Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.456.750.492 [Categoria DeCS]
Referências encontradas : 21 [refinar]
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  1 / 21 MEDLINE  
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[PMID]:27514655
[Au] Autor:Liu Y; Ni Y; Ruan J; Qu L; Yu H; Han L; Zhang Y; Wang T
[Ad] Endereço:Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
[Ti] Título:Bioactive gentixanthone and gentichromone from the whole plants of Gentianella acuta (Michx.) Hulten.
[So] Source:Fitoterapia;113:164-9, 2016 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new compounds, gentixanthones A1 (1), A2 (2), and gentichromones A1-A3 (3-5), together with thirteen known xanthones (6-18) were obtained from the whole plants of Gentianella acuta (Michx.) Hulten. Their structures were elucidated by chemical and spectroscopic methods. Among them, compounds 6, 8, 13, 14, and 17 were obtained from Gentianella genus firstly, and 7, 12, 15, 16, and 18 were isolated from this plant for the first time. Meanwhile, inhibitory effects of 1-18 on motility of mouse isolated intestine tissue were determined. As results, xanthones 1, 2, 6, 7, 9, 10 and 14 were found to have significant reduce effect on intestine contraction tension, and structure-activity relationship was discussed.
[Mh] Termos MeSH primário: Gentianella/química
Intestinos/efeitos dos fármacos
Peristaltismo/efeitos dos fármacos
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Técnicas In Vitro
Camundongos
Estrutura Molecular
Relação Estrutura-Atividade
Xantonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Xanthones)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE


  2 / 21 MEDLINE  
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[PMID]:27306440
[Au] Autor:Lu S; Tanaka N; Kawazoe K; Murakami K; Damdinjav D; Dorjbal E; Kashiwada Y
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
[Ti] Título:Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp. acuta.
[So] Source:J Nat Med;70(4):780-8, 2016 Oct.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Two tetrahydroxanthones, 1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (1) and 1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (2), and six new tetrahydroxanthone glycosides, amarellins A-F (3-8), were isolated from the aerial parts of a Mongolian medicinal plant Gentianella amarella ssp. acuta (Gentianaceae). The structures of 1-8 were elucidated on the basis of spectroscopic analysis, chemical conversion, and ECD calculation. Amarellins A-C (3-5) were assigned as 8-O-ß-D-glucoside, 8-O-ß-D-xyloside, and 1-O-ß-D-glucoside of 1, respectively, while amarellins D-F (6-8) were elucidated to be 8-O-ß-D-xyloside, 1-O-ß-D-glucoside, and 3-O-ß-D-glucoside of 2, respectively.
[Mh] Termos MeSH primário: Gentianella/química
Glucosídeos/isolamento & purificação
Glicosídeos/isolamento & purificação
Extratos Vegetais/química
Xantonas/isolamento & purificação
[Mh] Termos MeSH secundário: Gentianaceae/química
Glucosídeos/química
Glicosídeos/química
Estrutura Molecular
Mongólia
Componentes Aéreos da Planta
Plantas Medicinais/química
Xantonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucosides); 0 (Glycosides); 0 (Plant Extracts); 0 (Xanthones); 0 (xylosides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-016-1015-z


  3 / 21 MEDLINE  
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[PMID]:26031436
[Au] Autor:Plenk K; Göd F; Kriechbaum M; Kropf M
[Ad] Endereço:Institute for Integrative Nature Conservation Research, University of Natural Resources and Life Sciences, Vienna, Austria.
[Ti] Título:Genetic and reproductive characterisation of seasonal flowering morphs of Gentianella bohemica revealed strong reproductive isolation and possible single origin.
[So] Source:Plant Biol (Stuttg);18(1):111-23, 2016 Jan.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phenotypic polymorphism represents the most obvious type of intraspecific diversity raising scientific interest in its evolution and maintenance. We studied the regional endemic Gentianella bohemica, which exhibits an early- and a late-flowering morph. Genetic variation and structuring were investigated in relation to potential pollination and mating system differences, to verify hypotheses of evolutionary integrity, origin, and reproductive isolation of both flowering morphs. We identified the rarer early-flowering morph as an independent genetic entity, being more selfing, likely stronger pollinator-limited and reproductively isolated. All analysed populations showed strong among population differentiation and low overall genetic diversity due to habitat fragmentation and reduced population sizes. These results indicate likely inbreeding, but we also found evidence for possible outbreeding depression in the late-flowering morph. Both G. bohemica morphs are characteristic of traditionally used, nutrient-poor grasslands, but they represent independent conservation units and need temporally adapted management. We, therefore, also briefly discuss our results in the general context of conservation activities in relation to intraspecific polymorphisms and strongly argue for their formal and consequent consideration.
[Mh] Termos MeSH primário: Variação Genética
Gentianella/fisiologia
Isolamento Reprodutivo
[Mh] Termos MeSH secundário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Áustria
Ecossistema
Flores/genética
Genética Populacional
Gentianella/genética
Endogamia
Polinização
Densidade Demográfica
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150603
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12354


