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Pesquisa : B01.650.940.800.575.912.250.583.520.049 [Categoria DeCS]
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[PMID]:28173792
[Au] Autor:Gong H; Li S; He L; Kasimu R
[Ad] Endereço:Postdoctoral research station of college of pharmacy, Xinjiang Medical University, Xinshi District, No. 393 Xinyi Road, Urumqi, Xinjiang, People's Republic of China.
[Ti] Título:Microscopic identification and in vitro activity of Agastache rugosa (Fisch. et Mey) from Xinjiang, China.
[So] Source:BMC Complement Altern Med;17(1):95, 2017 Feb 07.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Agastache rugosa is well-known as a common traditional Chinese medicine, which have relieving summer-heat, analgesic and antipyretic effects, have long been used as folkloristic remedy in the treatment of several infectious diseases, anti-inflammatory, and for its antibacterial properties. Considering the lack of available data on the morphology, anatomy and in vitro activity of A. rugosa, the goal of the present study was to carry out the microscopic identification of its aerial parts and in vitro activity research as a contribution to the quality control and reasonable utilization involving A. rugosa. METHODS: The present study was (a) to describe the microscopic identification with usual light and scanning electron microtechniques of A. rugosa, collected from Xinjiang Region; (b) based on previous research on the essential oil constituents among different parts of A. rugosa from Xinjiang by GC-MS method, to evaluate its antibacterial effect and cell viabilitity assay. RESULTS: The microscopic identification of botanical material showed some typical structure. The essential oils from the dried flower (EOF) and leaves (EOL) of A. rugosa were 0.29% and 0.57% (w/w), respectively. The in vitro antibacterial activities showed strong inhibition against S.aureus, E. coli of EOF; strong inhibition against E. coli of EOL. Based GC-MS analysis, the MTT assay showed a dose and time-dependent increase in damage for gastric cancer cell line SGC-7901. CONCLUSIONS: The results of this work, based on an extensive analytical characterization of the EOF and EOL chemical composition, compared with other origins, showed A. rugosa possessed antibacterial and cytotoxicity properties activities, which need much additional work to open up new biomedical application of these components.
[Mh] Termos MeSH primário: Agastache
Antibacterianos/farmacologia
Fitoterapia
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Antineoplásicos/química
Antineoplásicos/farmacologia
Antineoplásicos/uso terapêutico
Linhagem Celular Tumoral/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Medicina Tradicional Chinesa
Testes de Sensibilidade Microbiana
Componentes Aéreos da Planta/anatomia & histologia
Óleos Vegetais/química
Staphylococcus aureus/efeitos dos fármacos
Neoplasias Gástricas/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents); 0 (Plant Oils)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1605-7


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[PMID]:28166786
[Au] Autor:Cao P; Xie P; Wang X; Wang J; Wei J; Kang WY
[Ad] Endereço:Institute of Chinese Materia Medica, Henan University, Kaifeng, 475004, China.
[Ti] Título:Chemical constituents and coagulation activity of Agastache rugosa.
[So] Source:BMC Complement Altern Med;17(1):93, 2017 Feb 06.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In the Chinese traditional medicine, plant of Agastache rugosa (Fisch. & C.A. Mey.) Kuntze (A. rugosa) has been used to treat nausea, vomiting and dispel damp. However, currently, few reports about the chemical constituents, especially the non-volatile components of A. rugosa are available. METHODS: Through separation with various column chromatographies to elucidate the chemical constituents of A. rugosa, the biological activities of the major constituents were investigated. The extracts and main constituents of A. rugosa were evaluated for their anticoagulant effects by assaying the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) in vitro. RESULTS: Seven known compounds (namely compounds 1-7) were isolated from the aerial parts of A. rugosa. They were identified as methyl hexadecanoate (1), ß-sitosterol (2), acacetin (3), ursolic acid (4), apigenin (5), protocatechuic acid (6) and tilianin (7), respectively. Compounds 1 and 6 were isolated from the genus Agastache for the first time, and compound 4 was obtained from the plants for the first time. The results showed that the extract of A. rugosa had a significant procoagulant activity by shortening the time of PT (P < 0.001) and increasing FIB content (P < 0.001), as compared with Vitamin K . While its major constituents acacetin and tilianin exhibited significant anticoagulant activities by prolonging the times of PT, APTT, TT and reducing FIB content (P < 0.001), as compared with blank control group. CONCLUSIONS: The total extract of A. rugosa possessed significant procoagulant activity, while its main components, acacetin and tilianin possessed significant anticoagulant activities. Further investigation should be pursued to find out the bioactivity components responsible for the procoagulant action of the plant.
[Mh] Termos MeSH primário: Agastache
Anticoagulantes/farmacologia
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anticoagulantes/química
Cromatografia
Fibrinogênio/efeitos dos fármacos
Seres Humanos
Tempo de Tromboplastina Parcial
Componentes Aéreos da Planta
Extratos Vegetais/química
Coelhos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Plant Extracts); 9001-32-5 (Fibrinogen)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1592-8


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[PMID]:27988399
[Au] Autor:Ventura-Martínez R; Rodríguez R; González-Trujano ME; Ángeles-López GE; Déciga-Campos M; Gómez C
[Ad] Endereço:Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad Universitaria, Coyoacán, México, D.F. 04510, México. Electronic address: rventuram7@hotmail.com.
[Ti] Título:Spasmogenic and spasmolytic activities of Agastache mexicana ssp. mexicana and A. mexicana ssp. xolocotziana methanolic extracts on the guinea pig ileum.
[So] Source:J Ethnopharmacol;196:58-65, 2017 Jan 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Agastache mexicana has been used in traditional medicine for relief of abdominal pain and treatment of other diseases. Two subspecies have been identified: A. mexicana ssp. mexicana (AMM) and A. mexicana ssp. xolocotziana (AMX) and both are used traditionally without distinction or in combination. AIM OF THE STUDY: To determine the effect of methanol extracts of A. mexicana ssp. mexicana and A. mexicana ssp. xolocotziana on gut motility and their possible mechanism of action. MATERIALS AND METHODS: The effect of AMM and AMX methanol extracts were tested on the spontaneous activity in the isolated guinea pig ileum and on tissues pre-contracted with KCl, electrical field stimulation (EFS) or ACh. In addition, the possible mechanism of action of each subspecies on gut motility was analyzed in the presence of hexametonium, indomethacin, L-NAME, verapamil, atropine or pyrylamine. A comparative chromatographic profile of these extracts was also done to indicate the most abundant flavonoids presents in methanol extracts of both subspecies. RESULTS: AMM, but not AMX, induced a contractile effect in the guinea pig ileum. This spasmogenic effect was partially inhibited by atropine, antagonist of muscarinic receptors; and pyrilamine, antagonist of H receptors. In contrast, AMX, but not AMM, diminished the contractions induced by KCl, EFS or ACh. The spasmolytic activity of AMX was partially inhibited by hexamethonium, ganglionic blocker; and indomethacin, inhibitor of the synthesis of prostaglandins; but not by L-NAME, inhibitor of nitric oxide synthase. In addition, AMX diminished the maximal contraction induced by CaCl in a calcium-free medium. Chromatographic analyses of these methanol extracts showed the presence of acacetin and tilanin in both. CONCLUSIONS: These results suggest that in folk medicine only AMX should be used as spasmolytic, and not in combination with AMM as traditionally occurs, due to the spasmogenic effects of the latter. In addition, activation of nicotinic receptors, prostaglandins and calcium channels, but not nitric oxide mechanisms, could be responsible for the spasmolytic activity of AMX. On the other hand, release of ACh and histamine could be involved in the spasmogenic effect induced by AMM. Acacetin and tilanin are present in methanol extracts of both subspecies and both flavonoids were more abundant in AMX than AMM. Our findings contribute to the validation of the traditional use of Agastache mexicana in relieving gastrointestinal disorders, but indicate that the subspecie that should be used for this effect is A. mexicana ssp. xolocotziana.
