Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.456.750.594 [Categoria DeCS]
Referências encontradas : 166 [refinar]
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[PMID]:28779689
[Au] Autor:Dutta Gupta S; Karmakar A
[Ad] Endereço:Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. Electronic address: sdg@agfe.iitkgp.ernet.in.
[Ti] Título:Machine vision based evaluation of impact of light emitting diodes (LEDs) on shoot regeneration and the effect of spectral quality on phenolic content and antioxidant capacity in Swertia chirata.
[So] Source:J Photochem Photobiol B;174:162-172, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present study demonstrates the influence of LED irradiance of various wavelengths on shoot regeneration, biomass accumulation, photosynthetic pigment contents, and antioxidant potentials of Swertia chirata - a critically endangered medicinal plant. Mixed treatment of blue (BL) and red LEDs (RL) in equal proportion (1:1) significantly improved the shoot regeneration response. A machine vision system was developed to assess the shoot regeneration potential under different lighting treatments. Regenerated shoots exposed under BL:RL (1:1) exhibited higher biomass accumulation and canopy development compared to other lighting treatments. Improved canopy growth was evident from the increase in the area, major axis, minor axis, convex area, equivalent diameter and perimeter of regenerated shoot clusters. A higher correlation of dry weight (DW) was noted with the image feature, weighted density (WD) than the fresh weight (FW) in all the LED treated cultures. The significant correlation between DW and WD implies that the image feature WD can be adopted as a non-invasive approach for measuring biomass accumulation as well as detecting hyperhydricity. The developed machine vision approach provides a new direction in the evaluation of shoot organogenesis that displayed features including both shoot multiplication and canopy development. Chlorophyll and carotenoid contents of the regenerated shoots were found to be higher under BL:RL (1:1) than the other treatments. Supplementation of RL led to a reduction in the pigment contents. Spectral quality of lights also significantly influenced the accumulation of total phenolics, flavonoids and flavonols. Cultures exposed under BL exhibited the maximum accumulation of polyphenols. A similar effect of spectral quality was observed with the antioxidant capacity and reducing power potential of leaf extract. The findings demonstrate the ability of LEDs in inducing shoot regeneration as well as accumulation of phenolic antioxidants and suggest that the proportion of blue and red LEDs is an important factor in achieving the optimum response.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Luz
Fenóis/metabolismo
Brotos de Planta/fisiologia
Brotos de Planta/efeitos da radiação
Regeneração/efeitos da radiação
Swertia/efeitos da radiação
[Mh] Termos MeSH secundário: Flavonóis/metabolismo
Imagem Molecular
Fotossíntese/efeitos da radiação
Swertia/metabolismo
Swertia/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonols); 0 (Phenols)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE


  2 / 166 MEDLINE  
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[PMID]:28490237
[Au] Autor:Li J; Zhao YL; Huang HY; Wang YZ
[Ad] Endereço:* Institute of Medicine Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, P. R. China.
[Ti] Título:Phytochemistry and Pharmacological Activities of the Genus Swertia (Gentianaceae): A Review.
[So] Source:Am J Chin Med;45(4):667-736, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Swertia plants have been considered to be medicinal plants useful for the treatment of various ailments for thousands of years, especially in Asian countries. This is due to the broad variety of chemical compounds that provide multiple ligands for bonding to different endogenous biomacromolecules for patients. Chemical constituents and pharmacological activities of Swertia plants are summarized in this paper. Approximately 419 metabolites and 40 bioactive compounds have been reported from 30 Swertia species, including xanthones, flavonoids, seco-iridiods, iridiods, triterpenoids, alkaloids, volatiles, and other secondary metabolites. The bioactivities of Swertia plants include anticarcinogenic, hepatoprotective, anti-oxidant, hypoglycemic, anthelmintic, antibacterial, antifungal, anti-diabetic, gut, and airways modulatory, metabolizing isozymes inhibitory, neuroprotective, HIV-I reverse transcriptases inhibitory, anticholinergic, and CNS-depressant activities, etc. In addition, biosynthetic pathways of xanthones, and seco-iridiods, two most important secondary metabolites for Swertia, are elucidated. The xanthones biosynthetic pathway is a mixed biosynthetic pathway involved the shikimate and the malonate routes, and the seco-iridoid pathway starts with geraniol derived from IPP which is produced either via the MEP or the MVA pathway. This review will offer a reference for future researches on the protection of natural resources, the investigation of therapeutic basis, new drug development, and so forth. Metabolic pathways of some crucial active compounds were also discussed in this review.
[Mh] Termos MeSH primário: Extratos Vegetais/química
Extratos Vegetais/farmacologia
Swertia/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Animais
Anti-Helmínticos
Antibacterianos
Antifúngicos
Antineoplásicos Fitogênicos
Antioxidantes
Depressores do Sistema Nervoso Central
Antagonistas Colinérgicos
Flavonoides/biossíntese
Flavonoides/isolamento & purificação
Seres Humanos
Hipoglicemiantes
Iridoides/isolamento & purificação
Fármacos Neuroprotetores
Inibidores da Transcriptase Reversa
Triterpenos/isolamento & purificação
Xantonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anthelmintics); 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Central Nervous System Depressants); 0 (Cholinergic Antagonists); 0 (Flavonoids); 0 (Hypoglycemic Agents); 0 (Iridoids); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Reverse Transcriptase Inhibitors); 0 (Triterpenes); 0 (Xanthones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500380


