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[PMID]: | 28174795 |
[Au] Autor: | Bejenaru C; Mogosanu GD; Bejenaru LE; BiTa A; Balseanu TA; Ionica FE |
[Ad] Endereço: | Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania; ludovic_bejenaru@yahoo.com. |
[Ti] Título: | Effect of Scutellariae herba extracts in experimental model of skin burns: histological and immunohistochemical assessment. |
[So] Source: | Rom J Morphol Embryol;57(4):1285-1294, 2016. | [Is] ISSN: | 1220-0522 |
[Cp] País de publicação: | Romania |
[La] Idioma: | eng |
[Ab] Resumo: | The skin burns are an issue of great interest and seriousness in the public health domain, by their destructive features. Natural medicinal products are extensively used from ancient times, in ethnopharmacology, for the treatment of skin injuries (burns, wounds, ulcerations) due to the local modulation of the cellular response, in terms of emollient, demulcent, astringent, anti-inflammatory, antimicrobial, epithelizing, wound-healing, immunomodulatory and antioxidant effects. AIM: Histological and immunohistochemical assessment of antiseptic, anti-inflammatory, astringent and cicatrizing effects of Scutellariae (altissimae, galericulatae, hastifoliae) herba extracts administered in the form of 20% topical preparations (cold-creams), in experimental model of third degree skin burns, at Wistar rats. Caffeic acid and chlorogenic acid derivatives were identified in all herbal samples. The most active was the cold-cream with 20% Scutellariae hastifoliae herba soft extract, promoting the neoangiogenesis vessels and granulation tissue. Flavonoids, tannins and polyphenol carboxylic acids are the main active principles responsible for antiseptic, anti-inflammatory, astringent and cicatrizing effects of herbal extracts. Beeswax, from the formulation of cold-creams, acts as emollient, epithelizing, cicatrizing and biostimulator. |
[Mh] Termos MeSH primário: |
Produtos Biológicos/química Queimaduras/tratamento farmacológico Extratos Vegetais/química Scutellaria/química Pele/patologia
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[Mh] Termos MeSH secundário: |
Animais Produtos Biológicos/farmacologia Queimaduras/patologia Imuno-Histoquímica Modelos Teóricos Extratos Vegetais/farmacologia Ratos Ratos Wistar
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Biological Products); 0 (Plant Extracts) |
[Em] Mês de entrada: | 1705 |
[Cu] Atualização por classe: | 170502 |
[Lr] Data última revisão:
| 170502 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170209 |
[St] Status: | MEDLINE |
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