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[PMID]: | 26344425 |
[Au] Autor: | Wu HR; He XF; Jin XJ; Pan H; Shi ZN; Xu DD; Yao XJ; Zhu Y |
[Ad] Endereço: | State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China. |
[Ti] Título: | New nor-ursane type triterpenoids from Gelsemium elegans. |
[So] Source: | Fitoterapia;106:175-83, 2015 Oct. | [Is] ISSN: | 1873-6971 |
[Cp] País de publicação: | Netherlands |
[La] Idioma: | eng |
[Ab] Resumo: | Five new nor-ursane type triterpenoids, gelse-norursane A-E, together with twenty known compounds, were isolated from the whole plant of Gelsemium elegans. The structures of new compounds were established as (2R,3R,7R,17S,19R)-2,3,7,19-tetrahydroxy-6-oxo-24-norurs-4(23),12-dien-28-oic acid (1), (2R,3R,7R,17S)-2,3,7-trihydroxy-6-oxo-24-norurs-4(23), 12-dien-28-oic acid (2), (2R,3R,7R,17S)-2,3,4-trihydroxy-23-norurs-20(30),12-dien-28-oic acid (3), (2R,3R,30R)-2,3-dihydroxy-24-norurs-4(23),12-dien-30-oic acid (4), and (2R,3R,30R)-2, 3-dihydroxy-24-norurs-4,12-dien-30-oic acid (5), using spectroscopic analysis, including HRESIMS, 1D and 2D NMR. The absolute configurations of 1 and 4 were established through comparison of experimental and calculated ECD spectra. The gelse-norursane A-E are isolated as the 24-nor-ursane type triterpenoids from the family Loganiaceae for the first time. The cytotoxicities of the selected compounds against a panel of four human cancer HL60, Hela, Hep-G2, and Smmc 7221 cell lines were evaluated using the MTT assay in vitro. |
[Mh] Termos MeSH primário: |
Gelsemium/química Triterpenos/química
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[Mh] Termos MeSH secundário: |
Linhagem Celular Tumoral Seres Humanos Estrutura Molecular Extratos Vegetais/química Triterpenos/isolamento & purificação
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Plant Extracts); 0 (Triterpenes) |
[Em] Mês de entrada: | 1602 |
[Cu] Atualização por classe: | 151009 |
[Lr] Data última revisão:
| 151009 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 150908 |
[St] Status: | MEDLINE |
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