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Pesquisa : B01.650.940.800.575.912.250.583.520.297 [Categoria DeCS]
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[PMID]:28417946
[Au] Autor:Feitosa-Alcantara RB; Bacci L; Blank AF; Alves PB; Silva IMA; Soares CA; Sampaio TS; Nogueira PCL; Arrigoni-Blank MF
[Ad] Endereço:Departamento de Engenharia Agronômica, Universidade Federal de Sergipe, São Cristóvão, SE 49100-000, Brazil. rosana.barroso@hotmail.com.
[Ti] Título:Essential Oils of Hyptis pectinata Chemotypes: Isolation, Binary Mixtures and Acute Toxicity on Leaf-Cutting Ants.
[So] Source:Molecules;22(4), 2017 Apr 12.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Leaf-cutting ants are pests of great economic importance due to the damage they cause to agricultural and forest crops. The use of organosynthetic insecticides is the main form of control of these insects. In order to develop safer technology, the objective of this work was to evaluate the formicidal activity of the essential oils of two genotypes (chemotypes) and their major compounds on the leaf-cutting ants Emery and Forel. Bioassays of exposure pathways (contact and fumigation) and binary mixtures of the major compounds were performed. The major compounds identified in the essential oils of were ß-caryophyllene, caryophyllene oxide and calamusenone. The essential oils of were toxic to the ants in both exposure pathways. Essential oils were more toxic than their major compounds alone. The chemotype calamusenone was more toxic to in both exposure pathways. was more susceptible to the essential oil of the chemotype ß-caryophyllene in both exposure pathways. In general, the binary mixtures of the major compounds resulted in additive effect of toxicity. The essential oils of is a raw material of great potential for the development of new insecticides.
[Mh] Termos MeSH primário: Formigas/efeitos dos fármacos
Hyptis/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Animais
Óleos Voláteis/isolamento & purificação
Compostos Fitoquímicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Phytochemicals)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28243983
[Au] Autor:da Silva IP; Brissow E; Kellner Filho LC; Senabio J; de Siqueira KA; Vandresen Filho S; Damasceno JL; Mendes SA; Tavares DC; Magalhães LG; Junior PA; Januário AH; Soares MA
[Ad] Endereço:Department of Botany and Ecology, Institute of Biosciences, Federal University of Mato Grosso, Cuiabá, MT, Brazil.
[Ti] Título:Bioactive compounds of Aspergillus terreus-F7, an endophytic fungus from Hyptis suaveolens (L.) Poit.
[So] Source:World J Microbiol Biotechnol;33(3):62, 2017 Mar.
[Is] ISSN:1573-0972
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The compounds terrein (1), butyrolactone I (2), and butyrolactone V (3) were isolated from the ethyl acetate extract (EtOAc) of the endophytic fungus Aspergillus terreus-F7 obtained from Hyptis suaveolens (L.) Poit. The extract and the compounds presented schistosomicidal activity against Schistosoma mansoni; at 100 µg/mL for EtOAc extract, 1297.3 µM for compound 1, 235.6 µM for compound 2, and 454.1 µM for compound 3, they killed 100% of the parasites after 72 h of treatment. Compounds 1, 2, and 3 exerted moderate leishmanicidal activity against Leishmania amazonensis (IC ranged from 23.7 to 78.6 µM). At 235.6 and 227.0 µM, compounds 2 and 3, respectively, scavenged 95.92 and 95.12% of the DPPH radical (2,2-diphenyl-1-picryl-hydrazyl), respectively. Regarding the cytotoxicity against the breast tumor cell lines MDA-MB-231 and MCF-7, compound 2 gave IC of 34.4 and 17.4 µM, respectively, while compound 3 afforded IC of 22.2 and 31.9 µM, respectively. At 117.6 µM, compound 2 inhibited the growth of and killed the pathogen Escherichia coli (ATCC 25922). Compounds 1, 2, and 3 displayed low toxicity against the normal line of human lung fibroblasts (GM07492A cells), with IC of 15.3 × 10 , 3.4 × 10 , and 5.8 × 10 µM, respectively. This is the first report on (i) the in vitro schistosomicidal and leishmanicidal activities of the EtOAc extract of A. terreus-F7 and compounds 1, 2, and 3; and (ii) the antitumor activity of compounds 2 and 3 against MDA-MB-231 and MCF-7 cells.
[Mh] Termos MeSH primário: Aspergillus/química
Ciclopentanos/farmacologia
Furanos/farmacologia
Hyptis/microbiologia
Lactonas/farmacologia
[Mh] Termos MeSH secundário: 4-Butirolactona/análogos & derivados
4-Butirolactona/isolamento & purificação
Animais
Anti-Helmínticos/isolamento & purificação
Anti-Helmínticos/farmacologia
Antineoplásicos/isolamento & purificação
Antineoplásicos/farmacologia
Antiprotozoários/isolamento & purificação
Antiprotozoários/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Ciclopentanos/isolamento & purificação
Endófitos/metabolismo
Furanos/isolamento & purificação
Seres Humanos
Lactonas/isolamento & purificação
Leishmania/efeitos dos fármacos
Células MCF-7
Schistosoma/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Antineoplastic Agents); 0 (Antiprotozoal Agents); 0 (Cyclopentanes); 0 (Furans); 0 (Lactones); 3I47HPE16N (terrein); 87414-49-1 (butyrolactone I); OL659KIY4X (4-Butyrolactone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1007/s11274-017-2228-3


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[PMID]:28213106
[Au] Autor:Simões RR; Coelho ID; Junqueira SC; Pigatto GR; Salvador MJ; Santos AR; de Faria FM
[Ad] Endereço:Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina - UFSC, Florianópolis, Santa Catarina, Brazil; Laboratório de Neurobiologia da Dor e Inflamação, Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina - UFSC, Flo
[Ti] Título:Oral treatment with essential oil of Hyptis spicigera Lam. (Lamiaceae) reduces acute pain and inflammation in mice: Potential interactions with transient receptor potential (TRP) ion channels.
[So] Source:J Ethnopharmacol;200:8-15, 2017 Mar 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The genus Hyptis comprehends almost 400 species widespread in tropical and temperate regions of America. The use of Hyptis spicigera Lam. (Lamiaceae) is reported in traditional medicine due to its gastroprotective, anti-inflammatory and analgesic properties. AIM OF THE STUDY: The rationale of this study was to investigate the potential use of the essential oil of H. spicigera (EOHs) as analgesic. MATERIAL AND METHODS: The antinociceptive effect of EOHs was verified analyzing acute nocifensive behavior of mice induced by chemical noxious stimuli [i.e., formalin and transient receptor potential (TRP) channels agonists]. We also verified the effects of EOHs on locomotor activity and motor performance in mice. Finally, we investigate the involvement of central afferent C-fibers with EOHs analgesic effect. RESULTS: EOHs presented antinociceptive effect at 300 and 1000mg/kg on formalin-induced pain behavior model, presenting 50% and 72% of inhibition during the first phase (ED =292mg/kg), and 85% and 100% during de second phase (ED =205mg/kg), respectively. Temperature of the hind paw was reduced by EOHs treatment in a dose-dependent manner; oedema was diminished only by EOHs 1000mg/kg. EOHs does not impaired locomotor activity or motor performance. For mice injected with capsaicin, a TRPV1 activator, EOHs (1000mg/kg, ED =660mg/kg) showed decreased (63%) nociceptive behavior. When injected with cinnamaldehyde (TRPA1 activator), mice treated with EOHs showed 23%, 43% and 66% inhibition on nociceptive behavior (100, 300 and 1000mg/kg, respectively; ED 402mg/kg). When mice were injected with menthol (TRPM8 activator), EOHs showed 29%, 59% and 98% inhibition of nociceptive behavior (100, 300 and 1000mg/kg, respectively; with ED =198mg/kg. Finally, when desensitized mice were injected with menthol, EOHs (300mg/kg) does not show antinociceptive effect. CONCLUSIONS: This study demonstrated the efficacy of EOHs on experimental models of nociception. We have found the involvement of TRP channels V1, A1 and M8 with EOHs activity, which was remarkably potent and efficient in inhibiting pain evoked by menthol, a TRPM8 channel activator. TRPM8 channels from TRPV1+ C-fibers, but not TRPM8+ C-fibers nor TRPM8+ Aδ mechanosensory fibers, mediate EOHs analgesic effects.
[Mh] Termos MeSH primário: Dor Aguda/tratamento farmacológico
Analgésicos/administração & dosagem
Anti-Inflamatórios/administração & dosagem
Hyptis
Óleos Voláteis/administração & dosagem
Canais de Receptores Transientes de Potencial/agonistas
[Mh] Termos MeSH secundário: Dor Aguda/metabolismo
Administração Oral
Analgésicos/isolamento & purificação
Animais
Anti-Inflamatórios/isolamento & purificação
Relação Dose-Resposta a Droga
Feminino
Inflamação/tratamento farmacológico
Inflamação/metabolismo
Lamiaceae
Camundongos
Óleos Voláteis/isolamento & purificação
Medição da Dor/efeitos dos fármacos
Medição da Dor/métodos
Canais de Receptores Transientes de Potencial/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Oils, Volatile); 0 (Transient Receptor Potential Channels)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:28099005
[Au] Autor:Suárez-Ortiz GA; Cerda-García-Rojas CM; Fragoso-Serrano M; Pereda-Miranda R
[Ad] Endereço:Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Circuito Exterior Ciudad Universitaria , Mexico City 04510, Mexico.
[Ti] Título:Complementarity of DFT Calculations, NMR Anisotropy, and ECD for the Configurational Analysis of Brevipolides K-O from Hyptis brevipes.
[So] Source:J Nat Prod;80(1):181-189, 2017 Jan 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brevipolides K-O (1-5), five new cytotoxic 6-(6'-cinnamoyloxy-2',5'-epoxy-1'-hydroxyheptyl)-5,6-dihydro-2H-pyran-2-ones (IC values against six cancer cell lines, 1.7-10 µM), were purified by recycling HPLC from Hyptis brevipes. The structures, containing a distinctive tetrahydrofuran ring, were established by comprehensive quantum mechanical calculations and experimental spectroscopic analysis of their NMR and ECD data. Detailed analysis of the experimental NMR H- H vicinal coupling constants in comparison with the corresponding DFT-calculated values at the B3LYP/DGDZVP level confirmed the absolute configuration of 3 and revealed its conformational preferences, which were further strengthened by NOESY correlations. NMR anisotropy experiments by the application of Mosher's ester methodology and chemical correlations were also used to conclude that this novel brevipolide series (1-5) share the same absolute configuration corresponding to C-6(R), C-1'(S), C-2'(R), C-5'(S), and C-6'(S).
[Mh] Termos MeSH primário: Hyptis/química
Pironas/isolamento & purificação
[Mh] Termos MeSH secundário: Anisotropia
Linhagem Celular
Seres Humanos
Concentração Inibidora 50
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Pironas/química
Pironas/farmacologia
Teoria Quântica
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pyrones)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00953


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[PMID]:27979234
[Au] Autor:Mueller M; Cavarkapa A; Unger FM; Viernstein H; Praznik W
[Ad] Endereço:Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. Electronic address: monika.mueller@univie.ac.at.
[Ti] Título:Prebiotic potential of neutral oligo- and polysaccharides from seed mucilage of Hyptis suaveolens.
[So] Source:Food Chem;221:508-514, 2017 Apr 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Prebiotics are selectively fermented by the gastrointestinal microflora, resulting in benefits to human health. The seed mucilage of Hyptis suaveolens contains neutral and acidic polysaccharides in a ratio of 1:1. The neutral polysaccharides consist of galactose, glucose and mannose whereas the acidic polysaccharides contain fucose, xylose and 4-O-methylglucuronic acid -residues. The growth of probiotics in the presence of total, acidic or neutral polysaccharides and oligosaccharides was tested using turbidity measurements. The majority (11 out of 14) of the tested probiotic strains significantly grew in the neutral fraction. Growth occurred with some time delay, but may be longer lasting than with other lower molecular prebiotics. The extent of growth increased with neutral polysaccharides from H. suaveolens corresponding to the externally available galactose units (20%). In conclusion, neutral poly- and oligosaccharides from H. suaveolens have a prebiotic potential characterized by a delayed but long lasting effect.
[Mh] Termos MeSH primário: Hyptis/química
Oligossacarídeos/análise
Polissacarídeos/análise
Prebióticos/análise
Sementes/química
[Mh] Termos MeSH secundário: Fermentação/fisiologia
Galactose/análise
Galactose/metabolismo
Seres Humanos
Hyptis/metabolismo
Manose/análise
Manose/metabolismo
Oligossacarídeos/metabolismo
Polissacarídeos/metabolismo
Probióticos/análise
Probióticos/metabolismo
Sementes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oligosaccharides); 0 (Polysaccharides); 0 (Prebiotics); PHA4727WTP (Mannose); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27979191
[Au] Autor:Praznik W; Cavarkapa A; Unger FM; Loeppert R; Holzer W; Viernstein H; Mueller M
[Ad] Endereço:Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. Electronic address: werner.praznik@univie.ac.at.
[Ti] Título:Molecular dimensions and structural features of neutral polysaccharides from the seed mucilage of Hyptis suaveolens L.
[So] Source:Food Chem;221:1997-2004, 2017 Apr 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The seed mucilage of Hyptis suaveolens L. includes acid - and neutral heteropolysaccharides in a ratio of about 1:1. The anionic charged fraction responsible for swelling and viscous behaviour possesses an average molar mass of Mw=350kg/mol, Mn=255kg/mol. The neutral polysaccharide fraction shows an average molar mass of Mw=47kg/mol and Mn=28kg/mol and is composed of d-Galp-, d-Glcp- and d-Manp residues in a molar ratio of about 3:2:1. The structural features present galactoglucan (30%) and galactoglucomannan (70%) with a high level of terminal ß-linked d-Galp residues (18%). Structural details of galactoglucomannan are derived by combined enzymatic and chemical methods as well as NMR spectroscopy. Sequences of octa/nonasaccharide ß-d-Glcp-(1→4)[ß-d-Galp-(1→2)-α-d-Galp-(1→6)]-ß-d-Manp-(1→4)-ß-d-Glcp-(1→4)-ß-d-Glcp-(1→4)[ß-d-Galp-(1→2)-α-d-Galp-(1→6)]-ß-d-Manp and lower mass tetrasaccharide repeating units ß-d-Glcp-(1→4)[ß-d-Galp-(1→2)-α-d-Galp-(1→6)]-ß-d-Manp were found. The level of the prebiotic activity is related to the availability of ß-linked d-Galp residues in the side chains of the molecules.
[Mh] Termos MeSH primário: Hyptis/química
Oligossacarídeos/química
Polissacarídeos/química
Sementes/química
[Mh] Termos MeSH secundário: Galactanos/química
Glucanos/química
Espectroscopia de Ressonância Magnética
Mananas/química
Estrutura Molecular
Peso Molecular
Polissacarídeos Bacterianos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Galactans); 0 (Glucans); 0 (Mannans); 0 (Oligosaccharides); 0 (Polysaccharides); 0 (Polysaccharides, Bacterial); 0 (galactoglucomannan); 55787-15-0 (galactoglucan)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


  7 / 90 MEDLINE  
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Soares, Célia Maria de Almeida
PubMed Central Texto completo
Texto completo
[PMID]:26734764
[Au] Autor:Araújo FS; Coelho LM; Silva Ldo C; da Silva Neto BR; Parente-Rocha JA; Bailão AM; de Oliveira CM; Fernandes Gda R; Hernández O; Ochoa JG; Soares CM; Pereira M
[Ad] Endereço:Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
[Ti] Título:Effects of Argentilactone on the Transcriptional Profile, Cell Wall and Oxidative Stress of Paracoccidioides spp.
[So] Source:PLoS Negl Trop Dis;10(1):e0004309, 2016 Jan.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Paracoccidioides spp., a dimorphic pathogenic fungus, is the etiologic agent of paracoccidioidomycosis (PCM). PCM is an endemic disease that affects at least 10 million people in Latin America, causing severe public health problems. The drugs used against pathogenic fungi have various side effects and limited efficacy; therefore, there is an inevitable and urgent medical need for the development of new antifungal drugs. In the present study, we evaluated the transcriptional profile of Paracoccidioides lutzii exposed to argentilactone, a constituent of the essential oil of Hyptis ovalifolia. A total of 1,058 genes were identified, of which 208 were up-regulated and 850 were down-regulated. Cell rescue, defense and virulence, with a total of 26 genes, was a functional category with a large number of genes induced, including heat shock protein 90 (hsp90), cytochrome c peroxidase (ccp), the hemoglobin ligand RBT5 (rbt5) and superoxide dismutase (sod). Quantitative real-time PCR revealed an increase in the expression level of all of those genes. An enzymatic assay showed a significant increase in SOD activity. The reduced growth of Pbhsp90-aRNA, Pbccp-aRNA, Pbsod-aRNA and Pbrbt5-aRNA isolates in the presence of argentilactone indicates the importance of these genes in the response of Paracoccidioides spp. to argentilactone. The response of the P. lutzii cell wall to argentilactone treatment was also evaluated. The results showed that argentilactone caused a decrease in the levels of polymers in the cell wall. These results suggest that argentilactone is a potential candidate for antifungal therapy.
[Mh] Termos MeSH primário: Antifúngicos/metabolismo
Parede Celular/efeitos dos fármacos
Perfilação da Expressão Gênica
Lactonas/metabolismo
Estresse Oxidativo
Paracoccidioides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antifúngicos/isolamento & purificação
Hyptis/química
Lactonas/isolamento & purificação
Paracoccidioides/genética
Paracoccidioides/crescimento & desenvolvimento
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Lactones); 0 (argentilactone)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160116
[Lr] Data última revisão:
160116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160107
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0004309


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[PMID]:26304339
[Au] Autor:Bojórquez-Velázquez E; Lino-López GJ; Huerta-Ocampo JA; Barrera-Pacheco A; Barba de la Rosa AP; Moreno A; Mancilla-Margalli NA; Osuna-Castro JA
[Ad] Endereço:Departamento de Ingeniería Química y Bioquímica, Instituto Tecnológico de Los Mochis, Los Mochis, Sinaloa CP 81250, Mexico; IPICyT, Instituto Potosino de Investigación Científica y Tecnológica A.C., Camino a la Presa San José No. 2055, Lomas 4a Sección, San Luis Potosí, SLP CP 78216, Mexico; Faculta
[Ti] Título:Purification and biochemical characterization of 11S globulin from chan (Hyptis suaveolens L. Poit) seeds.
[So] Source:Food Chem;192:203-11, 2016 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chan (Hyptis suaveolens) is a Mesoamerican crop highly appreciated since the pre-Hispanic cultures. Its proteins are a good source of essential amino acids; however, there are no reports on the properties of its individual proteins. In this study, the 11S globulin (Hs11S) was purified and biochemically characterized. The molecular weight of native Hs11S was about 150-300 kDa with isoelectric points of 5.0-5.3, composed by four monomers of 53.5, 52, 51.1 and 49.5 kDa, each formed by one acidic subunit and one basic subunit linked by a disulfide bond. Dynamic light scattering, size exclusion chromatography and native PAGE show that Hs11S is assembled in different oligomeric forms. LC-MS/MS analysis confirmed its identity. Hs11S presents antigenic determinants in common with lupin 11S globulin. Carbohydrate moieties or phosphate groups linked to Hs11S were not detected. This information is very useful in order to exploit and utilize rationally chan 11S globulin in food systems.
[Mh] Termos MeSH primário: Globulinas/isolamento & purificação
Hyptis/química
Proteínas de Armazenamento de Sementes/isolamento & purificação
Sementes/química
[Mh] Termos MeSH secundário: Eletroforese em Gel de Poliacrilamida
Ponto Isoelétrico
Peso Molecular
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Globulins); 0 (Seed Storage Proteins)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150825
[Lr] Data última revisão:
150825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150826
[St] Status:MEDLINE


  9 / 90 MEDLINE  
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[PMID]:26669118
[Au] Autor:Flores M; Rojas L; Aparicio R; Lucena ME; Usubillaga A
[Ti] Título:Essential Oil Composition and Antibacterial Activity of Hyptis colombiana from the Venezuelan Andes.
[So] Source:Nat Prod Commun;10(10):1751-2, 2015 Oct.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hyptis colombiana is an aromatic shrub native to the Colombian and Venezuelan Andes. Aerial parts were collected in Mérida State at about 3100 m above sea level in February 2005, and May and October 2006. The essential oil was found to contain germacrene D and ß-caryophyllene as main constituents (about 50%). The February 2005 and October 2006 oils were found to have antibacterial activity against Staphylococcus aureus, but not the May 2006 oil, probably due to the lack of some minor constituent.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Bactérias/efeitos dos fármacos
Hyptis
Óleos Voláteis/química
Componentes Aéreos da Planta
Óleos Vegetais/química
Venezuela
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151216
[Lr] Data última revisão:
151216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151217
[St] Status:MEDLINE


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[PMID]:26385208
[Au] Autor:Ashitani T; Garboui SS; Schubert F; Vongsombath C; Liblikas I; Pålsson K; Borg-Karlson AK
[Ad] Endereço:Department of Bioenviroment, Faculty of Agriculture, Yamagata University, 1-23 Wakaba-Machi, Tsuruoka, Yamagata, 997-8555, Japan.
[Ti] Título:Activity studies of sesquiterpene oxides and sulfides from the plant Hyptis suaveolens (Lamiaceae) and its repellency on Ixodes ricinus (Acari: Ixodidae).
[So] Source:Exp Appl Acarol;67(4):595-606, 2015 Dec.
[Is] ISSN:1572-9702
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hyptis suaveolens (Lamiaceae), a plant traditionally used as a mosquito repellent, has been investigated for repellent properties against nymphs of the tick Ixodes ricinus. Essential oils and volatile compounds of fresh and dried leaves, from plants originating from Laos and Guinea-Bissau, were identified by GC-MS and tested in a tick repellency bioassay. All the essential oils were strongly repellent against the ticks, even though the main volatile constituents differed in their proportions of potentially tick repellent chemicals. (+)/(-)-sabinene were present in high amounts in all preparations, and dominated the emission from dry and fresh leaves together with 1,8-cineol and α-phellandrene. 1,8-Cineol and sabinene were major compounds in the essential oils from H. suaveolens from Laos. Main compounds in H. suaveolens from Guinea-Bissau were (-)-sabinene, limonene and terpinolene. Among the sesquiterpene hydrocarbons identified, α-humulene exhibited strong tick repellency (96.8 %). Structure activity studies of oxidation or sulfidation products of germacrene D, α-humulene and ß-caryophyllene, showed increased tick repellent activity: of mint sulfide (59.4 %), humulene-6,7-oxide (94.5 %) and caryophyllene-6,7-oxide (96.9 %). The substitution of oxygen with sulfur slightly lowered the repellency. The effects of the constituents in the oils can then be regarded as a trade off between the subsequently lower volatility of the sesquiterpene derivatives compared to the monoterpenes and may thus increase their potential usefulness as tick repellents.
[Mh] Termos MeSH primário: Acaricidas
Hyptis/química
Ixodes
Óleos Voláteis
Sesquiterpenos
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa-Espectrometria de Massas
Guiné-Bissau
Laos
Óxidos
Extratos Vegetais/química
Folhas de Planta/química
Sulfetos
Controle de Ácaros e Carrapatos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acaricides); 0 (Oils, Volatile); 0 (Oxides); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Sulfides)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150920
[St] Status:MEDLINE
[do] DOI:10.1007/s10493-015-9965-5



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