  4 / 21 MEDLINE  
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[PMID]:26297839
[Au] Autor:Wang Z; Wu Q; Yu Y; Yang C; Jiang H; Wang Q; Yang B; Kuang H
[Ad] Endereço:Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 08854, USA.
[Ti] Título:Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC-ESI-MS/MS.
[So] Source:J Ethnopharmacol;174:261-9, 2015 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Gentianella acuta (Michx.) Hulten belonging to the family of Gentianaceae is an annual plant mainly distributed in north of China, Mongolia plateau, Siberia and Far East areas of Russia. The whole herb was used as folk medicine to treat hepatitis, jaundice, headache and fever in Mongolia native medicine. Xanthones are the main active compounds of G. acuta and possess a lot of pharmacological and biological activities AIM OF THE STUDY: A selective and sensitive UHPLC-MS/MS method was developed and validated for the determination and pharmacokinetic study of swertianolin, norswertianolin, bellidifolin and demethylbellidifolin (DMB) in rat plasma after oral administration of G. acuta extract. MATERIALS AND METHODS: Sample preparation involved a liquid-liquid extraction of the analytes with ethyl acetate. Butylparaben was employed as an internal standard. LC separation was achieved on an Agilent SB-C18 RRHD column (1.8 µm, 150 mm × 2.1 mm) at 30°C with an isocratic mobile phase consisting of acetonitrile-water (0.1% formic acid) (90:10, v/v). The detection was accomplished by multiple-reaction monitoring (MRM) scanning with electrospray ionization (ESI) source operating in the negative ionization mode. The optimized mass transition ion-pairs (m/z) monitored for swertianolin, norswertianolin, bellidifolin, DMB and I.S. were 435.1/272.0, 420.8/258.9, 273.0/258.0, 258.9/214.9 and 193.0/92.0, respectively. RESULTS: The current UHPLC-MS/MS assay was validated for linearity, intra-day and inter-day precisions, accuracy, extraction recovery and stability and was suitable for pharmacokinetic studies of the four xanthones after oral administration of G. acuta extract. The time to reach the maximum plasma concentration (Tmax) was 0.40 ± 0.12 h for swertianolin, 0.27 ± 0.07 h for norswertianolin, 1.00 ± 0.18 h for bellidifolin and 0.94 ± 0.15 h for demethylbellidifolin. The elimination half-time (t1/2) of swertianolin, norswertianolin, bellidifolin and DMB, was 19.7 ± 9.64 h, 11.3 ± 4.51 h, 19.9 ± 8.11 h and 24.9 ± 8.19 h, respectively. CONCLUSION: This study described a simple, sensitive and validated UHPLC-MS/MS method for simultaneous determination of four xanthones in rat plasma after oral administration of G. acuta extract, and investigated on their pharmacokinetic studies as well.
[Mh] Termos MeSH primário: Gentianella
Extratos Vegetais/sangue
Extratos Vegetais/farmacocinética
Espectrometria de Massas por Ionização por Electrospray/métodos
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Cromatografia Líquida de Alta Pressão/métodos
Masculino
Extratos Vegetais/administração & dosagem
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151106
[Lr] Data última revisão:
151106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150823
[St] Status:MEDLINE


  5 / 21 MEDLINE  
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[PMID]:26087537
[Au] Autor:Lv Y; Zhang HT; Wang YF; Zhu H; Long P; Wang ZW; Zhang N; Zhang CH
[Ti] Título:[Preliminary comparative study of swertiamarin and swertisin on three kinds of Digeda-species Mongolian medicinal materials].
[So] Source:Zhongguo Zhong Yao Za Zhi;40(5):804-6, 2015 Mar.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Lomatogonium rotatum (L.) Fries, Gentianopsis barbata (Froel) Ma, and Gentianella acuta (Michx.) Hulten, the three kinds of Digeda-species Mongolian medicinal materials belonging to the family Gentianaceae, bad been widely used for the treatment of liver diseases. To analyze comparatively the content of swertiamarin and swertisin among these three kinds of Digeda-species Mongolian medicinal materials. HPLC method was applied for qualitative and quantitative analysis of swertiamarin and swertisin. The Phenomenex C18 (4.6 mm x 250 mm, 5 µm) was used, chromatographic methanol and water as mobile phase, the flow rate was 1.5 mL x min(-1) with UV detected at 237 nm, column oven temperature was 25 degrees C. Results showed that the contents of swertiamarin and swertisin were closely related the different species and producing areas. The content range of swertiamarin in L. rotatum from different habitats was 1.73% - 2.72%, 0.43% - 0.96% for the swertisin content; the content of swertiamarin in G. barbata from Alxa Left Banner was 0.38%, and the content of swertiamarin and swertisin in G. barbata from the others habitats and G. Acuta from different habitats were all detected qualitatively. The contents of swertiamarin and swertisin among these medicinal plants showed a significant difference due to the different species and producing areas. As a consequence, these medicinal plants should not be put together for clinical applications.
[Mh] Termos MeSH primário: Apigenina/análise
Gentianaceae/química
Glucosídeos Iridoides/análise
Extratos Vegetais/análise
Pironas/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Gentianaceae/classificação
Gentianella/química
Gentianella/classificação
Medicina Tradicional da Mongólia
Mongólia
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Iridoid Glucosides); 0 (Plant Extracts); 0 (Pyrones); 0 (swertisin); 4038595T7Y (swertiamarin); 7V515PI7F6 (Apigenin)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150620
[St] Status:MEDLINE


  6 / 21 MEDLINE  
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[PMID]:25442320
[Au] Autor:Huang YJ; Lu H; Yu XL; Song WB; Zhang SW; Fen LY; Xuan LJ
[Ad] Endereço:State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
[Ti] Título:Anti-inflammatory secoiridoid glycosides from Gentianella azurea.
[So] Source:Bioorg Med Chem Lett;24(22):5260-4, 2014 Nov 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation on crude extract of Gentianella azurea led to the isolation of ten new (1-10) and one known (11) secoiridoid glycosides. Their structures were unambiguously elucidated by analysis of 1D and 2D NMR. Compounds 2, 5 and 11 were found to inhibit nitric oxide (NO) production in RAW 264.7 macrophages with IC50 values of 52.78 ± 8.61, 0.69 ± 0.23 and 5.18 ± 1.33, respectively, while indomethacin, the positive control, showed an IC50 value of 1.25 ± 0.52 µM.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Gentianella/química
Glicosídeos Iridoides/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Linhagem Celular
Gentianella/metabolismo
Seres Humanos
Glicosídeos Iridoides/isolamento & purificação
Glicosídeos Iridoides/farmacologia
Macrófagos/citologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Espectroscopia de Ressonância Magnética
Camundongos
Conformação Molecular
Óxido Nítrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Iridoid Glycosides); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


  7 / 21 MEDLINE  
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[PMID]:25335286
[Au] Autor:Wang ZB; Zhai YD; Yu Y; Song PY; Wang QH; Yang BY; Kuang HX
[Ti] Título:[Study on lignans of Gentianella acuta].
[So] Source:Zhong Yao Cai;37(5):800-3, 2014 May.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the lignans from the whole plant of Gentianella acuta. METHODS: The compounds were isolated by various chromatographic techniques and indentified by spectroscopic methods. RESULTS: Nine compounds were isolated and identified as (7R,8S) -dehydrodiconiferyl alcohol-4,9'-O-beta-D-glucopyranoside (1), alaschanisoside A (2), citrusin A (3), olivil-4'-O-beta-D-glucopyranoside (4), leptolepisol D (5), acanthoside D (6), (+) pinoresinol-4-O-beta-D-glucopyranoside (7), (+) 8-hydroxypinoresinol-4-O-beta-D-glucopyranoside (8), and (+) pinoresinol-8-O-beta-D-glucopyranoside (9). CONCLUSION: Compounds 1 - 9 are isolated from this plant for the first time, compounds 1 and 9 are isolated from Gentianella genus for the first time,and compounds 2, 3 and 5 - 8 are isolated from Gentianaceae family for the first time.
[Mh] Termos MeSH primário: Gentianella/química
Lignanas/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Etanol/química
Glucosídeos/química
Glucosídeos/isolamento & purificação
Lignanas/isolamento & purificação
Espectroscopia de Ressonância Magnética
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Glucosides); 0 (Lignans); 0 (pinoresinol 4-O-glucopyranoside); 3K9958V90M (Ethanol); 86680-32-2 (citrusinine I)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:141022
[Lr] Data última revisão:
141022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141023
[St] Status:MEDLINE


