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Pesquisa : B01.650.940.800.575.912.250.456.875.750 [Categoria DeCS]
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[PMID]:28056932
[Au] Autor:Fentahun S; Makonnen E; Awas T; Giday M
[Ad] Endereço:Wollo University, P.O. Box 1145, Dessie, Ethiopia.
[Ti] Título:In vivo antimalarial activity of crude extracts and solvent fractions of leaves of Strychnos mitis in Plasmodium berghei infected mice.
[So] Source:BMC Complement Altern Med;17(1):13, 2017 Jan 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Malaria is a major public health problem in the world which is responsible for death of millions particularly in sub-Saharan Africa. Today, the control of malaria has become gradually more complex due to the spread of drug-resistant parasites. Medicinal plants are the unquestionable source of effective antimalarials. The present study aimed to evaluate antiplasmodial activity and acute toxicity of the plant Strychnos mitis in Plasmodium berghei infected mice. METHODS: Standard procedures were employed to investigate acute toxicity and 4-day suppressive effect of crude aqueous and hydro-methanolic extracts of the leaves of Strychnos mitis against P. berghei in Swiss albino mice. Water, n-hexane and chloroform fractions, obtained from crude hydro-methanolic extract, were also tested for their suppressive effect against P. berghei. RESULTS: All crude extracts revealed no obvious acute toxicity in mice up to the highest dose administered (2000 mg/kg). All crude and solvent fractions of the leaves of Strychnos mitis inhibited parasitaemia significantly (p < 0.01). At the highest dose of 600 mg/kg, both aqueous and hydro-methanolic extracts demonstrated higher performance with 95.5 and 93.97% parasitaemia suppression, respectively. All doses of crude extracts and fractions of leaves of Strychnos mitis prolonged survival time of infected mice dose dependently. The highest two doses of the crude aqueous and hydro-methanolic extracts, and chloroform and aqueous fractions prevented weight loss in a dose dependent manner. Whereas, all doses of n-hexane fraction prevented loss of body weight but not in a dose dependent manner. The crude aqueous extract at the doses of 400 mg/kg and 600 mg/kg and hydro-methanolic extract at all dose levels significantly (p < 0.01) prevented packed cell volume reduction. Crude aqueous extract at a dose of 600 mg/kg and hydro-methanolic extract at all dose levels significantly prevented temperature reduction. Phytochemical screening of the crude aqueous and hydro-methanolic extracts revealed the presence of alkaloids, anthraquinones, glycosides, terpenoids, saponins, tannins and phenols. CONCLUSION: The results of this study provide support the traditional therapeutic use of Strychnos mitis for treatment of malaria. However, further in-depth study is needed to evaluate the potential of the plant towards the development of new antimalarial agent.
[Mh] Termos MeSH primário: Antimaláricos/administração & dosagem
Malária/parasitologia
Extratos Vegetais/administração & dosagem
Plasmodium berghei/efeitos dos fármacos
Strychnos/química
[Mh] Termos MeSH secundário: Animais
Antimaláricos/química
Antimaláricos/isolamento & purificação
Seres Humanos
Malária/tratamento farmacológico
Masculino
Camundongos
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Plasmodium berghei/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1529-7


  2 / 114 MEDLINE  
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[PMID]:27545867
[Au] Autor:Sichaem J; Ingkaninan K; Tip-Pyang S
[Ad] Endereço:a Natural Products Research Unit, Faculty of Science, Department of Chemistry , Chulalongkorn University , Bangkok , Thailand.
[Ti] Título:A novel pyrrole alkaloid from the fruit peels of Strychnos nux-blanda.
[So] Source:Nat Prod Res;31(2):149-154, 2017 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel pyrrole alkaloid, strychnuxin (1), along with five known compounds (2-6) was isolated from the fruit peels of Strychnos nux-blanda. The structures of all the isolated compounds (1-6) were fully characterised using spectroscopic data, as well as comparison with the previous literature data. Moreover, all isolated compounds were assessed for their α-glucosidase and acetylcholinesterase inhibitory activities.
[Mh] Termos MeSH primário: Frutas/química
Pirróis/química
Pirróis/farmacologia
Strychnos/química
[Mh] Termos MeSH secundário: Inibidores da Colinesterase/química
Inibidores da Colinesterase/farmacologia
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Extratos Vegetais/química
Sementes/química
Espectrometria de Massas por Ionização por Electrospray
Espectrofotometria Ultravioleta
Tailândia
alfa-Glucosidases
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Enzyme Inhibitors); 0 (Plant Extracts); 0 (Pyrroles); 0 (strychnuxin); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE


  3 / 114 MEDLINE  
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[PMID]:28480356
[Au] Autor:Ai I; Jp D; Sa A; Mm S; Jn E
[Ad] Endereço:Phytomedicine Programme, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa.
[Ti] Título:NITRIC OXIDE INHIBITORY ACTIVITY OF (LOGANIACEAE) LEAF EXTRACTS AND FRACTIONS.
[So] Source:Afr J Tradit Complement Altern Med;13(6):22-26, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The study was aimed at determining the anti-inflammatory activity of fractions and extracts obtained from leaves on a mediator of inflammation nitric oxide (NO). MATERIALS AND METHODS: Leaves were extracted with acetone and separated into fractions with different polarities by solvent-solvent fractionation. The Griess assay was used to determine the nitric oxide (NO) inhibitory activity. Cellular toxicity was determined by "using the MTT reduction assay". RESULTS: With the exception of the ethyl acetate fraction which had an IC >750 µg/mL, all extracts and fractions had significant nitric oxide-inhibitory activity. The most active being the water fraction, chloroform fraction and the dichloromethane/methanol extracts with IC values of 88.43 µg/mL, 96.72 µg/mL and 115.62 µg/mL, respectively. The extracts and fractions had low cytotoxicity on macrophage U937 cell lines. CONCLUSION: Extracts and fractions of leaves may be promising sources of natural anti-inflammatory agents. Findings obtained from this study showed that leaves possess promising anti-inflammatory action and could be used in the treatment of inflammation-related conditions.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Óxido Nítrico/antagonistas & inibidores
Extratos Vegetais/farmacologia
Folhas de Planta/química
Strychnos/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Fracionamento Químico/métodos
Seres Humanos
Extratos Vegetais/química
Células U937
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i6.5


  4 / 114 MEDLINE  
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[PMID]:27718041
[Au] Autor:Adebowale A; Lamb J; Nicholas A; Naidoo Y
[Ad] Endereço:School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Private Bag 3, Wits, Johannesburg, 2050, South Africa. Strychnos009@gmail.com.
[Ti] Título:ITS2 secondary structure for species circumscription: case study in southern African Strychnos L. (Loganiaceae).
[So] Source:Genetica;144(6):639-650, 2016 Dec.
[Is] ISSN:1573-6857
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Recently developed computational tools in ITS2 sequence-structure phylogenetics are improving tree robustness by exploitation of the added information content of the secondary structure. Despite this strength, however, their adoption for species-level clarifications in angiosperms has been slow. We investigate the utility of combining ITS2 sequence and secondary structure to separate species of southern African Strychnos, and assess correlation between compensatory base changes (CBCs) and currently recognised species boundaries. Combined phylogenetic analysis of sequence and secondary structure datasets performed better, in terms of robustness and species resolution, than analysis involving primary sequences only, achieving 100 and 88.2 % taxa discriminations respectively. Further, the Strychnos madagascariensis complex is well-resolved by sequence-structure phylogenetic analysis. The 17 Strychnos species corresponded to 14 ITS2 CBC clades. Four of the five taxa in section Densiflorae belong to a single CBC clade, whose members tend to form natural hybrids. Our finding supports the application of ITS2 as a complementary barcoding marker for species identification. It also highlights the potential of comparative studies of ITS2 CBC features among prospective parental pairs in breeding experiments as a rapid proxy for cross compatibility assessment. This could save valuable time in crop improvement. Patterns of CBC evolution and species boundaries in Strychnos suggests a positive correlation. We conclude that the CBC pattern coupled with observed ITS2 sequence paraphyly in section Densiflorae points to a speciation work-in-progress.
[Mh] Termos MeSH primário: DNA Intergênico/genética
Strychnos/classificação
Strychnos/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Evolução Molecular
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Intergenic)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


  5 / 114 MEDLINE  
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[PMID]:27592135
[Au] Autor:Jiang H; Ma SG; Li Y; Liu YB; Li L; Qu J; Yu SS
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
[Ti] Título:Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.
[So] Source:Bioorg Med Chem Lett;26(19):4832-4836, 2016 10 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three new spirobisnaphthalenes (1-3), a new, natural spirobisnaphthalene product (4), and two new 12-membered ring lactones (11-12), with six known compounds (5-10), were isolated from the seeds of Strychnos angustiflora. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1-4 were assigned by computational methods. Compounds 1, 5 and 9 inhibited lipopolysaccharide-induced NO production in BV2 cells with IC50 values of 4.85, 2.05, and 1.16µM, respectively (positive control curcumin, IC50=1.42µM). This is the first report on the anti-inflammatory activities of spirobisnaphthalenes.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Naftalenos/isolamento & purificação
Naftalenos/farmacologia
Sementes/química
Strychnos/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Concentração Inibidora 50
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Naphthalenes)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160905
[St] Status:MEDLINE


  6 / 114 MEDLINE  
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[PMID]:27566664
[Au] Autor:Boff L; Silva IT; Argenta DF; Farias LM; Alvarenga LF; Pádua RM; Braga FC; Leite JP; Kratz JM; Simões CM
[Ad] Endereço:Laboratório de Virologia Aplicada, Programa de Pós-graduação em Farmácia, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
[Ti] Título:Strychnos pseudoquina A. St. Hil.: a Brazilian medicinal plant with promising in vitro antiherpes activity.
[So] Source:J Appl Microbiol;121(6):1519-1529, 2016 Dec.
[Is] ISSN:1365-2672
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To investigate the anti-HSV and anti-inflammatory effects of a standardized ethyl acetate extract (SEAE) prepared with the stem bark of Strychnos pseudoquina, along with two isolated compounds: quercetin 3-O-methyl ether (3MQ) and strychnobiflavone (SBF). METHODS AND RESULTS: The mechanisms of action were evaluated by different methodological strategies. SEAE and SBF affected the early stages of viral infection and reduced HSV-1 protein expression. Both flavonoids elicited a concentration-dependent inhibition of monocyte chemoattractant protein-1 (MCP-1), whereas 3MQ reduced the chemokine release more significantly than SBF. Conversely, both compounds stimulated the production of the cytokines TNF-α and IL-1-ß in LPS-stimulated cells, especially at the intermediate and the highest tested concentrations. CONCLUSIONS: SEAE and SBF interfered with various steps of HSV replication cycle, mainly adsorption, postadsorption and penetration, as well as with ß and γ viral proteins expression; moreover, a direct inactivation of viral particles was observed. Besides, both flavonoids inhibited MCP-1 selectively, a feature that may be beneficial for the development of new anti-HSV agents. SIGNIFICANCE AND IMPACT OF THE STUDY: The results indicated that the samples present anti-HSV and anti-inflammatory activities, at different levels, which is an interesting feature since cold and genital sores are accompanied by an inflammation process.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Biflavonoides/farmacologia
Herpesvirus Humano 1/efeitos dos fármacos
Quercetina/análogos & derivados
Strychnos/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Antivirais/química
Biflavonoides/química
Brasil
Linhagem Celular
Cercopithecus aethiops
Quimiocina CCL2/metabolismo
Citocinas/metabolismo
Herpesvirus Humano 1/fisiologia
Seres Humanos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
Quercetina/química
Quercetina/farmacologia
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antiviral Agents); 0 (Biflavonoids); 0 (Chemokine CCL2); 0 (Cytokines); 0 (Plant Extracts); 0 (quercetin 3-O-methyl ether); 0 (strychnobiflavone); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160828
[St] Status:MEDLINE
[do] DOI:10.1111/jam.13279


  7 / 114 MEDLINE  
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[PMID]:27534097
[Au] Autor:Sichaem J; Khumkratok S; Siripong P; Tip-pyang S
[Ti] Título:A New Non-glucosidic Iridoid from the Roots of Strychnos nux-blanda.
[So] Source:Nat Prod Commun;11(6):709-10, 2016 Jun.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Strychnuxin (1), a new non-glucosidic iridoid, together with four known compounds, IX (2), loganetin (3), loganin (4) and sweroside (5), were isolated from the roots of Strychnos nux-blanda. The structures of all isolated compounds (1-5) were elucidated through their physical properties and by the use of spectroscopic methods, as well as comparisons with the previous literature. To the best of our knowledge, this is the first isolation of compounds 1-5 from this plant. All isolated compounds were evaluated for their in vitro cytotoxicity against five human cancer cell lines.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Iridoides/química
Strychnos/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Seres Humanos
Iridoides/isolamento & purificação
Iridoides/farmacologia
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Iridoids)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160818
[Lr] Data última revisão:
160818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE


  8 / 114 MEDLINE  
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[PMID]:27002898
[Au] Autor:Maertens G; Canesi S
[Ad] Endereço:Laboratoire de Méthodologie et Synthèse de, Produit Naturels, Université du Québec à Montréal, C.P.8888, Succ. Centre-Ville, Montréal, H3C 3P8, Québec, Canada.
[Ti] Título:Synthesis of the Strychnos Alkaloid (-)-Strychnopivotine and Confirmation of its Absolute Configuration.
[So] Source:Chemistry;22(21):7090-3, 2016 05 17.
[Is] ISSN:1521-3765
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The first enantioselective synthesis of (-)-strychnopivotine from a known and inexpensive phenol has been achieved in 15 steps. The strategy is based on a new diastereoselective aza-Michael-enol-ether cascade desymmetrization of a dienone, guided by a removable lactic acid-derived chiral auxiliary. Synthesis involves a phenol dearomatization, a conjugated silicon addition, a stereoselective double reductive amination, and two Heck-type carbopalladations as key steps. The absolute configuration of the natural compound, which, to date, has been uncertain, was confirmed by using circular dichroism (CD) spectroscopy and X-ray analyses.
[Mh] Termos MeSH primário: Estricnina/análogos & derivados
Strychnos/química
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Modelos Moleculares
Conformação Molecular
Fenóis/síntese química
Fenóis/química
Estereoisomerismo
Estricnina/síntese química
Estricnina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Phenols); H9Y79VD43J (Strychnine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE
[do] DOI:10.1002/chem.201601319


