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Pesquisa : B01.650.940.800.575.912.250.572 [Categoria DeCS]
Referências encontradas : 19 [refinar]
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  1 / 19 MEDLINE  
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[PMID]:25476830
[Au] Autor:Alonso-Castro AJ; Zavala-Sánchez MA; Pérez-Ramos J; Sánchez-Mendoza E; Pérez-Gutiérrez S
[Ad] Endereço:Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana - Xochimilco, Mexico.
[Ti] Título:Antinociceptive and anti-arthritic effects of kramecyne.
[So] Source:Life Sci;121:70-7, 2015 Jan 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: The aim of this study was to evaluate the antinociceptive (acute assays) and anti-inflammatory (chronic assays) effects of kramecyne (KACY), a peroxide isolated from Krameria cytisoides. MAIN METHODS: The antinociceptive activity of KACY was evaluated using the hot plate, acetic acid and formalin tests. The effects of KACY on heat-induced hemolysis in rat erythrocytes were also evaluated. The in vivo anti-inflammatory assays were performed using the chronic TPA (12-O-tetradecanoylphorbol 13-acetate) method to induce ear edema and carrageenan-kaolin induced arthritis (CKIA). In the CKIA model, the hot plate test was performed, serum samples were obtained for the quantitation of pro-inflammatory (IL-1ß, IL-6, IL-12 and TNF-α) and anti-inflammatory (IL-4 and IL-10) cytokines. KEY FINDINGS: KACY possess antinociceptive effects with comparable activity to naproxen (NPX). KACY inhibited hemolysis (EC50 = 180 µg/mL), in comparison to the untreated group and with a higher potency than NPX (EC50 = 263 µg/mL). KACY at 50 mg/kg decreased inflammation by 38% (chronic TPA-induced edema model) and by 26% (CKIA model), in comparison with the vehicle group and with similar activity to the positive controls 8 mg/kg indomethacin (IND) and 1 mg/kg methotrexate (MTX), respectively. In the CKIA model, KACY increased the release of anti-inflammatory (IL-4 and IL-10) cytokines but reduced the production of pro-inflammatory cytokines (IL-1ß, IL-6, IL-12 and TNF-α). KACY at 50 and 100 mg/kg showed antinociceptive effects by 27% and 23%, respectively, in mice with mono-arthritis. SIGNIFICANCE: KACY might be a good alternative for the treatment of rheumatoid arthritis (RA) due its antinociceptive and anti-inflammatory activities.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Artrite/tratamento farmacológico
Éteres Cíclicos/uso terapêutico
Peróxidos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Artrite/induzido quimicamente
Peso Corporal/efeitos dos fármacos
Citocinas/metabolismo
Edema/induzido quimicamente
Edema/tratamento farmacológico
Membrana Eritrocítica/efeitos dos fármacos
Hemólise/efeitos dos fármacos
Técnicas In Vitro
Krameriaceae/química
Masculino
Camundongos
Medição da Dor/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 0 (Ethers, Cyclic); 0 (Peroxides); 0 (kramecyne)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:150128
[Lr] Data última revisão:
150128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141206
[St] Status:MEDLINE


  2 / 19 MEDLINE  
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[PMID]:23305162
[Au] Autor:Jiménez-Estrada M; Velázquez-Contreras C; Garibay-Escobar A; Sierras-Canchola D; Lapizco-Vázquez R; Ortiz-Sandoval C; Burgos-Hernández A; Robles-Zepeda RE
[Ad] Endereço:Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, México, Distrito Federal 04510, México.
[Ti] Título:In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico.
