Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.520.474 [Categoria DeCS]
Referências encontradas : 166 [refinar]
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[PMID]:28946270
[Au] Autor:Pereira E; Antonio A; Barreira JCM; Santos-Buelga C; Barros L; Ferreira ICFR
[Ad] Endereço:Centrode Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal; GIP-USAL, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
[Ti] Título:How gamma and electron-beam irradiations modulate phenolic profile expression in Melissa officinalis L. and Melittis melissophyllum L.
[So] Source:Food Chem;240:253-258, 2018 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Owing to the overall increase in herbal infusions' consumption, there's a progressively higher need of suitable plant material, as well as adequate conservation techniques to maintain its quality. Among, the available technologies, irradiation is gaining interest as a feasible preservation method. In line with this approach, this wok was designed to evaluate the effects of electron-beam and gamma irradiation over the phenolic profiles of two plant species Melissa officinalis L. (LB) and Melittis melissophyllum L. (BB). Individual phenolics were characterized by high-performance liquid chromatography coupled to a diode array detector and a mass spectrometer (HPLC-DAD-ESI/MS). Irradiated samples showed a general increase in individual phenolic contents, especially in lithospermic acid A in LB and 5-O-caffeoylquinic acid in BB. Thus, this study revealed the potential usefulness of both conservation technologies when employed to this type of plants.
[Mh] Termos MeSH primário: Lamiaceae
Melissa
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Elétrons
Fenóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE


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[PMID]:28573351
[Au] Autor:Dwivedi S; Kumar M; Trivedi SP
[Ad] Endereço:Environmental Toxicology and Bioremediation Laboratory, Department of Zoology, University of Lucknow, Lucknow, 226007, India.
[Ti] Título:Mitigating potential of Melissa officinale against As -induced cytotoxicity and transcriptional alterations of Hsp70 and Hsp27 in fish, Channa punctatus (Bloch).
[So] Source:Environ Monit Assess;189(7):306, 2017 Jul.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The mitigating potential of Melissa officinale (MO) (Lamiaceae) against arsenite (As )-induced oxidative stress, cytogenotoxicity, and expression of stress genes in fish, Channa punctatus (Bloch), teleost, was explored. After confirming the composition of MO extract, caffeic acid (0.96%), hesperidin (1.73%), naringenin (7.70%), lutenolin (3.29%), kaempferol (11.46%) and hesperetin (6.24%), by HPLC-PDA analysis, the experiment was set up in six groups (G1-G6), each containing 10 specimens. Blood, muscle, gills and liver tissues of control and treated fishes were excised at an interval of 24 till 96 h. Ameliorative potential of MO was confirmed by satisfactory restoration of altered activities of malondialdehyde, hydrogen peroxide, superoxide dismutase, catalase, glutathione peroxidise, glutathione reductase, reduced glutathione and ascorbate peroxidase in G4, G5 and G6, co-exposed with 96 h-LC /10 As with MO. A significant (p < 0.05) recovery in the frequencies of cytogenotoxic markers, micronuclei, disintegrated nucleus and echinocytes, which were expressed significantly (p < 0.05) in G3 exposed to sub-lethal concentration of ATO alone, was recorded in fish groups (G4, G5 and G6) together treated with 96 h-LC /10 of ATO and 2, 4 and 8 ppm of MO, respectively. Moreover, the expression of Hsp70 gene was downregulated (2.29-fold); whereas, Hsp27 gene was upregulated (1.16-fold) in G6, the group co-exposed with 96 h-LC /10 As with 8 ppm of MO in comparison with G3 (3.11-fold for Hsp70; 0.51-fold for Hsp27) after 96 h of exposure period. Thus, it can be inferred that the MO at its tested concentration can be effectively used to mitigate As generated toxicities in C. punctatus.
