Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.456.875 [Categoria DeCS]
Referências encontradas : 27 [refinar]
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  1 / 27 MEDLINE  
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[PMID]:29244856
[Au] Autor:Araújo SA; Soares AMDS; Silva CR; Almeida Júnior EB; Rocha CQ; Ferreira ATDS; Perales J; Costa-Júnior LM
[Ad] Endereço:Laboratory of Plant Biochemistry, Chemical Engineering Course, Centre for Exact Sciences and Technology, Federal University of Maranhão, São Luíz MA, Brazil.
[Ti] Título:In vitro anthelmintic effects of Spigelia anthelmia protein fractions against Haemonchus contortus.
[So] Source:PLoS One;12(12):e0189803, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gastrointestinal nematodes are a significant concern for animal health and well-being, and anthelmintic treatment is mainly performed through the use of chemical products. However, bioactive compounds produced by plants have shown promise for development as novel anthelmintics. The aim of this study is to assess the anthelmintic activity of protein fractions from Spigelia anthelmia on the gastrointestinal nematode Haemonchus contortus. Plant parts were separated into leaves, stems and roots, washed with distilled water, freeze-dried and ground into a fine powder. Protein extraction was performed with sodium phosphate buffer (75 mM, pH 7.0). The extract was fractionated using ammonium sulfate (0-90%) and extensively dialyzed. The resulting fractions were named LPF (leaf protein fraction), SPF (stem protein fraction) and RPF (root protein fraction), and the protein contents and activities of the fractions were analyzed. H. contortus egg hatching (EHA), larval exsheathment inhibition (LEIA) and larval migration inhibition (LMIA) assays were performed. Proteomic analysis was conducted, and high-performance liquid chromatography (HPLC) chromatographic profiles of the fractions were established to identify proteins and possible secondary metabolites. S. anthelmia fractions inhibited H. contortus egg hatching, with LPF having the most potent effects (EC50 0.17 mg mL-1). During LEIA, SPF presented greater efficiency than the other fractions (EC50 0.25 mg mL-1). According to LMIA, the fractions from roots, stems and leaves also reduced the number of larvae, with EC50 values of 0.11, 0.14 and 0.21 mg mL-1, respectively. Protein analysis indicated the presence of plant defense proteins in the S. anthelmia fractions, including protease, protease inhibitor, chitinase and others. Conversely, secondary metabolites were absent in the S. anthemia fractions. These results suggest that S. anthelmia proteins are promising for the control of the gastrointestinal nematode H. contortus.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Hemoncose/tratamento farmacológico
Haemonchus/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/química
Cromatografia Líquida de Alta Pressão
Hemoncose/parasitologia
Hemoncose/veterinária
Haemonchus/patogenicidade
Larva/efeitos dos fármacos
Larva/patogenicidade
Loganiaceae/química
Extratos Vegetais/química
Folhas de Planta/química
Proteínas de Plantas/administração & dosagem
Proteínas de Plantas/química
Proteômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Plant Extracts); 0 (Plant Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189803


  2 / 27 MEDLINE  
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[PMID]:26625339
[Au] Autor:Lin A; Su X; She D; Qiu K; He Q; Liu Y
[Ad] Endereço:Guangdong Provincial Hospital of Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou 510120, China.
