Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.456.875.500 [Categoria DeCS]
Referências encontradas : 81 [refinar]
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  1 / 81 MEDLINE  
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[PMID]:28705508
[Au] Autor:Liu YC; Lin L; Cheng P; Sun ZL; Wu Y; Liu ZY
[Ad] Endereço:Hunan Engineering Research Center of Veterinary Drug, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China.
[Ti] Título:Fingerprint analysis of Gelsemium elegans by HPLC followed by the targeted identification of chemical constituents using HPLC coupled with quadrupole-time-of-flight mass spectrometry.
[So] Source:Fitoterapia;121:94-105, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Gelsemium elegans, which is a genus of the family Loganiaease, is commonly used as a traditional medicine for promoting animal growth and treating rheumatoid arthritis pain and neuropathic pain, among others. In this study, we first established a valid high-performance liquid chromatography (HPLC) method for the fingerprint analysis of Gelsemium elegans samples. Then, the comprehensive detection of chemical constituents from the samples was performed using HPLC coupled with quadrupole-time-of-flight mass spectrometry. The similarity evaluation results showed that location and area differences influenced the quality of the samples. An efficient strategy for the rapid targeted identification of chemical components was matching with a developed Gelsemium database. As a result, the accurate elemental compositions and known structures of compounds are found as hits. This process facilitated the structural identification of compounds combined with the accurate mass measurement of product ions and fragmentation behaviors. Consequently, 41 components including six alkaloids and non-alkaloids were systematically identified from Gelsemium elegans. The results showed that at least seven relatively major components existing in Gelsemium elegans may be useful for its quality control. The present analytical method combined with the developed Gelsemium database was shown to be a useful tool for investigating the chemical components of Gelsemium products.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Gelsemium/química
Compostos Fitoquímicos/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides/química
Cromatografia Líquida de Alta Pressão
Espectrometria de Massas
Compostos Fitoquímicos/química
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE


  2 / 81 MEDLINE  
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[PMID]:28596027
[Au] Autor:Wang L; Wang JF; Mao X; Jiao L; Wang XJ
[Ad] Endereço:Periodontal Department, Stomatology Hospital of Jilin University, Changchun 130021, China.
[Ti] Título:Gelsedine-type oxindole alkaloids from Gelsemium elegans and the evaluation of their cytotoxic activity.
[So] Source:Fitoterapia;120:131-135, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation on the 70% EtOH extract of the leaves and branches of Gelsemium elegans resulted into the isolation of five new gelsedine-type oxindole alkaloids, gelseleganins A-E (1-5). The structures of the isolated compounds were established based on 1D and 2D ( H- H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potential against seven tumor cell lines. As a result, alkaloids 3 exhibited significant cytotoxic activities against all the tested tumor cell lines with IC values <10µM.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Gelsemium/química
Indóis/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Seres Humanos
Indóis/isolamento & purificação
Estrutura Molecular
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Indoles); 0 (Plant Extracts); 0 (gelsedine); 0S9338U62H (2-oxindole)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


  3 / 81 MEDLINE  
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[PMID]:28300700
[Au] Autor:Zhang W; Zhang SY; Wang GY; Li NP; Chen MF; Gu JH; Zhang DM; Wang L; Ye WC
[Ad] Endereço:Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
[Ti] Título:Five new koumine-type alkaloids from the roots of Gelsemium elegans.
[So] Source:Fitoterapia;118:112-117, 2017 Apr.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viability of three tumor cell lines (A-649, HepG2, and HuH7) were evaluated by the MTT assay.
[Mh] Termos MeSH primário: Gelsemium/química
Alcaloides de Indol/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Dicroísmo Circular
Seres Humanos
Alcaloides de Indol/isolamento & purificação
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indole Alkaloids); 0 (Plant Extracts); 0 (koumine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