  3 / 166 MEDLINE  
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[PMID]:28278647
[Au] Autor:Wang H; Yuan X; Huang H; Zhang B; Cao C; Zhao HP
[Ad] Endereço:a Institute of Chemical Engineering , Qinghai University , Xining , China.
[Ti] Título:Chemical constituents from Swertia mussotii Franch. (Gentianaceae).
[So] Source:Nat Prod Res;31(14):1704-1708, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chemical investigation of ethanolic extract from Swertia mussotii Franch. has resulted in the isolation of 11 compounds which were identified as Orcinol-ß-D-glucoside (1), Shamimin (2), Mangiferin (3), Decussatin (4), Bellidifolin (5), Desmethylbellidifolin (6), Protocatechuic acid (7), 1,7-Dihydroxy-3,8-dimethoxyxanthone (8), 1,8-Dihydroxy-3,5-dimethoxyxanthone (9), 1-Hydroxy-3,5-dimethoxyxanthone (10), Telephioidin (11). The chemical structures of these compounds were identified by a combination of spectroscopic analysis and a comparison with those reported in literature. Among them, compounds 1, 2, 7 and 11 were isolated from the genus Swertia for the first time. Moreover, the chemotaxonomic significance of these compounds was summarised. The chemotaxonomic study suggests that there is a close chemotaxonomic relationship between S. mussotii and other species of Swertia, such as S. punicea, S. macrosperma, S. japonica, S. phragmitiphylla, S. chirayita, S. cordata and S. binchuanensis, with presence of compounds 3~6, 8~10. The xanthones and their glycosides may sever as important chemotaxonomic markers of Swertia genus.
[Mh] Termos MeSH primário: Swertia/química
[Mh] Termos MeSH secundário: Classificação/métodos
Gentianaceae/química
Glicosídeos/análise
Glicosídeos/isolamento & purificação
Xantonas/análise
Xantonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Xanthones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1286480


  4 / 166 MEDLINE  
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[PMID]:28030961
[Au] Autor:Wu HY; Sheng Y; Kan XQ; Mou LY; Hu QF; Li GP
[Ad] Endereço:a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650500 , China.
[Ti] Título:Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity.
[So] Source:J Asian Nat Prod Res;19(8):774-779, 2017 Aug.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively.
[Mh] Termos MeSH primário: Inibidores de 5-alfa Redutase/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Swertia/química
Xantonas/isolamento & purificação
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Inibidores de 5-alfa Redutase/química
Inibidores de 5-alfa Redutase/farmacologia
Medicamentos de Ervas Chinesas/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Xantonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5-alpha Reductase Inhibitors); 0 (Drugs, Chinese Herbal); 0 (Xanthones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1264392


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[PMID]:27917657
[Au] Autor:Wu HY; Kan XQ; Sheng Y; Mou LY; Yang QS; Hu QF; Li GP
[Ad] Endereço:a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , P.R. China.
[Ti] Título:Two new phenylpropanoids from Swertia atroviolacea and their anti-5α-reductase activity.
[So] Source:Nat Prod Res;31(12):1431-1436, 2017 Jun.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new phenylpropanoids (1-2), together with two known lignans (3-4), were isolated from whole herb of Swertia atroviolacea. The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1 and 2 were evaluated for their anti-5α-reductase activity. The results revealed that 1 and 2 showed weak activity with reductase inhibitions of 45.6 ± 2.8% and 38.4 ± 2.5%, respectively.
[Mh] Termos MeSH primário: Inibidores de 5-alfa Redutase/isolamento & purificação
Fenilpropionatos/isolamento & purificação
Swertia/química
[Mh] Termos MeSH secundário: Inibidores de 5-alfa Redutase/farmacologia
Lignanas/isolamento & purificação
Fenilpropionatos/química
Fenilpropionatos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5-alpha Reductase Inhibitors); 0 (Lignans); 0 (Phenylpropionates); 0 (atroviolacin A); 0 (atroviolacin B)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1261340


