Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.475.500 [Categoria DeCS]
Referências encontradas : 30 [refinar]
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  1 / 30 MEDLINE  
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[PMID]:26423504
[Au] Autor:Mouchrek Junior JC; Nunes LH; Arruda CS; Rizzi Cde C; Mouchrek AQ; Tavarez RR; Tonetto MR; Bandeca MC; Maia Filho EM
[Ad] Endereço:Department of Dentistry, CEUMA University, Sao Luis, MA Brazil.
[Ti] Título:Effectiveness of Oral Antiseptics on Tooth Biofilm: A Study in vivo.
[So] Source:J Contemp Dent Pract;16(8):674-8, 2015 08 01.
[Is] ISSN:1526-3711
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:AIM: To evaluate the effectiveness of five different mouthwashes through measurement of the plaque index. MATERIALS AND METHODS: Fifty subjects took part in this blind study, randomized into blocks of five groups according to the active ingredient of the mouthwash: CHX group (0.12% chlorhexidine gluconate), essential oils (EO) group, cetylpyridinium chloride (CPC) group, Tri group (triclosan) and Hamamelis virginiana (HV) group. All subjects were evaluated for a reduction in the bacterial plaque index at 7, 14 and 21 days. RESULTS: There was a significant reduction in the mean plaque index during the period of evaluation (p < 0.01), and the reduction during the period of evaluation was different between mouthwashes (p < 0.01). The reduction in the plaque index at the end of 21 days was, in decreasing order, CHX > EO > CPC > Tri > HV. CONCLUSION: The reduction in the plaque index during the period of evaluation was different between the types of mouth-wash. The mouthwash containing the active ingredient chlorhexidine was the most effective, followed by the essential oil, cetylpyridinium chloride, triclosan and H. virginiana.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/administração & dosagem
Biofilmes/efeitos dos fármacos
Placa Dentária/prevenção & controle
Antissépticos Bucais/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Biofilmes/crescimento & desenvolvimento
Cetilpiridínio/administração & dosagem
Clorexidina/administração & dosagem
Clorexidina/análogos & derivados
Placa Dentária/microbiologia
Método Duplo-Cego
Feminino
Hamamelis/química
Seres Humanos
Masculino
Óleos Voláteis/administração & dosagem
Triclosan/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Mouthwashes); 0 (Oils, Volatile); 4NM5039Y5X (Triclosan); CUB7JI0JV3 (Cetylpyridinium); MOR84MUD8E (chlorhexidine gluconate); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170506
[Lr] Data última revisão:
170506
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:151002
[St] Status:MEDLINE


  2 / 30 MEDLINE  
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[PMID]:25600644
[Au] Autor:Gangemi S; Minciullo PL; Miroddi M; Chinou I; Calapai G; Schmidt RJ
[Ad] Endereço:Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy; Operative Unit of Allergy and Clinical Immunology, Azienda Ospedaliera Universitaria Policlinico 'G. Martino', Via Consolare Valeria, 98125 Messina, Italy; Institute of Clinical Physiology, IFC CNR, Messina Unit, Via Consolare Valeria, 98125 Messina, Italy.
[Ti] Título:Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 2: Echinacea purpurea-Lavandula angustifolia.
[So] Source:Contact Dermatitis;72(4):193-205, 2015 Apr.
[Is] ISSN:1600-0536
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph has been produced. Part 2: Echinacea purpurea Moench-Lavandula angustifolia Mill.
[Mh] Termos MeSH primário: Dermatite de Contato/etiologia
Echinacea/efeitos adversos
Lavandula/efeitos adversos
Preparações de Plantas/efeitos adversos
[Mh] Termos MeSH secundário: Europa (Continente)
Hamamelis/efeitos adversos
Hedera/efeitos adversos
Seres Humanos
Humulus/efeitos adversos
Hypericum/efeitos adversos
Juniperus/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150326
[Lr] Data última revisão:
150326
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150121
[St] Status:MEDLINE
[do] DOI:10.1111/cod.12328


  3 / 30 MEDLINE  
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[PMID]:24498245
[Au] Autor:Theisen LL; Erdelmeier CA; Spoden GA; Boukhallouk F; Sausy A; Florin L; Muller CP
[Ad] Endereço:Institute of Immunology, Centre de Recherche Public de la Santé/Laboratoire National de Santé, Luxembourg, Luxembourg.
