Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.520.098 [Categoria DeCS]
Referências encontradas : 62 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 7 ir para página                  

  1 / 62 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27989668
[Au] Autor:Li S; Sun X; Li Y; Liu F; Ma J; Tong L; Su G; Xu J; Ohizumi Y; Lee D; Guo Y
[Ad] Endereço:State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
[Ti] Título:Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS.
[So] Source:Bioorg Med Chem Lett;27(3):670-674, 2017 02 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2-13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein.
[Mh] Termos MeSH primário: Callicarpa/química
Diterpenos Abietanos/química
Diterpenos/química
Óxido Nítrico/metabolismo
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Callicarpa/metabolismo
Linhagem Celular
Dicroísmo Circular
Diterpenos/isolamento & purificação
Diterpenos/farmacologia
Diterpenos Abietanos/isolamento & purificação
Diterpenos Abietanos/farmacologia
Espectroscopia de Ressonância Magnética
Camundongos
Microglia/citologia
Microglia/efeitos dos fármacos
Microglia/metabolismo
Conformação Molecular
Simulação de Acoplamento Molecular
Óxido Nítrico Sintase Tipo II/química
Óxido Nítrico Sintase Tipo II/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
Estrutura Terciária de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Diterpenes); 0 (Diterpenes, Abietane); 0 (kwangpene A); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE


  2 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27650129
[Au] Autor:Feng SX; Yi B; Zhang M; Xu J; Lin H; Xu WT
[Ad] Endereço:a Key Laboratory of South Subtropical Plant Diversity , Fairy Lake Botanical Garden, Shenzhen & Chinese Academy of Sciences , Shenzhen , China.
[Ti] Título:Iridoid glycosides from Callicarpa nudiflora Hook.
[So] Source:Nat Prod Res;31(2):181-189, 2017 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four new iridoid glycoside derivatives (1-4), along with ten known iridoid glycosides (5-14), were isolated from Callicarpa nudiflora Hook et Arn. The structure of the new iridoid glycosides was elucidated as 5″-methoxy-ampicoside (1), 6″-O-trans-caffeoylcatalpol (2), 6″-O-trans-feruloylcatalpol (3) and 3″-methoxy-agnucastoside C (4) on the basis of spectroscopic analysis. Compounds 1-11 were reported from this plant for the first time. The cytotoxic activity of the isolated compounds against human cervical carcinoma Hela cells and ovarian carcinoma HeyA8 cells was evaluated using the microculture tetrazolium assay. Compounds 4, 5, 8, 12 and 13 showed cytotoxic activity against the Hela cell line with IC values of 25.3, 48.1, 17.3, 38.3 and 28.2 µM, respectively. While only compound 8 showed cytotoxicity against the HeyA8 cell line, with an IC of 35.5 µM.
[Mh] Termos MeSH primário: Callicarpa/química
Glicosídeos Iridoides/isolamento & purificação
[Mh] Termos MeSH secundário: Antineoplásicos/isolamento & purificação
Antineoplásicos/farmacologia
Morte Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Seres Humanos
Glicosídeos Iridoides/química
Glicosídeos Iridoides/farmacologia
Estrutura Molecular
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Iridoid Glycosides)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160922
[St] Status:MEDLINE


  3 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27491749
[Au] Autor:Xu J; Li S; Sun X; Ma J; Liu F; Tong L; Lee D; Ohizumi Y; Tuerhong M; Guo Y
[Ad] Endereço:State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
[Ti] Título:Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects.
[So] Source:Fitoterapia;113:151-7, 2016 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1-3), callipenes A-C, and eleven known analogues (4-14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells.
[Mh] Termos MeSH primário: Callicarpa/química
Diterpenos Abietanos/química
Diterpenos/química
Óxido Nítrico/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Diterpenos/isolamento & purificação
Diterpenos Abietanos/isolamento & purificação
Camundongos
Estrutura Molecular
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (Diterpenes, Abietane); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE


  4 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26938160
[Au] Autor:Liu J; Gu Z; Yao S; Zhang Z; Chen B
[Ad] Endereço:Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China; College of Chemistry and Chemical Engineering, University of South China, Hengyang 421
[Ti] Título:Rapid analysis of Callicarpa L. using direct spray ionization mass spectrometry.
[So] Source:J Pharm Biomed Anal;124:93-103, 2016 May 30.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Direct spray such as leaf spray and paper spray ionization mass spectrometry (MS) is a powerful type of ambient MS for phytochemical analysis. In this paper, direct spray MS methods to rapidly distinguish and analyze five species of Callicarpa L. have been developed. To distinguish species, leaf spray MS was employed to directly analyze leaves. A small triangular leaf sample was wetted with 15 µL of spray solvent and a high DC voltage was then simply applied to the wet leaf sample, which was positioned in front of the inlet of a mass spectrometer to produce electrospray ionization. The MS signals of phenylpropanoid glycosides, i.e. forsythiaside B, poliumoside, verbascoside in leaves could be sensitively detected. The content characteristics of the phenylpropanoid glycosides in five species including Callicarpae kwangtungensis Folium, Callicarpae macrophyllae Folium, Callicarpa nudiflora Folium, Callicarpae formosanae Folium, Callicarpa longissima Folium could be used to distinguish them, then the mass spectra of the Callicarpa L. samples were analyzed using principal component analysis(PCA) or partial least squares-discriminant analysis(PLS-DA). For the rapid semi-quantitative analysis, of phenylpropanoid glycosides in leaves, paper spray MS was employed to determine phenylpropanoid glycosides in the extracts of Callicarpa L. leaves. Ginsenoside Rg1 was selected as an internal standard (I.S.). The calibration curves were constructed through ratios of target ion abundance to I.S. ion abundance vs. concentration of targets. The linearity range was 8-250 µg/mL (R(2)=0.9947) for forsythiaside B, 9-280 µg/mL (R(2)=0.9939) for verbascoside, and 9-260 µg/mL (R(2)=0.9917) for poliumoside, respectively. The limit of detection (LOD) was 1 µg/mL, 0.5 µg/mL and 1 µg/mL for forsythiaside B, verbascoside, and poliumoside, respectively.
[Mh] Termos MeSH primário: Callicarpa/química
Espectrometria de Massas por Ionização por Electrospray/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160304
[St] Status:MEDLINE


  5 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26507813
[Au] Autor:Luo YH; Fu HZ; Huang B; Chen WK; Ma SC
[Ad] Endereço:a Jiangxi Provincial Institute for Drug Control, Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality , Nanchang 330029 , China.
[Ti] Título:Hepatoprotective iridoid glucosides from Callicarpa nudiflora.
[So] Source:J Asian Nat Prod Res;18(3):274-9, 2016.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new iridoid glucosides, callicoside A (1) and callicoside B (2), were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated by means of spectroscopic methods and chemical evidences. In an in vitro bioassay, compound 1 showed pronounced hepatoprotective activity against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
[Mh] Termos MeSH primário: Callicarpa/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Glucosídeos Iridoides/isolamento & purificação
Glucosídeos Iridoides/farmacologia
Fígado/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Medicamentos de Ervas Chinesas/química
Galactosamina/farmacologia
Glucosídeos Iridoides/química
Fígado/citologia
Estrutura Molecular
Folhas de Planta/química
Ratos
Ratos Endogâmicos F344
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Iridoid Glucosides); 0 (callicoside A); 0 (callicoside B); 7535-00-4 (Galactosamine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160325
[Lr] Data última revisão:
160325
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151029
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2015.1074572


  6 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26267810
[Au] Autor:Yamahara M; Sugimura K; Kumagai A; Fuchino H; Kuroi A; Kagawa M; Itoh Y; Kawahara H; Nagaoka Y; Iida O; Kawahara N; Takemori H; Watanabe H
[Ad] Endereço:Institute for Molecular Science of Medicine, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
[Ti] Título:Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.
[So] Source:J Nat Med;70(1):28-35, 2016 Jan.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Cosmetic industries focus on developing materials and resources that regulate skin pigmentation. Melanin, the major pigment in human skin, protects the skin against damage from ultraviolet light. An ethanolic extract of the leaves of Callicarpa longissima inhibits melanin production in B16F10 mouse melanoma cells by suppressing microphthalmia-associated transcription factor (MITF) gene expression. Following purification and analysis using liquid chromatography-mass spectrometry (LC-MS), NMR, and biochemical assays, carnosol was determined to be responsible for the major inhibitory effect of the C. longissima extract on melanin production. Carnosol is an oxidative product of carnosic acid, whose presence in the extract was also confirmed by an authentic reference. The carnosol and carnosic acid content in the extract was approximately 16% (w/w). These results suggest that C. longissima is a novel, useful, and attractive source of skin-whitening agents.
[Mh] Termos MeSH primário: Callicarpa/química
Diferenciação Celular/efeitos dos fármacos
Diterpenos Abietanos/farmacologia
Melaninas/biossíntese
Melanoma Experimental/metabolismo
Fator de Transcrição Associado à Microftalmia/biossíntese
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Cromatografia Líquida
Diterpenos Abietanos/química
Diterpenos Abietanos/metabolismo
Expressão Gênica/efeitos dos fármacos
Seres Humanos
Espectrometria de Massas
Camundongos
Fator de Transcrição Associado à Microftalmia/genética
Preparações Clareadoras de Pele/farmacologia
Pigmentação da Pele/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Diterpenes, Abietane); 0 (Melanins); 0 (Microphthalmia-Associated Transcription Factor); 0 (Plant Extracts); 0 (Skin Lightening Preparations); 483O455CKD (carnosol); LI791SXT24 (salvin)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150813
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-015-0933-5


