Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.456.937.388 [Categoria DeCS]
Referências encontradas : 302 [refinar]
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[PMID]:29406030
[Au] Autor:Zhang X; Pi Z; Zheng Z; Liu Z; Song F
[Ad] Endereço:National Center of Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100039, China.
[Ti] Título:Comprehensive investigation of in-vivo ingredients and action mechanism of iridoid extract from Gardeniae Fructus by liquid chromatography combined with mass spectrometry, microdialysis sampling and network pharmacology.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1076:70-76, 2018 Feb 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Gardeniae Fructus is a widely used Traditional Chinese Medicines in treating various diseases. However, the absorbed components and metabolites of its main bioactive iridoid ingredients from iridoid extract of the fruits of Gardeniae Fructus in rat plasma need further study. In this study, a systematic method based on ultra-performance liquid chromatography-quadrupole-time-of-flight/mass spectrometry (UPLC-Q-TOF/MS) technique was developed to speculate the absorbed components and metabolites of iridoid extract in rat plasma after oral administration. A total of 19 compounds, including 9 prototype components and 10 metabolites were identified in plasma. 5 metabolites containing 4 new metabolites (M1, M2, M7, M10) were tentatively determined in rat plasma. Besides, Microdialysis-intensity-fading mass spectrometry (MD-IF-MS) method was originally employed to reveal the binding affinities with α-glucosidase for in-vivo prototype components and their metabolites. Finally, the absorbed constituents and the corresponding target proteins were used to generate compound-target network to find the related diseases and action pathways by a network pharmacology method. The results provide useful information for further study of pharmacology and in vivo mechanism of action of iridoid extract from the fruits of Gardeniae Fructus.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Gardenia/química
Iridoides/sangue
Iridoides/metabolismo
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Animais
Frutas/química
Masculino
Microdiálise
Extratos Vegetais/metabolismo
Ratos
Ratos Sprague-Dawley
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoids); 0 (Plant Extracts)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:28754101
[Au] Autor:Park JY; Kwon YW; Lee SC; Park SD; Lee JH
[Ad] Endereço:College of Korean Medicine, Dongguk University, Goyang, 10326, Republic of Korea.
[Ti] Título:Herbal formula SC-E1 suppresses lipopolysaccharide-stimulated inflammatory responses through activation of Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages.
[So] Source:BMC Complement Altern Med;17(1):374, 2017 Jul 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: SC-E1 is a novel herbal formula consisting of five oriental medicinal herbs used frequently in traditional herbal medicine for the treatment of inflammatory diseases in Korea. This study examined the effects of SC-E1 on lipopolysaccharide (LPS)-stimulated macrophages and the molecular mechanism involved. METHODS: The cytotoxic effect of the SC-E1 extract was evaluated in RAW 264.7 cells by MTT assay. The effects of SC-E1 on the free radical scavenging and generation of intracellular reactive oxygen species were measured using DPPH and DCFH-DA, respectively. The effects of SC-E1 on the production of pro-inflammatory cytokines, inflammatory mediators, and related products were determined by ELISA and western blotting. The molecular mechanism and the nuclear translocation of nuclear factor-kappa B (NF-κB) and NF-E2-related factor 2 (Nrf2) were examined by western blot analysis and immunocytochemistry. RESULTS: SC-E1 exhibited strong anti-oxidant activity and inhibited LPS-induced NO secretion as well as iNOS expression and the production of pro-inflammatory cytokines, without affecting the cell viability. SC-E1 also suppressed the LPS-induced NF-κB activation and the mitogen-activated protein kinase (MAPK) pathway. Moreover, SC-E1 induced heme oxygenase-1 (HO-1) expression via the nuclear translocation of Nrf2. The inhibitory effects of SC-E1 on the production of pro-inflammatory cytokines were abrogated by treatment with SnPP, an HO-1 inhibitor. CONCLUSION: These results suggest that SC-E1 exerts its anti-oxidant and anti-inflammatory effects through the inhibition of NF-κB and MAPK as well as Nrf2-mediated HO-1 induction in macrophages. These findings provide evidences for SC-E1 to be considered as a new prescription for treating inflammatory diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Heme Oxigenase-1/metabolismo
