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Pesquisa : B01.650.940.800.575.912.250.583.520.455 [Categoria DeCS]
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  1 / 31 MEDLINE  
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[PMID]:29441920
[Ti] Título:Pancreatic lipase and -amylase inhibitory activities of plants used in Traditional Chinese Medicine (TCM).
[So] Source:Pharmazie;71(7):420-424, 2016 Jul 07.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:To find new, plant based drugs for the treatment of obesity and/or diabetes mellitus type 2 through the inhibition of essential digestive enzymes, in vitro tests were carried out on selected plants or fungi with weight-reducing, blood glucose-reducing or related potential, used in Traditional Chinese Medicine (TCM). Aqueous and methanolic extracts of 32 Chinese herbal medicines were assayed for their in vitro inhibitory activity against pancreatic lipase (PL) and α-amylase (PA). PL activity was measured by using an enzymatic in vitro assay based on the hydrolysis kinetics of an oleate ester of 4-methylumbelliferone. For the determination of α-amylase activity an enzyme assay based on the hydrolytic cleavage of a modified starch derivative was used. Our findings have shown that the methanolic extract of Lycopus lucidus Turcz. var. hirtus Regel (Lamiaceae) was a very effective PL inhibitor (IC50: 88.3±4.1 µg/mL). A high anti-amylase activity showed the methanolic extract of Trichosanthes kirilowii Maxim. (Curcurbitaceae, IC50: 248.8±67.3 µg/mL). This work provides a priority list of interesting plants for further study with respect to the treatment of obesity and associated metabolic diseases.
[Mh] Termos MeSH primário: Lipase/antagonistas & inibidores
Pâncreas/enzimologia
Plantas/química
alfa-Amilases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Fungos/química
Hidrólise
Himecromona/química
Cinética
Lycopus/química
Medicina Tradicional Chinesa
Pâncreas/efeitos dos fármacos
Extratos Vegetais/farmacologia
Trichosanthes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 3T5NG4Q468 (Hymecromone); EC 3.1.1.3 (Lipase); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6569


  2 / 31 MEDLINE  
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[PMID]:27739081
[Au] Autor:Ren Q; Ding L; Sun SS; Wang HY; Qu L
[Ad] Endereço:Department of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
[Ti] Título:Chemical identification and quality evaluation of Lycopus lucidus Turcz by UHPLC-Q-TOF-MS and HPLC-MS/MS and hierarchical clustering analysis.
[So] Source:Biomed Chromatogr;31(5), 2017 May.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lycopus lucidus Turcz has been used as a traditional phytomedicine for menstrual disorder, amenorrhea, menstrual cramps, inflammation and cardiovascular diseases. However, there is not enough information about identification and quantification for the chemical constituents of L. lucidus Turcz. In this work, a simple, rapid and sensitive UHPLC-Q-TOF-MS method was developed for characterization and identification of the phytochemical compositions in L. lucidus Turcz in negative ion mode. A total of 37 compounds, including 15 phenolic acids, 12 flavonoids, three triterpenoids and seven organic acids were tentatively characterized and identified by means of the retention time, accurate mass and characteristic fragment ions. Thirteen compounds were reported for the first time in L. lucidus Turcz. Among of them, 11 compounds were further quantified by multiple reactions monitoring. The results showed good performance with respect to linearity (r > 0.9959), repeatability (RSD < 2.6%), intra- and inter-day precision (RSD < 3.2%), recovery (93.1-104.9%), and lower limit of quantification (5-50 ng/mL). Subsequently, the results were analyzed and classified by hierarchical cluster analysis. The research could be applied for identification and quality evaluation for L. lucidus Turcz.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/química
Lycopus/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Calibragem
China
Análise por Conglomerados
Medicamentos de Ervas Chinesas/análise
Flavonoides/análise
Fenóis/análise
Controle de Qualidade
Reprodutibilidade dos Testes
Triterpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Phenols); 0 (Triterpenes)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3867


  3 / 31 MEDLINE  
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[PMID]:27262082
[Au] Autor:Ren Q; Wang YL; Wang ML; Wang HY
[Ad] Endereço:Department of Pharmacy, Jining Medical University, Rizhao, Shandong, China. Electronic address: ren2323@163.com.
[Ti] Título:Screening and identification of the metabolites in rat urine and feces after oral administration of Lycopus lucidus Turcz extract by UHPLC-Q-TOF-MS mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1027:64-73, 2016 Aug 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Lycopus lucidus Turcz has been used as a kind of edible and medicinal material in eastern Asian countries. It has various bioactivities, including treatment of menstrual disorder, amenorrhea, menstrual cramps, inflammation, and cardiovascular diseases. However, the in vivo metabolism of L. lucidus Turcz extract is still not well described. In this study, L. lucidus Turcz extracts were administered to rats. Urine and fecal samples were collected at the difference periods (0-12h, 12-24h, and 24-36h). Ultra-high performance liquid chromatography coupled with electrospray ionization tandem quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed to characterize and identify the metabolites. A total of 17 metabolites in feces and 19 metabolites in urine were tentatively identified by means of accurate mass and characteristic fragment ions. The results show that glucuronidation and sulfation are the major metabolic reactions. This study is the first reported analysis and characterization of the metabolites and the proposed metabolic pathways of bioactive components might provide further understanding of the metabolic fate of the chemical constituents after oral administration of L. lucidus Turcz extract in rats.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/metabolismo
Fezes/química
Lycopus/metabolismo
Metabolômica/métodos
Urina/química
[Mh] Termos MeSH secundário: Administração Oral
Animais
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/química
Feminino
Lycopus/química
Redes e Vias Metabólicas
Ratos
Ratos Wistar
Espectrometria de Massas por Ionização por Electrospray/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


  4 / 31 MEDLINE  
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[PMID]:26486611
[Au] Autor:Favre-Bac L; Mony C; Ernoult A; Burel F; Arnaud JF
[Ad] Endereço:UMR CNRS 6553 ECOBIO, Université de Rennes 1, Campus de Beaulieu, Rennes Cedex, France.
[Ti] Título:Ditch network sustains functional connectivity and influences patterns of gene flow in an intensive agricultural landscape.
[So] Source:Heredity (Edinb);116(2):200-12, 2016 Feb.
[Is] ISSN:1365-2540
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In intensive agricultural landscapes, plant species previously relying on semi-natural habitats may persist as metapopulations within landscape linear elements. Maintenance of populations' connectivity through pollen and seed dispersal is a key factor in species persistence in the face of substantial habitat loss. The goals of this study were to investigate the potential corridor role of ditches and to identify the landscape components that significantly impact patterns of gene flow among remnant populations. Using microsatellite loci, we explored the spatial genetic structure of two hydrochorous wetland plants exhibiting contrasting local abundance and different habitat requirements: the rare and regionally protected Oenanthe aquatica and the more commonly distributed Lycopus europaeus, in an 83 km(2) agricultural lowland located in northern France. Both species exhibited a significant spatial genetic structure, along with substantial levels of genetic differentiation, especially for L. europaeus, which also expressed high levels of inbreeding. Isolation-by-distance analysis revealed enhanced gene flow along ditches, indicating their key role in effective seed and pollen dispersal. Our data also suggested that the configuration of the ditch network and the landscape elements significantly affected population genetic structure, with (i) species-specific scale effects on the genetic neighborhood and (ii) detrimental impact of human ditch management on genetic diversity, especially for O. aquatica. Altogether, these findings highlighted the key role of ditches in the maintenance of plant biodiversity in intensive agricultural landscapes with few remnant wetland habitats.
[Mh] Termos MeSH primário: Ecossistema
Fluxo Gênico
Genética Populacional
Lycopus/genética
Oenanthe/genética
[Mh] Termos MeSH secundário: Agricultura
França
Variação Genética
Genótipo
Geografia
Desequilíbrio de Ligação
Repetições de Microssatélites
Análise Espacial
Zonas Úmidas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151022
[St] Status:MEDLINE
[do] DOI:10.1038/hdy.2015.90


  5 / 31 MEDLINE  
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[PMID]:26011699
[Au] Autor:Liang T; Fu Q; Li F; Zhou W; Xin H; Wang H; Jin Y; Liang X
[Ad] Endereço:Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, PR, China.
[Ti] Título:Hydrophilic interaction liquid chromatography for the separation, purification, and quantification of raffinose family oligosaccharides from Lycopus lucidus Turcz.
[So] Source:J Sep Sci;38(15):2607-13, 2015 Aug.
[Is] ISSN:1615-9314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A systematic strategy based on hydrophilic interaction liquid chromatography was developed for the separation, purification and quantification of raffinose family oligosaccharides from Lycopus lucidus Turcz. Methods with enough hydrophilicity and selectivity were utilized to resolve the problems encountered in the separation of oligosaccharides such as low retention, low resolution and poor solubility. The raffinose family oligosaccharides in L. lucidus Turcz. were isolated using solid-phase extraction followed by hydrophilic interaction liquid chromatography at semi-preparative scale to obtain standards of stachyose, verbascose and ajugose. Utilizing the obtained oligosaccharides as standards, a quantitative determination method was developed, validated and applied for the content determination of raffinose family oligosaccharides both in the aerial and root parts of L. lucidus Turcz. There were no oligosaccharides in the aerial parts, while in the root parts, the total content was 686.5 mg/g with the average distribution: raffinose 66.5 mg/g, stachyose 289.0 mg/g, verbascose 212.4 mg/g, and ajugose 118.6 mg/g. The result provided the potential of roots of L. lucidus Turcz. as new raffinose family oligosaccharides sources for functional food. Moreover, since the present systematic strategy is efficient, sensitive and robust, separation, purification and quantification of oligosaccharides by hydrophilic interaction liquid chromatography seems to be possible.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Lycopus/química
Oligossacarídeos/isolamento & purificação
Rafinose/química
[Mh] Termos MeSH secundário: Interações Hidrofóbicas e Hidrofílicas
Oligossacarídeos/química
Microextração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Oligosaccharides); N5O3QU595M (Raffinose)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150723
[Lr] Data última revisão:
150723
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150527
[St] Status:MEDLINE
[do] DOI:10.1002/jssc.201500316


  6 / 31 MEDLINE  
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[PMID]:25863615
[Au] Autor:Lu YH; Huang JH; Li YC; Ma TT; Sang P; Wang WJ; Gao CY
[Ad] Endereço:College of Agronomy and Biological Science, Dali University, Dali 671003, China.
[Ti] Título:Variation in nutritional compositions, antioxidant activity and microstructure of Lycopus lucidus Turcz. root at different harvest times.
[So] Source:Food Chem;183:91-100, 2015 Sep 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to investigate the variation in nutritional compositions, antioxidant activity and microstructure of Lycopus lucidus Turcz. root at different harvest times. L. lucidus Turcz. roots, harvested from two sites (S1 and S2) at three different times (T1: 19-11-2013, T2: 22-12-2013 and T3: 27-01-2014), were analyzed for nutritional compositions, antioxidant activity by DPPH, FRAP and TEAC assays and microstructure. The results revealed that the protein content in L. lucidus Turcz. root first decreased and then increased to a maximum at T3. The reducing sugar content had no significant differences among the three harvest dates studied. The starch content decreased drastically along with an increase of crude fat content with the harvest time delayed. The major amino acids in L. lucidus Turcz. root were aspartic acid and glutamate and the highest total amino acid content was found for the root harvested at T3. The most common element in L. lucidus Turcz. root was detected to be potassium followed by calcium, iron, magnesium, copper and manganese, and their changes were discrepant in the period of harvest. The FP and SGP possessed the highest and lowest phenolic content, respectively. The change of SEP was significantly correlated to the SGP at different harvest times. The highest TPC was found for the root harvested at T3 and the most abundant phenolic acid was chlorogenic acid. The highest and lowest DPPH radical scavenging capacity was observed for the SGP and FP, respectively. The highest and lowest FRAP and TEAC were observed for the FP and SGP, respectively. The results of correlation analysis indicated that there was significant correlation between phenolic content and FRAP and TEAC, and different antioxidant assays. The microstructure of L. lucidus Turcz. root also varied greatly with the harvest times.
[Mh] Termos MeSH primário: Antioxidantes/química
Lycopus/química
Fenóis/química
Extratos Vegetais/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150413
[Lr] Data última revisão:
150413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150413
[St] Status:MEDLINE


  7 / 31 MEDLINE  
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[PMID]:25674680
[Au] Autor:Fialová S; Slobodníková L; Veizerová L; Grancai D
[Ad] Endereço:a Department of Pharmacognosy and Botany , Faculty of Pharmacy, Comenius University in Bratislava , 832 32 Bratislava , Slovak Republic.
[Ti] Título:Lycopus europaeus: phenolic fingerprint, antioxidant activity and antimicrobial effect on clinical Staphylococcus aureus strains.
[So] Source:Nat Prod Res;29(24):2271-4, 2015.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lycopus europaeus L. leaves water extract (LEL) was subjected to phytochemical analysis, and evaluated for its antibacterial and antioxidant effects. Antibacterial activity testing was performed on Staphylococcus aureus clinical strains from catheter-related and skin infections by broth microdilution test. LEL showed bactericidal activity at concentrations from 2500 to 5000 µg/mL against all, including methicillin resistant and polyresistant nosocomial, strains. Antioxidant activity was examined using DPPH and ABTS (11.3 and 9.8 µg/mL, respectively) and by ferric reducing ability of the plasma method (891 µmol AAE/g dry extract). Phytochemical analysis of LEL was performed by LC-DAD-MS/MS. Ten phenolic compounds were identified; two minor compounds (glucopyranosyl rosmarinic acid and sagerinig acid) have not been described in Lycopus yet. The major compounds, considered to be responsible for biological activities detected in the study, were determined as rosmarinic acid (76 mg/g) and luteolin-7-O-glucuronide (23 mg/g). L. europaeus arises from our study as a promising source of antibacterial agent for topical usage.
[Mh] Termos MeSH primário: Antibacterianos/química
Antioxidantes/química
Lycopus/química
Fenóis/química
Extratos Vegetais/química
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Antioxidantes/isolamento & purificação
Testes de Sensibilidade Microbiana
Estrutura Molecular
Fenóis/isolamento & purificação
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150930
[Lr] Data última revisão:
150930
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150213
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1010086


  8 / 31 MEDLINE  
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[PMID]:24245736
[Au] Autor:Li T; Lu X; Yang X
[Ad] Endereço:Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Food Engineering and Nutritional Science, Shaanxi Normal University , Xi'an 710062, China.
[Ti] Título:Stachyose-enriched α-galacto-oligosaccharides regulate gut microbiota and relieve constipation in mice.
[So] Source:J Agric Food Chem;61(48):11825-31, 2013 Dec 04.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study probed the effects of Deshipu stachyose granules (DSG), a novel oligosaccharide preparation (55.3% stachyose, 25.8% raffinose, and 9.7% verbascose), on gut microbiota and constipation in mice. Mice were administered intragastrically without or with DSG (0.42, 0.83, and 2.49 g/kg bw), and feces were collected after 14 days of treatment and subjected to classical microbiological assays. Selective index (SI) and prebiotic index (PI) were incorporated to evaluate the prebiotic effect. DSG at 0.83 g/kg bw scored the highest SI and PI scores, thus supporting a strong prebiotic role. In addition, the impact of DSG (0.42, 0.83, and 1.68 g/kg bw) on defecation function of constipated mice was determined. Ink propulsion rate in the small intestine was significantly improved by DSG treatment. DSG supplementation also distinctly increased the weight and number of black feces within 5 h and evidently shortened the defecating time of first black feces, as compared with the constipation control mice. All of these findings indicate that DSG may promote the growth of beneficial intestinal bacteria and inhibit pathogenic bacteria and also facilitate intestinal peristalsis and fecal excretion, thereby enhancing intestinal health and relieving constipation.
[Mh] Termos MeSH primário: Constipação Intestinal/tratamento farmacológico
Trato Gastrointestinal/microbiologia
Lycopus/química
Microbiota/efeitos dos fármacos
Oligossacarídeos/administração & dosagem
Extratos Vegetais/administração & dosagem
Prebióticos/análise
[Mh] Termos MeSH secundário: Animais
Constipação Intestinal/microbiologia
Constipação Intestinal/fisiopatologia
Defecação/efeitos dos fármacos
Fezes/microbiologia
Trato Gastrointestinal/efeitos dos fármacos
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Oligossacarídeos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oligosaccharides); 0 (Plant Extracts); 0 (Prebiotics); 25VX64653N (stachyose)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131120
[St] Status:MEDLINE
[do] DOI:10.1021/jf404160e


  9 / 31 MEDLINE  
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[PMID]:23875903
[Au] Autor:Cui HZ; Oh HC; Li X; Lee YJ; Cho KW; Kang DG; Lee HS
[Ad] Endereço:Professional Graduate School of Oriental Medicine and College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, Korea.
[Ti] Título:Ethanol extract of Lycopus lucidus elicits positive inotropic effect via activation of Ca2+ entry and Ca2+ release in beating rabbit atria.
[So] Source:J Med Food;16(7):633-40, 2013 Jul.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lycopus lucidus Turcz has been widely used as a traditional Oriental medicine (TOM) in Korea and China and prescribed for the enhancement of heart function. However, the precise effects have yet to be defined. The purpose of the present study was, therefore, to address whether the ethanol extract of Lycopus lucidus Turcz (ELT) has a positive inotropic effect. ELT-induced changes in atrial mechanical dynamics (pulse pressure, dp/dt, and stroke volume), and cAMP efflux were measured in perfused beating rabbit atria. Three active components, rosmarinic acid, betulinic acid, and oleanolic acid were identified in ELT by high performance liquid chromatography analysis. ELT increased atrial dynamics in a concentration-dependent manner without changes in atrial cAMP levels and cAMP efflux. The ELT-induced positive inotropic effect was blocked by inhibition of the L-type Ca(2+) channels and sarcoplasmic reticulum (SR). Inhibitors of ß-adrenoceptors had no effect on the ELT-induced positive inotropic effect. The results suggest that ELT exerts a positive inotropic effect via activation of Ca(2+) entry through L-type Ca(2+) channel and Ca(2+) release from the SR in beating rabbit atria.
[Mh] Termos MeSH primário: Cálcio/metabolismo
Cardiotônicos/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Átrios do Coração/metabolismo
Lycopus/química
[Mh] Termos MeSH secundário: Animais
Transporte Biológico/efeitos dos fármacos
Canais de Cálcio Tipo L/metabolismo
Cardiotônicos/química
Cardiotônicos/isolamento & purificação
AMP Cíclico/metabolismo
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Átrios do Coração/efeitos dos fármacos
Técnicas In Vitro
Masculino
Coelhos
Volume Sistólico/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Calcium Channels, L-Type); 0 (Cardiotonic Agents); 0 (Drugs, Chinese Herbal); E0399OZS9N (Cyclic AMP); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130724
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2012.2487


  10 / 31 MEDLINE  
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[PMID]:23827664
[Au] Autor:Yao Y; Yang J; Wang D; Zhou F; Cai X; Lu W; Hu C; Gu Z; Qian S; Guan X; Cao P
[Ad] Endereço:Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Traditional Chinese Medicine, Nanjing, 210028, Jiangsu, China.
[Ti] Título:The aqueous extract of Lycopus lucidus Turcz ameliorates streptozotocin-induced diabetic renal damage via inhibiting TGF-ß1 signaling pathway.
[So] Source:Phytomedicine;20(13):1160-7, 2013 Oct 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Renal fibrosis characterized by accumulation of extracellular matrix protein results in chronic renal diseases including diabetic nephropathy. Transforming growth factor ß1 (TGF-ß1) signaling pathway plays a key role in mediating renal fibrosis. Hence, agents that antagonize TGF-ß signaling could be candidate for kidney disease therapy. METHODS: We established renal fibrosis model both in vitro with fibroblast cells treated with rhTGF-ß1 and streptozocin(STZ)-induced diabetic nephropathy rats model in vivo and evaluated the effect of the aqueous extract of Lycopus lucidus Turcz, the blood-circulation-promoting Chinese herb, on diabetic nephropathy and investigated the mechanism of action. RESULTS: We found that Lycopus suppressed rhTGF-ß1-induced Smad2 and ERK1/2 activation, down-regulated the expression of TGF-ßRI, TGF-ßRII, Smad4 and Smad7 in SV40 MES13 cells without inhibiting cell viability. In vivo, lycopus inhibited Smad2 phosphorylation, reduced mRNA level of TGF-ß1, ameliorated expansion of the mesangial area in glomerular tissue and reduced the levels of Scr and BUN of serum and total-SOD (superoxide dismutase) activity in STZ-induced diabetic rats. CONCLUSION: Lycopus is a novel inhibitor of renal fibrosis by blocking TGF-ß signaling pathway and possess a protective effect on renal damage of STZ-induced diabetic nephropathy in rats.
[Mh] Termos MeSH primário: Nefropatias Diabéticas/tratamento farmacológico
Regulação da Expressão Gênica/efeitos dos fármacos
Lycopus/química
Extratos Vegetais/uso terapêutico
Transdução de Sinais/efeitos dos fármacos
Fator de Crescimento Transformador beta1/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ácidos Cafeicos/química
Ácidos Cafeicos/isolamento & purificação
Linhagem Celular
Cinamatos/química
Cinamatos/isolamento & purificação
Depsídeos/química
Depsídeos/isolamento & purificação
Nefropatias Diabéticas/induzido quimicamente
Nefropatias Diabéticas/metabolismo
Modelos Animais de Doenças
Fibrose
Glucosídeos/química
Glucosídeos/isolamento & purificação
Seres Humanos
Luteolina/química
Luteolina/isolamento & purificação
Masculino
Camundongos
Fosforilação
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Ratos
Ratos Sprague-Dawley
Estreptozocina/farmacologia
Fator de Crescimento Transformador beta1/genética
Fator de Crescimento Transformador beta1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Caffeic Acids); 0 (Cinnamates); 0 (Depsides); 0 (Glucosides); 0 (Plant Extracts); 0 (Transforming Growth Factor beta1); 5W494URQ81 (Streptozocin); 98J6XDS46I (luteolin-7-glucoside); KUX1ZNC9J2 (Luteolin); MQE6XG29YI (rosmarinic acid); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130706
[St] Status:MEDLINE



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