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Pesquisa : B01.650.940.800.575.912.250.517 [Categoria DeCS]
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  1 / 16 MEDLINE  
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[PMID]:27825331
[Au] Autor:García-Alonso G; Monroy-Noyola A; Contreras-Arellano A; Mariscal-Durand JF; Gálvez-Molina Y; Vázquez-Velázquez A; García-Jimenez S; Nuñez P; Cardoso-Taketa A; Villarreal ML
[Ad] Endereço:Centro de Investigación en Biotecnología, Av. Universidad 1001. Col. Chamilpa, Cuernavaca, 62209, Morelos, México.
[Ti] Título:Preclinical evaluation of anti-Helicobacter spp. activity of Hippocratea celastroides Kunth and its acute and sub-acute toxicity.
[So] Source:BMC Complement Altern Med;16(1):445, 2016 Nov 08.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hippocratea celastroides Kunth, commonly known as "cancerina", is used in Mexican Traditional Medicine for the treatment of gastric and intestinal infections, systemic and skin inflammation, injuries and gastritis. The aim of this research was to assess the anti-Helicobacter pylori activities of hydro-ethanolic root-bark extracts from Hippocratea celastroides Kunth in naturally infected dogs, after testing their acute and subacute toxicities in mice. METHODS: To determine in vivo acute toxicity, a hydro-ethanolic extract was obtained and administered orally in female and male Balb-C mice, at doses ranging from 2000 to 5000 mg/kg. For the subacute study, a hydro-ethanolic extract was given to male and female Balb-C mice at doses ranging from 200 to 2000 mg/kg body weight. The animals were observed daily over a period of 42 days for signs of toxicity. In the pre-clinical anti-Helicobacter spp. assay, 60 dogs were included. Eighteen and 19 dogs for the experimental and control groups respectively, concluded the study. The experimental treatment consisted of H. celastroides hydro-ethanolic extract and the control treatment of amoxicillin-clarithromycin-omeprazole. RESULTS: Oral LD (lethal dose 50) values for hydro-ethanolic extract were indeterminable at the highest tested doses. Under the subacute administration, neither mortality nor any sign of toxicity were observed when the hydro-ethanolic extract was administered. There were no significant alterations in biochemical parameters. The prevalence of Helicobacter spp. infection in dogs was 97.1 % for the experimental group and 100 % for the control group. Effectiveness was of 33.3 and 55 % in the experimental and control group respectively. The oral administration of H. celastroides was well-tolerated and safe. CONCLUSION: The root-bark of H. celastroides produced no signs of toxicity, and manifested pharmacological activity that indicated the possibility of an alternative treatment for H. pylori infection. Effectiveness is still low so it is necessary to continue research.
[Mh] Termos MeSH primário: Infecções por Helicobacter/tratamento farmacológico
Helicobacter pylori/efeitos dos fármacos
Hippocrateaceae/química
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Cães
Avaliação Pré-Clínica de Medicamentos
Feminino
Infecções por Helicobacter/microbiologia
Helicobacter pylori/fisiologia
Hippocrateaceae/toxicidade
Seres Humanos
Dose Letal Mediana
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Extratos Vegetais/toxicidade
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


  2 / 16 MEDLINE  
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[PMID]:24971795
[Au] Autor:Hinojosa WI; Quiróz MA; Álvarez IR; Castañeda PE; Villarreal ML; Taketa AC
[Ad] Endereço:Centro de Investigación en Biotecnología. Universidad Autónoma del Estado de Morelos. Av. Universidad 1001. Col. Chamilpa. Cuernavaca 62209, Morelos, México.
[Ti] Título:Anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts of five different populations of Hippocratea celastroides collected in Mexico.
[So] Source:J Ethnopharmacol;155(2):1156-63, 2014 Sep 11.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The root barks of Hippocratea celastroides have been used for decades in Mexican traditional medicine to treat gastritis and ulcers. To investigate the anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts obtained from the leaves, stems, and root bark of Hippocratea celastroides collected in five different localities in Mexico, during the winter of 2009, in order to establish differences in biological activities in terms of plant organs, as well as places of collection. MATERIALS AND METHODS: Whole individuals were collected in five separate localities in Mexico: La Mancha, Veracruz (VL), Yautepec, Morelos (MY), Jojutla, Morelos (MJ), Temalac, Guerrero (GT), and Landa de Matamoros, Querétaro (QL). Methanolic crude extracts from wild plant specimens were tested using in vivo ethanol-induced mice gastric ulcer model, and 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ear edema in mice assay, and in vitro anti-Helicobacter pylori model, and carcinoma cell line cytotoxic assays. RESULTS AND CONCLUSIONS: The leaves, stems, and root bark from MY specimens, as well as the leaves and root bark of materials from VL, presented the highest activity against Helicobacter pylori (MIC values ranging from 7.81 to 31.25 µg/ml). Most gastroprotective effects were displayed by the leaves of plants collected in MY, with 89.85±1.91% of protection (300 mg/kg) and an ED50=27 mg/kg, which was corroborated by histological analysis. The root bark extracts from MY achieved the highest edema inhibition values (ED50=0.18 mg/ear), which were comparable to indomethacin (ED50=0.16 mg/ear). Finally, all extracts from MY (three plant parts) were cytotoxic against nasopharyngeal (KB), breast (MCF-7), and colon (HCT-116) carcinoma cell lines with IC50 values between 1.18 and 9.77 µg/ml, except that no activity was detected for root bark extracts against HCT-116 normal fibroblasts. The activities of methanolic extracts from leaves, stems and root bark of plants collected in five different locations varied considerably, representing a notable problem facing the quality control of the plant material from Hippocratea celastroides used for medicinal purposes. The ethnomedical information of this plant in regards to treating gastritis and ulcers was strongly evidenced by the findings of the experimental models employed in this study.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antiulcerosos/farmacologia
Hippocrateaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Antiulcerosos/administração & dosagem
Antiulcerosos/isolamento & purificação
Antineoplásicos Fitogênicos/administração & dosagem
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Modelos Animais de Doenças
Edema/tratamento farmacológico
Edema/patologia
Infecções por Helicobacter/tratamento farmacológico
Helicobacter pylori/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Masculino
Medicina Tradicional
México
Camundongos
Camundongos Endogâmicos ICR
Neoplasias/tratamento farmacológico
Neoplasias/patologia
Extratos Vegetais/administração & dosagem
Úlcera Gástrica/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Anti-Ulcer Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:140823
[Lr] Data última revisão:
140823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140628
[St] Status:MEDLINE


  3 / 16 MEDLINE  
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[PMID]:23530960
[Au] Autor:Okokon JE; Nwafor PA; Charles U; Dar A; Choudhary MI
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com
[Ti] Título:Antioxidative burst and hepatoprotective effects of ethanol root extract of Hippocratea africana against paracetamol-induced liver injury.
[So] Source:Pharm Biol;51(7):872-80, 2013 Jul.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Hippocratea africana (Willd.) Loes. ex Engl. (Celastraceae) root is used traditionally as an antipoison or antidote to treat liver diseases. OBJECTIVE: To evaluate antioxidative burst and hepatoprotective potentials of H. africana against paracetamol-induced liver injury in rats. MATERIALS AND METHOD: Antioxidative burst activity of the extract (1-100 µg/ml) in whole blood, neutrophils and macrophages was investigated using a luminol/lucigenin-based chemiluminescence assay. The hepatoprotective effect of the extract (200-600 mg/kg) was evaluated by the assay of liver function parameters, antioxidant enzymes and histopathological studies of the liver. GC-MS analyses of hexane and dichloromethane fractions were also carried out. RESULTS AND DISCUSSION: The root extract/fractions exerted pronounced inhibition of oxidative burst activity in whole blood, neutrophils (intracellular and extracellular) and macrophages (3.04-99.70%). The administration of the root extract caused significant (p < 0.05-0.001) reduction of high levels of liver enzymes (AST, ALT and ALP), total cholesterol, direct and total bilirubin as well as elevation of serum levels of total protein, albumin and antioxidant enzymes (SOD, CAT, GPx and GSH). Histology of the liver sections of extract and silymarin-treated animals showed reductions in the pathological features compared to the paracetamol-treated animals. The chemical pathological changes were consistent with histopathological observations suggesting a marked hepatoprotective effect of the root extract of H. africana. The GC-MS analysis revealed some pharmacologically active compounds. CONCLUSION: The results show that the root extract of H. africana has hepatoprotective potential probably due to its antioxidative burst activity.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Hippocrateaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetaminofen/toxicidade
Animais
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Relação Dose-Resposta a Droga
Etanol/química
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Testes de Função Hepática
Medições Luminescentes
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Masculino
Medicina Tradicional
Neutrófilos/efeitos dos fármacos
Neutrófilos/metabolismo
Extratos Vegetais/administração & dosagem
Raízes de Plantas
Substâncias Protetoras/administração & dosagem
Substâncias Protetoras/isolamento & purificação
Substâncias Protetoras/farmacologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents); 362O9ITL9D (Acetaminophen); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130328
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.768273


