Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.456.937.404 [Categoria DeCS]
Referências encontradas : 9 [refinar]
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[PMID]:27005511
[Au] Autor:Perez-Meseguer J; Delgado-Montemayor C; Ortíz-Torres T; Salazar-Aranda R; Cordero-Perez P; de Torres NW
[Ad] Endereço:Universidad Autónoma de Nuevo León, Departamento de Química Analítica, Facultad de Medicina. Av. Fancisco I. Madero y Dr Aguirre Pequeño S/N. Col Mitras Centro. CP 64460. Monterrey, NL. México.
[Ti] Título:Antioxidant and hepatoprotective activity of Hamelia patens extracts.
[So] Source:Pak J Pharm Sci;29(1 Suppl):343-8, 2016 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Hamelia patens is widely used in the traditional medicine of Mexico and Central America for the treatment of illnesses associated with inflammatory processes. In this study, antioxidant and hepatoprotective activity were assayed on the methanolic crude (ME), hexane (HE), ethyl acetate (AE), and butanol (BE) extracts of H. patens. The total phenolic content (TPC) as mg of gallic acid equivalents per g of dry extract was determined by Folin-Ciocalteu's method (ME=141.58±11.99, HE=33.96±1.13, AE=375.18±13.09, BE=132.08±3.62), and antioxidant activity by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) free radical-scavenging method (EC(50) ME=77.87±5.67, HE=236.64±26.32, AE=45.87±2.24, BE=50.97±0.85µg/mL). Hepatoprotective activity was evaluated through AST activity on HepG2 cells subjected to damage with CCl(4) (ME=62.5±3.41, HE=72.25±2.87, AE=63.50±4.20, BE=43.74±4.03). BE showed the greater hepatoprotective activity and a good antioxidant capacity, while HE did not show hepatoprotective or antioxidant activity. Cytotoxicity was evaluated on Vero cells cultures; none showed significant toxicity.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Hamelia/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Aspartato Aminotransferases/análise
Compostos de Bifenilo
Intoxicação por Tetracloreto de Carbono/patologia
Intoxicação por Tetracloreto de Carbono/prevenção & controle
Linhagem Celular
Cercopithecus aethiops
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Fenóis/análise
Picratos
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Polifenóis/química
Polifenóis/farmacologia
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 0 (Polyphenols); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 2.6.1.1 (Aspartate Aminotransferases)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE


  2 / 9 MEDLINE  
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[PMID]:26731099
[Au] Autor:Jiménez-Suárez V; Nieto-Camacho A; Jiménez-Estrada M; Alvarado Sánchez B
[Ad] Endereço:a Unidad Académica Multidisciplinaria Zona Huasteca, Universidad Autónoma de San Luis Potosí , S.L.P , México ;
[Ti] Título:Anti-inflammatory, free radical scavenging and alpha-glucosidase inhibitory activities of Hamelia patens and its chemical constituents.
[So] Source:Pharm Biol;54(9):1822-30, 2016 Sep.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Context Hamelia patens Jacq. (Rubiaceae) is traditionally used to treat wounds, inflammation and diabetes. However, there is still a lack of scientific evidence to support these applications. Objective The objective of this study is to evaluate the anti-inflammatory, antioxidant and antidiabetic activities of Hamelia patens, and identify its bioactive compounds. Materials and methods Four extracts were obtained by maceration and liquid-liquid extraction: HEX, DCM-EtOAc, MeOH-EtOAc and MeOH-Aq. The anti-inflammatory effect was evaluated orally on rat paw carrageenan-induced oedema over 6 h (50, 200 and 500 mg/kg), and topically in mouse ear oedema induced by 12-tetradecanoylphorbol-13-acetate (TPA) after 4 h (0.5 and 1 mg/ear). We also evaluated myeloperoxidase levels in ear tissue, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging ability, and in vitro α-glucosidase inhibition. The chemical compounds were separated by column chromatography and identified by spectroscopic analysis. Results We found that the oral administration of the HEX extract at 500 and 200 mg/kg significantly decreased the carrageenan-induced inflammation after 1 and 3 h, respectively. The MeOH-EtOAc extract significantly inhibited myeloperoxidase activity (83.5%), followed by the DCM-EtOAc extract (76%), ß-sitosterol/stigmasterol (72.7%) and the HEX extract (55%), which significantly decreased oedema induced by TPA at both doses, giving a similar effect to indomethacin. We also found that the MeOH-EtOAc, MeOH-Aq and DCM-EtOAc extracts showed good DPPH scavenging activity (IC50 values of 18.6, 93.9 and 158.2 µg/mL, respectively). The HEX extract showed the lowest α-glucosidase inhibition (an IC50 value of 26.07 µg/mL), followed by the MeOH-EtOAc extract (an IC50 value of 30.18 µg/mL), ß-sitosterol/stigmasterol (IC50 34.6 µg/mL) and compound A ((6E,10E,14E,18E)-2,6,10,14,18,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene, an IC50 value of 114.6 µg/mL), which were isolated for the first time from Hamelia patens. Discussion and conclusion Hamelia patens possesses anti-inflammatory, antioxidant and α-glucosidase inhibitory activities, which support its traditional use. These effects can be attributed to the identified compounds.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Edema/prevenção & controle
Depuradores de Radicais Livres/farmacologia
Inibidores de Glicosídeo Hidrolases/farmacologia
Hamelia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Compostos de Bifenilo/química
Carragenina
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Edema/induzido quimicamente
Edema/metabolismo
Feminino
Depuradores de Radicais Livres/isolamento & purificação
Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Hamelia/química
Peroxidase/metabolismo
Fitoterapia
Picratos/química
Folhas de Planta
Plantas Medicinais
Ratos Wistar
Proteínas de Saccharomyces cerevisiae/antagonistas & inibidores
Proteínas de Saccharomyces cerevisiae/metabolismo
Solventes/química
Acetato de Tetradecanoilforbol
Fatores de Tempo
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Glycoside Hydrolase Inhibitors); 0 (Picrates); 0 (Saccharomyces cerevisiae Proteins); 0 (Solvents); 9000-07-1 (Carrageenan); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.11.1.7 (Peroxidase); EC 3.2.1.20 (alpha-Glucosidases); NI40JAQ945 (Tetradecanoylphorbol Acetate)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160106
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1129544