[Ti] Título:LC-MS/MS determination and comparative pharmacokinetics of strychnine, brucine and their metabolites in rat plasma after intragastric administration of each monomer and the total alkaloids from Semen Strychni.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1008:65-73, 2016 Jan 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A rapid, specific and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the simultaneous determination of strychnine, brucine, strychnine N-oxide and brucine N-oxide in rat plasma. Plasma samples were pretreated via simple protein precipitation with methanol and ephedrine hydrochloride was used as internal standard. Chromatographic separation was carried out on an ZORBAX Eclipse XDB-C18 column (2.1×150mm, 3.5µm) by gradient elution with methanol and 10mM ammonium acetate (adjusted to pH 4.0 with formic acid). The quantification of the analytes was performed by mass spectrometry with TurboIonSpray ionization (ESI) inlet in the positive ion multiple reaction monitoring (MRM) mode. The results showed that the calibration curve was linear in the concentration range of 0.510∼306.3ngmL(-1) for strychnine, brucine and 0.102∼306.0ngmL(-1) for strychnine N-oxide and brucine N-oxide, respectively. The intra- and inter-day precisions were less than 14.9%, and the accuracy ranged from 89.4 to 113% at three QC levels for the 4 analytes. The validated method was successfully applied to the pharmacokinetic study of strychnine, brucine, strychnine N-oxide and brucine N-oxide in rat plasma after oral administration of each monomer and the total alkaloids from Semen Strychni. After single oral administration of the total alkaloids from Semen Strychni at 4 dose levels, Cmax, AUC0-t of strychnine and brucine increased and were proportional to the oral doses. In comparative pharmacokinetics studies, no significant difference was found between each monomer and the total strychnos alkaloids on the pharmacokinetic parameters such as Cmax and AUC. Mean Cmax and AUC of strychnine and brucine were slight increased in the monomer groups in comparison to the total strychnos alkaloids groups, which suggested that some other alkaloids in the Semen Strychni may decrease the absorption of strychnine and brucine in body.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Loganiaceae/química
Estricnina/análogos & derivados
Estricnina/farmacocinética
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Ratos
Estricnina/administração & dosagem
Estricnina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
6NG17YCK6H (brucine); H9Y79VD43J (Strychnine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151202
[St] Status:MEDLINE


  3 / 27 MEDLINE  
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[PMID]:26345277
[Au] Autor:Forrester GS; Rawlings B; Davila-Ross M
[Ad] Endereço:Department of Psychology, Faculty of Science and Technology, University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK.
[Ti] Título:An analysis of bimanual actions in natural feeding of semi-wild chimpanzees.
[So] Source:Am J Phys Anthropol;159(1):85-92, 2016 Jan.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of the current study was to investigate the lateral dominance for a bimanually coordinated natural feeding behavior in semi-wild chimpanzees. METHODS: Strychnos spp. fruit consumption behaviors in semi-wild chimpanzees as an ecologically comparable feeding behavior to those found in cerebral lateralization studies of non-primate species was investigated. Video recordings of 33 chimpanzees were assessed while they consumed hard-shelled strychnos fruits. Statistical and descriptive measures of hand dominance to highlight lateralized patterns were explored. RESULTS: Statistical evaluation of feeding bouts revealed a group-level right-handed bias for bimanual coordinated feeding actions, however, few individuals were statistically lateralized. Descriptive analyses revealed that the majority of individuals were lateralized and possessed a right-handed bias for strychnos feeding behavior. CONCLUSIONS: The results provided empirical evidence in support of an early evolutionary delineation of function for the right and left hemispheres. The present findings suggest that great apes express an intermediate stage along the phylogenetic trajectory of human manual lateralization.
[Mh] Termos MeSH primário: Comportamento Alimentar/fisiologia
Lateralidade Funcional/fisiologia
Pan troglodytes/fisiologia
[Mh] Termos MeSH secundário: Animais
Antropologia Física
Feminino
Frutas
Loganiaceae
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150909
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.22845


  4 / 27 MEDLINE  
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[PMID]:26386382
[Au] Autor:Li Y; Wang J; Xiao Y; Wang Y; Chen S; Yang Y; Lu A; Zhang S
[Ad] Endereço:Key laboratory of Industrial Ecology and Environmental Engineering (MOE), Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, Liaoning 116024, PR China. Electronic address: yanli@dlut.edu.cn.
[Ti] Título:A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis.