[Mh] Termos MeSH primário: Arsênico/toxicidade
Proteínas de Choque Térmico HSP27/genética
Proteínas de Choque Térmico HSP70/genética
Perciformes/fisiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Arsênico/metabolismo
Biomarcadores/metabolismo
Catalase/metabolismo
Monitoramento Ambiental
Peixes/metabolismo
Brânquias/metabolismo
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Glutationa Redutase/metabolismo
Glutationa Transferase/metabolismo
Proteínas de Choque Térmico HSP27/metabolismo
Proteínas de Choque Térmico HSP70/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/metabolismo
Malondialdeído/metabolismo
Melissa
Estresse Oxidativo/efeitos dos fármacos
Perciformes/metabolismo
Superóxido Dismutase/metabolismo
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (HSP27 Heat-Shock Proteins); 0 (HSP70 Heat-Shock Proteins); 0 (Water Pollutants, Chemical); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 1.8.1.7 (Glutathione Reductase); EC 2.5.1.18 (Glutathione Transferase); GAN16C9B8O (Glutathione); N712M78A8G (Arsenic)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6002-7


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[PMID]:28571771
[Au] Autor:Kim J; Lee H; Lim J; Lee H; Yoon S; Shin SS; Yoon M
[Ad] Endereço:Department of Biomedical Engineering, Mokwon University, Daejeon, 302-729, South Korea.
[Ti] Título:The lemon balm extract ALS-L1023 inhibits obesity and nonalcoholic fatty liver disease in female ovariectomized mice.
[So] Source:Food Chem Toxicol;106(Pt A):292-305, 2017 Aug.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Increasing evidence indicates that angiogenesis inhibitors regulate obesity. This study aimed to determine whether the lemon balm extract ALS-L1023 inhibits diet-induced obesity and nonalcoholic fatty liver disease (NAFLD) in female ovariectomized (OVX) mice. OVX mice received a low fat diet (LFD), a high fat diet (HFD) or HFD supplemented with ALS-L1023 (ALS-L1023) for 15 weeks. HFD mice exhibited increases in visceral adipose tissue (VAT) angiogenesis, body weight, VAT mass and VAT inflammation compared with LFD mice. In contrast, all of these effects were reduced in ALS-L1023 mice compared with HFD mice. Serum lipids and liver injury markers were improved in ALS-L1023 mice. Hepatic lipid accumulation, inflammatory cells and collagen levels were lower in ALS-L1023 mice than in HFD mice. ALS-L1023 mice exhibited a tendency to normalize hepatic expression of genes involved in lipid metabolism, inflammation and fibrosis to levels in LFD mice. ALS-L1023 also induced Akt phosphorylation and increased Nrf2 mRNA expression in livers of obese mice. Our results indicate that the angiogenesis inhibitor ALS-L1023 can regulate obesity, hepatic steatosis and fibro-inflammation, in part through improvement of VAT function, in obese OVX mice. These findings suggest that angiogenesis inhibitors may contribute to alleviation of NAFLD in post-menopausal women with obesity.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/administração & dosagem
Melissa/química
Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico
Obesidade/tratamento farmacológico
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Tecido Adiposo/metabolismo
Animais
Feminino
Metabolismo dos Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Obesos
Hepatopatia Gordurosa não Alcoólica/metabolismo
Obesidade/metabolismo
Ovariectomia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ALS-L1023); 0 (Angiogenesis Inhibitors); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


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[PMID]:28420164
[Au] Autor:Kim J; Lee H; Lim J; Oh J; Shin SS; Yoon M
[Ad] Endereço:Department of Biomedical Engineering, Mokwon University, Daejeon 35349, Korea. sdsd2586@naver.com.
[Ti] Título:The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease through Regulating the Visceral Adipose-Tissue Function.