[Mh] Termos MeSH primário: Agastache
Íleo/efeitos dos fármacos
Parassimpatolíticos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Flavonas/análise
Flavonas/farmacologia
Flavonoides/análise
Flavonoides/farmacologia
Flores
Glicosídeos/análise
Glicosídeos/farmacologia
Cobaias
Íleo/fisiologia
Técnicas In Vitro
Masculino
Metanol/química
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Músculo Liso/fisiologia
Parassimpatolíticos/análise
Extratos Vegetais/análise
Solventes/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavones); 0 (Flavonoids); 0 (Glycosides); 0 (Parasympatholytics); 0 (Plant Extracts); 0 (Solvents); 0 (tilianin); KWI7J0A2CC (acacetin); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE


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[PMID]:27927103
[Au] Autor:Navarrete A; Ávila-Rosas N; Majín-León M; Balderas-López JL; Alfaro-Romero A; Tavares-Carvalho JC
[Ad] Endereço:a Departamento de Farmacia, Facultad de Química , Universidad Nacional Autónoma de México Ciudad Universitaria , Coyoacán , Ciudad de México , México.
[Ti] Título:Mechanism of action of relaxant effect of Agastache mexicana ssp.mexicana essential oil in guinea-pig trachea smooth muscle.
[So] Source:Pharm Biol;55(1):96-100, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Agastache mexicana ssp. mexicana (Kunth) Lint & Epling (Lamiaceae), popularly known as 'toronjil morado', is used in Mexican traditional medicine for the treatment of several diseases such as hypertension, anxiety and respiratory disorders. OBJECTIVE: This study investigates the relaxant action mechanism of A. mexicana ssp. mexicana essential oil (AMEO) in guinea-pig isolated trachea model. MATERIALS AND METHOD: AMEO was analyzed by GC/MS. The relaxant effect of AMEO (5-50 µg/mL) was tested in guinea-pig trachea pre-contracted with carbachol (3 × 10 M) or histamine (3 × 10 M) in the presence or absence of glibenclamide (10 M), propranolol (3 × 10 M) or 2',5'-dideoxyadenosine (10 M). The antagonist effect of AMEO (10-300 µg/mL) against contractions elicited by carbachol (10 -10 M), histamine (10 -10 M) or calcium (10-300 µg/mL) was evaluated. RESULTS: Essential oil composition was estragole, d-limonene and linalyl anthranilate. AMEO relaxed the carbachol (EC = 18.25 ± 1.03 µg/mL) and histamine (EC = 13.3 ± 1.02 µg/mL)-induced contractions. The relaxant effect of AMEO was not modified by the presence of propranolol, glibenclamide or 2',5'-dideoxyadenosine, suggesting that effect of AMEO is not related to ß -adrenergic receptors, ATP-sensitive potassium channels or adenylate cyclase activation. AMEO was more potent to antagonize histamine (pA ' = -1.507 ± 0.122) than carbachol (pA ' = -2.180 ± 0.357). Also, AMEO antagonized the calcium chloride-induced contractions. CONCLUSION: The results suggest that relaxant effect of AMEO might be due to blockade of calcium influx in guinea-pig trachea smooth muscle. It is possible that estragole and d-limonene could contribute majority in the relaxant effect of AMEO.
[Mh] Termos MeSH primário: Agastache/química
Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Relaxamento Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
Traqueia/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Broncodilatadores/isolamento & purificação
Sinalização do Cálcio/efeitos dos fármacos
Relação Dose-Resposta a Droga
Cromatografia Gasosa-Espectrometria de Massas
Cobaias
Técnicas In Vitro
Masculino
Músculo Liso/metabolismo
Óleos Voláteis/isolamento & purificação
Fitoterapia
Componentes Aéreos da Planta
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Traqueia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Oils, Volatile); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE


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[PMID]:27579986
[Au] Autor:Oh Y; Lim HW; Huang YH; Kwon HS; Jin CD; Kim K; Lim CJ
[Ad] Endereço:Department of Biological Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.
