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[PMID]:29247027
[Au] Autor:Abdusalam A; Tan D; Chang SM
[Ad] Endereço:Xinjiang Key Laboratory of Grassland Resources and Ecology and Ministry of Education Key Laboratory for Western Arid Region Grassland Resources and Ecology, College of Grassland and Environment Sciences, Xinjiang Agricultural University, Ürümqi 830052, PR China.
[Ti] Título:Sexual expression and reproductive output in the ephemeral are correlated with environmental conditions.
[So] Source:Am J Bot;104(12):1920-1929, 2017 Dec.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Abiotic environmental factors are often considered to be important in the distribution and maintenance of variation in sexual systems in flowering plants. Associations between sexes and abiotic factors are well documented in dioecious systems, but much less is known about this relationship in other sexually polymorphic systems. Species that are highly variable in sexual expression and habitat distribution can provide insights into the role of abiotic factors in maintaining variation in sexual expression. METHODS: Focusing on a sexually polymorphic species, , we measured sexual expression at both the flower and the plant level and examined vegetative and floral traits, pollen deposition, and reproductive success. We also tested for correlations between sexual expression and other traits and examined whether and how these traits covaried with abiotic environmental conditions. KEY RESULTS: We identified unique variation of sexual expression in . . There are four sexual morphs that display different combinations of the three flower types (pistillate, staminate, and perfect). Sexual morphs that are phenotypically more female (i.e., female and gynomonoecious morphs) are found in wetter and milder environments, and flower earlier than morphs that are more male (i.e., hermaphroditic and andromonoecious morphs). Additionally, floral organ size and reproductive success are influenced not only by the flower type but also by the sexual morph of the plant. CONCLUSIONS: Environmental conditions are likely to cause some of the variation in sexual expression found in . . Both genetic and ecological factors likely contribute to the maintenance of sexual variation in this species.
[Mh] Termos MeSH primário: Flores/anatomia & histologia
Geranium/fisiologia
Sementes/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Flores/fisiologia
Polinização
Reprodução/fisiologia
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1700258


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[PMID]:28552970
[Au] Autor:Wondimu T; Gizaw A; Tusiime FM; Masao CA; Abdi AA; Hou Y; Nemomissa S; Brochmann C
[Ad] Endereço:Department of Plant Biology & Biodiversity Management, College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
[Ti] Título:Genetic structuring, dispersal and taxonomy of the high-alpine populations of the Geranium arabicum/kilimandscharicum complex in tropical eastern Africa.
[So] Source:PLoS One;12(5):e0178208, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The scattered eastern African high mountains harbor a renowned and highly endemic flora, but the taxonomy and phylogeographic history of many plant groups are still insufficiently known. The high-alpine populations of the Geranium arabicum/kilimandscharicum complex present intricate morphological variation and have recently been suggested to comprise two new endemic taxa. Here we aim to contribute to a clarification of the taxonomy of these populations by analyzing genetic (AFLP) variation in range-wide high-alpine samples, and we address whether hybridization has contributed to taxonomic problems. We identified only two genetic groups. One corresponded to G. kilimandscharicum, which has been reported as exclusively high-alpine and confined to the eastern Rift mountains in East Africa. The other corresponded to G. arabicum, reported from lower altitudes on the same mountains as well as from a wide altitudinal span in Ethiopia and on the western Rift mountains in East Africa. The four populations analyzed of a recently described species from the Bale Mts in Ethiopia were admixed, indicating that they result from recent long-distance dispersal of G. kilimandscharicum from East Africa followed by hybridization with local G. arabicum in naturally disturbed habitats. Some admixture between the two genetic groups was also inferred on other mountains, supporting earlier suggestions of introgression based on morphology. We did not find support for recognition of the recently suggested new subspecies of G. arabicum in Ethiopia. Interestingly, the high-alpine G. kilimandscharicum lacked clear geographic structuring, suggesting a recent history of colonization of the different mountains or extensive intermountain gene flow.
[Mh] Termos MeSH primário: Altitude
Geranium/genética
Clima Tropical
[Mh] Termos MeSH secundário: África Oriental
Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Genes de Plantas
Geranium/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178208


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[PMID]:28525277
[Au] Autor:Tuominen A; Salminen JP
[Ad] Endereço:Laboratory of Organic Chemistry and Chemical Biology, Department of Chemistry, University of Turku , FI-20500 Turku, Finland.
[Ti] Título:Hydrolyzable Tannins, Flavonol Glycosides, and Phenolic Acids Show Seasonal and Ontogenic Variation in Geranium sylvaticum.
[So] Source:J Agric Food Chem;65(31):6387-6403, 2017 Aug 09.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The seasonal variation of polyphenols in the aboveground organs and roots of Geranium sylvaticum in four populations was studied using UPLC-DAD-ESI-QqQ-MS/MS. The content of the main compound, geraniin, was highest (16% of dry weight) in the basal leaves after the flowering period but stayed rather constant throughout the growing season. Compound-specific mass spectrometric methods revealed the different seasonal patterns in minor polyphenols. Maximum contents of galloylglucoses and flavonol glycosides were detected in the small leaves in May, whereas the contents of further modified ellagitannins, such as ascorgeraniin and chebulagic acid, increased during the growing season. In flower organs, the polyphenol contents differed significantly between ontogenic phases so that maximum amounts were typically found in the bud phase, except in pistils the amount of gallotannins increased significantly in the fruit phase. These results can be used in evaluating the role of polyphenols in plant-herbivore interactions or in planning the best collection times of G. sylvaticum for compound isolation purposes.
[Mh] Termos MeSH primário: Flavonoides/análise
Geranium/química
Glicosídeos/análise
Taninos Hidrolisáveis/análise
Hidroxibenzoatos/análise
Extratos Vegetais/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Folhas de Planta/química
Estações do Ano
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Glycosides); 0 (Hydrolyzable Tannins); 0 (Hydroxybenzoates); 0 (Plant Extracts); 29656-58-4 (phenolic acid); ZTG9LSS5QH (3-hydroxyflavone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00918


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[PMID]:28288945
[Au] Autor:Marcussen T; Meseguer AS
[Ad] Endereço:Monrads gate 21a, 0564 Oslo, Norway. Electronic address: thmsmrcssn@gmail.com.
[Ti] Título:Species-level phylogeny, fruit evolution and diversification history of Geranium (Geraniaceae).
[So] Source:Mol Phylogenet Evol;110:134-149, 2017 May.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The cosmopolitan genus Geranium L. (Geraniaceae) consists of c. 350 species distributed in temperate habitats worldwide, with most of its diversity concentrated in the Mediterranean region. Unlike other genera in Geraniaceae, the species of Geranium present contrasting seed discharge syndromes, i.e. the 'Erodium-type' (ET), the 'carpel-projection type' (CP), the 'seed-ejection type' (SE), and the 'inoperative type' (IT), which have been used to delimit major groups within the genus. However, phylogenetic relationships within Geranium are unknown and so is the evolution of the different seed discharge mechanisms. Here, we used a calibrated multispecies coalescent approach to infer the species-level phylogeny and divergence times of the genus based on chloroplast (rbcL, trnL-trnF) and nuclear (ITS) DNA sequences. Our sampling represents most of the morphological variation described in the genus. We reconstruct the evolution of the seed discharge mechanism using ancestral state reconstruction (ASR) techniques on the multispecies coalescent tree, and assess the association between fruit type evolution and species diversification using stochastic birth-death and trait-dependent diversification models. Finally, we reconstruct the early biogeographic history of the genus using discrete and continuous biogeographic analyses of species distribution centroids, including fossil evidence and tip dates. Our results show that fruit type is homoplasious and that the classification based on fruit type in Geranium is artificial. The taxonomy and putative apomorphic characters for Geranium are discussed. ASR of the fruit characters suggests that ET may represent the ancestral state in Geranium and from which CP originated twice, IT presumably once, and SE twice. The independent appearance of the SE syndrome is in both cases associated with increases in diversification rates in the genus. The biogeographic analysis centers the origin and early 10Ma diversification of Geranium on the Mediterranean region. The evolution of seed discharge mechanism about 5Ma might have allowed the species of Geranium to increase in geographic range and to ultimately, diversify.