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[PMID]:27866977
[Au] Autor:Wu X; Gu Y; Li L
[Ad] Endereço:Department of Cardiology, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Título:The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats.
[So] Source:Toxicol Lett;265:9-16, 2017 Jan 04.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Qing Ye Dan (QYD) is the whole plant of Swertia mileensis and used in Chinese folk medicine for the treatment of prostatitis, benign prostatic hyperplasia (BPH) and so on. This study was to investigate the effects of QYD and its main component swertiamarin on BPH induced by testosterone in rats. The prostatic expressions of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), basic fibroblast growth factor (ßFGF) and proliferating cell nuclear antigen (PCNA) were detected by immunohistochemistry assay. Prostatic levels of oxidative stress and inflammatory-related factors were also analyzed. Additionally, the prostatic expressions of androgen receptor (AR), estrogen receptor (ER)-α, ER-ß, hypoxia-inducible factor (HIF)-1α, B-cell CLL/lymphoma (Bcl)-2 and Bcl-2-associated X protein (Bax) were measured by western blot. The epithelial-mesenchymal transition (EMT) associated factors were evaluated by quantitative RT-PCR. It showed that QYD and swertiamarin ameliorated the testosterone-induced prostatic hyperplasia and collagen deposition, attenuated the over-expressions of HIF-1α, VEGF, EGF, ßFGF, PCNA, AR and ER-α, reduced the ratio of Bcl-2/Bax, enhanced the expression of ER-ß, inhibited the oxidative stress and local inflammation, as well as relieved prostatic EMT. It suggested that QYD and swertiamarin had prostatic protective potential against BPH.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Transição Epitelial-Mesenquimal/efeitos dos fármacos
Glucosídeos Iridoides/uso terapêutico
Hiperplasia Prostática/prevenção & controle
Pironas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/toxicidade
Antioxidantes/administração & dosagem
Antioxidantes/isolamento & purificação
Antioxidantes/toxicidade
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/toxicidade
Transição Epitelial-Mesenquimal/imunologia
Feminino
Glucosídeos Iridoides/administração & dosagem
Glucosídeos Iridoides/isolamento & purificação
Glucosídeos Iridoides/toxicidade
Masculino
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/imunologia
Próstata/efeitos dos fármacos
Próstata/imunologia
Próstata/metabolismo
Próstata/patologia
Hiperplasia Prostática/induzido quimicamente
Hiperplasia Prostática/metabolismo
Hiperplasia Prostática/patologia
Pironas/administração & dosagem
Pironas/isolamento & purificação
Pironas/toxicidade
Ratos Wistar
Swertia/química
Testosterona/administração & dosagem
Testosterona/farmacologia
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Drugs, Chinese Herbal); 0 (Iridoid Glucosides); 0 (Pyrones); 0 (Qing Ye Dan); 3XMK78S47O (Testosterone); 4038595T7Y (swertiamarin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE


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[PMID]:27687566
[Au] Autor:Jia Y; Xiong C
[Ad] Endereço:a Department of Pharmacy , PLA General Hospital , Beijing , P.R. China.
[Ti] Título:Assessing the biological activities of xanthone derivatives from Swertia macrosperma C.B. Clark.
[So] Source:Nat Prod Res;31(6):704-706, 2017 Mar.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The anti-microbial and anti-oxidant effects of xanthones extract from Swertia macrosperma C.B. Clark were investigated using extracts from whole plant and partitioned by petroleum ether, ethyl acetate and n-butanol, respectively. Anti-microbial and anti-oxidant activities were detected among different fractions. High-performance liquid chromatography was performed to separate and purify the elutions. The compounds were elucidated by 1H, 13C NMR and LCMS. The ethyl acetate extract showed maximum inhibitory activity in fungal organisms and Gram-positive bacteria, and had the highest anti-oxidant capacity. Eight xanthones were isolated in ethyl acetate fraction from S. macrosperma. Moreover, compounds IV-VI and VIII were isolated from the plant for the first time, and compound VII had the strongest anti-oxidant effect.
[Mh] Termos MeSH primário: Extratos Vegetais/farmacologia
Swertia/química
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/farmacologia
Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Antifúngicos/química
Antifúngicos/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Cromatografia Líquida de Alta Pressão
Fungos/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Extratos Vegetais/química
Coelhos
Solventes
Xantonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Antifungal Agents); 0 (Antioxidants); 0 (Plant Extracts); 0 (Solvents); 0 (Xanthones)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1214827


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[PMID]:27618937
[Au] Autor:Mishra D; Joshi S; Mishra S; Sah ML; Ajay S; Shaw AK
[Ad] Endereço:a Department of Applied Chemistry , Birla Institute of Applied Sciences , Bhimtal, Nainital , Uttarakhand , India.
[Ti] Título:New Xanthone from the roots of Swertia cordata (G. Don) Clarke.
[So] Source:Nat Prod Res;31(2):155-158, 2017 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chloroform extract of Swertia cordata (G. Don) roots was subjected to column chromatography, afforded two (one new and one known) xanthones. Both the compounds were isolated for the first time from S. cordata. The structures of the isolated compounds were established on the basis of melting point,1D ( H NMR & C NMR) and 2D ( H H COSY, HSQC & HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry.
[Mh] Termos MeSH primário: Extratos Vegetais/química
Swertia/química
Xantonas/química
[Mh] Termos MeSH secundário: Índia
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Xanthones)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE


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[PMID]:27738917
[Au] Autor:Lad H; Bhatnagar D
[Ad] Endereço:School of Biochemistry, Devi Ahilya University, Khandwa Road, Indore, MP, 452001, India.
[Ti] Título:Amelioration of oxidative and inflammatory changes by Swertia chirayita leaves in experimental arthritis.
[So] Source:Inflammopharmacology;24(6):363-375, 2016 Dec.
[Is] ISSN:1568-5608
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present study was aimed to determine the therapeutic effects of Swertia chirayita leaves against oxidative and inflammatory injuries in Freund's complete adjuvant (FCA) induced arthritic rats. The extract was evaluated for its phytoconstituents and various invitro antioxidant properties followed by its in vivo effects. The hydroethanolic extract of S. chirayita leaves (SCE) was orally administered (200 mg/kg body weight, per day, p.o.) and the effect on the liver lipid peroxidation (LPO), antioxidant status, protein carbonyl formation along with the histopathology of liver were evaluated after induction of adjuvant arthritis. The markers of inflammation and arthritis, such as tumor necrosis factor-α (TNF-α), interleukin 1α (IL-1α), inhibition of paw edema, along with the histological and radiographic changes in the arthritic ankle joint were studied with and without SCE administration. The result showed the presence of major phytoconstituents, such as phenolic, flavonoid and terpenoid content in SCE. HPLC analysis revealed the presence of swertiamarin and amarogentin in high concentration. The extract also showed in vitro antioxidant potential which has positive correlation with the phytoconstituents. The result of in vivo study showed elevated malondialdehyde (MDA) and carbonyl content indicative of LPO and protein oxidation, respectively, with compromised intracellular antioxidant defense system in arthritic rats, which were significantly normalized after SCE treatment. The increase in serum proinflammatory cytokines (TNF- α and IL-1α) and paw edema of arthritic rats was significantly suppressed by SCE. Histology and radiographic analysis of arthritic ankle joints indicated abnormal changes. Marked reduction in inflammation and arthritic changes were observed after treatment with SCE. The present investigation suggests that hydroethanolic extract of S. chirayita leaves exhibit potential immunomodulatory effects, which may possibly be due to boosting the intracellular antioxidant defense.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Artrite Experimental/tratamento farmacológico
Citocinas/sangue
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Swertia/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Antioxidantes/metabolismo
Artrite Experimental/imunologia
Artrite Experimental/metabolismo
Edema/tratamento farmacológico
Edema/imunologia
Interleucina-1alfa/sangue
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Extratos Vegetais/administração & dosagem
Folhas de Planta/química
Ratos Wistar
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cytokines); 0 (Interleukin-1alpha); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE


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[PMID]:27517885
[Au] Autor:Xiang B; Li X; Qian J; Wang L; Ma L; Tian X; Wang Y
[Ad] Endereço:School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Anshan Road 312, Tianjin 300193, China. xiangbeibei03230@163.com.
[Ti] Título:The Complete Chloroplast Genome Sequence of the Medicinal Plant Swertia mussotii Using the PacBio RS II Platform.
[So] Source:Molecules;21(8), 2016 Aug 09.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Swertia mussotii is an important medicinal plant that has great economic and medicinal value and is found on the Qinghai Tibetan Plateau. The complete chloroplast (cp) genome of S. mussotii is 153,431 bp in size, with a pair of inverted repeat (IR) regions of 25,761 bp each that separate an large single-copy (LSC) region of 83,567 bp and an a small single-copy (SSC) region of 18,342 bp. The S. mussotii cp genome encodes 84 protein-coding genes, 37 transfer RNA (tRNA) genes, and eight ribosomal RNA (rRNA) genes. The identity, number, and GC content of S. mussotii cp genes were similar to those in the genomes of other Gentianales species. Via analysis of the repeat structure, 11 forward repeats, eight palindromic repeats, and one reverse repeat were detected in the S. mussotii cp genome. There are 45 SSRs in the S. mussotii cp genome, the majority of which are mononucleotides found in all other Gentianales species. An entire cp genome comparison study of S. mussotii and two other species in Gentianaceae was conducted. The complete cp genome sequence provides intragenic information for the cp genetic engineering of this medicinal plant.
[Mh] Termos MeSH primário: Proteínas de Cloroplastos/genética
Genoma de Cloroplastos
Plantas Medicinais/genética
RNA de Plantas/genética
Swertia/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chloroplast Proteins); 0 (RNA, Plant)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE



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