[So] Source:BMC Complement Altern Med;13:12, 2013 Jan 10.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study, is to investigate the in vitro antioxidant activity, the total phenols content, the flavonoids content and the antiproliferative activity of methanolic extracts of the plants: Krameria erecta, Struthanthus palmeri, Phoradendron californicum, Senna covesii and Stegnosperma halimifolium, used by different ethnic groups from northwestern Mexico in the treatment and cure of various diseases. METHODS: The in vitro antioxidant activity was measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric Reducing/Antioxidant Power assay (FRAP), the total phenols content was measured by Folin-Ciocalteau assay, the flavonoids content by the AlCl(3) colorimetric method and the antiproliferative activity (line cells HeLa, RAW 264.7, M12A(k).C3.F6 and L929) using MTT method. RESULTS: The K. erecta extract showed the higher radical scavenging activity (67.88%), antioxidant activity by FRAP (1.41 mg Trolox Eq), the highest total phenols content (598.51 mg Galic Acid Eq/g extract), the highest flavonoids content (3.80 mg Quercetin Eq/g extract) and the greatest antiproliferative activity in a dose dependent manner against most Cell line evaluated. A positive correlation was found between the antioxidant activity and the flavonoids content. CONCLUSIONS: This study is the first report on the antioxidant and antiproliferative activities of the five species evaluated. The results demostrate that there is a positive correlation between antioxidant activity and the flavonoids content, indicating that these type of polyphenols could be the major contributors to the observed antioxidant activity in the evaluated plant extracts. Of the extracts evaluated, that of Krameria erecta showed the greatest antioxidant and antiproliferative activities, a discovery that makes this species a promising candidate for future research.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Antioxidantes/uso terapêutico
Krameriaceae/química
Magnoliopsida/química
Neoplasias/terapia
Fitoterapia
Polifenóis/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Linhagem Celular
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Etnofarmacologia
Flavonoides/farmacologia
Flavonoides/uso terapêutico
Células HeLa
Seres Humanos
Loranthaceae/química
México
Camundongos
Fenóis/farmacologia
Fenóis/uso terapêutico
Phoradendron/química
Phytolaccaceae/química
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Polifenóis/farmacologia
Senna (Planta)/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Polyphenols)
[Em] Mês de entrada:1306
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130112
[St] Status:MEDLINE
[do] DOI:10.1186/1472-6882-13-12


  3 / 19 MEDLINE  
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[PMID]:23161426
[Au] Autor:Ramírez-Cisneros MA; Rios MY; Ríos-Gómez R; Aguilar-Guadarrama AB
[Ad] Endereço:Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
[Ti] Título:Cycloartanes from Krameria pauciflora and their in vitro PLA2, COX-1, and COX-2 enzyme inhibitory activities.
[So] Source:Planta Med;78(18):1942-8, 2012 Dec.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Krameria pauciflora is a species belonging to the Krameriaceae family. It has been used to treat inflammatory disorders in folkloric Mexican medicine; however, chemistry and pharmacological studies have not been carried out on this species. In this work, from the dichloromethane root extract of K. pauciflora, five cycloartane-type triterpenoids were isolated: cyclomargenyl-3-O-ß-caffeoyl ester (1), cyclomargenyl-3-O-ß-feruloyl ester (2), cyclomargenyl-3-O-ß-coumaroyl ester (3), cyclomargenol (4, polysthicol), and cyclomargenone (5). Additionally, the lignane 6'-methoxyrataniaphenol was isolated. To the best of our knowledge, compounds 1-3 are new natural products, whereas compounds 4 and 5 are isolated for the first time in the Krameria genus and the Krameriaceae family. The structures of all of these compounds were established by 1D and 2D NMR spectroscopy including ¹H, ¹³C, DEPT, COSY, HSQC, and HMBC experiments, as well as by EI mass spectrometry. There is an incomplete previous report about the spectroscopic data of compounds 4 and 5. However, in this work, a complete and unambiguous assignation has been realized. Due to the traditional use of this plant and other species from this genus, such as K. lappacea, cycloartanes isolated herein were evaluated by their inhibition of phospholipase A2, cyclooxygenase-1, and cyclooxygenase-2 enzymes. Cyclomargenyl-3-O-ß-caffeoyl ester (1) showed inhibition of phospholipase A2, cyclooxygenase-1, and cyclooxygenase-2 target enzymes for nonsteroidal anti-inflammatory drugs. Both cyclooxygenases were inhibited by cyclomargenol (4); however, cyclomargenyl-3-O-ß-feruloyl ester (2) showed inhibition only on cyclooxygenase-1.
[Mh] Termos MeSH primário: Ácidos Cafeicos/isolamento & purificação
Ácidos Cafeicos/farmacologia
Inibidores de Ciclo-Oxigenase/farmacologia
Krameriaceae/química
Inibidores de Fosfolipase A2
Extratos Vegetais/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Ácidos Cafeicos/química
Inibidores de Ciclo-Oxigenase 2/química
Inibidores de Ciclo-Oxigenase 2/farmacologia
Inibidores de Ciclo-Oxigenase/química
Medicina Tradicional
México
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Raízes de Plantas/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Caffeic Acids); 0 (Cyclooxygenase 2 Inhibitors); 0 (Cyclooxygenase Inhibitors); 0 (Phospholipase A2 Inhibitors); 0 (Plant Extracts); 0 (Triterpenes); 0 (cyclomargenol); 0 (cyclomargenyl-3-O-beta-caffeoyl ester); 0 (cyclomargenyl-3-O-beta-feruloyl ester)
[Em] Mês de entrada:1306
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121120
[St] Status:MEDLINE
[do] DOI:10.1055/s-0032-1327882


  4 / 19 MEDLINE  
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[PMID]:22771373
[Au] Autor:Ladurner A; Atanasov AG; Heiss EH; Baumgartner L; Schwaiger S; Rollinger JM; Stuppner H; Dirsch VM
[Ad] Endereço:Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria. angela.ladurner@univie.ac.at
[Ti] Título:2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells.