[Ti] Título:Attenuating properties of Agastache rugosa leaf extract against ultraviolet-B-induced photoaging via up-regulating glutathione and superoxide dismutase in a human keratinocyte cell line.
[So] Source:J Photochem Photobiol B;163:170-6, 2016 Oct.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Agastache rugosa Kuntze, known as a Korean mint, is an herbal medicine that has been used for the treatment of diverse kinds of symptoms in traditional medicine. This work was undertaken to assess the protective properties of A. rugosa leaves against UV-B-induced photoaging in HaCaT keratinocytes. They were evaluated via analyzing reactive oxygen species (ROS), promatrix metalloproteinase-2 (proMMP-2) and -9 (proMMP-9), total glutathione (GSH), total superoxide dismutase (SOD), cellular viability, flavonoid content and in vitro radical scavenging activity. Total flavonoid content of ARE, a hot water extract of A. rugosa leaves, was 22.8±7.6mg of naringin equivalent/g ARE. ARE exhibited ABTS(+) radical scavenging activity with an SC50 of 836.9µg/mL. ARE attenuated the UV-B-induced ROS generation. It diminished the UV-B-induced elevation of proMMP-2 and -9 at both activity and protein levels. On the contrary, ARE was able to enhance the UV-B-reduced total GSH and total SOD activity levels. ARE, at the used concentrations, was unable to interfere with the cellular viabilities of HaCaT keratinocytes under UV-B irradiation. Taken together, ARE possesses a protective potential against UV-B-induced photoaging in HaCaT keratinocytes, possibly based upon up-regulating antioxidant components, including total GSH and SOD. These findings reasonably suggest the use of A. rugosa leaves as a photoprotective resource in manufacturing functional cosmetics.
[Mh] Termos MeSH primário: Agastache/química
Glutationa/metabolismo
Queratinócitos/efeitos dos fármacos
Extratos Vegetais/farmacologia
Superóxido Dismutase/metabolismo
Raios Ultravioleta/efeitos adversos
Regulação para Cima/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos da radiação
Senescência Celular/efeitos dos fármacos
Senescência Celular/efeitos da radiação
Flavonoides/metabolismo
Seres Humanos
Queratinócitos/citologia
Queratinócitos/metabolismo
Queratinócitos/efeitos da radiação
Metaloproteinase 2 da Matriz/biossíntese
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/biossíntese
Metaloproteinase 9 da Matriz/metabolismo
Folhas de Planta/química
Espécies Reativas de Oxigênio/metabolismo
Regulação para Cima/efeitos da radiação
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 059QF0KO0R (Water); EC 1.15.1.1 (Superoxide Dismutase); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160901
[St] Status:MEDLINE


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[PMID]:27043507
[Au] Autor:Park WT; Arasu MV; Al-Dhabi NA; Yeo SK; Jeon J; Park JS; Lee SY; Park SU
[Ad] Endereço:Department of Crop Science, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea. harusarinamu@gmail.com.
[Ti] Título:Yeast Extract and Silver Nitrate Induce the Expression of Phenylpropanoid Biosynthetic Genes and Induce the Accumulation of Rosmarinic Acid in Agastache rugosa Cell Culture.
[So] Source:Molecules;21(4):426, 2016 Mar 29.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present study aimed to investigate the role of yeast extract and silver nitrate on the enhancement of phenylpropanoid pathway genes and accumulation of rosmarinic acid in Agastache rugosa cell cultures. The treatment of cell cultures with yeast extract (500 mg/L) and silver nitrate (30 mg/L) for varying times enhanced the expression of genes in the phenylpropanoid pathway and the production of rosmarinic acid. The results indicated that the expression of RAS and HPPR was proportional to the amount of yeast extract and silver nitrate. The transcript levels of HPPR under yeast extract treatment were 1.84-, 1.97-, and 2.86-fold higher than the control treatments after 3, 6, and 12 h, respectively, whereas PAL expression under silver nitrate treatment was 52.31-fold higher than in the non-treated controls after 24 h of elicitation. The concentration of rosmarinic acid was directly proportional to the concentration of the applied elicitors. Yeast extract supplementation documented the highest amount of rosmarinic acid at 4.98 mg/g, whereas silver nitrate addition resulted in a comparatively lower amount of rosmarinic acid at 0.65 mg/g. In conclusion, addition of yeast extract to the cell cultures enhanced the accumulation of rosmarinic acid, which was evidenced by the expression levels of the phenylpropanoid biosynthetic pathway genes in A. rugosa.
