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Pesquisa : B01.650.940.800.575.912.250.583.080 [Categoria DeCS]
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[PMID]:28787158
[Au] Autor:Kil YS; Kim SM; Kang U; Chung HY; Seo EK
[Ad] Endereço:College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University , Seoul 03760, Korea.
[Ti] Título:Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata.
[So] Source:J Nat Prod;80(8):2240-2251, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6'-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7'S,8'R)-lariciresinol 9'-O-ß-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO ) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC values in the range 0.14-2.2 µM.
[Mh] Termos MeSH primário: Bignoniaceae/química
Furanos/química
Furanos/isolamento & purificação
Glucosídeos/química
Glucosídeos/isolamento & purificação
Glicosídeos/química
Glicosídeos/isolamento & purificação
Glucosídeos Iridoides/química
Glucosídeos Iridoides/isolamento & purificação
Iridoides/química
Iridoides/isolamento & purificação
Lignanas/química
Lignanas/isolamento & purificação
Ácido Peroxinitroso/química
Ácido Peroxinitroso/isolamento & purificação
[Mh] Termos MeSH secundário: Concentração Inibidora 50
Estrutura Molecular
Caules de Planta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3,4-dihydro-6-O-di-trans-feruloyl catalpol); 0 (6,10-O-di-trans-feruloyl catalpol); 0 (6-O-veratroyl catalpol); 0 (Furans); 0 (Glucosides); 0 (Glycosides); 0 (Iridoid Glucosides); 0 (Iridoids); 0 (Lignans); 14691-52-2 (Peroxynitrous Acid); 2415-24-9 (catalpol); 73XCE5OZB0 (lariciresinol); 7KD7K3964H (catalposide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00139


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[PMID]:28391450
[Au] Autor:Pereira SG; de Araújo SA; Guilhon GMSP; Santos LS; Junior LMC
[Ad] Endereço:Universidade Federal do Maranhão - Centro de Ciências Agrárias e Ambientais - Campus IV, MA 230, km 04, bairro Boa Vista, Chapadinha, Maranhão, CEP 65500-000, Brazil. sinval@ufma.br.
[Ti] Título:In vitro acaricidal activity of Crescentia cujete L. fruit pulp against Rhipicephalus microplus.
[So] Source:Parasitol Res;116(5):1487-1493, 2017 May.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cattle tick (Rhipicephalus microplus) is an important constraint on livestock production, particularly in tropical and subtropical areas. Synthetic acaricides are the primary method of control this thick. Resistance of R. microplus to synthetic acaricides has given rise to the need of new scientific investigations on alternative ways to control it. The objective of this work was to conduct a chemical investigation of Crescentia cujete L. fruit pulp and to evaluate the acaricide effect on R. microplus larvae of extracts, fractions, and isolated substances from this species. Crescentia cujete is a Bignoniaceae and it is characteristic of tropical climates. Its most distinctive feature is its fruit, which is spherical and gourd-like, with a hard woody shell and gelatinous pulp. The fruit pulp of C. cujete was extracted with ethanol by maceration yielding an extract and a residue. The extract was partitioned giving an ethyl acetate phase (EAF) that was fractionated by chromatographic procedures yielding cinnamic acid and benzoic acid. The remained botanic material from the ethanol extraction was further and successively extracted with ethyl ether and methanol under reflux. The acaricide effect of all extracts and fractions was evaluated against R. microplus using the larval packet test. The best result was observed for the EAF that caused 100% of mortality when a 10% solution was used and with LC of 5.9%. Cinnamic acid was also tested showing 63.0% of mortality with LC of 6.6% at the same concentrations and time of the experiment. The data obtained in this study provides information related to the chemical nature and the acaricide activity of the C. cujete epicarp that has not been previously reported. This study shows that the ethyl acetate phase of the ethanol extract of C. cujete fruit pulp is a potential alternative control for R. microplus and its activity is in part associated to cinnamic acid, its major compound.
[Mh] Termos MeSH primário: Acaricidas/química
Acaricidas/farmacologia
Bignoniaceae/química
Frutas/química
Extratos Vegetais/farmacologia
Rhipicephalus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bovinos
Resistência a Medicamentos
Larva/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-017-5425-y


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[PMID]:28351401
[Au] Autor:Ionita R; Postu PA; Beppe GJ; Mihasan M; Petre BA; Hancianu M; Cioanca O; Hritcu L
[Ad] Endereço:Department of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I, No. 11, 700506, Iasi, Romania.
