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Pesquisa : B01.650.940.800.575.912.250.583.520.510 [Categoria DeCS]
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  1 / 15 MEDLINE  
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[PMID]:28398103
[Au] Autor:Katoch M; Pull S
[Ad] Endereço:a Microbial Biotechnology Department , Indian Institute of Integrative Medicine (CSIR) , Jammu , India.
[Ti] Título:Endophytic fungi associated with Monarda citriodora, an aromatic and medicinal plant and their biocontrol potential.
[So] Source:Pharm Biol;55(1):1528-1535, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: The Food and Agriculture Organization has estimated that every year considerable losses of the food crops occur due to plant diseases. Although fungicides are extensively used for management of plant diseases, they are expensive and hazardous to the environment and human health. Alternatively, biological control is the safe way to overcome the effects of plant diseases and to sustain agriculture. Since Monarda citriodora Cerv. ex Lag. (Lamiaceae/Labiatae) is known for its antifungal properties, it was chosen for the study. OBJECTIVE: The isolation of endophytic fungi from M. citriodora and assessing their biocontrol potential. MATERIAL AND METHODS: The isolated endophytes were characterized using ITS-5.8 S rDNA sequencing. Their biocontrol potential was assessed using different antagonistic assays against major plant pathogens. RESULTS: Twenty-eight endophytes representing 11 genera were isolated, of which, around 82% endophytes showed biocontrol potential against plant pathogens. MC-2 L (Fusarium oxysporum), MC-14 F (F. oxysporum), MC-22 F (F. oxysporum) and MC-25 F (F. redolens) displayed significant antagonistic activity against all the tested pathogens. Interestingly, MC-10 L (Muscodor yucatanensis) completely inhibited the growth of Sclerotinia sp., Colletotrichum capsici, Aspergillus flavus and A. fumigatus in dual culture assay, whereas MC-8 L (A. oryzae) and MC-9 L (Penicillium commune) completely inhibited the growth of the Sclerotinia sp. in fumigation assay. CONCLUSIONS: Endophytes MC-2 L, MC-14 F, MC-22 F and MC-25 F could effectively be used to control broad range of phytopathogens, while MC-10 L, MC-8 L and MC-9 L could be used to control specific pathogens. Secondly, endophytes showing varying degrees of antagonism in different assays represented the chemo-diversity not only as promising biocontrol agents but also as a resource of defensive and bioactive metabolites.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Endófitos/isolamento & purificação
Fungos/isolamento & purificação
Monarda/microbiologia
[Mh] Termos MeSH secundário: Antifúngicos/farmacologia
DNA Ribossômico
Endófitos/genética
Fungos/genética
Doenças das Plantas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (DNA, Ribosomal)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1309054


  2 / 15 MEDLINE  
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[PMID]:28264654
[Au] Autor:Katoch M; Phull S; Vaid S; Singh S
[Ad] Endereço:Microbial Biotechnology Division, Indian Institute of Integrative Medicine, Jammu, India. meenusamiksha@rediffmail.com.
[Ti] Título:Diversity, Phylogeny, anticancer and antimicrobial potential of fungal endophytes associated with Monarda citriodora L.