[Mh] Termos MeSH primário: Agastache/metabolismo
Cinamatos/metabolismo
Depsídeos/metabolismo
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Agastache/efeitos dos fármacos
Agastache/genética
Vias Biossintéticas/efeitos dos fármacos
Técnicas de Cultura de Células
Cinamatos/química
Depsídeos/química
Células Vegetais/efeitos dos fármacos
Células Vegetais/metabolismo
Proteínas de Plantas/biossíntese
Proteínas de Plantas/genética
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/metabolismo
Nitrato de Prata/farmacologia
Leveduras/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cinnamates); 0 (Depsides); 0 (Plant Proteins); 95IT3W8JZE (Silver Nitrate); MQE6XG29YI (rosmarinic acid)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE


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[PMID]:26094749
[Au] Autor:Desta KT; Kim GS; Kim YH; Lee WS; Lee SJ; Jin JS; Abd El-Aty AM; Shin HC; Shim JH; Shin SC
[Ad] Endereço:Department of Chemistry and Research Institute of Life Sciences, Gyeongsang National University, Jinju, 660-701, Republic of Korea.
[Ti] Título:The polyphenolic profiles and antioxidant effects of Agastache rugosa Kuntze (Banga) flower, leaf, stem and root.
[So] Source:Biomed Chromatogr;30(2):225-31, 2016 Feb.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Agastache rugosa Kuntze (Korean mint) is used as a spice and in folk medicine in East Asia. The present study identified a total of 18 polyphenols from the flower, leaf, stem and roots of this plant using high-performance liquid chromatography-tandem mass spectrometry. Fourteen of these compounds had not previously been identified in these plant tissues. Each polyphenol was validated in comparison with external calibration curves constructed using structurally related compounds, with determination coefficients >0.9993. The limits of detection and quantification were 0.092-0.650 and 0.307-2.167 mg/L, respectively. Recoveries of 61.92-116.44% were observed at two spiking levels, with 0.91-11% precision, expressed as relative standard deviation (except anthraquinone spiked at 10 mg/L). Hydroxycinnamic acid was the most abundant compound in the root, while the flowers showed the highest total flavonoid level. Antioxidant activities, determined in terms of reducing power, Fe(2+) chelating activity and the radical scavenging activities using α,α-diphenyl-ß-picrylhydrazyl and 2-2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, increased in a concentration-dependent manner; the highest activity was identified in the stems, followed by leaves > flowers > roots. These findings indicate that A. rugosa is a good source of bioactive compounds and can be used as a functional food.
[Mh] Termos MeSH primário: Agastache/química
Antioxidantes/análise
Antioxidantes/química
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Compostos de Bifenilo/metabolismo
Cromatografia Líquida
Flavonoides
Fitoterapia
Picratos/metabolismo
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150623
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3539


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[PMID]:26530776
[Au] Autor:Wang X; Perumalsamy H; Kwon HW; Na YE; Ahn YJ
[Ad] Endereço:Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea.
[Ti] Título:Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.