  7 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27356382
[Au] Autor:Ding JH; Yuan MM; Yu Y; Zhou GP
[Ti] Título:[Ethyl Acetate-Soluble Chemical Constituents from Callicarpa kwangtungensis (II)].
[So] Source:Zhong Yao Cai;38(11):2314-7, 2015 Nov.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the ethyl acetate-soluble chemical constituents of Callicarpa kwangtungensis. METHODS: The chemical constituents were isolated by column chromatography on silica gel, Sephadex LH-20 and MPLC. Their chemical structures were elucidated on the basis of special analysis. RESULTS: Eleven compounds were isolated from the ethyl acetate-soluble part of Callicarpa kwangtungensis, whose structures were elucidated as 4-methoxybenzoic acid (1), 3,4-dihydroxybenzoic acid (2), 4-hydroxy cinnamic acid(3), phenyl-ß-D-glucopyranoside (4), 3,4,5-trimethoxyphenyl-ß-D-glucopyranoside (5), 2α,3ß,22ß,23-tetrahydroxyursolic-12-en-28-oic acid (6), 2α,3ß,6ß,19α-tetrahydroxy-urs-12-en-28-O-ß-D-glucopyranoside (7), 2ß,3ß,6ß,16α-tetrahydroxy-olean-12-en-28-O-ß-D-glucopyranoside (8), (3S, 6E, 10R)-10-ß-D-glucopyranosyloxy-3,11-dihydroxy-3,7,11-trimethyldodeca-1,6-diene (9), icariside C5(10), and (2E, 6E)-10-ß-D-glucopyranosyl-1, 11-dihydroxy-3, 7, 11-trimethyldodeca-2,6-diene (11). CONCLUSION: Compounds 4 - 11are isolated from Callicarpa genus for the first time, compounds 1 - 3 are isolated from this plant for the first time.
[Mh] Termos MeSH primário: Callicarpa/química
Compostos Fitoquímicos/análise
[Mh] Termos MeSH secundário: Acetatos
Cromatografia
Compostos Fitoquímicos/isolamento & purificação
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Phytochemicals); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160630
[Lr] Data última revisão:
160630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE


  8 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27356380
[Au] Autor:Luo YH; Ma SC; Hu SR; Fu HZ; Zhou ZQ; Chen WK
[Ti] Título:[Chemical Constituents from Callicarpa nudiflora].
[So] Source:Zhong Yao Cai;38(11):2306-10, 2015 Nov.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the chemical constituents of Callicarpa nudiflora. METHODS: The chemical constituents were isolated and purified by column chromatography on silica gel, ODS, Sephadex LH-20 and MPLC. Their structures were elucidated on the basis of physicochemical properties and special analysis. RESULTS: Eleven compounds were isolated from the leaves of Callicarpa nudiflora, whose structures were elucidated as 2α,3α-dihydroxyurs-12-en-28-oic acid (1), isorhamnetin (2), 2α,3ß,19α-trihydroxyurs-12-en-28-oic acid(3), 2α,3α,19α,23-tetrahydroxyurs-12-en-28-oic acid(4), 2α,3α,19α-trihyhydroxy-olean-12-en-28-O-α-D-glucopyranoside (5), benzyl-4'-hydroxy-benzoyl-3'-O-ß-D-glucopyranoside(6) (3S,5R,6R,7E,9S)-megastigman-7-ene-3,5,6,9-tetrol(7), philonotisflavone(8), 1, 6-di-O-caffeoyl-ß-D-glucopyranoside (9), luteolin-4'-O-(6"-E-caffeoyl)-ß-D-glucopyranoside (10), and (6S, 9R)-roseoside(11). CONCLUSION: All compounds are isolated from this plant for the first time.
[Mh] Termos MeSH primário: Callicarpa/química
Compostos Fitoquímicos/análise
Folhas de Planta/química
[Mh] Termos MeSH secundário: Compostos Fitoquímicos/isolamento & purificação
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytochemicals)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160630
[Lr] Data última revisão:
160630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE


  9 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26342519
[Au] Autor:Lee JW; Shin NR; Park JW; Park SY; Kwon OK; Lee HS; Hee Kim J; Lee HJ; Lee J; Zhang ZY; Oh SR; Ahn KS
[Ad] Endereço:Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Chungju-si, Chungbuk 363-883, Republic of Korea.
[Ti] Título:Callicarpa japonica Thunb. attenuates cigarette smoke-induced neutrophil inflammation and mucus secretion.
[So] Source:J Ethnopharmacol;175:1-8, 2015 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Callicarpa japonica Thunb. (CJT) is traditionally used as an herbal remedy for the treatment of inflammatory diseases in Korea, China, and Japan. In this study, we evaluated the effects of C. japonica Thunb. (CJT) on the development of COPD using a Cigarette smoke (CS)-induced murine model and cigarette smoke condensate (CSC)-stimulated H292 cells, human pulmonary mucoepidermoid cell line. MATERIAL AND METHODS: C. japonica Thunb. was isolated from the leaves and stem of C. japonica. The methanol extract profile was obtained by UPLC Q-TOF-MS analysis. In in vivo experiment, the mice received 1h of cigarette smoke for 10 days. C. japonica Thunb. was administered to mice by oral gavage 1h before cigarette smoke exposure for 10 days. In in vitro experiment, we evaluated the effect of C. japonica Thunb. on the expression of MUC5AC and proinflammatory cytokines in H292 cells stimulated with CSC. RESULTS: CJT treatment effectively suppressed the infiltration of neutrophils, and decreased the production of ROS and the activity of neutrophil elastase in the bronchoalveolar lavage fluid (BALF) induced by CS. CJT also significantly attenuated production of proinflammatory cytokines such as IL-6 and TNF-α in the BALF, and reduced the infiltration of inflammatory cells and the production of mucus in lung tissue induced by CS. In in vitro experiments, CJT decreased the expression of MUC5AC and proinflammatory cytokines in CSC-stimulated H292 cells. Furthermore, CJT attenuated the phosphorylation of ERK induced by CSC in H292 cells. Taken together, CJT effectively reduced the neutrophil airway inflammation and mucus secretion induced by CS in murine model, and inhibited the expression of MUC5AC in CSC-stimulated H292 human lung cell line. These findings suggest that CJT has a therapeutic potential for the treatment of COPD.
[Mh] Termos MeSH primário: Callicarpa
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar/química
Líquido da Lavagem Broncoalveolar/imunologia
Linhagem Celular
Linhagem Celular Tumoral
Modelos Animais de Doenças
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Seres Humanos
Interleucina-6/imunologia
Elastase de Leucócito/metabolismo
Pulmão/efeitos dos fármacos
Pulmão/imunologia
Pulmão/patologia
Pulmão/secreção
Masculino
Camundongos Endogâmicos C57BL
Muco/secreção
Neutrófilos/efeitos dos fármacos
Neutrófilos/imunologia
Folhas de Planta
Caules de Planta
Doença Pulmonar Obstrutiva Crônica/imunologia
Doença Pulmonar Obstrutiva Crônica/metabolismo
Doença Pulmonar Obstrutiva Crônica/patologia
Espécies Reativas de Oxigênio/metabolismo
Tabaco
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (Smoke); 0 (Tumor Necrosis Factor-alpha); 0 (interleukin-6, mouse); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 3.4.21.37 (Leukocyte Elastase)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150907
[St] Status:MEDLINE


  10 / 62 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:26323147
[Au] Autor:Zheng DK; Chen WK; Ma SC; Wang J; Luo CX; Luo YH
[Ti] Título:[Study on HPLC fingerprint of Callicarpa nudiflora and determination of ten components].
[So] Source:Zhongguo Zhong Yao Za Zhi;40(9):1776-82, 2015 May.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:This study is to establish the HPLC fingerprint and determine eight components of Callicarpa nudiflora, and provide a scientific basis for the identification and quality control. The Waters sunfire C18 column (4.6 mm x 250 mm, 5 µm) was used and the detection wavelength was 330 nm . The column temperature was 30 °C. The mobile phases were acetonitrile (A) and 0.1% formic acid (B) eluting in a gradient program at a flow rate of 1.0 mL · min(-1). The chromatographic fingerprint similarity evaluation system for tradition Chinese medicine(2012) was used for analysis. C. nudiflora from different samples were of high similarity in fingerprint and the separation of ten components was good. There was an obvious difference between other samples and C. nudiflora leaves. In quantitative analysis, the ten components showed good regression(R2 > 0 999 0) with linear ranges, and their recoveries were in the range of 96.0%-105.0%. The established qualitative and quantitative methods are highly specific, simple and accurate, which can be used for the identification and quality control of C. nudiflora.
[Mh] Termos MeSH primário: Callicarpa/química
Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/análise
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/isolamento & purificação
Plantas Medicinais/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150901
[Lr] Data última revisão:
150901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150902
[St] Status:MEDLINE



página 1 de 7 ir para página                  
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde