso terapêutico
Fármacos Neuroprotetores/uso terapêutico
Doença de Parkinson/metabolismo
Rhodiola
Vinca
Vitis
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Iron Chelating Agents); 0 (Neuroprotective Agents); 0 (Plant Preparations); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1080/19390211.2016.1263710


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[PMID]:27967259
[Au] Autor:Feng X; Wang Y; Hao Y; Ma Q; Dai J; Liang Z; Liu Y; Li X; Song Y; Si C
[Ad] Endereço:a Department of Neurology , Affiliated Hospital of Jining Medical University , Jining , Shandong Province , People's Republic of China.
[Ti] Título:Vinpocetine Inhibited the CpG Oligodeoxynucleotide-induced Immune Response in Plasmacytoid Dendritic Cells.
[So] Source:Immunol Invest;46(3):263-273, 2017 Apr.
[Is] ISSN:1532-4311
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plasmacytoid dendritic cells (pDCs) exert dual roles in immune responses through inducing inflammation and maintaining immune tolerance. A switch of pDC phenotype from pro-inflammation to tolerance has therapeutic promise in the treatment of autoimmune diseases. Vinpocetine, a vasoactive vinca alkaloid extracted from the periwinkle plant, has recently emerged as an immunomodulatory agent. In this study, we evaluated the effect of vinpocetine on phenotype of pDCs isolated from C57BL/6 mice and explored its possible mechanism. Our data showed that vinpocetine significantly downregulated the expression of CD40, CD80, and CD86 on pDCs and increased the expression of translocator protein (TSPO), the specific receptor of vinpocetine, in pDCs. Vinpocetine significantly inhibited the Toll-like receptor 9 signaling pathway and reduced the secretion of related cytokines in pDCs through TSPO. Furthermore, viability of pDCs was significantly promoted by vinpocetine. These findings imply that vinpocetine serves as an immunomodulatory agent for pDCs and may be applied for the treatment of pDCs-related autoimmune diseases.
[Mh] Termos MeSH primário: Doenças Autoimunes/tratamento farmacológico
Células Dendríticas/efeitos dos fármacos
Fatores Imunológicos/farmacologia
Alcaloides de Vinca/farmacologia
Vinca/imunologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/efeitos dos fármacos
Células Cultivadas
Ilhas de CpG/genética
Citocinas/metabolismo
Células Dendríticas/imunologia
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Oligodesoxirribonucleotídeos/imunologia
Receptores de GABA/genética
Receptores de GABA/metabolismo
Transdução de Sinais/efeitos dos fármacos
Receptor Toll-Like 9/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bzrp protein, mouse); 0 (Cytokines); 0 (Immunologic Factors); 0 (Oligodeoxyribonucleotides); 0 (Receptors, GABA); 0 (Tlr9 protein, mouse); 0 (Toll-Like Receptor 9); 0 (Vinca Alkaloids); 543512OBTC (vinpocetine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE
[do] DOI:10.1080/08820139.2016.1248561


