Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.080.500 [Categoria DeCS]
Referências encontradas : 79 [refinar]
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[PMID]:28586252
[Au] Autor:Hussain H; Green IR
[Ad] Endereço:a UoN Chair of Oman's Medicinal Plants and Marine Natural Products , University of Nizwa , Nizwa , Sultanate of Oman.
[Ti] Título:Lapachol and lapachone analogs: a journey of two decades of patent research(1997-2016).
[So] Source:Expert Opin Ther Pat;27(10):1111-1121, 2017 Oct.
[Is] ISSN:1744-7674
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Lapachol (1), ß-lapachone (2) and α-lapachone (3) are three well-studied natural products isolated from Tabebuia impetiginosa having most interesting chemodiversity and demonstrating diverse biological effects. Areas covered: The current review summarizes the recent and past discovery of chemotherapeutic agents based on the compounds 1-3. This review presents an overview of patents filed over the past two decades (1997 to 2016) mostly relating to the anticancer effects of these lapachol and lapachone analogues. Expert opinion: The large number of interesting patents published on the therapeutic potential of quinones 1-3 and their synthetic derivatives lends credence to the importance of these molecules. Moreover, these quinones demonstrated potent anticancer effects towards various cancer cell lines and chemical modification of these quinones have led to products displaying enhanced anticancer effects. It is noteworthy that the majority of patents published are on the anticancer effects of quinones 1-3 and their synthetic derivatives along with a limited number of additional biological effects. It is our opinion that in order to get lead compounds, there needs to be a greater focus on the elucidation of the precise mechanism of action of these compounds including SAR and in vivo studies.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Naftoquinonas/farmacologia
Tabebuia/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Desenho de Drogas
Seres Humanos
Naftoquinonas/química
Naftoquinonas/isolamento & purificação
Neoplasias/tratamento farmacológico
Patentes como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Naphthoquinones); 4707-32-8 (beta-lapachone); B221938VB6 (lapachol); VPE3AOX9QV (alpha-lapachone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1080/13543776.2017.1339792


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[PMID]:27352388
[Au] Autor:Zhang L; Hasegawa I; Ohta T
[Ad] Endereço:College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City, Japan.
[Ti] Título:Iridoid Esters from Tabebuia avellanedae and Their In Vitro Anti-inflammatory Activities.
[So] Source:Planta Med;83(1-02):164-171, 2017 Jan.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation of the inner bark of Lorentz ex Griseb was carried out by various chromatographic techniques, resulting in the isolation and characterization of eight new iridoid esters, namely Avelladoids A-H ( - ). Their chemical structures were elucidated on the basis of extensive spectroscopic analyses, especially 2D NMR experiments and HRMS data. The anti-inflammatory effects of - were determined on an LPS-stimulated RAW 264.7 cell line. Among them, compounds , and exhibited anti-inflammatory activities by inhibition of NO and PGE production in a dose-dependent manner, without altering cell viability.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Iridoides/farmacologia
Estrutura Molecular
Extratos Vegetais/farmacologia
Tabebuia/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Vias Biossintéticas
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ésteres/química
Ésteres/isolamento & purificação
Ésteres/farmacologia
Seres Humanos
Iridoides/química
Iridoides/isolamento & purificação
Camundongos
Óxido Nítrico/metabolismo
Casca de Planta/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Esters); 0 (Iridoids); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-110322


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[PMID]:27582361
[Au] Autor:Dalling JW; Cernusak LA; Winter K; Aranda J; Garcia M; Virgo A; Cheesman AW; Baresch A; Jaramillo C; Turner BL
[Ad] Endereço:Department of Plant Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA Smithsonian Tropical Research Institute, Apartado 0843-03092, Balboa, Ancon, Republic of Panama dallingj@life.illinois.edu.
[Ti] Título:Two tropical conifers show strong growth and water-use efficiency responses to altered CO2 concentration.
[So] Source:Ann Bot;118(6):1113-1125, 2016 Nov.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Conifers dominated wet lowland tropical forests 100 million years ago (MYA). With a few exceptions in the Podocarpaceae and Araucariaceae, conifers are now absent from this biome. This shift to angiosperm dominance also coincided with a large decline in atmospheric CO concentration (c ). We compared growth and physiological performance of two lowland tropical angiosperms and conifers at c levels representing pre-industrial (280 ppm), ambient (400 ppm) and Eocene (800 ppm) conditions to explore how differences in c affect the growth and water-use efficiency (WUE) of seedlings from these groups. METHODS: Two conifers (Araucaria heterophylla and Podocarpus guatemalensis) and two angiosperm trees (Tabebuia rosea and Chrysophyllum cainito) were grown in climate-controlled glasshouses in Panama. Growth, photosynthetic rates, nutrient uptake, and nutrient use and water-use efficiencies were measured. KEY RESULTS: Podocarpus seedlings showed a stronger (66 %) increase in relative growth rate with increasing c relative to Araucaria (19 %) and the angiosperms (no growth enhancement). The response of Podocarpus is consistent with expectations for species with conservative growth traits and low mesophyll diffusion conductance. While previous work has shown limited stomatal response of conifers to c , we found that the two conifers had significantly greater increases in leaf and whole-plant WUE than the angiosperms, reflecting increased photosynthetic rate and reduced stomatal conductance. Foliar nitrogen isotope ratios (δ N) and soil nitrate concentrations indicated a preference in Podocarpus for ammonium over nitrate, which may impact nitrogen uptake relative to nitrate assimilators under high c SIGNIFICANCE: Podocarps colonized tropical forests after angiosperms achieved dominance and are now restricted to infertile soils. Although limited to a single species, our data suggest that higher c may have been favourable for podocarp colonization of tropical South America 60 MYA, while plasticity in photosynthetic capacity and WUE may help account for their continued persistence under large changes in c since the Eocene.
[Mh] Termos MeSH primário: Coniferophyta/fisiologia
[Mh] Termos MeSH secundário: Dióxido de Carbono/metabolismo
Coniferophyta/genética
Coniferophyta/crescimento & desenvolvimento
Sapotaceae/genética
Sapotaceae/crescimento & desenvolvimento
Sapotaceae/fisiologia
Plântulas/crescimento & desenvolvimento
Tabebuia/genética
Tabebuia/crescimento & desenvolvimento
Tabebuia/fisiologia
Clima Tropical
Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE


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[PMID]:27539320
[Au] Autor:Iwamoto K; Fukuda Y; Tokikura C; Noda M; Yamamoto A; Yamamoto M; Yamashita M; Zaima N; Iida A; Moriyama T
[Ad] Endereço:Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, 204-3327 Nakamachi, Nara City 631-8505, Japan.
[Ti] Título:The anti-obesity effect of Taheebo (Tabebuia avellanedae Lorentz ex Griseb) extract in ovariectomized mice and the identification of a potential anti-obesity compound.
[So] Source:Biochem Biophys Res Commun;478(3):1136-40, 2016 09 23.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Estrogen deficiency-induced obesity has a high risk of visceral fat accumulation and body weight gain. It is also associated with many adverse health conditions. Taheebo extract from Tabebuia avellanedae has been recognized as playing several biological and pharmacological roles. Therefore, we investigated whether the intake of n-BuOH extract of Taheebo shows anti-obesity effect in ovariectomized (OVX) mice. After 16 weeks of feeding, the mice administrated with 0.5% n-BuOH extract of Taheebo showed significantly decreased body weight compared with that of the control mice, and the fat mass also showed a significant decrease. In 3T3-L1 cells, supplementation with n-BuOH extract of Taheebo significantly reduced the triglyceride (TG) levels. Furthermore, bioassay-guided purification of the n-BuOH extract based on the TG levels in 3T3-L1 cells led to the isolation of compound 2 (1-dehydroxy-3,4-dihydroaucubigenin). These results suggested that the anti-obesity effect of Taheebo extract is due to its capability in preventing the accumulation of adipocyte in mice. Taheebo extract might be a promising functional food resources capable of protecting against OVX-induced obesity.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/uso terapêutico
Obesidade/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Tabebuia/química
[Mh] Termos MeSH secundário: 1-Butanol/química
Células 3T3-L1
Animais
Fármacos Antiobesidade/farmacologia
Peso Corporal/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Fezes/química
Feminino
Fígado/efeitos dos fármacos
Fígado/metabolismo
Camundongos
Obesidade/sangue
Tamanho do Órgão/efeitos dos fármacos
Ovariectomia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Plant Extracts); 0 (Taheebo); 0 (Triglycerides); 8PJ61P6TS3 (1-Butanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171127
[Lr] Data última revisão:
171127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160820
[St] Status:MEDLINE


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[PMID]:27458982
[Au] Autor:de Melo WA; Lima-Ribeiro MS; Terribile LC; Collevatti RG
[Ad] Endereço:Laboratório de Genética & Biodiversidade, ICB, Universidade Federal de Goiás (UFG), Cx.P. 131, Goiânia, GO, Brasil.
[Ti] Título:Coalescent Simulation and Paleodistribution Modeling for Tabebuia rosealba Do Not Support South American Dry Forest Refugia Hypothesis.
[So] Source:PLoS One;11(7):e0159314, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Studies based on contemporary plant occurrences and pollen fossil records have proposed that the current disjunct distribution of seasonally dry tropical forests (SDTFs) across South America is the result of fragmentation of a formerly widespread and continuously distributed dry forest during the arid climatic conditions associated with the Last Glacial Maximum (LGM), which is known as the modern-day dry forest refugia hypothesis. We studied the demographic history of Tabebuia rosealba (Bignoniaceae) to understand the disjunct geographic distribution of South American SDTFs based on statistical phylogeography and ecological niche modeling (ENM). We specifically tested the dry forest refugia hypothesis; i.e., if the multiple and isolated patches of SDTFs are current climatic relicts of a widespread and continuously distributed dry forest during the LGM. We sampled 235 individuals across 18 populations in Central Brazil and analyzed the polymorphisms at chloroplast (trnS-trnG, psbA-trnH and ycf6-trnC intergenic spacers) and nuclear (ITS nrDNA) genomes. We performed coalescence simulations of alternative hypotheses under demographic expectations from two a priori biogeographic hypotheses (1. the Pleistocene Arc hypothesis and, 2. a range shift to Amazon Basin) and other two demographic expectances predicted by ENMs (3. expansion throughout the Neotropical South America, including Amazon Basin, and 4. retraction during the LGM). Phylogenetic analyses based on median-joining network showed haplotype sharing among populations with evidence of incomplete lineage sorting. Coalescent analyses showed smaller effective population sizes for T. roseoalba during the LGM compared to the present-day. Simulations and ENM also showed that its current spatial pattern of genetic diversity is most likely due to a scenario of range retraction during the LGM instead of the fragmentation from a once extensive and largely contiguous SDTF across South America, not supporting the South American dry forest refugia hypothesis.
[Mh] Termos MeSH primário: Florestas
Fósseis
Refúgio Biológico
Tabebuia
[Mh] Termos MeSH secundário: Brasil
Variação Genética
Genética Populacional
Geografia
Modelos Estatísticos
Modelos Teóricos
Filogenia
Filogeografia
Estações do Ano
Análise de Sequência de DNA
Análise Espacial
Tabebuia/classificação
Tabebuia/genética
Clima Tropical
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0159314


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[PMID]:27454549
[Au] Autor:Suo MR; Yan SY
[Ad] Endereço:Jiyang College of Zhejiang Agriculture and Forestry University, Zhuji, 311800, P. R. China.
[Ti] Título:Iridoid Glycosides from Tabebuia avellanedae.
[So] Source:Chem Biodivers;13(12):1611-1616, 2016 Dec.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Five novel iridoid glycosides, avellanedaesides A-E (1 - 5) were isolated from the H O extract of Tabebuia avellanedae. Their structures were determined on the basis of NMR and MS analysis. Isolated compounds suppressed inflammatory cytokine, tumor-necrosis factor-α and interleukin-1ß production in cultured human myeloma THP-1 cells co-stimulated with lipopolysaccharide (LPS). In addition, the study revealed iridoid glycosides inhibited the activity of cytochrome CYP3A4 enzyme.
[Mh] Termos MeSH primário: Inibidores do Citocromo P-450 CYP3A/farmacologia
Citocromo P-450 CYP3A/metabolismo
Glicosídeos Iridoides/farmacologia
Tabebuia/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Inibidores do Citocromo P-450 CYP3A/química
Inibidores do Citocromo P-450 CYP3A/isolamento & purificação
Citocinas/antagonistas & inibidores
Relação Dose-Resposta a Droga
Seres Humanos
Glicosídeos Iridoides/química
Glicosídeos Iridoides/isolamento & purificação
Lipopolissacarídeos/farmacologia
Conformação Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytochrome P-450 CYP3A Inhibitors); 0 (Cytokines); 0 (Iridoid Glycosides); 0 (Lipopolysaccharides); EC 1.14.14.1 (Cytochrome P-450 CYP3A)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170120
[Lr] Data última revisão:
170120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600018


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[PMID]:27338330
[Au] Autor:Park JG; Son YJ; Kim MY; Cho JY
[Ad] Endereço:Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Korea. wannabejk@naver.com.
[Ti] Título:Syk and IRAK1 Contribute to Immunopharmacological Activities of Anthraquinone-2-carboxlic Acid.
[So] Source:Molecules;21(6), 2016 Jun 22.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Anthraquinone-2-carboxlic acid (9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, AQCA) was identified as one of the major anthraquinones in Brazilian taheebo. Since there was no report explaining its immunopharmacological actions, in this study, we aimed to investigate the molecular mechanism of AQCA-mediated anti-inflammatory activity using reporter gene assays, kinase assays, immunoblot analyses, and overexpression strategies with lipopolysaccharide (LPS)-treated macrophages. AQCA was found to suppress the release of nitric oxide (NO) and prostaglandin (PG) E2 from LPS-treated peritoneal macrophages without displaying any toxic side effects. Molecular analysis revealed that AQCA was able to inhibit the activation of the nuclear factor (NF)-κB and activator protein (AP)-1 pathways by direct suppression of upstream signaling enzymes including interleukin-1 receptor-associated kinase 1 (IRAK1) and spleen tyrosine kinase (Syk). Therefore, our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK and Syk, linked to the activation of NF-κB and AP-1.
[Mh] Termos MeSH primário: Antraquinonas/administração & dosagem
Inflamação/tratamento farmacológico
Quinases Associadas a Receptores de Interleucina-1/biossíntese
Quinase Syk/biossíntese
Fator de Transcrição AP-1/biossíntese
[Mh] Termos MeSH secundário: Antraquinonas/química
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/química
Brasil
Seres Humanos
Inflamação/patologia
Quinases Associadas a Receptores de Interleucina-1/antagonistas & inibidores
Lipopolissacarídeos/toxicidade
Macrófagos Peritoneais/efeitos dos fármacos
Macrófagos Peritoneais/patologia
NF-kappa B/antagonistas & inibidores
NF-kappa B/biossíntese
Óxido Nítrico/metabolismo
Prostaglandinas/metabolismo
Quinase Syk/antagonistas & inibidores
Tabebuia/química
Fator de Transcrição AP-1/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Prostaglandins); 0 (Transcription Factor AP-1); 0 (anthraquinone-2-carboxylic acid); 31C4KY9ESH (Nitric Oxide); EC 2.7.10.2 (Syk Kinase); EC 2.7.11.1 (IRAK1 protein, human); EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE


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[PMID]:27159671
[Au] Autor:Ferraz-Filha ZS; Michel Araújo MC; Ferrari FC; Dutra IP; Saúde-Guimarães DA
[Ad] Endereço:Departamento de Química, Instituto Federal de Minas Gerais-Campus Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
[Ti] Título:Tabebuia roseoalba: In Vivo Hypouricemic and Anti-inflammatory Effects of Its Ethanolic Extract and Constituents.
[So] Source:Planta Med;82(16):1395-1402, 2016 Nov.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:species have several uses in folk medicine, including their use to treat inflammation and rheumatism. The aim of this study was to investigate whether the ethanolic extract of leaves from and isolated compounds could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. The compounds -amyrin, -amyrin, sitosterol, and stigmasterol were isolated from the ethanolic extract. Rutin and caffeic acid were identified in the ethanolic extract by HPLC analysis. The anti-hyperuricemic effect, liver xanthine oxidoreductase inhibition, and anti-inflammatory activity of the ethanolic extract and isolated compounds were evaluated on hyperuricemic mice and on paw edema induced by monosodium urate crystals in mice. The ethanolic extract of leaves from -amyrin, and stigmasterol were able to reduce serum uric acid levels in hyperuricemic mice through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by monosodium urate crystals. The antioxidant activity of the ethanolic extract and its ability to inhibit xanthine oxidase were also evaluated . The ethanolic extract of leaves from showed significant antioxidant activity in the three evaluated assays. Results were analyzed using GraphPad Prism 5.01. One-way ANOVA followed by Student's Newman-Keul's test was used to determine the significant differences between groups. The results show that the ethanolic extract of leaves from -amyrin, and stigmasterol can be promising agents for the treatment for gouty arthritis, hyperuricemia, and inflammation. Stigmasterol, -amyrin, and rutin contribute to the observed effects of the ethanolic extract of leaves from .
[Mh] Termos MeSH primário: Artrite Gotosa/tratamento farmacológico
Hiperuricemia/tratamento farmacológico
Inflamação/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Tabebuia/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/análise
Antioxidantes/análise
Avaliação Pré-Clínica de Medicamentos
Supressores da Gota/análise
Masculino
Camundongos
Fitoterapia
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Gout Suppressants); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160510
[St] Status:MEDLINE


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[PMID]:26779946
[Au] Autor:Zhang L; Hasegawa I; Ohta T
[Ad] Endereço:Laboratory of Environmental and Health Science, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan; Henan University of Traditional Chinese Medicine, No. 1 Jinshui Road, Zhengzhou, Henan 450008, China. Electronic address: sonny.fairy.love@163.com.
[Ti] Título:Anti-inflammatory cyclopentene derivatives from the inner bark of Tabebuia avellanedae.
[So] Source:Fitoterapia;109:217-23, 2016 Mar.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Six new cyclopentenyl esters, avellaneine A-F (1-4, 7, 8), two new cyclopentyl esters, avellaneine G, H (9, 10), along with two known cyclopentenyl esters were obtained from water extract of the inner bark of Tabebuia avellanedae Lorentz ex Griseb. The chemical structures of the new compounds were elucidated by spectroscopic techniques. The anti-inflammatory effects of these compounds were determined on LPS-stimulated RAW 264.7 cell line. Some of the tested compounds (2, 3, 4, 6, 7) reduced the NO production in a dose-dependent manner, while 6 and 7 decreased PGE2 production in a dose-dependent manner, without altering cell viability. Data presented in this research indicated that Tabebuia avellanedae's ethnopharmacological action of treating inflammatory diseases was based on the constituents which exert a significant anti-inflammatory effect on inflammatory responses.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Benzoatos/química
Ciclopentanos/química
Casca de Planta/química
Tabebuia/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Benzoatos/isolamento & purificação
Ciclopentanos/isolamento & purificação
Dinoprostona/antagonistas & inibidores
Ésteres/química
Ésteres/isolamento & purificação
Camundongos
Óxido Nítrico/metabolismo
Extratos Vegetais/química
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzoates); 0 (Cyclopentanes); 0 (Esters); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160301
[Lr] Data última revisão:
160301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE


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[PMID]:26703544
[Au] Autor:Pires TC; Dias MI; Calhelha RC; Carvalho AM; Queiroz MJ; Barros L; Ferreira IC
[Ad] Endereço:Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 1172, 5301-855 Bragança, Portugal. tania.pires@ipb.pt.
[Ti] Título:Bioactive Properties of Tabebuia impetiginosa-Based Phytopreparations and Phytoformulations: A Comparison between Extracts and Dietary Supplements.
[So] Source:Molecules;20(12):22863-71, 2015 Dec 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Tabebuia impetiginosa (Mart. ex DC.) Standl. has been used in traditional medicine for many centuries, being nowadays marketed as dried plant material (inner bark) for infusions, pills, and syrups. The main objective of the present work was to validate its popular use through the bioactivity evaluation of the inner bark (methanolic extract and infusion) and of two different formulations (pills and syrup) also based on the same plant-material. The antioxidant activity was evaluated by in vitro assays testing free radical scavenging activity, reducing power and inhibition of lipid peroxidation in brain homogenates. The cytotoxicity was determined in four human tumor cell lines (MCF-7, NCI-H460, HeLa and HepG2, and also in non-tumor cells (porcine liver primary cells, PLP2)). Furthermore, the sample was chemically characterized regarding free sugars, organic acids, fatty acids, and tocopherols. Syrup and methanolic extract showed the highest antioxidant activity, related to their highest amount of phenolics and flavonoids. Methanolic extract was the only sample showing cytotoxic effects on the tested human tumor cell lines, but none of the samples showed toxicity in PLP2. Glucose and oxalic acid were, respectively, the most abundant sugar and organic acid in the sample. Unsaturated predominated over the saturated fatty acids, due to oleic, linoleic, and linolenic acids expression. α- and γ-Tocopherols were also identified and quantified. Overall, T. impetiginosa might be used in different phytoformulations, taking advantage of its interesting bioactive properties and chemical composition.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacocinética
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
Tabebuia/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antioxidantes/química
Linhagem Celular
Linhagem Celular Tumoral
Suplementos Nutricionais
Flavonoides/química
Flavonoides/farmacologia
Glucose/metabolismo
Células HeLa
Células Hep G2
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Células MCF-7
Medicina Tradicional/métodos
Ácido Oxálico/metabolismo
Fenóis/química
Fenóis/farmacologia
Extratos Vegetais/química
Suínos
Tocoferóis/química
Tocoferóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 9E7R5L6H31 (Oxalic Acid); IY9XDZ35W2 (Glucose); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151226
[St] Status:MEDLINE
[do] DOI:10.3390/molecules201219885



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