  4 / 16 MEDLINE  
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[PMID]:21454170
[Au] Autor:Okokon JE; Akpan HD; Umoh EE; Ekaidem IS
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, and Department of Chemical Pathology, University of Uyo Teaching Hospital, Uyo, Nigeria. judeefiom@yahoo.com
[Ti] Título:Antidiarrhoeal and antiulcer activities of Hippocratea africana root extract.
[So] Source:Pak J Pharm Sci;24(2):201-5, 2011 Apr.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The effect of ethanol root extract of H. africana on experimentally induced diarrhoea and ulcer was studied in rodents. The extract (200-600 mg/kg) considerably inhibited castor oil induced diarrhoea, small intestine transit time and castor oil induced fluid accumulation as well as indomethacin and ethanol induced ulcer models. The effect of the extract in these models was comparable to the various standard drugs used. The root extract of H. africana has antidiarrhoeal and antiulcer properties which justify its uses in ethnomedicine.
[Mh] Termos MeSH primário: Antiulcerosos/farmacologia
Antidiarreicos/farmacologia
Hippocrateaceae
Extratos Vegetais/farmacologia
Raízes de Plantas
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Fitoterapia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Antidiarrheals); 0 (Plant Extracts)
[Em] Mês de entrada:1105
[Cu] Atualização por classe:110401
[Lr] Data última revisão:
110401
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110402
[St] Status:MEDLINE


  5 / 16 MEDLINE  
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[PMID]:19406824
[Au] Autor:Rosa CA; Morais PB; Lachance MA; Santos RO; Melo WG; Viana RH; Bragança MA; Pimenta RS
[Ad] Endereço:Departamento de Microbiologia, ICB, C.P. 486, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. carlrosa@icb.ufmg.br
[Ti] Título:Wickerhamomyces queroliae sp. nov. and Candida jalapaonensis sp. nov., two yeast species isolated from Cerrado ecosystem in North Brazil.
[So] Source:Int J Syst Evol Microbiol;59(Pt 5):1232-6, 2009 May.
[Is] ISSN:1466-5026
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two novel yeast species, Wickerhamomyces queroliae sp. nov. and Candida jalapaonensis sp. nov., were isolated, respectively, from larvae of Anastrepha mucronata (Diptera: Tephritidae) collected from ripe fruit of Peritassa campestris ('Bacupari', Hippocrateaceae) and from flowers of Centropogon cornutus (Campanulaceae) in the Cerrado ecosystem of the state of Tocantins, Brazil. Analysis of the D1/D2 large-subunit rRNA gene sequences placed W. queroliae in the Wickerhamomyces clade near Wickerhamomyces ciferri and Candida silvicultrix. Candida jalapaonensis belongs to the Wickerhamiella clade and is related to Candida drosophilae. The type strain of Wickerhamomyces queroliae is UFMG-05-T200.1(T) (=CBS 10936(T)=NRRL Y-48478(T)) and the type strain of Candida jalapaonensis is UFMG-03-T210(T) (=CBS 10935(T)=NRRL Y-48477(T)).
[Mh] Termos MeSH primário: Campanulaceae/microbiologia
Candida/classificação
Ecossistema
Saccharomycetales/classificação
Tephritidae/microbiologia
[Mh] Termos MeSH secundário: Animais
Brasil
Candida/genética
Candida/isolamento & purificação
DNA Fúngico/análise
DNA Fúngico/isolamento & purificação
Flores/microbiologia
Frutas/parasitologia
Hippocrateaceae/parasitologia
Larva/microbiologia
Dados de Sequência Molecular
Técnicas de Tipagem Micológica
Filogenia
RNA Ribossômico 16S/genética
Saccharomycetales/genética
Saccharomycetales/isolamento & purificação
Análise de Sequência de DNA
Especificidade da Espécie
Tephritidae/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Fungal); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:0907
[Cu] Atualização por classe:090501
[Lr] Data última revisão:
090501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090502
[St] Status:MEDLINE
[do] DOI:10.1099/ijs.0.006411-0


