Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.520.121 [Categoria DeCS]
Referências encontradas : 132 [refinar]
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[PMID]:28458420
[Au] Autor:Vazhayil BK; Rajagopal SS; Thangavelu T; Swaminathan G; Rajagounder E
[Ad] Endereço:Department of Pharmaceutical Chemistry, J. K. K. Nattraja College of Pharmacy, Komarapalayam, Namakkal, Tamil Nadu, India.
[Ti] Título:Neuroprotective effect of Linn. leaves extract against acute restraint stress-induced depressive-like behavioral symptoms in adult mice.
[So] Source:Indian J Pharmacol;49(1):34-41, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of this study was to study the effect of ethanol extract of (EECS) Linn. on acute restraint stress (ARS)-induced depressive-like behavior and biochemical alterations in mice. MATERIALS AND METHODS: Ethyl acetate and n-butanol fractions of EECS were analytically characterized for the flavonoid components, apigenin (API) and luteolin (LUT) by reverse-phase high-performance liquid chromatography. Behavioral tests, namely, forced-swim test and tail-suspension test were performed for assessing antidepressant-like effect and anxiolytic activity in mice. Oxidative stress parameters and biochemical alterations in mice brain tissue were also performed. STATISTICAL ANALYSIS: Expression of data was done as mean ± standard error of mean. The normally distributed data were subjected to two-way ANOVA followed by Dunnett's test. < 0.05 was considered statistically significant. RESULTS: The study showed that flavonoids, API and LUT were present in ethyl acetate and n-butanol fractions of EECS, which significantly reversed ARS-induced depressive-like behavior without affecting locomotion. EECS also attenuated oxidative damage caused by ARS. The level of norepinephrine and 5-hydroxytryptamine was also significantly restored by pretreatment with EECS for 7 days. CONCLUSION: EECS significantly alleviated ARS-induced depressive-like behavior without affecting locomotion.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Clerodendrum/química
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Cromatografia Líquida de Alta Pressão
Depressão/tratamento farmacológico
Modelos Animais de Doenças
Elevação dos Membros Posteriores
Masculino
Camundongos
Atividade Motora/efeitos dos fármacos
Fármacos Neuroprotetores/isolamento & purificação
Estresse Oxidativo/efeitos dos fármacos
Folhas de Planta
Restrição Física
Serotonina/metabolismo
Estresse Psicológico/tratamento farmacológico
Natação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Neuroprotective Agents); 0 (Plant Extracts); 333DO1RDJY (Serotonin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201028


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[PMID]:28070575
[Au] Autor:Gogoi B; Gogoi D; Silla Y; Kakoti BB; Bhau BS
[Ad] Endereço:Plant Genomic Laboratory, Medicinal Aromatic & Economic Plants (MAEP) Group, Biological Sciences & Technology Division (BSTD), CSIR-North East Institute of Science and Technology, Jorhat-785006, Assam, India. bsbhau@gmail.com bsbhau@neist.res.in.
[Ti] Título:Network pharmacology-based virtual screening of natural products from Clerodendrum species for identification of novel anti-cancer therapeutics.
[So] Source:Mol Biosyst;13(2):406-416, 2017 Jan 31.
