Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.520.231 [Categoria DeCS]
Referências encontradas : 9 [refinar]
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  1 / 9 MEDLINE  
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[PMID]:27131433
[Au] Autor:Leyva-López N; Nair V; Bang WY; Cisneros-Zevallos L; Heredia JB
[Ad] Endereço:Centro de Investigación en Alimentación y Desarrollo A.C., Carretera a Eldorado km 5.5 Col. El Diez C.P. 80110, Culiacán, Sinaloa, México.
[Ti] Título:Protective role of terpenes and polyphenols from three species of Oregano (Lippia graveolens, Lippia palmeri and Hedeoma patens) on the suppression of lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells.
[So] Source:J Ethnopharmacol;187:302-12, 2016 Jul 01.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Mexican oregano infusions have been traditionally used in México for the treatment of inflammation-related diseases, such as respiratory and digestive disorders, headaches and rheumatism, among others. Nevertheless, there is limited information regarding the phenolic compounds, terpenes and composition as well as biological activity of Mexican oregano. AIM OF THE STUDY: To determine the phenolic and terpene composition and to evaluate the anti-inflammatory potential of three species of Mexican oregano (Lippia graveolens (LG), Lippia palmeri (LP) and Hedeoma patens (HP)) in order to provide a scientific basis for their use. MATERIALS AND METHODS: We obtained methanol and chloroform extracts from dried oregano leaves of each species. We used LC-DAD-ESI-MS/MS and GC-MS to determine the phenolic and terpene profiles of the leaves, respectively. We evaluated anti-inflammatory potential by measuring the effect of Mexican oregano extracts on some pro-inflammatory mediators, such as nitric oxide (NO) and reactive oxygen species (ROS) using lipopolysaccharide(LPS)-stimulated RAW 264.7 macrophage cells and evaluating cyclooxygenase activity (COX-1, COX-2). RESULTS: Nine phenolic compounds (phenolic acids and flavonoids) and 22 terpenes (monoterpenes and sesquiterpenes) were detected in LG, LP and HP. We studied extracts from LG, LP and HP, and fractions from LG and LP in order to know their effect on some pro-inflammatory mediators. The phenolic and terpene extracts from LG, LP and HP exhibited significant inhibitory effect on ROS and NO production and mitochondrial activity in LPS-induced inflammation in RAW 264.7 macrophage cells. Nitric oxide production was also diminished by the terpene LG fraction LGF2 and the LP fractions LPF1, LPF2 and LPF3, confirming that both monoterpenes and sesquiterpenes are active compounds of oregano. Furthermore, the total extracts of LG, LP and HP exhibited non-selective inhibitions against the activity of the cyclooxygenases COX-1 and COX-2. CONCLUSIONS: Our results suggest that Lippia graveolens, Lippia palmeri and Hedeoma patens extracts have the potential to treat inflammatory diseases; their activity is mediated by polyphenols and terpenes. These findings support the claim for their traditional use in the treatment of inflammation-related diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Hedeoma
Lippia
Polifenóis/farmacologia
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Inflamação/induzido quimicamente
Inflamação/tratamento farmacológico
Lipopolissacarídeos
Macrófagos/efeitos dos fármacos
Camundongos
Óxido Nítrico/metabolismo
Extratos Vegetais/química
Folhas de Planta
Polifenóis/análise
Células RAW 264.7
Espécies Reativas de Oxigênio/metabolismo
Terpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (Polyphenols); 0 (Reactive Oxygen Species); 0 (Terpenes); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160502
[St] Status:MEDLINE


  2 / 9 MEDLINE  
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[PMID]:22951395
[Au] Autor:Coelho JP; Cristino AF; Matos PG; Rauter AP; Nobre BP; Mendes RL; Barroso JG; Mainar A; Urieta JS; Fareleira JM; Sovová H; Palavra AF
[Ad] Endereço:Centro de Investigação de Engenharia Química e Biotecnologia, Instituto Superior de Engenharia de Lisboa, Rua Conselheiro Emídio Navarro, 1, Lisboa 1959-007, Portugal. jcoelho@deq.isel.ipl.pt
[Ti] Título:Extraction of volatile oil from aromatic plants with supercritical carbon dioxide: experiments and modeling.
[So] Source:Molecules;17(9):10550-73, 2012 Sep 05.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:An overview of the studies carried out in our laboratories on supercritical fluid extraction (SFE) of volatile oils from seven aromatic plants: pennyroyal (Mentha pulegium L.), fennel seeds (Foeniculum vulgare Mill.), coriander (Coriandrum sativum L.), savory (Satureja fruticosa Béguinot), winter savory (Satureja montana L.), cotton lavender (Santolina chamaecyparisus) and thyme (Thymus vulgaris), is presented. A flow apparatus with a 1 L extractor and two 0.27 L separators was built to perform studies at temperatures ranging from 298 to 353 K and pressures up to 30.0 MPa. The best compromise between yield and composition compared with hydrodistillation (HD) was achieved selecting the optimum experimental conditions of extraction and fractionation. The major differences between HD and SFE oils is the presence of a small percentage of cuticular waxes and the relative amount of thymoquinone, an oxygenated monoterpene with important biological properties, which is present in the oils from thyme and winter savory. On the other hand, the modeling of our data on supercritical extraction of volatile oil from pennyroyal is discussed using Sovová's models. These models have been applied successfully to the other volatile oil extractions. Furthermore, other experimental studies involving supercritical CO(2) carried out in our laboratories are also mentioned.
[Mh] Termos MeSH primário: Cromatografia com Fluido Supercrítico
Óleos Voláteis/química
Óleos Voláteis/isolamento & purificação
Óleos Vegetais/química
Óleos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: Dióxido de Carbono
Coriandrum/química
Foeniculum/química
Hedeoma/química
Lavandula/química
Extratos Vegetais/química
Satureja/química
Thymus (Planta)/química
Thymus (Planta)/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plant Oils); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120907
[St] Status:MEDLINE
[do] DOI:10.3390/molecules170910550


  3 / 9 MEDLINE  
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[PMID]:21870634
[Au] Autor:Viveros-Valdez E; Rivas-Morales C; Oranday-Cardenas A; Verde-Star MJ; Carranza-Rosales P
[Ad] Endereço:Department of Chemistry, Faculty of Biological Sciences, Autonomous University of Nuevo Leon, San Nicolas de los Garza, Mexico.
[Ti] Título:Antimicrobial activity of Hedeoma drummondii against opportunistic pathogens.
[So] Source:Pak J Biol Sci;14(4):305-7, 2011 Feb 15.
[Is] ISSN:1028-8880
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Hedeoma drummondii is a medicinal plant with diverse properties; however, validations of its medicinal uses are scarce. To evaluate its antimicrobial properties H. drummondii, was tested against opportunistic pathogens of medical importance. Antimicrobial tests were performed by the microdilution method in order to determine the Minimal Inhibitory Concentration (MIC) for each extract. Extracts of this plant showed relevant antimicrobial activity, results revealed that the hexanic extract has stronger activity and broader spectrum compared to acetone and methanol extracts. The activity of hexanic extract may be attributed mainly to the presence of the monoterpenes pulegone and menthol. In conclusion, the hexanic extract possess relevant antibacterial properties which suggests that H. drummondii have bioactive principles; these new data provide scientific support for the use of this plant in traditional medicine, particularly for gastrointestinal diseases.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Hedeoma/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Bactérias/efeitos dos fármacos
Hexanos/química
Testes de Sensibilidade Microbiana
Monoterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Hexanes); 0 (Monoterpenes); 0 (Plant Extracts); 4LF2673R3G (pulegone)
[Em] Mês de entrada:1109
[Cu] Atualização por classe:150311
[Lr] Data última revisão:
150311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110830
[St] Status:MEDLINE


  4 / 9 MEDLINE  
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[PMID]:21385095
[Au] Autor:Dadé MM; Schinella GR; Fioravanti DE; Alfiotournier H
[Ad] Endereço:Facultad de Ciencias Médicas, Cátedra de Farmacología Básica, Universidad Nacional de La Plata, La Plata, Argentina.
[Ti] Título:Antioxidant and cytotoxic properties of an aqueous extract from the Argentinean plant Hedeoma multiflorum.
[So] Source:Pharm Biol;49(6):633-9, 2011 Jun.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Hedeoma multiflorum Benth. (Lamiaceae) is widely used in Argentinean popular medicine for digestive and anti-spasmodic purposes. However, knowledge about its pharmacological properties has been poorly investigated. OBJECTIVE: The antioxidant and cytotoxic properties of an aqueous extract from the plant were investigated for the first time. MATERIAL AND METHODS: Scavenging of stable free radicals of 2,2-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS(+)) and 2,2-diphenyl-1-picryl hydrazyl (DPPH), reducing of ferric (III) iron of ferric reducing ability of plasma (FRAP) reagent, and inhibition of lipid peroxidation (LP) of human plasma and rat brain homogenates were assessed. Cytotoxicity was tested on human polymorphonuclear (PMN) cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Cytotoxicity was assessed by flow cytometric techniques. RESULTS: Extract scavenged ABTS(+) and DPPH (1.78 and 0.78 µmol Trolox equivalent/mg dry extract, respectively) and reduced FRAP reagent (0.66 µmol ascorbic acid equivalent/mg dry extract). LP of human plasma and rat brain was also inhibited in a dose-dependent way (inhibitory concentration 50%=27.0 and 86.0 µg/mL, respectively). Extract is rich in polyphenol compounds (0.96 ± 0.08 µmol equivalent caffeic acid/mg dry matter). Treatment of PMN decreased significantly the cell ability to reduce the MTT salt and increased the hypodiploid nuclei from 4 to 18% quantified using propidium iodide (PI). In the annexin V-Fluorescein isothiocyanate (annexin V-FITC) assay, 26% of treated cells were annexin V-FITC positive and PI negative. Using the 3,3'-dihexyloxacarbocyanine iodide uptake method, the negative fraction of cells was calculated as 29%. DISCUSSION AND CONCLUSION: H. multiflorum extract was found to have a significant antioxidant and pro-apoptotic activities, and a great potential as a source of healthy products.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Hedeoma/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Apoptose/efeitos dos fármacos
Argentina
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Células Cultivadas
Relação Dose-Resposta a Droga
Radicais Livres/metabolismo
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Neutrófilos/efeitos dos fármacos
Oxirredução/efeitos dos fármacos
Extratos Vegetais/química
Plasma/metabolismo
Ratos
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Free Radicals); 0 (Plant Extracts); 059QF0KO0R (Water)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110310
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2010.526949


  5 / 9 MEDLINE  
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[PMID]:20406139
[Au] Autor:Viveros-Valdez E; Rivas-Morales C; Oranday-Cárdenas A; Castro-Garza J; Carranza-Rosales P
[Ad] Endereço:Departamento de Química, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, México.
[Ti] Título:Antiproliferative effect from the Mexican poleo (Hedeoma drummondii).
[So] Source:J Med Food;13(3):740-2, 2010 Jun.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hedeoma drummondii (poleo) has been used by Mexicans to prepare a tea for its pleasant taste. The methanolic extract, polar fractions, and major antioxidant compounds of the Mexican herbal tea obtained from aerial parts of H. drummondii ("poleo") showed antiproliferative effects against the cancer cell lines MCF-7 (human breast) and HeLa (human cervix). Phenolic acids isolated from poleo have significant antiproliferative effects with caffeic acid the most potent. This evidence suggests that herbal poleo tea may have chemopreventive properties.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Hedeoma/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/análise
Antioxidantes/farmacologia
Ácidos Cafeicos/análise
Ácidos Cafeicos/farmacologia
Linhagem Celular Tumoral
Células HeLa
Seres Humanos
México
Extratos Vegetais/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Caffeic Acids); 0 (Plant Extracts); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:121115
[Lr] Data última revisão:
121115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100422
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2009.0041


  6 / 9 MEDLINE  
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[PMID]:18669018
[Au] Autor:Viveros-Valdez E; Rivas-Morales C; Carranza-Rosales P; Mendoza S; Schmeda-Hirschmann G
[Ad] Endereço:Departamento de Química, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico.
[Ti] Título:Free radical scavengers from the Mexican herbal tea "poleo" (Hedeoma drummondii).
[So] Source:Z Naturforsch C;63(5-6):341-6, 2008 May-Jun.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aerial parts of the Lamiaceae Hedeoma drummondii (Benth.) are used in Mexico to prepare a herbal tea and by North American Amerindians as a spice. The methanolic extract of the aerial parts exhibited a strong antioxidant effect measured by the scavenging of the free diphenyl picrylhydrazyl (DPPH) radical. Assay-guided fractionation of the crude methanolic extract allowed the identification of three major active constituents, chlorogenic, caffeic and rosmarinic acid, as well as sideritoflavone derivatives and simple phenolics. The TEAC, FRAP, total phenolic and flavonoid content were determined. The high content of caffeic acid and rosmarinic acid relates to the antioxidant activity of H. drummondii.
[Mh] Termos MeSH primário: Depuradores de Radicais Livres/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Hedeoma/química
[Mh] Termos MeSH secundário: Bebidas/análise
Flavonoides/química
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Fenóis/química
Fenóis/isolamento & purificação
Fenóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Phenols)
[Em] Mês de entrada:0808
[Cu] Atualização por classe:091104
[Lr] Data última revisão:
091104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080802
[St] Status:MEDLINE


  7 / 9 MEDLINE  
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[PMID]:16373019
[Au] Autor:López-Briz E; Garrigues-Gil V
[Ti] Título:[Hepatitis due to Chinese herbs].
[Ti] Título:Hepatitis por hierbas chinas..
[So] Source:Gastroenterol Hepatol;28(10):656, 2005 Dec.
[Is] ISSN:0210-5705
[Cp] País de publicação:Spain
[La] Idioma:spa
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/etiologia
Medicamentos de Ervas Chinesas/efeitos adversos
Hedeoma/efeitos adversos
Mentha pulegium/efeitos adversos
[Mh] Termos MeSH secundário: Bebidas/efeitos adversos
Bebidas/análise
Biotransformação
Seres Humanos
Óleos Vegetais/efeitos adversos
Óleos Vegetais/química
Solubilidade
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Plant Oils)
[Em] Mês de entrada:0605
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051224
[St] Status:MEDLINE


  8 / 9 MEDLINE  
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[PMID]:15104077
[Ti] Título:Dangerous supplements: still at large.
[So] Source:Consum Rep;69(5):12-7, 2004 May.
[Is] ISSN:0010-7174
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Segurança de Produtos ao Consumidor
Suplementos Nutricionais/efeitos adversos
[Mh] Termos MeSH secundário: Publicidade como Assunto
Androstenodiona/efeitos adversos
Ácidos Aristolóquicos/efeitos adversos
Confrei/efeitos adversos
Hedeoma/efeitos adversos
Seres Humanos
Kava/efeitos adversos
Pausinystalia/efeitos adversos
Rotulagem de Produtos
Scutellaria/efeitos adversos
Teucrium/efeitos adversos
Estados Unidos
United States Food and Drug Administration
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aristolochic Acids); 409J2J96VR (Androstenedione)
[Em] Mês de entrada:0405
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:040424
[St] Status:MEDLINE


  9 / 9 MEDLINE  
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[PMID]:14525732
[Au] Autor:Sztajnkrycer MD; Otten EJ; Bond GR; Lindsell CJ; Goetz RJ
[Ad] Endereço:Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA. sztajnkrycer.matthew@mayo.edu
[Ti] Título:Mitigation of pennyroyal oil hepatotoxicity in the mouse.
[So] Source:Acad Emerg Med;10(10):1024-8, 2003 Oct.
[Is] ISSN:1069-6563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Pennyroyal oil ingestion has been associated with severe hepatotoxicity and death. The primary constituent, R-(+)-pulegone, is metabolized via hepatic cytochrome P450 to toxic intermediates. The purpose of this study was to assess the ability of the specific cytochrome P450 inhibitors disulfiram and cimetidine to mitigate hepatotoxicity in mice exposed to toxic levels of R-(+)-pulegone. METHODS: 20-g female BALB/c mice were pretreated with either 150 mg/kg of cimetidine intraperitoneal (IP), 100 mg/kg of disulfiram IP, or both. After one hour, mice were administered 300 mg/kg of pulegone IP and were killed 24 hours later. Data were analyzed using ANOVA. Post-hoc t-tests used Bonferroni correction. RESULTS: There was a tendency for lower serum glutamate pyruvate transaminase in the disulfiram and cimetidine groups compared with the R-(+)-pulegone group. The differences were significant for both the cimetidine and the combined disulfram and cimetidine groups compared with the R-(+)-pulegone group. Pretreatment with the combination of disulfiram and cimetidine most effectively mitigated R-(+)-pulegone-induced hepatotoxicity. CONCLUSIONS: Within the limitations of a pretreatment animal model, the combination of cimetidine and disulfiram significantly mitigates the effects of pennyroyal toxicity and does so more effectively than either agent alone. These data suggest that R-(+)-pulegone metabolism through CYP1A2 appears to be more important in the development of a hepatotoxic metabolite than does metabolism via CYP2E1.
[Mh] Termos MeSH primário: Cimetidina/uso terapêutico
Cicloexanonas/envenenamento
Dissulfiram/uso terapêutico
Inibidores Enzimáticos/uso terapêutico
Hepatopatias/prevenção & controle
Monoterpenos/envenenamento
Óleos Voláteis/envenenamento
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Modelos Animais de Doenças
Feminino
Hedeoma
Hepatopatias/etiologia
Mentha pulegium
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexanones); 0 (Enzyme Inhibitors); 0 (Monoterpenes); 0 (Oils, Volatile); 4LF2673R3G (pulegone); 80061L1WGD (Cimetidine); AK85U7Y3MV (pennyroyal oil); TR3MLJ1UAI (Disulfiram)
[Em] Mês de entrada:0403
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031004
[St] Status:MEDLINE



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