[So] Source:BMC Microbiol;17(1):44, 2017 Mar 07.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Present study focuses on diversity and distribution analysis of endophytic fungi associated with different tissues of the Monarda citriodora Cerv. ex Lag. (Lamiaceae/Labiatae). Anticancer and antimicrobial potential of isolated endophytes have also been investigated. RESULTS: A total of twenty eight fungal endophytes belonging to 11 different genera were isolated from this plant. All the endophytic fungi belonged to the Ascomycota phylum. The leaves were immensely rich in fungal species, while roots showed the highest tissue specific fungal dominance. Out of 28 fungal species, 72% endophytic extracts were found cytotoxic against one or more human cancer cell lines. The most prominent anticancer activity (IC value <10 µg/mL) was shown by MC-14 L (Fusarium oxysporum), MC-14 F (F. oxysporum), MC-18 L (Aspergillus fumigatus), MC-24 L (Cladosporium tenuissimum), MC-25 L (Fusarium sp.), MC-26 F (F. oxysporum) extracts. 75% of the extracts showed antimicrobial activities in agar disc-diffusion assay and 27% in the tube dilution method (MIC <100 µg/mL) respectively against the tested pathogens. Extracts of MC-14 L (F. oxysporum) and MC-18 L (A. fumigatus) displayed broad spectrum antimicrobial activity. CONCLUSIONS: These results indicated that M. citriodora harbors a rich fungal endophytic community with anticancer and antimicrobial activities. The isolated endophyte MC-24 L (C. tenuissimum) has the potential to be a source of novel cytotoxic/antimicrobial compounds. This is the first report of diversity of fungal endophytes isolated from M. citriodora.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antineoplásicos/farmacologia
Biodiversidade
Endófitos/classificação
Endófitos/metabolismo
Monarda/microbiologia
Filogenia
[Mh] Termos MeSH secundário: Ascomicetos/classificação
Ascomicetos/metabolismo
Aspergillus fumigatus/metabolismo
Bactérias/efeitos dos fármacos
Linhagem Celular Tumoral/efeitos dos fármacos
Cladosporium/metabolismo
DNA Fúngico/genética
Endófitos/genética
Endófitos/isolamento & purificação
Fungos/classificação
Fungos/isolamento & purificação
Fungos/metabolismo
Fusarium/metabolismo
Células HCT116/efeitos dos fármacos
Seres Humanos
Índia
Células MCF-7/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Folhas de Planta/microbiologia
Raízes de Plantas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (DNA, Fungal)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-017-0961-2


  3 / 15 MEDLINE  
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[PMID]:28157176
[Au] Autor:Ricci D; Epifano F; Fraternale D
[Ad] Endereço:Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, sez. Biologia Vegetale, via Bramante 28 61029 Urbino (PU), Italy. donata.ricci@uniurb.it.
[Ti] Título:The Essential Oil of Monarda didyma L. (Lamiaceae) Exerts Phytotoxic Activity in Vitro against Various Weed Seed.
[So] Source:Molecules;22(2), 2017 Feb 02.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The chemical composition of the essential oil of the flowering aerial parts of Monarda didyma L. cultivated in central Italy was analyzed by Gas Chromatography/Mass Spectrometry (GC/MS). The major compounds of the oil were thymol (59.3%), p-cymene (10.3%), terpinolene (9.2%), δ-3-carene (4.4%), myrcene (3.7%), and camphene (3.4%). The essential oil was tested in vitro for its anti-germination activity against Papaver rhoeas L., Taraxacum officinale F. H. Wigg., Avena fatua L., Raphanus sativus L. and Lepidium sativum L. seeds, demonstrating good inhibitory activity in a dose-dependent way. The exposure of the employed weed seeds to M. didyma essential oil and thymol solution (59.3%) increased the level of hydrogen peroxide (H2O2) and malondialdehyde (MDA), markers of oxidative stress, in emerging 5-day-old rootlets.
[Mh] Termos MeSH primário: Monarda/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Plantas Daninhas/efeitos dos fármacos
Sementes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Germinação/efeitos dos fármacos
Peróxido de Hidrogênio/análise
Peróxido de Hidrogênio/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/metabolismo
Óleos Voláteis/isolamento & purificação
Plantas Daninhas/metabolismo
Sementes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 4Y8F71G49Q (Malondialdehyde); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE


  4 / 15 MEDLINE  
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[PMID]:28001351
[Au] Autor:Gil G; Mao P; Avula B; Ali Z; Chittiboyina AG; Khan IA; Walker LA; Wang D
[Ad] Endereço:Newomics Inc. , Emeryville, California 94608, United States.
[Ti] Título:Proteoform-Specific Protein Binding of Small Molecules in Complex Matrices.
[So] Source:ACS Chem Biol;12(2):389-397, 2017 Feb 17.
[Is] ISSN:1554-8937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Characterizing the specific binding between protein targets and small molecules is critically important for drug discovery. Conventional assays require isolation and purification of small molecules from complex matrices through multistep chromatographic fractionation, which may alter their original bioactivity. Most proteins undergo posttranslational modification, and only certain proteoforms have the right conformation with accessible domains and available residues for small molecule binding. We developed a top-down mass spectrometry (MS) centric workflow for rapid evaluation of the bioactivity of crude botanical extracts after a one-step reaction. Our assay distinguished covalent from noncovalent binding and mapped the residue for covalent binding between bioactive constituents and specific proteoforms of the target protein. We augmented our approach with a nanoflow liquid chromatography-selected reaction monitoring (SRM)-MS assay for simultaneous identification and label-free multiplex quantitation of small molecules in the crude botanical extracts. Our assay was validated for various proteoforms of human serum albumin, which plays a key role in pharmacokinetics of small molecules in vivo. We demonstrated the utility of our proteoform-specific assay for evaluating thymoquinone in crude botanical extracts, studying its pharmacokinetics in human blood, and interpreting its toxicity to human breast cancer cells in tissue culture.
[Mh] Termos MeSH primário: Produtos Biológicos
Proteínas/química
Bibliotecas de Moléculas Pequenas
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Cromatografia Líquida
Descoberta de Drogas
Seres Humanos
Monarda/química
Ligação Proteica
Espectrometria de Massas por Ionização por Electrospray/métodos
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Proteins); 0 (Small Molecule Libraries)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1021/acschembio.6b01018


  5 / 15 MEDLINE  
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[PMID]:25550774
[Au] Autor:Li H; Yang T; Li FY; Yao Y; Sun ZM
[Ad] Endereço:Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiantong University Xi'an, China.
[Ti] Título:Antibacterial activity and mechanism of action of Monarda punctata essential oil and its main components against common bacterial pathogens in respiratory tract.
[So] Source:Int J Clin Exp Pathol;7(11):7389-98, 2014.
[Is] ISSN:1936-2625
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the current research work was to study the chemical composition of the essential oil of Monarda punctata along with evaluating the essential oil and its major components for their antibacterial effects against some frequently encountered respiratory infection causing pathogens. Gas chromatographic mass spectrometric analysis revealed the presence of 13 chemical constituents with thymol (75.2%), p-cymene (6.7%), limonene (5.4), and carvacrol (3.5%) as the major constituents. The oil composition was dominated by the oxygenated monoterpenes. Antibacterial activity of the essential oil and its major constituents (thymol, p-cymene, limonene) was evaluated against Streptococcus pyogenes, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae, Haemophilus influenzae and Escherichia coli. The study revealed that the essential oil and its constituents exhibited a broad spectrum and variable degree of antibacterial activity against different strains. Among the tested strains, Streptococcus pyogenes, Escherichia coli and Streptococcus pneumoniae were the most susceptible bacterial strain showing lowest MIC and MBC values. Methicillin-resistant Staphylococcus aureus was the most resistant bacterial strain to the essential oil treatment showing relatively higher MIC and MBC values. Scanning electron microscopy revealed that the essential oil induced potent and dose-dependent membrane damage in S. pyogenes and MRSA bacterial strains. The reactive oxygen species generated by the Monarda punctata essential oil were identified using 2', 7'-dichlorofluorescein diacetate (DCFDA).This study indicated that the Monarda punctata essential oil to a great extent and thymol to a lower extent triggered a substantial increase in the ROS levels in S. pyogenes bacterial cultures which ultimately cause membrane damage as revealed by SEM results.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Monarda/química
Óleos Voláteis/farmacologia
Streptococcus pneumoniae/efeitos dos fármacos
Streptococcus pyogenes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/química
Cicloexenos/farmacologia
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Monoterpenos/farmacologia
Óleos Voláteis/química
Sistema Respiratório/microbiologia
Terpenos/farmacologia
Timol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cyclohexenes); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Terpenes); 1G1C8T1N7Q (4-cymene); 3J50XA376E (Thymol); 9B1J4V995Q (carvacrol); 9MC3I34447 (limonene)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150101
[St] Status:MEDLINE


  6 / 15 MEDLINE  
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[PMID]:23994707
[Au] Autor:Pathania AS; Guru SK; Verma MK; Sharma C; Abdullah ST; Malik F; Chandra S; Katoch M; Bhushan S
[Ad] Endereço:Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi, India; Cancer Pharmacology Division, Indian Institute of Integrative Medicine, CSIR, Jammu 180001, India.
[Ti] Título:Disruption of the PI3K/AKT/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential oil from Monarda citriodora.
[So] Source:Food Chem Toxicol;62:246-54, 2013 Dec.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have isolated an essential oil from Monarda citriodora (MC) and characterized its 22 chemical constituents with thymol (82%), carvacrol (4.82%), ß-myrcene (3.45%), terpinen-4-ol (2.78%) and p-cymene (1.53%) representing the major constituents. We have reported for the first time the chemotherapeutic potential of MC in human promyelocytic leukemia HL-60 cells by means of apoptosis and disruption of the PI3K/AKT/mTOR signaling cascade. MC and its major constituent, thymol, inhibit the cell proliferation in different types of cancer cell lines like HL-60, MCF-7, PC-3, A-549 and MDAMB-231. MC was found to be more cytotoxic than thymol in HL-60 cells with an IC50 value of 22 µg/ml versus 45 µg/ml for thymol. Both MC and thymol induce apoptosis in HL-60 cells, which is evident by Hoechst staining, cell cycle analysis and immuno-expression of Bcl-xL, caspase-3,-8,-9 and PARP-1 cleavage. Both induce apoptosis by extrinsic and intrinsic apoptotic pathways that were confirmed by enhanced expression of death receptors (TNF-R1, Fas), caspase-9, loss of mitochondrial membrane potential and regression of Bcl-2/Bax ratio. Interestingly, both MC and thymol inhibit the downstream and upstream signaling of PI3K/AKT/mTOR pathway. The degree of apoptosis induction and disruption of the PI3K signaling cascade by MC was significantly higher when compared to thymol.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Monarda/química
Óleos Voláteis/farmacologia
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Serina-Treonina Quinases TOR/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Células HL-60/efeitos dos fármacos
Seres Humanos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Óleos Voláteis/análise
Óleos Voláteis/química
Fosfatidilinositol 3-Quinases/antagonistas & inibidores
Transporte Proteico/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
Ribulose-Bifosfato Carboxilase/genética
Transdução de Sinais
Serina-Treonina Quinases TOR/antagonistas & inibidores
Timol/análise
Timol/farmacologia
Proteína X Associada a bcl-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (BAX protein, human); 0 (Oils, Volatile); 0 (bcl-2-Associated X Protein); 3J50XA376E (Thymol); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 4.1.1.39 (RbcL protein, plastid); EC 4.1.1.39 (Ribulose-Bisphosphate Carboxylase)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:131126
[Lr] Data última revisão:
131126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130903
[St] Status:MEDLINE


  7 / 15 MEDLINE  
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[PMID]:23978578
[Au] Autor:Murata T; Oyama K; Fujiyama M; Oobayashi B; Umehara K; Miyase T; Yoshizaki F
[Ad] Endereço:Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. Electronic address: murata-t@tohoku-pharm.ac.jp.
[Ti] Título:Diastereomers of lithospermic acid and lithospermic acid B from Monarda fistulosa and Lithospermum erythrorhizon.
[So] Source:Fitoterapia;91:51-9, 2013 Dec.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Monardic acids A (1) and B (2), which are (7R,8R) diastereomers of lithospermic acid (LA) and lithospermic acid B, respectively, were isolated from Monarda fistulosa. A (7S,8R) isomer (3) of LA was also isolated from this plant, and a (7R,8S) isomer (7) of LA was obtained from Lithospermum erythrorhizon. The absolute configuration of 1 was confirmed by analysis of its hydrolysates, 7-epiblechnic acid and 2R-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid. The configuration in the dihydrobenzofuran moieties of 2, 3, and 7 was extrapolated by using the phenylglycine methyl ester method and a Cotton effect at approximately 250-260 nm in their electronic circular dichroism spectra. Diastereomers (1-3 and 7) displayed moderate hyaluronidase inhibitory and histamine release inhibitory activities.
[Mh] Termos MeSH primário: Benzofuranos/isolamento & purificação
Depsídeos/isolamento & purificação
Antagonistas dos Receptores Histamínicos/isolamento & purificação
Hialuronoglucosaminidase/antagonistas & inibidores
Lithospermum/química
Monarda/química
[Mh] Termos MeSH secundário: Animais
Benzofuranos/química
Benzofuranos/farmacologia
Depsídeos/química
Depsídeos/farmacologia
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/farmacologia
Antagonistas dos Receptores Histamínicos/química
Antagonistas dos Receptores Histamínicos/farmacologia
Seres Humanos
Isomerismo
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzofurans); 0 (Depsides); 0 (Enzyme Inhibitors); 0 (Histamine Antagonists); 0 (Plant Extracts); 100IP83JAC (lithospermic acid); 121521-90-2 (lithospermic acid B); EC 3.2.1.35 (Hyaluronoglucosaminidase)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130828
[St] Status:MEDLINE


  8 / 15 MEDLINE  
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[PMID]:23919579
[Au] Autor:Tabanca N; Bernier UR; Ali A; Wang M; Demirci B; Blythe EK; Khan SI; Baser KH; Khan IA
[Ad] Endereço:National Center for Natural Products Research and ‡Department of Pharmacognosy, School of Pharmacy, The University of Mississippi , University, Mississippi 38677, United States.
[Ti] Título:Bioassay-guided investigation of two Monarda essential oils as repellents of yellow fever mosquito Aedes aegypti.
[So] Source:J Agric Food Chem;61(36):8573-80, 2013 Sep 11.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As part of an ongoing research program to identify active mosquito repellents, Monarda bradburiana Beck and Monarda fistulosa L. essential oils showed good repellent activity with minimum effective dosages (MED) of 0.055 ± 0.036 and 0.078 ± 0.027 mg/cm(2), respectively, compared to reference standard N,N-diethyl-3-methylbenzamide (DEET) (0.039 ± 0.014 mg/cm(2)). Systematic bioassay-guided fractionation of essential oils of both Monarda species was performed to identify the active repellent compounds, and isolated pure compounds were individually tested for repellency. Of the isolated compounds, carvacrol, thymol, eugenol, and carvacrol methyl ether were found to be the repellent compounds with MEDs in the range of 0.013-0.063 mg/cm(2). Active repellent compounds were also tested for larvicidal activity against 1-day-old Aedes aegypti larvae. Thymol was the best larvicide among the tested individual compounds (LD50 of 13.9 ppm). None of the individual compounds showed cytotoxicity against mammalian cells; however, the essential oils were toxic to all cell lines.
[Mh] Termos MeSH primário: Aedes
Eugenol/administração & dosagem
Repelentes de Insetos/administração & dosagem
Monarda/química
Óleos Voláteis/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Inseticidas/administração & dosagem
Larva
Monoterpenos/administração & dosagem
Timol/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Insecticides); 0 (Monoterpenes); 0 (Oils, Volatile); 3J50XA376E (Thymol); 3T8H1794QW (Eugenol); 9B1J4V995Q (carvacrol)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:131125
[Lr] Data última revisão:
131125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130808
[St] Status:MEDLINE
[do] DOI:10.1021/jf402182h


  9 / 15 MEDLINE  
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[PMID]:23082579
[Au] Autor:Fujisaki R; Kamei K; Yamamura M; Nishiya H; Inouye S; Takahashi M; Abe S
[Ad] Endereço:Teikyo University Hospital, School of Medicine, Teikyo University, Tokyo, Hachioji, Tokyo, Japan.
[Ti] Título:In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.