[Mh] Termos MeSH primário: Biodiversidade
Frutas/anatomia & histologia
Geranium/anatomia & histologia
Geranium/classificação
Filogenia
[Mh] Termos MeSH secundário: Sequência de Bases
Teorema de Bayes
DNA de Cloroplastos/genética
DNA de Plantas/genética
DNA Ribossômico/genética
Geranium/genética
Modelos Biológicos
Filogeografia
Sementes/anatomia & histologia
Análise de Sequência de DNA
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast); 0 (DNA, Plant); 0 (DNA, Ribosomal)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


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[PMID]:28193226
[Au] Autor:Boisvert WA; Yu M; Choi Y; Jeong GH; Zhang YL; Cho S; Choi C; Lee S; Lee BH
[Ad] Endereço:John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, 96813, USA.
[Ti] Título:Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice.
[So] Source:BMC Complement Altern Med;17(1):109, 2017 Feb 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Geranium sibiricum L. has been used as a medicinal plant to treat diarrhea, bacterial infection, and cancer in Bulgaria, Peru, and Korea. However, its hair growth-promoting effect was not investigated so far. This study examined the effects of Geranium sibiricum L. extract (GSE) on hair growth, using in vitro and in vivo models. METHODS: Antioxidant, proliferation and migration assay of GSE was performed with human dermal papilla cells (hDPCs). Hair-growth promoting effect was measured in animal model. Relative expression of interleukin-1, vascular endothelial growth factor, hepatocyte growth factor, and transforming growth factor beta 1 was determined by real time RT-PCR. Expression of Ki-67 and stem cell factor were analyzed by immunohistochemistry. RESULTS: GSE treatment proliferated and migrated human dermal papilla cells (hDPCs) more than treatment of 10 µM minoxidil. GSE significantly stimulated the expression of Ki-67 protein and the mRNA levels of hepatocyte growth factor and vascular endothelial growth factor in hDPCs. Topical application of 1,000 ppm GSE for 3 weeks promoted more significant hair growth on shaved C57BL/6 mice than did 5% minoxidil. The histological morphology of hair follicles demonstrated an active anagen phase with the induction of stem cell factor. GSE treatment significantly reduced the number of mast cells and the expression of transforming growth factor beta 1 in mouse skin tissues. CONCLUSIONS: These results demonstrated that GSE promotes hair growth in vitro and in vivo by regulating growth factors and the cellular response.
[Mh] Termos MeSH primário: Derme/efeitos dos fármacos
Geranium
Cabelo/efeitos dos fármacos
Fator de Crescimento de Hepatócito/metabolismo
Extratos Vegetais/farmacologia
Fator de Crescimento Transformador beta1/metabolismo
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Mh] Termos MeSH secundário: Animais
Movimento Celular
Proliferação Celular
Células Cultivadas
Derme/metabolismo
Cabelo/crescimento & desenvolvimento
Folículo Piloso/efeitos dos fármacos
Fator de Crescimento de Hepatócito/genética
Seres Humanos
Antígeno Ki-67/metabolismo
Masculino
Mastócitos/metabolismo
Camundongos Endogâmicos C57BL
RNA Mensageiro/metabolismo
Fator de Células-Tronco/metabolismo
Fator A de Crescimento do Endotélio Vascular/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ki-67 Antigen); 0 (Plant Extracts); 0 (RNA, Messenger); 0 (Stem Cell Factor); 0 (Transforming Growth Factor beta1); 0 (Vascular Endothelial Growth Factor A); 67256-21-7 (Hepatocyte Growth Factor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170223
[Lr] Data última revisão:
170223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1624-4


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[PMID]:28086783
[Au] Autor:Narnoliya LK; Kaushal G; Singh SP; Sangwan RS
[Ad] Endereço:Center of Innovative and Applied Bioprocessing (A National Institute under the Department of Biotechnology, Govt. of India), S.A.S. Nagar, Mohali, Punjab, India.
[Ti] Título:De novo transcriptome analysis of rose-scented geranium provides insights into the metabolic specificity of terpene and tartaric acid biosynthesis.