  4 / 81 MEDLINE  
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[PMID]:28105568
[Au] Autor:Chen CJ; Zhong ZF; Xin ZM; Hong LH; Su YP; Yu CX
[Ad] Endereço:Fujian Center for Safety Evaluation of New Drug, Fujian Medical University, Fuzhou, 350004, Fujian, People's Republic of China.
[Ti] Título:Koumine exhibits anxiolytic properties without inducing adverse neurological effects on functional observation battery, open-field and Vogel conflict tests in rodents.
[So] Source:J Nat Med;71(2):397-408, 2017 Apr.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Koumine, an active alkaloid of neurotoxic plant Gelsemium, has been focused on its therapeutic uses, especially in central nervous system. Nevertheless, less is known about the neurological effects of koumine, which hampers its potential therapeutic exploitation. Moreover, as the anxiolytic potential of Gelsemium has raised many critical issues, its active principles on the anxiolytic and other neurological effects need to be further investigated. Here, we used functional observation battery (FOB) of mice to systematically measure the neurological effects of koumine at the effective doses, and then further confirmed its anxiolytic properties in open-field test (OFT) of mice and Vogel conflict test (VCT) of rats. Koumine exhibited anxiolytic-like activities but did not affect other autonomic, neurological and physical functions in FOB. Furthermore, koumine released anxiolytic responses and anti-punishment action in a manner similar to diazepam in OFT and VCT, respectively. The results constitutes solid set of fundamental data further demonstrating anxiolytic properties of koumine at the therapeutic doses without inducing adverse neurological effects, which supports the perspectives for the development of safe and effective koumine medicine against pathological anxiety.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Ansiedade/tratamento farmacológico
Gelsemium/química
Alcaloides de Indol/uso terapêutico
Plantas/química
[Mh] Termos MeSH secundário: Animais
Alcaloides de Indol/farmacologia
Masculino
Camundongos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Indole Alkaloids); 0 (koumine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-017-1070-0


  5 / 81 MEDLINE  
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[PMID]:27765776
[Au] Autor:Adler LS; Leege LM; Irwin RE
[Ad] Endereço:Department of Biology, 221 Morrill Science Center South, 611 N. Pleasant St., University of Massachusetts, Amherst, Massachusetts 01003 USA lsadler@bio.umass.edu.
[Ti] Título:Geographic variation in resistance to nectar robbing and consequences for pollination.
[So] Source:Am J Bot;103(10):1819-1828, 2016 Oct.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Floral evolution is frequently ascribed to selection by pollinators, but may also be shaped by antagonists. However, remarkably few studies have examined geographic mosaics in resistance to floral antagonists or the consequences for other floral interactions. METHODS: Gelsemium sempervirens experiences frequent nectar robbing in northern Georgia, but rarely in southern Georgia. We conducted common-garden experiments in both locations using genotypes from each region and measured robbing, pollinator attraction, floral attractive and defensive traits, and plant reproduction. KEY RESULTS: Nectar robbing was more than four times higher in the north vs. south, and pollinator visits did not differ between gardens. Across both gardens, northern genotypes were half as likely to be nectar-robbed but received half as many pollinator visits as southern genotypes, suggesting evolution of resistance to robbing at a cost of reduced pollinator attraction. Plant-level traits, such as height and number of flowers, were more closely associated with resistance to robbing than floral size, shape, or chemistry. Northern genotypes had lower female and estimated male reproduction compared to southern genotypes at both locations, which could be due to costs of resistance to nectar robbing, or costs of adaptations to other biotic or abiotic differences between regions. CONCLUSIONS: Our study indicates that geographic variation can play a strong role structuring interactions with floral antagonists and mutualists and provides evidence consistent with the hypothesis that local resistance to nectar robbing imposes costs in terms of decreased pollinator attraction and reproduction.
[Mh] Termos MeSH primário: Evolução Biológica
Gelsemium/fisiologia
Insetos/fisiologia
Polinização
Simbiose
[Mh] Termos MeSH secundário: Distribuição Animal
Animais
Flores/fisiologia
Georgia
Néctar de Plantas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Nectar)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


  6 / 81 MEDLINE  
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[PMID]:27657857
[Au] Autor:Yang J; Cai HD; Zeng YL; Chen ZH; Fang MH; Su YP; Huang HH; Xu Y; Yu CX
[Ad] Endereço:Department of Pharmacology and ‡Fujian Key Laboratory of Natural Medicine Pharmacology, College of Pharmacy, Fujian Medical University , Fuzhou, Fujian 350108, China.
[Ti] Título:Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats.
[So] Source:J Nat Prod;79(10):2635-2643, 2016 Oct 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To examine the effect of koumine, a Gelsemium alkaloid, on two experimental models of rheumatoid arthritis (RA), rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) were administered koumine (0.6, 3, or 15 mg/kg/day) or vehicle through gastric gavage (i.g.). Clinical evaluation was performed via measurements of hind paw volume, arthritis index (AI) score, mechanical withdrawal threshold, organ weight, and by radiographic and histological examinations. Levels of interleukin (IL)-1ß, tumor necrosis factor (TNF)-α, and antitype II collagen (CII) antibody were also examined. In rats with AIA, koumine reduced the AI score and mechanical allodynia of the injected hind paw in a dose-dependent manner and significantly inhibited increase in thymus and liver weights. In rats with CIA, koumine inhibited increase in hind paw volume, AI score, and mechanical allodynia in a dose-dependent manner and reduced joint space narrowing. Furthermore, koumine also attenuated the increase in the expression of IL-1ß and TNF-α, as well as the robust increase of serum anti-CII antibodies in response to immunization. These results suggested that koumine effectively attenuated arthritis progression in two rat models of RA and that this therapeutic effect may be associated with its immunoregulatory action.
[Mh] Termos MeSH primário: Artrite Reumatoide/imunologia
Colágeno/farmacologia
Gelsemium/química
Alcaloides de Indol/farmacologia
[Mh] Termos MeSH secundário: Animais
Artrite Experimental
Artrite Reumatoide/tratamento farmacológico
Citocinas/análise
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Edema/tratamento farmacológico
Feminino
Alcaloides de Indol/química
Interleucina-1beta/análise
Masculino
Metotrexato/farmacologia
Estrutura Molecular
Ratos
Ratos Endogâmicos Lew
Ratos Wistar
Fator de Necrose Tumoral alfa/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Indole Alkaloids); 0 (Interleukin-1beta); 0 (Tumor Necrosis Factor-alpha); 0 (koumine); 9007-34-5 (Collagen); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


