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Pesquisa : B01.650.940.800.575.912.250.583.520.750 [Categoria DeCS]
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[PMID]:28155254
[Au] Autor:Bajalan I; Rouzbahani R; Pirbalouti AG; Maggi F
[Ad] Endereço:Young Researchers and Elite Club of Islamic Azad University, Borujerd Branch, Navab Street, Borujerd, Lorestan Province, Iran.
[Ti] Título:Variation in Chemical Composition and Antibacterial Activity of the Essential Oil of Wild Populations of Phlomis olivieri.
[So] Source:Chem Biodivers;14(5), 2017 May.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Various species of the genus Phlomis have been reported to produce metabolites demonstrating significant pharmacological efficiency. In this study, the essential oils from twelve populations of Phlomis olivieri collected from natural habitats were investigated for their chemical components. The hydrodistillated essential oil analyzed by GC-FID and GC/MS. Analyses revealed 27 compounds, constituting 90.52 - 98.51% of the essential oils. Results indicated that the major components of the essential oils from various populations of P. olivieri were germacrene D (26.54 - 56.41%), bicyclogermacrene (6.38 - 30.55%), ß-caryophyllene (5.32 - 24.52%) and α-pinene (1.29 - 15.53%). Principal component analyses (PCA) was used to identify any geographical variations in essential oil composition. Notably, three groups of Iranian P. olivieri populations were determined according to the major compounds. Results of the in vitro antibacterial activity indicated that P. olivieri essential oils showed good inhibitory activities against bacteria, especially Bacillus subtilis. The results of this study gave new insights for cultivation and industrial uses of P. olivieri in Iran.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Óleos Voláteis/química
Phlomis/química
[Mh] Termos MeSH secundário: Bacillus subtilis/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Irã (Geográfico)
Monoterpenos/análise
Óleos Voláteis/análise
Óleos Voláteis/farmacologia
Análise de Componente Principal
Sesquiterpenos/análise
Sesquiterpenos de Germacrano/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Germacrane); BHW853AU9H (caryophyllene); JPF3YI7O34 (alpha-pinene); V2I9ATG34E (germacrene D)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600444


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[PMID]:27641672
[Au] Autor:Mateus MC; Neves D; Dacunha B; Laczko E; Maia C; Teixeira R; Cravador A
[Ad] Endereço:Chemistry Research Centre of Algarve (CIQA), Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139, Faro, Portugal.
[Ti] Título:Structure, anti-Phytophthora and anti-tumor activities of a nortriterpenoid from the rhizome of Phlomis purpurea (Lamiaceae).
[So] Source:Phytochemistry;131:158-164, 2016 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To investigate bioactive compounds potentially involved in the biotic interactions exhibited by Phlomis purpurea (Lamiaceae) in rhizospheres infested with Phytophthora cinnamomi, the plant rhizome was chemically analysed. The nortriterpenoid (17S)-2α,3α,11α,23,24-pentahydroxy-19(18 â†’ 17)-abeo-28-norolean-12-en-18-one, was isolated and its structure was elucidated by comprehensive spectroscopic analysis, chiefly using 2D NMR experiments, and X-ray analysis. It was shown to be exuded by roots and to exhibit anti-Phytophthora and antitumor activities.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Phlomis/química
Phytophthora/efeitos dos fármacos
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Glicosídeos/química
Células HeLa
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Raízes de Plantas/química
Portugal
Rizoma/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Glycosides); 0 (Triterpenes)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160920
[St] Status:MEDLINE


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[PMID]:27220729
[Au] Autor:Chondrogiannis C; Grammatikopoulos G
[Ad] Endereço:Laboratory of Plant Physiology, Department of Biology, University of Patras, Rio, 26504, Patras, Greece.
[Ti] Título:Photosynthesis in developing leaf of juveniles and adults of three Mediterranean species with different growth forms.
[So] Source:Photosynth Res;130(1-3):427-444, 2016 Dec.