[Is] ISSN:1742-2051
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plant-derived natural products (NPs) play a vital role in the discovery of new drug molecules and these are used for development of novel therapeutic drugs for a specific disease target. Literature review suggests that natural products possess strong inhibitory efficacy against various types of cancer cells. Clerodendrum indicum and Clerodendrum serratum are reported to have anticancer activity; therefore a study was carried out to identify selective anticancer agents from these plants species. In this report, we employed a docking weighted network pharmacological approach to understand the multi-therapeutics potentiality of C. indicum and C. serratum against various types of cancer. A library of 53 natural products derived from these plants was compiled from the literature and three dimensional space analyses were performed in order to establish the drug-likeness of the NPs library. Further, an NPs-cancer network was built based on docking. We predicted five compounds, namely apigenin 7-glucoside, hispidulin, scutellarein-7-O-beta-d-glucuronate, acteoside and verbascoside, to be potential binding therapeutics for cancer target proteins. Apigenin 7-glucoside and hispidulin were found to have maximum binding interactions (relationship) with 17 cancer drug targets in terms of docking weighted network pharmacological analysis. Hence, we used an integrative approach obtained from network pharmacology for identifying combinatorial drug actions against the cancer targets. We believe that our present study may provide important clues for finding novel drug inhibitors for cancer.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Produtos Biológicos/química
Clerodendrum/química
Simulação por Computador
Descoberta de Drogas
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/efeitos adversos
Antineoplásicos Fitogênicos/farmacocinética
Antineoplásicos Fitogênicos/farmacologia
Sítios de Ligação
Produtos Biológicos/efeitos adversos
Produtos Biológicos/farmacocinética
Produtos Biológicos/farmacologia
Domínio Catalítico
Descoberta de Drogas/métodos
Conformação Molecular
Simulação de Acoplamento Molecular
Simulação de Dinâmica Molecular
Ligação Proteica
Bibliotecas de Moléculas Pequenas
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Biological Products); 0 (Small Molecule Libraries)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1039/c6mb00807k


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[PMID]:28011378
[Au] Autor:Erukainure OL; Hafizur RM; Choudhary MI; Adhikari A; Mesaik AM; Atolani O; Banerjee P; Preissner R; Muhammad A; Islam MS
[Ad] Endereço:Nutrition and Toxicology Division, Federal Institute of Industrial Research, Lagos, Nigeria; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, School of Life Sciences, Univers
[Ti] Título:Anti-diabetic effect of the ethyl acetate fraction of Clerodendrum volubile: protocatechuic acid suppresses phagocytic oxidative burst and modulates inflammatory cytokines.
[So] Source:Biomed Pharmacother;86:307-315, 2017 Feb.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The antidiabetic effects of the ethyl acetate (EtOAc) fraction of Clerodendrum volubile leaves was investigated in this study. EtOAc extract was also fractionated to isolate the active compounds. The structure of the isolated compound (Protocatechuic acid) was established using H and C NMR spectroscopies and mass spectrometry. Protocatechuic acid was investigated for its anti-oxidative burst in polymorphonuclear neutrophils (PMNs) and macrophages. It was also docked with α-glucosidase and TNF-α. Acute treatment with EtOAc fraction of Clerodendrum volubile leaves significantly (p<0.05) decreased blood glucose level and hepatic biomarkers, and significantly (p<0.05) increased serum insulin level and ß-cell function. It had little or no effect on serum lipid profile and atherogenic indices. Protocatechuic acid significantly (p<0.05) suppressed phagocytic oxidative burst and docked well with α-glucosidase and TNF-α. These results indicate the therapeutic effect of EtOAc fraction of C. volubile on type 2 diabetes and its complications, which can be attributed to the main bioactive compound, protocatechuic acid.
[Mh] Termos MeSH primário: Acetatos/uso terapêutico
Clerodendrum
Citocinas/antagonistas & inibidores
Hidroxibenzoatos/uso terapêutico
Hipoglicemiantes/uso terapêutico
Fagócitos/efeitos dos fármacos
Explosão Respiratória/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acetatos/isolamento & purificação
Acetatos/farmacologia
Animais
Citocinas/metabolismo
Seres Humanos
Hidroxibenzoatos/isolamento & purificação
Hidroxibenzoatos/farmacologia
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/farmacologia
Mediadores da Inflamação/antagonistas & inibidores
Mediadores da Inflamação/metabolismo
Masculino
Simulação de Acoplamento Molecular
Fagócitos/metabolismo
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Ratos
Ratos Wistar
Explosão Respiratória/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Cytokines); 0 (Hydroxybenzoates); 0 (Hypoglycemic Agents); 0 (Inflammation Mediators); 0 (Plant Extracts); 36R5QJ8L4B (protocatechuic acid); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


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[PMID]:27753518
[Au] Autor:Oboh G; Ogunruku OO; Oyeleye SI; Olasehinde TA; Ademosun AO; Boligon AA
[Ad] Endereço:a Functional Food and Nutraceutical Laboratory , Department of Biochemistry, Federal University of Technology Akure , Akure , Nigeria.