[So] Source:Southeast Asian J Trop Med Public Health;43(2):270-9, 2012 Mar.
[Is] ISSN:0125-1562
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone and hinokitiol) were found to be active against P. falciparum in vitro, with 50% inhibitory concentration (IC50) values equal to or less than 1.0 microg/ml. Furthermore, in vivo analysis using a rodent model confirmed the anti-plasmodial potential of subcutaneously administered sandalwood oil, and percutaneously administered hinokitiol and caraway oil against rodent P. berghei. Notably, these oils showed no efficacy when administered orally, intraperitoneally or intravenously. Caraway oil and hinokitiol dissolved in carrier oil, applied to the skin of hairless mice caused high levels in the blood, with concentrations exceeding their IC50 values.
[Mh] Termos MeSH primário: Monoterpenos/farmacologia
Óleos Voláteis/farmacologia
Plasmodium/efeitos dos fármacos
Tropolona/análogos & derivados
[Mh] Termos MeSH secundário: Administração Cutânea
Animais
Benzoquinonas/administração & dosagem
Benzoquinonas/química
Benzoquinonas/farmacologia
Carum/química
Técnicas In Vitro
Concentração Inibidora 50
Injeções Subcutâneas
Masculino
Camundongos
Monarda/química
Monoterpenos/administração & dosagem
Monoterpenos/química
Myristica fragrans/química
Óleos Voláteis/administração & dosagem
Óleos Voláteis/química
Santalum/química
Tropolona/administração & dosagem
Tropolona/química
Tropolona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoquinones); 0 (Monoterpenes); 0 (Oils, Volatile); 490-91-5 (thymoquinone); 7L6DL16P1T (Tropolone); U5335D6EBI (beta-thujaplicin)
[Em] Mês de entrada:1212
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121023
[St] Status:MEDLINE


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[PMID]:22525067
[Au] Autor:Barman AK; Parajulee MN; Sansone CG; Medina RF
[Ad] Endereço:Department of Entomology, Texas A&M University, 2475 TAMU, College Station, TX 77843, USA.
[Ti] Título:Host preference of cotton fleahopper, Pseudatomoscelis seriatus (Reuter) is not labile to geographic origin and prior experience.
[So] Source:Environ Entomol;41(1):125-32, 2012 Feb.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Several phytophagous insects exhibit distinct preference for their host plants. In widely distributed generalist insects, host preference can be influenced by geographic variation in host plant distribution and abundance as well as by prior experience. We have studied host preference of the cotton fleahopper, Pseudatomoscelis seriatus (Reuter), a pest of cotton in Texas and other neighboring states, by measuring olfactory orientation to horsemint (Monarda punctata L.) and cotton (Gossypium hirsutum L.). Horsemint is one of the primary, native, wild hosts of cotton fleahopper during late-spring and early summer in Texas, and it is commonly believed to be the main source of this pest in cotton. Although the abundance of horsemint, and therefore the fleahopper exposure to it, varies geographically, cotton fleahopper's preference for this native host-plant is maintained across two ecoregions in Texas, TX High Plains (Lubbock area) and Brazos Valley (College Station area). Similarly, preference for horsemint was retained regardless of prior experience with cotton throughout all the life stages of the insect. This fixed preference of cotton fleahopper to horsemint could be because of their ancestral insect-plant interaction, better fitness of cotton fleahopper on horsemint, and relatively low abundance of horsemint compared with cotton. Information gained from this study could be used to implement cultural control practices such as trap cropping, to develop attractants to monitor this pest, or both.
[Mh] Termos MeSH primário: Gossypium/química
Heterópteros/fisiologia
Monarda/química
Compostos Orgânicos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Animais
Feminino
Preferências Alimentares
Heterópteros/efeitos dos fármacos
Controle de Insetos
Masculino
Ninfa/efeitos dos fármacos
Ninfa/fisiologia
Odorantes/análise
Olfato
Texas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Volatile Organic Compounds)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120425
[St] Status:MEDLINE
[do] DOI:10.1603/EN11221



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