[So] Source:Int J Mol Sci;18(4), 2017 Apr 17.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Similar to neoplastic tissues, growth and development of adipose tissue are thought to be angiogenesis-dependent. Since visceral adipose tissue (VAT) is associated with development and progression of nonalcoholic fatty liver disease (NAFLD), we hypothesized that angiogenesis inhibition would attenuate obesity-induced NAFLD. We fed C57BL/6J mice a low-fat diet (LFD, chow 10% kcal fat), a high-fat diet (HFD, 45% kcal fat) or HFD supplemented with the lemon-balm extract ALS-L1023 (HFD-ALS) for 15 weeks. ALS-L1023 reduced endothelial cell-tube formation in vitro. HFD increased VAT angiogenesis and induced weight gains including body weight, VAT mass and visceral adipocyte size compared with LFD. However, HFD-ALS led to weight reductions without affecting calorie intake compared with HFD. HFD-ALS also reduced serum ALT and AST levels and improved lipid metabolism. HFD-ALS suppressed steatosis, infiltration of inflammatory cells, and accumulation of collagen in livers. HFD-ALS modulated hepatic expression of genes involved in lipid metabolism, inflammation, fibrosis, antioxidation, and apoptosis. Concomitantly, analysis of VAT function revealed that HFD-ALS led to fewer CD68-positive macrophage numbers and lower expression of inflammatory cytokines compared with HFD. Our findings show that the anti-angiogenic herbal extract ALS-L1023 attenuates NAFLD by targeting VAT during obesity, suggesting that angiogenesis inhibitors could aid in the treatment and prevention of obesity-induced human NAFLD.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Dieta Hiperlipídica/efeitos adversos
Gordura Intra-Abdominal/efeitos dos fármacos
Gordura Intra-Abdominal/metabolismo
Hepatopatia Gordurosa não Alcoólica/etiologia
Hepatopatia Gordurosa não Alcoólica/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Adipócitos/efeitos dos fármacos
Adipócitos/metabolismo
Animais
Biomarcadores
Modelos Animais de Doenças
Regulação da Expressão Gênica/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/metabolismo
Seres Humanos
Metabolismo dos Lipídeos/efeitos dos fármacos
Lipídeos/sangue
Masculino
Melissa/química
Camundongos
Neovascularização Fisiológica/efeitos dos fármacos
Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico
Hepatopatia Gordurosa não Alcoólica/patologia
Tamanho do Órgão/efeitos dos fármacos
Extratos Vegetais/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ALS-L1023); 0 (Angiogenesis Inhibitors); 0 (Biomarkers); 0 (Lipids); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


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[PMID]:28369977
[Au] Autor:Özogul F; Öztekin R; Kulawik P
[Ad] Endereço:Dept. of Seafood Processing Technology, Faculty of Fisheries, Cukurova Univ., 01330, Adana, Turkey.
[Ti] Título:Biogenic Amine Formation and Microbiological Quality of Anchovy (Engraulis encrasicolus) Treated with Lavender and Lemon Balm Ethanol Extracts.
[So] Source:J Food Sci;82(5):1278-1284, 2017 May.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biogenic amine formation and bacterial growth of vacuum-packed European anchovy treated with 1% lemon balm (LB) or lavender (LD) ethanol extracts was investigated. The treated samples were stored at 2 ± 1 °C for 11 d and analyzed for biogenic amines, total viable count, fecal coliform count, and lactic acid bacterial count. The analyses were done on 0, 4, 7, 9, and 11 d of storage. Both LB and LD extracts proved effective in reducing most biogenic amines, with histamine reduced by 3-fold compared to control. The calculated biogenic amine index showed that LB extract was the most effective in inhibiting the biogenic amine formation. The reduction in total viable count was low and the bacterial contamination reached more than 7 log cfu/g at the end of the storage period for all the samples. Moreover, the reduction in fecal coliform and lactic acid bacterial count by LB and LD extracts was below 1 log cfu/g. Treatment of European anchovy with LB and LD extracts proved to be a very effective preservation technique to reduce the biogenic amine formation and lower the risk of histamine fish poisoning but is not effective in reduction of bacterial load. Consequently, LB and LD extracts could be used to reduce the biogenic amine formation which provides additional safety prior to spoilage for histamine sensitive fish species.
[Mh] Termos MeSH primário: Aminas Biogênicas/química
Microbiologia de Alimentos
Lavandula/química
Carne/microbiologia
Melissa/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Etanol/análise
Peixes/microbiologia
Histamina/análise
Extratos Vegetais/química
Vácuo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biogenic Amines); 0 (Plant Extracts); 3K9958V90M (Ethanol); 820484N8I3 (Histamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13704


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[PMID]:28367927
[Au] Autor:Yui S; Fujiwara S; Harada K; Motoike-Hamura M; Sakai M; Matsubara S; Miyazaki K
[Ad] Endereço:Yakult Central Institute.
[Ti] Título:Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults.
[So] Source:J Nutr Sci Vitaminol (Tokyo);63(1):59-68, 2017.