[Ti] Título:Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus.
[So] Source:PLoS One;9(1):e88062, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antiviral activity has been demonstrated for different tannin-rich plant extracts. Since tannins of different classes and molecular weights are often found together in plant extracts and may differ in their antiviral activity, we have compared the effect against influenza A virus (IAV) of Hamamelis virginiana L. bark extract, fractions enriched in tannins of different molecular weights and individual tannins of defined structures, including pseudotannins. We demonstrate antiviral activity of the bark extract against different IAV strains, including the recently emerged H7N9, and show for the first time that a tannin-rich extract inhibits human papillomavirus (HPV) type 16 infection. As the best performing antiviral candidate, we identified a highly potent fraction against both IAV and HPV, enriched in high molecular weight condensed tannins by ultrafiltration, a simple, reproducible and easily upscalable method. This ultrafiltration concentrate and the bark extract inhibited early and, to a minor extent, later steps in the IAV life cycle and tannin-dependently inhibited HPV attachment. We observed interesting mechanistic differences between tannin structures: High molecular weight tannin containing extracts and tannic acid (1702 g/mol) inhibited both IAV receptor binding and neuraminidase activity. In contrast, low molecular weight compounds (<500 g/mol) such as gallic acid, epigallocatechin gallate or hamamelitannin inhibited neuraminidase but not hemagglutination. Average molecular weight of the compounds seemed to positively correlate with receptor binding (but not neuraminidase) inhibition. In general, neuraminidase inhibition seemed to contribute little to the antiviral activity. Importantly, antiviral use of the ultrafiltration fraction enriched in high molecular weight condensed tannins and, to a lesser extent, the unfractionated bark extract was preferable over individual isolated compounds. These results are of interest for developing and improving plant-based antivirals.
[Mh] Termos MeSH primário: Antivirais
Hamamelis/química
Papillomavirus Humano 16/metabolismo
Vírus da Influenza A/metabolismo
Influenza Humana/tratamento farmacológico
Infecções por Papillomavirus/tratamento farmacológico
Casca de Planta/química
Extratos Vegetais
Taninos
[Mh] Termos MeSH secundário: Animais
Antivirais/química
Antivirais/farmacologia
Cães
Seres Humanos
Influenza Humana/metabolismo
Influenza Humana/patologia
Células Madin Darby de Rim Canino
Infecções por Papillomavirus/metabolismo
Infecções por Papillomavirus/patologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Taninos/química
Taninos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts); 0 (Tannins)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0088062


  4 / 30 MEDLINE  
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[PMID]:23399119
[Au] Autor:Rocasalbas G; Francesko A; Touriño S; Fernández-Francos X; Guebitz GM; Tzanov T
[Ad] Endereço:Group of Molecular and Industrial Biotechnology, Department of Chemical Engineering, Universitat Politècnica de Catalunya, Passeig Ernest Lluch/Rambla Sant Nebridi s/n, 08222 Terrassa, Spain.
[Ti] Título:Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols.
[So] Source:Carbohydr Polym;92(2):989-96, 2013 Feb 15.
