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[PMID]: 29304179 [Au] Autor: Cutillas AB; Carrasco A; Martinez-Gutierrez R; Tomas V; Tudela J [Ad] Endereço: GENZ-Group of research on Enzymology, Department of Biochemistry and Molecular Biology-A, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Murcia, Spain. [Ti] Título: Thymus mastichina L. essential oils from Murcia (Spain): Composition and antioxidant, antienzymatic and antimicrobial bioactivities. [So] Source: PLoS One;13(1):e0190790, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The compositions of essential oils (EOs) from Spanish marjoram (Thymus mastichina L.) grown in several bioclimatic zones of Murcia (SE Spain) were studied to determine their absolute and relative concentrations using gas chromatography-mass spectrometry. 1,8-Cineole and linalool were the main components, followed by α-pinene, ß-pinene and α-terpineol. (-)-Linalool, (+)-α-terpineol and (+)-α-pinene were the most abundant enantiomers. When the antioxidant capacities of T. mastichina EOs and their compounds were measured by five methods, EOs and linalool, linalyl acetate, α-terpinene and γ-terpinene, among others, showed antioxidant activities. All four T. mastichina EOs inhibited both lipoxygenase and acetylcholinesterase activities, and they might be useful for further research into inflammatory and Alzheimer diseases. Bornyl acetate and limonene showed the highest lipoxygenase inhibition and 1,8-cineole was the best acetylcholinesterase inhibitor. Moreover, these EOs inhibited the growth of Escherichia coli, Staphylococcus aureus and Candida albicans due to the contribution of their individual compounds. The results underline the potential use of these EOs in manufactured products, such as foodstuff, cosmetics and pharmaceuticals. [Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia Antioxidantes/farmacologia Inibidores Enzimáticos/farmacologia Óleos Voláteis/isolamento & purificação Thymus (Planta)/química [Mh] Termos MeSH secundário: Candida albicans/efeitos dos fármacos Escherichia coli/efeitos dos fármacos Cromatografia Gasosa-Espectrometria de Massas Óleos Voláteis/química Óleos Voláteis/farmacologia Staphylococcus aureus/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Enzyme Inhibitors); 0 (Oils, Volatile) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180106 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0190790

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[PMID]: 28800826 [Au] Autor: Siroli L; Patrignani F; Serrazanetti DI; Vernocchi P; Del Chierico F; Russo A; Torriani S; Putignani L; Gardini F; Lanciotti R [Ad] Endereço: Department of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, Campus of Food Science, Piazza Goidanich 60, 47521 Cesena, Italy. [Ti] Título: Effect of thyme essential oil and Lactococcus lactis CBM21 on the microbiota composition and quality of minimally processed lamb's lettuce. [So] Source: Food Microbiol;68:61-70, 2017 Dec. [Is] ISSN: 1095-9998 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The main aim of this work was to evaluate, at pilot scale in an industrial environment, the effects of the biocontrol agent Lactococcus lactis CBM21 and thyme essential oil compared to chlorine, used in the washing step of fresh-cut lamb's lettuce, on the microbiota and its changes in relation to the time of storage. The modification of the microbial population was studied through pyrosequencing in addition to the traditional plate counts. In addition, the volatile molecule and sensory profiles were evaluated during the storage. The results showed no significant differences in terms of total aerobic mesophilic cell loads in relation to the washing solution adopted. However, the pyrosequencing data permitted to identify the genera and species able to dominate the spoilage associations over storage in relation to the treatment applied. Also, the analyses of the volatile molecule profiles of the samples during storage allowed the identification of specific molecules as markers of the spoilage for each different treatment. The sensory analyses after 3 and 5 days of storage showed the preference of the panelists for samples washed with the combination thyme EO and the biocontrol agent. These samples were preferred for attributes such as flavor, acceptability and overall quality. These results highlighted the effect of the innovative washing solutions on the quality of lettuce through the shift of microbiota towards genera and species with lower potential in decreasing the sensory properties of the product. [Mh] Termos MeSH primário: Bactérias/efeitos dos fármacos Lactococcus lactis/fisiologia Alface/microbiologia Óleos Voláteis/farmacologia Extratos Vegetais/farmacologia Thymus (Planta)/química Verduras/microbiologia [Mh] Termos MeSH secundário: Bactérias/classificação Bactérias/crescimento & desenvolvimento Bactérias/isolamento & purificação Biodiversidade Contaminação de Alimentos/prevenção & controle Óleos Voláteis/isolamento & purificação Extratos Vegetais/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Oils, Volatile); 0 (Plant Extracts) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170813 [St] Status: MEDLINE

