Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.520 [Categoria DeCS]
Referências encontradas : 1706 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 171 ir para página                         

  1 / 1706 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29391002
[Au] Autor:Kahaliw W; Hellman B; Engidawork E
[Ad] Endereço:Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, P. O. Box: 196, Gondar, Ethiopia. wubayehu.kahaliw@uog.edu.et.
[Ti] Título:Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells.
[So] Source:BMC Complement Altern Med;18(1):45, 2018 Feb 01.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Most of herbal medicines are used without any standard safety and toxicological trials although common assumption is that these products are nontoxic. However, this assumption is incorrect and dangerous, so toxicological studies should be done for herbal drugs. Although Pterolobium stellatum, Otostegia integrifolia and Vernonia amygdalina root extracts are frequently used in Ethiopian traditional medicine, there are no evidences of their active toxic compounds. Therefore, we made an effort to assess probable genotoxic effect of these plant extracts on DNA of human hematoma (HepG ) cells using alkaline comet assay. METHODS: Genotoxic effects of extracts were evaluated using single cell gel electrophoresis (SCGE) method on HepG cell. Regarding comet data, the average mean tail intensities (TI) from each individual experiment and treatment (usually at least 3 cultures/treatment) were pooled and the average mean TI was used as an indicator of DNA damage and the standard error of mean (SEM) as the measure of variance. RESULTS: DNA damage in the form of comet tail has been observed for 1 and 0.5 mg/ml P. stellatum chloroform and 80% methanol extracts on HepG cells, respectively. The chloroform extract of P. stellatum showed increased tail DNA percentage in a concentration dependent manner. Comet tail length in the chloroform P. stellatum extract treated cells (1 mg/ml) was significantly higher by 89% (p < 0.05) compared to vehicle treated controls. The rest of test extracts seemed to be without genotoxic effect up to a concentration of 0.5 mg/ml. CONCLUSIONS: Our findings show that two extracts from one plant evaluated have a genotoxic potential in vitro which calls for a more thorough safety evaluation. Such evaluation should include other end-points of genotoxicity apart from DNA damage, and possibly also pure compounds.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
Mutagênicos/toxicidade
Extratos Vegetais/toxicidade
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Ensaio Cometa
Fabaceae/química
Células Hep G2
Seres Humanos
Lamiaceae/química
Testes de Mutagenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens); 0 (Plant Extracts)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2056-x


  2 / 1706 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28946270
[Au] Autor:Pereira E; Antonio A; Barreira JCM; Santos-Buelga C; Barros L; Ferreira ICFR
[Ad] Endereço:Centrode Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal; GIP-USAL, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
[Ti] Título:How gamma and electron-beam irradiations modulate phenolic profile expression in Melissa officinalis L. and Melittis melissophyllum L.
[So] Source:Food Chem;240:253-258, 2018 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Owing to the overall increase in herbal infusions' consumption, there's a progressively higher need of suitable plant material, as well as adequate conservation techniques to maintain its quality. Among, the available technologies, irradiation is gaining interest as a feasible preservation method. In line with this approach, this wok was designed to evaluate the effects of electron-beam and gamma irradiation over the phenolic profiles of two plant species Melissa officinalis L. (LB) and Melittis melissophyllum L. (BB). Individual phenolics were characterized by high-performance liquid chromatography coupled to a diode array detector and a mass spectrometer (HPLC-DAD-ESI/MS). Irradiated samples showed a general increase in individual phenolic contents, especially in lithospermic acid A in LB and 5-O-caffeoylquinic acid in BB. Thus, this study revealed the potential usefulness of both conservation technologies when employed to this type of plants.
[Mh] Termos MeSH primário: Lamiaceae
Melissa
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Elétrons
Fenóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE


  3 / 1706 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28931016
[Au] Autor:Zhang ML; Zeng XQ; Sanderson SC; Byalt VV; Sukhorukov AP
[Ad] Endereço:Key Laboratory of Biogeography and Bioresource in Arid Land, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China.
[Ti] Título:Insight into Central Asian flora from the Cenozoic Tianshan montane origin and radiation of Lagochilus (Lamiaceae).
[So] Source:PLoS One;12(9):e0178389, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Tianshan Mountains play a significant role in the Central Asian flora and vegetation. Lagochilus has a distribution concentration in Tianshan Mountains and Central Asia. To investigate generic spatiotemporal evolution, we sampled most Lagochilus species and sequenced six cpDNA locations (rps16, psbA-trnH, matK, trnL-trnF, psbB-psbH, psbK-psbI). We employed BEAST Bayesian inference for dating, and S-DIVA, DEC, and BBM for ancestral area/biome reconstruction. Our results clearly show that the Tianshan Mountains, especially the western Ili-Kirghizia Tianshan, as well as Sunggar and Kaschgar, was the ancestral area. Ancestral biome was mainly in the montane steppe zone of valley and slope at altitudes of 1700-2700 m, and the montane desert zone of foothill and front-hill at 1000-1700 m. Here two sections Inermes and Lagochilus of the genus displayed "uphill" and "downhill" speciation process during middle and later Miocene. The origin and diversification of the genus were explained as coupled with the rapid uplift of the Tianshan Mountains starting in late Oligocene and early Miocene ca. 23.66~19.33 Ma, as well as with uplift of the Qinghai-Tibetan Plateau (QTP) and Central Asian aridification.
[Mh] Termos MeSH primário: Ecossistema
Lamiaceae/genética
[Mh] Termos MeSH secundário: Teorema de Bayes
DNA de Plantas/química
DNA de Plantas/classificação
DNA de Plantas/isolamento & purificação
DNA de Plantas/metabolismo
Evolução Molecular
Variação Genética
Quirguistão
Filogenia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178389


  4 / 1706 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28882484
[Au] Autor:Suto Y; Sato M; Fujimori K; Kitabatake S; Okayama M; Ichikawa D; Matsushita M; Yamagiwa N; Iwasaki G; Kiuchi F; Hattori Y
[Ad] Endereço:Faculty of Pharmacy, Takasaki University of Health and Welfare, Gunma 370-0033, Japan. Electronic address: ysuto@takasaki-u.ac.jp.
[Ti] Título:Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma.
[So] Source:Bioorg Med Chem Lett;27(19):4558-4563, 2017 10 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alternatives of treatments for multiple myeloma (MM) have become increasingly available with the advent of new drugs such as proteasome inhibitors, thalidomide derivatives, histone deacetylase inhibitors, and antibody drugs. However, high-risk MM cases that are refractory to novel drugs remain, and further optimization of chemotherapeutics is urgently needed. We had achieved asymmetric total synthesis of komaroviquinone, which is a natural product from the plant Dracocephalum komarovi. Similar to several leading antitumor agents that have been developed from natural compounds, we describe the antitumor activity and cytotoxicity of komaroviquinone and related compounds in bone marrow cells. Our data suggested that komaroviquinone-related agents have potential as starting compounds for anticancer drug development.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Produtos Biológicos/farmacologia
Diterpenos/farmacologia
Lamiaceae/química
Mieloma Múltiplo/tratamento farmacológico
Quinonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/síntese química
Antineoplásicos Fitogênicos/química
Produtos Biológicos/síntese química
Produtos Biológicos/química
Células da Medula Óssea/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Diterpenos/síntese química
Diterpenos/química
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Camundongos
Estrutura Molecular
Mieloma Múltiplo/patologia
Quinonas/síntese química
Quinonas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Biological Products); 0 (Diterpenes); 0 (Quinones); 0 (komaroviquinone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


  5 / 1706 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28777980
[Au] Autor:Choudhary AK; Sunojkumar P; Mishra G
[Ad] Endereço:Department of Botany, University of Delhi, Delhi, 110007, India.
[Ti] Título:Fatty acid profiling and multivariate analysis in the genus Leucas reveals its nutritional, pharmaceutical and chemotaxonomic significance.
[So] Source:Phytochemistry;143:72-80, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Genus Leucas with about 41 species found in India, is an Asian genus with separation from its close relatives in Africa based on phylogenetic evidence. Present study represents the only comprehensive phytochemical investigation on this genus. We have analyzed the seed fatty acid compositions of 26 species and five varieties of Leucas for nutritional, pharmaceutical and chemotaxonomic perspectives. The fatty acids and their composition in seeds of Leucas species, collected from different geographical regions in India, were analyzed by gas chromatography and mass spectrometry. Significant variations have been observed in fatty acid profiles among species and their varieties. We observed major fatty acids as palmitic, stearic, oleic, linoleic and laballenic acid; whereas myristic, palmitoleic, cis-vaccenic, linolenic, eicosanoic, eicosenoic, phlomic and docosanoic acid were detected in minor quantities. Laballenic and phlomic acids are unusual allenic fatty acids found in few Lamiaceae members from order Lamiales. Laballenic acid, a proven molecule of pharmaceutical importance, was observed in all the Leucas species studied. Three species of Leucas; L. helianthimifolia, L. ciliata var. vestita and L. hirta were found to contain ≥40% laballenic acid and can act as potential source for isolation of pharmaceutical compounds. This study also reports the presence of another allenic fatty acid, phlomic acid, in several Leucas species. Principal component analysis and hierarchical cluster analysis showed a distinct separation among the species based on abundance of similar fatty acids. The fatty acid profile appears to be overlapping at higher level and does not support separation of Asian Leucas from its African relatives and the inclusion of Asian taxa in morphologic sections. However, hierarchical clustering of L. helianthimifolia, L. ciliata var. vestita and L. hirta supported treatment under the morphologic section Astrodon. Multivariate analysis on the chemometric data also supported this cluster as the most prominent source of medicinally useful laballenic acid. Based on the FAs profile, a reconsideration of species boundaries in L. ciliata and L. marrubioides species complex is proposed.
[Mh] Termos MeSH primário: Ácidos Graxos/análise
Lamiaceae/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Índia
Lamiaceae/genética
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); H390488X0A (behenic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


