Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.583.520.922.770 [Categoria DeCS] Referências encontradas : 265 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 29222859 [Au] Autor: Tyliszczak B; Drabczyk A; Kudlacik-Kramarczyk S; Grabowska B; Kedzierska M [Ad] Endereço: Department of Chemistry and Technology of Polymers, Cracow University of Technology, Kraków, Poland. [Ti] Título: Physicochemical properties and cytotoxicity of hydrogels based on Beetosan® containing sage and bee pollen. [So] Source: Acta Biochim Pol;64(4):709-712, 2017. [Is] ISSN: 1734-154X [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: Currently, increasing attention is being paid to issues related to environmental protection, waste management, as well as to the development of polymers with useful properties. The research presented here involved preparation of hydrogels based on Beetosan® - a chitosan derived from the multi-stage processing of dead bees. Moreover, hydrogels were additionally modified with natural substances - i.e. bee pollen and extract of Salvia officinalis (sage) that are well known for the presence of many compounds with beneficial properties from a medical point of view. Materials have been first obtained by photopolymerization. Then, their surface morphology, wettability and cytotoxicity to selected cell lines have been determined. It can be stated that such combination of Beetosan® hydrogel matrix and the mentioned additives resulted in a preparation of polymers characterized by negative impact on cancer cells. Impact of hydrogels with sage is slightly more intense due to the presence of substances such as ursalic or rosmaric acid that are characterized to have anticancer activity. Such negative impact has not been observed in case of studies using fibroblasts. Furthermore, addition of natural substances into hydrogels resulted in a more homogeneous surface and in the decrease of wettability angle of the tested polymers. It can be concluded that the use of natural-derived reagents and synthesis of polymers using these reagents (as a result of environmentally friendly photopolymerization) yields materials with interesting properties for medical purposes, with particular emphasis on antitumor activity, and without significant negative impact on fibroblasts. [Mh] Termos MeSH primário: Hidrogéis/química Hidrogéis/toxicidade Pólen/química [Mh] Termos MeSH secundário: Animais Abelhas Quitosana/química Seres Humanos Células Jurkat Microscopia Eletrônica de Varredura Salvia officinalis Testes de Toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hydrogels); 9012-76-4 (Chitosan) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171210 [St] Status: MEDLINE [do] DOI: 10.18388/abp.2017_2319

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[PMID]: 28668297 [Au] Autor: Flampouri E; Sotiropoulou ΝD; Mavrikou S; Mouzaki-Paxinou AC; Tarantilis PA; Kintzios S [Ad] Endereço: Laboratory of Cell Technology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece. Electronic address: flampouri_kel@aua.gr. [Ti] Título: Conductive polymer-based bioelectrochemical assembly for in vitro cytotoxicity evaluation: Renoprotective assessment of Salvia officinalis against carbon tetrachloride induced nephrotoxicity. [So] Source: Biochim Biophys Acta;1861(9):2304-2314, 2017 09. [Is] ISSN: 0006-3002 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: BACKGROUND: The rise of organic electronics represents one of the most prominent technological developments of the last two decades, with its interface with biological systems highlighting new directions of research. The "soft" nature of conducting polymers renders them unique platforms for cell-based microdevices, allowing their implementation in drug discovery, pharmaceutical effect analysis, environmental pollutant testing etc. METHODS: Cellular adhesion, proliferation and viability experiments were carried out to verify the biocompatibility of a PEDOT conductive polymer surface. Cyclic voltammetry was employed for estimating the electrocatalytic activity of the renal cell/electrode interface. The nephrotoxicity agent CCl and the medicinal plant Salvia officinalis were used on the proposed assembly. Renal cell viability was also assayed through the MTT assay. RESULTS: Renal cells were able to adhere and proliferate on the conducting polymer surface. Electrochemical responses of the polymer exhibited good correlation with cell number and CCl concentration. Amelioration of the CCl -induced renotoxicity by