[Ti] Título:Phenolic Extracts from Clerodendrum volubile Leaves Inhibit Cholinergic and Monoaminergic Enzymes Relevant to the Management of Some Neurodegenerative Diseases.
[So] Source:J Diet Suppl;14(3):358-371, 2017 May 04.
[Is] ISSN:1939-022X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the inhibitory effects of phenolic-rich extracts from Clerodendrum volubile leaves on cholinergic [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)] and monoaminergic [monoamine oxidase (MAO)] enzymes' activities and pro-oxidants [Fe and quinolinic acid-(QA)] induced lipid peroxidation in rats brain homogenates in vitro. Free phenolic extracts (FPE) and bound phenolic extracts (BPE) were obtained via solvent extraction, and the total phenol and flavonoid contents were evaluated. The phenolic constituents of the extracts were also determined using high performance liquid chromatography coupled with diode array detector (HPLC-DAD). Our findings revealed that FPE had higher AChE (2.06 µg/mL), BChE (2.79 µg/mL), and MAO (2.81 µg/mL) inhibitory effects than BPE [AChE, 2.80 µg/mL; BChE, 3.40 µg/mL; MAO, 3.39 µg/mL]. Furthermore, FPE also had significantly (P < 0.05) higher inhibitory effects on Fe and QA-induced lipid peroxidation compared to BPE. FPE (162.61 mg GAE/g) had higher total phenol content than BPE. However, BPE (18.65 mg QE/g) had significantly higher total flavonoid content than FPE (13.32 mg QE/g). Phenolic acids (such as gallic acid, catechin, chlorogenic, caffeic, ellagic, p-Coumaric acids) and flavonoids (catechins, rutin and quercetin) were present in both extracts. This study revealed that the enzymes' inhibitory activities and antioxidant potentials of phenolic-rich extracts from C. volubile could be part of the mechanism of actions behind its use for memory/cognitive function as obtained in folklore. However, FPE exhibited significantly higher enzymes, inhibitory and antioxidant potentials than BPE.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Clerodendrum/química
Doenças Neurodegenerativas/tratamento farmacológico
Fenol/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Acetilcolinesterase/efeitos dos fármacos
Animais
Encéfalo/enzimologia
Butirilcolinesterase/efeitos dos fármacos
Inibidores da Colinesterase/farmacologia
Cromatografia Líquida de Alta Pressão
Flavonoides/análise
Flavonoides/farmacologia
Peroxidação de Lipídeos/efeitos dos fármacos
Doenças Neurodegenerativas/enzimologia
Fenol/análise
Ratos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Flavonoids); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 339NCG44TV (Phenol); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27595160
[Au] Autor:Nandi S; Ukil B; Roy S; Kundu S; Lyndem LM
[Ad] Endereço:a Department of Zoology , VisvaBharati University , Santiniketan , West Bengal , India.
[Ti] Título:Anthelmintic efficacy of Clerodendrum viscosum on fowl tapeworm Raillietina tetragona.