Inflamação/metabolismo
Magnoliopsida
Proteínas de Membrana/metabolismo
Fator 2 Relacionado a NF-E2/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Compostos de Bifenilo/metabolismo
Citocinas/metabolismo
Fluoresceínas/metabolismo
Gardenia
Glycyrrhiza
Inflamação/induzido quimicamente
Inflamação/tratamento farmacológico
Lipopolissacarídeos
Medicina Tradicional Coreana
Camundongos
NF-kappa B/metabolismo
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo II/metabolismo
Picratos/metabolismo
Extratos Vegetais/uso terapêutico
Platycodon
Pueraria
Células RAW 264.7
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Cytokines); 0 (Fluoresceins); 0 (Lipopolysaccharides); 0 (Membrane Proteins); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Nfe2l2 protein, mouse); 0 (Picrates); 0 (Plant Extracts); 2044-85-1 (diacetyldichlorofluorescein); 31C4KY9ESH (Nitric Oxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170730
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1874-1


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[PMID]:28631356
[Au] Autor:Zhang ZR; Wu H; Wang R; Li SP; Dai L; Wang WY
[Ad] Endereço:Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei, 230012, China.
[Ti] Título:Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats.
[So] Source:Phytother Res;31(8):1249-1256, 2017 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Rheumatoid arthritis (RA) is a systemic, Th1 cytokine-predominant autoimmune disease result in a chronic and inflammatory disorder. Geniposide (GE), an iridoid glycoside compound that is purified from Gardenia jasminoides Ellis, has antiinflammatory and other immunoregulatory effects, but its exact mechanism of actions on RA is unknown. The aim of this study was to elucidate antiinflammation effects of GE on adjuvant arthritis (AA) rats and its possible immune tolerance mechanisms. Male Sprague-Dawley rats were administered with GE (30, 60, and 120 mg/kg) orally from day 17 to 24 after immunization. Lymphocyte proliferation was assessed by MTT. Levels of interleukin-2 (IL-2), IL-4, and transforming growth factor-ß1 were tested by ELISA. The expression of ß2-AR, GRK2, and ß-arrestin-1 and ß-arrestin-2 was detected by western blot. Geniposide was found to relieve the secondary hind paw swelling and arthritis scores, along with attenuating histopathologic changes and decreasing IL-2 and increasing IL-4, transforming growth factor-ß1 in mesenteric lymph node (MLN) lymphocytes of AA rats. In addition, GE in vivo increased the expression of ß2-AR and decreased the expression of GRK2, ß-arrestin-1 and ß-arrestin-2, and level of cyclic adenosine monophosphate of MLN lymphocytes in AA rats. From these results, we can infer that GE on immune tolerance effects, ß2-AR desensitization, and ß2-AR-AC-cyclic adenosine monophosphate transmembrane signal transduction of MLN lymphocytes plays crucial roles in antiinflammatory and immunoregulatory pathogeneses of RA. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Artrite Experimental/tratamento farmacológico
Tolerância Imunológica/efeitos dos fármacos
Iridoides/farmacologia
Linfócitos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Artrite Reumatoide
Proliferação Celular/efeitos dos fármacos
AMP Cíclico/metabolismo
Quinase 2 de Receptor Acoplado a Proteína G/metabolismo
Gardenia/química
Interleucina-2/imunologia
Interleucina-4/imunologia
Linfonodos/citologia
Masculino
Ratos
Ratos Sprague-Dawley
Transdução de Sinais/efeitos dos fármacos
Fator de Crescimento Transformador beta1/imunologia
beta-Arrestina 1/metabolismo
beta-Arrestina 2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Arrb1 protein, rat); 0 (Arrb2 protein, rat); 0 (Interleukin-2); 0 (Iridoids); 0 (Tgfb1 protein, rat); 0 (Transforming Growth Factor beta1); 0 (beta-Arrestin 1); 0 (beta-Arrestin 2); 145295QLXY (geniposide); 207137-56-2 (Interleukin-4); E0399OZS9N (Cyclic AMP); EC 2.7.11.15 (Adrbk1 protein, rat); EC 2.7.11.16 (G-Protein-Coupled Receptor Kinase 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5847


  4 / 302 MEDLINE  
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[PMID]:28488862
[Au] Autor:Tshitenge DT; Feineis D; Awale S; Bringmann G
[Ad] Endereço:Institute of Organic Chemistry, University of Würzburg , Am Hubland, D-97074 Würzburg, Germany.