[Ti] Título:Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine.
[So] Source:Behav Brain Funct;13(1):5, 2017 Mar 28.
[Is] ISSN:1744-9081
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun. Markhamia tomentosa (Benth.) K. Schum. (Bignoniaceae) is used as an antimalarial, anti-inflammatory, analgesic, antioxidant and anti-Alzheimer agent. The current study was undertaken in order to investigate its anti-amnesic and antioxidant potential on scopolamine-induced cognitive impairment and to determine its possible mechanism of action. METHODS: Rats were pretreated with the aqueous extract (50 and 200 mg/kg, p.o.), for 10 days, and received a single injection of scopolamine (0.7 mg/kg, i.p.) before training in Y-maze and radial arm-maze tests. The biochemical parameters in the rat hippocampus were also assessed to explore oxidative status. Statistical analyses were performed using two-way ANOVA followed by Tukey's post hoc test. F values for which p < 0.05 were regarded as statistically significant. RESULTS: In the scopolamine-treated rats, the aqueous extract improved memory in behavioral tests and decreased the oxidative stress in the rat hippocampus. Also, the aqueous extract exhibited anti-acetylcholinesterase activity. CONCLUSIONS: These results suggest that the aqueous extract ameliorates scopolamine-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.
[Mh] Termos MeSH primário: Bignoniaceae/química
Cognição/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Hipocampo/efeitos dos fármacos
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Transtornos da Memória/tratamento farmacológico
Modelos Animais
Estresse Oxidativo/efeitos dos fármacos
Casca de Planta/química
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Wistar
Hidrobrometo de Escopolamina/farmacologia
Memória Espacial/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1186/s12993-017-0123-6


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[PMID]:28303339
[Au] Autor:Bittencourt Júnior NS
[Ad] Endereço:Departamento de Zoologia e Botânica, Instituto de Biociências Letras e Ciências Exatas, Universidade Estadual Paulista "Júlio de Mesquita Filho", Rua Cristóvão Colombo 2265, Jardim Nazareth, CEP 15054-000, São José do Rio Preto, São Paulo, Brazil. nesbitte@ibilce.unesp.br.
[Ti] Título:Evidence for post-zygotic self-incompatibility in Handroanthus impetiginosus (Bignoniaceae).
[So] Source:Plant Reprod;30(2):69-79, 2017 Jun.
[Is] ISSN:2194-7961
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Late-acting self-incompatibility (LSI) has been defined as a genetically controlled self-sterility mechanism that prevents seed set by selfing, despite normal pollen tube growth and ovule penetration in self-pollinated pistils. In species of the Bignoniaceae with LSI, such as Handroanthus impetiginosus, the selfed pistils are characterized by a marked delay in ovule penetration, fertilization, and endosperm initiation, followed by uniform pistil abscission. This highlights the contentious possibility of a post-zygotic self-incompatibility system. However, previous studies were unable to confirm fusion of the sperm and egg cell nuclei in selfed ovules. In the present study, the cytology of the embryo sac, double fertilization, and pistil longevity was investigated in H. impetiginosus using comparative nuclei microspectrofluorometry of DAPI-stained sections of self- vs. unpollinated pistils. Differences in both pistil longevity and ovary size between self- and unpollinated flowers at the time of pistil abscission were significant. Zygotes with double the DNA content in their nuclei relative to unfertilized egg cell nuclei were verified in selfed ovules from the first day after pollination onward, and G1 karyogamy appeared to have occurred. Our cytological analysis clearly indicates that ovules of self-pollinated pistils in H. impetiginosus are fertilized before pistil abscission but no embryogenesis initiation occurs, which strongly supports the idea of a post-zygotic self-incompatibility mechanism.
[Mh] Termos MeSH primário: Bignoniaceae/fisiologia
Autoincompatibilidade em Angiospermas
[Mh] Termos MeSH secundário: Bignoniaceae/genética
DNA de Plantas
Flores/fisiologia
Microespectrofotometria
Polinização
Autoincompatibilidade em Angiospermas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1007/s00497-017-0300-7


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[PMID]:28288826
[Au] Autor:Calil Brondani J; Reginato FZ; da Silva Brum E; de Souza Vencato M; Lima Lhamas C; Viana C; da Rocha MI; de Freitas Bauermann L; Manfron MP
[Ad] Endereço:Department of Industrial Pharmacy, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: juliana.brondani@gmail.com.