[So] Source:Pharm Biol;55(1):1401-1406, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Clerodendrum viscosum Vent. (Verbenaceae) is a shrub, widely used amongst the natives of India against various diseases. OBJECTIVE: Crude extract of the plant was tested in vitro on a tapeworm Raillietina tetragona Molin (Davaineidae) to evaluate its potential anthelmintic efficacy and ultrastructural changes in the parasite. MATERIALS AND METHODS: Parasites were exposed to different concentrations of ethanolic leaf extract (10-80 mg/mL) and praziquantel (0.0005-0.005 mg/mL) and incubated in phosphate-buffered saline (PBS). The pH was 7.4 at 37 °C, while one set of worms was incubated only with PBS as a control. Permanent immobilization of worms was determined visually when no motility occurred on physically disturbing them. The parasites exposed to high concentrations of leaf extract and praziquantel treatments were processed for histological and electron microscopic studies, as these concentrations took the least time for paralysis and death to occur. RESULT: With an increase in the concentration of the leaf extract from 10 to 80 mg/mL and praziquantel from 0.0005 to 0.005 mg/mL, the time for the onset of paralysis and death was shortened. The treated parasites lost their spontaneous movement rapidly followed by death. Electron microscopic observations revealed disruptions in the tegument and parenchymal layer, accompanied by deformities in cell organelles. DISCUSSION AND CONCLUSION: Extensive structural alterations in the tegument indicate that the plant-derived components cause permeability changes in the parasite leading to paralysis and subsequent death. These observations suggest that phytochemicals present in C. viscosum have vermifugal or vermicidal activity, and thus may be exploited as alternative chemotherapeutic agents.
[Mh] Termos MeSH primário: Anticestoides/farmacologia
Cestoides/efeitos dos fármacos
Clerodendrum/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anticestoides/isolamento & purificação
Cestoides/crescimento & desenvolvimento
Cestoides/ultraestrutura
Relação Dose-Resposta a Droga
Etanol/química
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Testes de Sensibilidade Parasitária
Fitoterapia
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Plantas Medicinais
Praziquantel/farmacologia
Solventes/química
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticestodal Agents); 0 (Plant Extracts); 0 (Solvents); 3K9958V90M (Ethanol); 6490C9U457 (Praziquantel)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2016.1226367


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[PMID]:27830941
[Au] Autor:Mire S
[Ad] Endereço:a Faculty of Archaeology , Leiden University , Leiden , the Netherlands.
[Ti] Título:'The child that tiire doesn't give you, God won't give you either.' The role of Rotheca myricoides in Somali fertility practices.
[So] Source:Anthropol Med;23(3):311-331, 2016 Dec.
[Is] ISSN:1469-2910
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The paper introduces the Baanashada Dumarka, a Somali fertility therapy carried out by a spirit medium, known locally as 'Alaqad. Baanashada is aimed at women whose fertility issues are believed to be caused by spirits. The study also explores a component of the Baanashada, namely, the use of tiire (Rotheca myricoides), or the butterfly bush. Although Rotheca myricoides is known to possess a number of medicinal components as confirmed by studies of modern science, so far, there exist no studies on its potential (or lack of) fertility effects. Hence, the alleged fertility benefits of the butterfly bush need examining. In 2008 a British Somali woman died of herbs placed in her cervix by a traditional healer in Somaliland. This piece of information indicated not only the role of herbal medicine in fertility practices, but also the popularity of traditional reproductive medicine beyond border, class or educational background. Yet, current research into Somali women's health focuses mainly on Female Genital Mutilation (FGM), examined often without the context of wider cultural practices. This paper, however, suggests that rituals, beliefs and material culture play a paramount role in women's practices. For example, as explored elsewhere, the wagar, a wooden and sacred object made of the African olive, is critical for fertility practices. The current paper illuminates further the significance of reproduction practices in Somali society and the potential continuity of traditions associated with the perpetuation of kinship. It concludes that fertility rituals are part of a wider context of interaction with sacred landscapes, objects and archaeological sites, often associated with past legends in the Horn of Africa.