  8 / 21 MEDLINE  
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[PMID]:25204153
[Au] Autor:Wu JR; Wu LH; Zhao ZL; Wang ZT
[Ti] Título:[Simultaneous determination of five iridoids in gentianae macrophyllae radix and their local variety by HPLC].
[So] Source:Zhongguo Zhong Yao Za Zhi;39(4):715-20, 2014 Feb.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:This study aims to establish a new method for quality evaluation of Gentianae Macrophyllae Radix by simultaneous determination of five iridoids (loganic acid, 6'-O-beta-D-glucopyranosylgentiopicroside, swertiamarin, gentiopicroside, sweroside), and to detect five iridoids in the root of eight species (Gentiana macrophylla, G. straminea, G. crassicaulis, G. dahurica, G. robusta, G. waltonii, G. lhassica, and G. tibetica). The separation was carried out on a Shiseido SPOLAR C18 (4.6 mm x 250 mm, 5 microm) column eluted with mobile phase of water containing 0.04% formic acid (A) and acetonitrile (B) in a gradient program. The flow rate was 0.8 mL x min(-1). The detect wavelength was set at 240 nm. The column temperature was kept at 30 degrees C. The volume of injection was 5 microL. The five iridoids were well separated with ideal linear correlations. The average recoveries were 97.35% - 106.23%. All the five iridoids were detected in the root of eight species. The contents of same species changed in a somewhat wider range. The contents in root of G. dahurica were lower than that in other species.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/análise
Gentianella/química
Glicosídeos Iridoides/análise
[Mh] Termos MeSH secundário: China
[Pt] Tipo de publicação:ENGLISH ABSTRACT; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Iridoid Glycosides)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140910
[Lr] Data última revisão:
140910
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140911
[St] Status:MEDLINE


  9 / 21 MEDLINE  
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[PMID]:24806310
[Au] Autor:Huang YJ; Lu H; Yu XL; Zhang SW; Wang WQ; Fen LY; Xuan LJ
[Ad] Endereço:State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
[Ti] Título:Dammarane-type triterpenoids from Gentianella azurea.
[So] Source:J Nat Prod;77(5):1201-9, 2014 May 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thirteen new dammarane-type triterpenoids (1-13) and four known analogues, gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17), were isolated from Gentianella azurea. Their structures were elucidated by detailed analysis of the NMR, MS, and X-ray crystallographic data. This is the first report of dammarane-type triterpenoids in the Gentianella genus. In addition, the known structures of gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17) were revised based on the X-ray diffraction analysis. Gentirigeoside A (15) was found to inhibit nitric oxide production in RAW 264.7 macrophages with an IC50 value of 6.6 ± 2.1 µM.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Gentianella/química
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Camundongos
Estrutura Molecular
Óxido Nítrico/biossíntese
Ressonância Magnética Nuclear Biomolecular
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Lipopolysaccharides); 0 (Triterpenes); 31C4KY9ESH (Nitric Oxide); 545-22-2 (dammarane)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140911
[Lr] Data última revisão:
140911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140509
[St] Status:MEDLINE
[do] DOI:10.1021/np500077z


  10 / 21 MEDLINE  
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[PMID]:22486039
[Au] Autor:Lima B; Sánchez M; Luna L; Agüero MB; Zacchino S; Filippa E; Palermo JA; Tapia A; Feresin GE
[Ad] Endereço:Instituto de Biotecnología - Instituto de Ciencias Básicas, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 oeste, CP 5400, San Juan, Argentina.
[Ti] Título:Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean Slopes of San Juan Province, Argentina.
[So] Source:Z Naturforsch C;67(1-2):29-38, 2012 Jan-Feb.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The infusion of the aerial parts of Gentianella multicaulis (Gillies ex Griseb.) Fabris (Gentianaceae), locally known as 'nencia', is used in San Juan Province, Argentina, as stomachic and as a bitter tonic against digestive and liver problems. The bioassay-guided isolation of G. multicaulis extracts and structural elucidation of the main compounds responsible for the antifungal and free radical scavenging activities were performed. The extracts had strong free radical scavenging effects in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (45-93% at 10 microg/mL) and ferric-reducing antioxidant power (FRAP) assay at 200 microg/mL. Demethylbellidifolin (4) had high antioxidant activity in the DPPH and FRAP assay. The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes, and T. rubrum were moderately inhibited by the different extracts (MIC values of 125-250 microg/mL). Demethylbellidifolin (4), bellidifolin (5), and isobellidifolin (6) showed an antifungal effect (MIC values of 50 microg/mL), while swerchirin (3) was less active with a MIC value of 100 microg/mL. In addition, oleanolic acid (1) and ursolic acid (2) were also isolated. These findings demonstrate that Gentianella multicaulis collected in the mountains of the Province of San Juan, Argentina, is an important source of compounds with antifungal and antioxidant activities.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Gentianella/química
[Mh] Termos MeSH secundário: Argentina
Cromatografia Líquida de Alta Pressão
Depuradores de Radicais Livres/farmacologia
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Free Radical Scavengers)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:120410
[Lr] Data última revisão:
120410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120411
[St] Status:MEDLINE



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