[So] Source:BMC Genomics;18(1):74, 2017 01 13.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rose-scented geranium (Pelargonium sp.) is a perennial herb that produces a high value essential oil of fragrant significance due to the characteristic compositional blend of rose-oxide and acyclic monoterpenoids in foliage. Recently, the plant has also been shown to produce tartaric acid in leaf tissues. Rose-scented geranium represents top-tier cash crop in terms of economic returns and significance of the plant and plant products. However, there has hardly been any study on its metabolism and functional genomics, nor any genomic expression dataset resource is available in public domain. Therefore, to begin the gains in molecular understanding of specialized metabolic pathways of the plant, de novo sequencing of rose-scented geranium leaf transcriptome, transcript assembly, annotation, expression profiling as well as their validation were carried out. RESULTS: De novo transcriptome analysis resulted a total of 78,943 unique contigs (average length: 623 bp, and N50 length: 752 bp) from 15.44 million high quality raw reads. In silico functional annotation led to the identification of several putative genes representing terpene, ascorbic acid and tartaric acid biosynthetic pathways, hormone metabolism, and transcription factors. Additionally, a total of 6,040 simple sequence repeat (SSR) motifs were identified in 6.8% of the expressed transcripts. The highest frequency of SSR was of tri-nucleotides (50%). Further, transcriptome assembly was validated for randomly selected putative genes by standard PCR-based approach. In silico expression profile of assembled contigs were validated by real-time PCR analysis of selected transcripts. CONCLUSION: Being the first report on transcriptome analysis of rose-scented geranium the data sets and the leads and directions reflected in this investigation will serve as a foundation for pursuing and understanding molecular aspects of its biology, and specialized metabolic pathways, metabolic engineering, genetic diversity as well as molecular breeding.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica
Geranium/genética
Geranium/metabolismo
Tartaratos/metabolismo
Terpenos/metabolismo
Transcriptoma
[Mh] Termos MeSH secundário: Análise por Conglomerados
Biologia Computacional/métodos
Ontologia Genética
Sequenciamento de Nucleotídeos em Larga Escala
Redes e Vias Metabólicas
Repetições de Microssatélites
Anotação de Sequência Molecular
Fenótipo
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Tartrates); 0 (Terpenes); W4888I119H (tartaric acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-016-3437-0


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[PMID]:27580641
[Au] Autor:Jadaun JS; Sangwan NS; Narnoliya LK; Singh N; Bansal S; Mishra B; Sangwan RS
[Ad] Endereço:Department of Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow 226015, India.
[Ti] Título:Over-expression of DXS gene enhances terpenoidal secondary metabolite accumulation in rose-scented geranium and Withania somnifera: active involvement of plastid isoprenogenic pathway in their biosynthesis.
[So] Source:Physiol Plant;159(4):381-400, 2017 Apr.
[Is] ISSN:1399-3054
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Rose-scented geranium (Pelargonium spp.) is one of the most important aromatic plants and is well known for its diverse perfumery uses. Its economic importance is due to presence of fragrance rich essential oil in its foliage. The essential oil is a mixture of various volatile phytochemicals which are mainly terpenes (isoprenoids) in nature. In this study, on the geranium foliage genes related to isoprenoid biosynthesis (DXS, DXR and HMGR) were isolated, cloned and confirmed by sequencing. Further, the first gene of 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway, 1-deoxy-d-xylulose-5-phosphate synthase (GrDXS), was made full length by using rapid amplification of cDNA ends strategy. GrDXS contained a 2157 bp open reading frame that encoded a polypeptide of 792 amino acids having calculated molecular weight 77.5 kDa. This study is first report on heterologous expression and kinetic characterization of any gene from this economically important plant. Expression analysis of these genes was performed in different tissues as well as at different developmental stages of leaves. In response to external elicitors, such as methyl jasmonate, salicylic acid, light and wounding, all the three genes showed differential expression profiles. Further GrDXS was over expressed in the homologous (rose-scented geranium) as well as in heterologous (Withania somnifera) plant systems through genetic transformation approach. The over-expression of GrDXS led to enhanced secondary metabolites production (i.e. essential oil in rose-scented geranium and withanolides in W. somnifera). To the best of our knowledge, this is the first report showing the expression profile of the three genes related to isoprenoid biosynthesis pathways operated in rose-scented geranium as well as functional characterization study of any gene from rose-scented geranium through a genetic transformation system.