[So] Source:Sci Rep;5:16127, 2015 Nov 04.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The human ß-amyloid (Aß) cleaving enzyme (BACE-1) is a target for Alzheimer's disease (AD) treatments. This study was conducted to determine if acacetin extracted from the whole Agastache rugosa plant had anti-BACE-1 and behavioral activities in Drosophila melanogaster AD models and to determine acacetin's mechanism of action. Acacetin (100, 300, and 500 µM) rescued amyloid precursor protein (APP)/BACE1-expressing flies and kept them from developing both eye morphology (dark deposits, ommatidial collapse and fusion, and the absence of ommatidial bristles) and behavioral (motor abnormalities) defects. The reverse transcription polymerase chain reaction analysis revealed that acacetin reduced both the human APP and BACE-1 mRNA levels in the transgenic flies, suggesting that it plays an important role in the transcriptional regulation of human BACE-1 and APP. Western blot analysis revealed that acacetin reduced Aß production by interfering with BACE-1 activity and APP synthesis, resulting in a decrease in the levels of the APP carboxy-terminal fragments and the APP intracellular domain. Therefore, the protective effect of acacetin on Aß production is mediated by transcriptional regulation of BACE-1 and APP, resulting in decreased APP protein expression and BACE-1 activity. Acacetin also inhibited APP synthesis, resulting in a decrease in the number of amyloid plaques.
[Mh] Termos MeSH primário: Doença de Alzheimer/patologia
Comportamento Animal/efeitos dos fármacos
Olho/patologia
Flavonas/farmacologia
[Mh] Termos MeSH secundário: Agastache/química
Agastache/metabolismo
Doença de Alzheimer/metabolismo
Secretases da Proteína Precursora do Amiloide/antagonistas & inibidores
Secretases da Proteína Precursora do Amiloide/genética
Secretases da Proteína Precursora do Amiloide/metabolismo
Peptídeos beta-Amiloides/metabolismo
Precursor de Proteína beta-Amiloide/genética
Precursor de Proteína beta-Amiloide/metabolismo
Animais
Animais Geneticamente Modificados/metabolismo
Modelos Animais de Doenças
Drosophila/metabolismo
Ingestão de Alimentos/efeitos dos fármacos
Olho/efeitos dos fármacos
Olho/metabolismo
Flavonas/química
Transferência Ressonante de Energia de Fluorescência
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Longevidade/efeitos dos fármacos
Masculino
Ácido Oleanólico/química
Ácido Oleanólico/farmacologia
Fenótipo
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Amyloid beta-Protein Precursor); 0 (Flavones); 0 (Triterpenes); 6SMK8R7TGJ (Oleanolic Acid); E233J88OHQ (maslinic acid); EC 3.4.- (Amyloid Precursor Protein Secretases); KWI7J0A2CC (acacetin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151105
[St] Status:MEDLINE
[do] DOI:10.1038/srep16127


  9 / 35 MEDLINE  
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[PMID]:25978436
[Au] Autor:Moon H; Kim MJ; Son HJ; Kweon HJ; Kim JT; Kim Y; Shim J; Suh BC; Rhyu MR
[Ad] Endereço:Research Group of Food Functionality, Korea Food Research Institute, Bundang-gu, Sungnam-si, Gyeonggi-do, Republic of Korea.
[Ti] Título:Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa.
[So] Source:PLoS One;10(5):e0127060, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified methyl syringate as an hTRPA1 agonist with efficacy against gastric emptying. The aim of this study was to find hTRPA1 and/or hTRPV1 activators in Agastache rugosa (Fisch. et Meyer) O. Kuntze (A.rugosa), commonly known as Korean mint to improve hTRPA1-related phenomena. An extract of the stem and leaves of A.rugosa (Labiatae) selectively activated hTRPA1 and hTRPV1. We next investigated the effects of commercially available compounds found in A.rugosa (acacetin, 4-allylanisole, p-anisaldehyde, apigenin 7-glucoside, L-carveol, ß-caryophyllene, trans-p-methoxycinnamaldehyde, methyl eugenol, pachypodol, and rosmarinic acid) on cultured hTRPA1- and hTRPV1-expressing cells. Of the ten compounds, L-carveol, trans-p-methoxycinnamaldehyde, methyl eugenol, 4-allylanisole, and p-anisaldehyde selectively activated hTRPA1, with EC50 values of 189.1±26.8, 29.8±14.9, 160.2±21.9, 1535±315.7, and 546.5±73.0 µM, respectively. The activities of these compounds were effectively inhibited by the hTRPA1 antagonists, ruthenium red and HC-030031. Although the five active compounds showed weaker calcium responses than allyl isothiocyanate (EC50=7.2±1.4 µM), our results suggest that these compounds from the stem and leaves of A.rugosa are specific and selective agonists of hTRPA1.