  6 / 16 MEDLINE  
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[PMID]:19261704
[Au] Autor:Shirvalkar PR
[Ad] Endereço:Fishberg Department of Neuroscience, Mount Sinai Medical Center, 1425 Madison Ave., Room 9-23, New York, NY 10029, USA. Prasad.Shirvalkar@mssm.edu
[Ti] Título:Hippocampal neural assemblies and conscious remembering.
[So] Source:J Neurophysiol;101(5):2197-200, 2009 May.
[Is] ISSN:0022-3077
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hippocampal formation is needed to encode episodic memories, which may be consciously recalled at some future time. This review examines recent advances in understanding recollection in the context of spatiotemporally organized relational memory coding and discusses predictions and challenges for future research on conscious remembering.
[Mh] Termos MeSH primário: Estado de Consciência/fisiologia
Hippocrateaceae/citologia
Memória/fisiologia
Neurônios/fisiologia
[Mh] Termos MeSH secundário: Animais
Hippocrateaceae/fisiologia
Seres Humanos
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:0906
[Cu] Atualização por classe:090421
[Lr] Data última revisão:
090421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090306
[St] Status:MEDLINE
[do] DOI:10.1152/jn.91363.2008


  7 / 16 MEDLINE  
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[PMID]:19048315
[Au] Autor:Setzer WN
[Ad] Endereço:Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA. wsetzer@chemistry.uah.edu
[Ti] Título:A theoretical investigation of cytotoxic activity of celastroid triterpenoids.
[So] Source:J Mol Model;15(2):197-201, 2009 Feb.
[Is] ISSN:0948-5023
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Quantum chemical calculations at the B3LYP/6-31G* level of theory have been carried out on 20 celastroid triterpenoids to obtain a set of molecular electronic properties and to correlate these with cytotoxic activities. The cytotoxic activities of these compounds can be roughly correlated with electronic effects related to nucleophilic addition to C6 of the compounds: the energies of the frontier molecular orbitals (E(HOMO) and E(LUMO)), the HOMO-LUMO energy gap, the dipole moment, the charge on C6, and the electrophilicity on C6.
[Mh] Termos MeSH primário: Citotoxinas/química
Modelos Químicos
Modelos Moleculares
Triterpenos/química
[Mh] Termos MeSH secundário: Celastraceae/química
Citotoxinas/farmacologia
Elétrons
Hippocrateaceae/química
Estrutura Molecular
Relação Estrutura-Atividade
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Triterpenes)
[Em] Mês de entrada:0901
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081203
[St] Status:MEDLINE
[do] DOI:10.1007/s00894-008-0394-9


  8 / 16 MEDLINE  
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Albuquerque, Sérgio
[PMID]:18533463
[Au] Autor:Lião LM; Silva GA; Monteiro MR; Albuquerque S
[Ad] Endereço:Instituto de Química, Universidade Federal de Goiás, Campus Samambaia, C. P. 131, 74001-970 Goiânia, GO, Brazil. luciano@quimica.ufg.br
[Ti] Título:Trypanocidal activity of quinonemethide triterpenoids from Cheiloclinium cognatum (Hippocrateaceae).
[So] Source:Z Naturforsch C;63(3-4):207-10, 2008 Mar-Apr.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We report the trypanocidal activity of quinonemethide triterpenoids isolated from root extracts of Cheiloclinium cognatum, a plant of the Hippocrateaceae family, collected in the Cerrado Reserve at Universidade Federal de Goiás, Brazil. The trypanocidal activity assays showed an effect on the blood trypomastigote forms of the Y strain of Trypanosoma cruzi where tingenone and tingenol demonstrated activity on the parasite. Their structures were elucidated on the basis of spectral data, particularly COSY, HMQC and HMBC experiments, and chemical transformations.
[Mh] Termos MeSH primário: Hippocrateaceae/química
Raízes de Plantas/química
Caules de Planta/química
Quinonas/química
Triterpenos/química
Tripanossomicidas/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Conformação Molecular
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Quinonas/isolamento & purificação
Quinonas/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
Tripanossomicidas/isolamento & purificação
Tripanossomicidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Quinones); 0 (Triterpenes); 0 (Trypanocidal Agents); 0 (tingenol)
[Em] Mês de entrada:0808
[Cu] Atualização por classe:091104
[Lr] Data última revisão:
091104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080607
[St] Status:MEDLINE


  9 / 16 MEDLINE  
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[PMID]:18061220
[Au] Autor:Cáceres-Castillo D; Mena-Rejón GJ; Cedillo-Rivera R; Quijano L
[Ad] Endereço:Laboratorio de Química Orgánica de Investigación, Facultad de Química, Universidad Autónoma de Yucatán, Calle 41 No. 421, Col. Industrial, C.P. 97150 Mérida, Yucatán, México.
[Ti] Título:21beta-Hydroxy-oleanane-type triterpenes from Hippocratea excelsa.
[So] Source:Phytochemistry;69(4):1057-64, 2008 Feb.
[Is] ISSN:0031-9422
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Stem bark of Hippocratea excelsa afforded six pentacyclic triterpenes, five oleanane and one ursane types. They were identified as 11beta,21beta-dihydroxy-olean-12-ene-3-one (2), 3alpha,11alpha,21beta-trihydroxy-olean-12-ene (3), 3alpha,21beta-dihydroxy-11alpha-methoxy-olean-12-ene (4), 3alpha,21beta-dihydroxy-olean-9(11),12-diene (5), 3alpha,21beta-dihydroxy-olean-12-ene (6) and 3alpha,21beta-dihydroxy-11alpha-methoxy-urs-12-ene, isolated as its diacetate derivative (7), as well as 3alpha,21beta-dihydroxy-olean-12-ene (1) previously isolated from the root bark. The known alpha- and beta-amyrin, oleanoic and ursolic acids, trans-polyisoprene, and the ubiquitous beta-sitosterol were also isolated. Structures were elucidated on the basis of spectroscopic analyses, including homo- and heteronuclear correlation NMR experiments (COSY, ROESY, HSQC and HMBC) and comparison with literature data. The antigiardial activity of compounds 2-5 was not significant.
[Mh] Termos MeSH primário: Hippocrateaceae/química
Ácido Oleanólico/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Estrutura Molecular
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/isolamento & purificação
Triterpenos Pentacíclicos/química
Triterpenos Pentacíclicos/isolamento & purificação
Casca de Planta/química
Triterpenos/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pentacyclic Triterpenes); 0 (Triterpenes); 6SMK8R7TGJ (Oleanolic Acid); KM8353IPSO (amyrin); P3M2575F3F (ursolic acid)
[Em] Mês de entrada:0807
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071207
[St] Status:MEDLINE


  10 / 16 MEDLINE  
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[PMID]:17385912
[Au] Autor:Mena-Rejón GJ; Pérez-Espadas AR; Moo-Puc RE; Cedillo-Rivera R; Bazzocchi IL; Jiménez-Diaz IA; Quijano L
[Ad] Endereço:Laboratorio de Química OrgAnica de Investigación, Facultad de Química, Universidad Autónoma de YucatAn, Calle 41 No. 421, Col. Industrial, C. P. 97105, Mérida, YucatAn, México. quijano@servidor.unam.mx
[Ti] Título:Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa.
[So] Source:J Nat Prod;70(5):863-5, 2007 May.
[Is] ISSN:0163-3864
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two new triterpenoids, 21 beta-hydroxyolean-12-en-3-one (1) and a seco-dinor derivative of pristimerine named dzununcanone (2), were isolated from the root bark of Hippocratea excelsa. Their structures were assigned on the basis of spectroscopic evidence, mainly 1H and 13C 1D and 2D NMR including DEPT, COSY, ROESY, HSQC, and HMBC experiments, as well as EIMS and HREIMS. The known 21alpha-hydroxy-3-oxofriedelane (3), a compound new to the species, and the known methide quinones pristimerine (4) tingenone (5), and xuxuarine Ebeta (7) were also isolated. The antiprotozoal activities were determined against Giardia intestinalis. Pristimerine and tingenone were the most active antigiardial compounds, with IC50 values of 0.11 and 0.74 microM, respectively, compared with metronidazole, the current drug of choice (IC50 1.23 microM).
[Mh] Termos MeSH primário: Antiprotozoários/isolamento & purificação
Antiprotozoários/farmacologia
Giardia lamblia/efeitos dos fármacos
Hippocrateaceae/química
Plantas Medicinais/química
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/química
México
Estrutura Molecular
Raízes de Plantas/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (21 beta-hydroxyolean-12-en-3-one); 0 (Antiprotozoal Agents); 0 (Triterpenes); 0 (dzununcanone)
[Em] Mês de entrada:0707
[Cu] Atualização por classe:070525
[Lr] Data última revisão:
070525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070328
[St] Status:MEDLINE



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