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Pesquisa : B01.650.940.800.575.912.250.583.520.942 [Categoria DeCS]
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[PMID]:28957336
[Au] Autor:Sashourpour M; Zahri S; Radjabian T; Ruf V; Pan-Montojo F; Morshedi D
[Ad] Endereço:Department of Biology, Faculty of Science, Mohaghegh Ardabili University, Ardabil, Iran.
[Ti] Título:A study on the modulation of alpha-synuclein fibrillation by Scutellaria pinnatifida extracts and its neuroprotective properties.
[So] Source:PLoS One;12(9):e0184483, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aggregation of alpha-synuclein (α-SN) is a key pathogenic event in Parkinson's disease (PD) leading to dopaminergic degeneration. The identification of natural compounds inhibiting α-SN aggregation may have a major role in treating PD. Different Scutellaria species are known as valuable medicinal plants, primarily due to their high flavonoid levels. Scutellaria pinnatifida (S. pinnatifida) is endemic to Iran; however, the knowledge of its pharmaceutical properties is limited. Here we report that S. pinnatifida extracts have an anti-fibrillation effect on α-SN aggregation and neuroprotective properties on PC12 and primary dopaminergic neurons. Treatment during α-SN fibril formation with S. pinnatifida extracts showed that the extractions performed with dichloromethane (DCMEx) and n-butanol (BuOHEx) strongly inhibited α-SN fibrillation. TLC-based analysis revealed that S. pinnatifida contains a great amount of flavonoids with high antioxidant properties as shown using a radical scavenging assay. Further analysis using HPLC and Mass spectroscopy on the DCMEx revealed the presence of baicalein in this extract. We then selected the more efficient extracts based on cell viability and ROS scavenging on PC12 cells and tested their neuroprotective properties on primary dopaminergic neurons. Our results showed the extracts strongly protected against α-SN oligomers. Surprisingly, they also neutralized the severe toxicity of paraquat. Therefore, S. pinnatifida may be a potential valuable medicinal herb for further studies related to the treatment of PD.
[Mh] Termos MeSH primário: Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
Scutellaria/química
alfa-Sinucleína/toxicidade
[Mh] Termos MeSH secundário: Animais
Morte Celular/efeitos dos fármacos
Neurônios Dopaminérgicos/efeitos dos fármacos
Neurônios Dopaminérgicos/metabolismo
Flavonoides/metabolismo
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Microscopia de Fluorescência
Células PC12
Paraquat/toxicidade
Raízes de Plantas/química
Multimerização Proteica/efeitos dos fármacos
Ratos
alfa-Sinucleína/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (alpha-Synuclein); PLG39H7695 (Paraquat)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184483


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[PMID]:28613371
[Au] Autor:Chen X; Bai J; Li Y; Li XG; Lv GF; Zhang HC
[Ad] Endereço:School of Pharmacy, , , China.
[Ti] Título:Effect of Shenqin biochemical extract on hypoxia-inducible factor-1α expression in ultraviolet B-irradiated HaCaT cells.