co-incubation with Salvia officinalis extract was demonstrated by both the MTT assay and the electrode's capacitance. CONCLUSIONS: A conducting polymer-based bioelectrochemical assembly was established for in vitro mammalian cytotoxicity/cytoprotection assessment, employing renal cell monolayers as the primary transducers for signal generation and biological sensing. GENERAL SIGNIFICANCE: The knowledge on PEDOT mammalian cell biocompatibility and possible applications was expanded. The proposed interdisciplinary approach connects soft electronics with biology and could provide a useful tool for preliminary crude drug screening and bioactivity studies of natural products or plant extracts in vitro. [Mh] Termos MeSH primário: Avaliação Pré-Clínica de Medicamentos/métodos Rim/efeitos dos fármacos Extratos Vegetais/farmacologia Salvia officinalis [Mh] Termos MeSH secundário: Animais Tetracloreto de Carbono/toxicidade Proliferação Celular/efeitos dos fármacos Sobrevivência Celular/efeitos dos fármacos Cercopithecus aethiops Eletroquímica Polímeros Células Vero [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Plant Extracts); 0 (Polymers); CL2T97X0V0 (Carbon Tetrachloride) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171108 [Lr] Data última revisão: 171108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170703 [St] Status: MEDLINE

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[PMID]: 28550743 [Au] Autor: Radwan A; Kleinwächter M; Selmar D [Ad] Endereço: Technische Universität Braunschweig, Institute for Plant Biology, Mendelssohnstr. 4, 38106, Braunschweig, Germany; Agriculture Genetic Engineering Research Institute, AGERI, ARC, Giza, Egypt. [Ti] Título: Impact of drought stress on specialised metabolism: Biosynthesis and the expression of monoterpene synthases in sage (Salvia officinalis). [So] Source: Phytochemistry;141:20-26, 2017 Sep. [Is] ISSN: 1873-3700 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: In previous experiments, we demonstrated that the amount of monoterpenes in sage is increased massively by drought stress. Our current study is aimed to elucidate whether this increase is due, at least in part, to elevated activity of the monoterpene synthases responsible for the biosynthesis of essential oils in sage. Accordingly, the transcription rates of the monoterpene synthases were analyzed. Salvia officinalis plants were cultivated under moderate drought stress. The concentrations of monoterpenes as well as the expression of the monoterpene synthases were analyzed. The amount of monoterpenes massively increased in response to drought stress; it doubled after just two days of drought stress. The observed changes in monoterpene content mostly match with the patterns of monoterpene synthase expressions. The expression of bornyl diphosphate synthase was strongly up-regulated; its maximum level was reached after two days. Sabinene synthase increased gradually and reached a maximum after two weeks. In contrast, the transcript level of cineole synthase continuously declined. This study revealed that the stress related increase of biosynthesis is not only due to a "passive" shift caused by the stress related over-reduced status, but also is due - at least in part-to an "active" up-regulation of the enzymes involved. [Mh] Termos MeSH primário: Secas Liases Intramoleculares/metabolismo Salvia officinalis/enzimologia Estresse Fisiológico [Mh] Termos MeSH secundário: Regulação da Expressão Gênica de Plantas Liases Intramoleculares/genética Monoterpenos/metabolismo Óleos Voláteis/metabolismo Salvia officinalis/genética Regulação para Cima [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Monoterpenes); 0 (Oils, Volatile); EC 5.5.- (Intramolecular Lyases); EC 5.5.- (pinene cyclase I); EC 5.5.1.8 (geranyl-diphosphate cyclase) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170721 [Lr] Data última revisão: 170721 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170528 [St] Status: MEDLINE

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[PMID]: 28477412 [Au] Autor: Cutillas AB; Carrasco A; Martinez-Gutierrez R; Tomas V; Tudela J [Ad] Endereço: GENZ-Group of Research on Enzymology (www.um.es/genz), Department of Biochemistry and Molecular Biology-A, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30100, Murcia, Spain. [Ti] Título: Salvia officinalis L. Essential Oils from Spain: Determination of Composition, Antioxidant Capacity, Antienzymatic, and Antimicrobial Bioactivities. [So] Source: Chem Biodivers;14(8), 2017 Aug. [Is] ISSN: 1612-1880 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Four essential oils (EOs) from Salvia officinalis L. cultivated in Spain (Murcia Province) were analyzed by gas chromatography coupled with mass spectrometry (GC/MS) to determine their relative and absolute compositions. The main components were α-thujone (22.8 - 41.7%), camphor (10.7 - 19.8%), 1,8-cineole (4.7 - 15.6%), and ß-thujone (6.1 - 15.6%). Enantioselective gas chromatography identified (-)-α-thujone and (+)-camphor as the main enantiomers in all the analyzed EOs. Furthermore, when the EOs were tested to determine their antioxidant activity against free radicals and as ferric reducing and ferrous chelating agents, all were seen to have moderate activity due to the compounds they contained, such as linalool or terpinene. Because of their known relation with inflammatory illnesses and Alzheimer's disease, respectively, the inhibition of lipoxygenase and acetylcholinesterase was studied using the EOs. Some individual compounds also inhibited these enzymes. In addition, the studied EOs were able to inhibit the growth of Escherichia coli, Staphylococcus aureus, and Candida albicans. The characterization carried out increases our awareness of the possible uses of S. officinalis EO as natural additives in food, cosmetics, and pharmaceuticals. [Mh] Termos MeSH primário: Óleos Voláteis/química Salvia officinalis/química [Mh] Termos MeSH secundário: Acetilcolinesterase/química Acetilcolinesterase/metabolismo Anti-Infecciosos/química Anti-Infecciosos/isolamento & purificação Anti-Infecciosos/farmacologia Antioxidantes/química Candida albicans/efeitos dos fármacos Análise por Conglomerados Cicloexanóis/análise Escherichia coli/efeitos dos fármacos Cromatografia Gasosa-Espectrometria de Massas Concentração Inibidora 50 Lipoxigenase/química Lipoxigenase/metabolismo Monoterpenos/análise Óleos Voláteis/análise Óleos Voláteis/metabolismo Análise de Componente Principal Ligação Proteica Salvia officinalis/metabolismo Espanha Staphylococcus aureus/efeitos dos fármacos Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Cyclohexanols); 0 (Monoterpenes); 0 (Oils, Volatile); 8ZI5R3T54Q (beta-thujone); D81QY6I88E (linalool); EC 1.13.11.12 (Lipoxygenase); EC 3.1.1.7 (Acetylcholinesterase); RV6J6604TK (eucalyptol) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170507 [St] Status: MEDLINE [do] DOI: 10.1002/cbdv.201700102

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[PMID]: 28472675 [Au] Autor: Radulovic NS; Gencic MS; Stojanovic NM; Randjelovic PJ; Stojanovic-Radic ZZ; Stojiljkovic NI [Ad] Endereço: Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia. Electronic address: nikoradulovic@yahoo.com. [Ti] Título: Toxic essential oils. Part V: Behaviour modulating and toxic properties of thujones and thujone-containing essential oils of Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L. [So] Source: Food Chem Toxicol;105:355-369, 2017 Jul. [Is] ISSN: 1873-6351 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Neurotoxic thujones (α- and ß-diastereoisomers) are common constituents of plant essential oils. In this study, we employed a statistical approach to determine the contribution of thujones to the overall observed behaviour-modulating and toxic effects of essential oils (Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.) containing these monoterpene ketones. The data from three in vivo neuropharmacological tests on rats (open field, light-dark, and diazepam-induced sleep), and toxicity assays (brine shrimp, and antimicrobial activity against a panel of microorganisms), together with the data from detailed chemical analyses, were subjected to a multivariate statistical treatment to reveal the possible correlation(s) between the content of essential-oil constituents and the observed effects. The results strongly imply that the toxic and behaviour-modulating activity of the oils (hundreds of constituents) should not be associated exclusively with thujones. The statistical analyses pinpointed to a number of essential-oil constituents other than thujones that demonstrated a clear correlation with either the toxicity, antimicrobial effect or the activity on CNS. Thus, in addition to the thujone content, the amount and toxicity of other constituents should be taken into consideration when making risk assessment and determining the regulatory status of plants in food and medicines. [Mh] Termos MeSH primário: Artemisia absinthium/química Óleos Voláteis/toxicidade Óleos Vegetais/toxicidade Salvia officinalis/química Tanacetum/química Thuja/química [Mh] Termos MeSH secundário: Animais Artemisia absinthium/toxicidade Cromatografia Gasosa-Espectrometria de Massas Masculino Óleos Voláteis/análise Óleos Vegetais/análise Ratos Ratos Wistar Salvia officinalis/toxicidade Tanacetum/toxicidade Thuja/toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Oils, Volatile); 0 (Plant Oils) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170906 [Lr] Data última revisão: 170906 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE

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[PMID]: 28190677 [Au] Autor: Despinasse Y; Fiorucci S; Antonczak S; Moja S; Bony A; Nicolè F; Baudino S; Magnard JL; Jullien F [Ad] Endereço: Université de Lyon, F-42023, Saint-Etienne, France; Université de Saint-Etienne, Jean Monnet, F-42000, Saint-Etienne, France; Laboratoire de Biotechnologies Végétales Appliquées aux Plantes Aromatiques et Médicinales, EA 3061, 23 Rue du Dr Michelon, F-42000, Saint-Etienne, France. [Ti] Título: Bornyl-diphosphate synthase from Lavandula angustifolia: A major monoterpene synthase involved in essential oil quality. [So] Source: Phytochemistry;137:24-33, 2017 May. [Is] ISSN: 1873-3700 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Lavender essential oils (EOs) of higher quality are produced by a few Lavandula angustifolia cultivars and mainly used in the perfume industry. Undesirable compounds such as camphor and borneol are also synthesized by lavender leading to a depreciated EO. Here, we report the cloning of bornyl diphosphate synthase of lavender (LaBPPS), an enzyme that catalyzes the production of bornyl diphosphate (BPP) and then by-products such as borneol or camphor, from an EST library. Compared to the BPPS of Salvia officinalis, the functional characterization of LaBPPS showed several differences in amino acid sequence, and the distribution of catalyzed products. Molecular modeling of the enzyme's active site suggests that the carbocation intermediates are more stable in LaBPPS than in SoBPPS leading probably to a lower efficiency of LaBPPS to convert GPP into BPP. Quantitative RT-PCR performed from leaves and flowers at different development stages of L. angustifolia samples show a clear correlation between transcript level of LaBPPS and accumulation of borneol/camphor, suggesting that LaBPPS is mainly responsible of in vivo biosynthesis of borneol/camphor in fine lavender. A phylogenetic analysis of terpene synthases (TPS) pointed out the basal position of LaBPPS in the TPSb clade, suggesting that LaBPPS could be an ancestor of others lavender TPSb. Finally, borneol could be one of the first monoterpenes to be synthesized in the Lavandula subgenus. Knowledge gained from these experiments will facilitate future studies to improve the lavender oils through metabolic engineering or plant breeding. Accession numbers: LaBPPS: KM015221. [Mh] Termos MeSH primário: Liases Intramoleculares/metabolismo Lavandula/enzimologia Óleos Voláteis/química Óleos Vegetais/química Proteínas de Plantas/metabolismo [Mh] Termos MeSH secundário: Alquil e Aril Transferases/genética Alquil e Aril Transferases/metabolismo Sequência de Aminoácidos Bornanos/química Cânfora/química Domínio Catalítico Clonagem Molecular Flores/enzimologia Liases Intramoleculares/genética Modelos Moleculares Filogenia Folhas de Planta/enzimologia Proteínas de Plantas/genética Salvia officinalis/enzimologia Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Bornanes); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Plant Proteins); 76-22-2 (Camphor); EC 2.5.- (Alkyl and Aryl Transferases); EC 2.5.1.- (terpene synthase); EC 5.5.- (Intramolecular Lyases); EC 5.5.- (pinene cyclase I); EC 5.5.1.8 (geranyl-diphosphate cyclase); ZBP1YXW0H8 (lavender oil) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170407 [Lr] Data última revisão: 170407 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170214 [St] Status: MEDLINE

