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Pesquisa : B01.650.940.800.575.912.250.456.937.566 [Categoria DeCS]
Referências encontradas : 360 [refinar]
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[PMID]:29374471
[Au] Autor:Abu N; Zamberi NR; Yeap SK; Nordin N; Mohamad NE; Romli MF; Rasol NE; Subramani T; Ismail NH; Alitheen NB
[Ad] Endereço:UKM Molecular Biology Institute (UMBI), UKM Medical Center, Jalan Yaacob Latif, Bandar Tun Razak 56000 Cheras, Kuala Lumpur, Malaysia.
[Ti] Título:Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L.
[So] Source:BMC Complement Altern Med;18(1):31, 2018 Jan 27.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Morinda citrifolia L. that was reported with immunomodulating and cytotoxic effects has been traditionally used to treat multiple illnesses including cancer. An anthraquinone derived from fruits of Morinda citrifolia L., nordamnacanthal, is a promising agent possessing several in vitro biological activities. However, the in vivo anti-tumor effects and the safety profile of nordamnacanthal are yet to be evaluated. METHODS: In vitro cytotoxicity of nordamnacanthal was tested using MTT, cell cycle and Annexin V/PI assays on human MCF-7 and MDA-MB231 breast cancer cells. Mice were orally fed with nordamnacanthal daily for 28 days for oral subchronic toxicity study. Then, the in vivo anti-tumor effect was evaluated on 4T1 murine cancer cells-challenged mice. Changes of tumor size and immune parameters were evaluated on the untreated and nordamnacanthal treated mice. RESULTS: Nordamnacanthal was found to possess cytotoxic effects on MDA-MB231, MCF-7 and 4T1 cells in vitro. Moreover, based on the cell cycle and Annexin V results, nordamnacanthal managed to induce cell death in both MDA-MB231 and MCF-7 cells. Additionally, no mortality, signs of toxicity and changes of serum liver profile were observed in nordamnacanthal treated mice in the subchronic toxicity study. Furthermore, 50 mg/kg body weight of nordamncanthal successfully delayed the progression of 4T1 tumors in Balb/C mice after 28 days of treatment. Treatment with nordamnacanthal was also able to increase tumor immunity as evidenced by the immunophenotyping of the spleen and YAC-1 cytotoxicity assays. CONCLUSION: Nordamnacanthal managed to inhibit the growth and induce cell death in MDA-MB231 and MCF-7 cell lines in vitro and cease the tumor progression of 4T1 cells in vivo. Overall, nordamnacanthal holds interesting anti-cancer properties that can be further explored.
[Mh] Termos MeSH primário: Aldeídos/farmacologia
Antraquinonas/farmacologia
Antineoplásicos/farmacologia
Neoplasias da Mama/metabolismo
Fatores Imunológicos/farmacologia
Morinda/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Aldeídos/química
Aldeídos/toxicidade
Animais
Antraquinonas/química
Antraquinonas/toxicidade
Antineoplásicos/química
Antineoplásicos/toxicidade
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Feminino
Seres Humanos
Fatores Imunológicos/química
Fatores Imunológicos/toxicidade
Células MCF-7
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Testes de Toxicidade Subcrônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aldehydes); 0 (Anthraquinones); 0 (Antineoplastic Agents); 0 (Immunologic Factors); 0 (Plant Extracts); 0 (nordamnacanthal)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2102-3


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[PMID]:28524250
[Au] Autor:Torres MAO; de Fátima Braga Magalhães I; Mondêgo-Oliveira R; de Sá JC; Rocha AL; Abreu-Silva AL
[Ad] Endereço:Rede Nordeste de Biotecnologia-RENORBIO, Ponto focal Maranhão, São Luís, Brazil.
[Ti] Título:One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia.
[So] Source:Phytother Res;31(7):971-979, 2017 Jul.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Morinda citrifolia, also known as noni, is commonly used in popular medicine in Brazil. Many parts of the noni tree are utilized in such practices, including the roots, leaves and seeds. Through a search of online databases, the present article reviews 92 research studies on the biological actions of M. citrifolia. The paper will discuss the therapeutic effects of noni and its compounds in a variety of forms of presentation, focusing on studies that support its traditional use. A large and diverse number of properties were identified, which were divided into immunostimulatory, antitumor, antidiabetic, anti-obesity, antibacterial and anti-septic, antifungal, antiviral, leishmanicidal, antiinflammatory, antinociceptive and analgesic, antioxidant, neuroprotective, wound healing, antiallergic, antiangiogenic, antiemetic and anti-nausea, anti-gastric ulcer and oesophagitis, anthelmintic, antimutagenic, antipsychotic, anxiolytic, photoprotective, anti-wrinkle and periodontal tissue regeneration activities. While it was concluded that although M. citrifolia is widely and successfully used for the treatment or prevention of various diseases, it should be consumed carefully, and only after exhaustive studies into its chemical constituents and mechanisms of action, both in in vitro and in vivo models, as well as clinical trials. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Morinda/química
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Brasil
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5817