[So] Source:Genet Mol Res;16(2), 2017 May 31.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Hypoxia-inducible factor-1α (HIF-1α) is considered the main transcriptional regulator of the hypoxia-specific cellular and developmental response. This study was performed to investigate the effect of Shenqin biochemical extract (SQBE) on HIF-1α expression in ultraviolet B (UVB)-irradiated HaCaT cells and the possible action mechanisms of SQBE against UVB-induced skin cancer. HaCaT cells in logarithmic growth phase were seeded in Dulbecco's modified Eagle's medium with 10% fetal bovine serum, and conventionally cultured at 37°C with 5% CO . Cells were divided into control group (administered the same amounts of dimethyl sulfoxide), SQBE1 group (12.5 µg/mL SQBE), SQBE2 group (25.0 µg/mL SQBE), and SQBE3 group (50.0 µg/mL SQBE). Four hours post administration, the control and treatment groups were irradiated with UVB (0, 20, 40, and 60 mJ/cm ). After 24 h, cell survival rate was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Expression levels of HIF-1α mRNA and protein were detected by polymerase chain reaction and western blotting, respectively. SQBE-treated, UVB-irradiated cells had improved survival rates. This increase was most significant in SQBE3 group (P < 0.01), which also had effectively reduced expression of intracellular HIF-1α mRNA and protein. Hence, SQBE had a protective effect on UVB-irradiated HaCaT cells and inhibited the UVB irradiation-induced expression of HIF-1α. This indicates that SQBE could prevent the occurrence of UVB radiation-induced skin cancer.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Seres Humanos
Subunidade alfa do Fator 1 Induzível por Hipóxia/genética
Queratinócitos/efeitos dos fármacos
Queratinócitos/metabolismo
Queratinócitos/efeitos da radiação
Panax/química
Scutellaria/química
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (HIF1A protein, human); 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16029430


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[PMID]:28351723
[Au] Autor:Yuan QQ; Song WB; Wang WQ; Xuan LJ
[Ad] Endereço:State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China.
[Ti] Título:Scubatines A-F, new cytotoxic neo-clerodane diterpenoids from Scutellaria barbata D. Don.
[So] Source:Fitoterapia;119:40-44, 2017 Jun.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the 70% acetone extract of the whole plant of Scutellaria barbata D. Don afforded six new neo-clerodane diterpenoids, scubatines A-F (1-6), and four known analogues (7-10). Their structures were elucidated on the basis of extensive spectroscopic analyses. Cytotoxic activity against the HL-60 and A549 cell lines was assessed for all isolated compounds. Compound 9 exhibited moderate activity against HL-60 with an IC value of 5.6µM. Compound 6 showed weak cytotoxic activity against A549 and HL-60 with IC values of 10.4 and 15.3µM, respectively.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Diterpenos Clerodânicos/química
Scutellaria/química
[Mh] Termos MeSH secundário: Células A549
Antineoplásicos Fitogênicos/isolamento & purificação
Diterpenos Clerodânicos/isolamento & purificação
Ensaios de Seleção de Medicamentos Antitumorais
Células HL-60
Seres Humanos
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes, Clerodane)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


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[PMID]:28086772
[Au] Autor:Kan X; Zhang W; You R; Niu Y; Guo J; Xue J
[Ad] Endereço:Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
[Ti] Título:Scutellaria barbata D. Don extract inhibits the tumor growth through down-regulating of Treg cells and manipulating Th1/Th17 immune response in hepatoma H22-bearing mice.
[So] Source:BMC Complement Altern Med;17(1):41, 2017 Jan 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous studies showed Scutellaria barbata D. Don extract (SBE) is a potent inhibitor in hepatoma and could improve immune function of hepatoma H22-bearing mice. However, the immunomodulatory function of SBE on the tumor growth of hepatoma remains unclear. This study aimed to investigate the anti-tumor effects of SBE on hepatoma H22-bearing mice and explore the underlying immunomodulatory function. METHODS: The hepatoma H22-bearing mice were treated by SBE for 30 days. The effect of SBE on the proliferation of HepG2 cells in vitro, the growth of transplanted tumor, the cytotoxicity of natural killer (NK) cells in spleen, the amount of CD4 CD25 Foxp3 Treg cells and Th17 cells in tumor tissue, and the levels of IL-10, TGF-ß, IL-17A, IL-2, and IFN-γ in serum of the hepatoma H22-bearing mice was observered. IL-17A was injected to the SBE treated mice from day 9 post H22 inoculation to examine its effect on tumor growth. RESULTS: SBE treatment inhibited the proliferation of HepG2 cells in vitro with a dose-dependent manner and significantly suppressed the tumor growth of hepatoma H22-bearing mice. Meanwhile, it increased NK cells' cytotoxicity in spleen, down-regulated the amount of CD4 CD25 Foxp3 Treg cells and Th17 cells in tumor tissue, and decreased IL-10, TGF-ß, and IL-17A levels (P < 0.01) whereas increased IL-2 and IFN-γ levels (P < 0.01) in the serum of hepatoma H22-bearing mice. Moreover, administration of recombinant mouse IL-17A reversed the anti-tumor effects of SBE. CONCLUSION: SBE could inhibit the proliferation of HepG2 cells in vitro. Meanwhile, SBE also could inhibit the growth of H22 implanted tumor in hepatoma H22-bearing mice, and this function might be associated with immunomodulatory activity through down-regulating of Treg cells and manipulating Th1/Th17 immune response.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Medicamentos de Ervas Chinesas/administração & dosagem
Neoplasias Hepáticas/tratamento farmacológico
Scutellaria/química
Linfócitos T Reguladores/efeitos dos fármacos
Células Th1/efeitos dos fármacos
Células Th17/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Regulação para Baixo/efeitos dos fármacos
Seres Humanos
Interleucina-10/genética
Interleucina-10/imunologia
Interleucina-17/genética
Interleucina-17/imunologia
Células Matadoras Naturais/efeitos dos fármacos
Células Matadoras Naturais/imunologia
Neoplasias Hepáticas/genética
Neoplasias Hepáticas/imunologia
Neoplasias Hepáticas/fisiopatologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Células Th1/imunologia
Células Th17/imunologia
Fator de Crescimento Transformador beta/genética
Fator de Crescimento Transformador beta/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Interleukin-17); 0 (Transforming Growth Factor beta); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1551-9


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[PMID]:28035355
[Au] Autor:Yang N; Zhao Y; Wang Z; Liu Y; Zhang Y
[Ad] Endereço:Department of Oncology, The Affiliated Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
[Ti] Título:Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway.
[So] Source:Mol Med Rep;15(2):929-935, 2017 Feb.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Scutellarin is a flavonoid isolated from a medicinal herb Scutellaria barbata D. Don and exerts therapeutic effects on cardiovascular diseases. However, it remains unclear whether Scutellarin exhibits anti­tumor actions on human colon cancer. The current study aimed to investigate whether Scutellarin produces antiproliferative and pro­apoptotic effects on HCT­116 human colon cancer cells and to elucidate the mechanisms involved. Human colon cancer cells were exposed to different concentrations of Scutellarin, and cellular growth and apoptosis were evaluated by MTT assay, terminal deoxynucleotidyl transferase­mediated dUTP nick end labeling (TUNEL) staining, western blot analysis and other assays. A cell viability assay demonstrated that Scutellarin treatment reduced the viability of HCT­116 cells in a dose­ and time­dependent manner. TUNEL staining demonstrated that Scutellarin also induced apoptotic changes in HCT­116 cells. The expression level of the anti­apoptotic protein, Bcl­2 apoptosis regulator (Bcl­2), was reduced by Scutellarin in HCT­116 cells, whereas the expression Bcl­2 associated X apoptosis regulator (Bax) and the activation of caspase­3 protein were increased by Scutellarin treatment. Further investigation revealed that Scutellarin significantly increased the phosphorylation of p53 protein in HCT­116 cells. Additionally, suppression of p53 using a specific inhibitor, pifithrin­α, abrogated the pro­apoptotic effects of Scutellarin in HCT­116 cells. Collectively, Scutellarin reduced the viability and induced apoptosis of human colon carcinoma cells, potentially by regulating p53 and Bcl­2/Bax expression. These data suggested that Scutellarin may be useful as a promising anti­tumor drug for treating colon cancer.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apigenina/farmacologia
Apoptose/efeitos dos fármacos
Neoplasias Colorretais/tratamento farmacológico
Glucuronatos/farmacologia
Transdução de Sinais/efeitos dos fármacos
Proteína Supressora de Tumor p53/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Apigenina/química
Proliferação Celular/efeitos dos fármacos
Colo/efeitos dos fármacos
Colo/metabolismo
Colo/patologia
Neoplasias Colorretais/metabolismo
Neoplasias Colorretais/patologia
Glucuronatos/química
Células HCT116
Seres Humanos
Reto/efeitos dos fármacos
Reto/metabolismo
Reto/patologia
Scutellaria/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Glucuronates); 0 (Tumor Suppressor Protein p53); 16IGP0ML9A (scutellarin); 7V515PI7F6 (Apigenin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2016.6081


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[PMID]:27799444
[Au] Autor:Pramanik P; Vidua RK; Patel S
[Ad] Endereço:1 Ministry of National Security, Kingston, Jamaica.