  9 / 114 MEDLINE  
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[PMID]:26933928
[Au] Autor:Eckermann R; Gaich T
[Ad] Endereço:Institute of Organic Chemistry, Leibniz University of Hannover, Schneiderberg 1b, 30167, Hannover, Germany.
[Ti] Título:The Double-Bond Configuration of Corynanthean Alkaloids and Its Impact on Monoterpenoid Indole Alkaloid Biosynthesis.
[So] Source:Chemistry;22(16):5749-55, 2016 Apr 11.
[Is] ISSN:1521-3765
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Experimental evidence is provided for the coherence of the double-bond geometry and the occurrence of "secondary cyclizations" in the biosynthesis of monoterpenoid indole alkaloids. Biosynthetically, akuammiline, C-mavacurine, and Strychnos alkaloids are proposed to be derived from the corynanthean alkaloid geissoschizine, a key intermediate in the biosynthetic pathway of these monoterpenoid indole alkaloids. This process occurs by so-called "secondary cyclizations" from geissoschizine or its derivatives. Although corynanthean alkaloids like geissoschizine incorporate E or Z double bonds located at C19-C20, the alkaloids downstream in the biosynthesis exclusively exhibit the E double bond. This study shows that secondary cyclizations preferentially occur with the E isomer of geissoschizine or its derivatives. This is attributed to the flexibility of the quinolizidine system of the corynanthean alkaloids, which can adopt a cis or trans conformation. For the secondary cyclization to take place, the cis-quinolizidine conformation is required. Experimental evidence supports the hypothesis that the E double bond of geissoschizine induces the cis conformation, whereas the Z double bond induces the trans conformation, which prohibits secondary cyclization of the Z compounds.
[Mh] Termos MeSH primário: Alcaloides de Indol/química
Alcaloides de Triptamina e Secologanina/química
Strychnos/química
[Mh] Termos MeSH secundário: Fenômenos Bioquímicos
Vias Biossintéticas
Carbolinas
Ciclização
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbolines); 0 (Indole Alkaloids); 0 (Secologanin Tryptamine Alkaloids); 0 (corynanthean); 439-66-7 (geissoschizine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160303
[St] Status:MEDLINE
[do] DOI:10.1002/chem.201505068


  10 / 114 MEDLINE  
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[PMID]:26926777
[Au] Autor:Wyler B; Brucelle F; Renaud P
[Ad] Endereço:Universität Bern , Departement für Chemie und Biochemie, Freiestrasse 3, CH-3012 Bern, Switzerland.
[Ti] Título:Preparation of the Core Structure of Aspidosperma and Strychnos Alkaloids from Aryl Azides by a Cascade Radical Cyclization.
[So] Source:Org Lett;18(6):1370-3, 2016 Mar 18.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel approach to prepare the core structure of Aspidosperma and Strychnos alkaloids is described. The strategy is based on a cyclization cascade involving the formation of quaternary carbon center followed by trapping of the radical intermediate by an aryl azide to build the 5-membered ring of the pyrrolocarbazole system. This reaction is run with triethylborane without the need for any hydrogen atom donor such as a tin hydride or tris(trimethylsilyl)silane, and it furnishes the tetracyclic framework as a single diastereomer. The influence of different N-protecting groups on the starting iodoacetamide has been examined.
[Mh] Termos MeSH primário: Alcaloides/síntese química
Aspidosperma/química
Azidas/química
Strychnos/química
[Mh] Termos MeSH secundário: Alcaloides/química
Catálise
Ciclização
Alcaloides de Indol/síntese química
Alcaloides de Indol/química
Iodoacetamida/química
Estrutura Molecular
Quinolinas/síntese química
Quinolinas/química
Estereoisomerismo
Estricnina/síntese química
Estricnina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Azides); 0 (Indole Alkaloids); 0 (Quinolines); 0 (aspidospermidine); H9Y79VD43J (Strychnine); ZRH8M27S79 (Iodoacetamide)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160318
[Lr] Data última revisão:
160318
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.1021/acs.orglett.6b00306



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