[Ti] Título:Gardenifolins A-H, Scalemic Neolignans from Gardenia ternifolia: Chiral Resolution, Configurational Assignment, and Cytotoxic Activities against the HeLa Cancer Cell Line.
[So] Source:J Nat Prod;80(5):1604-1614, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:From the tropical plant Gardenia ternifolia Schumach. and Thonn. (Rubiaceae), eight stereoisomeric 2,3-dihydrobenzo[b]furan neolignans, named gardenifolins A-H (1a-d and 2a-d), were isolated and fully structurally characterized. Reversed-phase chromatography of a stem bark extract afforded two peaks, viz. mixtures I and II, each one consisting of two diastereomers and their respective enantiomers. They were resolved and stereochemically analyzed by HPLC on a chiral phase coupled to electronic circular dichroism (ECD) spectroscopy, giving single ECD spectra of all eight stereoisomers. The double-bond geometries (E or Z) of the gardenifolins A-H and their relative configurations (cis or trans) at the stereogenic centers C-7 and C-8 in the dihydrofuran ring system were assigned by 1D and 2D NMR methods, in particular, using NOE difference experiments, whereas the absolute configurations of the isolated enantiomers were established by ECD spectroscopy by applying the reversed helicity rule. The individual pure gardenifolin isomers A-H showed the most different cytotoxic effects against the human cancer HeLa cell line, with 1d and 2a displaying the highest activities, with IC values of 21.0 and 32.5 µM, respectively. Morphological experiments indicated that gardenifolin D (1d) induces apoptosis of HeLa cells at 25 µM.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Gardenia/química
Lignanas/isolamento & purificação
Lignanas/farmacologia
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Dicroísmo Circular
Cristalografia por Raios X
Células HeLa
Seres Humanos
Lignanas/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans); 0 (gardenifolin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00180


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[PMID]:28477916
[Au] Autor:Shin JK; Lee SM
[Ad] Endereço:School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
[Ti] Título:Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control.
[So] Source:Toxicol Appl Pharmacol;328:25-33, 2017 Aug 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hepatic ischemia and reperfusion (IR) injury is closely linked to oxidative mitochondrial damage. Since mitochondrial quality control (QC) plays a pivotal role in the recovery of impaired mitochondrial function, mitochondrial QC has emerged as a potential therapeutic target. Genipin, an iridoid compound from Gardenia jasminoides, has been showed antioxidant and anti-inflammatory properties. In this study, we investigated the hepatoprotective mechanism of genipin against IR-induced hepatic injury, particularly focusing on mitochondrial QC. Male C57BL/6 mice underwent liver ischemia for 60min, followed by reperfusion for 6h. Genipin (100mg/kg, i.p.) or vehicle (10% Tween 80 in saline) was administrated to mice 1h before ischemia. Liver and blood samples were collected 6h after reperfusion. Hepatic IR increased hepatocellular oxidative damage and induced mitochondrial dysfunction. These phenomena were ameliorated by genipin. Hepatic IR also increased the level of mitochondrial fission, such as dynamin-related protein 1 and the level of PINK1 protein expression. In contrast, hepatic IR decreased the levels of mitochondrial biogenesis related proteins (e.g., peroxisome proliferator-activated receptor gamma coactivator 1α, nuclear respiratory factor 1, and mitochondrial transcription factor A), mitophagy related proteins (e.g., Parkin), and fusion related protein (e.g., mitofusin 2). Furthermore, hepatic IR decreased the levels of sirtuin1 protein and phosphorylation of AMP-activated protein kinase. Genipin alleviated these IR-induced changes. These data indicate that genipin protects against IR-induced hepatic injury via regulating mitochondrial QC. (225/250).