  6 / 1706 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28750031
[Au] Autor:Deng M; Dong Y; Zhao Z; Li Y; Fan G
[Ad] Endereço:College of Forestry, Henan Agricultural University, Zhengzhou, Henan, P.R. China.
[Ti] Título:Dissecting the proteome dynamics of the salt stress induced changes in the leaf of diploid and autotetraploid Paulownia fortunei.
[So] Source:PLoS One;12(7):e0181937, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exposure to high salinity can trigger acclimation in many plants. Such an adaptative response is greatly advantageous for plants and involves extensive reprogramming at the molecular level. Acclimation allows plants to survive in environments that are prone to increasing salinity. In this study, diploid and autotetraploid Paulownia fortunei seedlings were used to detect alterations in leaf proteins in plants under salt stress. Up to 152 differentially abundant proteins were identified by Multiplex run iTRAQ-based quantitative proteomic and LC-MS/MS methods. Bioinformatics analysis suggested that P. fortunei leaves reacted to salt stress through a combination of common responses, such as induced metabolism, signal transduction, and regulation of transcription. This study offers a better understanding of the mechanisms of salt tolerance in P. fortunei and provides a list of potential target genes that could be engineered for salt acclimation in plants, especially trees.
[Mh] Termos MeSH primário: Diploide
Lamiaceae/metabolismo
Lamiaceae/fisiologia
Folhas de Planta/fisiologia
Proteoma/metabolismo
Cloreto de Sódio/farmacologia
Estresse Fisiológico/efeitos dos fármacos
Tetraploidia
[Mh] Termos MeSH secundário: Análise por Conglomerados
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Ontologia Genética
Marcação por Isótopo
Lamiaceae/efeitos dos fármacos
Lamiaceae/genética
Folhas de Planta/genética
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Proteômica
Reação em Cadeia da Polimerase em Tempo Real
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Proteome); 451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181937