[Is] ISSN:1573-5079
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Leaf development is influenced by almost all the prevailing environmental conditions as well as from the conditions at the time of bud formation. Furthermore, the growth form of a plant determines the leaf longevity and subsequently the investment in biomass and the internal structure of the mesophyll. Therefore, photosynthetic traits of a growing leaf, though, partly predetermined, should also acclimate to temporal changes during developmental period. In addition, the age of the plant can affect photosynthesis of the growing leaf, yet, in the majority of studies, the age is associated to the size of the plant. To test if the reproductive status of the plant affects the time kinetics of the photosynthetic capacity of a growing leaf and the relative contribution of the plants' growth form to the whole procedure, field measurements were conducted in juveniles (prereproductive individuals) and adults (fully reproductive individuals) of an evergreen sclerophyllous shrub (Nerium oleander), a semi-deciduous dimorphic shrub (Phlomis fruticosa), and a winter deciduous tree with pre-leafing flowering (Cercis siliquastrum). PSII structural and functional integrity was progressively developed in all species, but already completed, only some days after leaf expansion in P. fruticosa. Developing leaf as well as fully developed leaf in adults of C. siliquastrum showed enhanced relative size of the pool of final PSI electron acceptors. Photosynthetic traits between juveniles and adults of P. fruticosa were similar, though the matured leaf of adults exhibited lower transpiration rates and improved water-use efficiency than that of juveniles. Adults of the evergreen shrub attained higher CO assimilation rate than juveniles in matured leaf which can be attributed to higher electron flow devoted to carboxylation, and lower photorespiration rate. The reproductive phase of the plant seemed to be involved in modifications of the PSII and PSI functions of the deciduous tree, in carboxylation and photorespiration traits of the evergreen shrub, and in water conductance efficiency of the semi-deciduous shrub. However, it is interesting, that regardless of the growth form of the plant and the prospective leaf longevity of the developing leaf, adults need to support flowering outmatch juveniles, in terms of photosynthesis.
[Mh] Termos MeSH primário: Fabaceae/crescimento & desenvolvimento
Nerium/crescimento & desenvolvimento
Phlomis/crescimento & desenvolvimento
Fotossíntese/fisiologia
Folhas de Planta/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Clorofila/análise
Clorofila/fisiologia
Fabaceae/fisiologia
Fluorescência
Região do Mediterrâneo
Nerium/fisiologia
Nitrogênio/análise
Phlomis/fisiologia
Folhas de Planta/química
Folhas de Planta/fisiologia
Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 1406-65-1 (Chlorophyll); N762921K75 (Nitrogen)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160526
[St] Status:MEDLINE


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[PMID]:27217745
[Au] Autor:Anjum S; Abbasi BH
[Ad] Endereço:Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.
[Ti] Título:Biomimetic synthesis of antimicrobial silver nanoparticles using in vitro-propagated plantlets of a medicinally important endangered species: Phlomis bracteosa.
[So] Source:Int J Nanomedicine;11:1663-75, 2016.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:In vitro-derived cultures of plants offer a great potential for rapid biosynthesis of chemical-free antimicrobial silver nanoparticles (AgNPs) by enhancing their phytochemical reducing potential. Here, we developed an efficient protocol for in vitro micropropagation of a high-value endangered medicinal plant species, Phlomis bracteosa, in order to explore its biogenic potential in biomimetic synthesis of antimicrobial AgNPs. Murashige and Skoog medium supplemented with 2.0 mg/L thidiazuron was found to be more efficient in inducing optimum in vitro shoot regeneration (78%±4.09%), and 2.0 mg/L indole-3-butyric acid was used for maximum root induction (86%±4.457%). Antimicrobial AgNPs were successfully synthesized by using aqueous extract (rich in total phenolics and flavonoids content) of in vitro derived plantlets of P. bracteosa. Ultraviolet-visible spectroscopy of synthesized AgNPs showed characteristic surface plasmon band in the range of 420-429 nm. The crystallinity, size, and shape of the AgNPs were characterized by X-ray diffraction and scanning electron microscopy. Face-centered cubic AgNPs of almost uniform spherical size (22.41 nm) were synthesized within a short time (1 hour) at room temperature. Fourier-transform infrared spectroscopy revealed that the polyphenols were mainly responsible for reduction and capping of synthesized AgNPs. Energy dispersive X-ray analysis further endorsed the presence of elemental silver in synthesized AgNPs. These biosynthesized AgNPs displayed significantly higher bactericidal activity against multiple drug-resistant human pathogens. The present work highlighted the potent role of in vitro-derived plantlets of P. bracteosa for feasible biosynthesis of antimicrobial AgNPs, which can be used as nanomedicines in many biomedical applications.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Biomimética/métodos
Espécies em Perigo de Extinção
Nanopartículas Metálicas/química
Phlomis/crescimento & desenvolvimento
Plantas Medicinais/crescimento & desenvolvimento
Prata/farmacologia
[Mh] Termos MeSH secundário: Aclimatação/efeitos dos fármacos
Anti-Infecciosos/química
Bactérias/efeitos dos fármacos
Seres Humanos
Indóis/farmacologia
Cinética
Testes de Sensibilidade Microbiana
Phlomis/efeitos dos fármacos
Extratos Vegetais/química
Raízes de Plantas/efeitos dos fármacos
Brotos de Planta/efeitos dos fármacos
Plantas Medicinais/efeitos dos fármacos
Regeneração/efeitos dos fármacos
Espectrometria por Raios X
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Indoles); 0 (Plant Extracts); 061SKE27JP (indolebutyric acid); 3M4G523W1G (Silver)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S105532


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[PMID]:27070559
[Au] Autor:Lee D; Kim YS; Song J; Kim HS; Lee HJ; Guo H; Kim H
[Ad] Endereço:Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Korea. allstart2925@naver.com.
[Ti] Título:Effects of Phlomis umbrosa Root on Longitudinal Bone Growth Rate in Adolescent Female Rats.
[So] Source:Molecules;21(4):461, 2016 Apr 07.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This study aimed to investigate the effects of Phlomis umbrosa root on bone growth and growth mediators in rats. Female adolescent rats were administered P. umbrosa extract, recombinant human growth hormone or vehicle for 10 days. Tetracycline was injected intraperitoneally to produce a glowing fluorescence band on the newly formed bone on day 8, and 5-bromo-2'-deoxyuridine was injected to label proliferating chondrocytes on days 8-10. To assess possible endocrine or autocrine/paracrine mechanisms, we evaluated insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) or bone morphogenetic protein-2 (BMP-2) in response to P. umbrosa administration in either growth plate or serum. Oral administration of P. umbrosa significantly increased longitudinal bone growth rate, height of hypertrophic zone and chondrocyte proliferation of the proximal tibial growth plate. P. umbrosa also increased serum IGFBP-3 levels and upregulated the expressions of IGF-1 and BMP-2 in growth plate. In conclusion, P. umbrosa increases longitudinal bone growth rate by stimulating proliferation and hypertrophy of chondrocyte with the increment of circulating IGFBP-3. Regarding the immunohistochemical study, the effect of P. umbrosa may also be attributable to upregulation of local IGF-1 and BMP-2 expressions in the growth plate, which can be considered as a GH dependent autocrine/paracrine pathway.
[Mh] Termos MeSH primário: Desenvolvimento Ósseo/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Tíbia/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Proteína Morfogenética Óssea 2/biossíntese
Condrócitos/efeitos dos fármacos
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Lâmina de Crescimento/efeitos dos fármacos
Lâmina de Crescimento/crescimento & desenvolvimento
Seres Humanos
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina/biossíntese
Fator de Crescimento Insulin-Like I/biossíntese
Phlomis/química
Extratos Vegetais/química
Raízes de Plantas/química
Ratos
Tíbia/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bmp2 protein, rat); 0 (Bone Morphogenetic Protein 2); 0 (Insulin-Like Growth Factor Binding Protein 3); 0 (Plant Extracts); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160413
[St] Status:MEDLINE


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[PMID]:26612318
[Au] Autor:Georgescu L; Stefanakis MK; Kokkini S; Katerinopoulos HE; Pirintsos SA
[Ad] Endereço:Department of Biology, University of Crete, Heraklion 714 09, Crete, Greece.
[Ti] Título:Chemical and genetic characterization of Phlomis species and wild hybrids in Crete.
[So] Source:Phytochemistry;122:91-102, 2016 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The genus Phlomis is represented in the island of Crete (Greece, Eastern Mediterranean) by three species Phlomis cretica C. Presl., Phlomis fruticosa L., the island endemic Phlomis lanata Willd. and three hybrids Phlomis x cytherea Rech.f. (P. cretica x P. fruticosa), Phlomis x commixta Rech.f. (P. cretica x P. lanata) and Phlomis x sieberi Vierh. (P. fruticosa x P. lanata). This work describes (a) the profile of hybrids and parental species concerning their volatile compounds, (b) the suitability of ribosomal nuclear (ITS region), chloroplast (trnH-psbA), and AFLP markers to identify hybrids and (c) their competence to characterize the different chemotypes of both hybrids and their parental species. The cluster analysis and PCA constructed from chemical data (volatile oils) suggest that there are three groups of taxa. Group IA includes P. cretica and P. fruticosa, group IB includes P. x cytherea, whereas group II consists of P. x commixta, P. x sieberi and P. lanata. Volatile compounds detected only in the hybrids P. x sieberi and P. x commixta correspond to the 3% of the total compounds, value that is much higher in P. x cytherea (21%). Neighbor-joining, statistical parsimony analysis and the observations drawn from ribotypes spectrum of ITS markers divided Phlomis species in two groups, P. lanata and the complex P. cretica/P. fruticosa. In contrast to the ITS region, the plastid DNA marker follows a geographically related pattern. Neighbor-Net, PCA and Bayesian assignment analysis performed for AFLP markers separated the genotypes into three groups corresponding to populations of P. cretica, P. fruticosa, and P. lanata, respectively, while populations of P. x commixta, P. x cytherea, and P. x sieberi presented admixed ancestry. Most of the P. x cytherea samples were identified as F1 hybrids by Bayesian assignment test, while those of P. x commixta and P. x sieberi were identified as F2 hybrids. Overall, high chemical differentiation is revealed in one of the three hybrids, which is likely related with niche variation. Moreover, molecular markers show potential to identify Phlomis taxa.
[Mh] Termos MeSH primário: Óleos Voláteis/química
Phlomis/química
[Mh] Termos MeSH secundário: Marcadores Genéticos
Grécia
Phlomis/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Genetic Markers); 0 (Oils, Volatile)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151128
[St] Status:MEDLINE


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[PMID]:25845642
[Au] Autor:Karali D; Georgescu L; Pirintsos S; Athanassakis I
[Ad] Endereço:a Laboratory of Immunology, Department of Biology , University of Crete , Crete , Greece .
[Ti] Título:T cell regulation by Phlomis lanata protein extracts in mice.
[So] Source:Pharm Biol;54(2):207-14, 2016.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Phytopharmacology is a complex but very promising research area. The different plant parts and extraction methods may result in opposed effects. Phlomis species have been reported for both anti-inflammatory and tonic properties. OBJECTIVE: The effect of Phlomis lanata Willd. (Lamiaceae) protein extracts on immune cell reactivity was studied in the experimental mouse model. MATERIALS AND METHODS: Protein extracts from P. lanata aerial parts were fractionated by Q-sepharose ion-exchange chromatography and applied to whole spleen cells or T-cell subsets at 5 µg/ml. Cell growth and cytokine production were evaluated after 4 and 2 d of culture using (3)H-thymidine-uptake and ELISA techniques, respectively. RESULTS: Among the protein fractions tested, column wash proteins (W1) and the fraction eluted using 600 mM NaCl (F6) reduced by 76% and increased by 78% spleen cell proliferation, respectively. W1 suppressed proliferation of effector T-cells, but stimulated the growth of suppressor/regulatory cells by 62-148%. Although W1 stimulated IL-2 and IL-10 production from total spleen cells, it significantly increased IL-10 (50%) and reduced IL-2 (30-50%) production from T-cells, while TNF-α release was enhanced in CD25(+)CD4(+) by 92% and reduced by 50% in CD25(+)CD8(+) cells. F6 stimulated whole spleen cell growth, reduced proliferation of CD8(+) and CD25(+) cells by approximately 50%, while decreasing by 60-80% TNF-α production from CD25(-) and CD25(+)CD8(+) cells. DISCUSSION AND CONCLUSION: The suppressive activity of W1 could be attributed to IL-10 and TNF-α, while the stimulatory effect of F6 could be attributed to the inhibition of T-regulatory cells. In the same plant, coexisting protein fractions induce both immunostimulatory and immunosuppressive activities.
[Mh] Termos MeSH primário: Fatores Imunológicos/farmacologia
Phlomis/química
Extratos Vegetais/farmacologia
Proteínas de Plantas/química
Baço/efeitos dos fármacos
Subpopulações de Linfócitos T/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Técnicas de Cultura de Células
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Citometria de Fluxo
Fatores Imunológicos/isolamento & purificação
Interleucina-10/biossíntese
Interleucina-2/biossíntese
Masculino
Camundongos Endogâmicos BALB C
Componentes Aéreos da Planta/química
Extratos Vegetais/isolamento & purificação
Baço/citologia
Baço/imunologia
Subpopulações de Linfócitos T/imunologia
Linfócitos T Reguladores/efeitos dos fármacos
Linfócitos T Reguladores/imunologia
Fator de Necrose Tumoral alfa/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (IL10 protein, mouse); 0 (Immunologic Factors); 0 (Interleukin-2); 0 (Plant Extracts); 0 (Plant Proteins); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151208
[Lr] Data última revisão:
151208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150408
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1027780


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[PMID]:26276095
[Au] Autor:Yahiaoui M; Hadoun H; Toumert I; Hassani A
[Ad] Endereço:Laboratoire de recherche sur les produits bioactifs et valorisation de la biomasse, Ecole Normale Supérieure (ENS) de Kouba, BP 92 Algiers, Algeria.
[Ti] Título:Determination of kinetic parameters of Phlomis bovei de Noé using thermogravimetric analysis.
[So] Source:Bioresour Technol;196:441-7, 2015 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper reports the pyrolysis study of Phlomis bovei biomass by thermogravimetric experiments in order to determine the thermal degradation behavior and kinetic parameters. The weight losses were found to occur in three stages. In the DTG thermograms, an increase of the heating rate tended to delay thermal degradation processes towards higher temperatures. The average values of activation energy and pre-exponential factor calculated from Ozawa-Flynn-Wall, Kissinger-Akahira-Sunose and Kissinger methods are 134.83, 134.06, 223.31kJ/mol and 4.1610(13), 1.1810(10), 2.8110(11)/s, respectively. The three-pseudo-component method shows that the activation energy increases with increasing the heating rate for hemicellulose and cellulose while the activation energy of the lignin decreased with an increase of the heating rate. Predicted results and experimental data exhibit similar tendencies and the three pseudo-components model with n different from unity 1 is recommended as the most suitable for prediction of kinetic behavior of Phlomis bovei de Noé.
[Mh] Termos MeSH primário: Phlomis/química
Termogravimetria/métodos
[Mh] Termos MeSH secundário: Biomassa
Celulose/química
Temperatura Alta
Cinética
Lignina/química
Modelos Teóricos
Polissacarídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polysaccharides); 8024-50-8 (hemicellulose); 9004-34-6 (Cellulose); 9005-53-2 (Lignin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150816
[St] Status:MEDLINE


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[PMID]:26263166
[Au] Autor:Li Q; Yang S; Yang S; Xin F; Wang M
[Ad] Endereço:Department of Anesthesia, the Third Hospital of Jinan, Jinan 250132, PR China. Electronic address: qzlijnyy@126.com.
[Ti] Título:Anti-inflammatory activity of phlomisoside F isolated from Phlomis younghusbandii Mukerjee.
[So] Source:Int Immunopharmacol;28(1):724-30, 2015 Sep.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study was designed to investigate the anti-inflammatory effect of phlomisoside F (PMF) isolated from Phlomis younghusbandii and to explore the possible pharmacological mechanisms. Anti-inflammatory effects of PMF were evaluated by using carrageenan-induced rat paw edema test, dimethylbenzen-induced ear edema test, acetic acid-induced vascular permeability and cotton pellet granuloma test. Furthermore, the releases of pro-inflammatory cytokines (TNF-α, IL-6 and IL-1ß) were determined by ELISA. To explore the potential mechanisms, expressions of iNOS and COX-2 were determined by quantitative real-time PCR and western blotting assays. In addition, the expressions of nuclear p65, cytosolic p65, IκB, p38, p-p38, p-ERK1/2, ERK1/2, JNK and p-JNK were determined by western blotting assay. Our results indicated that PMF administered orally could not only significantly decrease rat paw edema in rats and ear edema in mice, but also reduce the vascular permeability in mice and granuloma weights in rats. In vitro, the releases of LPS-induced pro-inflammatory cytokines (TNF-α, IL-6, IL-1ß) and enzymes (iNOS and COX-2) were decreased significantly by PMF treatment in RAW 264.7 cells. In addition, the LPS-induced up-regulations of nuclear p65, p38, p-p38, p-ERK1/2, JNK and p-JNK proteins in RAW 264.7 cells significantly decreased by PMF, and expressions of cytosolic p65 and IκB were obviously up-regulated after treatment with PMF. In conclusion, we suggested that the PMF is a promising potential anti-inflammatory drug, and PMF could down-regulate expressions of pro-inflammatory cytokines and mediators by inhibiting the NF-κB/MAPK pathways.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Diterpenos/farmacologia
Glucosídeos/farmacologia
Phlomis/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/uso terapêutico
Western Blotting
Permeabilidade Capilar/efeitos dos fármacos
Permeabilidade Capilar/imunologia
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Ciclo-Oxigenase 2/biossíntese
Diterpenos/isolamento & purificação
Diterpenos/uso terapêutico
Edema/tratamento farmacológico
Edema/imunologia
Ensaio de Imunoadsorção Enzimática
Glucosídeos/isolamento & purificação
Glucosídeos/uso terapêutico
Granuloma/tratamento farmacológico
Granuloma/imunologia
Interleucina-1beta/secreção
Interleucina-6/secreção
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Masculino
Medicina Tradicional Chinesa
Camundongos
Óxido Nítrico Sintase Tipo II/biossíntese
Ratos Sprague-Dawley
Fator de Necrose Tumoral alfa/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (15,16-epoxy-8(9),13(16),14-labdatrien-7-ketone-19-oic acid glucopyranosyl ester); 0 (Anti-Inflammatory Agents); 0 (Diterpenes); 0 (Glucosides); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, rat); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150831
[Lr] Data última revisão:
150831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE


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[PMID]:25890391
[Au] Autor:Bader A; Tuccinardi T; Granchi C; Martinelli A; Macchia M; Minutolo F; De Tommasi N; Braca A
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, P.O. Box 13174, 21955 Makkah, Saudi Arabia.
[Ti] Título:Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.
[So] Source:Phytochemistry;116:262-268, 2015 Aug.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two flavonoids, jaceosidin 7-O-ß-d-glucopyranosyl-(1→2)-ß-d-glucopyranoside (1) and hispidulin 7-O-ß-d-glucopyranosyl-(1→2)-ß-d-glucopyranoside (2), and one phenylpropanoid, 3,3'-dimethyl-lunariifolioside (3), along with 11 known compounds (4-14), were isolated from the aerial parts of Phlomis kurdica growing in Jordan. Structures of 1-3 were elucidated on the basis of spectroscopic data. These isolated compounds were assayed for their inhibitory activity against isoform 5 of human lactate dehydrogenase. Compound 4, luteolin 7-O-ß-d-glucopyranoside, showed an IC50 value comparable to that of galloflavin, used as reference compound. Docking studies were carried out to hypothesize the interaction mode of compound 4 in the enzyme active site.
[Mh] Termos MeSH primário: Flavonoides/isolamento & purificação
Flavonoides/farmacologia
L-Lactato Desidrogenase/antagonistas & inibidores
Fenilpropionatos/isolamento & purificação
Fenilpropionatos/farmacologia
Phlomis/química
[Mh] Termos MeSH secundário: Flavonoides/química
Seres Humanos
Jordânia
Estrutura Molecular
Fenilpropionatos/química
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Flavonoids); 0 (Phenylpropionates); 18085-97-7 (jaceosidin); EC 1.1.1.27 (L-Lactate Dehydrogenase)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150420
[St] Status:MEDLINE



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