  3 / 9 MEDLINE  
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[PMID]:25298204
[Au] Autor:Nethi SK; Mukherjee S; Veeriah V; Barui AK; Chatterjee S; Patra CR
[Ad] Endereço:Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad - 500007, India. crpatra@iict.res.in patra.chitta@gmail.com.
[Ti] Título:Bioconjugated gold nanoparticles accelerate the growth of new blood vessels through redox signaling.
[So] Source:Chem Commun (Camb);50(92):14367-70, 2014 Nov 28.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have designed and developed novel pro-angiogenic bio-synthesized gold nanoconjugates (b-Au-HP) that make new blood vessels, as observed by several in vitro and in vivo assays, suggesting their future potential applications in alternative treatment strategies for wound healing, cardiovascular diseases (CVD) and ischemic diseases using a nanomedicine approach.
[Mh] Termos MeSH primário: Ouro/farmacologia
Nanopartículas Metálicas
Nanoconjugados
Neovascularização Fisiológica/efeitos dos fármacos
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Embrião de Galinha
Cloretos/química
Células Endoteliais/efeitos dos fármacos
Células Endoteliais/fisiologia
Ouro/química
Compostos de Ouro/química
Química Verde
Hamelia
Seres Humanos
Nanopartículas Metálicas/química
Nanoconjugados/química
Oxirredução
Extratos Vegetais/química
Folhas de Planta
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chlorides); 0 (Gold Compounds); 0 (Nanoconjugates); 0 (Plant Extracts); 7440-57-5 (Gold); 8H372EGX3V (gold tetrachloride, acid)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:151123
[Lr] Data última revisão:
151123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141010
[St] Status:MEDLINE
[do] DOI:10.1039/c4cc06996j


  4 / 9 MEDLINE  
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Texto completo
[PMID]:24598826
[Au] Autor:Peters VE
[Ad] Endereço:Odum School of Ecology, University of Georgia, Athens, Georgia, United States of America.
[Ti] Título:Intercropping with shrub species that display a 'steady-state' flowering phenology as a strategy for biodiversity conservation in tropical agroecosystems.
[So] Source:PLoS One;9(3):e90510, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Animal species in the Neotropics have evolved under a lower spatiotemporal patchiness of food resources compared to the other tropical regions. Although plant species with a steady-state flowering/fruiting phenology are rare, they provide predictable food resources and therefore may play a pivotal role in animal community structure and diversity. I experimentally planted a supplemental patch of a shrub species with a steady-state flowering/fruiting phenology, Hamelia patens Jacq., into coffee agroforests to evaluate the contribution of this unique phenology to the structure and diversity of the flower-visiting community. After accounting for the higher abundance of captured animals in the coffee agroforests with the supplemental floral resources, species richness was 21% higher overall in the flower-visiting community in these agroforests compared to control agroforests. Coffee agroforests with the steady-state supplemental floral patch also had 31% more butterfly species, 29% more hummingbird species, 65% more wasps and 85% more bees than control coffee agroforests. The experimental treatment, together with elevation, explained 57% of the variation in community structure of the flower-visiting community. The identification of plant species that can support a high number of animal species, including important ecosystem service providers, is becoming increasingly important for restoration and conservation applications. Throughout the Neotropics plant species with a steady-state flowering/fruiting phenology can be found in all aseasonal forests and thus could be widely tested and suitable species used throughout the tropics to manage for biodiversity and potentially ecosystem services involving beneficial arthropods.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais
Flores/crescimento & desenvolvimento
Hamelia/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Agricultura
Animais
Abelhas
Biodiversidade
Aves
Borboletas
Coffea/crescimento & desenvolvimento
Costa Rica
Polinização
Crescimento Demográfico
Floresta Úmida
Estações do Ano
Vespas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1501
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140307
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0090510