[Is] ISSN:1879-1344
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Laccase-assisted simultaneous cross-linking and functionalization of chitosan/gelatin blends with phenolic compounds from Hamamelis virginiana was investigated for the development of bioactive hydrogel dressings. The potential of these hydrogels for chronic wound treatment was evaluated in vitro, assessing their antibacterial and inhibitory effect on myeloperoxidase and collagenase. Rheological studies revealed that the mechanical properties of the hydrogels were a function of the enzymatic reaction time. Stable hydrogels and resistant to lysozyme degradation were achieved after 2 h laccase reaction. The inhibitory capacity of the hydrogel for myeloperoxidase and collagenase was 32% and 79% respectively after 24 h incubation. Collagenase activity was additionally suppressed by adsorption (20%) of the enzyme onto the hydrogel. Therefore, the bioactive properties of the hydrogels were due to the effect of both released phenolic compounds and the permanently functionalized platform itself. The hydrogels showed antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
[Mh] Termos MeSH primário: Biocatálise
Quitosana/metabolismo
Gelatina/metabolismo
Hamamelis/química
Hidrogéis/metabolismo
Lacase/metabolismo
Polifenóis/metabolismo
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/metabolismo
Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Infecções Bacterianas/tratamento farmacológico
Bandagens/microbiologia
Estabilidade de Medicamentos
Inibidores Enzimáticos/química
Inibidores Enzimáticos/metabolismo
Inibidores Enzimáticos/farmacologia
Inibidores Enzimáticos/uso terapêutico
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/metabolismo
Depuradores de Radicais Livres/farmacologia
Depuradores de Radicais Livres/uso terapêutico
Seres Humanos
Lacase/química
Metaloproteinases da Matriz/metabolismo
Fenômenos Mecânicos
Oxirredução
Peroxidase/antagonistas & inibidores
Polifenóis/química
Polifenóis/farmacologia
Polifenóis/uso terapêutico
Trametes/enzimologia
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Enzyme Inhibitors); 0 (Free Radical Scavengers); 0 (Hydrogels); 0 (Polyphenols); 9000-70-8 (Gelatin); 9012-76-4 (Chitosan); EC 1.10.3.2 (Laccase); EC 1.11.1.7 (Peroxidase); EC 3.4.24.- (Matrix Metalloproteinases)
[Em] Mês de entrada:1308
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130213
[St] Status:MEDLINE


  5 / 30 MEDLINE  
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[PMID]:23062397
[Au] Autor:Weber RW
[Ad] Endereço:National Jewish Health, 1400 Jackson Street Room J326, Denver, CO 80206, USA.
[Ti] Título:Allergen of the month--witch hazel.
[So] Source:Ann Allergy Asthma Immunol;109(5):A17, 2012 Nov.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/imunologia
Hamamelidaceae/imunologia
Hamamelis/imunologia
Pólen/imunologia
[Mh] Termos MeSH secundário: Alérgenos/efeitos adversos
Alérgenos/uso terapêutico
Hamamelidaceae/efeitos adversos
Hamamelis/efeitos adversos
Seres Humanos
Filogenia
Fitoterapia
Pólen/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1212
[Cu] Atualização por classe:121015
[Lr] Data última revisão:
121015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121016
[St] Status:MEDLINE


  6 / 30 MEDLINE  
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[PMID]:22532245
[Au] Autor:Rehill BJ; Schultz JC
[Ad] Endereço:Pesticide Research Laboratory, Department of Entomology, The Pennsylvania State University, University Park, PA 16802, USA. rehill@usna.edu
[Ti] Título:Hormaphis hamamelidis fundatrices benefit by manipulating phenolic metabolism of their host.
[So] Source:J Chem Ecol;38(5):496-8, 2012 May.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the pattern and potential adaptive value of phenolic concentrations in galls induced by the aphid Hormaphis hamamelidis on leaves of Hamamelis virginiana. By the time that founding females began reproduction, galls had higher concentrations of condensed tannins and lower concentrations of hydrolyzable tannins than leaves. Galled and ungalled leaf laminas never differed significantly in any phenolic measure. Condensed tannin concentrations also were positively related to the number of offspring per gall when gall dry weight, another important correlate of fecundity, was accounted for. This could indicate the prior sink strength of the gall. Polyphenols may act as a repository for excess carbon drawn to the gall by increased sink strength, or be an indication of the fundatrix' ability to manipulate host physiology. This study is the first to demonstrate a tangible, quantitative association between phenolic accumulation in galls and gall-former reproductive performance, and illustrates that condensed tannins may play roles other than plant defense.
[Mh] Termos MeSH primário: Afídeos/fisiologia
Hamamelis/parasitologia
Interações Hospedeiro-Parasita
Fenóis/metabolismo
Folhas de Planta/parasitologia
[Mh] Termos MeSH secundário: Animais
Feminino
Hamamelis/metabolismo
Folhas de Planta/metabolismo
Taninos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Phenols); 0 (Tannins)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120426
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-012-0115-9


  7 / 30 MEDLINE  
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[PMID]:22434718
[Au] Autor:Duckstein SM; Lorenz P; Stintzing FC
[Ad] Endereço:WALA Heilmittel GmbH, Department of Research and Development, Dorfstrasse 1, D-73087, Bad Boll/Eckwälden, Germany.
[Ti] Título:Conversion of phenolic constituents in aqueous Hamamelis virginiana leaf extracts during fermentation.
[So] Source:Phytochem Anal;23(6):588-97, 2012 Nov-Dec.
[Is] ISSN:1099-1565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Hamamelis virginiana, known for its high level of tannins and other phenolics is widely used for treatment of dermatological disorders. Although reports on hydroalcoholic and aqueous extracts from Hamamelis leaf and bark exist, knowledge on fermented leaf preparations and the underlying conversion processes are still scant. OBJECTIVE: Aqueous Hamamelis leaf extracts were monitored during fermentation and maturation in order to obtain an insight into the bioconversion of tannins and other phenolics. METHODOLOGY: Aliquots taken during the production period were investigated by HPLC-DAD-MS/MS as well as GC-MS after derivatisation into the corresponding trimethylsilyl compounds. RESULTS: In Hamamelis leaf extracts, the main constituents exhibited changes during the observational period of 6 months. By successive depside bond cleavage, the gallotannins were completely transformed into gallic acid after 1 month. Although not completely, kaempferol and quercetin glycosides were also converted during 6 months to yield their corresponding aglycones. Following C-ring fission, phloroglucinol was formed from the A-ring of both flavonols. The B-ring afforded 3-hydroxybenzoic acid from quercetin and 3,4-dihydroxybenzoic acid as well as 2-(4-hydroxyphenyl)-ethanol from kaempferol. Interestingly, hydroxycinnamic acids remained almost stable in the same time range. CONCLUSION: The present study broadens the knowledge on conversion processes in aqueous fermented extracts containing tannins, flavonol glycosides and hydroxycinnamic acids. In particular, the analogy between the microbial metabolism of phenolics from fermented Hamamelis extracts, fermented sourdough by heterofermentative lactic acid bacteria or conversion of phenolics by the human microbial flora is indicated.
[Mh] Termos MeSH primário: Flavonóis/metabolismo
Hamamelis/química
Taninos Hidrolisáveis/metabolismo
Fenóis/metabolismo
Extratos Vegetais/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Ácidos Cumáricos/metabolismo
Fermentação
Flavonóis/análise
Ácido Gálico/análise
Ácido Gálico/metabolismo
Cromatografia Gasosa-Espectrometria de Massas
Glicosídeos/análise
Glicosídeos/metabolismo
Taninos Hidrolisáveis/análise
Hidroxibenzoatos/metabolismo
Quempferóis/metabolismo
Extratos Vegetais/análise
Folhas de Planta/metabolismo
Plantas Medicinais/química
Quercetina/análise
Quercetina/metabolismo
Espectrometria de Massas em Tandem
Taninos/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumaric Acids); 0 (Flavonols); 0 (Glycosides); 0 (Hydrolyzable Tannins); 0 (Hydroxybenzoates); 0 (Kaempferols); 0 (Phenols); 0 (Plant Extracts); 0 (Tannins); 2ZFW40OJ7U (3-hydroxybenzoic acid); 632XD903SP (Gallic Acid); 731P2LE49E (kaempferol); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120322
[St] Status:MEDLINE
[do] DOI:10.1002/pca.2359


  8 / 30 MEDLINE  
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[PMID]:22216935
[Au] Autor:Sánchez-Tena S; Fernández-Cachón ML; Carreras A; Mateos-Martín ML; Costoya N; Moyer MP; Nuñez MJ; Torres JL; Cascante M
[Ad] Endereço:Faculty of Biology, Universitat de Barcelona, IBUB, Unit Associated with CSIC, 08028 Barcelona, Spain.