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[PMID]:28501689
[Au] Autor:M S; K B; M B; S J; S A; A S; P N; R S
[Ad] Endereço:Advanced Green Chemistry Lab, Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi 600 003, Tamil Nadu, India. Electronic address: drmsgreenchemistrylab@gmail.com.
[Ti] Título:Obtaining titanium dioxide nanoparticles with spherical shape and antimicrobial properties using M. citrifolia leaves extract by hydrothermal method.
[So] Source:J Photochem Photobiol B;171:117-124, 2017 Jun.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this work, we synthesized titanium dioxide (TiO ) nanoparticles using leaf extract of Morinda citrifolia (M. citrifolia) by the advanced hydrothermal method. The synthesized TiO nanoparticles were characterized by X-ray diffraction (XRD), Fourier transmission infrared (FT-IR), Ultraviolet-visible diffuse reflectance (UV-Vis DRS), Ultraviolet-visible spectroscopy (UV-Vis), Raman spectroscopy, and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM with EDX) techniques. The XRD major peak at 27.3° corresponds to the (110) lattice plane of tetragonal rutile TiO phase and average crystalline size of nanoparticles is 10nm. The FT-IR result confirmed that TiO nanoparticles and the presences of very few amount of anthraquinone and phenolic compounds of the leaf extract. The obtained nanoparticles were also characterized by UV-Vis DRS absorption spectroscopy and an intense band at 423nm clearly reveals the formation of nanoparticles. SEM images with EDX spectra clearly reveal the size of the nanoparticles, between 15 and 19nm in excellent quasi-spherical shape, by virtue of stabilization (capping) agent. The presence of elements-titanium and oxygen was verified with EDX spectrum. Furthermore, the inhibitory activity of green synthesized TiO nanoparticles was tested against human pathogens like Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger by the agar well-diffusion method. The TiO nanoparticles exhibited superior antimicrobial activity against Gram-positive bacteria, demonstrating their antimicrobial value against pathogenic diseases.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Morinda/química
Titânio/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/síntese química
Anti-Infecciosos/química
Fungos/efeitos dos fármacos
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Química Verde
Nanopartículas Metálicas/química
Nanopartículas Metálicas/toxicidade
Nanopartículas Metálicas/ultraestrutura
Microscopia Eletrônica de Varredura
Morinda/metabolismo
Tamanho da Partícula
Extratos Vegetais/química
Folhas de Planta/química
Folhas de Planta/metabolismo
Espectrometria por Raios X
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE


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[PMID]:28480424
[Au] Autor:O ET; Halimah A H
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Nigeria.
[Ti] Título:COGNITIVE-ENHANCING PROPERTIES OF (RUBIACEAE) AND (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE.
[So] Source:Afr J Tradit Complement Altern Med;14(3):136-141, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of (L) Rubiaceae and (DC) ex. K Heyne in scopolamine induced amnesic animals. MATERIALS AND METHODS: The anti-amnesic activity of the ethyl acetate extracts of and at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg were assessed in scopolamine induced amnesic mice using Morris water maze test model. Effect of the extracts on the histology of the hippocampus was also evaluated. RESULTS: The ethyl acetate extract of and ameliorated scopolamine induced memory deficit in the animals under study. There was no effect of the extract on the histology of the hippocampus. However, there was an increase in the density of cells in the hippocampus of treated group as compared to the untreated. CONCLUSION: and showed considerable enhancement of cognition in scopolamine induced amnesic mice.
[Mh] Termos MeSH primário: Amnésia/tratamento farmacológico
Fabaceae/química
Morinda/química
Nootrópicos/farmacologia
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Amnésia/induzido quimicamente
Amnésia/patologia
Animais
Cognição/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Hipocampo/patologia
Aprendizagem em Labirinto/efeitos dos fármacos
Camundongos
Hidrobrometo de Escopolamina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nootropic Agents); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i3.14