[Mh] Termos MeSH primário: Agastache/química
Proteínas do Tecido Nervoso/agonistas
Canais de Receptores Transientes de Potencial/agonistas
[Mh] Termos MeSH secundário: Acetanilidas/farmacologia
Anisóis/farmacologia
Benzaldeídos/farmacologia
Canais de Cálcio
Linhagem Celular
Eugenol/análogos & derivados
Eugenol/farmacologia
Células HEK293
Seres Humanos
Monoterpenos/farmacologia
Proteínas do Tecido Nervoso/antagonistas & inibidores
Extratos Vegetais/farmacologia
Folhas de Planta/química
Caules de Planta/química
Purinas/farmacologia
Rutênio Vermelho/farmacologia
Sesquiterpenos/farmacologia
Canal de Cátion TRPA1
Canais de Cátion TRPV/agonistas
Canais de Receptores Transientes de Potencial/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide); 0 (Acetanilides); 0 (Anisoles); 0 (Benzaldehydes); 0 (Calcium Channels); 0 (Monoterpenes); 0 (Nerve Tissue Proteins); 0 (Plant Extracts); 0 (Purines); 0 (Sesquiterpenes); 0 (TRPA1 Cation Channel); 0 (TRPA1 protein, human); 0 (TRPV Cation Channels); 0 (TRPV1 protein, human); 0 (Transient Receptor Potential Channels); 11103-72-3 (Ruthenium Red); 29T9VA6R7M (methyleugenol); 3T8H1794QW (Eugenol); 99-48-9 (carveol); 9NIW07V3ET (estragole); 9PA5V6656V (4-anisaldehyde); BHW853AU9H (caryophyllene)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150516
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0127060


  10 / 35 MEDLINE  
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[PMID]:25510964
[Au] Autor:Yamani H; Mantri N; Morrison PD; Pang E
[Ti] Título:Analysis of the volatile organic compounds from leaves, flower spikes, and nectar of Australian grown Agastache rugosa.
[So] Source:BMC Complement Altern Med;14:495, 2014 Dec 15.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The foraging choices of honey bees are influenced by many factors, such as floral aroma. The composition of volatile compounds influences the bioactivity of the aromatic plants and honey produced from them. In this study, Agastache rugosa was evaluated as part of a project to select the most promising medicinal plant species for production of bioactive honey. METHODS: Headspace solid-phase microextraction HS-SPME /GC-MS was optimized to identify the volatile bioactive compounds in the leaves, flower spikes, and for the first time, the flower nectar of Australian grown A. rugosa. RESULTS: Methyl chavicol (= estragole) was the predominant headspace volatile compound in the flowers with nectar, flower spikes, and leaves, with a total of 97.16%, 96.74% and 94.35%, respectively. Current results indicate that HS-SPME/GC-MS could be a useful tool for screening estragole concentration in herbal products. CONCLUSION: Recently, estragole was suspected to be carcinogenic and genotoxic, according to the European Union Committee on Herbal Medicinal Products. Further studies are needed on safe daily intake of Agastache as herbal tea or honey, as well as for topical uses.
[Mh] Termos MeSH primário: Agastache/química
Anisóis/análise
Mel/análise
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Néctar de Plantas/química
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Agastache/efeitos adversos
Animais
Anisóis/efeitos adversos
Austrália
Abelhas
Flores/química
Cromatografia Gasosa-Espectrometria de Massas/métodos
Mel/efeitos adversos
Seres Humanos
Extratos Vegetais/efeitos adversos
Folhas de Planta/química
Plantas Medicinais/química
Microextração em Fase Sólida/métodos
Compostos Orgânicos Voláteis/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anisoles); 0 (Plant Extracts); 0 (Plant Nectar); 0 (Volatile Organic Compounds); 9NIW07V3ET (estragole)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:151028
[Lr] Data última revisão:
151028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141217
[St] Status:MEDLINE
[do] DOI:10.1186/1472-6882-14-495



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