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[PMID]: 28722406 [Au] Autor: Reyer H; Zentek J; Männer K; Youssef IMI; Aumiller T; Weghuber J; Wimmers K; Mueller AS [Ad] Endereço: Leibniz Institute for Farm Animal Biology (FBN), Institute for Genome Biology , Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany. [Ti] Título: Possible Molecular Mechanisms by Which an Essential Oil Blend from Star Anise, Rosemary, Thyme, and Oregano and Saponins Increase the Performance and Ileal Protein Digestibility of Growing Broilers. [So] Source: J Agric Food Chem;65(32):6821-6830, 2017 Aug 16. [Is] ISSN: 1520-5118 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Phytogenic feed additives represent a potential alternative to antibiotics with attributed health and growth-promoting effects. Chickens supplemented with an essential oil blend, a Quillaja saponin blend, or a combination of both phytogenic preparations showed a comprehensively and significantly improved apparent ileal digestibility of crude protein and amino acids compared to control birds. Accordingly, holistic transcriptomic analyses of jejunum and liver samples indicated alterations of macromolecule transporters and processing pathways likely culminating in an increased uptake and metabolizing of carbohydrates and fatty acids. Complementary analyses in Caco-2 showed a significant increase in transporter recruitment to the membrane (SGLT1 and PEPT1) after addition of essential oils and saponins. Although the penetrance of effects differed for the used phytogenic feed additives, the results indicate for an overlapping mode of action including local effects at the intestinal border and systemic alterations of macronutrient metabolism resulting in an improved performance of broilers. [Mh] Termos MeSH primário: Ração Animal/análise Galinhas/metabolismo Aditivos Alimentares/metabolismo Íleo/metabolismo Illicium/química Óleos Voláteis/metabolismo Origanum/metabolismo Rosmarinus/metabolismo Saponinas/metabolismo Thymus (Planta)/metabolismo [Mh] Termos MeSH secundário: Animais Células CACO-2 Galinhas/genética Galinhas/crescimento & desenvolvimento Digestão Seres Humanos Óleos Voláteis/análise Origanum/química Proteínas/genética Proteínas/metabolismo Rosmarinus/química Saponinas/análise Thymus (Planta)/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Food Additives); 0 (Oils, Volatile); 0 (Proteins); 0 (Saponins) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170825 [Lr] Data última revisão: 170825 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170720 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jafc.7b01925

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[PMID]: 28705510 [Au] Autor: Schött G; Liesegang S; Gaunitz F; Gleß A; Basche S; Hannig C; Speer K [Ad] Endereço: Special Food Chemistry and Food Production, TU Dresden, Bergstraße 66, 01069 Dresden, Germany. [Ti] Título: The chemical composition of the pharmacologically active Thymus species, its antibacterial activity against Streptococcus mutans and the antiadherent effects of T. vulgaris on the bacterial colonization of the in situ pellicle. [So] Source: Fitoterapia;121:118-128, 2017 Sep. [Is] ISSN: 1873-6971 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The pharmacological active genus Thymus L. comprises over 200 species. Besides its traditional pharmacological use, thyme may reduce the risk of caries disease, however, there is very little respective literature. The pharmacological effects can be attributed to the secondary plant metabolites. The composition of the essential oil and the polyphenols is important for the evaluation of the pharmacological activity. Nevertheless, there are no studies regarding a comparative analysis of the different pharmacological thyme species. In the present study, four different pharmacology Thymus species were cultivated under comparable conditions, and the volatile compounds as well as the polyphenols were characterized. In addition, the in vitro antibacterial activity against S. mutans, one of the primary cariogenic bacterial species, as well as of the essential oil and of the polyphenols were investigated. Furthermore, the bacterial viability and its effect on the initial bacterial adhesion under oral conditions were evaluated in situ for the essential oil and the polyphenols. By GC-MS, 69 volatile compounds, and by LC-DAD-MS/MS, 46 polyphenols could be identified. The comprehensive examination of the essential oils and the polyphenols revealed that the main compounds were equal. However, the yield of the essential oil and the polyphenol content differed clearly. The essential oils of the four investigated Thymus species exhibited an antibacterial activity against S. mutans in vitro, in contrast to the polyphenols of T. vulgaris. Rinsing with polyphenol-rich infusions reduced the initial bacterial colonization while the essential oil inhibited the bacterial growth on dental enamel in situ. [Mh] Termos MeSH primário: Antibacterianos/farmacologia Aderência Bacteriana/efeitos dos fármacos Óleos Voláteis/farmacologia Polifenóis/farmacologia Thymus (Planta)/química [Mh] Termos MeSH secundário: Animais Bovinos Esmalte Dentário/microbiologia Seres Humanos Óleos Voláteis/química Óleos Vegetais/química Streptococcus mutans/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Polyphenols) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170715 [St] Status: MEDLINE

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[PMID]: 28411462 [Au] Autor: Desta KT; Kim GS; Abd El-Aty AM; Raha S; Kim MB; Jeong JH; Warda M; Hacimüftüoglu A; Shin HC; Shim JH; Shin SC [Ad] Endereço: Department of Chemistry and Research Institute of Life Sciences, Gyeongsang National University, Jinju, 660-701, Republic of Korea. [Ti] Título: Flavone polyphenols dominate in Thymus schimperi Ronniger: LC-ESI-MS/MS characterization and study of anti-proliferative effects of plant extract on AGS and HepG2 cancer cells. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1053:1-8, 2017 05 15. [Is] ISSN: 1873-376X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Thymus schimperi is a highly localized and a rare plant endemic to Ethiopia. An optimized and validated high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method was applied to characterize 23 polyphenolic compounds found in ethyl acetate extracts of the plant. From those, flavones dominated and luteolin was the major component contributing 21.83% of the total composition (or 46.05±0.59g/kg of fresh sample weight). Validation data showed a determination coefficient (R )≥0.997. Limits of detection (LOD) and quantification (LOQ) were 0.03-0.97 and 0.11-3.23mg/L, while recovery values spiked at 5 and 50mg/L were between 70.89-115.39 and 67.65-120.19%, respectively. Except for caffeic acid and epicatechin gallate, the relative standard deviations (%RSDs) were far below 15%, showing acceptable precision values. The plant extracts inhibited cell proliferation and induced cell death in human gastric adenocarcinoma (AGS) and liver hepatocellular carcinoma (HepG2) cancer cells. This is the first report of polyphenolic components from T. schimperi being characterized using HPLC-ESI-MS/MS. Being components of many edible vegetables, fruits, and spices, the identified polyphenols suggest that T. schimperi could be a potential food with promising health benefits. [Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/análise Antineoplásicos Fitogênicos/farmacologia Proliferação Celular/efeitos dos fármacos Polifenóis/análise Polifenóis/farmacologia Thymus (Planta)/química [Mh] Termos MeSH secundário: Linhagem Celular Tumoral Cromatografia Líquida de Alta Pressão Flavonas/análise Flavonas/farmacologia Células Hep G2 Seres Humanos Limite de Detecção Neoplasias/tratamento farmacológico Espectrometria de Massas por Ionização por Electrospray Espectrometria de Massas em Tandem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents, Phytogenic); 0 (Flavones); 0 (Polyphenols) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170620 [Lr] Data última revisão: 170620 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170416 [St] Status: MEDLINE

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[PMID]: 28362473 [Au] Autor: Hes M; Gliszczynska-Swiglo A; Gramza-Michalowska A [Ad] Endereço: Department of Food Service and Catering, Poznan University of Life Sciences, Poland. [Ti] Título: The effect of antioxidants on quantitative changes of lysine and methionine in linoleic acid emulsions at different pH conditions. [So] Source: Acta Sci Pol Technol Aliment;16(1):53-67, 2017 Jan-Mar. [Is] ISSN: 1898-9594 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: BACKGROUND: Plants are an important source of phenolic compounds. The antioxidant capacities of green tea, thyme and rosemary extracts that contain these compounds have been reported earlier. However, there is a lack of accessible information about their activity against lipid oxidation in emulsions and inhibit the interaction of lipid oxidation products with amino acids. Therefore, the influence of green tea, thyme and rosemary extracts and BHT (butylated hydroxytoluene) on quantitative changes in lysine and methionine in linoleic acid emulsions at a pH of isoelectric point and a pH lower than the isoelectric point of amino acids was investigated. METHODS: Total phenolic contents in plant extracts were determined spectrophotometrically by using Folin-Ciocalteu's reagent, and individual phenols by using HPLC. The level of oxidation of emulsion was determined using the measurement of peroxides and TBARS (thiobarbituric acid reactive substances). Methionine and lysine in the system were reacted with sodium nitroprusside and trinitrobenzenesulphonic acid respectively, and the absorbance of the complexes was measured. RESULTS: Extract of green tea had the highest total polyphenol content. The system containing antioxidants and amino acid protected linoleic acid more efficiently than by the addition of antioxidants only. Lysine and methionine losses in samples without the addition of antioxidants were lower in their isoelectric points than below these points. Antioxidants decrease the loss of amino acids. The protective properties of antioxidants towards methionine were higher in a pH of isoelectric point whereas towards lysine in pH below this point. CONCLUSIONS: Green tea, thyme and rosemary extracts exhibit antioxidant activity in linoleic acid emulsions. Moreover, they can be utilized to inhibit quantitative changes in amino acids in lipid emulsions. However, the antioxidant efficiency of these extracts seems to depend on pH conditions. Further investigations should be carried out to clarify this issue. [Mh] Termos MeSH primário: Antioxidantes/química Lisina/análise Metionina/análise [Mh] Termos MeSH secundário: Hidroxitolueno Butilado/química Emulsões Concentração de Íons de Hidrogênio Ácido Linoleico/análise Extratos Vegetais/química Polifenóis/química Rosmarinus/química Chá/química Substâncias Reativas com Ácido Tiobarbitúrico/análise Thymus (Planta)/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Emulsions); 0 (Plant Extracts); 0 (Polyphenols); 0 (Tea); 0 (Thiobarbituric Acid Reactive Substances); 1P9D0Z171K (Butylated Hydroxytoluene); 9KJL21T0QJ (Linoleic Acid); AE28F7PNPL (Methionine); K3Z4F929H6 (Lysine) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170622 [Lr] Data última revisão: 170622 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170401 [St] Status: MEDLINE [do] DOI: 10.17306/J.AFS.2017.0455

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[PMID]: 28359985 [Au] Autor: Arslan Burnaz N; Küçük M; Akar Z [Ad] Endereço: Department of Nutrition and Dietetics, Faculty of Health Sciences, Gümüshane University, 29100 Gümüshane, Turkey. Electronic address: nsbburnaz@gmail.com. [Ti] Título: An on-line HPLC system for detection of antioxidant compounds in some plant extracts by comparing three different methods. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1052:66-72, 2017 May 01. [Is] ISSN: 1873-376X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Echinacea (Echinacea purpurea), green tea (Camellia sinensis) and yaylacayi (Thymus praecox OPIZ subsp. grossheimii (Ronniger) Jalas) are herbs used in traditional medicine because of their beneficial health effects. A high performance liquid chromatography (HPLC) post-column method was developed by coupling HPLC with on-line antioxidant assays using diode array (DAD) and ultraviolet (UV) detectors. Thus antioxidant compounds and fifteen phenolic standards were detected in echinacea, green tea and yaylacayi methanol extracts simultaneously. Later on, the developed on-line HPLC coupled system was used to compare three different antioxidant methods, ABTS [2,2'-Azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)], DPPH (2,2-diphenyl-1-picrylhydrazyl and FRAP (Ferric reducing antioxidant power). Eight compounds with antioxidant activity were