[So] Source:Biochem Pharmacol;84(6):804-12, 2012 Sep 15.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Endothelial nitric oxide synthase (eNOS) mediates important vaso-protective and immunomodulatory effects. Aim of this study was to examine whether lignan derivatives isolated from the roots of the anti-inflammatory medicinal plant Krameria lappacea influence eNOS activity and endothelial nitric oxide (NO) release. The study was performed using cultured human umbilical vein endothelial cells (HUVECs) and HUVEC-derived EA.hy926 cells. Among the eleven isolated compounds only 2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran (DPPB) was able to increase eNOS enzyme activity. DPPB (1-10 µM) treatment for 24 h induced a significant and dose-dependent increase in eNOS activity as determined by the [(14)C]L-arginine/[(14)C]L-citrulline conversion assay. Immunoblotting studies further revealed a time-dependent DPPB-induced increase in eNOS-Ser(1177) and decrease in eNOS-Thr(495) phosphorylation, as well as increased AMPK phosphorylation at Thr(172), whereas Akt phosphorylation at Ser(473) was not affected. Si-RNA-mediated knockdown of AMPK and inhibition of CaMKKß by STO 609, as well as intracellular Ca(2+) chelation by Bapta AM abolished the stimulating effect of DPPB on eNOS-Ser(1177) and AMPK-Thr(172) phosphorylation. Furthermore, we could show that DPPB increases intracellular Ca(2+) concentrations assessed with the fluorescent dye Fluo-3-AM. DPPB enhances eNOS activity and endothelial NO release by raising intracellular Ca(2+) levels and increases signaling through a CaMKKß-AMPK dependent pathway.
[Mh] Termos MeSH primário: Furanos/farmacologia
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Óxido Nítrico Sintase Tipo III/metabolismo
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/metabolismo
Cálcio/metabolismo
Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina/metabolismo
Quelantes/farmacologia
Furanos/química
Furanos/isolamento & purificação
Células Endoteliais da Veia Umbilical Humana/metabolismo
Seres Humanos
Espaço Intracelular/metabolismo
Krameriaceae
Lignanas/química
Lignanas/isolamento & purificação
Lignanas/farmacologia
Óxido Nítrico/metabolismo
Fosforilação
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2-(2,4-dihydroxyphenyl)-5-propenylbenzofuran); 0 (Chelating Agents); 0 (Furans); 0 (Lignans); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type III); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Kinase); EC 2.7.11.31 (AMP-Activated Protein Kinases); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1210
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120710
[St] Status:MEDLINE
[do] DOI:10.1016/j.bcp.2012.06.029


  5 / 19 MEDLINE  
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[PMID]:22349895
[Au] Autor:Pérez-Gutiérrez S; Sánchez-Mendoza E; Martínez-González D; Zavala-Sánchez MA; Pérez-González C
[Ad] Endereço:Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoacan C.P. 04960, D.F.A.P. 23-181, Mexico.
[Ti] Título:Kramecyne--a new anti-inflammatory compound isolated from Krameria cytisoides.