[Mh] Termos MeSH primário: Clerodendrum
Fármacos para a Fertilidade Feminina/administração & dosagem
Medicina Tradicional Africana/métodos
Fitoterapia/métodos
Plantas Medicinais
Saúde da Mulher/etnologia
[Mh] Termos MeSH secundário: Antropologia Médica
Clerodendrum/toxicidade
Cultura
Feminino
Fertilidade
Fármacos para a Fertilidade Feminina/toxicidade
Conhecimentos, Atitudes e Prática em Saúde/etnologia
Seres Humanos
Infertilidade Feminina/etnologia
Infertilidade Feminina/psicologia
Infertilidade Feminina/terapia
Entrevistas como Assunto
Medicina Tradicional Africana/efeitos adversos
Medicina Tradicional Africana/psicologia
Fitoterapia/efeitos adversos
Fitoterapia/psicologia
Plantas Medicinais/toxicidade
Somália
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertility Agents, Female)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE


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[PMID]:27825487
[Au] Autor:Passari AK; Mishra VK; Leo VV; Gupta VK; Singh BP
[Ad] Endereço:Molecular Microbiology and Systematics Laboratory, Department of Biotechnology, Aizawl, Mizoram University, Mizoram 796004 India.
[Ti] Título:Phytohormone production endowed with antagonistic potential and plant growth promoting abilities of culturable endophytic bacteria isolated from Clerodendrum colebrookianum Walp.
[So] Source:Microbiol Res;193:57-73, 2016 Dec.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this study, culturable endophytic bacterial isolates obtained from an ethnomedicinal plant Clerodendrum colebrookianum Walp., were assessed for their diversity, in vitro screening for their plant growth promoting (PGP) activities and to use them as inoculant for in vivo PGP activities with biocontrol potential. Totally, 73 isolates were recovered from different tissues of C. colebrookianum were identified by 16S rRNA gene sequencing and phylogenetically analyzed by using BOX-PCR fingerprinting. Out of 73 isolates, 52 exhibited varying extents of antagonistic potential were selected for screening for various PGP traits. Concerning the PGP activities, the percentage of isolates positive for P-solubilisation, indolic compounds production, siderophore and ammonia production were 84.6, 92.3, 78.8 and 98.0 respectively. All isolates were positive for the production of hydrocyanic acid (HCN) and 86.5%, 84.6% and 90.3% of isolates showed significant cellulase, amylase and protease production respectively. Further, the top 10 bacterial isolates based on a bonitur scale with multiple PGP activities were screened for root surface colonization and biofilm formation ability. Out of selected 10 isolates, 9 showed significant potential for root surface colonization on tomato roots. Isolate BPSAC6 identified as Bacillus sp. was most efficient in biofilm formation as assessed with respect to the intensity of crystal violet, which further showed their potential to withstand various biotic and abiotic stresses. Furthermore, Bacillus sp. strain BPSAC6 showed a significant increase in shoot and root height as well as fresh weight after 45 and 60 d of inoculation with tomato seedlings. Additionally, biosynthetic potential of antagonistic isolate was detection by using PKSI, PKSII and NRPS biosynthetic genes. Two isolates Pseudomonas psychrotolerans and Labrys wisconsinensis were reported first time as an endophyte. At last, first time an endophytic bacterial strain Bacillus sp. BPSAC6 was reported to produce altogether three phytohormones (IAA, Kinetin and 6-Benzyladenine). This study is the first report that bacteria isolated from C. colebrookianum has biocontrol as well as PGP abilities endowed with phytohormones production and can be used for the preparation of bioinoculant for plant growth promotion.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Bactérias/metabolismo
Clerodendrum/microbiologia
Endófitos/isolamento & purificação
Endófitos/metabolismo
Lycopersicon esculentum/crescimento & desenvolvimento
Reguladores de Crescimento de Planta/metabolismo
[Mh] Termos MeSH secundário: Bactérias/classificação
Bactérias/genética
Biofilmes/crescimento & desenvolvimento
Biomassa
Análise por Conglomerados
Impressões Digitais de DNA
DNA Ribossômico/química
DNA Ribossômico/genética
Endófitos/classificação
Endófitos/genética
Lycopersicon esculentum/microbiologia
Filogenia
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/microbiologia
Brotos de Planta/crescimento & desenvolvimento
Brotos de Planta/microbiologia
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal); 0 (Plant Growth Regulators); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27642406
[Au] Autor:Idoh K; Agbonon A; Potchoo Y; Gbeassor M
[Ad] Endereço:Laboratory of Physiology, Pharmacology and Toxicology, Faculty of Sciences, University of Lomé, Lomé, Togo.