[Ti] Título:Hamamelitannin from witch hazel (Hamamelis virginiana) displays specific cytotoxic activity against colon cancer cells.
[So] Source:J Nat Prod;75(1):26-33, 2012 Jan 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hamamelis virginiana (witch hazel) bark is a rich source of condensed and hydrolyzable tannins reported to exert a protective action against colon cancer. The present study characterizes different witch hazel tannins as selective cytotoxic agents against colon cancer. To cover the structural diversity of the tannins that occur in H. virginiana bark, the hydrolyzable tannins, hamamelitannin and pentagalloylglucose, together with a proanthocyanidin-rich fraction (F800H4) were selected for the study. Treatment with these compounds reduced tumor viability and induced apoptosis, necrosis, and S-phase arrest in the cell cycle of HT29 cells, with hamamelitannin being the most efficient. Owing to polyphenol-mediated H(2)O(2) formation in the incubation media, the antiproliferative effect was determined in the presence and absence of catalase to rule out any such interference. The presence of catalase significantly changed the IC(50) only for F800H4. Furthermore, at concentrations that inhibit the growth of HT29 cells by 50%, hamamelitannin had no harmful effects on NCM460 normal colonocytes, whereas pentagalloylglucose inhibited both cancerous and normal cell growth. Using the TNPTM assay, we identified a highly reactive phenolic position in hamamelitannin, which may explain its efficacy at inhibiting colon cancer growth.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Ácido Gálico/análogos & derivados
Hamamelis/química
Hexoses/isolamento & purificação
Hexoses/farmacologia
Taninos Hidrolisáveis/isolamento & purificação
Taninos Hidrolisáveis/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Apoptose/efeitos dos fármacos
Neoplasias do Colo
Ensaios de Seleção de Medicamentos Antitumorais
Ácido Gálico/química
Ácido Gálico/isolamento & purificação
Ácido Gálico/farmacologia
Hexoses/química
Seres Humanos
Peróxido de Hidrogênio/análise
Taninos Hidrolisáveis/química
Estrutura Molecular
Casca de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Hexoses); 0 (Hydrolyzable Tannins); 632XD903SP (Gallic Acid); BBX060AN9V (Hydrogen Peroxide); Z4320A2K26 (hamamelitannin)
[Em] Mês de entrada:1203
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120106
[St] Status:MEDLINE
[do] DOI:10.1021/np200426k


  9 / 30 MEDLINE  
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[PMID]:22251718
[Au] Autor:Yitbarek S; Vandermeer JH; Allen D
[Ad] Endereço:Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA. senay@umich.edu
[Ti] Título:The combined effects of exogenous and endogenous variability on the spatial distribution of ant communities in a forested ecosystem (Hymenoptera: Formicidae).