[Mh] Termos MeSH primário: Vias Biossintéticas/genética
Butadienos/metabolismo
Genes de Plantas
Geranium/genética
Hemiterpenos/metabolismo
Pentanos/metabolismo
Plastídeos/metabolismo
Metabolismo Secundário/genética
Terpenos/metabolismo
Withania/genética
[Mh] Termos MeSH secundário: Acetatos/farmacologia
Sequência de Bases
Biocatálise/efeitos dos fármacos
Vias Biossintéticas/efeitos dos fármacos
Vias Biossintéticas/efeitos da radiação
Clonagem Molecular
Biologia Computacional
Ciclopentanos/farmacologia
Evolução Molecular
Perfilação da Expressão Gênica
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Regulação da Expressão Gênica de Plantas/efeitos da radiação
Geranium/efeitos dos fármacos
Geranium/efeitos da radiação
Luz
Oxilipinas/farmacologia
Filogenia
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Plastídeos/efeitos dos fármacos
Plastídeos/efeitos da radiação
Proteínas Recombinantes/metabolismo
Metabolismo Secundário/efeitos dos fármacos
Metabolismo Secundário/efeitos da radiação
Alinhamento de Sequência
Análise de Sequência de DNA
Homologia Estrutural de Proteína
Withania/efeitos dos fármacos
Withania/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Butadienes); 0 (Cyclopentanes); 0 (Hemiterpenes); 0 (Oxylipins); 0 (Pentanes); 0 (Plant Proteins); 0 (Recombinant Proteins); 0 (Terpenes); 0A62964IBU (isoprene); 900N171A0F (methyl jasmonate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1111/ppl.12507


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[PMID]:27864260
[Au] Autor:Varga S; Kytöviita MM
[Ad] Endereço:Department of Biological and Environmental Science, University of Jyvaskyla, P.O. Box 35 40014 Jyvaskyla, Finland svarga@lincoln.ac.uk sandravarga30@hotmail.com.
[Ti] Título:Light availability affects sex lability in a gynodioecious plant.
[So] Source:Am J Bot;103(11):1928-1936, 2016 Nov.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Sex lability (i.e., gender diphasy) in plants is classically linked to the larger resource needs associated with the female sexual function (i.e., seed production) compared to the male function (i.e., pollen production). Sex lability in response to the environment is extensively documented in dioecious species, but has been largely overlooked in gynodioecious plants. METHODS: Here, we tested whether environmental conditions induce sex lability in the gynodioecious Geranium sylvaticum. We conducted a transplantation experiment in the field where plants with different sex expression were reciprocally transplanted between high light and low light habitats. We measured plants' reproductive output and sex expression over four years. KEY RESULTS: Our results show that sex expression was labile over the study period. The light level at the destination habitat had a significant effect on sexual expression and reproductive output, because plants decreased their reproductive output when transplanted to the low light habitat. Transplantation origin did not affect any parameter measured. CONCLUSIONS: This study shows that sex expression in Geranium sylvaticum is labile and related to light availability. Sexually labile plants did not produce more seeds or pollen, and thus, there was no apparent fitness gain in sexually labile individuals. Sex lability in gynodioecious plants may be more common than previously believed because detection of sex lability necessitates data on the same individuals over time, which is rare in sexually dimorphic herbaceous plants.
[Mh] Termos MeSH primário: Geranium/fisiologia
[Mh] Termos MeSH secundário: Ecossistema
Geranium/efeitos da radiação
Luz
Pólen/fisiologia
Pólen/efeitos da radiação
Reprodução
Sementes/fisiologia
Sementes/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


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[PMID]:26927807
[Au] Autor:Kobayashi Y; Sato H; Yorita M; Nakayama H; Miyazato H; Sugimoto K; Jippo T
[Ad] Endereço:a Faculty of Human Life Sciences, Department of Food and Nutrition , Senri Kinran University , Suita , Japan.
[Ti] Título:Inhibitory effects of geranium essential oil and its major component, citronellol, on degranulation and cytokine production by mast cells.