  5 / 9 MEDLINE  
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[PMID]:23285803
[Au] Autor:Paniagua-Vega D; Cerda-García-Rojas CM; Ponce-Noyola T; Ramos-Valdivia AC
[Ad] Endereço:Departamento de Biotecnología y Bioingeniería, Centro de Investigación y de Estudios Avanzados del Instituto Nacional, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, 07360 Mexico D. F., Mexico.
[Ti] Título:A new monoterpenoid oxindole alkaloid from Hamelia patens micropropagated plantlets.
[So] Source:Nat Prod Commun;7(11):1441-4, 2012 Nov.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chemical studies on Hamelia patens (Rubiaceae) micropropagated plantlets allowed production of a new monoterpenoid oxindole alkaloid, named (-)-hameline (7), together with eight known alkaloids, tetrahydroalstonine (1), aricine (2), pteropodine (3), isopteropodine (4), uncarine F (5), speciophylline (6), palmirine (8), and rumberine (9). The structure of the new alkaloid was assigned on the basis of 1D and 2D NMR spectroscopy, mass spectrometry, and molecular modeling.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Hamelia/química
Monoterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides/química
Técnicas de Cultura
Estrutura Molecular
Monoterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Monoterpenes)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:130104
[Lr] Data última revisão:
130104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130105
[St] Status:MEDLINE


  6 / 9 MEDLINE  
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[PMID]:15467206
[Au] Autor:Reyes-Chilpa R; Rivera J; Oropeza M; Mendoza P; Amekraz B; Jankowski C; Campos M
[Ad] Endereço:Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior Ciudad Universitaria, DF México.
[Ti] Título:Methanol extracts of Hamelia patens containing oxindole alkaloids relax KCl-induced contraction in rat myometrium.
[So] Source:Biol Pharm Bull;27(10):1617-20, 2004 Oct.
[Is] ISSN:0918-6158
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Hamelia patens JAQC. (Rubiaceae) is a medicinal bush widely distributed in tropical areas of the American continent. It is used in Mexican Traditional Medicine for the treatment of menstrual disorders, therefore suggesting that its chemical constituents may have some effect on myometrium contractility. Physiological effects might differ due to quantitative variations in the content of alkaloids arising from its wide geographical distribution. To test this hypothesis, the content of oxindole alkaloids in methanol extracts of five different samples collected in Mexico was quantified by GC-MS. Each extract was assayed on contractility of estrogen-primed rat myometrium. Variations in the content of alkaloids were observed among the different samples. All samples relaxed in a concentration-dependent manner the high KCl-induced contraction in rat myometrium. Those which lack rumberine and/or maruquine displayed a higher relaxant effect than samples containing them, suggesting that these alkaloids might counteract the effects of isopteropodine. However, in contrast with verapamil, Hamelia patens metanol extracts are poor relaxants.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Hamelia
Miométrio/efeitos dos fármacos
Cloreto de Potássio/farmacologia
Contração Uterina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alcaloides/química
Animais
Relação Dose-Resposta a Droga
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Técnicas In Vitro
México
Miométrio/fisiologia
Extratos Vegetais
Plantas Medicinais
Ratos
Ratos Sprague-Dawley
Verapamil/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Plant Extracts); 660YQ98I10 (Potassium Chloride); CJ0O37KU29 (Verapamil)
[Em] Mês de entrada:0507
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041007
[St] Status:MEDLINE


  7 / 9 MEDLINE  
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[PMID]:15453149
[Ti] Título:[The fire bush (Hamelia) heats the bacteria].
[Ti] Título:Der Feuerbusch heizt Bakterien ein..
[So] Source:Praxis (Bern 1994);93(31-32):1264, 2004 Jul 28.
[Is] ISSN:1661-8157
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Mh] Termos MeSH primário: Infecções Bacterianas/tratamento farmacológico
Hamelia
Medicina Tradicional
Fitoterapia
Doenças Reumáticas/tratamento farmacológico
Ferimentos e Lesões/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Masculino
Extratos Vegetais/uso terapêutico
Pesquisa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:0410
[Cu] Atualização por classe:080610
[Lr] Data última revisão:
080610
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040930
[St] Status:MEDLINE


  8 / 9 MEDLINE  
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[PMID]:12963138
[Au] Autor:Gomez-Beloz A; Rucinski JC; Balick MJ; Tipton C
[Ad] Endereço:Biology Department, Saint Martin's College, 5300 Pacific Avenue SE, Lacey, WA 98503, USA. agomezbeloz@stmartin.edu
[Ti] Título:Double incision wound healing bioassay using Hamelia patens from El Salvador.
[So] Source:J Ethnopharmacol;88(2-3):169-73, 2003 Oct.
[Is] ISSN:0378-8741
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Hamelia patens Jacq. (Rubiaceae) has received little attention in the laboratory for its wound healing ability even though it is commonly used as a treatment for wounds throughout Central America. A double incision wound healing bioassay was carried out with a crude extract of Hamelia patens collected from El Salvador. Animals were divided into three groups. Group I (n = 14) had the left incision treated with 5% (w/w) Hamelia patens and the contralateral side with petroleum jelly (PJ). Group II (n = 14) had the left incision treated with 10% (w/w) ointment and the contralateral side with petroleum jelly. Group III (n = 10) had the left incision treated with petroleum jelly and the contralateral side left untreated. Breaking strength of the incisions was measured on day 7 and day 12. For Groups I and II, there was no significant difference between treatment and control incisions at day 7. On day 12, there was a significant difference between the treated and control incisions for Groups I and II. There was no significant difference between petroleum jelly and untreated incisions for Group III on day 7 and day 12. Hamelia patens does increase breaking strength of wounds significantly more than the control group. Further wound healing studies of this plant are warranted.
[Mh] Termos MeSH primário: Hamelia/química
Medicina Tradicional
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
El Salvador
Masculino
Extratos Vegetais/farmacologia
Ratos
Ratos Sprague-Dawley
Pele/efeitos dos fármacos
Pele/lesões
Fenômenos Fisiológicos da Pele
Resistência à Tração/efeitos dos fármacos
Resistência à Tração/fisiologia
Ferimentos Penetrantes/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:0403
[Cu] Atualização por classe:081121
[Lr] Data última revisão:
081121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030910
[St] Status:MEDLINE


  9 / 9 MEDLINE  
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[PMID]:12787962
[Au] Autor:Camporese A; Balick MJ; Arvigo R; Esposito RG; Morsellino N; De Simone F; Tubaro A
[Ad] Endereço:Clinical Microbiology and Antibiotic Therapy Unit, S. Maria degli Angeli General Hospital, Via Montereale 24, 33170, Pordenone, Italy.
[Ti] Título:Screening of anti-bacterial activity of medicinal plants from Belize (Central America).
[So] Source:J Ethnopharmacol;87(1):103-7, 2003 Jul.
[Is] ISSN:0378-8741
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Twenty-one extracts from seven herbal drugs, Aristolochia trilobata (Aristolochiaceae) leaves and bark, Bursera simaruba (Burseraceae) bark, Guazuma ulmifolia (Sterculiaceae) bark, Hamelia patens (Rubiaceae) leaves and Syngonium podophyllum (Araceae) leaves and bark, used in traditional medicine of Belize (Central America) as deep and superficial wound healers, were evaluated for their anti-bacterial properties. Activity was tested against standard strains of Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212. Almost all the extracts were able to inhibit the growth of one or more of the bacterial strains, except that of Enterococcus faecalis. For the first time an anti-microbial activity is reported for Aristolochia trilobata as well as for Syngonium podophyllum. The hexane extracts of Aristolochia trilobata leaves and bark were the most active extracts against Staphylococcus aureus (MIC=0.31 and 0.625mg/ml, respectively).
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Aristolochia/química
Bursera/química
Hamelia/química
Sterculiaceae/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Belize
Enterococcus faecalis/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Seres Humanos
Testes de Sensibilidade Microbiana
Casca de Planta/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:0311
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030606
[St] Status:MEDLINE



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