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[PMID]: 28041562 [Au] Autor: Li Y; Liu H; Han Q; Kong B; Liu Q [Ad] Endereço: College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. [Ti] Título: Cooperative antioxidative effects of zein hydrolysates with sage (Salvia officinalis) extract in a liposome system. [So] Source: Food Chem;222:74-83, 2017 May 01. [Is] ISSN: 0308-8146 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: This study investigated the cooperative antioxidative effects of sage extract (SE) and zein hydrolysates (ZH). The combination of 3mg/ml ZH and 10µg/ml SE exhibited a significant synergism in inhibition of the formation of thiobarbituric acid-reactive substances and provided superior protection of liposomes against oxidation. Zeta-potential results revealed that the interactions between liposomes and ZH were electrostatic interactions. Particle size determination further proved that ZH and SE added to oxidized liposomes significantly decreased the mean particle size. Confocal laser scanning microscopy revealed that when ZH was present in the liposome oxidizing system, the droplet sizes were obviously decreased compared to oxidized samples. ZH dispersed more uniformly and the interfacial membrane was more compact in the ZH-SE liposome. Transmission electron microscopy conveyed that the ZH-SE complex around the liposome particles could form a denser network structure, preventing radicals and oxidants from the approach of the liposomes. [Mh] Termos MeSH primário: Antioxidantes/farmacologia Lipossomos/química Extratos Vegetais/farmacologia Salvia officinalis Zeína/farmacologia [Mh] Termos MeSH secundário: Lipídeos/química Lipossomos/ultraestrutura Zeína/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Lipids); 0 (Liposomes); 0 (Plant Extracts); 9010-66-6 (Zein) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170103 [St] Status: MEDLINE

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[PMID]: 27930987 [Au] Autor: Jiang Y; Zhang L; Rupasinghe HP [Ad] Endereço: College of Science, Sichuan Agricultural University, Yaan 625014, Sichuan, China; Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia B2N 5E3, Canada. [Ti] Título: Antiproliferative effects of extracts from Salvia officinalis L. and Saliva miltiorrhiza Bunge on hepatocellular carcinoma cells. [So] Source: Biomed Pharmacother;85:57-67, 2017 Jan. [Is] ISSN: 1950-6007 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: Salvia species have been used as valuable medicinal and herbal plant in many countries. Salvia officinalis L. and Salvia miltiorrhiza Bunge are widely used in traditional medicine for a long time. In the present study, cytotoxicity of ethanol and acetone extracts prepared from leaves and roots of two Salvia species was investigated using hepatocellular carcinoma cells (HepG2) and normal human liver cells (WRL-68). The cytotoxicity and anti-proliferative abilities of the extracts were evaluated by measuring cell viability (MTS assay), lactate dehydrogenase (LDH) leakage, the cellular ATP level, morphological changes using an inverted microscope, and apoptosis using flow cytometry. The results indicated that ethanol and acetone extracts of leaves and roots of S. officinalis (SO-L-E, SO-L-A, SO-R-E and SO-R-A, respectively) and ethanol and acetone extracts of roots of S. miltiorrhiza (SM-R-E and SM-R-A, respectively) significantly inhibited the proliferation of HepG2 cells in a time- and dose-dependent manner when the concentration was less than 150µg/mL. The cytotoxity of SO-L-E, SO-R-E and SO-R-A were significantly less in WRL-68 when compared to HepG2 cells in vitro. The increase of LDH leakage, decrease of ATP and the changes in morphology of HepG2 cells further confirmed the cytotoxic effect of these extracts to HepG2 cells. Furthermore, SO-L-E, SO-L-A, SO-R-E ethanol extract of leaves of S. miltiorrhiza (SM-L-E) and SM-R-E were able to induce apoptosis in HepG2 cells. This study shows the potential of the extracts to be used in the prevention and/or treatment of liver cancer or as ingredients in functional foods and provides scientific support for development and utilization of S. officinalis and S. miltiorrhiza, especially the roots of S. officinalis. [Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos Hepatócitos/efeitos dos fármacos Extratos Vegetais/farmacologia Salvia miltiorrhiza/química Salvia officinalis/química [Mh] Termos MeSH secundário: Carcinoma Hepatocelular/tratamento farmacológico Sobrevivência Celular Células Hep G2 Seres Humanos Neoplasias Hepáticas/tratamento farmacológico Fitoterapia Extratos Vegetais/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Extracts) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170222 [Lr] Data última revisão: 170222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161209 [St] Status: MEDLINE

