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[PMID]:27778313
[Au] Autor:Spigler RB; Theodorou K; Chang SM
[Ad] Endereço:Department of Biology, Temple University, 1900 N. 12th Street, Philadelphia, Pennsylvania, 19122.
[Ti] Título:Inbreeding depression and drift load in small populations at demographic disequilibrium.
[So] Source:Evolution;71(1):81-94, 2017 01.
[Is] ISSN:1558-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inbreeding depression is a major driver of mating system evolution and has critical implications for population viability. Theoretical and empirical attention has been paid to predicting how inbreeding depression varies with population size. Lower inbreeding depression is predicted in small populations at equilibrium, primarily due to higher inbreeding rates facilitating purging and/or fixation of deleterious alleles (drift load), but predictions at demographic and genetic disequilibrium are less clear. In this study, we experimentally evaluate how lifetime inbreeding depression and drift load, estimated by heterosis, vary with census (N ) and effective (estimated as genetic diversity, H ) population size across six populations of the biennial Sabatia angularis as well as present novel models of inbreeding depression and heterosis under varying demographic scenarios at disequilibrium (fragmentation, bottlenecks, disturbances). Our experimental study reveals high average inbreeding depression and heterosis across populations. Across our small sample, heterosis declined with H , as predicted, whereas inbreeding depression did not vary with H and actually decreased with N . Our theoretical results demonstrate that inbreeding depression and heterosis levels can vary widely across populations at disequilibrium despite similar H and highlight that joint demographic and genetic dynamics are key to predicting patterns of genetic load in nonequilibrium systems.
[Mh] Termos MeSH primário: Genética Populacional
Gentianaceae/genética
Vigor Híbrido
Depressão por Endogamia
[Mh] Termos MeSH secundário: Carga Genética
Variação Genética
North Carolina
Densidade Demográfica
South Carolina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/evo.13103


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[PMID]:28288330
[Au] Autor:Lu NH; Zhao HQ; Jing M; Liu X; Ren CZ; Liu XF; Liu JJ; Zhang YX
[Ad] Endereço:Gansu University of Chinese Medicine, Lanzhou 730000, People's Republic of China.
[Ti] Título:The pharmacodynamic active components study of Tibetan medicine Gentianopsis paludosa on ulcerative colitis fibrosis.
[So] Source:Int Immunopharmacol;46:163-169, 2017 May.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The current study focused on the pharmacodynamic activity components of Gentianopsis paludosa against ulcerative colitis (UC) fibrosis including symptoms of intestinal diarrhea and inflammatory. Trinitro-benzene-sulfonic acid induced UC model rats were gavaged with gradient polarity extracts respectively from ethanol-extract of Gentianopsis paludosa. Masson staining and qRT-PCR methods were respectively used to assess the degree of UC fibrosis and detect the mRNA expressions of collagen I, collagen III, a-smooth muscle actin (α-SMA) and E-cadherin in colon tissue. Separated by silica gel column chromatography, further screening was conducted until active components appeared. Infrared, nuclear magnetic resonance, mass spectroscopy and ultraviolet methods were applied to confirm active components' structures. The results indicated that the expression of collagen I, collagen III and α-SMA mRNA in the colon tissues of acetidin group rats was obviously depressed compared with control groups while E-cadherin displayed just opposite. Dyed in blue indicating UC fibrosis degree, the area of acetidin group was less than that other experimental groups. Four components: (1,8-Dihydroxy-3,7-Dimethoxyxanthones, 1-hydroxy-3,7,8-Trimethoxyxanthones, 1,7-Dihydroxy-3,8-Dimethoxyxanthones and 1-hydroxy-3,7-Dimethoxyxanthones), were obtained from acetidin group and all of which have a significant equivalence to Gentianopsis paludosa on the therapeutic effect of UC fibrosis. Our findings revealed the activity components for clinical application history of Gentianopsis paludosa and provided a preliminary foundation for further new drug research and exploitation.
[Mh] Termos MeSH primário: Colite Ulcerativa/tratamento farmacológico
Colo/efeitos dos fármacos
Medicina Tradicional Tibetana
Extratos Vegetais/farmacologia
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
China
Colite Ulcerativa/induzido quimicamente
Colo/patologia
Etanol/química
Fibrose
Gentianaceae/imunologia
Seres Humanos
Extratos Vegetais/química
Ratos
Ratos Wistar
Ácido Trinitrobenzenossulfônico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Xanthones); 3K9958V90M (Ethanol); 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:28278647
[Au] Autor:Wang H; Yuan X; Huang H; Zhang B; Cao C; Zhao HP
[Ad] Endereço:a Institute of Chemical Engineering , Qinghai University , Xining , China.
[Ti] Título:Chemical constituents from Swertia mussotii Franch. (Gentianaceae).
[So] Source:Nat Prod Res;31(14):1704-1708, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chemical investigation of ethanolic extract from Swertia mussotii Franch. has resulted in the isolation of 11 compounds which were identified as Orcinol-ß-D-glucoside (1), Shamimin (2), Mangiferin (3), Decussatin (4), Bellidifolin (5), Desmethylbellidifolin (6), Protocatechuic acid (7), 1,7-Dihydroxy-3,8-dimethoxyxanthone (8), 1,8-Dihydroxy-3,5-dimethoxyxanthone (9), 1-Hydroxy-3,5-dimethoxyxanthone (10), Telephioidin (11). The chemical structures of these compounds were identified by a combination of spectroscopic analysis and a comparison with those reported in literature. Among them, compounds 1, 2, 7 and 11 were isolated from the genus Swertia for the first time. Moreover, the chemotaxonomic significance of these compounds was summarised. The chemotaxonomic study suggests that there is a close chemotaxonomic relationship between S. mussotii and other species of Swertia, such as S. punicea, S. macrosperma, S. japonica, S. phragmitiphylla, S. chirayita, S. cordata and S. binchuanensis, with presence of compounds 3~6, 8~10. The xanthones and their glycosides may sever as important chemotaxonomic markers of Swertia genus.
[Mh] Termos MeSH primário: Swertia/química
[Mh] Termos MeSH secundário: Classificação/métodos
Gentianaceae/química
Glicosídeos/análise
Glicosídeos/isolamento & purificação
Xantonas/análise
Xantonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Xanthones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1286480


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[PMID]:28062510
[Au] Autor:Spigler RB
[Ad] Endereço:Department of Biology, Temple University, 1900 N. 12th Street, Philadelphia, PA 19122, USA rachel.spigler@temple.edu.
[Ti] Título:Plasticity of floral longevity and floral display in the self-compatible biennial Sabatia angularis (Gentianaceae): untangling the role of multiple components of pollination.
[So] Source:Ann Bot;119(1):167-176, 2017 Jan.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Plasticity of floral traits in response to pollination can enable plants to maximize opportunities for pollen import and export under poor pollination conditions, while minimizing costs under favourable ones. Both floral longevity and display are key traits influencing pollination. While pollination-induced flower wilting is widely documented, we lack an understanding of the multifactorial complexity of this response, including the influence of other pollination components, costs of extended longevity and subsequent impacts on floral display. METHODS: Plasticity of floral longevity was experimentally evaluated in Sabatia angularis in response to multiple pollination factors: pollen addition, removal, and source (self, single-donor outcross, multiple-donor outcross) and timing of pollination. Effects of pollen quantity were further evaluated by exploiting variation in autonomous self-pollen deposition. Delayed pollination costs were tested comparing seed set from early versus late pollinations. Finally, I compared floral display metrics (peak floral display, time to peak flower, flowering duration, mean flowering rate) between experimentally pollinated and control plants. KEY RESULTS: Floral longevity was highly plastic in response to pollen addition and its timing, and the response was dose-dependent but insensitive to pollen source. Pollen removal tended to extend floral longevity, but only insofar as it precluded pollination-induced wilting via autonomous self-pollination. Under delayed pollination, the wilting response was faster and no cost was detected. Pollination further led to reduced peak floral displays and condensed flowering periods. CONCLUSIONS: Floral longevity and display plasticity could optimize fitness in S. angularis, a species prone to pollen limitation and high inbreeding depression. Under pollinator scarcity, extended floral longevities offer greater opportunities for pollen receipt and export at no cost to seed set, reproductive assurance via autonomous self-pollination and larger, more attractive floral displays. Under high pollinator availability, shortened longevities lead to smaller displays that should lower the risk of geitonogamy.
[Mh] Termos MeSH primário: Flores/fisiologia
Gentianaceae/fisiologia
Polinização/fisiologia
[Mh] Termos MeSH secundário: Cruzamentos Genéticos
Flores/anatomia & histologia
Gentianaceae/anatomia & histologia
Autoincompatibilidade em Angiospermas/fisiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcw195


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[PMID]:27640952
[Au] Autor:Calió MF; Lepis KB; Pirani JR; Struwe L
[Ad] Endereço:Universidade de São Paulo, Instituto de Biociências, Departamento de Botânica, Rua do Matão, 277, CEP: 05508-090 São Paulo, SP, Brazil. Electronic address: mfecalio@unicamp.br.
[Ti] Título:Phylogeny of Helieae (Gentianaceae): Resolving taxonomic chaos in a Neotropical clade.
[So] Source:Mol Phylogenet Evol;106:192-208, 2017 Jan.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The monophyletic and Neotropical tribe Helieae of the worldwide family Gentianaceae (Gentianales, Asterids, Angiospermae) is well known for its problematic generic classifications. An initial phylogenetic analysis of Helieae shed light onto the relationships between genera, and indicated that traditional generic limits did not correspond to monophyletic groups. In order to obtain a more thorough understanding of generic relationships within the group, we enhanced sampling within the so-called Symbolanthus clade and performed phylogenetic analyses from DNA sequences from one plastid region (matK) and two nuclear regions (ITS and 5S-NTS), plus 112 morphological characters, which were analyzed separately and in combination, using parsimony and Bayesian approaches. A total of 83 individuals representing 20 genera and 51 species of Helieae were sampled; 13 species were included in this study solely based on their morphological characters. Ancestral character reconstructions were performed to identify potential synapomorphies of clades and patterns of homoplasy in the morphological dataset. Our results demonstrate that Prepusa is sister to the remainder of Helieae. Furthermore, the Macrocarpaea clade, the Irlbachia clade and the Symbolanthus clade were also recovered. Within the Symbolanthus clade, our results confirm that Calolisianthus and Chelonanthus are not monophyletic, and also contest the monophyly of Irlbachia as currently circumscribed. Specifically, two species of Calolisianthus group with the type species of Chelonanthus, while the other Calolisianthus species are more closely related to Tetrapollinia and Symbolanthus. Moreover, the green-white-flowered Chelonanthus species and Adenolisianthus are undoubtedly related to Helia and several analyses support Irlbachia pratensis as more closely related to the lineage including the type species of Chelonanthus described above The addition of new characters and taxa led to higher confidence in the relative position of some clades, as well as provided further support for a new generic circumscription of Calolisianthus, Chelonanthus, and Helia. Even though several morphological characters traditionally used in the taxonomy of the group were shown to be homoplasious, most clades can be diagnosed by a combination of morphological character states.
[Mh] Termos MeSH primário: Gentianaceae/classificação
[Mh] Termos MeSH secundário: Teorema de Bayes
DNA de Plantas/química
DNA de Plantas/isolamento & purificação
DNA de Plantas/metabolismo
Bases de Dados Genéticas
Flores/genética
Gentianaceae/genética
Filogenia
Plastídeos/genética
RNA Ribossômico 5S/classificação
RNA Ribossômico 5S/genética
RNA Ribossômico 5S/metabolismo
Alinhamento de Sequência
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (RNA, Ribosomal, 5S)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160920
[St] Status:MEDLINE


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[PMID]:28480366
[Au] Autor:Zhang D; Jiang B; Duan L; Zhou N
[Ad] Endereço:College of pharmacy and chemistry, Dali University, Dali, Yunnan 671000, PR China.
[Ti] Título:INTERNAL TRANSCRIBED SPACER (ITS), AN IDEAL DNA BARCODE FOR SPECIES DISCRIMINATION IN CRAWFURDIA WALL. (GENTIANACEAE).
[So] Source:Afr J Tradit Complement Altern Med;13(6):101-106, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: DNA barcoding is a technique used to identify species based on species-specific differences in short regions of their DNA. It is widely used in species discrimination of medicinal plants and traditional medicines. MATERIALS AND METHODS: In the present study, four potential DNA barcodes, namely , , and ITS (nuclear ribosomal internal transcribed spacer) were adopted for species discrimination in Wall (Genetiaceae). Identification ability of these DNA barcodes and combinations were evaluated using three classic methods (Distance, Blast and Tree-Building). RESULTS: As a result, ITS, and regions showed great universality for a success rate of 100%; whereas matK was disappointing for which only 65% samples gained useful DNA sequences. ITS region, which could clearly and effectively identify the five species in , performed very well in this study. On the contrary, and performed poorly in discrimination among these species. CONCLUSION: ITS marker was an ideal DNA barcode in and it should be incorporated into one of the core barcodes for seed plants.
[Mh] Termos MeSH primário: Código de Barras de DNA Taxonômico/métodos
DNA Espaçador Ribossômico/genética
Gentianaceae/genética
[Mh] Termos MeSH secundário: Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal Spacer)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i6.15


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[PMID]:27823623
[Au] Autor:Yu Y; Yi XJ; Mei ZY; Li J; Huang XJ; Yang GZ; Ma LQ; Gao Y
[Ad] Endereço:College of Pharmacy, South-Central University for Nationalities, Wuhan, 430074, PR China.
[Ti] Título:The water extract of Veratrilla baillonii could attenuate the subacute toxicity induced by Aconitum brachypodum.
[So] Source:Phytomedicine;23(13):1591-1598, 2016 Dec 01.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aconitum brachypodum Diels (Family Ranunculaceae) is a Chinese ethnodrug and is well known for both its therapeutic application and high toxicity. However, no detoxication strategy is available for the complete elimination of the toxicity of Aconitum plants. Veratrilla baillonii Franch is believed to possess antitoxic effects on the toxicity induced by Aconitum plants and has been clinically used for hundreds of time by Naxi and Lisu nationalities in Yunnan Province of China. To further address the mechanism of the detoxication of Veratrilla baillonii, the effect of water decoction of Veratrilla baillonii (WVBF) on subacute toxicology of SD rats induced by Aconitum brachypodum (CFA), a genus Aconitum, was determined and studied in the present work. METHODS: The clinical behavior and number of survivors for different dosage of WVBF (25, 50, 100mg/kg) on CFA (4mg/kg) induced rats were observed until day 28. Histological changes and haematological parameters were evaluated. Moreover, Na -K -ATPase pathway in heart as well as key enzymes in liver were determined to further discuss the mechanism. RESULTS: The results showed that the exposure of CFA led to some subacute toxicity to rats, especially male ones, accompanied with abnormality of serum biochemical index in rats' serum. The toxicological target organs of CFA may be the heart, liver, kidney and brain. It is demonstrated that WVBF could attenuate the toxicity induced by Aconitum brachypodum via promoting the metabolic enzymes CYP3A1 and CYP3A2 in liver, downregulating the expression of Sodium/Calcium exchanger 1 (NCX1) and SCN5A sodium channal mRNA, and inducing Na /K -ATPase activity in heart. This study provides insights into detoxifying measures of Aconitum plants. CONCLUSIONS: Aconitum brachypodum may lead to subacute toxicity of rats after long term of administration, and the toxicity could be attenuated by Veratrilla baillonii via promoting the metabolic enzymes in liver, downregulating the expression of NCX1 and SCN5A mRNA, and inducing Na /K -ATPase activity in heart.
[Mh] Termos MeSH primário: Aconitum/toxicidade
Gentianaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
China
Citocromo P-450 CYP3A/metabolismo
Regulação para Baixo/efeitos dos fármacos
Feminino
Coração/efeitos dos fármacos
Inativação Metabólica/efeitos dos fármacos
Rim/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Medicina Tradicional Chinesa
Ratos Sprague-Dawley
Trocador de Sódio e Cálcio/metabolismo
ATPase Trocadora de Sódio-Potássio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Sodium-Calcium Exchanger); 0 (sodium-calcium exchanger 1); EC 1.14.14.1 (Cyp3a1 protein, rat); EC 1.14.14.1 (Cyp3a2 protein, rat); EC 1.14.14.1 (Cytochrome P-450 CYP3A); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


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[PMID]:27780133
[Au] Autor:Leong XY; Thanikachalam PV; Pandey M; Ramamurthy S
[Ad] Endereço:School of Pharmacy, International Medical University, Bukit Jalil- 57000, Malaysia.
[Ti] Título:A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases.
[So] Source:Biomed Pharmacother;84:1051-1060, 2016 Dec.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Swertiamarin, is a secoiridoid glycoside found in genera of Enicostemma Species (Enicostemma littorale and Enicostemma axillare) belonging to the family of gentianaceae, which has been reported to cure many diseases such as diabetes, hypertension, atherosclerosis, arthritis, malaria and abdominal ulcers. However, to the best of our knowledge, till date systematic studies to understand the molecular basis of cardiac and metabolic disease preventing properties of swertiamarin has not been reported. AIM OF THE REVIEW: The present review aims to compile an up-to-date information on the progress made in the protective role of swertiamarin in cardiac and metabolic diseases with the objective of providing a guide for future research on this bioactive molecule. MATERIALS AND METHODS: Information on the swertiamarin was collected from major scientific databases (Pubmed, Springer, google scholar, and Web of Science) for publication between1974-2016. In this review, the protective role of swertiamarin on cardiac and metabolic diseases was discussed. RESULTS: Swertiamarin reported to exhibit a wide range of biological activities such as anti-atherosclerotic, antidiabetic, anti-inflammatory and antioxidant effects. These activities were mainly due to its effect on various signaling pathways associated with cardiac remodeling events such as inhibition of NF-kB expression, LDL oxidation, apoptosis, inflammatory and lipid peroxidation markers and stimulation of antioxidant enzymes. CONCLUSION: Sweriamarin exhibit a wide range of biological activities. This review presents evidence supporting the point of view that swertiamarin should be considered a potential therapeutic agent against cardiac and metabolic diseases, giving rise to novel applications in their prevention and treatment.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Doenças Cardiovasculares/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Glucosídeos Iridoides/uso terapêutico
Doenças Metabólicas/tratamento farmacológico
Pironas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/efeitos adversos
Anti-Inflamatórios/farmacocinética
Antioxidantes/efeitos adversos
Antioxidantes/farmacocinética
Gentianaceae
Seres Humanos
Hipoglicemiantes/efeitos adversos
Hipoglicemiantes/farmacocinética
Glucosídeos Iridoides/efeitos adversos
Glucosídeos Iridoides/farmacocinética
Fitoterapia
Plantas Medicinais
Pironas/efeitos adversos
Pironas/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Hypoglycemic Agents); 0 (Iridoid Glucosides); 0 (Pyrones); 4038595T7Y (swertiamarin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:27390352
[Au] Autor:Betzin A; Thiv M; Koch MA
[Ad] Endereço:Department of Plant Systematics and Biodiversity, Centre for Organismal Studies (COS) Heidelberg, Heidelberg University, D-69120 Heidelberg, Germany.
[Ti] Título:Diversity hotspots of the laurel forest on Tenerife, Canary Islands: a phylogeographic study of Laurus and Ixanthus.
[So] Source:Ann Bot;118(3):495-510, 2016 Sep.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Macaronesian laurel forest is among the worldwide hotspots of threatened biodiversity. With increasing evidence that woodland composition on the Canary Islands changed dramatically during the last few thousand years, the aim of this study was to find evidence for substantial recent population dynamics of two representative species from laurel forest. METHODS: Amplified fragment length polymorphism (AFLP) was used to evaluate fine-scaled genetic variation of the paradigmatic tree Laurus novocanariensis (Lauraceae) and a long-lived herbaceous gentian from core laurel forest, Ixanthus viscosus (Gentianaceae), on Tenerife. Bioclimatic variables were analysed to study the respective climate niches. A chloroplast DNA screening was performed to evaluate additional genetic variation. KEY RESULTS: Genetic diversity of the laurel tree showed severe geographic partitioning. On Tenerife, fine-scaled Bayesian clustering of genetic variation revealed a western and an eastern gene pool, separated by a zone of high admixture and with a third major gene pool. Compared with genetic clusters found on the other Canary Islands, the East-West differentiation on Tenerife seems to be more recent than differentiation between islands. This is substantiated by the finding of extremly low levels of chloroplast DNA-based polymorphisms. Ixanthus showed no geographic structuring of genetic variation. CONCLUSIONS: Genetic data from Tenerife indicate contemporary gene flow and dispersal on a micro/local scale rather than reflecting an old and relic woodland history. In particular for Laurus, it is shown that this species occupies a broad bioclimatic niche. This is not correlated with its respective distribution of genetic variation, therefore indicating its large potential for contemporary rapid and effective colonization. Ixanthus is more specialized to humid conditions and is mostly found in the natural Monteverde húmedo vegetation types, but even for this species indications for long-term persistence in the respective bioclimatically differentiated regions was not find.
[Mh] Termos MeSH primário: Variação Genética
Gentianaceae/genética
Laurus/genética
[Mh] Termos MeSH secundário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Teorema de Bayes
DNA de Cloroplastos/genética
Florestas
Fluxo Gênico
Filogeografia
Polimorfismo Genético
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcw124


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[PMID]:27367721
[Au] Autor:Gold-Smith F; Fernandez A; Bishop K
[Ad] Endereço:Auckland Cancer Society Research Center, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. fgol315@aucklanduni.ac.nz.
[Ti] Título:Mangiferin and Cancer: Mechanisms of Action.
[So] Source:Nutrients;8(7), 2016 Jun 28.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Mangiferin, a bioactive compound derived primarily from Anacardiaceae and Gentianaceae families and found in mangoes and honeybush tea, has been extensively studied for its therapeutic properties. Mangiferin has shown promising chemotherapeutic and chemopreventative potential. This review focuses on the effect of mangiferin on: (1) inflammation, with respect to NFκB, PPARÒ¯ and the immune system; (2) cell cycle, the MAPK pathway G2/M checkpoint; (3) proliferation and metastasis, and implications on ß-catenin, MMPs, EMT, angiogenesis and tumour volume; (4) apoptosis, with a focus on Bax/Bcl ratios, intrinsic/extrinsic apoptotic pathways and telomerase activity; (5) oxidative stress, through Nrf2/ARE signalling, ROS elimination and catalase activity; and (6) efficacy of chemotherapeutic agents, such as oxaliplatin, etoposide and doxorubicin. In addition, the need to enhance the bioavailability and delivery of mangiferin are briefly addressed, as well as the potential for toxicity.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Anacardiaceae/química
Animais
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Modelos Animais de Doenças
Sinergismo Farmacológico
Gentianaceae/química
Seres Humanos
Inflamação/tratamento farmacológico
Metástase Neoplásica
Estresse Oxidativo
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Testes de Toxicidade
Xantonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); 0 (Xanthones); 1M84LD0UMD (mangiferin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE



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