[Is] ISSN:1881-7742
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Glycation, a non-enzymatic glycosylation of proteins, induces tissue damage in association with various diseases and aging phenomena. Pentosidine, an advanced glycation end product, is involved in aging phenomena such as tissue stiffness. In this study, we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial. From among 681 hot water plant extracts, lemon balm (Melissa officinalis; LB) leaf extract was selected and revealed to have more potent inhibitory activity for pentosidine formation than a representative anti-glycation agent, aminoguanidine. Rosmarinic acid (RA), a typical polyphenol in Lamiaceae plants, was identified as a major active component in LB extract (LBE). Furthermore, LBE or RA dose-dependently suppressed glycation-associated reactions such as increased fluorescence, yellowing of collagen fiber sheets, and degeneration of the fibrous structure of elastin fiber sheets. An open-label, parallel-group comparative trial was conducted in 28 healthy Japanese subjects aged 31-65 y who consumed LB tea (LB group) or barley tea (Control group) for 6 wk. The LB group showed significant reductions in brachial-ankle pulse wave velocity, reflecting arterial stiffness, and b* (yellow) color values in forearm skin compared with the Control group. A gender-stratified analysis revealed that cheek skin elasticity was significantly improved in the LB group compared with the Control group only in female subjects. It is concluded that the hot water extract of LB leaf has the potential to provide health benefits with regard to glycation-associated tissue damage in blood vessels and skin of healthy adults.
[Mh] Termos MeSH primário: Glicosilação/efeitos dos fármacos
Melissa/química
Extratos Vegetais/farmacologia
Fenômenos Fisiológicos da Pele/efeitos dos fármacos
Rigidez Vascular/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Proteínas de Arabidopsis/química
Bebidas
Cinamatos/farmacologia
Depsídeos/farmacologia
Dieta
Elasticidade
Feminino
Seres Humanos
Japão
Masculino
Meia-Idade
Proteínas Nucleares/química
Fitoterapia
Extratos Vegetais/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (Cinnamates); 0 (Depsides); 0 (LFR protein, Arabidopsis); 0 (Nuclear Proteins); 0 (Plant Extracts); MQE6XG29YI (rosmarinic acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.3177/jnsv.63.59


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[PMID]:28259690
[Au] Autor:Jahanban-Esfahlan R; Seidi K; Monfaredan A; Shafie-Irannejad V; Abbasi MM; Karimian A; Yousefi B
[Ad] Endereço:Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
[Ti] Título:The herbal medicine Melissa officinalis extract effects on gene expression of p53, Bcl-2, Her2, VEGF-A and hTERT in human lung, breast and prostate cancer cell lines.
[So] Source:Gene;613:14-19, 2017 May 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Earlier, we verified that Melissa officinalis extract (MOE) elicits potent antiproliferative effects on different human cancer cells. To gain insights into the molecular mechanisms accounting for the cytotoxic effects of MOE, we assessed the expression patterns of several prominent molecules with therapeutic potential in cancer by Quantitative PCR (Q-PCR). METHODS: A549, MCF-7 and PC3 cancer cells were grown in complete RPMI 1640 and seeded in 24 well micro plates. After incubation for 72h, 100µg/ml of MOE was added and the cells were further incubated for 72h. Afterwards, the cells were subjected to RNA extraction for the means of Q-PCR. RESULTS: Our results indicated that in PC3 cancer cells, MOE resulted in a significant downregulation of VEGF-A (0.0004 fold), Bcl-2 (0.001 fold), Her2 (0.02 fold), and hTERT (0.023 fold) compared to the untreated control. In addition, VEGF-A and hTERT mRNA were significantly downregulated in MCF-7 and A549 cancer cells, as well. Notably, high anti-angiogenic activity was closely associated with a high anti-telomerase activity of MOE in studying cancer cells. The decrease in VEGF-A expression was significantly superior than that of hTERT downregulation, as PC3 cancer cells with the highest hTERT down regulation (0.023) presented the highest anti VEGF activity (0.0004 fold), whereas MCF-7 cells with the lowest hTERT inhibition (0.213) showed the lowest VEGF inhibition(0.0435) among the three studied cancer cells. We noticed that the modulation of VEGF-A and hTERT gene expression can be considered as a common target, accounting for the therapeutic potential of MOE on human breast, lung and prostate cancer cells. CONCLUSION: Altogether, it is suggested that the potent antiproliferative activity of the hydroalcoholic extract of Melissa officinalis is somehow explainable by its high potency to inhibit expression of the prominent oncogenes Bcl2, Her2, VEGF-A and hTERT in prostate cancer. In tumors with functional p53, including MCF-7 and A549 cancer cells, the role of p53, Bcl2 and Her2 is less significant. It appears that MOE exerts its antiproliferative effects in these cancer cells partly via concurrent downregulation of VEGF-A and hTERT. Additional studies are needed to clarify the role of other active molecules in cancer cells harboring functional p53.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Expressão Gênica/efeitos dos fármacos
Melissa/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Seres Humanos
Folhas de Planta/química
Proto-Oncogenes/efeitos dos fármacos
Reação em Cadeia da Polimerase em Tempo Real
Proteína Supressora de Tumor p53/genética
Fator A de Crescimento do Endotélio Vascular/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE


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[PMID]:28101823
[Au] Autor:García-Risco MR; Mouhid L; Salas-Pérez L; López-Padilla A; Santoyo S; Jaime L; Ramírez de Molina A; Reglero G; Fornari T
[Ad] Endereço:Institute of Food Science Research (CIAL), Madrid, Spain.