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[PMID]:28359947
[Au] Autor:Marisa Halim A; Lee PP; Chang ZW; Chang CC
[Ad] Endereço:Department of Aquaculture, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan, ROC; Faculty of Fisheries and Marine Science, University of Brawijaya, Malang, East Java 65145, Indonesia.
[Ti] Título:The hot-water extract of leaves of noni, Morinda citrifolia, promotes the immunocompetence of giant freshwater prawn, Macrobrachium rosenbergii.
[So] Source:Fish Shellfish Immunol;64:457-468, 2017 May.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The hot-water Morinda citrifolia leaf extract (HMLE) was prepared for in vitro assessment on phenoloxidase (PO) activity, respiratory bursts (RBs), and phagocytic activity (PA). Furthermore, the HMLE was administrated in the diet at 0.6, 3, and 6 g (kg diet) for Macrobrachium rosenbergii, and the potential effects on the immunocompetence of prawns were evaluated. PO activity, RBs, and PA in hemocytes incubated with the HMLE at 140, 20, 20, and 140 mg l significantly increased. The immune parameters of the total hemocyte count (THC), differential hemocyte count (DHC), RBs, PO activity, superoxide dismutase (SOD) activity, PA, transglutaminase (TG) activity and hemolymph clotting time were evaluated before and after 1, 3, 5, 7, and 9 weeks of the feeding trial. During 9 weeks of the feeding trial, higher THCs, DHCs, RBs, PO, and TG as well as accelerated clotting times were observed in prawns fed HMLE-containing diets at 0.6 g kg . The mRNA expressions of prophenoloxidase, TG, crustin, and lysozyme of prawns fed HMLE-containing diets at 0.6 g kg for 9 weeks of the feeding trial significantly increased. The susceptibility of prawns fed the HMLE at 0.6 g kg to Lactococcus garvieae infection significantly decreased, and the relative survival percentage was 23.1%. We therefore found that HMLE administrated through the diet at 0.6 g kg was capable of enhancing the immunity and resistance against L. garvieae in M. rosenbergii.
[Mh] Termos MeSH primário: Imunocompetência
Lactococcus/fisiologia
Morinda/química
Palaemonidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Expressão Gênica/efeitos dos fármacos
Palaemonidae/genética
Palaemonidae/imunologia
Palaemonidae/microbiologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


