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Pesquisa : B01.650.940.800.575.912.250.583.520.166 [Categoria DeCS]
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[PMID]:26838869
[Au] Autor:Vilas V; Philip D; Mathew J
[Ad] Endereço:Department of Physics, Mar Ivanios College, Thiruvananthapuram 695015, India; Department of Chemistry, Mar Ivanios College, Thiruvananthapuram 695015, India.
[Ti] Título:Essential oil mediated synthesis of silver nanocrystals for environmental, anti-microbial and antioxidant applications.
[So] Source:Mater Sci Eng C Mater Biol Appl;61:429-36, 2016 Apr 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Our quest for a green, non-toxic and environmentally benign synthetic design for the fabrication of metal nanoparticles has led to the use of essential oil present in plant parts as the bioreductant. In this report, silver particles at nanoscale have been synthesized using essential oil present in the leaves of Coleus aromaticus at physiological pH and at 373 K. UV-vis spectra of the colloid display strong plasmon bands centred around 396-411 nm, characteristic of silver nanoparticles. Comparative studies of the FTIR spectra of essential oil and silver nanoparticles reveal the involvement of terpenes and their phenolic derivatives in reduction and subsequent stabilization. TEM micrographs and XRD pattern show the formation of 26 and 28 nm sized face centred cubic structured crystalline nanospheroids with intermittent formation of nanorods. The phytosynthesized silver nanoparticles are found to be effective in degrading hazardous organic pollutants including methyl orange, methylene blue, eosin yellowish and para nitro phenol within a span of a few minutes. Dose dependant antibacterial activity of the biogenic nanosilver against pathogenic Gramme-negative Escherichia coli (ATCC 25922) and Gramme-positive Staphylococcus aureus (ATCC 25923) has been portrayed through agar-well dispersion method. The antioxidant activity including antiradical activity and reducing power have been depicted through superoxide radical scavenging activity, hydroxyl radical scavenging activity, hydrogen peroxide scavenging activity, nitric oxide scavenging activity, DPPH assay and reducing power activity involving the reduction of ferric ion.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Antioxidantes/síntese química
Nanopartículas Metálicas/química
Óleos Voláteis/química
Prata/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Antioxidantes/química
Compostos Azo/química
Catálise
Coleus/química
Coleus/metabolismo
Amarelo de Eosina-(YS)/química
Escherichia coli/efeitos dos fármacos
Química Verde
Nanopartículas Metálicas/toxicidade
Nanopartículas Metálicas/ultraestrutura
Azul de Metileno/química
Testes de Sensibilidade Microbiana
Nitrofenóis/química
Folhas de Planta/química
Folhas de Planta/metabolismo
Espectroscopia de Infravermelho com Transformada de Fourier
Staphylococcus aureus/efeitos dos fármacos
Superóxidos/química
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Azo Compounds); 0 (Nitrophenols); 0 (Oils, Volatile); 0 (Water Pollutants, Chemical); 11062-77-4 (Superoxides); 3M4G523W1G (Silver); 6B4TC34456 (methyl orange); T42P99266K (Methylene Blue); TDQ283MPCW (Eosine Yellowish-(YS)); Y92ZL45L4R (4-nitrophenol)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170103
[Lr] Data última revisão:
170103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160204
[St] Status:MEDLINE


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[PMID]:26690294
[Au] Autor:Chopra N; Hays L
[Ad] Endereço:Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY.
[Ti] Título:Are We Growing Psychotropics in Our Backyards?: A Case Report and Literature Review of Coleus blumei.
[So] Source:J Addict Med;10(1):68-9, 2016 Jan-Feb.
[Is] ISSN:1935-3227
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There have been very limited reports of the euphoria experienced under the influence of Coleus blumei--part of a large genus with similarities to various mints and herbs, naturally found in abundance and popular in home gardens. There have been reports of similar properties to Salvia divinorum, which contains the psychoactive neocleordane diterpene salvinorin-A. We present a case of a man in his twenties, with no significant known personal or family psychiatric history, presenting to an emergency room with a psychotic episode after the ingestion of C. blumei. He had chewed leaves of this plant, with the intention of obtaining a euphoric experience, as learned through social media posts. Comprehensive laboratory work-up drug screening and diagnostic imaging were negative. Vital signs were stable and physical examination was unremarkable. His mental status improved significantly after treatment with risperidone 2 mg twice daily, during a 5-day psychiatric hospitalization. This case draws attention to a potential psychotropic that warrants clinical consideration and further investigation.