[So] Source:J Ethnopharmacol;175:301-14, 2015 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGY RELEVANCE: The angiogenesis control at the initiation of rheumatoid arthritis (RA) that mainly blocks the inflammatory cascades expects to attenuate the action of angiogenic mediators, synovial angiogenesis, and to partially reverse the erosive bone damage. Two typical Chinese herbs, Semen Strychni and Tripterygium wilfordii Hook F (TwHF) have been used as a remedy to treat RA since ancient time. However, their functioning mechanisms are still unknown. Thus it is necessary to exploit their underlying mechanism for the treatment of RA. METHODS: This study was undertaken to analyze their underlying mechanism based on a systems biology platform. Firstly, active components of the two herbs were screened out from TcmSP database based on their OB and DL values. Then their potential targets were predicted by using Random Forest, Support Vector Machine, and validated via docking process. Finally, a network of compound-target was constructed. RESULTS: In this work, 27 and 33 active compounds were screened out from Semen Strychni and TwHF, targeting 28 and 32 potential proteins, respectively. The results show that the two herbs modulate the angiogenesis mediators through both direct and indirect pathways, and 21 common targets shared by Semen Strychni and TwHF bear major responsibility for treating RA. CONCLUSIONS: The underlying mechanism of Semen Strychni and TwHF in treatment of RA is through multiple targets interaction by their blocking of the angiogenesis mediator cascades. This may provide us a better understanding of the function of the two herbs for the treatment of RA, as well as a clue to unveil their possible treatment effects of other systemic diseases, and in this way, hopefully the screening models may facilitate the discovery of novel combined drugs.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Artrite Reumatoide/tratamento farmacológico
Loganiaceae
Extratos Vegetais/farmacologia
Tripterygium
[Mh] Termos MeSH secundário: Administração Oral
Inibidores da Angiogênese/farmacocinética
Inibidores da Angiogênese/uso terapêutico
Disponibilidade Biológica
Descoberta de Drogas/métodos
Farmacologia/métodos
Fitoterapia
Extratos Vegetais/farmacocinética
Extratos Vegetais/uso terapêutico
Raízes de Plantas
Sementes
Biologia de Sistemas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Plant Extracts)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150920
[St] Status:MEDLINE


  5 / 27 MEDLINE  
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[PMID]:25428165
[Au] Autor:Isa AI; Awouafack MD; Dzoyem JP; Aliyu M; Magaji RA; Ayo JO; Eloff JN
[Ti] Título:Some Strychnos spinosa (Loganiaceae) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities.
[So] Source:BMC Complement Altern Med;14:456, 2014 Nov 27.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Strychnos spinosa Lam. is a deciduous tree used in traditional medicine to treat infectious diseases. This study is designed to determine the antimicrobial, antioxidant and cytotoxic activities of extracts and fractions from leaves of S. spinosa. METHODS: Extracts were obtained by maceration with acetone, methanol and dichloromethane/methanol (1/1) while fractions were prepared by liquid-liquid fractionation of the acetone extract. A broth serial microdilution method with tetrazolium violet as growth indicator was used to determine the minimum inhibitory concentration (MIC) against fungi, Gram-positive and Gram-negative bacteria. The antioxidant activity was determined using free-radical-scavenging assays, and the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide reduction assay was used to determine cytotoxicity. RESULTS: Four extracts and five fractions had good to weak antimicrobial activity with MICs ranging from 0.04 to >1.25 mg/ml against both fungi and bacteria. The chloroform and ethyl acetate fractions had an MIC of 0.08 mg/ml against Aspergillus fumigatus. The n-butanol fraction had an MIC of 0.04 mg/ml against Cryptococcus neoformans. The hexane and chloroform fractions had an MIC of 0.08 mg/ml against Staphylococcus aureus. The antioxidant activities were much lower than that of the positive controls. Except for the alkaloid extract, all the extracts and fractions had free-radical-scavenging activity (IC50 ranging from 33.66 to 314.30 µg/ml). The cytotoxicity on Vero cells was reasonable to low with LC50 values ranging between 30.56 and 689.39 µg/ml. CONCLUSION: The acetone extract and the chloroform fraction had the highest antibacterial activity. By solvent-solvent fractionation it was possible to increase the activity against A. fumigatus and to decrease the cytotoxicity leading to a potentially useful product to protect animals against aspergillosis. Our results therefore support the use of S. spinosa leaves in traditional medicine to treat infectious diseases.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Aspergillus fumigatus/efeitos dos fármacos
Cryptococcus neoformans/efeitos dos fármacos
Extratos Vegetais/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Strychnos
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Cercopithecus aethiops
Bactérias Gram-Negativas/efeitos dos fármacos
Loganiaceae
Medicina Tradicional
Testes de Sensibilidade Microbiana
Extratos Vegetais/efeitos adversos
Folhas de Planta
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Antifungal Agents); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141128
[St] Status:MEDLINE
[do] DOI:10.1186/1472-6882-14-456


  6 / 27 MEDLINE  
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[PMID]:24929247
[Au] Autor:Foster CS; Ho SY; Conn BJ; Henwood MJ
[Ad] Endereço:School of Biological Sciences, University of Sydney, Sydney, NSW 2006, Australia. Electronic address: charles.foster@sydney.edu.au.