[So] Source:Environ Entomol;40(5):1067-73, 2011 Oct.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Spatial patterns observed in ecosystems have traditionally been attributed to exogenous processes. Recently, ecologists have found that endogenous processes also have the potential to create spatial patterns. Yet, relatively few studies have attempted to examine the combined effects of exogenous and endogenous processes on the distribution of organisms across spatial and temporal scales. Here we aim to do this, by investigating whether spatial patterns of under-story tree species at a large spatial scale (18 ha) influences the spatial patterns of ground foraging ant species at a much smaller spatial scale (20 m by 20 m). At the regional scale, exogenous processes (under-story tree community) had a strong effect on the spatial patterns in the ground-foraging ant community. We found significantly more Camponotus noveboracensis, Formica subsericae, and Lasius alienus species in black cherry (Prunis serotine Ehrh.) habitats. In witch-hazel (Hamamelis virginiana L.) habitats, we similarly found significantly more Myrmica americana, Formica fusca, and Formica subsericae. At smaller spatial scales, we observed the emergence of mosaic ant patches changing rapidly in space and time. Our study reveals that spatial patterns are the result of both exogenous and endogenous forces, operating at distinct scales.
[Mh] Termos MeSH primário: Formigas
Comportamento Competitivo
Ecossistema
Árvores
[Mh] Termos MeSH secundário: Acer
Animais
Hamamelis
Michigan
Dinâmica Populacional
Prunus
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1205
[Cu] Atualização por classe:120118
[Lr] Data última revisão:
120118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120119
[St] Status:MEDLINE
[do] DOI:10.1603/EN11058


  10 / 30 MEDLINE  
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[PMID]:21805643
[Au] Autor:Antonio F; Guillem R; Sonia T; Clara M; Piergiorgio G; Valeria C; Gianluca C; Tzanov T
[Ad] Endereço:Group of Molecular and Industrial Biotechnology, Department of Chemical Engineering, Universitat Politècnica de Catalunya, Terrassa, Spain.
[Ti] Título:Cross-linked collagen sponges loaded with plant polyphenols with inhibitory activity towards chronic wound enzymes.
[So] Source:Biotechnol J;6(10):1208-18, 2011 Oct.
[Is] ISSN:1860-7314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Collagen sponges loaded with polyphenols from Hamamelis virginiana were investigated as active materials for chronic wound dressings, evaluating in vitro the inhibition of two major enzymes that impair the wound healing process - myeloperoxidase (MPO) and collagenase. Prior to polyphenols loading, collagen was cross-linked with genipin to improve its biostability. The effect of genipin cross-linking and polyphenol concentration in the development of mechanically and enzymatically stable sponges was studied. The tensile strength of the cross-linked collagen increased with the increase of the cross-linking degree, coupled to decrease in the elongation and the swelling capacity of the sponges. The stability of the sponges to collagenase digestion reached maximum when 1 mM genipin was used. However, the biostability decreased more than 10-fold after loading the sponges with polyphenols (0.5 mg/mL), nevertheless, this effect was partially overcome using higher concentration of polyphenols (1 and 2 mg/mL) to inhibit collagenase. Moreover, the polyphenols released from the sponges were sufficient for complete inhibition of MPO activity. No considerable cytotoxicity of the genipin cross-linked collagen loaded with polyphenols was observed evaluating the NIH 3T3 fibroblasts viability.
[Mh] Termos MeSH primário: Bandagens
Colágeno Tipo I/química
Inibidores de Metaloproteinases de Matriz
Peroxidase/antagonistas & inibidores
Polifenóis/administração & dosagem
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Materiais Biocompatíveis/administração & dosagem
Materiais Biocompatíveis/química
Doença Crônica
Reagentes para Ligações Cruzadas/química
Estabilidade de Medicamentos
Hamamelis/química
Glicosídeos Iridoides/química
Iridoides
Camundongos
Microscopia Eletrônica de Varredura
Células NIH 3T3
Tamanho da Partícula
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Caules de Planta/química
Polifenóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Collagen Type I); 0 (Cross-Linking Reagents); 0 (Iridoid Glycosides); 0 (Iridoids); 0 (Matrix Metalloproteinase Inhibitors); 0 (Plant Extracts); 0 (Polyphenols); A3V2NE52YG (genipin); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110802
[St] Status:MEDLINE
[do] DOI:10.1002/biot.201100194



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