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[PMID]:28268174
[Au] Autor:Lin YL; Lin HW; Chen YC; Yang DJ; Li CC; Chang YY
[Ad] Endereço:Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
[Ti] Título:Hepatoprotective effects of naturally fermented noni juice against thioacetamide-induced liver fibrosis in rats.
[So] Source:J Chin Med Assoc;80(4):212-221, 2017 Apr.
[Is] ISSN:1728-7731
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Excessive reactive oxygen species (ROS) can result in inflammation and cytokine secretion in the liver, and then activate hepatic stellate cells that cause the accumulation of extracellular matrix proteins, especially collagen, in liver tissue. Naturally fermented noni juice (NJ; Morinda citrifolia) has been used for decades as a nutraceutical in humans. In this study, we intended to examine if NJ can ameliorate ROS-induced liver fibrosis via a thioacetamide (TAA)-induced rat model. METHODS: The 50 rats used in this study were separated into five groups of 10 rats each for 8 weeks as follows: (1) control group; (2) TAA; (3) TAA+low-dose NJ (2.51 mL NJ/kg); (4) TAA+medium-dose NJ (5.02 mL NJ/kg); and (5) TAA+high-dose NJ (7.52 mL NJ/kg). RESULTS: Treatment with TAA resulted in lower body weight and serum lipid levels (p<0.05), while liver weight and collagen contents, and serum alanine aminotransferase and aspartate aminotransferase values were increased (p<0.05). The protective effects of NJ on TAA treatment resulted from decreased endoplasmic reticulum stress-related gene expressions (p<0.05), inflammatory cytokines, collagen accumulation, and matrix metalloproteinase (MMP-2 and MMP-9) activities, as well as upregulated (p<0.05) tissue inhibitors of metalloproteinase (TIMP-1 and TIMP-3) in livers. NJ also increased hepatic antioxidant capacities (p<0.05). CONCLUSION: Naturally fermented NJ manifests a protective potential on liver fibrosis via the enhancement of antioxidant capacities, as well as decreasing endoplasmic-reticulum stress and MMP-2/MMP-9 activities.
[Mh] Termos MeSH primário: Cirrose Hepática Experimental/tratamento farmacológico
Fígado/efeitos dos fármacos
Morinda
[Mh] Termos MeSH secundário: Animais
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Fermentação
Fígado/metabolismo
Masculino
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Substâncias Protetoras/farmacologia
Ratos
Ratos Wistar
Tioacetamida/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protective Agents); 075T165X8M (Thioacetamide); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28259164
[Au] Autor:Ishibashi Y; Matsui T; Isami F; Abe Y; Sakaguchi T; Higashimoto Y; Yamagishi SI
[Ad] Endereço:Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, 830-0011, Japan.
[Ti] Título:N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGE)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties.
[So] Source:BMC Complement Altern Med;17(1):137, 2017 Mar 04.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Advanced glycation end products (AGEs), senescent macroprotein derivatives formed during a normal aging process and acceleratedly under diabetic conditions, play a role in atherosclerotic cardiovascular disease. AGEs cause endothelial cell (EC) damage, an initial trigger for atherosclerosis through the interaction with a receptor for AGEs (RAGE). We have previously shown that n-butanol extracts of Morinda citrifolia (noni), a plant belonging to the family Rubiaceae, block the binding of AGEs to RAGE in vitro. In this study, we examined the effects of n-butanol extracts of noni on reactive oxygen species (ROS) generation and inflammatory reactions on AGE-exposed human umbilical vein ECs (HUVECs). METHODS: HUVECs were treated with 100 µg/ml AGE-bovine serum albumin (AGE-BSA) or non-glycated BSA in the presence or absence of 670 ng/ml n-butanol extracts of noni for 4 h. Then ROS generation and inflammatory and gene expression in HUVECs were evaluated by dihydroethidium staining and real-time reverse transcription-polymerase chain reaction analyses, respectively. THP-1 cell adhesion to HUVECs was measured after 2-day incubation of AGE-BSA or BSA in the presence or absence of 670 ng/ml n-butanol extracts of noni. RESULTS: N-butanol extracts of noni at 670 ng/ml significantly inhibited the AGE-induced ROS generation and RAGE, intercellular adhesion molecule-1 and plasminogen activator inhibitor-1 gene expressions in HUVECs. AGEs significantly increased monocytic THP-1 cell adhesion to HUVECs, which was also prevented by 670 ng/ml n-butanol extracts of noni. CONCLUSIONS: The present study demonstrated for the first time that N-butanol extracts of noni could suppress the AGE-induced inflammatory reactions in HUVECs through its anti-oxidative properties via blocking of the interaction of AGEs with RAGE. Inhibition of the AGE-RAGE axis by n-butanol extracts of noni may be a novel nutraceutical strategy for the treatment of cardiovascular disease.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Células Endoteliais/efeitos dos fármacos
Produtos Finais de Glicação Avançada/metabolismo
Morinda/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: 1-Butanol/química
Antioxidantes/química
Linhagem Celular Tumoral
Células Endoteliais da Veia Umbilical Humana
Seres Humanos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Glycation End Products, Advanced); 0 (Plant Extracts); 8PJ61P6TS3 (1-Butanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1641-3


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[PMID]:28252174
[Au] Autor:Bordallo PN; Monteiro AM; Sousa JA; Aragão FA
[Ad] Endereço:Embrapa Agroindústria Tropical, Fortaleza, CE, Brasil patricia.bordallo@embrapa.br.
[Ti] Título:Molecular marker-based genetic diversity analysis of scantly studied Brazilian accessions of a medicinal plant, Morinda citrifolia L. (noni).
[So] Source:Genet Mol Res;16(1), 2017 Feb 23.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Morinda citrifolia L., commonly known as noni, has been used for the treatment of various diseases for over two centuries. It was introduced and widely disseminated in Brazil because of its high market value and ease of adaptation to the soil and climatic conditions of the country. The aim of this study was to estimate the genetic variability of noni accessions from the collection of Embrapa Agroindústria Tropical in Brazil. We evaluated 36 plants of the 13 accessions of noni from the germplasm collection of M. citrifolia. Several methods of DNA extraction were tested. After definition of the method, the DNA of each sample was subjected to polymerase chain reactions using 20 random amplified polymorphic DNA primers. The band patterns on agarose gel were converted into a binary data matrix, which was used to estimate the genetic distances between the plants and to perform the cluster analyses. Of the total number of markers used in this study, 125 (81.1%) were polymorphic. The genetic distances between the genotypes ranged from 0.04 to 0.49. Regardless of the high number of polymorphic bands, the genetic variability of the noni plants evaluated was low since most of the genotypes belonged to the same cluster as shown by the dendrogram and Tocher's cluster analysis. The low genetic diversity among the studied noni individuals indicates that additional variability should be introduced in the germplasm collection of noni by gathering new individuals and/or by hybridizing contrasting individuals.
[Mh] Termos MeSH primário: Marcadores Genéticos/genética
Variação Genética
Morinda/genética
Plantas Medicinais/genética
Técnica de Amplificação ao Acaso de DNA Polimórfico/métodos
[Mh] Termos MeSH secundário: Brasil
Análise por Conglomerados
Primers do DNA/genética
DNA de Plantas/análise
DNA de Plantas/genética
Genótipo
Morinda/classificação
Filogenia
Plantas Medicinais/classificação
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers); 0 (DNA, Plant); 0 (Genetic Markers)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16019531