[Ti] Título:Biological Activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) Plant Extracts.
[So] Source:Plant Foods Hum Nutr;72(1):96-102, 2017 Mar.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) extracts were obtained by applying two sequential extraction processes: supercritical fluid extraction with carbon dioxide, followed by ultrasonic assisted extraction using green solvents (ethanol and ethanol:water 50:50). The extracts were analyzed in terms of the total content of phenolic compounds and the content of flavonoids; the volatile oil composition of supercritical extracts was analyzed by gas chromatography and the antioxidant capacity and cell toxicity was determined. Lamiaceae plant extracts presented higher content of phenolics (and flavonoids) than Asteraceae extracts. Regardless of the species studied, the supercritical extracts presented the lowest antioxidant activity and the ethanol:water extracts offered the largest, following the order Origanum majorana > Melissa officinalis ≈ Achillea millefolium > Calendula officinalis. However, concerning the effect on cell toxicity, Asteraceae (especially Achillea millefolium) supercritical extracts were significantly more efficient despite being the less active as an antioxidant agent. These results indicate that the effect on cell viability is not related to the antioxidant activity of the extracts.
[Mh] Termos MeSH primário: Achillea/química
Antioxidantes/farmacologia
Calendula/química
Melissa/química
Origanum/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/análise
Sobrevivência Celular/efeitos dos fármacos
Cromatografia com Fluido Supercrítico
Flavonoides/análise
Flavonoides/farmacologia
Óleos Voláteis/análise
Óleos Voláteis/farmacologia
Fenóis/análise
Fenóis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Oils, Volatile); 0 (Phenols); 0 (Plant Extracts); 0 (Solvents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-016-0596-8


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[PMID]:27784232
[Au] Autor:Iman M; Araghi M; Heidari T; Mohammadi V
[Ti] Título:Melissa of cinalis and Vitamin E as the Potential Therapeutic Candidates for Reproductive Toxicity Caused by Anti-cancer Drug, Cisplatin, in Male Rats.
[So] Source:Recent Pat Anticancer Drug Discov;12(1):73-80, 2017.
[Is] ISSN:2212-3970
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: High doses of Cisplatin (CP) can disrupt the normal functioning of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia. OBJECTIVE: In this study, the defensive effect of Melissa of cinalis and vitamin E against testicular injuries caused by CP in male rats was evaluated. METHOD: Thirty six male rats were distributed into 6 groups. Group 1 was used as the negative control. In group 2, a single dose of CP (10 mg/kg) was administered on the first day. In groups 3 and 4, a single dose of CP (10 mg/kg) was administered on the first day and then treated with Melissa of cinalis at 1000 mg/kg/day and vitamin E at 100 mg/kg/day for 7 consecutive days, respectively. Groups 5 and 6 were treated with Melissa of cinalis and vitamin E for 7 consecutive days, respectively. After euthanasia, serum levels of testosterone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) were evaluated. Testes were removed and weighed. Spermatic analysis was done on the tail of the epididymis. Tissue lipid peroxidation and activity of antioxidant enzymes in testes were evaluated as well. RESULTS: The results showed that Melissa of cinalis and vitamin E increased serum levels of testosterone, LH and FSH, weight of testes and sperm motility, count and vitality and decreased sperm cell abnormalities in rats given CP. CONCLUSION: Our results are useful in designing a medication of Melissa of cinalis that can protect the testes against CP-induced testicular damage and infertility in cancerous male patients.
[Mh] Termos MeSH primário: Antineoplásicos/toxicidade
Cisplatino/toxicidade
Melissa
Extratos Vegetais/administração & dosagem
Reprodução/efeitos dos fármacos
Vitamina E/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Animais
Masculino
Distribuição Aleatória
Ratos
Ratos Wistar
Reprodução/fisiologia
Motilidade Espermática/efeitos dos fármacos
Motilidade Espermática/fisiologia
Testículo/efeitos dos fármacos
Testículo/metabolismo
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); 1406-18-4 (Vitamin E); 3XMK78S47O (Testosterone); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.2174/1574892811666161026111721


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[PMID]:28124962
[Au] Autor:Ergüden C; Özkoç S; Öztürk B; Bayram Delibas S
[Ad] Endereço:Dokuz Eylul University Faculty of Medicine, Department of Parasitology, Izmir, Turkey. cerenerguden@hotmail.com.
[Ti] Título:[Investigation of the in vitro effects of Melissa officinalis L., Mentha x piperita L. and Ocimum basilicum L. (Lamiaceae) essential oils on the cysts and trophozoites of Acanthamoeba castellani].
[Ti] Título:Melissa officinalis L., Mentha x piperita L. ve Ocimum basilicum L. (Lamiaceae) uçucu yaglarinin Acanthamoeba castellani kist ve trofozoitleri üzerine in vitro etkisinin arastirilmasi..
[So] Source:Mikrobiyol Bul;50(4):569-579, 2016 Oct.
[Is] ISSN:0374-9096
[Cp] País de publicação:Turkey
[La] Idioma:tur
[Ab] Resumo:Acanthamoeba species are free living amoeba found widely all over the world. They are responsible for Acanthamoeba keratitis (AK), an infection which is especially seen in contact lens users and after minor corneal traumas, that may lead blindness. At present, antifungals and antiseptics are used for the treatment of AK cases, however, some problems such as long treatment periods and the occurrence of side effects, resistance of cyst forms against drugs, emphasize the need for new drugs. There are some published studies that pointed out the effectiveness of plant extracts and essential oils on Acanthamoeba spp. The aim of this study was to investigate the in vitro effects of essential oils of Mentha x piperita L. (peppermint), Melissa officinalis L. (lemon balm) and Ocimum basilicum L. (basil) belonging to Lamiaceae family, on the cysts and trophozoites of Acanthamoeba castellanii. The strain used in our study, namely A. castellanii T4 genotype, is the most frequently isolated amoeba from environment and also the causative agent of AK and granulomatous amebic encephalitis. For the determination of amebicidal activity, essential oils obtained from Mentha x priperita L., Melissa officinalis L. and Ocimum basilicum L. by Neo-Clevenger type of distillation apparatus have been used. In vitro experiments were performed by using 96-well microplates. Cyst and trophozoite solutions were added on the essential oil dilutions to obtain the last concentrations of 40, 20, 10, 5, 2.5 and 1.25 µg/ml for the cysts, and 10, 5, 2.5, 1.25, 0.625 and 0.313 µg/ml for the trophozoites. After the incubation of microplates at 30oC for 1, 6, 24, 48 and 72 hours, the viability of parasitic forms were evaluated under the light microscope followed by staining trypan blue. It was found that, each essential oil showed amebicidal effect on A.castellani cysts and trophozoites dependent on dosage and time, when compared with the control group, The maximum lethal effect occured with Melissa officinalis followed by Mentha x piperita and Ocimum basilicum, respectively. In our study, susceptibility of A.castellanii trophozoites to essential oils were more than the cysts, as expected. The essential oils of Melissa officinalis and Mentha x piperita showed 100% lethal effect at their highest concentrations whereas the essential oil of Ocimum basilicum showed only 63.3% lethal effect on cysts after 72 hours at the highest concentration (40 µg/mL). The results of this first study investigating the activities of essential oils extracted from Mentha x piperita, Melissa officinalis and Ocimum basilicum against Acanthamoeba spp. cysts and trophozoites, have suggested that, these essential oils could be potential novel and alternative natural products for the treatment of Acanthamoeba spp. infections.
[Mh] Termos MeSH primário: Acanthamoeba castellanii/efeitos dos fármacos
Melissa/química
Mentha piperita/química
Ocimum basilicum/química
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Ceratite por Acanthamoeba/tratamento farmacológico
Ceratite por Acanthamoeba/parasitologia
Amebíase/tratamento farmacológico
Amebíase/parasitologia
Seres Humanos
Óleos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE



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