  7 / 81 MEDLINE  
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[PMID]:27329944
[Au] Autor:Carper AL; Adler LS; Irwin RE
[Ad] Endereço:Department of Biological Sciences, Dartmouth College, 78 College St., Hanover, New Hampshire 03755 USA adrian.l.carper@colorado.edu.
[Ti] Título:Effects of florivory on plant-pollinator interactions: Implications for male and female components of plant reproduction.
[So] Source:Am J Bot;103(6):1061-70, 2016 06.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Florivory could have direct negative effects on plant fitness due to consumption of floral organs, and indirect effects mediated through changes in traits important to pollination. These effects likely vary with plant sexual system, depending on sex- or morph-specific patterns of damage. We investigated the direct and indirect effects of simulated florivory on male and female components of reproduction in the native, distylous vine Gelsemium sempervirens. METHODS: We crossed floral damage and supplemental pollination treatments in a common garden array and tracked pollinator behavioral responses. We also estimated male function using fluorescent dye as an analog for pollen transfer, and measured both fruit and seed production. KEY RESULTS: The effects of floral damage varied by floral morph, the genus of floral visitor, and the component of reproduction measured. Damage reduced the number of pollinator visits to pin but not thrum plants, and increased the time some pollinators spent per flower in thrum but not pin plants. Flowers of damaged plants transferred more dye particles to recipient plants compared to undamaged plants, but only later in the season when the majority of dye transfer occurred. Damage had no effect on female reproduction. CONCLUSION: These results suggest that florivory can have positive indirect effects on estimated male plant reproduction through changes in different pollinators' behavior at flowers, but the effects of floral damage vary with male vs. female function. These results underscore the importance of other species' interactions at flowers in driving pollinator behavior and pollen transfer dynamics.
[Mh] Termos MeSH primário: Comportamento Alimentar/fisiologia
Flores/fisiologia
Gelsemium/fisiologia
Insetos/fisiologia
Polinização/fisiologia
[Mh] Termos MeSH secundário: Animais
Corantes/metabolismo
Fluorescência
Reprodução/fisiologia
Sementes/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coloring Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1600144


  8 / 81 MEDLINE  
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[PMID]:26388157
[Au] Autor:Wu YE; Li YD; Luo YJ; Wang TX; Wang HJ; Chen SN; Qu WM; Huang ZL
[Ad] Endereço:State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
[Ti] Título:Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice.
[So] Source:Acta Pharmacol Sin;36(11):1308-17, 2015 Nov.
[Is] ISSN:1745-7254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans (Gardn & Champ) Benth., is effective in mitigating chronic pain in rats. In the present study we investigated whether the alkaloid improved sleep disturbance, the most common comorbid symptoms of chronic pain, in a mouse model of neuropathic pain. METHODS: Mice were subjected to partial sciatic nerve ligation (PSNL). After the mice were injected with gelsemine or pregabalin (the positive control) intraperitoneally, mechanical allodynia and thermal hyperalgesia were assessed, and electroencephalogram (EEG)/electromyogram (EMG) recording was performed. Motor performance of the mice was assessed using rota-rod test. c-Fos expression in the brain was analyzed with immunohistochemical staining. RESULTS: In PSNL mice, gelsemine (2 and 4 mg/kg) increased the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, gelsemine (4 mg/kg, administered at 6:30 AM) increased non-rapid eye movement (non-REM, NREM) sleep, decreased wakefulness, but did not affect REM sleep during the first 3 h in PSNL mice. Sleep architecture analysis showed that gelsemine decreased the mean duration of wakefulness and increased the total number of episodes of NREM sleep during the first 3 h after the dosing. Gelsemine (4 mg/kg) did not impair motor coordination in PSNL mice. Immunohistochemical study showed that PSNL increased c-Fos expression in the neurons of the anterior cingulate cortex, and gelsemine (4 mg/kg) decreased c-Fos expression by 58%. Gelsemine (4 mg/kg, administered at either 6:30 AM or 8:30 PM) did not produce hypnotic effect in normal mice. Pregabalin produced similar antinociceptive and hypnotic effects, but impaired motor coordination in PSNL mice. CONCLUSION: Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in PSNL mice; anterior cingulate cortex might play a role in the hypnotic effects of gelsemine.
[Mh] Termos MeSH primário: Alcaloides/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Hiperalgesia/tratamento farmacológico
Hipnóticos e Sedativos/uso terapêutico
Neuralgia/tratamento farmacológico
Transtornos do Sono-Vigília/tratamento farmacológico
[Mh] Termos MeSH secundário: Alcaloides/química
Animais
Modelos Animais de Doenças
Medicamentos de Ervas Chinesas/química
Gelsemium/química
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Nervo Isquiático/cirurgia
Sono/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Drugs, Chinese Herbal); 0 (Hypnotics and Sedatives); 5Y13A78Z72 (gelsemine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150922
[St] Status:MEDLINE
[do] DOI:10.1038/aps.2015.86


  9 / 81 MEDLINE  
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[PMID]:26344425
[Au] Autor:Wu HR; He XF; Jin XJ; Pan H; Shi ZN; Xu DD; Yao XJ; Zhu Y
[Ad] Endereço:State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
[Ti] Título:New nor-ursane type triterpenoids from Gelsemium elegans.
[So] Source:Fitoterapia;106:175-83, 2015 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new nor-ursane type triterpenoids, gelse-norursane A-E, together with twenty known compounds, were isolated from the whole plant of Gelsemium elegans. The structures of new compounds were established as (2R,3R,7R,17S,19R)-2,3,7,19-tetrahydroxy-6-oxo-24-norurs-4(23),12-dien-28-oic acid (1), (2R,3R,7R,17S)-2,3,7-trihydroxy-6-oxo-24-norurs-4(23), 12-dien-28-oic acid (2), (2R,3R,7R,17S)-2,3,4-trihydroxy-23-norurs-20(30),12-dien-28-oic acid (3), (2R,3R,30R)-2,3-dihydroxy-24-norurs-4(23),12-dien-30-oic acid (4), and (2R,3R,30R)-2, 3-dihydroxy-24-norurs-4,12-dien-30-oic acid (5), using spectroscopic analysis, including HRESIMS, 1D and 2D NMR. The absolute configurations of 1 and 4 were established through comparison of experimental and calculated ECD spectra. The gelse-norursane A-E are isolated as the 24-nor-ursane type triterpenoids from the family Loganiaceae for the first time. The cytotoxicities of the selected compounds against a panel of four human cancer HL60, Hela, Hep-G2, and Smmc 7221 cell lines were evaluated using the MTT assay in vitro.
[Mh] Termos MeSH primário: Gelsemium/química
Triterpenos/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Seres Humanos
Estrutura Molecular
Extratos Vegetais/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Triterpenes)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151009
[Lr] Data última revisão:
151009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150908
[St] Status:MEDLINE


  10 / 81 MEDLINE  
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[PMID]:26241103
[Au] Autor:Liu Y; Li Y; Qu J; Ma S; Zang C; Zhang Y; Yu S
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
[Ti] Título:Eremophilane Sesquiterpenes and Polyketones Produced by an Endophytic Guignardia Fungus from the Toxic Plant Gelsemium elegans.
[So] Source:J Nat Prod;78(9):2149-54, 2015 Sep 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A cultured endophytic fungus, Guignardia mangiferae, isolated from the toxic plant Gelsemium elegans yielded five new sesquiterpenes (1-5), two new polyketones (6 and 7), and two known terpene polyketones (8 and 9). Their structures were elucidated using spectroscopic methods. On the basis of circular dichroism, the absolute configurations of the new compounds were determined. Compounds 1, 3, 4, and 9 inhibited lipopolysaccharide-induced NO production in BV2 cells with IC50 values of 15.2, 6.4, 4.2, and 4.5 µM, respectively (positive control curcumin, IC50 = 3.9 µM).
[Mh] Termos MeSH primário: Endófitos/química
Gelsemium/microbiologia
Plantas Tóxicas/microbiologia
Sesquiterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Cetonas/química
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ketones); 0 (Sesquiterpenes)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150925
[Lr] Data última revisão:
150925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150805
[St] Status:MEDLINE
[do] DOI:10.1021/np5009027



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde