Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.520.465 [Categoria DeCS]
Referências encontradas : 58 [refinar]
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[PMID]:28298169
[Au] Autor:Mittal V; Nanda A
[Ad] Endereço:a Department of Pharmaceutical Sciences , Maharshi Dayanand University , Rohtak , India.
[Ti] Título:Intensification of marrubiin concentration by optimization of microwave-assisted (low CO yielding) extraction process for Marrubium vulgare using central composite design and antioxidant evaluation.
[So] Source:Pharm Biol;55(1):1337-1347, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Marrubium vulgare Linn (Lamiaceae) was generally extracted by conventional methods with low yield of marrubiin; these processes were not considered environment friendly. OBJECTIVE: This study extracts the whole plant of M. vulgare by microwave assisted extraction (MAE) and optimizes the effect of various extraction parameters on the marrubiin yield by using Central Composite Design (CCD). MATERIALS AND METHODS: The selected medicinal plant was extracted using ethanol: water (1:1) as solvent by MAE. The plant material was also extracted using a Soxhlet and the various extracts were analyzed by HPTLC to quantify the marrubiin concentration. RESULTS: The optimized conditions for the microwave-assisted extraction of selected medicinal plant was microwave power of 539 W, irradiation time of 373 s and solvent to drug ratio, 32 mL per g of the drug. The marrubiin concentration in MAE almost doubled relative to the traditional method (0.69 ± 0.08 to 1.35 ± 0.04%). The IC for DPPH was reduced to 66.28 ± 0.6 µg/mL as compared to conventional extract (84.14 ± 0.7 µg/mL). The scanning electron micrographs of the treated and untreated drug samples further support the results. DISCUSSION AND CONCLUSION: The CCD can be successfully applied to optimize the extraction parameters (MAE) for M. vulgare. Moreover, in terms of environmental impact, the MAE technique could be assumed as a 'Green approach' because the MAE approach for extraction of plant released only 92.3 g of CO as compared to 3207.6 g CO using the Soxhlet method of extraction.
[Mh] Termos MeSH primário: Antioxidantes/isolamento & purificação
Dióxido de Carbono
Diterpenos/isolamento & purificação
Marrubium
Micro-Ondas
Extratos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: Antioxidantes/química
Diterpenos/química
Avaliação Pré-Clínica de Medicamentos/métodos
Componentes Aéreos da Planta
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Diterpenes); 0 (Plant Extracts); 142M471B3J (Carbon Dioxide); AP086P88M4 (marrubiin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1297837


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[PMID]:27755961
[Au] Autor:Paunovic V; Kosic M; Djordjevic S; Zugic A; Djalinac N; Gasic U; Trajkovic V; Harhaji-Trajkovic J
[Ad] Endereço:University of Belgrade Institute of Microbiology and Immunology, School of Medicine Belgrade Serbia vericapaunovic@gmail.com.
[Ti] Título:Marrubium vulgare ethanolic extract induces proliferation block, apoptosis, and cytoprotective autophagy in cancer cells in vitro.
[So] Source:Cell Mol Biol (Noisy-le-grand);62(11):108-114, 2016 Sep 30.
[Is] ISSN:1165-158X
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Marrubium vulgare is a European medicinal plant with numerous beneficial effects on human health. The aim of the study was to isolate the plant ethanolic extract (MVE) and to investigate its anti-melanoma and anti-glioma effects. MVE was prepared by the modified pharmacopoeial percolation method and characterized by UHPLC-LTQ OrbiTrap MS. MVE dose-dependently reduced viability of melanoma (B16) and glioma (U251) cells, but not peripheral blood mononuclear cells. It arrested cell cycle in S+G2/M phase, which was associated with the activation of MAP kinase p38 and up-regulation of antiproliferative genes p53, p21 and p27. MVE induced oxidative stress, while antioxidants abrogated its antitumor effect. Furthermore, MVE induced mitochondrial depolarization, activation of caspase-9 and -3, Parp cleavage, phosphatidylserine exposure and DNA fragmentation. The mitochondrial apoptotic pathway was associated with the up-regulation of proapoptotic genes Pten, Bak1, Apaf1, and Puma and down-regulation of antiapoptotic genes survivin and Xiap. MVE also stimulated the expression of autophagy-related genes Atg5, Atg7, Atg12, Beclin-1, Gabarab and Sqstm1, as well as LC3-I conversion to the autophagosome associated LC3-II, while autophagy inhibitors exacerbated its cytotoxicity. Finally, the most abundant phenolic components of MVE, ferulic, p-hydroxybenzoic, caffeic and chlorogenic acids, did not exert a profound effect on viability of tumor cells, suggesting that other components individually or in concert are the mediators of the extracts' cytotoxicity. By demonstrating the ability of MVE to inhibit proliferation, induce apoptosis and cytoprotective autophagy, our results suggest that MVE, alone or combined with autophagy inhibitors, could be a good candidate for anti-melanoma and anti-glioma therapy.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Marrubium/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Proteínas Reguladoras de Apoptose/genética
Proteínas Reguladoras de Apoptose/metabolismo
Caspases/metabolismo
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Regulação para Baixo/efeitos dos fármacos
Etanol/química
Seres Humanos
Marrubium/metabolismo
Camundongos
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Fenol/química
Fenol/toxicidade
Componentes Aéreos da Planta/química
Componentes Aéreos da Planta/metabolismo
Extratos Vegetais/química
Espécies Reativas de Oxigênio/metabolismo
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Apoptosis Regulatory Proteins); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 339NCG44TV (Phenol); 3K9958V90M (Ethanol); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27735121
[Au] Autor:Mafu S; Fischer E; Addison JB; Riberio Barbosana I; Zerbe P
[Ad] Endereço:Department of Plant Biology, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA.
[Ti] Título:Substitution of Two Active-Site Residues Alters C9-Hydroxylation in a Class II Diterpene Synthase.
[So] Source:Chembiochem;17(24):2304-2307, 2016 Dec 14.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Diterpenes form a vast and diverse class of natural products of both ecological and economic importance. Class II diterpene synthase (diTPS) enzymes control the committed biosynthetic reactions underlying diterpene chemical diversity. Homology modelling with site-directed mutagenesis identified two active-site residues in the horehound (Marrubium vulgare) class II diTPS peregrinol diphosphate synthase (MvCPS1); residue substitutions abolished the unique MvCPS1-catalysed water-capture reaction at C9 and redirected enzyme activity toward formation of an alternative product, halima-5(10),13-dienyl diphosphate. These findings contributed new insight into the steric interactions that govern diTPS-catalysed regiospecific oxygenation reactions and highlight the feasibility of diTPS engineering to provide a broader spectrum of bioactive diterpene natural products.
[Mh] Termos MeSH primário: Alquil e Aril Transferases/metabolismo
Proteínas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Alquil e Aril Transferases/genética
Sequência de Aminoácidos
Biocatálise
Domínio Catalítico
Diterpenos/química
Cromatografia Gasosa-Espectrometria de Massas
Hidroxilação
Espectroscopia de Ressonância Magnética
Marrubium/enzimologia
Dados de Sequência Molecular
Mutagênese Sítio-Dirigida
Proteínas de Plantas/genética
Alinhamento de Sequência
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (Plant Proteins); EC 2.5.- (Alkyl and Aryl Transferases); EC 2.5.1.- (terpene synthase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201600419


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[PMID]:27553439
[Au] Autor:Bouterfas K; Mehdadi Z; Elaoufi MM; Latreche A; Benchiha W
[Ad] Endereço:Laboratory of vegetal biodiversity: conservation and valorization, faculty of life and natural sciences, Djillali Liabes university, 22000 Sidi Bel-Abbes, Algeria. Electronic address: bouterfas_karim@yahoo.fr.
[Ti] Título:Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linné) from three geographical origins.
[So] Source:Ann Pharm Fr;74(6):453-462, 2016 Nov.
[Is] ISSN:0003-4509
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:OBJECTIFS: To elucidate the effect of the sampling location of Marrubium vulgare L. leaves on phenolic contents and antioxidant proprieties of flavonoids extracts. MATERIALS AND METHODS: M. vulgare L. leaves were collected from three different geographical locations belonging to northwest Algeria: Tessala (mountain region), M'sila forest (coastal region), and Ain Skhouna (steppe region). The flavonoid extraction was achieved using organic solvents with different polarities (methanol, chloroform, ethyl acetate, and hexane). Folin-Ciocalteu colorimetric method was used for quantification of total phenolic contents, and aluminum chloride assay for quantification of total flavonoid contents. The antioxidant properties of flavonoids extract were studied by free l,l-diphenyl-2-picrylhydrazyl radical-scavenging technique. RESULTS: Total phenolic and flavonoids concentrations varied respectively between 40.7 and 160mg gallic acid equivalents/g and 27.4 and 66.3mg catechin equivalents/g. The DPPH free radical-scavenging activity shows that the antioxidant activity of the flavonoid extracts varied significantly (P<0.001) depending on the type of the organic solvent used, and the sampling location. The methanol, chloroform and ethyl acetate extracts exhibited the highest percentages of inhibition unlike to the aqueous and hexane extracts. These percentages are ranged from 54.8 to 98.8% at 1000µg/mL. In general, M'sila forest flavonoids extracts showed the highest free radical inhibition capacity; followed by those of Ain Skhouna and Tessala Mountain. The inhibitory concentration 50 (IC ) ranged from 33.7 to 774µg/mL and often exceeded those recorded by phenolic standards (ascorbic acid, gallic acid, caffeic acid, tannic acid and catechin). The phytochemical screening revealed the presence of some flavonoid classes, such as flavans and flavanols. CONCLUSION: The results suggested a potent antioxidant activity of M. vulgare flavonoids extracts, which may find its application in feature research for the food and the pharmacological industries.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Flavonoides/química
Flavonoides/farmacologia
Marrubium/química
Fenóis/química
Fenóis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Argélia
Compostos de Bifenilo/química
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/farmacologia
Geografia
Picratos/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE


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[PMID]:27278070
[Au] Autor:Güleryüz G; Erdemir ÜS; Arslan H; Güçer S
[Ad] Endereço:Faculty of Arts and Sciences, Department of Biology, Uludag University, 16059, Bursa, Turkey. gurcan@uludag.edu.tr.
[Ti] Título:Elemental composition of Marrubium astracanicum Jacq. growing in tungsten-contaminated sites.
[So] Source:Environ Sci Pollut Res Int;23(18):18332-42, 2016 Sep.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study evaluates the elemental (W, Mo, Zn, Fe, Cu, Cd, Mn, Pb, Cr, Co, B, and Bi) composition of Marrubium astracanicum Jacq. (Lamiaceae), around the abandoned tungsten mine on Uludag Mountain, Turkey, to determine if it is an appropriate candidate for phytomonitoring and/or phytoremediation purposes. Three sample sites were selected around the mine for soil and plant sampling. Two sites approximately 500 m from the mine were assumed to be unpolluted sites. The other site was selected from a waste removal pool (WRP) and was assumed to be a polluted site. The soil and different organs (roots, leaves, and flowers) of plant samples were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) to determine the elemental content. The classic open wet digestion procedure was applied to the samples with 5 mL HNO3 and 3 mL H2O2 in a borosilicate glass vessel for the roots, leaves, and the flowers of the plants. Kjeldahl digestion was used for the soil samples. The W, Zn, Fe, Cu, Cd, Mn, Pb, B, and Bi contents were found to be higher in the soil samples from the waste removal pools compared with the samples from the unpolluted sites. We also found that the elemental composition of M. astracanicum has generally been increased by the activity of the tungsten mine, and there were significant correlations between the elemental contents of the soil samples and plant parts, except for Mo and Cr. The high level of many elements in the soil samples indicates the presence of contamination related to tungsten-mining activity on Uludag Mountain. Assessing the elemental contents of M. astracanicum, we can suggest this species as a candidate for phytoremediation purposes of W-contaminated sites due to its high W-accumulation capacity.
[Mh] Termos MeSH primário: Marrubium/efeitos dos fármacos
Marrubium/crescimento & desenvolvimento
Tungstênio/farmacologia
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Peróxido de Hidrogênio/farmacologia
Mineração
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/crescimento & desenvolvimento
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/crescimento & desenvolvimento
Solo/química
Poluentes do Solo/análise
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); BBX060AN9V (Hydrogen Peroxide); V9306CXO6G (Tungsten)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7028-z


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[PMID]:27271209
[Au] Autor:Rodríguez Villanueva J; Martín Esteban J
[Ad] Endereço:Departamento de Ciencias Biomédicas, Facultad de Farmacia, Universidad de Alcalá, Ctra. Madrid-Barcelona (Autovía A-II), Km. 33.600, 28805, Alcalá de Henares, Spain. javier.rodriguezv@edu.uah.es.
[Ti] Título:An Insight into a Blockbuster Phytomedicine; Marrubium vulgare L. Herb. More of a Myth than a Reality?
[So] Source:Phytother Res;30(10):1551-1558, 2016 Oct.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aerial parts and the root of Marrubium vulgare L. (white horehound) have been traditionally used in Europe and in southern and eastern Mediterranean countries. During colonization, the plant was introduced in America to great levels of popularity because of the simplicity of its growing; it was especially popular in Mexico and Brazil, where it has been known as 'maromba', 'marroio' or 'marroio-branco'. Ethnopharmacological uses of M. vulgare include treating respiratory diseases such as acute or chronic bronchitis, colds and asthma. The plant is also used in cases where there is a lack of appetite or dyspepsia and for diagnosed type II diabetes. It has even been used for antihypertensive therapy. For decades, scientists have carried out extensive research trying to explain these and other pharmacologic actions. It is time to systematize and critically analyse the quality of results found to date. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Marrubium/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5661


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[PMID]:26994761
[Au] Autor:Bouterfas K; Mehdadi Z; Aouad L; Elaoufi MM; Khaled MB; Latreche A; Benchiha W
[Ad] Endereço:Laboratoire de biodiversité végétale : conservation et valorisation, faculté des sciences de la nature et de la vie, université Djillali Liabes, BP 89, Haï Larbi Ben M'hidi, 22000 Sidi Bel-Abbés, Algérie; Département de l'environnement, faculté des sciences de la nature et de la vie, université Djil
[Ti] Título:[Does the sampling locality influence on the antifungal activity of the flavonoids of Marrubium vulgare against Aspergillus niger and Candida albicans?].
[Ti] Título:La localité d'échantillonnage influence-t-elle l'activité antifongique des flavonoïdes de Marrubium vulgare vis-à-vis de Aspergillus niger et Candida albicans ?.
[So] Source:J Mycol Med;26(3):201-11, 2016 Sep.
[Is] ISSN:1773-0449
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:OBJECTIVE: The study was undertaken to determine the effect of the sampling locality on the antifungal activity of the flavonoids extracted from the leaves of Marrubium vulgare L. against two fungal strains; Aspergillus niger ATCC 16404 and Candida albicans ATCC 10231. MATERIALS AND METHODS: The leaves were collected from three different sampling localities belonging northwest Algeria: Tessala mount, M'sila forest and Ain Skhouna. The flavonoid extraction was carried out by using organic solvents with increasing polarity. A phytochemical screening was performed by staining test tubes. The inhibition diameters were measured by solid medium diffusion method. The minimum inhibitory concentrations were determined by dilution method on solid medium. RESULTS: The antifungal activity varied significantly (P<0.001) according to the sampling locality of the leaves, the flavonoid extract and its concentration, and the strain fungal type. The inhibition diameters varied between 8.16 and recorded 37.5mm even recording a total inhibition of fungal growth and often exceed those induced marketed antifungals (Amphotericin, Fluconazole, Terbinafine and econazole nitrate). The minimum inhibitory concentrations (MICs) obtained range between 6.25 and 100µg/mL; experiencing strong antifungal inhibition. The phytochemical screening revealed the existence of certain flavonoids classes such as flavans and flavanols which may be responsible of this remarkable antifungal power. CONCLUSION: The sampling locality of Marrubium vulgare leaves influenced on the antifungal activity of flavonoids. These have proven very good fungistatic and worth valuing in pharmacology.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Flavonoides/análise
Marrubium/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Aspergillus niger/efeitos dos fármacos
Aspergillus niger/crescimento & desenvolvimento
Candida albicans/efeitos dos fármacos
Candida albicans/crescimento & desenvolvimento
Relação Dose-Resposta a Droga
Flavonoides/farmacologia
Geografia
Seres Humanos
Testes de Sensibilidade Microbiana
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Flavonoids); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160321
[St] Status:MEDLINE


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[PMID]:26927415
[Au] Autor:Hammami S; Li Z; Huang M; El Mokni R; Dhaouadi H; Yin S
[Ad] Endereço:a Research Unit Applied Chemistry and Environment 13ES63, Faculty of Sciences of Monastir , Monastir University , Monastir , Tunisia.
[Ti] Título:New bioactive labdane diterpenoids from Marrubium aschersonii.
[So] Source:Nat Prod Res;30(19):2142-8, 2016 Oct.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation of the ethanol extract of Marrubium aschersonii Magnus (Lamiaceae) collected from Tunisia led to the isolation and identification of two new labdane diterpenoids, marrubaschs A (1) and B (2), along with two known compounds (3 and 4). Their structures were elucidated by spectroscopic methods including HRESIMS and NMR techniques. All compounds were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide in RAW 264.7 macrophage cells. Compound 2 exhibited weak inhibition of NO production with an IC50 value of 35 ± 1.0 µM.
[Mh] Termos MeSH primário: Diterpenos/isolamento & purificação
Diterpenos/farmacologia
Marrubium/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Diterpenos/química
Avaliação Pré-Clínica de Medicamentos/métodos
Furanos/isolamento & purificação
Furanos/farmacologia
Concentração Inibidora 50
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Espectroscopia de Ressonância Magnética
Camundongos
Estrutura Molecular
Óxido Nítrico/biossíntese
Extratos Vegetais/química
Tunísia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (Furans); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (marrubasch B); 0 (marrubenol); 31C4KY9ESH (Nitric Oxide); AP086P88M4 (marrubiin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1143828


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[PMID]:26886858
[Au] Autor:Ettaya A; Dhibi S; Samout N; Elfeki A; Hfaiedh N
[Ad] Endereço:a Laboratory of Environmental Physiopathology, Valorization of Bioactive Molecules and Mathematical Modeling, Faculty of Sciences of Sfax, Road Soukra km 3.5- PB n° 1171-3000, Sfax, Tunisia.
[Ti] Título:Hepatoprotective activity of white horehound (Marrubium vulgare) extract against cyclophosphamide toxicity in male rats.
[So] Source:Can J Physiol Pharmacol;94(4):441-7, 2016 Apr.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:The hepatoprotective activity of Marrubium vulgare against cyclophosphamide toxicity in Wistar rats was evaluated. Adult male rats were divided into 4 groups of 6 each: a control group, a group injected with cyclophosphamide (150 mg·kg(-1)) for 3 days, a group orally given a M. vulgare aqueous extract ((500 mg of dry leaves)·kg(-1)·day(-1)) for 30 days then treated with cyclophosphamide, and a group receiving only M. vulgare for 30 days. After 33 days of treatment, activities of alanine amino transferase (ALAT), aspartate amino transferase (ASAT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) were determined in serum. Moreover, lipid peroxidation level and superoxide dismutase (SOD) activities, catalase (CAT) and glutathione peroxidase (GPx) were measured in liver. Alterations of these hepatic biomarkers and increased lipid peroxidation confirmed cyclophosphamide-induced liver toxicity. Cyclophosphamide also decreased the enzymatic defense system against oxidative stress. However, when this drug was administered in rats given M. vulgare extract, all the biological parameters underwent much less alteration. Administration of M. vulgare extract was found to be beneficial by attenuating cyclophosphamide-induced liver damage. The protective effect of the plant is mainly attributed to its antioxidant properties and the existence of phenolic acids and flavonoids, as highlighted by HPLC-based analysis.
[Mh] Termos MeSH primário: Ciclofosfamida/efeitos adversos
Fígado/efeitos dos fármacos
Marrubium/química
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Antioxidantes/metabolismo
Aspartato Aminotransferases/sangue
Tetracloreto de Carbono/farmacologia
Catalase/metabolismo
Flavonoides/farmacologia
Glutationa Peroxidase/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/metabolismo
Masculino
Estresse Oxidativo/efeitos dos fármacos
Folhas de Planta/química
Ratos
Ratos Wistar
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Protective Agents); 0 (horehound leaf extract); 8N3DW7272P (Cyclophosphamide); CL2T97X0V0 (Carbon Tetrachloride); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE
[do] DOI:10.1139/cjpp-2015-0405


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[PMID]:26314352
[Au] Autor:Habibi G; Ajory N
[Ad] Endereço:Department of Biology, Payame Noor University, PO BOX 19395-3697, Tehran, Iran. gader.habibi@gmail.com.
[Ti] Título:The effect of drought on photosynthetic plasticity in Marrubium vulgare plants growing at low and high altitudes.
[So] Source:J Plant Res;128(6):987-94, 2015 Nov.
[Is] ISSN:1618-0860
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Photosynthesis is a biological process most affected by water deficit. Plants have various photosynthetic mechanisms that are matched to specific climatic zones. We studied the photosynthetic plasticity of C3 plants at water deficit using ecotypes of Marrubium vulgare L. from high (2,200 m) and low (1,100 m) elevation sites in the Mishou-Dagh Mountains of Iran. Under experimental drought, high-altitude plants showed more tolerance to water stress based on most of the parameters studied as compared to the low-altitude plants. Increased tolerance in high-altitude plants was achieved by lower levels of daytime stomatal conductance (g s) and reduced damaging effect on maximal quantum yield of photosystem II (PSII) (F v /F m ) coupled with higher levels of carotenoids and non-photochemical quenching (NPQ). High-altitude plants exhibited higher water use efficiency (WUE) than that in low-altitude plants depending on the presence of thick leaves and the reduced daytime stomatal conductance. Additionally, we have studied the oscillation in H(+) content and diel gas exchange patterns to determine the occurrence of C3 or weak CAM (Crassulacean acid metabolism) in M. vulgare through 15 days drought stress. Under water-stressed conditions, low-altitude plants exhibited stomatal conductance and acid fluctuations characteristic of C3 photosynthesis, though high-altitude plants exhibited more pronounced increases in nocturnal acidity and phosphoenolpyruvate carboxylase (PEPC) activity, suggesting photosynthetic flexibility. These results indicated that the regulation of carotenoids, NPQ, stomatal conductance and diel patterns of CO2 exchange presented the larger differences among studied plants at different altitudes and seem to be the protecting mechanisms controlling the photosynthetic performance of M. vulgare plants under drought conditions.
[Mh] Termos MeSH primário: Altitude
Secas
Marrubium/fisiologia
Fotossíntese
[Mh] Termos MeSH secundário: Irã (Geográfico)
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150829
[St] Status:MEDLINE
[do] DOI:10.1007/s10265-015-0748-1



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