  7 / 1706 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28673306
[Au] Autor:Rolim TL; Meireles DRP; Batista TM; de Sousa TKG; Mangueira VM; de Abrantes RA; Pita JCLR; Xavier AL; Costa VCO; Batista LM; da Silva MS; Sobral MV
[Ad] Endereço:Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, Paraíba, 58051-970, Brazil.
[Ti] Título:Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component.
[So] Source:BMC Complement Altern Med;17(1):347, 2017 Jul 03.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The essential oil from Mesosphaerum sidifolium (L'Hérit.) Harley & J.F.B.Pastore (syn. Hyptis umbrosa), Lamiaceae (EOM), and its major component, have been tested for toxicity and antitumor activity. METHODS: EOM was obtained from aerial parts of M. sidifolium subjected to hydro distillation, and gas chromatography-mass spectrometry was used to characterize the EOM chemical composition. The toxicity was evaluated using haemolysis assay, and acute toxicity and micronucleus tests. Ehrlich ascites carcinoma model was used to evaluate the in vivo antitumor activity and toxicity of EOM (50, 100 and 150 mg/kg), and fenchone (30 and 60 mg/kg) after 9 d of treatment. RESULTS: The EOM major components were fenchone (24.8%), cubebol (6.9%), limonene (5.4%), spathulenol (4.5%), ß-caryophyllene (4.6%) and α-cadinol (4.7%). The HC50 (concentration producing 50% haemolysis) was 494.9 µg/mL for EOM and higher than 3000 µg/mL for fenchone. The LD50 for EOM was approximately 500 mg/kg in mice. The essential oil induced increase of micronucleated erythrocytes only at 300 mg/kg, suggesting moderate genotoxicity. EOM (100 or 150 mg/kg) and fenchone (60 mg/kg) reduced all analyzed parameters (tumor volume and mass, and total viable cancer cells). Survival also increased for the treated animals with EOM and fenchone. For EOM 150 mg/kg and 5-FU treatment, most cells were arrested in the G0/G1 phase, whereas for fenchone, cells arrested in the S phase, which represents a blockage in cell cycle progression. Regarding the toxicological evaluation, EOM induced weight loss, but did not induce hematological, biochemical or histological (liver and kidneys) toxicity. Fenchone induced decrease of AST and ALT, suggesting liver damage. CONCLUSIONS: The data showed EOM caused in vivo cell growth inhibition on Ehrlich ascites carcinoma model by inducing cell cycle arrest, without major changes in the toxicity parameters evaluated. In addition, this activity was associated with the presence of fenchone, its major component.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/administração & dosagem
Carcinoma de Ehrlich/tratamento farmacológico
Lamiaceae/química
Norbornanos/administração & dosagem
Óleos Voláteis/administração & dosagem
Óleos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/toxicidade
Carcinoma de Ehrlich/fisiopatologia
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Feminino
Seres Humanos
Camundongos
Norbornanos/química
Norbornanos/toxicidade
Óleos Voláteis/química
Óleos Voláteis/toxicidade
Óleos Vegetais/química
Óleos Vegetais/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Norbornanes); 0 (Oils, Volatile); 0 (Plant Oils); 1195-79-5 (fenchone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1779-z


  8 / 1706 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28603120
[Au] Autor:Riaz T; Abbasi MA; Rehman A; Siddiqui SZ; Shahid M; Fatima H; Ashraf M; Ejaz SA; Rasool ZG; Abbasi GH
[Ad] Endereço:Department of Chemistry, Government College for Women University, Sialkot, Pakistan.
[Ti] Título:Enzyme inhibitory, Antifungal, Antibacterial and hemolytic potential of various fractions of Colebrookia oppositifolia.
[So] Source:Pak J Pharm Sci;30(1):105-112, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The purpose of the present investigation was to assess the enzyme inhibition, antifungal, antibacterial and hemolytic activities of various fractions of Colebrookia oppositifolia Smith. The MeOH extract of plant was dissolved in dist. water and partitioned with n-hexane, CHCl3, EtOAc and n-BuOH sequentially. Enzyme inhibition studies were done against four enzymes i.e. α-glucosidase, butyrylcholinesterase, acetyl cholinesterase and lipoxygenase. Ethyl acetate fraction possessed very good activity against α-glucosidase (IC 57.38±1.23µg/mL). CHCl3 fraction displayed good activity against α-glucosidase and lipoxygenase while moderate activity against butyryl cholinesterase. EtOAc fraction displayed good activity against lipoxygenase. Antifungal activity was studied against four fungi i.e. Aspergillus niger, Aspergillus flavus, Ganoderma lucidum and Alternaria alternata by the disc diffusion method using fluconazole, a standard antifungal drug, as positive control. Aqueous fraction displayed good activity against G. lucidum and A. flavus. Antibacterial activity was checked against Staphylococcus aureus, Bacillus subtilis, Pasturella multocida and Escherichia coli by the disc diffusion method using streptomycin sulphate, a standard antibiotic, as positive control. Chloroform, ethyl acetate and aqueous fraction showed good activity against E. coli. Chloroform fraction showed good activity against B. subtilis. Ethyl acetate fraction showed good activity against the P. multocida. All the studied fractions showed very less toxicity i.e. < 7%.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Inibidores Enzimáticos/farmacologia
Hemólise/efeitos dos fármacos
Lamiaceae/química
Solventes/química
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Antibacterianos/isolamento & purificação
Antibacterianos/toxicidade
Antifúngicos/isolamento & purificação
Antifúngicos/toxicidade
Bactérias/efeitos dos fármacos
Bactérias/crescimento & desenvolvimento
Butirilcolinesterase/metabolismo
Inibidores da Colinesterase/isolamento & purificação
Inibidores da Colinesterase/farmacologia
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/toxicidade
Fungos/efeitos dos fármacos
Fungos/crescimento & desenvolvimento
Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Inibidores de Glicosídeo Hidrolases/farmacologia
Seres Humanos
Lamiaceae/toxicidade
Inibidores de Lipoxigenase/isolamento & purificação
Inibidores de Lipoxigenase/farmacologia
Fitoterapia
Plantas Medicinais
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Cholinesterase Inhibitors); 0 (Enzyme Inhibitors); 0 (Glycoside Hydrolase Inhibitors); 0 (Lipoxygenase Inhibitors); 0 (Solvents); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  9 / 1706 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28581290
[Au] Autor:Nur-E-Alam M; Yousaf M; Ahmed S; Al-Sheddi ES; Parveen I; Fazakerley DM; Bari A; Ghabbour HA; Threadgill MD; Whatley KCL; Hoffmann KF; Al-Rehaily AJ
[Ti] Título:Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense.
[So] Source:J Nat Prod;80(6):1900-1908, 2017 Jun 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Teucrium yemense (Defl), locally known as Reehal Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen. Phytochemical investigation of the aerial parts of T. yemense yielded six new neoclerodane diterpenoids, namely fatimanol A-E (1, 2, 3, 5, and 6) and fatimanone (4), and the known teulepicephin (7). As both the Teucrium genus and the related Lamiaceae family have previously been widely reported to possess anthelmintic and antimicrobial activities, the structural and biological characterization of the seven diterpenoids was pursued. The structures of the new compounds were elucidated from their 2D NMR and MS profiles and by comparison to related compounds. The structure of fatimanol D (5) was confirmed by X-ray crystallographic analysis. The new structures contribute to the breadth of knowledge of secondary metabolites in this genus.
[Mh] Termos MeSH primário: Diterpenos/isolamento & purificação
Lamiaceae/química
Plantas Medicinais/química
Teucrium/química
[Mh] Termos MeSH secundário: Candida albicans/efeitos dos fármacos
Cristalografia por Raios X
Diterpenos/química
Escherichia coli/efeitos dos fármacos
Células Hep G2
Seres Humanos
Testes de Sensibilidade Microbiana
Conformação Molecular
Estrutura Molecular
Mycobacterium smegmatis/efeitos dos fármacos
Ressonância Magnética Nuclear Biomolecular
Pseudomonas aeruginosa/efeitos dos fármacos
Arábia Saudita
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (neoclerodane)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00188


