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Pesquisa : B01.650.940.800.575.912.250.583.520.483 [Categoria DeCS]
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[PMID]:29372804
[Au] Autor:Shelepova OV; Semenova MV; Enina OL; Schanzer IA
[Ti] Título:[Genetic, phenotypic, and phytochemical polymorphism in Eastern European populations of Mentha arvensis L.]
[So] Source:Genetika;53(1):54-62, 2017 Jan.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Variability of M. arvensis from five geographically distanced populations was examined using morphological traits and phytochemical composition of essential oil and with the help of DNA fingerprinting using ISSR markers. The population differentiation based on morphological traits was weak. Analysis of the essential oil composition provided the subdivision of the sample into three groups and, on the basis of the composition of ISSR amplicons, into four groups of specimens. A high degree of genetic polymorphism of M. arvensis and substantial, though incomplete, population differentiation were identified. It was demonstrated that the population of M. arvensis from the Komi Republic was the most genetically isolated, while the populations from Moscow and Penza provinces were weakly differentiated from each other. The population from the Republic of Belarus (near Grodno) was genetically and phytochemically considerably different from the other studied populations, although morphologically indistinguishable from them. We argue that the differentiation was caused not only by the isolation by distance but also owing to the formation of three different ecotypes adapted to different climatic conditions.
[Mh] Termos MeSH primário: Genótipo
Mentha
Óleos Voláteis/metabolismo
Fenótipo
Polimorfismo Genético
[Mh] Termos MeSH secundário: Mentha/genética
Mentha/metabolismo
República da Bielorrússia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE


  2 / 340 MEDLINE  
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[PMID]:28606765
[Au] Autor:Di Sotto A; Di Giacomo S; Abete L; Bozovic M; Parisi OA; Barile F; Vitalone A; Izzo AA; Ragno R; Mazzanti G
[Ad] Endereço:Department of Physiology and Pharmacology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy. Electronic address: antonella.disotto@uniroma1.it.
[Ti] Título:Genotoxicity assessment of piperitenone oxide: An in vitro and in silico evaluation.
[So] Source:Food Chem Toxicol;106(Pt A):506-513, 2017 Aug.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus test, the comet assay and the computational prediction by Toxtree and VEGA tools. Under our experimental conditions, the monoterpene showed to induce both point mutations (i.e. frameshift, base-substitution and/or oxidative damage) and DNA damage (i.e. clastogenic or aneuploidic damage, or single-strand breaks). Computational prediction for piperitenone oxide agreed with the toxicological data, and highlighted the presence of the epoxide function and the α,ß-unsaturated carbonyl as possible structural alerts for DNA damage. However, improving the toxicological libraries for natural occurring compounds is required in order to favour the applicability of in silico models to the toxicological predictions. Further in vivo evaluations are strictly needed in order to evaluate the role of the bioavailability of the substance and the metabolic fate on its genotoxicity profile. To the best of our knowledge, these data represent the first evaluation of the genotoxicity for this flavour compound and suggest the need of further studies to assess the safety of piperitenone oxide as a flavouring agent.
[Mh] Termos MeSH primário: Monoterpenos/toxicidade
Óxidos/toxicidade
Extratos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Ensaio Cometa
Simulação por Computador
Dano ao DNA/efeitos dos fármacos
Células Hep G2
Seres Humanos
Mentha/química
Testes para Micronúcleos
Monoterpenos/química
Testes de Mutagenicidade
Mutação/efeitos dos fármacos
Óxidos/química
Extratos Vegetais/química
Salmonella typhimurium/efeitos dos fármacos
Salmonella typhimurium/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Oxides); 0 (Plant Extracts); IKR841W74D (piperitenone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE


  3 / 340 MEDLINE  
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Alves, Luiz Carlos
Texto completo SciELO Brasil
[PMID]:28327807
[Au] Autor:Matos-Rocha TJ; Cavalcanti MG; Barbosa-Filho JM; Lúcio AS; Veras DL; Marques MO; Alves LC; Brayner FA
[Ad] Endereço:Centro de Pesquisas Aggeu Magalhães, Departamento de Parasitologia, Laboratório de Biologia Celular e Molecular, Recife, PE, Brasil.