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[PMID]:27753480
[Au] Autor:Gherbovet O; García Alvarez MC; Bignon J; Roussi F
[Ad] Endereço:Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, UPR 2301 du CNRS, Université Paris-Saclay , 1 Avenue de la Terrasse, 91198, Gif-sur-Yvette Cedex, France.
[Ti] Título:Original Vinca Derivatives: From P-Glycoprotein Substrates to P-Glycoprotein Inhibitors.
[So] Source:J Med Chem;59(23):10774-10780, 2016 Dec 08.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The first example of vinca derivatives 16-18 able to modulate P-glycoprotein (Pgp) efflux activity is reported. They were elaborated in two steps from vinorelbine 3 (VLN) by a modification of the velbenamine moiety. These compounds were able to decrease efficiently Pgp mediated influx and efflux of rhodamine-123 (Rho) and to restore the cytotoxicity of vinorelbine 3 (VLN) and doxorubicin (Dox) on K562R (dox-resistant) cell lines.
[Mh] Termos MeSH primário: Membro 1 da Subfamília B de Cassetes de Ligação de ATP/antagonistas & inibidores
Doxorrubicina/farmacologia
Rodamina 123/farmacologia
Vimblastina/análogos & derivados
Vinca/química
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Relação Dose-Resposta a Droga
Doxorrubicina/química
Doxorrubicina/isolamento & purificação
Seres Humanos
Células K562
Estrutura Molecular
Rodamina 123/química
Rodamina 123/isolamento & purificação
Relação Estrutura-Atividade
Vimblastina/química
Vimblastina/isolamento & purificação
Vimblastina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP-Binding Cassette, Sub-Family B, Member 1); 1N3CZ14C5O (Rhodamine 123); 5V9KLZ54CY (Vinblastine); 80168379AG (Doxorubicin); Q6C979R91Y (vinorelbine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27488659
[Au] Autor:Pérez-López E; Dumonceaux TJ
[Ad] Endereço:1​Instituto de Biotecnología y Ecología Aplicada (INBIOTECA), Universidad Veracruzana, Avenida de Las Culturas Veracruzanas, Xalapa, Veracruz, Mexico.
[Ti] Título:Detection and identification of the heterogeneous novel subgroup 16SrXIII-(A/I)I phytoplasma associated with strawberry green petal disease and Mexican periwinkle virescence.
[So] Source:Int J Syst Evol Microbiol;66(11):4406-4415, 2016 Nov.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytoplasmas (species of the genus 'CandidatusPhytoplasma') are insect-vectored phytopathogenic bacteria associated with economically and ecologically important crop diseases. Strawberry production represents an important part of agricultural activity in Mexico and elsewhere, and infection of plants with phytoplasma renders the fruit inedible by altering plant development, resulting in virescence and phyllody. In this study we examined samples taken from four strawberry plants showing symptoms associated with strawberry green petal disease and from two periwinkle plants showing virescence, sampled in different areas of Mexico. Analysis of the 16S rRNA-encoding sequences showed that the plants were infected with a phytoplasma previously identified as Mexican periwinkle virescence (MPV; 16SrXIII). Examination of bacterial sequences from these samples revealed that two distinct 16S rRNA gene sequences were present in each sample along with a single chaperonin-60 (cpn60) sequence and a single rpoB sequence, suggesting that this strain displays 16S rRNA gene sequence heterogeneity. Two distinct rrn operons, identified with subgroup 16SrXIII-A and the newly described subgroup 16SrXIII-I, were identified from the six samples analyzed, delineating the novel subgroup 16SrXIII-(A/I)I, following the nomenclature proposed for heterogeneous subgroups.
[Mh] Termos MeSH primário: Fragaria/parasitologia
Filogenia
Phytoplasma/classificação
Doenças das Plantas/microbiologia
Vinca/microbiologia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Genes Bacterianos
México
Óperon
Phytoplasma/genética
Phytoplasma/isolamento & purificação
Polimorfismo de Fragmento de Restrição
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160805
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001365