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[PMID]:28194046
[Au] Autor:Coutinho de Sousa B; Reis Machado J; da Silva MV; da Costa TA; Lazo-Chica JE; Degasperi TD; Rodrigues Junior V; Sales-Campos H; Uber Bucek E; Freire Oliveira CJ
[Ad] Endereço:Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.
[Ti] Título: (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis.
[So] Source:Mediators Inflamm;2017:6567432, 2017.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF- and IFN- , was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Colite/induzido quimicamente
Colite/tratamento farmacológico
Sulfato de Dextrana/toxicidade
Sucos de Frutas e Vegetais
Inflamação/tratamento farmacológico
Mucosa Intestinal/efeitos dos fármacos
Morinda/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Inflamação/metabolismo
Mucosa Intestinal/patologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 9042-14-2 (Dextran Sulfate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1155/2017/6567432


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[PMID]:28153468
[Au] Autor:Chithambo B; Noundou XS; Krause RW
[Ad] Endereço:Department of Chemistry, Rhodes University, PO Box 94, Grahamstown 6140, South Africa. Electronic address: bchithambo@yahoo.com.
[Ti] Título:Anti-malarial synergy of secondary metabolites from Morinda lucida Benth.
[So] Source:J Ethnopharmacol;199:91-96, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The roots, stem and leaves of Morinda lucida are used in some African countries as treatment against different types of fevers including yellow fever, malaria, trypanosomiasis and feverish conditions during child birth. AIM OF THE STUDY: To determine the in vitro cell toxicity and anti-malarial activity of the extracts of stem bark of M. lucida and to identify the secondary metabolites in the extract that may be responsible for this activity. MATERIALS AND METHODS: The cell toxicity studies of crude extract [dichloromethane (DCM): Methanol (MeOH) in a ratio of1:1 (v/v)] as well as compounds isolated from the same extract were carried out using human cervix adenocarcinoma cells (HeLa cells); while the anti-malarial activities of the same samples were performed against Plasmodium falciparum strain 3D7 using the parasite lactate dehydrogenase (pLDH) assay. The isolation of the active compounds was carried out using chromatographic techniques (column and thin layer chromatography) where as mass spectrometry (MS), Fourier transform infrared spectroscopy (FTIR) as well as 1D- and 2D- nuclear magnetic resonance (NMR) analyses were employed in the characterisation and identification of the isolated secondary metabolites. RESULTS: The pLDH and cell toxicity assays for the crude extract and the fractions of M. lucida indicated that some fractions reduced the malaria parasite viability by approximately 50% at 100µg/mL and they were not significantly cytotoxic. An IC done on the crude extract gave a value of 25µg/mL. The % cell viability for the crude extract in cell toxicity assay remained at 100%. Seven chemical constituents i.e. asperuloside (1), asperulosidic acid (2), stigmasterol (3a), ß-sitosterol (3b), cycloartenol (3c), campesterol (3d) and 5,15-O-dimethylmorindol (4) were isolated from the DCM-MeOH extract of stem bark. The isolated compounds tested were not that active by themselves individually at 20µM but their activities were increased when the isolated compounds were combined. As seen when compounds 2, 3 and 4 (% viability: 93, 123 and 101 respectively) were combined yielding an IC value of 17µM. Furthermore, this is the first report of compounds 1, 2, 3c, 3d and 4 isolated from M. lucida. CONCLUSION: The crude extract completely suppressed the growth of P. falciparum. This indicates that the crude extract contains many compounds that might be acting in synergy. The observed activity of the crude extract and the samples containing a mixture of different compounds support the traditional use of M. lucida for the treatment of malaria.
[Mh] Termos MeSH primário: Antimaláricos/metabolismo
Antimaláricos/farmacologia
Morinda
Extratos Vegetais/metabolismo
Extratos Vegetais/farmacologia
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antimaláricos/isolamento & purificação
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Seres Humanos
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Caules de Planta
Plasmodium falciparum/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE



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