[Ti] Título:Ultrastructural study of morphological changes in Schistosoma mansoni after in vitro exposure to the monoterpene rotundifolone.
[So] Source:Rev Soc Bras Med Trop;50(1):86-91, 2017 Jan-Feb.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION:: Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus Schistosoma, affects more than 200 million people worldwide, and its control is dependent on a single drug, praziquantel. Here, we report the in vitro effect of rotundifolone, a monoterpene isolated from Mentha x villosa (Lamiaceae), on Schistosoma mansoni adult worms. METHODS:: The in vitro effect of rotundifolone on adult Schistosoma mansoni was evaluated by analysis of behavior and mortality and through a scanning electron microscopic analysis of ultrastructural changes in the tegument of the worms. RESULTS:: At concentrations of 3.54 and 7.09µg/mL-1 rotundifolone, no worm mortality was observed at any of the sampling intervals. A minor reduction in movement of the tail, suckers, and gynecophoral canal membrane was observed after 96 h of exposure to 7.09µg/mL-1 rotundifolone. At 70.96µg/mL-1, a lack of movement was observed from 72h onwards and all worms were deemed dead; similar effects were observed at 48h with 177.4µg/mL-1, and at 24h with 354.8µg/mL-1 and 700.96µg/mL-1. Rotundifolone also caused death of all parasites and separation of coupled pairs into individual males and females after 24h at 354.8µg/mL-1. CONCLUSIONS:: The main changes in the tegument induced by the different ROT treatments were: after 24h incubation, bubble lesions spread over the entire body and loss of tubercles occurred in some regions of the ventral region.
[Mh] Termos MeSH primário: Mentha/química
Monoterpenos/farmacologia
Schistosoma mansoni/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Microscopia Eletrônica de Varredura
Monoterpenos/isolamento & purificação
Testes de Sensibilidade Parasitária
Schistosoma mansoni/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monoterpenes); 6FR5IOD112 (rotundifolone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


  4 / 340 MEDLINE  
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[PMID]:28249605
[Au] Autor:Pizzolante G; Cordero C; Tredici SM; Vergara D; Pontieri P; Del Giudice L; Capuzzo A; Rubiolo P; Kanchiswamy CN; Zebelo SA; Bicchi C; Maffei ME; Alifano P
[Ad] Endereço:Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 165, 73100, Lecce, Italy.
[Ti] Título:Cultivable gut bacteria provide a pathway for adaptation of Chrysolina herbacea to Mentha aquatica volatiles.
[So] Source:BMC Plant Biol;17(1):30, 2017 Mar 02.
[Is] ISSN:1471-2229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A chemical cross-talk between plants and insects is required in order to achieve a successful co-adaptation. In response to herbivory, plants produce specific compounds, and feeding insects respond adequately7 to molecules produced by plants. Here we show the role of the gut microbial community of the mint beetle Chrysolina herbacea in the chemical cross-talk with Mentha aquatica (or watermint). RESULTS: By using two-dimensional gas chromatography-mass spectrometry we first evaluated the chemical patterns of both M. aquatica leaf and frass volatiles extracted by C. herbacea males and females feeding on plants, and observed marked differences between males and females volatiles. The sex-specific chemical pattern of the frass paralleled with sex-specific distribution of cultivable gut bacteria. Indeed, all isolated gut bacteria from females belonged to either α- or γ-Proteobacteria, whilst those from males were γ-Proteobacteria or Firmicutes. We then demonstrated that five Serratia marcescens strains from females possessed antibacterial activity against bacteria from males belonging to Firmicutes suggesting competition by production of antimicrobial compounds. By in vitro experiments, we lastly showed that the microbial communities from the two sexes were associated to specific metabolic patterns with respect to their ability to biotransform M. aquatica terpenoids, and metabolize them into an array of compounds with possible pheromone activity. CONCLUSIONS: Our data suggest that cultivable gut bacteria of Chrysolina herbacea males and females influence the volatile blend of herbivory induced Mentha aquatica volatiles in a sex-specific way.
[Mh] Termos MeSH primário: Adaptação Biológica/fisiologia
Coleópteros/microbiologia
Microbioma Gastrointestinal
Mentha/química
Compostos Orgânicos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Adaptação Biológica/efeitos dos fármacos
Animais
Bactérias/genética
Coleópteros/efeitos dos fármacos
Coleópteros/fisiologia
Feminino
Microbioma Gastrointestinal/efeitos dos fármacos
Microbioma Gastrointestinal/genética
Herbivoria
Masculino
Mentha/fisiologia
Óleos Voláteis/farmacocinética
Óleos Voláteis/farmacologia
Filogenia
Folhas de Planta/química
RNA Ribossômico 16S
Compostos Orgânicos Voláteis/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (RNA, Ribosomal, 16S); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1186/s12870-017-0986-6


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[PMID]:28208614
[Au] Autor:Mogosan C; Vostinaru O; Oprean R; Heghes C; Filip L; Balica G; Moldovan RI
[Ad] Endereço:Department of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. cmogosan@umfcluj.ro.
[Ti] Título:A Comparative Analysis of the Chemical Composition, Anti-Inflammatory, and Antinociceptive Effects of the Essential Oils from Three Species of Mentha Cultivated in Romania.
[So] Source:Molecules;22(2), 2017 Feb 10.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This work was aimed at correlating the chemotype of three species cultivated in Romania with an in vivo study of the anti-inflammatory and antinociceptive effects of essential oils. The selected species were L. var. (white peppermint), L. subsp. (spearmint), and Ehrh. (pineapple mint). Qualitative and quantitative analysis of the essential oils isolated from the selected species was performed by gas chromatography coupled with mass spectrometry (GC-MS). The anti-inflammatory activity of the essential oils was determined by the rat paw edema test induced by λ-carrageenan. The antinociceptive effect of the essential oils was evaluated by the writhing test in mice, using 1% ( / ) acetic acid solution administered intraperitonealy and by the hot plate test in mice. The results showed a menthol chemotype for , a carvone chemotype for and a piperitenone oxide chemotype for . The essential oil from L. (EOMSP) produced statistically significant and dose-dependent anti-inflammatory and antinociceptive effects.
[Mh] Termos MeSH primário: Analgésicos/química
Anti-Inflamatórios/química
Mentha/química
Óleos Voláteis/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Analgésicos/farmacologia
Animais
Anti-Inflamatórios/farmacologia
Avaliação Pré-Clínica de Medicamentos
Masculino
Camundongos
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
Ratos Wistar
Romênia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Oils, Volatile); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


  6 / 340 MEDLINE  
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[PMID]:28118142
[Au] Autor:Ebrahimi B
[Ad] Endereço:Islamic Azad University, Sanandaj Branch, Faculty of Science, Department of Chemistry, Sanandaj, Iran.
[Ti] Título:Modified Activated Carbon Prepared from Acorn Shells as a New Solid-Phase Extraction Sorbent for the Preconcentration and Determination of Trace Amounts of Nickel in Food Samples Prior to Flame Atomic Absorption Spectrometry.
[So] Source:J AOAC Int;100(2):553-559, 2017 Mar 01.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new solid-phase extraction (SPE) sorbent was introduced based on acidic-modified (AM) activated carbon (AC) prepared from acorn shells of native oak trees in Kurdistan. Hydrochloric acid (15%, w/w) and nitric acid (32.5%, w/w) were used to condition and modify AC. The IR spectra of AC and AM-AC showed that AM lead to the formation of increasing numbers of acidic functional groups on AM-AC. AM-AC was used in the SPE method for the extraction and preconcentration of Ni+2 prior to flame atomic absorption spectrometric determination at ng/mL levels in model and real food samples. Effective parameters of the SPE procedure, such as the pH of the solutions, sorbent dosage, extraction time, sample volume, type of eluent, and matrix ions, were considered and optimized. An enrichment factor of 140 was obtained. The calibration curve was linear with an R2 of 0.997 in the concentration range of 1-220 ng/mL. The RSD was 5.67% (for n = 7), the LOD was 0.352 ng/mL, and relative recoveries in vegetable samples ranged from 96.7 to 103.7%.
[Mh] Termos MeSH primário: Carvão Vegetal/química
Níquel/análise
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Brassica/química
Concentração de Íons de Hidrogênio
Mentha/química
Quercus
Espectrofotometria Atômica
Spinacia oleracea/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
16291-96-6 (Charcoal); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.16-0291


  7 / 340 MEDLINE  
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[PMID]:27927090
[Au] Autor:Ferhat M; Erol E; Beladjila KA; Çetintas Y; Duru ME; Öztürk M; Kabouche A; Kabouche Z
[Ad] Endereço:a Département de chimie, Laboratoire d'Obtention de Substances Thérapeutiques (LOST) , Université des frères Mentouri-Constantine , Constantine , Algeria.
[Ti] Título:Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica.
[So] Source:Pharm Biol;55(1):324-329, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Stachys guyoniana Noë ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine. OBJECTIVE: To investigate their antioxidant, anticholinesterase and antibacterial activities. MATERIAL AND METHODS: n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and methanol (MEMA) and chloroform (CEMA) aerial part extracts of M. aquatica and methanol (MERMA) and acetone (AERMA) roots extracts of M. aquatica were evaluated for their antioxidant activity by the ß-carotene-linoleic acid, DPPH and ABTS scavenging, CUPRAC and metal chelating assays. The anticholinesterase activity was tested against AChE and BChE. The antibacterial activity was assessed by MICs determination against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella heidelberg, Klebsiella pneumoniae, Enterobacter aerogenes and Morganella morganii strains. RESULTS: In the ß-carotene test, the CESG (IC : 2.3 ± 1.27 µg/mL) exhibited the highest activity. The BESG was the best scavenger of DPPH (IC : 2.91 ± 0.14 µg/mL). In the ABTS test, AERMA was the most active (IC : 4.21 ± 0.28 µg/mL). However, with the CUPRAC, the BESG exhibited the best activity (A : 0.15 ± 0.05 µg/mL) and was active in metal chelating assay with 48% inhibition at 100 µg/mL. The BESG was the best AChE inhibitor (IC : 5.78 ± 0.01 µg/mL) however, the AERMA showed the highest BChE inhibitory activity (IC : 19.23 ± 1.42 µg/mL). The tested extracts exhibited a good antibacterial activity. CONCLUSION: This study demonstrated good antioxidant, anticholinesterase and antibacterial potential of S. guyoniana and M. aquatica, which fits in well with their use in folk medicine.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Bactérias/efeitos dos fármacos
Inibidores da Colinesterase/farmacologia
Mentha/química
Extratos Vegetais/farmacologia
Stachys/química
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Antibacterianos/isolamento & purificação
Antioxidantes/isolamento & purificação
Bactérias/crescimento & desenvolvimento
Benzotiazóis/química
Compostos de Bifenilo/química
Butirilcolinesterase/metabolismo
Quelantes/isolamento & purificação
Quelantes/farmacologia
Cloretos/química
Inibidores da Colinesterase/isolamento & purificação
Cobre/química
Compostos Férricos/química
Ácido Linoleico/química
Testes de Sensibilidade Microbiana
Oxirredução
Fitoterapia
Picratos/química
Componentes Aéreos da Planta
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Solventes/química
Ácidos Sulfônicos/química
beta Caroteno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Chelating Agents); 0 (Chlorides); 0 (Cholinesterase Inhibitors); 0 (Ferric Compounds); 0 (Picrates); 0 (Plant Extracts); 0 (Solvents); 0 (Sulfonic Acids); 01YAE03M7J (beta Carotene); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); 789U1901C5 (Copper); 9KJL21T0QJ (Linoleic Acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); U38V3ZVV3V (ferric chloride)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE


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[PMID]:27927076
[Au] Autor:Brahmi F; Hadj-Ahmed S; Zarrouk A; Bezine M; Nury T; Madani K; Chibane M; Vejux A; Andreoletti P; Boulekbache-Makhlouf L; Lizard G
[Ad] Endereço:a Team 'Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism' EA 7270/INSERM, Faculté des Sciences Gabriel , University Bourgogne Franche Comté , Dijon , France.
[Ti] Título:Evidence of biological activity of Mentha species extracts on apoptotic and autophagic targets on murine RAW264.7 and human U937 monocytic cells.
[So] Source:Pharm Biol;55(1):286-293, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Mints (Lamiaceae) are used as traditional remedies for the treatment of several diseases. Their extracts are recognized as anti-inflammatory compounds. OBJECTIVE: This study characterized the cytotoxic effects of Mentha spicata L. (MS), Mentha pulegium L. (MP) and Mentha rotundifolia (L). Huds (MR) on macrophage cells (RAW264.7; U937) and determined their impact on apoptosis and autophagy, which can play a role in controlling inflammation. MATERIALS AND METHODS: The extracts were prepared in culture medium and tested from 25 to 400 µg/mL after 24-48 h of treatment. To show the effect of the aqueous ethanol (50%) extracts on apoptosis and authophagy, the presence of cleaved caspase-3, and the conversion of LC3-I to LC3-II was evaluated by Western blotting. RESULTS: Compared with the MTT assay, crystal violet showed a pronounced decrease in the number of cells with all extracts at 48 h. Calculated IC values were 257.31, 207.82 and 368.02 µg/mL for MS, MP and MR, respectively. A significant increase in PI positive cells was observed with all extracts at 200-400 µg/mL. Mitochondrial dysfunctions and nuclear morphological changes were detected with MS and MR extracts at 400 µg/mL. At this concentration, no cleaved caspase-3 was found whereas stabilized caspase-3 in its dimeric form was identified. MS and MR extracts also favour LC3-I to LC3-II conversion which is a criterion of autophagy. CONCLUSIONS: The cytotoxic profiles depend on the extracts considered; MS extract showed the strong activity. However, all the mint extracts studied interact with the apoptotic and autophagic pathways at elevated concentrations.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Macrófagos/efeitos dos fármacos
Mentha/química
Monócitos/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Caspase 3/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Seres Humanos
Concentração Inibidora 50
Macrófagos/metabolismo
Macrófagos/patologia
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Camundongos
Proteínas Associadas aos Microtúbulos/metabolismo
Monócitos/metabolismo
Monócitos/patologia
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Células RAW 264.7
Fatores de Tempo
Células U937
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (MAP1LC3 protein, mouse); 0 (Microtubule-Associated Proteins); 0 (Plant Extracts); EC 3.4.22.- (Casp3 protein, mouse); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE


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[PMID]:27876218
[Au] Autor:Sharma A; Rajendran S; Srivastava A; Sharma S; Kundu B
[Ad] Endereço:Centre for Rural Development and Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
[Ti] Título:Antifungal activities of selected essential oils against Fusarium oxysporum f. sp. lycopersici 1322, with emphasis on Syzygium aromaticum essential oil.
[So] Source:J Biosci Bioeng;123(3):308-313, 2017 Mar.
[Is] ISSN:1347-4421
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The antifungal effects of four essential oils viz., clove (Syzygium aromaticum), lemongrass (Cymbopogon citratus), mint (Mentha × piperita) and eucalyptus (Eucalyptus globulus) were evaluated against wilt causing fungus, Fusarium oxysporum f. sp. lycopersici 1322. The inhibitory effect of oils showed dose-dependent activity on the tested fungus. Most active being the clove oil, exhibiting complete inhibition of mycelial growth and spore germination at 125 ppm with IC value of 18.2 and 0.3 ppm, respectively. Essential oils of lemongrass, mint and eucalyptus were inhibitory at relatively higher concentrations. The Minimum inhibitory concentration (MIC) of clove oil was 31.25 ppm by broth microdilution method. Thirty one different compounds of clove oil, constituting approximately ≥99% of the oil, were identified by gas chromatography-mass spectroscopy analysis. The major components were eugenol (75.41%), E-caryophyllene (15.11%), α-humulene (3.78%) and caryophyllene oxide (1.13%). Effect of clove oil on surface morphology of F. oxysporum f. sp. lycopersici 1322 was studied by scanning electron microscopy (SEM) and atomic force microscopy (AFM). SEM observation revealed shrivelled hyphae while AFM observation showed shrunken and disrupted spores in clove oil treated samples. In pots, 5% aqueous emulsion of clove oil controlled F. oxysporum f. sp. lycopersici 1322 infection on tomato plants. This study demonstrated clove oil as potent antifungal agent that could be used as biofungicide for the control of F. oxysporum f. sp. lycopersici in both preventive and therapeutic manner.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Fusarium/efeitos dos fármacos
Óleos Voláteis/farmacologia
Syzygium/química
[Mh] Termos MeSH secundário: Cymbopogon/química
Eucalyptus/química
Eugenol/análise
Concentração Inibidora 50
Lycopersicon esculentum/microbiologia
Mentha/química
Testes de Sensibilidade Microbiana
Óleos Voláteis/química
Sesquiterpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Oils, Volatile); 0 (Sesquiterpenes); 3T8H1794QW (Eugenol); 54W56MD2WD (humulene); BHW853AU9H (caryophyllene); S2XU9K448U (caryophyllene oxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


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[PMID]:27867107
[Au] Autor:Vining KJ; Johnson SR; Ahkami A; Lange I; Parrish AN; Trapp SC; Croteau RB; Straub SCK; Pandelova I; Lange BM
[Ad] Endereço:Department of Horticulture, Oregon State University, Corvallis, OR 97331, USA. Electronic address: kelly.vining@oregonstate.edu.
[Ti] Título:Draft Genome Sequence of Mentha longifolia and Development of Resources for Mint Cultivar Improvement.
[So] Source:Mol Plant;10(2):323-339, 2017 Feb 13.
[Is] ISSN:1752-9867
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The genus Mentha encompasses mint species cultivated for their essential oils, which are formulated into a vast array of consumer products. Desirable oil characteristics and resistance to the fungal disease Verticillium wilt are top priorities for the mint industry. However, cultivated mints have complex polyploid genomes and are sterile. Breeding efforts, therefore, require the development of genomic resources for fertile mint species. Here, we present draft de novo genome and plastome assemblies for a wilt-resistant South African accession of Mentha longifolia (L.) Huds., a diploid species ancestral to cultivated peppermint and spearmint. The 353 Mb genome contains 35 597 predicted protein-coding genes, including 292 disease resistance gene homologs, and nine genes determining essential oil characteristics. A genetic linkage map ordered 1397 genome scaffolds on 12 pseudochromosomes. More than two million simple sequence repeats were identified, which will facilitate molecular marker development. The M. longifolia genome is a valuable resource for both metabolic engineering and molecular breeding. This is exemplified by employing the genome sequence to clone and functionally characterize the promoters in a peppermint cultivar, and demonstrating the utility of a glandular trichome-specific promoter to increase expression of a biosynthetic gene, thereby modulating essential oil composition.
[Mh] Termos MeSH primário: Genoma de Planta
Mentha/genética
[Mh] Termos MeSH secundário: Sequência de Bases
Melhoramento Vegetal
Doenças das Plantas/genética
Regiões Promotoras Genéticas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE



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