[Ti] Título:Molecular systematics and biogeography of Logania R.Br. (Loganiaceae).
[So] Source:Mol Phylogenet Evol;78:324-33, 2014 Sep.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The angiosperm genus Logania R.Br. (Loganiaceae) is endemic to the mainland of Australia. A recent genetic study challenged the monophyly of Logania, suggesting that its two sections, Logania sect. Logania and Logania sect. Stomandra, do not group together. Additionally, the genus has a disjunct distribution, with a gap at the Nullarbor Plain in southern Australia. Therefore, Logania is a favourable candidate to gain insight into phylogenetic relationships and how these might intersect with Earth-history events. Our phylogenetic analyses of DNA sequences of two chloroplast markers (petD and rps16) showed that Logania sect. Logania and L. sect. Stomandra were each resolved as monophyletic, but the genus (as currently circumscribed) was not. Based on our Bayesian estimates of divergence times, the disjunct distributions within Logania sect. Stomandra could have been caused by flooding of the Eucla Basin. However, this biogeographical process cannot account for the distribution of Logania sect. Logania, with long-distance dispersal and establishment seeming more likely.
[Mh] Termos MeSH primário: Loganiaceae/classificação
Filogenia
[Mh] Termos MeSH secundário: Austrália
Teorema de Bayes
Loganiaceae/genética
Filogeografia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140922
[Lr] Data última revisão:
140922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140615
[St] Status:MEDLINE


  7 / 27 MEDLINE  
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[PMID]:24012119
[Au] Autor:Feng T; Li XN; Zhang BH; Li Y; Cai XH; Liu YP; Luo XD
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
[Ti] Título:Gardovatine, a novel Strychnos-Strychnos bisindole alkaloid with cytotoxicity from Gardneria oveta.
[So] Source:Bioorg Med Chem Lett;23(20):5563-5, 2013 Oct 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Gardovatine (1), the first Strychnos-Strychnos alkaloid with a C3/C7 cleaved backbone, was isolated from twigs and leaves of Gardneria ovate, together with an analogue divarine (2). The structure was established by extensive spectroscopic methods. Both compounds showed potential cytotoxicities against five human cancer cell lines.
[Mh] Termos MeSH primário: Alcaloides/química
Alcaloides de Indol/química
Indóis/química
Loganiaceae/química
Strychnos/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Alcaloides/toxicidade
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Alcaloides de Indol/isolamento & purificação
Alcaloides de Indol/toxicidade
Loganiaceae/metabolismo
Espectroscopia de Ressonância Magnética
Conformação Molecular
Folhas de Planta/química
Folhas de Planta/metabolismo
Strychnos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Indole Alkaloids); 0 (Indoles); 0 (divarine); 0 (gardovatine); 8724FJW4M5 (indole)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:130918
[Lr] Data última revisão:
130918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130910
[St] Status:MEDLINE


  8 / 27 MEDLINE  
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[PMID]:23829422
[Au] Autor:Tang HB; Cai HL; Li HD; Zhang LJ; Li XL; Tang JH; Chen ML
[Ad] Endereço:Clinical Pharmacy and Pharmacology Research Institute, Pharmaceutical Department, the Second Xiangya Hospital of Central South University , Changsha , China and.