[So] Source:Molecules;17(2):2049-57, 2012 Feb 20.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the present work we describe the structure and anti-inflammatory activity of a new compound, kramecyne, isolated from a methanol extract of Krameria cytisoides (Krameriaceae). The structure of kramecyne was determined by IR, NMR, MS, and elemental analysis, which indicated that the structure corresponded to a hexamer of cyclic peroxide monomers. This compound exhibited good anti-inflammatory activity in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema (51.8 ± 6.9% inhibition) and carrageenan-induced rat paw edema models at doses of 50 mg/kg. The compound significantly reduced edema to 63.1% after 1.0 h, and the effect was unchanged for 5 h. Kramecyne did not present acute toxicity, even at doses of 5,000 mg/kg.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Éteres Cíclicos/química
Éteres Cíclicos/farmacologia
Krameriaceae/química
Peróxidos/química
Peróxidos/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Edema/induzido quimicamente
Edema/tratamento farmacológico
Masculino
Camundongos
Ratos
Ratos Wistar
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Ethers, Cyclic); 0 (Peroxides); 0 (Plant Extracts); 0 (kramecyne)
[Em] Mês de entrada:1210
[Cu] Atualização por classe:150401
[Lr] Data última revisão:
150401
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120222
[St] Status:MEDLINE
[do] DOI:10.3390/molecules17022049


  6 / 19 MEDLINE  
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[PMID]:22307937
[Au] Autor:Heiss EH; Baumgartner L; Schwaiger S; Heredia RJ; Atanasov AG; Rollinger JM; Stuppner H; Dirsch VM
[Ad] Endereço:Department of Pharmacognosy, University of Vienna, Vienna, Austria.
[Ti] Título:Ratanhiaphenol III from Ratanhiae radix is a PTP1B inhibitor.
[So] Source:Planta Med;78(7):678-81, 2012 May.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The inhibition of protein tyrosine phosphatase 1B (PTP1B) is considered a valid strategy to combat insulin resistance and type II diabetes. We show here that a dichloromethane extract of Ratanhiae radix ( RR_EX) dose-dependently inhibits human recombinant PTP1B in vitro and enhances insulin-stimulated glucose uptake in murine myocytes. By determination of the PTP1B inhibiting potential of 11 recently isolated lignan derivatives from RR_EX, the observed activity of the extract could be partly assigned to ratanhiaphenol III. This compound inhibited PTP1B in vitro with an IC (50) of 20.2 µM and dose-dependently increased insulin receptor phosphorylation as well as insulin-stimulated glucose uptake in cultured myotubes. This is the first report to reveal an antidiabetic potential for a constituent of rhatany root, traditionally used against inflammatory disorders, by showing its capability of inhibiting PTP1B.
[Mh] Termos MeSH primário: Benzofuranos/farmacologia
Diabetes Mellitus Tipo 2/tratamento farmacológico
Krameriaceae/química
Lignanas/farmacologia
Síndrome Metabólica/tratamento farmacológico
Fitoterapia
Preparações de Plantas/farmacologia
Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Tipo 2/metabolismo
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/farmacologia
Glucose/metabolismo
Seres Humanos
Hipoglicemiantes/farmacologia
Resistência à Insulina
Lignanas/uso terapêutico
Síndrome Metabólica/metabolismo
Camundongos
Células Musculares/metabolismo
Fibras Musculares Esqueléticas/metabolismo
Raízes de Plantas/química
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzofurans); 0 (Enzyme Inhibitors); 0 (Hypoglycemic Agents); 0 (Lignans); 0 (Plant Preparations); 0 (ratanhiaphenol III); EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1210
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120207
[St] Status:MEDLINE
[do] DOI:10.1055/s-0031-1298242


  7 / 19 MEDLINE  
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[PMID]:22252502
[Au] Autor:Ramírez-Cisneros MÁ; Rios MY; Déciga-Campos M; Aguilar-Guadarrama AB
[Ad] Endereço:Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad No. 1001 Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico. angelesrc@uaem.mx
[Ti] Título:Phytochemical study and anti-inflammatory, antidiabetic and free radical scavenger evaluations of Krameria pauciflora methanol extract.
[So] Source:Molecules;17(1):861-72, 2012 Jan 17.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The plant Krameria pauciflora MOC et. Sessé ex DC. is used as an anti-inflammatory and antidiabetic in traditional medicine. The aim of this study was to evaluate the in vivo anti-inflammatory and antidiabetic effects of a methanol extract from the roots of K. pauciflora. Dichloromethane and ethyl acetate extracts obtained by partitioning the methanol extract were also evaluated. Complete methanol and dichloromethane extracts showed anti-inflammatory effects at 3 mg/kg. An anti-inflammatory effect similar to indomethacin (10 mg/kg) was observed when the methanol and dichloromethane extracts, which contain a cycloartane-type triterpene and an sterol, were administered orally at several doses (3, 10, 30 and 100 mg/kg), whereas no anti-inflammatory effect was observed at any dose for the ethyl acetate extract, which contains catechin-type flavonoids. The antidiabetic effect of each extract was also determined. An antihyperglycaemic effect was observed in diabetic rats, but no effect in normoglycaemic animals was observed when the methanol extract was administrated at 30 mg/kg. All of the extracts exhibited radical scavenger activity. Additionally, constituents from all of the extracts were identified by NMR. This article supports the use of K. pauciflora as an anti-inflammatory because it exhibits a similar effect to indomethacin. However, its antidiabetic effect is not completely clear, although it could be useful for preventing diabetic complications.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Depuradores de Radicais Livres/isolamento & purificação
Hipoglicemiantes/isolamento & purificação
Krameriaceae/química
Metanol/química
Extratos Vegetais/isolamento & purificação
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Área Sob a Curva
Benzotiazóis/química
Compostos de Bifenilo/química
Glicemia
Carragenina
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/tratamento farmacológico
Edema/induzido quimicamente
Edema/tratamento farmacológico
/patologia
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/farmacologia
Radicais Livres/química
Hipoglicemiantes/química
Hipoglicemiantes/farmacologia
Masculino
Picratos/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
Ácidos Sulfônicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Blood Glucose); 0 (Free Radical Scavengers); 0 (Free Radicals); 0 (Hypoglycemic Agents); 0 (Picrates); 0 (Plant Extracts); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); 9000-07-1 (Carrageenan); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120119
[St] Status:MEDLINE
[do] DOI:10.3390/molecules17010861


  8 / 19 MEDLINE  
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[PMID]:22182580
[Au] Autor:Artini M; Papa R; Barbato G; Scoarughi GL; Cellini A; Morazzoni P; Bombardelli E; Selan L
[Ad] Endereço:Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.
[Ti] Título:Bacterial biofilm formation inhibitory activity revealed for plant derived natural compounds.
[So] Source:Bioorg Med Chem;20(2):920-6, 2012 Jan 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Use of herbal plant remedies to treat infectious diseases is a common practice in many countries in traditional and alternative medicine. However to date there are only few antimicrobial agents derived from botanics. Based on microbiological screening tests of crude plant extracts we identified four compounds derived from Krameria, Aesculus hippocastanum and Chelidonium majus that showed a potentially interesting antimicrobial activity. In this work we present an in depth characterization of the inhibition activity of these pure compounds on the formation of biofilm of Staphylococcus aureus as well as of Staphylococcus epidermidis strains. We show that two of these compounds possess interesting potential to become active principles of new drugs.
[Mh] Termos MeSH primário: Antibacterianos/química
Biofilmes/efeitos dos fármacos
Produtos Biológicos/química
Extratos Vegetais/farmacologia
Plantas/química
Staphylococcus aureus/fisiologia
Staphylococcus epidermidis/fisiologia
[Mh] Termos MeSH secundário: Aesculus/química
Antibacterianos/farmacologia
Produtos Biológicos/farmacologia
Chelidonium/química
Krameriaceae/química
Proteínas de Membrana/antagonistas & inibidores
Proteínas de Membrana/metabolismo
Testes de Sensibilidade Microbiana
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Biological Products); 0 (Membrane Proteins); 0 (Plant Extracts)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111221
[St] Status:MEDLINE
[do] DOI:10.1016/j.bmc.2011.11.052


  9 / 19 MEDLINE  
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[PMID]:21800856
[Au] Autor:Baumgartner L; Sosa S; Atanasov AG; Bodensieck A; Fakhrudin N; Bauer J; Favero GD; Ponti C; Heiss EH; Schwaiger S; Ladurner A; Widowitz U; Loggia RD; Rollinger JM; Werz O; Bauer R; Dirsch VM; Tubaro A; Stuppner H
[Ad] Endereço:Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Josef-Moeller-Haus, Innrain 52c, 6020 Innsbruck, Austria.
[Ti] Título:Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
[So] Source:J Nat Prod;74(8):1779-86, 2011 Aug 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The roots of Krameria lappacea are used traditionally against oropharyngeal inflammation. So far, the astringent and antimicrobial properties of its proanthocyanidin constituents are considered to account for the anti-inflammatory effect. The aim of the present study was to characterize pharmacologically a lipophilic extract of K. lappacea roots and several isolated lignan derivatives (1-11) in terms of their putative anti-inflammatory activity. The dichloromethane extract (ID50 77 µg/cm²) as well compounds 1-11 (ID50 0.31-0.60 µmol/cm²) exhibited topical antiedematous properties comparable to those of indomethacin (ID50 0.29 µmol/cm²) in a mouse ear in vivo model. Two of the most potent compounds, 2-(2-hydroxy-4-methoxyphenyl)-5-(3-hydroxypropyl)benzofuran (5) and (+)-conocarpan (7), were studied regarding their time-dependent edema development and leukocyte infiltration up to 48 h after croton oil-induced dermatitis induction, and they showed activity profiles similar to that of hydrocortisone. In vitro studies of the isolated lignan derivatives demonstrated the inhibition of NF-κB, cyclooxygenase-1 and -2, 5-lipoxygenase, and microsomal prostaglandin E2 synthase-1 as well as antioxidant properties, as mechanisms possibly contributing to the observed in vivo effects. The present findings not only support the ethnopharmacological use of K. lappacea roots but also reveal that the isolated lignan derivatives contribute strongly to the anti-inflammatory activity of this herbal drug.