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[PMID]: 27888449 [Au] Autor: Lopresti AL [Ad] Endereço: School of Psychology and Exercise Science, Murdoch University, Perth, WA, 6150, Australia. a.lopresti@murdoch.edu.au. [Ti] Título: Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects. [So] Source: Drugs R D;17(1):53-64, 2017 Mar. [Is] ISSN: 1179-6901 [Cp] País de publicação: New Zealand [La] Idioma: eng [Ab] Resumo: Genus Salvia, commonly known as sage, is the largest genus in the Lamiaceae family. It comprises many species traditionally used as brain-enhancing tonics. In vitro and animal studies have confirmed that several Salvia species contain a large array of active compounds that may enhance cognitive activity and protect against neurodegenerative disease. In this review, the active constituents in plants belonging to the genus Salvia are summarised, and their influence on pharmacodynamics pertinent to cognitive activity are detailed. In particular, the effects of plants belonging to the genus Salvia and their constituents on cognitive skills including memory, attention and learning are detailed. Their potential effects in dementia, including Alzheimer's disease, are also examined. Completed human trials are summarised, and factors influencing the potency of Salvia plants are covered. Finally, directions for future research are proposed to enhance our understanding of the potential health benefits of Salvia plants. [Mh] Termos MeSH primário: Cognição/efeitos dos fármacos Doenças Neurodegenerativas/tratamento farmacológico Doenças Neurodegenerativas/prevenção & controle Fármacos Neuroprotetores/farmacologia Nootrópicos/farmacologia Extratos Vegetais/uso terapêutico Salvia officinalis/química [Mh] Termos MeSH secundário: Animais Seres Humanos Fármacos Neuroprotetores/química Fármacos Neuroprotetores/uso terapêutico Nootrópicos/uso terapêutico Extratos Vegetais/química Extratos Vegetais/farmacologia Plantas Medicinais/química [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Neuroprotective Agents); 0 (Nootropic Agents); 0 (Plant Extracts) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170503 [Lr] Data última revisão: 170503 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161127 [St] Status: MEDLINE [do] DOI: 10.1007/s40268-016-0157-5

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[PMID]: 27765212 [Au] Autor: Binsi PK; Nayak N; Sarkar PC; Jeyakumari A; Muhamed Ashraf P; Ninan G; Ravishankar CN [Ad] Endereço: ICAR-Central Institute of Fisheries Technology (CIFT), Matsyapuri, Willington Island, Cochin 682 029, India. Electronic address: binsipk@yahoo.com. [Ti] Título: Structural and oxidative stabilization of spray dried fish oil microencapsulates with gum arabic and sage polyphenols: Characterization and release kinetics. [So] Source: Food Chem;219:158-168, 2017 Mar 15. [Is] ISSN: 0308-8146 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The synergistic efficacy of gum arabic and sage polyphenols in stabilising capsule wall and protecting fish oil encapsulates from heat induced disruption and oxidative deterioration during spray drying was assessed. The emulsions prepared with sodium caseinate as wall polymer, gum arabic as wall co-polymer and sage extract as wall stabiliser was spray dried using a single fluid nozzle. Fish oil encapsulates stabilised with gum arabic and sage extract (SOE) exhibited significantly higher encapsulation efficiency compared to encapsulates containing gum arabic alone (FOE). Scanning electron microscopic and atomic force microscopic images revealed uniform encapsulates with good sphericity and smooth surface for SOE, compared to FOE powder. In vitro oil release of microencapsulates indicated negligible oil release in buffered saline whereas more than 80% of the oil loaded in encapsulates were released in simulated GI fluids. The encapsulates containing sage extract showed a lower rate of lipid oxidation during storage. [Mh] Termos MeSH primário: Óleos de Peixe/administração & dosagem Salvia officinalis/química [Mh] Termos MeSH secundário: Animais Cápsulas/química Caseínas/química Gorduras Insaturadas na Dieta Estabilidade de Medicamentos Emulsões/química Óleos de Peixe/química Goma Arábica/química Cinética Oxirredução Polifenóis/química Pós/química Espectroscopia de Infravermelho com Transformada de Fourier [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Capsules); 0 (Caseins); 0 (Dietary Fats, Unsaturated); 0 (Emulsions); 0 (Fish Oils); 0 (Polyphenols); 0 (Powders); 9000-01-5 (Gum Arabic) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161022 [St] Status: MEDLINE

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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