[Ti] Título:HPLC-DAD method for comprehensive quality control of Semen Strychni.
[So] Source:Pharm Biol;51(11):1378-83, 2013 Nov.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Semen Strychni is the seed of Strychnos nux-vomica L. (Loganiaceae). Its quality control procedure remains an issue since previous reports only focused on Strychnos alkaloids. To the best of our knowledge, chlorogenic acid (a phenolic acid) and loganin (an iridoid glycoside) are selected for the first time as marker constituents of quality control for Semen Strychni because of their bioactive activity correlating with therapeutic effects. OBJECTIVE: This study aimed to develop a simple and comprehensive quantity control method for Semen Strychni. MATERIALS AND METHODS: The optimal ultrasonic extraction procedure was carried out for 45 min using 50% aqueous methanol with 1% formic acid. The satisfactory chromatographic separation was achieved on an Ultimate LP-C18 column with gradient elution using acetonitrile and water containing 30 mmol/L ammonium acetate and 1% formic acid. The high performance liquid chromatography method with diode array detector was validated for linearity, limit of detection and quantification (LOQ), precision, repeatability, accuracy and stability. RESULTS: All the calibration curves showed good linearity (r(2) ≥ 0.999). The LOQ values for chlorogenic acid, loganin, strychnine, brucine, strychnine N-oxide and brucine N-oxide were 0.54, 0.83, 0.48, 0.50, 0.52 and 0.54 µg/mL, respectively. The method was reproducible with good accuracy in the range 95.6-104.4% and relative standard deviation (RSD) values less than 4.55%. The method was then applied to determine the components of the seed coat, seed leaf, endosperm and whole seed of Semen Strychni. CONCLUSION: This newly established method is validated as a simple and practical tool for authentication and quality control of Semen Strychni.
[Mh] Termos MeSH primário: Ácido Clorogênico/análise
Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/análise
Iridoides/análise
Loganiaceae
Espectrofotometria Ultravioleta
[Mh] Termos MeSH secundário: Tampões (Química)
Calibragem
Ácido Clorogênico/normas
Cromatografia Líquida de Alta Pressão/normas
Medicamentos de Ervas Chinesas/normas
Iridoides/normas
Limite de Detecção
Modelos Lineares
Loganiaceae/química
Fitoterapia
Plantas Medicinais
Controle de Qualidade
Padrões de Referência
Reprodutibilidade dos Testes
Sementes
Solventes/química
Espectrofotometria Ultravioleta/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Buffers); 0 (Drugs, Chinese Herbal); 0 (Iridoids); 0 (Solvents); 318ADP12RI (Chlorogenic Acid); H7WJ16Q93C (loganin)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130709
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.792848


  9 / 27 MEDLINE  
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[PMID]:23558539
[Au] Autor:Le Lamer AC; Ibrahim N; Manjary F; Mallet-Ladeira S; Girardi C; Valentin A; Fabre N; Moulis C
[Ad] Endereço:Université de Toulouse, UMR 152 UPS-IRD (Pharmacochimie et Pharmacologie pour le Développement-PHARMA DEV), F-31062 Toulouse Cedex 9, France. anne-cecile.le.lamer@univ-tlse3.fr
[Ti] Título:Macrocyclic spermidine alkaloids from Androya decaryi L. Perrier.
[So] Source:Molecules;18(4):3962-71, 2013 Apr 04.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Three new spermidine alkaloids and two known compounds were isolated from the leaves of Androya decaryi. Their structures were elucidated on the basis of their spectroscopic data (NMR and mass spectrometry), by X-Ray diffraction and by comparison with literature values. Evaluation of the in vitro antiplamosdial properties of the isolated compounds revealed they did not possess any significant activity.