[Ti] Título:Evaluation of acute and subacute toxicity of hydroethanolic extract of Dolichandra unguis-cati L. leaves in rats.
[So] Source:J Ethnopharmacol;202:147-153, 2017 Apr 18.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Dolichandra unguis-cati L. is a native climbing plant of Brazil, popularly known as "unha de gato". It has been traditionally used mainly as an antipyretic, anti-inflammatory and anti-tumor agent, yet little toxicological information is found in the literature. AIM OF THE STUDY: To identify the chemical composition of the hydroethanolic extract obtained from the leaves of Dolichandra uniguis-cati and to evaluate the acute and subacute toxicity in male and female rats, in order to assess the safety profile of this plant. MATERIALS AND METHODS: In the acute study, a single dose (2000mg/kg) of the extract was orally administered to male and female rats. In the subacute study, the extract was orally administered to male and female rats at doses 100, 200 and 400mg/kg for 28 days. Behavioral changes, catalase and tbars evaluations, biochemical, hematological and histopathological analysis were determined. The extract' chemical composition was accessed through UHPLC/MS. RESULTS: Chlorogenic acid, caffeic acid, ferulic acid, vanillinic acid, p-coumaric acid, rosmarinic acid, trans-cinnamic acid, luteolin, apigenin, quercitrin and quercetin were identified in the extract. In the acute treatment, the extract was classified as safe (category 5), according to the OECD guide. In relation to the subacute study, females showed a reduction in AST (100, 200 and 400mg/kg), ALT (200mg/kg) and BUN (100 and 200mg/kg) levels, while male rats 400mg/kg presented an increase in AST levels. The Chol dosage significantly decreased in female rats in a dose-dependent manner, whereas for male rats this parameter showed no statistically significant reductions. No behavioral and histopathological changes were recorded. CONCLUSIONS: Our results indicate that the hydroethanolic extract of Dolichandra unguis-cati leaves did not present relevant toxic effects when administered orally to male and female rats. The extract also showed a potential hypocholesterolemic activity.
[Mh] Termos MeSH primário: Bignoniaceae/toxicidade
Extratos Vegetais/toxicidade
Folhas de Planta/toxicidade
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Aspartato Aminotransferases/metabolismo
Comportamento Animal/efeitos dos fármacos
Bignoniaceae/química
Catalase/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/enzimologia
Doença Hepática Induzida por Substâncias e Drogas/patologia
Relação Dose-Resposta a Droga
Feminino
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/patologia
Masculino
Extratos Vegetais/análise
Folhas de Planta/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); EC 1.11.1.6 (Catalase); EC 2.6.1.1 (Aspartate Aminotransferases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


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[PMID]:28056420
[Au] Autor:Sun W; Sang Y; Zhang B; Yu X; Xu Q; Xiu Z; Dong Y
[Ad] Endereço:School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning, China.
[Ti] Título:Synergistic effects of acarbose and an Oroxylum indicum seed extract in streptozotocin and high-fat-diet induced prediabetic mice.
[So] Source:Biomed Pharmacother;87:160-170, 2017 Mar.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Prediabetes is defined as blood glucose levels above normal but below diabetes thresholds, and up to 70% of individuals with prediabetes will eventually develop diabetes if left untreated. Acarbose, the first FDA approved anti-prediabetes agent, has some disadvantages, such as reducing the risk of diabetes by only 36%, side effects and limited effects on complications. The aim of this study is to develop a new agent to treat prediabetes and to investigate the anti-prediabetes effects and mechanisms of acarbose and an Oroxylum indicum seed extract (OISE) in prediabetic mice. The combined drugs can reduce the dose of acarbose by 80% and reduce the risk of diabetes by 75%, which is one fold higher than acarbose monotherapy. The combined drugs showed synergistic anti-prediabetes effects and could be effective in preventing the complications of prediabetes. The combined drugs could improve glucose tolerance, improve lipid metabolism and reduce oxidative stress and tissue damage. For the mechanisms, the combined drugs can reduce synergistically postprandial hyperglycaemia by inhibiting α-glucosidase. Furthermore, baicalein in OISE was demonstrated to be a major component in reducing oxidative stress and chrysin was the primary compound that activated PPARγ.
[Mh] Termos MeSH primário: Acarbose/administração & dosagem
Bignoniaceae
Diabetes Mellitus Experimental/tratamento farmacológico
Dieta Hiperlipídica/efeitos adversos
Extratos Vegetais/administração & dosagem
Estado Pré-Diabético/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/metabolismo
Sinergismo Farmacológico
Células HEK293
Células Hep G2
Seres Humanos
Hipoglicemiantes/administração & dosagem
Masculino
Camundongos
Casca de Planta
Extratos Vegetais/isolamento & purificação
Estado Pré-Diabético/etiologia
Estado Pré-Diabético/metabolismo
Sementes
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Extracts); 5W494URQ81 (Streptozocin); T58MSI464G (Acarbose)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170710
[Lr] Data última revisão:
170710
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE


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Vilegas, Wagner
Texto completo
[PMID]:28010885
[Au] Autor:da Rocha CQ; de-Faria FM; Marcourt L; Ebrahimi SN; Kitano BT; Ghilardi AF; Luiz Ferreira A; de Almeida AC; Dunder RJ; Souza-Brito AR; Hamburger M; Vilegas W; Queiroz EF; Wolfender JL
[Ad] Endereço:Institute of Biosciences, Coastal Campus of São Vicente, Universidade Estadual Paulista-UNESP, 11330-900, São Vicente, SP, Brazil; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Centre Medical Universitaire-CMU, Rue Michel-Servet 1, CH-1211, Geneva 4, Switzerland.
[Ti] Título:Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols.
[So] Source:Phytochemistry;135:93-105, 2017 Mar.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/isolamento & purificação
Anti-Inflamatórios não Esteroides/farmacologia
Antiulcerosos/isolamento & purificação
Antiulcerosos/farmacologia
Bignoniaceae/química
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Plantas Medicinais/química
Polifenóis/isolamento & purificação
Polifenóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/química
Antiulcerosos/química
Brasil
Citoproteção
Flavonoides/farmacologia
Glicosídeos/química
Masculino
Folhas de Planta/química
Raízes de Plantas/química
Polifenóis/química
Ratos
Ratos Wistar
Úlcera Gástrica/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Anti-Ulcer Agents); 0 (Flavonoids); 0 (Glycosides); 0 (Polyphenols)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


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[PMID]:27937112
[Au] Autor:Ibrahim M; Kaushik N; Sowemimo A; Chhipa H; Koekemoer T; van de Venter M; Odukoya OA
[Ad] Endereço:a Department of Pharmacognosy, Faculty of Pharmacy , University of Lagos, College of Medicine campus , Lagos , Nigeria.
[Ti] Título:Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa.
[So] Source:Pharm Biol;55(1):590-595, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Plants harbor endophytes with potential bioactivity. Markhamia tomentosa (Benth) K. Schum ex. Engl. (Bignoniaceae) is reported to possess antioxidant, anti-inflammatory and anticancer activities. OBJECTIVE: The antifungal and antiproliferative properties of endophytic fungi extracts and fractions from M. tomentosa were evaluated. MATERIAL AND METHODS: Endophytic fungi were isolated from the leaves of M. tomentosa and identified by ITS-rDNA sequence analysis. The antagonistic effect of the fungal strains was investigated against pathogenic fungi viz, Fusarium oxysporum, Sclerotinia sclerotiorium, Rhizoctonia solani, and Botrytis cinerea using the dual culture assay for 5-7 days. Antiproliferative effect of the fungal extracts and fractions (3.91-250 µg/mL) on HeLa cancer cell line was tested and IC was calculated. Poisoning food assay and antifeedant activity against the pathogenic fungi and Spodoptera litura larvae, for 7 days and 2 h, respectively, was also tested at concentrations of 250, 500 and 1000 µg/mL. RESULTS: Fungal endophytes Trichoderma longibrachiatum and Syncephalastrum racemosum were isolated from the leaves of M. tomentosa. Isolated endophytic fungal strains and solvent extracts showed MIC value of 1000 µg/mL against tested pathogenic fungi in the dual culture and poisoning food assays. Methanol fraction of S. racemosum isolate showed the most effective antiproliferative activity with IC of 43.56 µg/mL. Minimal feeding deterrent activity against S. litura larvae was also observed. DISCUSSION AND CONCLUSION: These findings showed that the leaves of Markhamia tomentosa harbor strains of endophytic fungi with promising health benefits, and suggest their antifungal and antiproliferative effects against pathogenic fungi and HeLa cancer cell line.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Bignoniaceae/microbiologia