[Ti] Título:Toxicological assessment of the hydroethanolic leaf extract of clerodendrum capitatum in Wistar rats.
[So] Source:Pan Afr Med J;24:66, 2016.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Clerodendrum capitatum (Willd) Schumach. & Thonn (Lamiaceae) is used in African traditional medicine for the treatment of malaria, hypertension, obesity, jaundice and diabetes however there is lack of experimental data on its possible toxicity. This study investigated the acute and 28 days sub-chronic toxicity of C. capitatum in Wistar rats. METHODS: In acute toxicity tests, a single administration of the hydroethanolic C. capitatum leaf extract (5 g/kg) was given orally to 5 female rats. The general behavior, adverse effects and mortality were recorded for up to 14 days post treatment. On the 15(th) day, the rats were weighed and euthanized for necropsy. In sub-chronic toxicity tests, the extract (4, 8 and 16 g/kg/day) was given orally to both male and female rats for 28 days. The animal body weight was recorded throughout the experiment, while hematological and biochemical parameters of blood and relative organs weights were evaluated on the 29(th) day. RESULTS: Clerodendrum Capitatum did not cause any death or any hazardous symptoms of acute toxicity, showing an LD50 higher than 5 g/kg. Sub-chronic administration of C. capitatum resulted in no noticeable changes in weight gain and water or food consumption. White blood cells and hemoglobin increased while urea concentration, liver enzymes, total cholesterol and glucose concentrations significantly decreased in treated animals. No changes in macroscopical aspect of organs were observed in the animals. CONCLUSION: These results showed that acute or sub-chronic oral administration of the hydroethanolic leaf extract of Clerodendrum capitatum may be considered as relatively free of toxicity.
[Mh] Termos MeSH primário: Clerodendrum/química
Extratos Vegetais/toxicidade
Testes de Toxicidade Aguda/métodos
Testes de Toxicidade Subcrônica/métodos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Feminino
Dose Letal Mediana
Masculino
Medicina Tradicional Africana
Tamanho do Órgão/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Folhas de Planta
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160920
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2016.24.66.8771


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[PMID]:27610825
[Au] Autor:Erukainure OL; Mesaik AM; Muhammad A; Chukwuma CI; Manhas N; Singh P; Aremu OS; Islam MS
[Ad] Endereço:Nutrition and Toxicology Division, Federal Institute of Industrial Research, Lagos, Nigeria; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan; Department of Biochemistry, School of Life S
[Ti] Título:Flowers of Clerodendrum volubile exacerbate immunomodulation by suppressing phagocytic oxidative burst and modulation of COX-2 activity.