[Mh] Termos MeSH primário: Alcaloides/química
Loganiaceae/química
Extratos Vegetais/química
Espermidina/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Estrutura Molecular
Folhas de Planta/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Plant Extracts); U87FK77H25 (Spermidine)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130406
[St] Status:MEDLINE
[do] DOI:10.3390/molecules18043962


  10 / 27 MEDLINE  
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[PMID]:23422334
[Au] Autor:Olubomehin OO; Abo KA; Ajaiyeoba EO
[Ad] Endereço:Department of Chemical Sciences, Faculty of Science Olabisi Onabanjo University, Ago-Iwoye, Nigeria. yemywumy@yahoo.com
[Ti] Título:Alpha-amylase inhibitory activity of two Anthocleista species and in vivo rat model anti-diabetic activities of Anthocleista djalonensis extracts and fractions.
[So] Source:J Ethnopharmacol;146(3):811-4, 2013 Apr 19.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Anthocleista djalonensis (A. Chev) and Anthocleista vogelii Planch are plants being used in West Africa traditionally to treat various diseases such as malaria, hernia, hypertension, stomach aches, hemorrhoids, syphilis, and diabetes. Diabetes causes about 5% of all deaths globally each year. Chemotherapeutic agents such as biguanides, sulfonylureas, and thiozolidinediones are available for the treatment of diabetes, however, they have undesirable side effects. The need for newer, more effective and less toxic drugs is imperative and the biodiversity of Nigeria has a high potential for drug discovery based on plants used in the ethnomedicine. AIM OF THE STUDY: To investigate the leaves, stem bark and roots of these plants for their probable alpha-amylase inhibitory activities and establish their anti-diabetic activities. The overall goal is do bioassay-guided fractionation and isolation of active anti-diabetic compounds. MATERIALS AND METHODS: Powdered samples (leaves, stem bark and roots) macerated with 80% aqueous methanol were evaluated in vitro using alpha-amylase inhibitory assay while in vivo investigations were carried out on hyperglycemic rats. Diabetes was induced in albino rats by an intraperitoneal injection of alloxan monohydrate (80mg/kg). Plant extracts (1g/kg) were given orally for 7 days, while blood glucose levels were monitored using a one touch glucometer. The crude methanol extracts found to be most active were further partitioned into hexane and ethyl acetate fractions which were also tested in vivo on the diabetic animals. RESULTS: The leaves and stem bark crude methanol extracts of Anthocleista djalonensis gave comparable α-amylase inhibition of 73.66% and 72.90%, respectively which were quite higher than the 38.93% and 22.90% of the same plant parts given by Anthocleista vogelii. The crude stem bark extract of Anthocleista djalonensis exhibited significant peak blood glucose reduction on day 6 (72.59%, p<0.05) which was higher than the leaves or roots which gave 45.73% and 47.46% (p<0.05), respectively The stem bark ethyl acetate fraction of Anthocleista djalonensis gave reduction in blood glucose level of 60.86% (p<0.05). CONCLUSION: From our results, the leaves, stem bark and whole root of both plants exhibited α-amylase inhibitory activities with Anthocleista djalonensis also showing good anti-diabetic activities in vivo indicating that they contain active principles for the management of diabetes. There is justification for the use of the plants traditionally to manage diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Loganiaceae/química
Extratos Vegetais/uso terapêutico
alfa-Amilases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Aloxano/farmacologia
Animais
Glicemia/análise
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/enzimologia
Feminino
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/farmacologia
Loganiaceae/crescimento & desenvolvimento
Masculino
Medicina Tradicional Africana
Nigéria
Casca de Planta/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Folhas de Planta/química
Raízes de Plantas/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 6SW5YHA5NG (Alloxan); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130221
[St] Status:MEDLINE



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