Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.520.538 [Categoria DeCS]
Referências encontradas : 107 [refinar]
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[PMID]:28407077
[Au] Autor:Sparks JT; Bohbot JD; Ristic M; Misic D; Skoric M; Mattoo A; Dickens JC
[Ad] Endereço:United States Department of Agriculture, Agricultural Research Service, Henry A. Wallace Beltsville Agricultural Research Center, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, MD.
[Ti] Título:Chemosensory Responses to the Repellent Nepeta Essential Oil and Its Major Component Nepetalactone by Aedes aegypti (Diptera: Culicidae), a Vector of Zika Virus.
[So] Source:J Med Entomol;54(4):957-963, 2017 Jul 01.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nepeta essential oil (Neo; catnip) and its major component, nepetalactone, have long been known to repel insects including mosquitoes. However, the neural mechanisms through which these repellents are detected by mosquitoes, including the yellow fever mosquito Aedes aegypti (L.), an important vector of Zika virus, were poorly understood. Here we show that Neo volatiles activate olfactory receptor neurons within the basiconic sensilla on the maxillary palps of female Ae. aegypti. A gustatory receptor neuron sensitive to the feeding deterrent quinine and housed within sensilla on the labella of females was activated by both Neo and nepetalactone. Activity of a second gustatory receptor neuron sensitive to the feeding stimulant sucrose was suppressed by both repellents. Our results provide neural pathways for the reported spatial repellency and feeding deterrence of these repellents. A better understanding of the neural input through which female mosquitoes make decisions to feed will facilitate design of new repellents and management strategies involving their use.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Ciclopentanos/farmacologia
Repelentes de Insetos/farmacologia
Nepeta/química
Óleos Voláteis/farmacologia
Neurônios Receptores Olfatórios/efeitos dos fármacos
Pironas/farmacologia
Sensilas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aedes/fisiologia
Animais
Feminino
Maxila/efeitos dos fármacos
Maxila/fisiologia
Neurônios Receptores Olfatórios/fisiologia
Sensilas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclopentanes); 0 (Insect Repellents); 0 (Oils, Volatile); 0 (Pyrones); 21651-62-7 (nepetalactone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1093/jme/tjx059


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[PMID]:28340896
[Au] Autor:Fraga BM; González-Coloma A; Alegre-Gómez S; López-Rodríguez M; Amador LJ; Díaz CE
[Ad] Endereço:Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico F. Sánchez 3, 38206, La Laguna, Tenerife, Canary Islands, Spain. Electronic address: bmfraga@ipna.csic.es.
[Ti] Título:Bioactive constituents from transformed root cultures of Nepeta teydea.
[So] Source:Phytochemistry;133:59-68, 2017 Jan.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A phytochemical study of an extract from transformed root cultures of Nepeta teydea, induced by Agrobacterium rhizogenes, led to the isolation of the following new compounds: the sesquiterpene (-)-cinalbicol, the diterpene teydeadione (6,11,14-trihydroxy-12-methoxy-abieta-5,8,11,13,15-penten-7-one), a degraded C23-triterpene (teydealdehyde) and three fatty acid esters of lanosta-7,24-dien-3ß-ol. The propyl ester of rosmarinic acid was also isolated for the first time from a natural source. In addition, two dehydroabietane diterpenes, eight triterpenes and eighteen known phenolic compounds were obtained. The antifeedant, cytotoxic and phytotoxic activities of the isolated compounds have also been investigated.
[Mh] Termos MeSH primário: Técnicas de Cultura
Nepeta/química
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Animais
Células CHO
Cricetinae
Cricetulus
Citotoxinas/química
Citotoxinas/isolamento & purificação
Citotoxinas/toxicidade
Inseticidas/química
Inseticidas/isolamento & purificação
Nepeta/crescimento & desenvolvimento
Extratos Vegetais/isolamento & purificação
Raízes de Plantas/crescimento & desenvolvimento
Spodoptera
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Insecticides); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE


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[PMID]:28302120
[Au] Autor:Bol S; Caspers J; Buckingham L; Anderson-Shelton GD; Ridgway C; Buffington CA; Schulz S; Bunnik EM
[Ad] Endereço:Cowboy Cat Ranch, Mico, TX, 78056, USA. bol@cowboycatranch.org.
[Ti] Título:Responsiveness of cats (Felidae) to silver vine (Actinidia polygama), Tatarian honeysuckle (Lonicera tatarica), valerian (Valeriana officinalis) and catnip (Nepeta cataria).
[So] Source:BMC Vet Res;13(1):70, 2017 Mar 16.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Olfactory stimulation is an often overlooked method of environmental enrichment for cats in captivity. The best known example of olfactory enrichment is the use of catnip, a plant that can cause an apparently euphoric reaction in domestic cats and most of the Pantherinae. It has long been known that some domestic cats and most tigers do not respond to catnip. Although many anecdotes exist of other plants with similar effects, data are lacking about the number of cats that respond to these plants, and if cats that do not respond to catnip respond to any of them. Furthermore, much is still unknown about which chemicals in these plants cause this response. METHODS: We tested catnip, silver vine, Tatarian honeysuckle and valerian root on 100 domestic cats and observed their response. Each cat was offered all four plant materials and a control, multiple times. Catnip and silver vine also were offered to nine tigers. The plant materials were analyzed by gas chromatography coupled with mass spectrometry to quantify concentrations of compounds believed to exert stimulating effects on cats. RESULTS: Nearly all domestic cats responded positively to olfactory enrichment. In agreement with previous studies, one out of every three cats did not respond to catnip. Almost 80% of the domestic cats responded to silver vine and about 50% to Tatarian honeysuckle and valerian root. Although cats predominantly responded to fruit galls of the silver vine plant, some also responded positively to its wood. Of the cats that did not respond to catnip, almost 75% did respond to silver vine and about one out of three to Tatarian honeysuckle. Unlike domestic cats, tigers were either not interested in silver vine or responded disapprovingly. The amount of nepetalactone was highest in catnip and only present at marginal levels in the other plants. Silver vine contained the highest concentrations of all other compounds tested. CONCLUSIONS: Olfactory enrichment for cats may have great potential. Silver vine powder from dried fruit galls and catnip were most popular among domestic cats. Silver vine and Tatarian honeysuckle appear to be good alternatives to catnip for domestic cats that do not respond to catnip.
[Mh] Termos MeSH primário: Actinidia
Felidae/fisiologia
Lonicera
Nepeta
Valeriana
[Mh] Termos MeSH secundário: Actinidia/química
Fatores Etários
Animais
Comportamento Animal
Gatos
Ciclopentanos
Feminino
Lonicera/química
Lynx/fisiologia
Masculino
Nepeta/química
Feromônios
Pironas
Olfato
Tigres
Valeriana/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclopentanes); 0 (Pheromones); 0 (Pyrones); 21651-62-7 (nepetalactone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-0987-6


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[PMID]:28183233
[Au] Autor:Mahmood H; Chaudhry MA; Masood Z; Saeed MA; Adnan S
[Ad] Endereço:a Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan.
[Ti] Título:A mechanistic evaluation of the traditional uses of Nepeta ruderalis in gastrointestinal and airway disorders.
[So] Source:Pharm Biol;55(1):1017-1021, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Nepeta ruderalis Buch.-Ham. (Lamiaceae), locally known as Badranj Boya, is an aromatic herb used traditionally as an antispasmodic, antidiarrhoeal, and anti-asthamatic remedy. OBJECTIVE: Aqueous methanolic extract of N. ruderalis was studied to investigate its traditional uses. MATERIALS AND METHODS: Study was conducted from September 2015 to February 2016. In vitro spasmolytic and broncho-relaxant activity of crude extract of N. ruderalis (whole plant) was evaluated at 0.01-10 mg/mL final bath concentration in isolated rabbit jejunum and tracheal tissues, using PowerLab data acquisition system (Transonic Systems Inc., Ithaca, NY). In vivo antidiarrhoeal activity was evaluated in castor oil-induced diarrhoeal mice at the dose of 300 and 500 mg of crude extract orally. RESULTS: Crude extract of N. ruderalis completely relaxed spontaneously contracting, high K (80 mM) and carbachol (1 µM) induced contracted jejunum with an EC value of 5.85 (5.45-6.27), 4.0 (3.80-4.23) and 2.86 (2.48-3.29), similar to verapamil. Nr.Cr relaxed high K and carbachol induced contractions, at 5 and 10 mg/mL with an EC value of 2.37 (2.11-2.67) and 3.26 (2.9-3.67), respectively, and also displaced calcium concentration-response curves toward right at 0.1 and 0.3 mg/mL. Nr.Cr exhibited antidiarrhoeal protection at a dose of 300 and 500 mg/kg, similar to verapamil, whereas no acute toxicity signs were seen up to 5 g/kg in healthy mice. DISCUSSION AND CONCLUSION: Results suggest the presence of spasmolytic and broncho-relaxant effects in the crude extract of N. ruderalis, possibly mediated through calcium channel-blocking activity, providing the pharmacological basis for its traditional uses in gastrointestinal and airway disorders.
[Mh] Termos MeSH primário: Jejuno/efeitos dos fármacos
Nepeta
Fitoterapia
Extratos Vegetais/farmacologia
Traqueia/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antidiarreicos/farmacologia
Cálcio/metabolismo
Bloqueadores dos Canais de Cálcio/farmacologia
Carbacol/farmacologia
Jejuno/fisiologia
Camundongos
Extratos Vegetais/toxicidade
Coelhos
Traqueia/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidiarrheals); 0 (Calcium Channel Blockers); 0 (Plant Extracts); 8Y164V895Y (Carbachol); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1285325


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[PMID]:28130112
[Au] Autor:Rahmati B; Beik A
[Ad] Endereço:Neurophysiology Research Center, Shahed University, 1417953836 Tehran, Iran; Department of Physiology, School of Medicine, Shahed University, 3319118651 Tehran, Iran. Electronic address: batrahmati@yahoo.com.
[Ti] Título:Prevention of morphine dependence and tolerance by Nepeta menthoides was accompanied by attenuation of Nitric oxide overproduction in male mice.
[So] Source:J Ethnopharmacol;199:39-51, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Repeated administration of morphine for chronic pain leads to dependence and tolerance that limits clinical usage. Nepeta menthoides is commonly known as Iranian Ustukhuddoos and are administered in traditional medicine for gastrodynia, bone pain, blood depurative and restlessness. AIMS OF STUDY: To investigate the effects of Nepeta menthoides on expression and acquisition of morphine dependence and tolerance in mice with regard to oxidative stress. MATERIALS AND METHODS: Morphine dependence in mice was developed by administration of gradually increasing doses of morphine twice daily for 7 consecutive days. In experimental groups, administration of Nepeta menthoides (200 and 400mg/kg), methadone and their combination were performed 60min prior to each morphine injection (for acquisition) or the last injection of morphine on test day (for expression). Morphine tolerance was measured by the tail-immersion test before and after the administration of a single dose of morphine (100mg/kg; i.p.) on the test day (8th day). Morphine dependence was also evaluated by counting the number of jumps after the injection of naloxone (5mg/kg; i.p.). RESULTS: Nepeta menthoides, similar to methadone, significantly prevented the development (but not the expression) of morphine dependence, tolerance, and potentiated morphine antinociception and also reduced (23.23±1.15) Nitric oxide (NO) overproduction (35.23±3.36) (in compared with naloxone group (6.3±0.52)). However, single and repeated application of the extract could not change high single-dose morphine analgesia. CONCLUSION: It appears that Nepeta menthoides and methadone prevented morphine dependence and tolerance, partly through inhibition of the NO overproduction.
[Mh] Termos MeSH primário: Dependência de Morfina/metabolismo
Dependência de Morfina/prevenção & controle
Nepeta
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/biossíntese
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Tolerância a Medicamentos/fisiologia
Masculino
Metadona/farmacologia
Metadona/uso terapêutico
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE


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[PMID]:27319124
[Au] Autor:Khan FU; Khanc AU; Hussain J; Khan IU; Muhammad N; Khan A; Mehmood S; Asiri AM; Khan SB; Gilani AH
[Ti] Título:Spasmolytic and Ca++ Channel Blocking Potential of Nepetolide: Isolated from Nepeta suavis.
[So] Source:Nat Prod Commun;11(5):591-2, 2016 May.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nepeta suavis is used in traditional medicine for treatment of abdominal spasm (colic). The tricyclic clerodane type diterpene, nepetolide, isolated for the first time from Nepeta suavis, was evaluated for Ca++ antagonist and antispasmodic activities. When studied in isolated rabbit jejunum, nepetolide caused concentration-dependent (0.03-100 µM) relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that nepetolide exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action, which provides scientific explanation for the medicinal application of Nepeta suavis as an antispasmodic agent.
[Mh] Termos MeSH primário: Bloqueadores dos Canais de Cálcio/isolamento & purificação
Diterpenos/farmacologia
Jejuno/efeitos dos fármacos
Nepeta/química
Parassimpatolíticos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Diterpenos/isolamento & purificação
Técnicas In Vitro
Coelhos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Calcium Channel Blockers); 0 (Diterpenes); 0 (Parasympatholytics); 0 (nepetolide)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160620
[Lr] Data última revisão:
160620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


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[PMID]:27261997
[Au] Autor:Kolouri S; Firoozabadi A; Salehi A; Zarshenas MM; Dastgheib SA; Heydari M; Rezaeizadeh H
[Ad] Endereço:Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Traditional Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Nepeta menthoides Boiss. & Buhse freeze-dried aqueous extract versus sertraline in the treatment of major depression: A double blind randomized controlled trial.
[So] Source:Complement Ther Med;26:164-70, 2016 Jun.
[Is] ISSN:1873-6963
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Depression is the most common psychiatric disorder in the world. The conventional medications for depression, however, often have significant side effects. These adverse effects of conventional therapies, have motivated researchers to study alternative options including complementary and traditional treatments for solving the problem. OBJECTIVE: To compare the efficacy of Nepeta menthoides Boiss. & Buhse freeze-dried aqueous extract with sertraline in the treatment of major depression. DESIGN AND SETTING: From April to September of 2015, 72 patients from two psychiatry clinics of Shiraz University of Medical Sciences who met the criteria for major depression based on the structured clinical interview as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, participated in a two-armed double-blind randomized controlled trial. INTERVENTION: Subjects were randomly assigned to receive Nepeta menthoides or sertraline for four weeks. OUTCOME MEASURES: Patients were evaluated in terms of the Beck Depression Inventory-II (BDI-II) total score and common side effects of medications at the base line, the second and fourth weeks, and two weeks following the intervention (i.e. in the sixth week). RESULTS: The mean changes in the Beck Depression Inventory scores in Nepeta menthoides group were significantly higher in terms of the BDI-II scores diminution as compared to that of the control (p≤0.001). Two weeks follow up after intervention showed a lower recurrence rate in the Nepeta menthoides group (p≤0.001). CONCLUSION: Nepeta menthoides may have potential benefits in the control of mood in patients suffering from major depression. Sustention of antidepressant effect and delay in the recurrence of depression could be considered worthwhile using this herb.
[Mh] Termos MeSH primário: Antidepressivos/uso terapêutico
Transtorno Depressivo Maior/tratamento farmacológico
Nepeta
Extratos Vegetais/uso terapêutico
Sertralina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Antidepressivos/administração & dosagem
Antidepressivos/efeitos adversos
Transtorno Depressivo Maior/fisiopatologia
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Medicina Arábica
Meia-Idade
Extratos Vegetais/administração & dosagem
Extratos Vegetais/efeitos adversos
Sertralina/administração & dosagem
Sertralina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Plant Extracts); QUC7NX6WMB (Sertraline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


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[PMID]:27165249
[Au] Autor:Emami SA; Asili J; Hossein Nia S; Yazdian-Robati R; Sahranavard M; Tayarani-Najaran Z
[Ad] Endereço:Department of Pharmacognosy,School of Pharmacy; Mashhad University of Medical Sciences, Mashhad, IranE-mail: tayaraninz@mums.ac.ir.
[Ti] Título:Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines.
[So] Source:Asian Pac J Cancer Prev;17(S3):125-30, 2016.
[Is] ISSN:2476-762X
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:Nepeta cataria L. has been used in traditional medicine of some countries. Here the cytotoxic and apoptogenic activity of methanol extracts, n-hexane, dichloromethane, ethyl acetate, n-butanol, and acqueous extracts and the essential oil obtained from the aerial parts of the plant were evaluated with PC3, DU-145 and MCF-7 cell lines. Cell viability, histograms of PI stained fragmented DNA in apoptotic cells and Western blot analysis of proteins involved in the cascade of apoptosis were compared in all samples. Thirty components were identified as volatile, representing 99.7% of essential oil composition after GC-MS analysis of the oil obtained from aerial parts of the N. cataria by hydro-distillation. The major oil components of the essential oil were nepetalactone stereoisomers. Comparing IC50 values showed estrogen receptor positive PC3 cells were more sensitive to the cytotoxic effects of N. cataria in comparison with low hormone-receptor presenting DU-145 cells. Among multiple extracts and essential oils of the plant, only the ethyl acetate extract could significantly decrease cell viability in PC3 cells, in a concentration dependent manner. Ethyl acetate extract of N. cataria treated cells showed a sub-G1 peak in PC3 cells in a concentration dependent manner that indicates the involvement of an apoptotic process in ethyl acetate extract-induced cell death. Western blotting analysis showed that in PC3 cells treated with ethyl acetate (48 h) caspase 3 and PARP were cleaved to active forms. Overall, the results suggest that further analytical elucidation of N. cataria in respect to finding new cytotoxic chemicals with anti-tumor activity is warranted.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Nepeta/química
Óleos Voláteis/química
Extratos Vegetais/farmacologia
Óleos Vegetais/química
Neoplasias da Próstata/patologia
[Mh] Termos MeSH secundário: Western Blotting
Neoplasias da Mama
Feminino
Citometria de Fluxo
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Masculino
Fitoterapia
Neoplasias da Próstata/tratamento farmacológico
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plant Oils)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170311
[Lr] Data última revisão:
170311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE


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[PMID]:26140331
[Au] Autor:Sharma P; Shah GC; Sharma R; Dhyani P
[Ad] Endereço:a Department of Chemistry , Kumaun University , SSJ Campus, Almora , Uttarakhand 263601 , India.
[Ti] Título:Chemical composition and antibacterial activity of essential oil of Nepeta graciliflora Benth. (Lamiaceae).
[So] Source:Nat Prod Res;30(11):1332-4, 2016 Jun.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chemical composition of the essential oil obtained from aerial parts of Nepeta graciliflora was analysed, for the first time, by GC-FID and GC-MS. A total of 27 compounds were identified, constituting over 91.44% of oil composition. The oil was strongly characterised by sesquiterpenes (86.72%), with ß-sesquiphellandrene (28.75%), caryophyllene oxide (12.15%), α-bisabolol (8.97%), α-bergamotene (8.51%), ß-bisabolene (6.33%) and ß-Caryophyllene (5.34%) as the main constituents. The in vitro activity of the essential oil was determined against four micro-organisms in comparison with chloramphenicol by the agar well diffusion and broth dilution method. The oil exhibited good activity against all tested organisms.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Nepeta/química
Óleos Voláteis/química
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Compostos Bicíclicos com Pontes/isolamento & purificação
Compostos Bicíclicos com Pontes/farmacologia
Cromatografia Gasosa-Espectrometria de Massas
Testes de Sensibilidade Microbiana
Óleos Voláteis/farmacologia
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bridged Bicyclo Compounds); 0 (Oils, Volatile); 0 (Sesquiterpenes); 0 (beta-bisabolene); 17699-05-7 (alpha-bergamotene); 24WE03BX2T (bisabolol); BHW853AU9H (caryophyllene); S2XU9K448U (caryophyllene oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150704
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1055489


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[PMID]:26611967
[Au] Autor:Sathantriphop S; Achee NL; Sanguanpong U; Chareonviriyaphap T
[Ad] Endereço:Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand.
[Ti] Título:The effects of plant essential oils on escape response and mortality rate of Aedes aegypti and Anopheles minimus.
[So] Source:J Vector Ecol;40(2):318-26, 2015 Dec.
[Is] ISSN:1948-7134
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The High Throughput Screening System (HITSS) has been applied in insecticide behavioral response studies with various mosquito species. In general, chemical or natural compounds can produce a range of insect responses: contact irritancy, spatial repellency, knock-down, and toxicity. This study characterized these actions in essential oils derived from citronella, hairy basil, catnip, and vetiver in comparison to DEET and picaridin against Aedes aegypti and Anopheles minimus mosquito populations. Results indicated the two mosquito species exhibited significantly different (P<0.05) contact irritant escape responses between treatment and control for all tested compound concentrations, except with the minimum dose of picaridin (P>0.05) against Ae. aegypti. Spatial repellency responses were elicited in both mosquito species when exposed to all compounds, but the strength of the repellent response was dependent on compound and concentration. Data show that higher test concentrations had greatest toxic effects on both mosquito populations, but vetiver had no toxic effect on Ae. aegypti and picaridin did not elicit toxicity in either Ae. aegypti or An. minimus at any test concentration. Ultimately, this study demonstrates the ability of the HITSS assay to guide selection of effective plant essential oils for repelling, irritating, and killing mosquitoes.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Anopheles/efeitos dos fármacos
Repelentes de Insetos/farmacologia
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Chrysopogon/química
Cymbopogon/química
DEET/farmacologia
Feminino
Ensaios de Triagem em Larga Escala/métodos
Inseticidas/farmacologia
Mortalidade
Nepeta/química
Piperidinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Insecticides); 0 (Oils, Volatile); 0 (Piperidines); 0 (Plant Oils); 134-62-3 (DEET); N51GQX0837 (picaridin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151128
[St] Status:MEDLINE
[do] DOI:10.1111/jvec.12170



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