[So] Source:Biomed Pharmacother;83:1478-1484, 2016 Oct.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The immunomodulatory potentials of the crude methanolic extract and fractions [n-hexane (Hex), n-dichloromethane (DCM), ethyl acetate (EtOAc) and n-butanol (BuOH)] of Clerodendrum volubile flowers were investigated on whole blood phagocytic oxidative burst using luminol-amplified chemiluminescence technique. They were also investigated for their free radicals scavenging activities. The DCM fraction showed significant (p<0.05) anti-oxidative burst and free radical scavenging activities indicating high immunomodulatory and antioxidant potencies respectively. Cytotoxicity assay of the DCM fraction revealed a cytotoxic effect on CC-1 normal cell line. GCMS analysis revealed the presence of triacetin; 3,6-dimethyl-3-octanol; 2R - Acetoxymethyl-1,3,3-trimethtyl - 4t - (3-methyl-2-buten-1-yl) - 1c - cyclohexanol and Stigmastan - 3,5-diene in DCM fraction. These compounds were docked with the active sites of cyclooxygenase-2 (COX-2). Triacetin, 3,6-dimethyl-3-Octanol, and 2R-Acetoxymethyl-1,3,3-trimethtyl-4t-(3-methyl-2-buten-1-yl)-1c-cyclohexanol docked comfortably with COX-2 with good scoring function (-CDocker energy) indicating their inhibitory potency against COX-2. 3,6-dimethyl-3-Octanol, displayed the lowest predicted free energy of binding (-21.4kcalmol ) suggesting its stronger interaction with COX-2, this was followed by 2R - Acetoxymethyl-1, 3, 3-trimethtyl-4t-(3-methyl-2-buten-1-yl)-1c-cyclhexanol (BE=-20.5kcalmol ), and triacetin (BE=-10.9kcalmol ). Stigmastan - 3,5-diene failed to dock with COX-2. The observed suppressive effect of the DCM fraction of C. volubile flower methanolic extract on phagocytic oxidative burst indicates an immunomodulatory potential. This is further reflected in its free scavenging activities and synergetic modulation of COX-2 activities by its identified compounds in silico.
[Mh] Termos MeSH primário: Clerodendrum
Ciclo-Oxigenase 2/metabolismo
Flores
Fagocitose/fisiologia
Extratos Vegetais/farmacologia
Explosão Respiratória/fisiologia
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Ciclo-Oxigenase 2/química
Relação Dose-Resposta a Droga
Ativação Enzimática/efeitos dos fármacos
Ativação Enzimática/fisiologia
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Imunomodulação/efeitos dos fármacos
Imunomodulação/fisiologia
Simulação de Acoplamento Molecular/métodos
Fagocitose/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Estrutura Secundária de Proteína
Explosão Respiratória/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Free Radical Scavengers); 0 (Plant Extracts); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE


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[PMID]:27226098
[Au] Autor:Dutta S; Guha P; Dey P; Chaudhuri TK
[Ti] Título:Comparative phytochemical profiling of Clerodendrum infortunatum with some selected medicinal plants predominant in the Sub-Himalayan region of West Bengal.
[So] Source:J Basic Clin Physiol Pharmacol;27(5):547-55, 2016 Sep 01.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of the present study was to quantify the phytochemicals of Clerodendrum infortunatum root and correlate on the basis of phytochemicals present with other medicinal plants belonging to different families. METHODS: Various standard biochemical and spectrophotometric methods were employed to study the phytochemical status of the root of C. infortunatum. All the analysis was performed in multiple sets. Various statistical methods like principal component analysis, dendogram, Euclidean distance and correlation study were done to compare the phytochemical profile of C. infortunatum with different selected medicinal plants belonging to different families. RESULTS: Results indicated the presence of various phytochemicals like phenol, alkaloid, flavonoid, tannin, thiamine, riboflavin, etc. Among the estimated phytochemicals, phenol had the highest quantity (65.59±1.26 mg/g) followed by lipid (27.51±0.23 mg/g) and tannin (16.40±0.07 mg/100 g). The phytochemical contents of C. infortunatum are much higher than those of the other reference plants. CONCLUSIONS: It may be concluded from the present study that the root of C. infortunatum contains very high amount of phytochemicals which are chiefly responsible for various medicinal properties. Therefore, the presence of the bioactive compounds in high quantity may lead to the potent medicinal value of C. infortunatum root.
[Mh] Termos MeSH primário: Clerodendrum/química
Compostos Fitoquímicos/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Lipídeos/química
Fenóis/química
Extratos Vegetais/química
Raízes de Plantas/química
Taninos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipids); 0 (Phenols); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Tannins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160527
[St] Status:MEDLINE



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