[Mh] Termos MeSH primário: Iridoides/uso terapêutico
Hepatopatias/prevenção & controle
Mitocôndrias Hepáticas/efeitos dos fármacos
Substâncias Protetoras/uso terapêutico
Traumatismo por Reperfusão/prevenção & controle
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/metabolismo
Animais
Citocinas/sangue
Gardenia/química
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Dilatação Mitocondrial/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Controle de Qualidade
Transdução de Sinais/efeitos dos fármacos
Sirtuína 1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Iridoids); 0 (Protective Agents); A3V2NE52YG (genipin); EC 2.7.11.31 (AMP-Activated Protein Kinases); EC 3.5.1.- (Sirt1 protein, mouse); EC 3.5.1.- (Sirtuin 1)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


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[PMID]:28351695
[Au] Autor:Toppo E; Darvin SS; Esakkimuthu S; Stalin A; Balakrishna K; Sivasankaran K; Pandikumar P; Ignacimuthu S; Al-Dhabi NA
[Ad] Endereço:Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu 600 034, India.
[Ti] Título:Antihyperlipidemic and hepatoprotective effects of Gardenin A in cellular and high fat diet fed rodent models.
[So] Source:Chem Biol Interact;269:9-17, 2017 May 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The gum of Gardenia resinifera Roth., is one of the important drugs used in the Indian system of medicine and a source of unique polymethoxylated flavones. This study was aimed to evaluate the antihyperlipidemic and anti-NAFLD effects of Gardenin A (Gar-A) from G. resinifera gum using in vitro and in vivo models. Gar-A was isolated from G. resinifera gum and was identified on the basis of the physical and spectral data. Toxicity of Gar-A to HepG2 cells was evaluated using MTT assay. The ability of Gar-A to reduce steatosis was assessed using oleate-palmitate induced HepG2 cell lines by estimating the lipid levels by ORO staining and by estimating the intracellular triglyceride content. Effect of Gar-A on amelioration of lipotoxicity was measured by estimating the LDH levels. The doses for in vivo experiments were fixed by Irwin test, between 50 and 100 mg/kg concentrations, through oral route. The acute antihyperlipidemic effect of Gar-A was assessed in Triton WR-1339 induced hyperlipidemic animals. The chronic antihyperlipidemic and anti-NAFLD effects of Gar-A were evaluated in HFD fed rats. In vitro experiments with HepG2 cell line indicated that the cells treated with Gar-A did not show any significant reduction in the viability up to 70 µg/mL concentration. Steatotic HepG2 cells treated with Gar-A showed a significant reduction in lipid accumulation at 2.5-10 µg/mL concentrations. In triton induced hyperlipidemic rats, the treatment significantly reduced the lipid levels at the synthesis phase. The treatment with Gar-A to the HFD fed animals significantly lowered the steatosis and transaminase levels. The other biochemical parameters such as TC, TG, LDL-c, ALP and ACP were also decreased significantly. Treatment with Gar-A significantly lowered the hyperlipidemia and fat accumulation in the liver; detailed molecular investigations are necessary to establish the antihyperlipidemic and hepatoprotective potentials of Gar-A.
[Mh] Termos MeSH primário: Dieta Hiperlipídica
Flavonas/farmacologia
Hipolipemiantes/farmacologia
Fígado/efeitos dos fármacos
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Flavonas/química
Flavonas/uso terapêutico
Gardenia/química
Gardenia/metabolismo
Células Hep G2
Seres Humanos
Hiperlipidemias/induzido quimicamente
Hiperlipidemias/tratamento farmacológico
Hiperlipidemias/patologia
Hipolipemiantes/química
Hipolipemiantes/uso terapêutico
Lipídeos/sangue
Fígado/metabolismo
Masculino
Hepatopatia Gordurosa não Alcoólica/metabolismo
Hepatopatia Gordurosa não Alcoólica/patologia
Hepatopatia Gordurosa não Alcoólica/prevenção & controle
Ácido Oleico/toxicidade
Palmitatos/toxicidade
Polietilenoglicóis/toxicidade
Substâncias Protetoras/química
Substâncias Protetoras/uso terapêutico
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavones); 0 (Hypolipidemic Agents); 0 (Lipids); 0 (Palmitates); 0 (Protective Agents); 24J0W87Z43 (gardenin A); 2UMI9U37CP (Oleic Acid); 30IQX730WE (Polyethylene Glycols); Y27PUL9H56 (tyloxapol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


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[PMID]:28322405
[Au] Autor:Oliveira H; Cai X; Zhang Q; de Freitas V; Mateus N; He J; Fernandes I
[Ad] Endereço:REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal. iva.fernandes@fc.up.pt.
[Ti] Título:Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells.
[So] Source:Food Funct;8(4):1672-1679, 2017 Apr 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency. Additionally, and since after absorption crocins are metabolized into crocetin, the antiproliferative capacity of crocetin was assayed in MKN-28 (stomach), MCF-7 (breast) and Caco-2 (colon) cancer cell lines. The results point to an antiproliferative effect of crocetin on the three cell lines tested. Anti-inflammatory properties were also assayed. Overall, crocetin showed a potential involvement in the downregulation of IL-1ß and TNF-α but not IL-6. Altogether, these results suggest that these compounds can have an important role against cancer proliferation, highlighting the importance of Gardenia jasminoides Ellis as a nutraceutical food source.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacocinética
Carotenoides/farmacocinética
Proliferação Celular/efeitos dos fármacos
Gardenia/química
Absorção Gastrointestinal/efeitos dos fármacos
Extratos Vegetais/farmacocinética
[Mh] Termos MeSH secundário: Anti-Inflamatórios/farmacologia
Carotenoides/farmacologia
Linhagem Celular Tumoral
Frutas/química
Seres Humanos
Interleucina-6/genética
Interleucina-6/metabolismo
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Interleukin-6); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00091j


  8 / 302 MEDLINE  
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[PMID]:28275293
[Au] Autor:Li JY; Cao HY; Sun L; Sun RF; Wu C; Bian YQ; Dong S; Liu P; Sun MY
[Ad] Endereço:Jian-Yuan Li, Hong-Yan Cao, Run-Fei Sun, Chao Wu, Yan-Qin Bian, Shu Dong, Ping Liu, Ming-Yu Sun, Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
[Ti] Título:Therapeutic mechanism of Yin-Chén-Hao decoction in hepatic diseases.
[So] Source:World J Gastroenterol;23(7):1125-1138, 2017 Feb 21.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Yin-Chén-Hao decoction (YCHD) is a traditional Chinese medicine formula composed of capillaris ( ), gardenia ( ), and rhubarb ( ) that is used for the treatment of damp-heat jaundice. In modern clinics, YCHD is mostly used for hepatic diseases. This review summarizes the biological activities of YCHD and its medical applications. The main active compounds of YCHD are chlorogenic acid, rhein, geniposide, emodin, and scoparone. The pharmacological actions of YCHD include inhibition of hepatic steatosis, apoptosis, necrosis, anti-inflammation, and immune regulation. YCHD could be developed as a new therapeutic strategy for the treatment of hepatic diseases.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/uso terapêutico
Hepatopatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antraquinonas/química
Anti-Inflamatórios/uso terapêutico
Antivirais/uso terapêutico
Artemisia/química
Ascite/tratamento farmacológico
Ácido Clorogênico/química
Ensaios Clínicos como Assunto
Cumarínicos/química
Emodina/química
Fígado Gorduroso/tratamento farmacológico
Gardenia/química
Seres Humanos
Iridoides/química
Extratos Vegetais/uso terapêutico
Rheum/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Anti-Inflammatory Agents); 0 (Antiviral Agents); 0 (Coumarins); 0 (Drugs, Chinese Herbal); 0 (Iridoids); 0 (Plant Extracts); 0 (yin-chen-hao-tang); 145295QLXY (geniposide); 318ADP12RI (Chlorogenic Acid); H5841PDT4Y (scoparone); KA46RNI6HN (Emodin); YM64C2P6UX (rhein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v23.i7.1125


  9 / 302 MEDLINE  
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[PMID]:28264528
[Au] Autor:Zhang A; Chang D; Zhang Z; Li F; Li W; Wang X; Li Y; Hua Q
[Ad] Endereço:School of Basic Medical Science, Beijing University of Chinese Medicine, 11 East Road, North 3rd Ring Road, Chaoyang District, Beijing 100029, China. aozhezhang@outlook.com.
[Ti] Título:In Vitro Selection of DNA Aptamers that Binds Geniposide.
[So] Source:Molecules;22(3), 2017 Feb 28.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Geniposide is a key iridoid glycoside from Gardenia jasminoides fructus widely used in traditional Chinese herbal medicine. However, detection of this small molecule represents a significant challenge mostly due to the lack of specific molecular recognition elements. In this study, we have performed in vitro selection experiments to isolate DNA aptamers that can specifically bind geniposide. Using a stringent selection procedure, we have isolated DNA aptamers that can distinguish geniposide from genipin and glucose, two structural analogs of geniposide. Two top aptamers exhibit low micromolar binding affinity towards geniposide, but show significantly reduced affinity to genipin and glucose. These aptamers have the potential to be further developed into analytical tools for the detection of geniposide.
[Mh] Termos MeSH primário: Aptâmeros de Nucleotídeos/isolamento & purificação
Iridoides/metabolismo
Técnica de Seleção de Aptâmeros/métodos
[Mh] Termos MeSH secundário: Aptâmeros de Nucleotídeos/química
Aptâmeros de Nucleotídeos/metabolismo
Gardenia/química
Glucose/química
Iridoides/química
Iridoides/isolamento & purificação
Medicina Tradicional Chinesa
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aptamers, Nucleotide); 0 (Iridoids); 0 (Plant Extracts); 145295QLXY (geniposide); A3V2NE52YG (genipin); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


  10 / 302 MEDLINE  
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[PMID]:28130824
[Au] Autor:Zhang H; Feng N; Xu YT; Li TX; Gao XM; Zhu Y; Song YS; Wang YN; Wu HH
[Ad] Endereço:Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chemistry and Analysis of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 312 Anshan Xidao Road, Nankai District, Tianjin, 300193, P. R.
[Ti] Título:Chemical Constituents from the Flowers of Wild Gardenia jasminoides J.Ellis.
[So] Source:Chem Biodivers;14(5), 2017 May.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Four new iridoids, 2'-O-(E)-coumaroylshanzhiside (1), 6'-O-(E)-coumaroylshanzhiside (2), 8α-butylgardenoside B (3), 6α-methoxygenipin (4), and one new phenylpropanoid glucoside, 5-(3-hydroxypropyl)-2-methoxyphenyl ß-d-glucopyranoside (5), together with sixteen known compounds, were isolated from the edible flowers of wild Gardenia jasminoides J.Ellis. Their chemical structures were characterized by extensive spectroscopic techniques, including 1D- and 2D-NMR, HR-ESI-MS, and CD experiments. The absolute configurations of the new isolates' sugar moiety were assigned by HPLC analysis of the acid hydrolysates. Furthermore, the antioxidant activities of those isolates were preliminarily evaluated by DPPH scavenging experiment. And comparison of H-NMR spectra for the EtOH extract of G. jasminoides J.Ellis, gardenoside B and geniposide revealed that the flowers of this plant have a considerable content of gardenoside B instead of geniposide in the fruits, indicating different activities and applications in people's daily life.
[Mh] Termos MeSH primário: Gardenia/química
Extratos Vegetais/análise
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Flores/química
Frutas/química
Iridoides/isolamento & purificação
Estrutura Molecular
Extratos Vegetais/química
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Iridoids); 0 (Plant Extracts); 145295QLXY (geniposide); INE79XNR2C (gardenoside)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600437



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