[Ti] Título:Severing of skull cap: A rare trauma attributed to transportation of bulldozer.
[So] Source:Med Leg J;85(1):43-46, 2017 Mar.
[Is] ISSN:2042-1834
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bulldozer fatalities are usually due to accidental crushing of the body at the workplace. However, severance of the skull cap simulating a chopping injury to head is rare in the literature. Medico-legal investigation may be posed with different challenges when carrying out an autopsy of a victim with this devastating head injury. The police will seek an opinion about the type of weapon responsible for the injuries, the nature of injuries produced and manner of death. In the present case, the victim was hit at dusk by a protruding part of the bulldozer blade as he crossed in front of a bulldozer that was approaching his tractor from the opposite side of the road. His skull cap was severed and he died instantly. This report considers the circumstances of his death, its mechanisms and strategies for preventing such deaths.
[Mh] Termos MeSH primário: Medicina Legal/métodos
Metalurgia
Veículos Automotores
Scutellaria
Ferimentos e Lesões/complicações
Ferimentos e Lesões/etiologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Ferimentos e Lesões/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE
[do] DOI:10.1177/0025817216677008


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[PMID]:27545726
[Au] Autor:Mamadalieva NZ; Sharopov F; Satyal P; Azimova SS; Wink M
[Ad] Endereço:a Laboratory of the Chemistry of Glycosides Institute of the Chemistry of Plant Substances , Tashkent , Uzbekistan.
[Ti] Título:Composition of the essential oils of three Uzbek Scutellaria species (Lamiaceae) and their antioxidant activities.
[So] Source:Nat Prod Res;31(10):1172-1176, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chemical composition of the essential oils obtained from aerial parts of Scutellaria immaculata Nevski ex Juz., Scutellaria ramosissima M. Pop. and Scutellaria schachristanica Juz. (Lamiaceae) growing wild in Uzbekistan was analysed by GC and GC-MS. The main constituents of the essential oils from S. immaculata were acetophenone (30.39%), eugenol (20.61%), thymol (10.04%) and linalool (6.92%), whereas constituents of the essential oils fromS. schachristanica were acetophenone (34.74%), linalool (26.98%) and eugenol (20.67%). The S. ramosissima oil is dominated by germacrene D (23.96%), ß-caryophyllene (11.09%), linalool (9.63%) and hexadecanoic acid (8.34%). The essential oils of Scutellaria species exhibited weaker antioxidant effects in DPPH, ABTS and FRAP assays. In FRAP assay, only eugenol exhibited a substantial reducing power IC = 2476.92 ± 15.8 (mM Fe(II)/g).
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Scutellaria/química
[Mh] Termos MeSH secundário: Benzotiazóis/química
Compostos de Bifenilo/química
Cromatografia Gasosa-Espectrometria de Massas
Monoterpenos/análise
Picratos/química
Extratos Vegetais
Sesquiterpenos/análise
Sesquiterpenos de Germacrano/análise
Ácidos Sulfônicos/química
Uzbequistão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Picrates); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Germacrane); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); BHW853AU9H (caryophyllene); D81QY6I88E (linalool); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); V2I9ATG34E (germacrene D)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1222383


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[PMID]:28174795
[Au] Autor:Bejenaru C; Mogosanu GD; Bejenaru LE; BiTa A; Balseanu TA; Ionica FE
[Ad] Endereço:Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania; ludovic_bejenaru@yahoo.com.