  10 / 1706 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28569040
[Au] Autor:Yazdinezhad A; Abbasian M; Hojjat Hosseini S; Naserzadeh P; Agh-Atabay AH; Hosseini MJ
[Ad] Endereço:Department of Pharmacognosy, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
[Ti] Título:Protective effects of Ziziphora tenuior extract against chlorpyrifos induced liver and lung toxicity in rat: Mechanistic approaches in subchronic study.
[So] Source:Environ Toxicol;32(9):2191-2202, 2017 Sep.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect of ziziphora tenuior extract in 3 different doses (40, 80, 160 mg/kg) was determined. We administrated maximum tolerated dose of CPF (6.75 mg/kg) by gavage for 8 weeks (5 times in week) to male rats. Rats were sacrificed 24 h after last dose and the biochemical analysis, which confirms involvement of oxidative stress in the pathogenesis of CPF toxicity in liver including increased in lipid peroxidation, protein carbonyl content, and ROS formation, glutathione depletion, decreased of antioxidant effect via frap oxidation and cytochrome c expulsion. In addition, pathological lesions confirm the dysfunction of the organs (liver and lung). In addition, using of ziziphora extract as an antioxidant is resulted in amelioration of oxidative stress marker in liver and lung damage. In conclusion, the current study revealed that CPF toxicity is related to oxidative stress and induction of cell death signaling and cotreatment with ziziphora extract is recommended in the routine therapy for the protection against CPF induced liver and lung tissue damage.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Clorpirifos/toxicidade
Inseticidas/toxicidade
Lamiaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Glutationa/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Pulmão/efeitos dos fármacos
Pulmão/metabolismo
Masculino
Estresse Oxidativo/efeitos dos fármacos
Carbonilação Proteica
Ratos Sprague-Dawley
Testes de Toxicidade Subcrônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Insecticides); 0 (Plant Extracts); GAN16C9B8O (Glutathione); JCS58I644W (Chlorpyrifos)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22432



página 1 de 171 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde