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[PMID]: 28359196 [Au] Autor: Namgung S; Yoon JJ; Yoon CS; Han BH; Choi ES; Oh H; Kim YC; Lee YJ; Kang DG; Lee HS [Ad] Endereço: * College of Oriental Medicine and Professional, Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea. [Ti] Título: Prunella vulgaris Attenuates Diabetic Renal Injury by Suppressing Glomerular Fibrosis and Inflammation. [So] Source: Am J Chin Med;45(3):475-495, 2017. [Is] ISSN: 0192-415X [Cp] País de publicação: Singapore [La] Idioma: eng [Ab] Resumo: Diabetic nephropathy is both the most common complication and the leading cause of mortality associated with diabetes. Prunella vulgaris, a well-known traditional medicinal plant, is used for the cure of abscess, scrofula, hypertension and urinary diseases. This study confirmed whether an aqueous extract of Prunella vulgaris (APV) suppresses renal inflammation and fibrosis. In human mesangial cell (HMC), pretreatment of APV attenuated 25[Formula: see text]mM HG-induced suppressed TGF-[Formula: see text] and Smad-2/4 expression; it increased the expression level of Smad-7. Connective tissue growth factor (CTGF) and collagen IV, fibrosis biomarkers, were significantly decreased by APV. APV suppressed inflammatory factors such as intracellular cell adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1). APV inhibited activation and translocation of nuclear factor kappa-B (NF-[Formula: see text]B) in HG-stimulated HMCs. Moreover, APV significantly improved HG-induced ROS in a dose-dependent manner. In diabetic rat models, APV significantly decreased blood glucose, blood urea nitrogen (BUN) and ameliorated plasma creatinine (PCr). APV reduced the PAS positivity staining intensity and basement membrane thickening in glomeruli of diabetic rats. Fibrosis related proteins such as collagen IV and TGF-[Formula: see text]1 were also inhibited by APV. These results suggest that APV has a significant protective effect against diabetic renal dysfunction including inflammation and fibrosis through disruption of the TGF-[Formula: see text]/Smad signaling. Therefore, APV may be useful in potential therapies that target glomerulonephritis and glomerulosclerosis, which lead to diabetic nephropathy. [Mh] Termos MeSH primário: Nefropatias Diabéticas/tratamento farmacológico Glomerulonefrite/tratamento farmacológico Inflamação/tratamento farmacológico Glomérulos Renais/patologia Terapia de Alvo Molecular Fitoterapia Extratos Vegetais/isolamento & purificação Extratos Vegetais/uso terapêutico Prunella/química [Mh] Termos MeSH secundário: Animais Células Cultivadas Quimiocina CCL2/metabolismo Colágeno/metabolismo Fator de Crescimento do Tecido Conjuntivo/metabolismo Nefropatias Diabéticas/metabolismo Nefropatias Diabéticas/patologia Modelos Animais de Doenças Relação Dose-Resposta a Droga Fibrose/tratamento farmacológico Fibrose/metabolismo Seres Humanos Molécula 1 de Adesão Intercelular/metabolismo Masculino Extratos Vegetais/farmacologia Ratos Sprague-Dawley Espécies Reativas de Oxigênio/metabolismo Fator de Crescimento Transformador beta1/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ccl2 protein, rat); 0 (Chemokine CCL2); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (Transforming Growth Factor beta1); 126547-89-5 (Intercellular Adhesion Molecule-1); 139568-91-5 (Connective Tissue Growth Factor); 9007-34-5 (Collagen) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170919 [Lr] Data última revisão: 170919 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170401 [St] Status: MEDLINE [do] DOI: 10.1142/S0192415X1750029X

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[PMID]: 28001065 [Au] Autor: Qu Z; Zhang J; Yang H; Gao J; Chen H; Liu C; Gao W [Ad] Endereço: Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China. [Ti] Título: Prunella vulgaris L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats. [So] Source: J Agric Food Chem;65(2):291-300, 2017 Jan 18. [Is] ISSN: 1520-5118 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Prunella vulgaris L. is as a major plant in the Chinese traditional functional beverage Guangdong herbal tea for the treatment of fevers, diarrhea, and sore mouth. In this study, ethyl acetate parts of aqueous extracts from P. vulgaris L. (EtOAc-APV) were found to demonstrate potent acetylcholinesterase (AChE) inhibition in vitro. Therefore, this study was designed to further investigate the effects of EtOAc-APV on scopolamine (SCOP)-induced aging rats. Male Wistar rats were randomly divided into four groups (n = 12) and given orally by gavage EtOAc-APV (100 mg/kg) for 3 weeks. SCOP (1 mg/kg, ip) was administered to rats 30 min before starting behavioral tests consecutively for 3 days. EtOAc-APV could attenuate SCOP-induced brain senescence in rats by improving behavioral performance and decreasing brain cell damage, which was associated with a notable reduction in AChE activity and MDA level, as well as an increase in SOD and GPx activities. Additionally, EtOAc-APV administration could reduce the expression of NF-κB and GFAP, which showed an anti-neuroinflammatory effect on the SCOP-treated rat. Overall, the current study highlights P. vulgaris L. as an antidementia dietary supplement. [Mh] Termos MeSH primário: Transtornos da Memória/tratamento farmacológico Extratos Vegetais/farmacologia Prunella/química Hidrobrometo de Escopolamina/efeitos adversos [Mh] Termos MeSH secundário: Animais Apoptose/efeitos dos fármacos Ácidos Cafeicos/análise Inibidores da Colinesterase/farmacologia Cinamatos/análise Depsídeos/análise Flavonoides/análise Hipocampo/efeitos dos fármacos Hipocampo/metabolismo Masculino Transtornos da Memória/induzido quimicamente NF-kappa B/metabolismo Fármacos Neuroprotetores/farmacologia Plantas Medicinais/química Ratos Wistar [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Caffeic Acids); 0 (Cholinesterase Inhibitors); 0 (Cinnamates); 0 (Depsides); 0 (Flavonoids); 0 (NF-kappa B); 0 (Neuroprotective Agents); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide); MQE6XG29YI (rosmarinic acid); U2S3A33KVM (caffeic acid) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170502 [Lr] Data última revisão: 170502 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161222 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jafc.6b04597

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[PMID]: 27768926 [Au] Autor: Raafat K; Wurglics M; Schubert-Zsilavecz M [Ad] Endereço: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, Lebanon. Electronic address: k.raafat@bau.edu.lb. [Ti] Título: Prunella vulgaris L. active components and their hypoglycemic and antinociceptive effects in alloxan-induced diabetic mice. [So] Source: Biomed Pharmacother;84:1008-1018, 2016 Dec. [Is] ISSN: 1950-6007 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: Prunella vulgaris L. (Lamiaceae) (PV) is a herbaceous plant traditionally utilized in management of diabetes and it has immunomodulatory activity. In this study, acute and subchronic antidiabetic, in-vivo antioxidant and antinociceptive effects of PV were evaluated in alloxan-induced type 1 diabetes (T1D) in a mouse model. Bio-guided fractionation, isolation, RP-HPLC, and H and C NMR identification of the active components responsible for PV effects were determined. RP-HPLC analysis showed that PV contained rosmarinic acid (RA) 4.5%, caffeic acid (CA) 9.8% and p-coumaric acid (pCA) 11.6%. Bio-guided fractionation showed that PV most active fraction was rich in caffeic acid, hence named, caffeic acid-rich fraction (CARF). RP-HPLC, and H and C NMR experiments showed that CARF contained CA (93.4%) and RA (6.6%). CARF reduced blood glucose levels and improved in-vivo oxidative-stress. It also inhibited the carbohydrate-hydrolyzing enzymes (alpha-amylase and alpha-glucosidase) and reduced HbA1c levels more significantly (p≤0.05) than that of PV and equivalent amounts of CA or RA. For longer times, CARF had significantly (p≤0.05) increased serum-insulin, ameliorated thermal hyperalgesia and tactile allodynia more significantly (p≤0.05) than the effects of PV and equivalent amounts of CA or RA. Moreover, the tested compounds showed potential restoration of the lipid peroxide levels. Consequently, CARF and PV observed increase in serum-insulin, attenuation of alpha-amylase and alpha-glucosidase, and their antioxidant potentials might be responsible for their antidiabetogenic and antinociceptive properties. In conclusion, CARF isolated from PV could be a potential therapeutic agent to ameliorate T1D and related complications. [Mh] Termos MeSH primário: Analgésicos/farmacologia Glicemia/efeitos dos fármacos Diabetes Mellitus Experimental/tratamento farmacológico Neuropatias Diabéticas/tratamento farmacológico Hipoglicemiantes/farmacologia Nociceptividade/efeitos dos fármacos Extratos Vegetais/farmacologia Prunella [Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação Animais Biomarcadores/sangue Glicemia/metabolismo Espectroscopia de Ressonância Magnética Nuclear de Carbono-13 Cromatografia Líquida de Alta Pressão Cromatografia de Fase Reversa Diabetes Mellitus Experimental/sangue Diabetes Mellitus Experimental/induzido quimicamente Neuropatias Diabéticas/induzido quimicamente Neuropatias Diabéticas/fisiopatologia Relação Dose-Resposta a Droga Hemoglobina A Glicada/metabolismo Inibidores de Glicosídeo Hidrolases/isolamento & purificação Inibidores de Glicosídeo Hidrolases/farmacologia Hipoglicemiantes/isolamento & purificação Inflorescência Insulina/sangue Peroxidação de Lipídeos/efeitos dos fármacos Masculino Camundongos Estresse Oxidativo/efeitos dos fármacos Limiar da Dor/efeitos dos fármacos Fitoterapia Extratos Vegetais/isolamento & purificação Plantas Medicinais Espectroscopia de Prótons por Ressonância Magnética Prunella/química Tempo de Reação/efeitos dos fármacos Estreptozocina Fatores de Tempo alfa-Amilases/antagonistas & inibidores alfa-Amilases/sangue [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Analgesics); 0 (Biomarkers); 0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (Glycoside Hydrolase Inhibitors); 0 (HbA(1c) protein, mouse); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts); 5W494URQ81 (Streptozocin); EC 3.2.1.1 (alpha-Amylases) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161022 [St] Status: MEDLINE

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[PMID]: 27573738 [Au] Autor: Peng J; Ren X; Lan T; Chen Y; Shao Z; Yang C [Ad] Endereço: Department of Nephrology, Wuhan General Hospital of Guangzhou Military Area, Wuhan, Hubei 430030, P.R. China. [Ti] Título: Renoprotective effects of ursolic acid on ischemia/reperfusion­induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF­κB activities. [So] Source: Mol Med Rep;14(4):3397-402, 2016 Oct. [Is] ISSN: 1791-3004 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: Ursolic acid, a pentacyclic triterpene compound with low toxicity and easy availability, has a variety of biological activities, including antitumor, antioxidant, antihepatitis, anti­inflammatory and antibacterial effects. The present study aimed to investigate the renoprotective effects of ursolic acid on ischemia/reperfusion­induced acute kidney injury (I/R­IAKI) in rats associated with its antioxidant and anti­inflammatory effects, as well as interference with the signal transducer and activator of transcription (STAT)3/nuclear factor (NF)­κB signaling pathway. The present study demonstrated that pre­treatment with ursolic acid significantly increased renal functioning and attenuated increases of serum angiotensin II levels in rats subjected to I/R­IAKI. In addition, I/R­IAKI­induced inflammation and oxidative stress were significantly reduced by pre­treatment with ursolic acid. Furthermore, ursolic acid significantly suppressed the upregulation of STAT3, NF­κB and caspase­3 activities in rats following I/R­IAKI. These results indicated that ursolic acid may be a potential drug for reducing I/R­IAKI through suppression of inflammation and oxidative stress damage, as well as modulation of STAT3 and NF­κB activities. [Mh] Termos MeSH primário: Lesão Renal Aguda/tratamento farmacológico Anti-Inflamatórios/uso terapêutico Inflamação/tratamento farmacológico Rim/efeitos dos fármacos NF-kappa B/imunologia Traumatismo por Reperfusão/tratamento farmacológico Fator de Transcrição STAT3/imunologia Triterpenos/uso terapêutico [Mh] Termos MeSH secundário: Lesão Renal Aguda/complicações Lesão Renal Aguda/imunologia Lesão Renal Aguda/patologia Animais Anti-Inflamatórios/química Antioxidantes/química Antioxidantes/uso terapêutico Inflamação/complicações Inflamação/imunologia Inflamação/patologia Rim/imunologia Rim/patologia Masculino Estresse Oxidativo/efeitos dos fármacos Prunella/química Ratos Ratos Sprague-Dawley Traumatismo por Reperfusão/complicações Traumatismo por Reperfusão/imunologia Traumatismo por Reperfusão/patologia Triterpenos/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (NF-kappa B); 0 (STAT3 Transcription Factor); 0 (Triterpenes); P3M2575F3F (ursolic acid) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170417 [Lr] Data última revisão: 170417 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160831 [St] Status: MEDLINE [do] DOI: 10.3892/mmr.2016.5654

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[PMID]: 27566209 [Au] Autor: Du D; Lu Y; Cheng Z; Chen D [Ad] Endereço: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China. [Ti] Título: Structure characterization of two novel polysaccharides isolated from the spikes of Prunella vulgaris and their anticomplement activities. [So] Source: J Ethnopharmacol;193:345-353, 2016 Dec 04. [Is] ISSN: 1872-7573 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: ETHNOPHARMACOLOGICAL RELEVANCE: The spikes of Prunella vulgaris have long been used as a traditional Chinese medicine to treat various inflammation-related diseases. The aim of this study was to isolate and characterize homogenous polysaccharides from this herb and to evaluate their anticomplement activity. MATERIALS AND METHODS: Anticomplement activity-guided fractionation of the hot water extract of P. vulgaris was performed by DEAE-cellulose and size-exclusion chromatography, yielding two homogeneous polysaccharides PW-PS1 and PW-PS2. The homogeneity, molecular weight, monosaccharide composition and linkage of the two polysaccharides were determined in addition to other chemical characterizations. The anticomplement activity of the polysaccharides was evaluated and expressed as 50% hemolytic inhibition concentration through the classical pathway (CH value) and alternative pathway (AP value). The preliminary mechanism for the complement activation cascade was also assessed. RESULTS: PW-PS1 and PW-PS2 were both branched acidic polysaccharides. PW-PS1 was composed of Ara, Xyl, and 4-methoxy-Glc A in a ratio of 1.0: 2.6: 0.8. The main linkages of the sugar residues of PW-PS1 included terminal ß-d-Xylp, 1,4-linked ß-d-Xylp, 1,3-linked α-d-Arap, 1,3,5-linked α-d-Arap, and terminal 4-methoxy-α-d-Glcp A. PW-PS2 was composed of Rha, Ara, Xyl, Gal, and Gal A in a ratio of 0.6: 1.0: 1.3: 1.8: 3.4. The main linkages between the sugar residues of PW-PS2 included terminal Araf, 1,4-linked ß-d-Xylp, 1,3-linked α-d-Rhap, terminal α-d-Galp, and 1,4,6-linked α-d-Galp. PW-PS1 and PW-PS2 inhibited complement activation through both the classical and alternative pathways with CH values of 0.28 and 0.13mg/mL, respectively, and AP values of 0.40 and 0.35mg/mL, respectively. Preliminary mechanism studies using complement component-depleted sera showed that PW-PS1 acted on the C1q, C3, and C9 components and that PW-PS2 acted on the C1q, C2, C3, C5, and C9 components. CONCLUSION: Our study suggested that PW-PS1 and PW-PS2 could be valuable for the treatment of diseases associated with the excessive activation of the complement system. [Mh] Termos MeSH primário: Proteínas do Sistema Complemento Componentes Aéreos da Planta/química Polissacarídeos/química Polissacarídeos/farmacologia Prunella/química [Mh] Termos MeSH secundário: Animais Configuração de Carboidratos Cromatografia em Gel Cobaias Coelhos Espectrofotometria Infravermelho Espectrofotometria Ultravioleta [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Polysaccharides); 9007-36-7 (Complement System Proteins) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170531 [Lr] Data última revisão: 170531 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160828 [St] Status: MEDLINE

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[PMID]: 27478103 [Au] Autor: Yang J; Hu YJ; Yu BY; Qi J [Ad] Endereço: Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, China. [Ti] Título: Integrating qualitative and quantitative characterization of Prunellae Spica by HPLC-QTOF/MS and HPLC-ELSD. [So] Source: Chin J Nat Med;14(5):391-400, 2016 May. [Is] ISSN: 1875-5364 [Cp] País de publicação: China [La] Idioma: eng [Ab] Resumo: The present study was designed to analyze the major constituents in Prunellae Spica and establish a method for simultaneous determination of two constituents contained in Prunellae Spica. High performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-QTOF-MS/MS) technique was used to identify the constituents in the extractive of Prunellae Spica. High performance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD) was used to simultaneously quantify two kinds of constituents contained in Prunellae Spica. Principal component analysis (PCA) was applied to compare the similarity and difference among samples from different regions of China. In the present study, 22 compounds were identified and some new fragmental pathways of triterpenic acids were discovered. An accurate and reliable HPLC-ELSD method was developed and validated for the first time to simultaneously quantify multiple constituents, including rosmarinic acid, maslinic acid, corosolic acid, betulin, oleanolic acid, and ursolic acid in the extract of Prunellae Spica. (PCA) revealed some similarities and differences among different samples from different regions of China. In conclusion, our results from this study would be helpful in establishing a scientific and rational quality control method for Prunellae Spica. [Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos Medicamentos de Ervas Chinesas/química Prunella/química Espectrometria de Massas em Tandem/métodos [Mh] Termos MeSH secundário: China Cinamatos/química Depsídeos/química Estrutura Molecular Triterpenos/química [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cinnamates); 0 (Depsides); 0 (Drugs, Chinese Herbal); 0 (Triterpenes); AMX2I57A98 (corosolic acid); E233J88OHQ (maslinic acid); MQE6XG29YI (rosmarinic acid) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160802 [St] Status: MEDLINE

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[PMID]: 27287999 [Au] Autor: Fazal H; Abbasi BH; Ahmad N; Ali M [Ad] Endereço: Department of Plant Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan. [Ti] Título: Elicitation of Medicinally Important Antioxidant Secondary Metabolites with Silver and Gold Nanoparticles in Callus Cultures of Prunella vulgaris L. [So] Source: Appl Biochem Biotechnol;180(6):1076-1092, 2016 Nov. [Is] ISSN: 1559-0291 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Prunella vulgaris L. (P. vulgaris) is an important medicinal plant with a wide range of antiviral properties. Traditionally, it is known as self-heal because of its faster effects on wound healing. It is commonly known as a natural antiseptic due to the presence of various polyphenols. There is lack of research efforts on its propagation and production of bioactive compounds under field and in vitro conditions. In this study, the effects of different ratios (1:2, 1:3, 2:1, and 3:1) of silver (Ag) and gold (Au) nanoparticles (NPs) alone or in combination with naphthalene acetic acid (NAA) were investigated for callus culture development and production of secondary metabolites. The Ag (30 µg l ), AgAu (1:2), and AgAu (2:1) NPs in combination with NAA (2.0 mg l ) enhanced callus proliferation (100 %) as compared to the control (95 %). Among the different NPs tested, AuNPs with or without NAA produced higher biomass in log phases (35-42 days) of growth kinetics. Furthermore, AgAu (1:3) and AuNPs alone enhanced total protein content (855 µg-BSAE/mg-fresh weight (FW)), superoxide dismutase (0.54 nM/min/mg-FW), and peroxidase (0.39 nM/min/mg-FW) enzymes in callus cultures. The AgAuNPs (1:3) in combination with NAA induced maximum accumulation of phenolics (TPC 9.57 mg/g-dry weight (DW)) and flavonoid (6.71 mg/g-DW) content. Moreover, AgAuNPs (3:1) without NAA enhanced antioxidant activity (87.85 %). This study provides the first evidence of NP effect on callus culture development and production of natural antioxidants in P. vulgaris. [Mh] Termos MeSH primário: Antioxidantes/metabolismo Ouro/química Nanopartículas Metálicas/química Plantas Medicinais/crescimento & desenvolvimento Prunella/crescimento & desenvolvimento Metabolismo Secundário Prata/química Técnicas de Cultura de Tecidos/métodos [Mh] Termos MeSH secundário: Biomassa Proliferação Celular Flavonoides/análise Cinética Ácidos Naftalenoacéticos/farmacologia Fenóis/análise Proteínas de Plantas/análise Plantas Medicinais/efeitos dos fármacos Plantas Medicinais/metabolismo Prunella/efeitos dos fármacos Prunella/metabolismo Metabolismo Secundário/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Flavonoids); 0 (Naphthaleneacetic Acids); 0 (Phenols); 0 (Plant Proteins); 3M4G523W1G (Silver); 7440-57-5 (Gold) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170113 [Lr] Data última revisão: 170113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160612 [St] Status: MEDLINE

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[PMID]: 27283235 [Au] Autor: Li C; Huang Q; Xiao J; Fu X; You L; Liu RH [Ad] Endereço: School of Food Science and Technology, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China. [Ti] Título: Preparation of Prunella vulgaris polysaccharide-zinc complex and its antiproliferative activity in HepG2 cells. [So] Source: Int J Biol Macromol;91:671-9, 2016 Oct. [Is] ISSN: 1879-0003 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Prunella vulgaris polysaccharides have been reported to have antioxidant, antitumor and immunomodulatory activities. In this study, P. vulgaris polysaccharide (P1)-zinc complex (P1-Zn) was first prepared by a facile method and its antiproliferative effect on HepG2 human hepatocellular carcinoma cells was also investigated. Results showed that P1-Zn could effectively inhibit the proliferation (98.4% inhibition rate at 500µg/mL) of HepG2 cells through induction of apoptosis, evidenced by morphological changes, chromatin condensation and G0/G1 phase cell cycle arrest. The intracellular mechanism of P1-Zn induced apoptosis was found to be the involvement of the activation of caspase-3 and -9, reactive oxygen species (ROS) overproduction and mitochondrial dysfunction. Our findings suggest that P1-Zn may be a potent candidate for human hepatocellular carcinoma treatment and prevention in functional foods and pharmacological fields. [Mh] Termos MeSH primário: Polissacarídeos/farmacologia Prunella/química Zinco/farmacologia [Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos Caspase 3/metabolismo Caspase 9/metabolismo Pontos de Checagem do Ciclo Celular/efeitos dos fármacos Núcleo Celular/efeitos dos fármacos Núcleo Celular/metabolismo Proliferação Celular/efeitos dos fármacos Forma Celular/efeitos dos fármacos Condutividade Elétrica Células Hep G2 Seres Humanos Potencial da Membrana Mitocondrial/efeitos dos fármacos Espécies Reativas de Oxigênio/metabolismo Espectroscopia de Infravermelho com Transformada de Fourier [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Polysaccharides); 0 (Reactive Oxygen Species); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 9); J41CSQ7QDS (Zinc) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170306 [Lr] Data última revisão: 170306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160611 [St] Status: MEDLINE

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[PMID]: 27222069 [Au] Autor: Su YC; Lin IH; Siao YM; Liu CJ; Yeh CC [Ad] Endereço: * Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Tzu Chi Medical Foundation, Chia-Yi, Taiwan. [Ti] Título: Modulation of the Tumor Metastatic Microenvironment and Multiple Signal Pathways by Prunella vulgaris in Human Hepatocellular Carcinoma. [So] Source: Am J Chin Med;44(4):835-49, 2016. [Is] ISSN: 0192-415X [Cp] País de publicação: Singapore [La] Idioma: eng [Ab] Resumo: Prunella vulgaris (PV) is a traditional Chinese medicine that has been used clinically for centuries in Asian countries to treat herpetic keratitis. In previous studies, PV was shown to suppress TPA-induced activation of MMP-9 and inhibit cell invasion and migration in hepatoma cell lines. However, the detailed molecular mechanism underlying these effects is still unclear. In this study, we investigated the mechanisms