[Ti] Título:Effect of Scutellariae herba extracts in experimental model of skin burns: histological and immunohistochemical assessment.
[So] Source:Rom J Morphol Embryol;57(4):1285-1294, 2016.
[Is] ISSN:1220-0522
[Cp] País de publicação:Romania
[La] Idioma:eng
[Ab] Resumo:The skin burns are an issue of great interest and seriousness in the public health domain, by their destructive features. Natural medicinal products are extensively used from ancient times, in ethnopharmacology, for the treatment of skin injuries (burns, wounds, ulcerations) due to the local modulation of the cellular response, in terms of emollient, demulcent, astringent, anti-inflammatory, antimicrobial, epithelizing, wound-healing, immunomodulatory and antioxidant effects. AIM: Histological and immunohistochemical assessment of antiseptic, anti-inflammatory, astringent and cicatrizing effects of Scutellariae (altissimae, galericulatae, hastifoliae) herba extracts administered in the form of 20% topical preparations (cold-creams), in experimental model of third degree skin burns, at Wistar rats. Caffeic acid and chlorogenic acid derivatives were identified in all herbal samples. The most active was the cold-cream with 20% Scutellariae hastifoliae herba soft extract, promoting the neoangiogenesis vessels and granulation tissue. Flavonoids, tannins and polyphenol carboxylic acids are the main active principles responsible for antiseptic, anti-inflammatory, astringent and cicatrizing effects of herbal extracts. Beeswax, from the formulation of cold-creams, acts as emollient, epithelizing, cicatrizing and biostimulator.
[Mh] Termos MeSH primário: Produtos Biológicos/química
Queimaduras/tratamento farmacológico
Extratos Vegetais/química
Scutellaria/química
Pele/patologia
[Mh] Termos MeSH secundário: Animais
Produtos Biológicos/farmacologia
Queimaduras/patologia
Imuno-Histoquímica
Modelos Teóricos
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE


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[PMID]:28167480
[Au] Autor:Zhang Y; Li Y
[Ad] Endereço:The First Affiliated Hospital of Henan University of TCM, Zhengzhou, China.
[Ti] Título:Effect of total flavonoids of Scutellaria barbata on cognitive function and nogo-A expression in the hippocampus in cerebral ischemia model in gerbils.
[So] Source:Pak J Pharm Sci;29(6 Suppl):2373-2376, 2016 Nov.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:To explore the effect of total flavonoids of Scutellaria barbata on cognitive function and nogo-A expression in the hippocampus region in cerebral ischemia model in gerbils. 30 gerbils were randomly divided into model group, sham operation group, large dose of total flavonoids of Scutellaria barbata group (large dose group), middle dose of total flavonoids of Scutellaria barbata group (middle dose group) and small dose of total flavonoids of Scutellaria barbata group (small dose group), with 6 cases in each group. All the groups except the sham operation group were received bilateral common carotid artery ligation to establish the cerebral ischemia model in gerbils. After that, the large, middle and small doses groups were given 400mg/kg, 200mg/kg and 100mg/kg of total flavonoids of Scutellaria barbata respectively, while the other two groups were injected with sodium chloride for 4 continuous weeks. At the 5th and 8th week after modeling, the cognitive function (e.g. escape latency period and original platform crossing times) of the gerbils in the three groups were detected by Morris water maze test. Moreover, the nogo-A expressions in the hippocampus region were detected by immunohistochemical staining method at the 8th week. The escape latency period and platform crossing times at the 5th and 8th week after modeling in the large dose group were significantly higher than the rest groups (except slam operation group) (p<0.05), while the difference was not significant when compared with slam operation group (p>0.05). The difference of the gray value of nogo-A positive cells in hippocampus in the large dose group was not significant compared with middle dose group and sham operation group (p>0.05), while it was significant compared with model group and small dose group (p<0.05). Large dose of total flavonoids of Scutellaria barbata can obviously improve the cognitive function in cerebral ischemia model in gerbils by reducing nogo-A expression in the hippocampus region.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Isquemia Encefálica/tratamento farmacológico
Cognição/efeitos dos fármacos
Flavonoides/farmacologia
Hipocampo/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Proteínas Nogo/metabolismo
Extratos Vegetais/farmacologia
Scutellaria/química
[Mh] Termos MeSH secundário: Animais
Isquemia Encefálica/metabolismo
Isquemia Encefálica/fisiopatologia
Isquemia Encefálica/psicologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Regulação para Baixo
Flavonoides/isolamento & purificação
Gerbillinae
Hipocampo/metabolismo
Hipocampo/fisiopatologia
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Fármacos Neuroprotetores/isolamento & purificação
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Neuroprotective Agents); 0 (Nogo Proteins); 0 (Plant Extracts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE


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Fotocópia
[PMID]:27931218
[Au] Autor:Wu XG; Wang SS; Miao H; Cheng JJ; Zhang SF; Shang YZ
[Ad] Endereço:Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia/Institute of Traditional Chinese Medicine, Chengde Medical College/Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde, Hebei, 067000, China.
[Ti] Título:Scutellaria barbata flavonoids alleviate memory deficits and neuronal injuries induced by composited Aß in rats.
[So] Source:Behav Brain Funct;12(1):33, 2016 Dec 08.
[Is] ISSN:1744-9081
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of the present study was to investigate the effects of Scutellaria barbata flavonoids (SBF) on memory impairment and neuronal injury induced by amyloid beta protein 25-35 in combination with aluminum trichloride (AlCl3) and recombinant human transforming growth factor-ß1 (RHTGF-ß1) (composited Aß) in rats. METHODS: The composited Aß-treated model of Alzheimer's disease (AD)-like memory impairment and neuronal injury was established in male rats by right intracerebroventricular injection of composited Aß, and the effects of SBF were assessed using this rat model. Spatial learning and memory of rats were assessed in the Morris water maze, and neuronal injury was assessed by light and electron microscopy with hematoxylin-eosin or uranyl acetate and lead nitrate-sodium citrate staining, respectively. RESULTS: In the Morris water maze, memory impairment was observed in 94.7% of the composited Aß-treated rats. The composited Aß-treated rats took longer than sham-operated rats to find the hidden platform during position navigation and reversal learning trials. They also spent less time swimming in the target quadrant in the probe trial. Optical and electron microscopic observations showed significant neuropathological changes including neuron loss or pyknosis in hippocampus, typical colliquative necrosis in cerebral cortex, mitochondrial swelling and cristae fragmentation and a large number of lipofuscin deposits in the cytoplasm. Treatment with SBF (35-140 mg/kg) reduced the memory impairment and neuronal injury induced by composited Aß. CONCLUSION: SBF-mediated improvement of composited Aß-induced memory impairment and neuronal injury in rats provides an appropriate rationale for evaluating SBF as a promising agent for treatment of AD.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/toxicidade
Flavonoides/uso terapêutico
Transtornos da Memória/tratamento farmacológico
Neurônios/efeitos dos fármacos
Fragmentos de Peptídeos/toxicidade
Extratos Vegetais/uso terapêutico
Scutellaria
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Seres Humanos
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Aprendizagem em Labirinto/fisiologia
Transtornos da Memória/induzido quimicamente
Transtornos da Memória/patologia
Neurônios/patologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Flavonoids); 0 (Peptide Fragments); 0 (Plant Extracts); 0 (amyloid beta-protein (25-35))
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE



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