[Mh] Termos MeSH primário: Coleus/efeitos adversos
Folhas de Planta/efeitos adversos
Psicoses Induzidas por Substâncias/etiologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Psicoses Induzidas por Substâncias/tratamento farmacológico
Psicotrópicos/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Psychotropic Drugs)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE
[do] DOI:10.1097/ADM.0000000000000189


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[PMID]:26448466
[Au] Autor:Zhu Q; Sui S; Lei X; Yang Z; Lu K; Liu G; Liu YG; Li M
[Ad] Endereço:State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.
[Ti] Título:Ectopic Expression of the Coleus R2R3 MYB-Type Proanthocyanidin Regulator Gene SsMYB3 Alters the Flower Color in Transgenic Tobacco.
[So] Source:PLoS One;10(10):e0139392, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Proanthocyanidins (PAs) play an important role in plant disease defense and have beneficial effects on human health. We isolated and characterized a novel R2R3 MYB-type PA-regulator SsMYB3 from a well-known ornamental plant, coleus (Solenostemon scutellarioides), to study the molecular regulation of PAs and to engineer PAs biosynthesis. The expression level of SsMYB3 was correlated with condensed tannins contents in various coleus tissues and was induced by wounding and light. A complementation test in the Arabidopsis tt2 mutant showed that SsMYB3 could restore the PA-deficient seed coat phenotype and activated expression of the PA-specific gene ANR and two related genes, DFR and ANS. In yeast two-hybrid assays, SsMYB3 interacted with the Arabidopsis AtTT8 and AtTTG1 to reform the ternary transcriptional complex, and also interacted with two tobacco bHLH proteins (NtAn1a and NtJAF13-1) and a WD40 protein, NtAn11-1. Ectopic overexpression of SsMYB3 in transgenic tobacco led to almost-white flowers by greatly reducing anthocyanin levels and enhancing accumulation of condensed tannins. This overexpression of SsMYB3 upregulated the key PA genes (NtLAR and NtANR) and late anthocyanin structural genes (NtDFR and NtANS), but downregulated the expression of the final anthocyanin gene NtUFGT. The formative SsMYB3-complex represses anthocyanin accumulation by directly suppressing the expression of the final anthocyanin structural gene NtUFGT, through competitive inhibition or destabilization of the endogenous NtAn2-complex formation. These results suggested that SsMYB3 may form a transcription activation complex to regulate PA biosynthesis in the Arabidopsis tt2 mutant and transgenic tobacco. Our findings suggest that SsMYB3 is involved in the regulation of PA biosynthesis in coleus and has the potential as a molecular tool for manipulating biosynthesis of PAs in fruits and other crops using metabolic engineering.
[Mh] Termos MeSH primário: Coleus/genética
Expressão Ectópica do Gene
Pigmentação/genética
Proteínas de Plantas/genética
Proantocianidinas/metabolismo
Tabaco/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Arabidopsis/genética
Arabidopsis/metabolismo
Proteínas de Arabidopsis/genética
Proteínas de Arabidopsis/metabolismo
Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética
Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo
Clonagem Molecular
Flores/genética
Dados de Sequência Molecular
Filogenia
Folhas de Planta/genética
Proteínas de Plantas/classificação
Proteínas de Plantas/metabolismo
Plantas Geneticamente Modificadas/genética
Proantocianidinas/análise
Alinhamento de Sequência
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (Basic Helix-Loop-Helix Transcription Factors); 0 (Plant Proteins); 0 (Proanthocyanidins); 18206-61-6 (proanthocyanidin)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151009
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0139392


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[PMID]:26389875
[Au] Autor:Zhu Q; Xie X; Lin H; Sui S; Shen R; Yang Z; Lu K; Li M; Liu YG
[Ad] Endereço:State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China. zhuql@scau.edu.cn.
[Ti] Título:Isolation and Functional Characterization of a Phenylalanine Ammonia-Lyase Gene (SsPAL1) from Coleus (Solenostemon scutellarioides (L.) Codd).
[So] Source:Molecules;20(9):16833-51, 2015 Sep 16.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Phenylalanine ammonia-lyase (PAL) is the first enzyme involved in the phenylpropanoid pathway and plays important roles in the secondary metabolisms, development and defense of plants. To study the molecular function of PAL in anthocyanin synthesis of Coleus (Solenostemon scutellarioides (L.) Codd), a Coleus PAL gene designated as SsPAL1 was cloned and characterized using a degenerate oligonucleotide primer PCR and RACE method. The full-length SsPAL1 was 2450 bp in size and consisted of one intron and two exons encoding a polypeptide of 711 amino acids. The deduced SsPAL1 protein showed high identities and structural similarities with other functional plant PAL proteins. A series of putative cis-acting elements involved in transcriptional regulation, light and stress responsiveness were found in the upstream regulatory sequence of SsPAL1. Transcription pattern analysis indicated that SsPAL1 was constitutively expressed in all tissues examined and was enhanced by light and different abiotic factors. The recombinant SsPAL1 protein exhibited high PAL activity, at optimal conditions of 60 °C and pH 8.2. Although the levels of total PAL activity and total anthocyanin concentration have a similar variation trend in different Coleus cultivars, there was no significant correlation between them (r = 0.7529, p > 0.1), suggesting that PAL was not the rate-limiting enzyme for the downstream anthocyanin biosynthetic branch in Coleus. This study enables us to further understand the role of SsPAL1 in the phenylpropanoid (flavonoids, anthocyanins) biosynthesis in Coleus at the molecular level.
[Mh] Termos MeSH primário: Coleus/enzimologia
Fenilalanina Amônia-Liase/isolamento & purificação
Fenilalanina Amônia-Liase/metabolismo
Proteínas de Plantas/metabolismo
Proteínas Recombinantes/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Sequência de Bases
Clonagem Molecular
Perfilação da Expressão Gênica
Regulação da Expressão Gênica de Plantas
Modelos Moleculares
Dados de Sequência Molecular
Fenilalanina Amônia-Liase/química
Fenilalanina Amônia-Liase/genética
Filogenia
Proteínas de Plantas/química
Proteínas de Plantas/genética
Proteínas de Plantas/isolamento & purificação
Reação em Cadeia da Polimerase
Conformação Proteica
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/isolamento & purificação
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Recombinant Proteins); EC 4.3.1.24 (Phenylalanine Ammonia-Lyase)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150922
[St] Status:MEDLINE
[do] DOI:10.3390/molecules200916833


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[PMID]:25862643
[Au] Autor:Logan BA; Stafstrom WC; Walsh MJ; Reblin JS; Gould KS
[Ad] Endereço:Biology Department, Bowdoin College, Brunswick, ME, 04011, USA, blogan@bowdoin.edu.
[Ti] Título:Examining the photoprotection hypothesis for adaxial foliar anthocyanin accumulation by revisiting comparisons of green- and red-leafed varieties of coleus (Solenostemon scutellarioides).
[So] Source:Photosynth Res;124(3):267-74, 2015 Jun.
[Is] ISSN:1573-5079
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Although plants rely on light to drive energy production via photosynthesis, excess light can be harmful. Plants have evolved photoprotective mechanisms to mitigate this threat, including thermal energy dissipation, the most common form of which involves de-epoxidized constituents of the xanthophyll cycle facilitating the conversion of excess excitation energy to heat. A role in photoprotection has also been proposed for red anthocyanins when they accumulate near the adaxial leaf surface. Here, we compared the response to experimental light stress of a red-leafed (anthocyanin rich) and a green-leafed variety of coleus [Solenostemon scutellarioides (L.) Codd], examining chlorophyll fluorescence emission and pigment composition. After experimentally imposed intense white light, red- and green-leafed coleus exhibited manifestations of light stress (decreased photosystem II quantum efficiency) of a similar magnitude. This, considered alone, could be interpreted as evidence that anthocyanins do not serve a photoprotective role. However, during excess light exposure, the green-leafed variety employed a greater level of thermal energy dissipation and possessed correspondingly higher xanthophyll cycle pool sizes and de-epoxidation states. During exposure to red light, which anthocyanins absorb very poorly, levels of thermal energy dissipation did not differ between coleus varieties. Taken together, our findings suggest that adaxial anthocyanins minimize stress associated with excess light absorption and that the green-leafed variety of coleus compensated for its much lower levels of adaxial anthocyanins by invoking higher levels of energy dissipation. Thus, anthocyanin accumulation should be considered alongside the suite of photoprotective mechanisms employed by photosynthetic tissues.
[Mh] Termos MeSH primário: Antocianinas/fisiologia
Coleus/efeitos da radiação
Luz
Estresse Fisiológico
[Mh] Termos MeSH secundário: Antocianinas/metabolismo
Coleus/metabolismo
Complexo de Proteína do Fotossistema II/metabolismo
Complexo de Proteína do Fotossistema II/fisiologia
Folhas de Planta/metabolismo
Folhas de Planta/efeitos da radiação
Xantofilas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Photosystem II Protein Complex); 0 (Xanthophylls)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150412
[St] Status:MEDLINE
[do] DOI:10.1007/s11120-015-0130-0


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[PMID]:25726172
[Au] Autor:Mohammed KP; Aarey A; Tamkeen S; Jahan P
[Ad] Endereço:Department of Genetics, Osmania University, Hyderabad, Andhra Pradesh, India.
[Ti] Título:Forskolin: genotoxicity assessment in Allium cepa.
[So] Source:Mutat Res Genet Toxicol Environ Mutagen;777:29-32, 2015 Jan 01.
[Is] ISSN:1879-3592
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Forskolin, a diterpene, 7ß-acetoxy-8,13-epoxy-1α,6ß,9α-trihydroxy-labd-14-en-11-one (C22H34O7) isolated from Coleus forskohlii, exerts multiple physiological effects by stimulating the enzyme adenylate cyclase and increasing cyclic adenosine monophosphate (cAMP) concentrations. Forskolin is used in the treatment of hypertension, congestive heart failure, eczema, and other diseases. A cytogenetic assay was performed in Allium cepa to assess possible genotoxic effects of forskolin. Forskolin was tested at concentrations 5-100 µM for exposure periods of 24 or 48 h. Treated samples showed significant reductions in mitotic index (p < 0.05) and increases in the frequency of chromosome aberrations (p < 0.01) at both exposure times. The treated meristems showed chromosome aberrations including sticky metaphases, sticky anaphases, laggard, anaphase bridges, micronuclei, polyploidy, fragments, breaks, and C-mitosis. Forskolin may cause genotoxic effects and further toxicological evaluations should be conducted to ensure its safety.
[Mh] Termos MeSH primário: Broncodilatadores/toxicidade
Aberrações Cromossômicas
Colforsina/toxicidade
Meristema/efeitos dos fármacos
Cebolas/efeitos dos fármacos
Vasodilatadores/toxicidade
[Mh] Termos MeSH secundário: Anáfase/efeitos dos fármacos
Broncodilatadores/isolamento & purificação
Coleus/química
Colforsina/isolamento & purificação
Seres Humanos
Meristema/citologia
Meristema/genética
Metáfase/efeitos dos fármacos
Micronúcleos com Defeito Cromossômico
Testes de Mutagenicidade
Cebolas/citologia
Cebolas/genética
Poliploidia
Vasodilatadores/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Vasodilator Agents); 1F7A44V6OU (Colforsin)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:150302
[Lr] Data última revisão:
150302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150302
[St] Status:MEDLINE


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[PMID]:25567191
[Au] Autor:Hu MH; Yuan JH
[Ad] Endereço:Institute of Poyang Lake Eco-economics, Jiangxi University of Finance and Economics, Nanchang, 330032, Jiangxi, China, yankeu@gmail.com.
[Ti] Título:Changes in the spectral pattern of selenium accumulation in Coleus blumei and the effects of chelation.
[So] Source:Ecotoxicology;24(3):686-99, 2015 Apr.
[Is] ISSN:1573-3017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chemically enhanced phytoremediation has been proposed as an effective approach to remove heavy metals from contaminated soil through the use of high biomass production plants. This study investigated changes in the spectral pattern of selenium (Se) accumulation in Coleus blumei Benth. (coleus) plants grown in hydroponics with 1.0 mg/l sodium selenite (Na2SeO3) and the effects of (S,S)-ethylenediamine disuccinic acid (EDDS) thereon through X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDXS) and Fourier transform infrared (FTIR) spectroscopy analyses. When EDDS concentrations were in the range of 0-1.0 mmol/l, Se content increased significantly; however, at EDDS concentrations above this range, the symptoms of Se toxicity were alleviated in coleus leaves. Application of EDDS over 1.0 mmol/l significantly decreased total Se uptake in the leaves and roots of the plants. The powder diffraction patterns of the roots and leaves displayed sharp crystalline peaks, which were characteristic of an organic molecule with crystallinity. Our results revealed the presence of high amounts of C, O, Mg, Al, Si, K and Ca in the roots and leaves under Se-induced stress with different concentrations of EDDS. There were no changes in the chemical compositions of the roots and leaves, but the contents were influenced by Se-induced stress and EDDS treatment. This study demonstrated the importance of applying XRD, EDXS and FTIR methods toward a more comprehensive understanding of the mechanisms of EDDS-induced Se accumulation in plants.
[Mh] Termos MeSH primário: Quelantes/farmacologia
Coleus/efeitos dos fármacos
Coleus/metabolismo
Etilenodiaminas/farmacologia
Selenito de Sódio/metabolismo
Poluentes do Solo/metabolismo
Succinatos/farmacologia
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Hidroponia
Folhas de Planta/efeitos dos fármacos
Raízes de Plantas/efeitos dos fármacos
Espectrometria por Raios X
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Ethylenediamines); 0 (Soil Pollutants); 0 (Succinates); 20846-91-7 (N,N'-ethylenediamine disuccinic acid); HIW548RQ3W (Sodium Selenite)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150109
[St] Status:MEDLINE
[do] DOI:10.1007/s10646-014-1415-3


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[PMID]:24990552
[Au] Autor:Yokotani K; Chiba T; Sato Y; Umegaki K
[Ad] Endereço:Information Center, National Institute of Health and Nutrition.
[Ti] Título:Coleus forskohlii extract attenuates the hypoglycemic effect of tolbutamide in vivo via a hepatic cytochrome P450-mediated mechanism.
[So] Source:Shokuhin Eiseigaku Zasshi;55(2):73-8, 2014.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This in vivo study in rats evaluated whether Coleus forskohlii extract (CFE) taken orally interacted with tolbutamide, a hypoglycemic drug metabolized by CYP2C enzymes. Rats were fed 0%, 0.3%, 1% (w/w) CFE diet for 2 weeks, followed by 0% CFE diet for 1 day. They were then given 40 mg/kg tolbutamide by intragastric gavage. Blood glucose level was determined up to 6 h after tolbutamide administration. CFE treatment increased total CYP content and various CYP subtypes in the liver. In particular, increases in activity and protein expression were noted for the CYP2B, CYP2C, and CYP3A subtypes. CFE treatment dose-dependently attenuated both the hypoglycemic action of tolbutamide at 6 h and the plasma concentration of tolbutamide. The activity of (S)-warfarin 7-hydroxylase, a CYP2C enzyme was negatively correlated with plasma tolbutamide level, which also showed a negative correlation with the reduction of blood glucose level. These results indicate that CFE induced hepatic CYPs in rats and attenuated the hypoglycemic action of tolbutamide via a hepatic CYP2C-mediated mechanism.
[Mh] Termos MeSH primário: Coleus
Sistema Enzimático do Citocromo P-450/metabolismo
Interações Ervas-Drogas
Hipoglicemiantes/farmacologia
Fígado/enzimologia
Extratos Vegetais/efeitos adversos
Extratos Vegetais/farmacologia
Tolbutamida/farmacologia
[Mh] Termos MeSH secundário: Animais
Masculino
Vacina contra Caxumba
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Mumps Vaccine); 0 (Plant Extracts); 0 (cytochrome P-450 CYP2C subfamily); 9035-51-2 (Cytochrome P-450 Enzyme System); 982XCM1FOI (Tolbutamide)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:140703
[Lr] Data última revisão:
140703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140704
[St] Status:MEDLINE


  9 / 90 MEDLINE  
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[PMID]:24800669
[Au] Autor:Wadikar DD; Premavalli KS
[Ad] Endereço:Defence Food Research Laboratory, Siddarthanagar, India. Electronic address: Ddwadikar@gmail.com.
[Ti] Título:Beverage from Coleus aromaticus reduces leptin levels and improves appetite rating in human volunteers.
[So] Source:Nutrition;30(6):702-5, 2014 Jun.
[Is] ISSN:1873-1244
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Coleus aromaticus, commonly called country borage or Indian borage, is a perennial herb grown throughout the Indian subcontinent. Traditionally, the leaves of the plant are used as a cure for cold, cough, and fever as well as to relieve pain from skin irritations. However, the appetite-enhancing potential of the herb was unexplored. Based on the encouraging results of animal studies, this study was taken up to establish the appetite-enhancing potential of Coleus aromaticus in humans by evaluating its ready-to-drink beverage. METHODS: A homogenous and healthy group of volunteers was selected. Ready-to-drink beverages based on the herb karpurvalli (Coleus aromaticus) containing three different concentrations (12% [sensorily optimized level], 18%, and 24%) of the herb juice and a placebo beverage were evaluated with the volunteers. The fasting and postprandial levels of plasma leptin were measured, and the appetite rating on a structured visual analog scale was obtained. RESULTS: The study revealed a significant reduction in leptin levels with 12% juice, whereas a significant increase was seen after consumption of the beverage containing 24%. A similar pattern was obtained with the structured ratings. CONCLUSION: The appetite-enhancing effect of the beverage was best when it contained the sensorily optimized level of karpurvalli juice and confirms the results obtained in animal study. To our knowledge, this is the first study validating the appetite-enhancing potential of the herb.
[Mh] Termos MeSH primário: Apetite/efeitos dos fármacos
Bebidas/análise
Coleus/química
Leptina/sangue
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Adulto
Estatura
Índice de Massa Corporal
Peso Corporal
Jejum
Feminino
Seres Humanos
Masculino
Músculo Esquelético/metabolismo
Extratos Vegetais/farmacologia
Folhas de Planta/química
Período Pós-Prandial
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Leptin); 0 (Plant Extracts)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140507
[Lr] Data última revisão:
140507
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140508
[St] Status:MEDLINE


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[PMID]:24681320
[Au] Autor:Naraginti S; Sivakumar A
[Ad] Endereço:Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, India.
[Ti] Título:Eco-friendly synthesis of silver and gold nanoparticles with enhanced bactericidal activity and study of silver catalyzed reduction of 4-nitrophenol.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;128:357-62, 2014 Jul 15.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study reports a simple and robust method for synthesis of silver and gold nanoparticles using Coleus forskohlii root extract as reducing and stabilizing agent. Stable silver nanoparticles (AgNPs) and gold nanopoarticles (AuNPs) were formed on treatment of an aqueous silver nitrate (AgNO3) and chloroauric acid (HAuCl4) solutions with the root extract. The nanoparticles obtained were characterized by UV-Visible spectroscopy, Transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR). UV-Vis and TEM analysis indicate that with higher quantities of root extract, the interaction is enhanced leading to size reduction of spherical metal nanoparticles. XRD confirms face-centered cubic phase and the diffraction peaks can be attributed to (111), (200), (222) and (311) planes for these nanoparticles. These synthesized Ag and Au nanoparticles were found to exhibit excellent bactericidal activity against clinically isolated selected pathogens such as Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). The synthesized AgNPs were also found to function as an efficient green catalyst in the reduction of anthropogenic pollutant 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) by sodium borohydride, which was apparent from the periodical color change from bright yellow to colorless, after the addition of AgNPs.
[Mh] Termos MeSH primário: Antibacterianos
Bactérias/crescimento & desenvolvimento
Coleus/química
Ouro/química
Nanopartículas Metálicas/química
Nitrobenzenos/química
Raízes de Plantas/química
Prata/química
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Antibacterianos/farmacologia
Catálise
Nanopartículas Metálicas/ultraestrutura
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Nitrobenzenes); 3M4G523W1G (Silver); 7440-57-5 (Gold); O0A69I1MCU (4-nitrophenetol)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140401
[St] Status:MEDLINE



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