[Mh] Termos MeSH primário: Benzofuranos/isolamento & purificação
Benzofuranos/farmacologia
Krameriaceae/química
Lignanas/isolamento & purificação
Lignanas/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/sangue
Anti-Inflamatórios não Esteroides/farmacologia
Anti-Inflamatórios não Esteroides/uso terapêutico
Araquidonato 5-Lipoxigenase/efeitos dos fármacos
Áustria
Benzofuranos/química
Ciclo-Oxigenase 1/efeitos dos fármacos
Edema/induzido quimicamente
Edema/tratamento farmacológico
Oxirredutases Intramoleculares/antagonistas & inibidores
Lignanas/sangue
Lignanas/química
Masculino
Camundongos
NF-kappa B/efeitos dos fármacos
Raízes de Plantas/química
Prostaglandina-E Sintases
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2-(2-hydroxy-4-methoxyphenyl)-5-(3-hydroxypropyl)benzofuran); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Benzofurans); 0 (Lignans); 0 (NF-kappa B); 30358-74-8 (conocarpan); EC 1.13.11.34 (Arachidonate 5-Lipoxygenase); EC 1.14.99.1 (Cyclooxygenase 1); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.99.3 (Prostaglandin-E Synthases)
[Em] Mês de entrada:1111
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110802
[St] Status:MEDLINE
[do] DOI:10.1021/np200343t


  10 / 19 MEDLINE  
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[PMID]:21783335
[Au] Autor:Baumgartner L; Schwaiger S; Stuppner H
[Ad] Endereço:Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria.
[Ti] Título:Quantitative analysis of anti-inflammatory lignan derivatives in Ratanhiae radix and its tincture by HPLC-PDA and HPLC-MS.
[So] Source:J Pharm Biomed Anal;56(3):546-52, 2011 Nov 01.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Root preparations of Krameria lappacea (Dombey) Burdet et Simpson are traditionally used against oropharyngeal inflammation. Besides antimicrobial and astringent procyanidines, lignan derivatives, including ratanhiaphenol I, II, III and (+)-conocarpan, contribute to the activity of Ratanhiae radix, exerting a significant topical anti-inflammatory activity in vivo, and in vitro by inhibiting NF-κB and the formation of inflammatory prostaglandins and leukotrienes. Besides gravimetrical analysis of the ratanhiaphenols I, II and III, the content of these compounds in the herbal drug has never been determined. The developed HPLC method enables the quantification of twelve active lignan derivatives in the roots, and is also suitable for the determination of the constituents in Tinctura Ratanhiae. Separation was achieved on a phenyl-hexyl column material using a solvent gradient consisting of 0.02% aqueous TFA and a mixture of acetonitrile/methanol (75:25, v/v). Sensitivity, accuracy (recovery rates were between 95% and 105.6%), repeatability (RSD ≤ 4.6%), and precision (intra-day precision ≤ 4.8%; inter-day precision ≤ 3.4%) of the method were determined. HPLC-MS experiments in positive and negative electrospray ionization mode confirmed identity and peak purity of analytes. The analysis of several root and tincture samples revealed that (+)-conocarpan and ratanhiaphenol II dominated with contents of 0.49-0.71% and 0.51-0.53% in the roots and 0.66-0.68 mg/ml and 0.70-0.71 mg/ml in the commercial tinctures, respectively.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Cromatografia Líquida de Alta Pressão/métodos
Krameriaceae/química
Lignanas/química
Espectrometria de Massas por Ionização por Electrospray/métodos
[Mh] Termos MeSH secundário: Preparações de Plantas/química
Raízes de Plantas/química
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lignans); 0 (Plant Preparations)
[Em] Mês de entrada:1202
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110726
[St] Status:MEDLINE
[do] DOI:10.1016/j.jpba.2011.06.016



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