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[PMID]:27239693
[Au] Autor:Green DS
[Ad] Endereço:School of Life Sciences, Gibbet Hill Campus, The University of Warwick, Coventry, United Kingdom; Biogeochemistry Research Group, Geography Department, School of Natural Sciences, Trinity College Dublin, Dublin, Ireland; Queens University Belfast, Marine Laboratory, Portaferry, Northern Ireland, United Kingdom. Electronic address: danniellesgreen@gmail.com.
[Ti] Título:Effects of microplastics on European flat oysters, Ostrea edulis and their associated benthic communities.
[So] Source:Environ Pollut;216:95-103, 2016 Sep.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plastic pollution is recognised as an emerging threat to aquatic ecosystems, with microplastics now the most abundant type of marine debris. Health effects caused by microplastics have been demonstrated at the species level, but impacts on ecological communities remain unknown. In this study, impacts of microplastics on the health and biological functioning of European flat oysters (Ostrea edulis) and on the structure of associated macrofaunal assemblages were assessed in an outdoor mesocosm experiment using intact sediment cores. Biodegradable and conventional microplastics were added at low (0.8 µg L(-1)) and high (80 µg L(-1)) doses in the water column repeatedly for 60 days. Effects on the oysters were minimal, but benthic assemblage structures differed and species richness and the total number of organisms were ∼1.2 and 1.5 times greater in control mesocosms than in those exposed to high doses of microplastics. Notably, abundances of juvenile Littorina sp. (periwinkles) and Idotea balthica (an isopod) were ∼2 and 8 times greater in controls than in mesocosms with the high dose of either type of microplastic. In addition, the biomass of Scrobicularia plana (peppery furrow shell clam) was ∼1.5 times greater in controls than in mesocosms with the high dose of microplastics. This work indicates that repeated exposure to high concentrations of microplastics could alter assemblages in an important marine habitat by reducing the abundance of benthic fauna.
[Mh] Termos MeSH primário: Ecossistema
Ostrea/efeitos dos fármacos
Plásticos/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Biodiversidade
Biomassa
Bivalves/efeitos dos fármacos
Bivalves/fisiologia
Exposição Ambiental/efeitos adversos
Seres Humanos
Isópodes/fisiologia
Ostrea/fisiologia
Plásticos/análise
Água do Mar/química
Testes de Toxicidade
Vinca/efeitos dos fármacos
Vinca/fisiologia
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plastics); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160531
[St] Status:MEDLINE


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[PMID]:26950798
[Au] Autor:Ornano L; Bianco A
[Ad] Endereço:a Dipartimento di Chimica , Università di Roma "La Sapienza" , Roma , Italy.
[Ti] Título:Synthesis of LoganVir, a new carbocyclic nucleoside analogue.
[So] Source:Nat Prod Res;30(19):2164-72, 2016 Oct.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Starting from a natural cyclopentanoid monoterpene belonging to the class of iridoid glucosides called loganin, we performed the synthesis of a new carbocyclic nucleoside, allowing the preparation of a new lead compound, with a potential HIV antiviral activity as an reverse transcriptase competitive inhibitor that we named LoganVir. The stereocontrol of the coupling reaction was completed utilizing the procedure described by Mitsunobu with a purinic base.
[Mh] Termos MeSH primário: Adenosina/análogos & derivados
Fármacos Anti-HIV/síntese química
Ciclopentanos/síntese química
Inibidores da Transcriptase Reversa/síntese química
[Mh] Termos MeSH secundário: Adenosina/síntese química
Fármacos Anti-HIV/farmacologia
Técnicas de Química Sintética
Iridoides/química
Nucleosídeos/química
Nucleosídeos/farmacologia
Inibidores da Transcriptase Reversa/farmacologia
Vinca/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Cyclopentanes); 0 (Iridoids); 0 (LoganVir); 0 (Nucleosides); 0 (Reverse Transcriptase Inhibitors); H7WJ16Q93C (loganin); K72T3FS567 (Adenosine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1149831


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[PMID]:26850347
[Au] Autor:Cheng GG; Zhao HY; Liu L; Zhao YL; Song CW; Gu J; Sun WB; Liu YP; Luo XD
[Ad] Endereço:Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
[Ti] Título:Non-alkaloid constituents of Vinca major.
[So] Source:Chin J Nat Med;14(1):56-60, 2016 Jan.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl (DPPH)-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside (compound 1), together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2 µmol·L(-1), respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.
[Mh] Termos MeSH primário: Glicosídeos Iridoides/isolamento & purificação
Vinca/química
[Mh] Termos MeSH secundário: Antioxidantes/farmacologia
Glicosídeos Iridoides/química
Glicosídeos Iridoides/farmacologia
Folhas de Planta/química
Caules de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Iridoid Glycosides)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160207
[St] Status:MEDLINE