underlying PV-mediated inhibition of 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced cell invasion and inhibition of secreted and cytosolic MMP-9 production in human hepatoma cells (Huh-7 and HA22T). PV suppressed VEGF and MMP-9 transcription by inhibiting activator protein (AP)-1 and nuclear factor-[Formula: see text]B (NF-[Formula: see text]B) activity. PV suppressed TPA-induced AP-1 activity by inhibiting phosphorylation of the extracellular signal-related kinase (ERK), downregulating p38 signaling pathways, and suppressing TPA-induced inhibition of NF-[Formula: see text]B nuclear translocation through I[Formula: see text]B. PV suppressed TPA-induced activation of ERK/phosphatidylinositol-3-kinase/Akt upstream of NF-[Formula: see text]B and AP-1. These data suggest that PV modifies the metastatic microenvironment of hepatocellular carcinoma (HCC) by inhibiting multiple signal transduction pathways. PV thus may have the therapeutic potential to inhibit the migration and invasion of HCC and act as potential agent for systemic therapies. [Mh] Termos MeSH primário: Carcinoma Hepatocelular/tratamento farmacológico Medicamentos de Ervas Chinesas/farmacologia Neoplasias Hepáticas/tratamento farmacológico Prunella/química Transdução de Sinais/efeitos dos fármacos Microambiente Tumoral/efeitos dos fármacos [Mh] Termos MeSH secundário: Carcinoma Hepatocelular/genética Carcinoma Hepatocelular/metabolismo Linhagem Celular Tumoral Seres Humanos Neoplasias Hepáticas/genética Neoplasias Hepáticas/metabolismo Metaloproteinase 9 da Matriz/genética Metaloproteinase 9 da Matriz/metabolismo NF-kappa B/genética NF-kappa B/metabolismo Fosforilação/efeitos dos fármacos Fator de Transcrição AP-1/genética Fator de Transcrição AP-1/metabolismo Proteínas Quinases p38 Ativadas por Mitógeno/genética Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drugs, Chinese Herbal); 0 (NF-kappa B); 0 (Transcription Factor AP-1); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 3.4.24.35 (Matrix Metalloproteinase 9) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170117 [Lr] Data última revisão: 170117 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160526 [St] Status: MEDLINE [do] DOI: 10.1142/S0192415X16500464

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[PMID]: 26996013 [Au] Autor: Choia HG; Kim TH; Kim SH; Kim JA [Ti] Título: Anti-allergic Inflammatory Triterpenoids Isolated from the Spikes of Prunella vulgaris. [So] Source: Nat Prod Commun;11(1):31-2, 2016 Jan. [Is] ISSN: 1934-578X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Twelve known triterpenoids (1-12) and two steroids (13 and 14) have been isolated from the spike of the plant Prunella vulgaris. Among them, 2α,3α,23-trihydroxyursa-12,20(30)-dien-28-oic acid (10) was isolated for the first time from this plant. All isolates were evaluated for their inhibitory effect on the gene expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and release of histamine in human mast cells. ß-Amyrin (5), 10, and euscaphic acid (12) showed suppression of histamine release with percentage inhibitions of 46.7, 57.9, and 54.2%, respectively. In addition, 5 and 10 showed strong inhibition of TNF-α and IL-6 in the test for pro-inflammatory cytokines. Our results suggest that compounds 5 and 10 largely contribute to the anti-allergic inflammatory effect of P. vulgaris. [Mh] Termos MeSH primário: Antialérgicos/farmacologia Anti-Inflamatórios/farmacologia Citocinas/metabolismo Regulação da Expressão Gênica/efeitos dos fármacos Prunella/química Triterpenos/farmacologia [Mh] Termos MeSH secundário: Antialérgicos/química Anti-Inflamatórios/química Citocinas/genética Histamina/metabolismo Seres Humanos Mastócitos/efeitos dos fármacos Mastócitos/metabolismo Fitoterapia Triterpenos/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Anti-Allergic Agents); 0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Triterpenes); 820484N8I3 (Histamine) [Em] Mês de entrada: 1605 [Cu] Atualização por classe: 160321 [Lr] Data última revisão: 160321 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160322 [St] Status: MEDLINE

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