Proliferação Celular/efeitos dos fármacos
Endófitos/metabolismo
Mucorales/metabolismo
Extratos Vegetais/farmacologia
Folhas de Planta/microbiologia
Trichoderma/metabolismo
Neoplasias do Colo do Útero/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antifúngicos/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Ascomicetos/efeitos dos fármacos
Ascomicetos/crescimento & desenvolvimento
Bignoniaceae/química
Botrytis/efeitos dos fármacos
Botrytis/crescimento & desenvolvimento
Relação Dose-Resposta a Droga
Endófitos/isolamento & purificação
Feminino
Fermentação
Fusarium/efeitos dos fármacos
Fusarium/crescimento & desenvolvimento
Células HeLa
Seres Humanos
Concentração Inibidora 50
Larva/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Mucorales/isolamento & purificação
Fitoterapia
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Plantas Medicinais
Rhizoctonia/efeitos dos fármacos
Rhizoctonia/crescimento & desenvolvimento
Spodoptera/efeitos dos fármacos
Spodoptera/crescimento & desenvolvimento
Fatores de Tempo
Trichoderma/isolamento & purificação
Neoplasias do Colo do Útero/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27870312
[Au] Autor:Duarte MO; Mendes-Rodrigues C; Alves MF; Oliveira PE; Sampaio DS
[Ad] Endereço:Instituto de Biologia, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brazil.
[Ti] Título:Mixed pollen load and late-acting self-incompatibility flexibility in Adenocalymma peregrinum (Miers) L.G. Lohmann (Bignonieae: Bignoniaceae).
[So] Source:Plant Biol (Stuttg);19(2):140-146, 2017 Mar.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mixed cross and self-pollen load on the stigma (mixed pollination) of species with late-acting self-incompatibility system (LSI) can lead to self-fertilized seed production. This "cryptic self-fertility" may allow selfed seedling development in species otherwise largely self-sterile. Our aims were to check if mixed pollinations would lead to fruit set in LSI Adenocalymma peregrinum, and test for evidence of early-acting inbreeding depression in putative selfed seeds from mixed pollinations. Experimental pollinations were carried out in a natural population. Fruit and seed set from self-, cross and mixed pollinations were analysed. Further germination tests were carried out for the seeds obtained from treatments. Our results confirm self-incompatibility, and fruit set from cross-pollinations was three-fold that from mixed pollinations. This low fruit set in mixed pollinations is most likely due to a greater number of self- than cross-fertilized ovules, which promotes LSI action and pistil abortion. Likewise, higher percentage of empty seeds in surviving fruits from mixed pollinations compared with cross-pollinations is probably due to ovule discounting caused by self-fertilization. Moreover, germinability of seeds with developed embryos was lower in fruits from mixed than from cross-pollinations, and the non-viable seeds from mixed pollinations showed one-third of the mass of those from cross-pollinations. The great number of empty seeds, lower germinability, lower mass of non-viable seeds, and higher variation in seed mass distribution in mixed pollinations, strongly suggests early-acing inbreeding depression in putative selfed seeds. In this sense, LSI and inbreeding depression acting together probably constrain self-fertilized seedling establishment in A. peregrinum.
[Mh] Termos MeSH primário: Bignoniaceae/fisiologia
Depressão por Endogamia
Polinização
Autoincompatibilidade em Angiospermas
[Mh] Termos MeSH secundário: Bignoniaceae/genética
Bignoniaceae/crescimento & desenvolvimento
Biomassa
Flores/genética
Flores/crescimento & desenvolvimento
Flores/fisiologia
Frutas/genética
Frutas/crescimento & desenvolvimento
Frutas/fisiologia
Germinação
Óvulo Vegetal/genética
Óvulo Vegetal/crescimento & desenvolvimento
Óvulo Vegetal/fisiologia
Pólen/genética
Pólen/crescimento & desenvolvimento
Pólen/fisiologia
Plântulas/genética
Plântulas/crescimento & desenvolvimento
Plântulas/fisiologia
Sementes/genética
Sementes/crescimento & desenvolvimento
Sementes/fisiologia
Autofertilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12526


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[PMID]:27864110
[Au] Autor:De Prá SD; Ferro PR; Milioli AM; Rigo FK; Chipindo OJ; Camponogara C; Casoti R; Manfron MP; de Oliveira SM; Ferreira J; Trevisan G
[Ad] Endereço:Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense (Unesc), 88006-000 Criciúma (SC), Brazil. Electronic address: samiradaltoe5@gmail.com.
[Ti] Título:Antinociceptive activity and mechanism of action of hydroalcoholic extract and dichloromethane fraction of Amphilophium crucigerum seeds in mice.
[So] Source:J Ethnopharmacol;195:283-297, 2017 Jan 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The medicinal plant generally known as monkey's comb (Amphilophium crucigerum) has been popularly described for the treatment of neuropathic and inflammatory pain, specially seeds preparations. AIM OF THE STUDY: The goal of the present study was to evaluate the antinociceptive effect of the crude extract (Crd) and dichloromethane fraction (Dcm) of A. crucigerum seeds, and investigate the involvement of transient receptor potential vanilloid 1 (TRPV1) receptor in this effect. MATERIALS AND METHODS: Male Swiss mice were used in this study. The effects of Crd and Dcm was tested on capsaicin-induced Ca influx or the specific binding of [ H]-resiniferatoxin. Moreover, after treatment with Crd or Dcm, animals were exposed to acute pain (hot water tail-flick and capsaicin intraplantar test) or chronic pain models (injection of complete Freund's adjuvant or partial ligation of the sciatic nerve). Acute adverse effects were also noted: locomotor activity, corporal temperature, hepatic or renal damage, gastrointestinal transit alteration, and ulcerogenic activity. RESULTS: The oral administration of Crd or Dcm resulted in an antinociceptive effect in the hot water tail-flick (48°C) and capsaicin intraplantar tests. Furthermore, these preparations exhibited antinociceptive and anti-inflammatory effects in a chronic inflammatory pain model, and antinociceptive effects in a neuropathic pain model. Moreover, Crd and Dcm reduced capsaicin-induced Ca influx and diminished the [ H]-resiniferatoxin specific binding to spinal cord membranes. Acute adverse events were not found with Crd or Dcm administration. CONCLUSION: In conclusion, our results support the analgesic effect of A. crucigerum and suggest the presence of compounds that may act as TRPV1 antagonists.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Bignoniaceae/química
Dor Crônica/prevenção & controle
Etanol/química
Cloreto de Metileno/química
Neuralgia/prevenção & controle
Nociceptividade/efeitos dos fármacos
Dor Nociceptiva/prevenção & controle
Extratos Vegetais/farmacologia
Sementes/química
Solventes/química
Medula Espinal/efeitos dos fármacos
Canais de Cátion TRPV/antagonistas & inibidores
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Analgésicos/metabolismo
Analgésicos/toxicidade
Animais
Ligação Competitiva
Sinalização do Cálcio/efeitos dos fármacos
Capsaicina/farmacologia
Dor Crônica/metabolismo
Dor Crônica/fisiopatologia
Modelos Animais de Doenças
Diterpenos/metabolismo
Relação Dose-Resposta a Droga
Masculino
Camundongos
Neuralgia/metabolismo
Neuralgia/fisiopatologia
Dor Nociceptiva/metabolismo
Dor Nociceptiva/fisiopatologia
Medição da Dor
Fitoterapia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/metabolismo
Extratos Vegetais/toxicidade
Plantas Medicinais
Ligação Proteica
Transdução de Sinais/efeitos dos fármacos
Medula Espinal/metabolismo
Medula Espinal/fisiopatologia
Sinaptossomos/efeitos dos fármacos
Sinaptossomos/metabolismo
Canais de Cátion TRPV/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Diterpenes); 0 (Plant Extracts); 0 (Solvents); 0 (TRPV Cation Channels); 0 (TRPV1 protein, mouse); 3K9958V90M (Ethanol); 588X2YUY0A (Methylene Chloride); A5O6P1UL4I (resiniferatoxin); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE



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