[So] Source:Biosci Biotechnol Biochem;80(6):1172-8, 2016 Jun.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We investigated the effects of geranium essential oil (GEO) on anaphylaxis. GEO can exert antioxidant and anti-inflammatory effects, but its roles in allergic reactions are incompletely understood. Here, we used mouse cells to show that GEO inhibited the degranulation of cultured mast cells (CMCs). Citronellol is the major component of GEO and inhibited CMC degranulation. The l-enantiomer of citronellol more effectively suppressed CMC degranulation than did d-citronellol. We also examined whether citronellol could inhibit the immunoglobulin (Ig) E-induced production of tumor necrosis factor (TNF)-α. Treatment with various concentrations of citronellol before CMC activation with IgE significantly inhibited the induction of TNF-α in a dose-dependent manner. Mechanistically, citronellol suppressed the phosphorylation of mitogen-activated protein kinase (ERK), which is critical for ERK activation and the production of inflammatory cytokines in mast cells. These findings suggest that citronellol may represent a candidate compound for the effective treatment of allergic diseases.
[Mh] Termos MeSH primário: Degranulação Celular/efeitos dos fármacos
Geranium/química
Mastócitos/efeitos dos fármacos
Monoterpenos/farmacologia
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Animais
Citocinas/antagonistas & inibidores
Citocinas/genética
Citocinas/imunologia
Relação Dose-Resposta a Droga
MAP Quinases Reguladas por Sinal Extracelular/antagonistas & inibidores
MAP Quinases Reguladas por Sinal Extracelular/genética
MAP Quinases Reguladas por Sinal Extracelular/imunologia
Cromatografia Gasosa-Espectrometria de Massas
Regulação da Expressão Gênica
Imunoglobulina E/farmacologia
Masculino
Mastócitos/citologia
Mastócitos/imunologia
Camundongos
Camundongos Endogâmicos ICR
Fosforilação
Phytolacca americana/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Estereoisomerismo
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 37341-29-0 (Immunoglobulin E); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); P01OUT964K (citronellol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2016.1148573


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[PMID]:26703546
[Au] Autor:Lysakowska ME; Sienkiewicz M; Banaszek K; Sokolowski J
[Ad] Endereço:Department of Microbiology and Medical Laboratory Immunology, Medical University of Lodz, 92-231 Lodz, Pomorska 251, Poland. monika.lysakowska@umed.lodz.pl.
[Ti] Título:The Sensitivity of Endodontic Enterococcus spp. Strains to Geranium Essential Oil.
[So] Source:Molecules;20(12):22881-9, 2015 Dec 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Enterococci are able to survive endodontic procedures and contribute to the failure of endodontic therapy. Thus, it is essential to identify novel ways of eradicating them from infected root canals. One such approach may be the use of antimicrobials such as plant essential oils. Enterococcal strains were isolated from endodontically treated teeth by standard microbiological methods. Susceptibility to antibiotics was evaluated by the disc-diffusion method. The minimal inhibitory concentration (MIC) of geranium essential oil was investigated by microdilution in 96-well microplates in Mueller Hinton Broth II. Biofilm eradication concentrations were checked in dentin tests. Geranium essential oil inhibited enterococcal strains at concentrations ranging from 1.8-4.5 mg/mL. No correlation was shown between resistance to antibiotics and the MICs of the test antimicrobials. The MICs of the test oil were lower than those found to show cytotoxic effects on the HMEC-1 cell line. Geranium essential oil eradicated enterococcal biofilm at concentrations of 150 mg/mL. Geranium essential oil inhibits the growth of endodontic enterococcal species at lower concentrations than those required to reach IC50 against the HMEC-1 cell line, and is effective against bacteria protected in biofilm at higher concentrations. In addition, bacteria do not develop resistance to essential oils. Hence, geranium essential oil represents a possible alternative to other antimicrobials during endodontic procedures.
[Mh] Termos MeSH primário: Endoderma/microbiologia
Enterococcus/efeitos dos fármacos
Geranium/química
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Anti-Infecciosos/farmacologia
Biofilmes/efeitos dos fármacos
Linhagem Celular
Seres Humanos
Testes de Sensibilidade Microbiana/métodos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151225
[Lr] Data última revisão:
151225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151226
[St] Status:MEDLINE
[do] DOI:10.3390/molecules201219888



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