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[PMID]:26700398
[Au] Autor:Zhang ZJ; Du RN; He J; Wu XD; Li Y; Li RT; Zhao QS
[Ad] Endereço:a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming 650500 , China.
[Ti] Título:Three new monoterpenoid indole alkaloids from Vinca major.
[So] Source:J Asian Nat Prod Res;18(4):328-33, 2016.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three new monoterpenoid indole alkaloids, 19-hydroxyl-10-methoxy-19, 20-dihydrovinorine (1), 19-O-acetyl-10-methoxy-19, 20-dihydrovinorine (2), and 19, 21α-dihydroxyl-10-methoxy-19, 20-dihydrovinorine (3), along with five known analogues (4-8), were isolated from the whole plants of Vinca major. The new structures were elucidated by extensive NMR and MS analysis and comparison with known compounds. In addition, compounds 1-3 were evaluated for their cytotoxicities against five human cancer cell lines.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Alcaloides de Triptamina e Secologanina/isolamento & purificação
Vinca/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Seres Humanos
Estrutura Molecular
Alcaloides de Triptamina e Secologanina/química
Alcaloides de Triptamina e Secologanina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (19,21alpha-dihydroxyl-10-methoxy-19,20-dihydrovinorine); 0 (19-O-acetyl-10-methoxy-19, 20-dihydrovinorine); 0 (19-hydroxyl-10-methoxy-19, 20-dihydrovinorine); 0 (Antineoplastic Agents, Phytogenic); 0 (Drugs, Chinese Herbal); 0 (Secologanin Tryptamine Alkaloids)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160329
[Lr] Data última revisão:
160329
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151225
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2015.1094463


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[PMID]:26634841
[Au] Autor:Verma P; Anjum S; Khan SA; Roy S; Odstrcilik J; Mathur AK
[Ad] Endereço:Department of Plant Biotechnology, Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP) Council of Scientific and Industrial Research PO-CIMAP, Lucknow, 226015, India. priyankaurbest@gmail.com.
[Ti] Título:Envisaging the Regulation of Alkaloid Biosynthesis and Associated Growth Kinetics in Hairy Roots of Vinca minor Through the Function of Artificial Neural Network.
[So] Source:Appl Biochem Biotechnol;178(6):1154-66, 2016 Mar.
[Is] ISSN:1559-0291
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Artificial neural network based modeling is a generic approach to understand and correlate different complex parameters of biological systems for improving the desired output. In addition, some new inferences can also be predicted in a shorter time with less cost and labor. As terpenoid indole alkaloid pathway in Vinca minor is very less investigated or elucidated, a strategy of elicitation with hydroxylase and acetyltransferase along with incorporation of various precursors from primary shikimate and secoiridoid pools via simultaneous employment of cyclooxygenase inhibitor was performed in the hairy roots of V. minor. This led to the increment in biomass accumulation, total alkaloid concentration, and vincamine production in selected treatments. The resultant experimental values were correlated with algorithm approaches of artificial neural network that assisted in finding the yield of vincamine, alkaloids, and growth kinetics using number of elicits. The inputs were the hydroxylase/acetyltransferase elicitors and cyclooxygenase inhibitor along with various precursors from shikimate and secoiridoid pools and the outputs were growth index (GI), alkaloids, and vincamine. The approach incorporates two MATLAB codes; GRNN and FFBPNN. Growth kinetic studies revealed that shikimate and tryptophan supplementation triggers biomass accumulation (GI = 440.2 to 540.5); while maximum alkaloid (3.7 % dry wt.) and vincamine production (0.017 ± 0.001 % dry wt.) was obtained on supplementation of secologanin along with tryptophan, naproxen, hydrogen peroxide, and acetic anhydride. The study shows that experimental and predicted values strongly correlate each other. The correlation coefficient for growth index (GI), alkaloids, and vincamine was found to be 0.9997, 0.9980, 0.9511 in GRNN and 0.9725, 0.9444, 0.9422 in FFBPNN, respectively. GRNN provided greater similarity between the target and predicted dataset in comparison to FFBPNN. The findings can provide future insights to calculate growth index, alkaloids, and vincamine in combination to different elicits.
[Mh] Termos MeSH primário: Alcaloides/biossíntese
Redes Neurais (Computação)
Raízes de Plantas/metabolismo
Vinca/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151205
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-015-1935-1



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