identified as gallic acid, protocatechuic aldehyde, p-OH benzoic acid, chlorogenic acid, caffeic acid, vanillin, ferulic acid, and rosmarinic acid. For validation purposes, LOD (limit of detection) (0.36-14.68µg/mL) and LOQ (limit of quantification) (1.35-48.92µg/mL) values were calculated for six standards. The results showed that while the post-column ABTS and FRAP assays were repeatable, sensitive and supportive of each other, the post-column DPPH assay did not provide reliable results. Also due to the base-line noise and drifts in post-column DPPH assay, identification and quantitation of analytes could not be done accurately. [Mh] Termos MeSH primário: Antioxidantes/análise Cromatografia Líquida de Alta Pressão/métodos Medicamentos de Ervas Chinesas/análise Fenóis/análise [Mh] Termos MeSH secundário: Antioxidantes/farmacologia Benzotiazóis/química Compostos de Bifenilo/química Camellia sinensis/química Medicamentos de Ervas Chinesas/farmacologia Echinacea/química Radicais Livres/química Fenóis/farmacologia Picratos/química Ácidos Sulfônicos/química Thymus (Planta)/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Drugs, Chinese Herbal); 0 (Free Radicals); 0 (Phenols); 0 (Picrates); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170526 [Lr] Data última revisão: 170526 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170401 [St] Status: MEDLINE

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[PMID]: 28334192 [Au] Autor: Gaire S; O'Connell M; Holguin FO; Amatya A; Bundy S; Romero A [Ad] Endereço: Department of Entomology, Plant Pathology and Weed Science New Mexico State University, Las Cruces, NM 88003 (sgaire@purdue.edu; cbundy@nmsu.edu; aromero2@nmsu.edu). [Ti] Título: Insecticidal Properties of Essential Oils and Some of Their Constituents on the Turkestan Cockroach (Blattodea: Blattidae). [So] Source: J Econ Entomol;110(2):584-592, 2017 Apr 01. [Is] ISSN: 1938-291X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The Turkestan cockroach, Blatta lateralis (Walker), has become the most important peridomestic species in urban areas of the Southwestern United States. The aim of this study was to evaluate the use of botanical compounds to control this urban pest. We tested the acute toxicity and repellency of six botanical constituents and three essential oils on Turkestan cockroach nymphs. Chemical composition of the essential oils was also determined. Topical and fumigant assays with nymphs showed that thymol was the most toxic essential oil constituent, with a LD50 of 0.34 mg/nymph and a LC50 of 27.6 mg/liter air, respectively. Contact toxicity was also observed in assays with trans-Cinnamaldehyde, eugenol, geraniol, methyl eugenol, and p-Cymene. Methyl eugenol and geraniol had limited fumigant toxicity. The essential oils from red thyme, clove bud, and Java citronella exhibited toxicity against nymphs. Cockroaches avoided fresh dry residues of thymol and essential oils. Chemical analysis of the essential oils confirmed high contents of effective essential oil constituents. Our results demonstrated that essential oils and some of their constituents have potential as eco-friendly insecticides for the management of Turkestan cockroaches. [Mh] Termos MeSH primário: Baratas/efeitos dos fármacos Inseticidas/farmacologia Óleos Voláteis/química Óleos Voláteis/farmacologia [Mh] Termos MeSH secundário: Animais Comportamento Animal/efeitos dos fármacos Óleo de Cravo/química Fumigação/métodos Controle de Insetos/métodos Inseticidas/química Dose Letal Mediana Ninfa Thymus (Planta)/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Clove Oil); 0 (Insecticides); 0 (Oils, Volatile) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170809 [Lr] Data última revisão: 170809 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170324 [St] Status: MEDLINE [do] DOI: 10.1093/jee/tox035

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[PMID]: 28279391 [Au] Autor: Charalambous A; Lambrinou E; Katodritis N; Vomvas D; Raftopoulos V; Georgiou M; Paikousis L; Charalambous M [Ad] Endereço: Cyprus University of Technology, Department of Nursing, 15 Vragadinou Street, 3041, Limassol, Cyprus; University of Turku, Department of Nursing, Finland. Electronic address: Andreas.charalambous@cut.ac.cy. [Ti] Título: The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients: A feasibility randomized control trial. [So] Source: Eur J Oncol Nurs;27:1-8, 2017 Apr. [Is] ISSN: 1532-2122 [Cp] País de publicação: Scotland [La] Idioma: eng [Ab] Resumo: PURPOSE: Radiation-induced xerostomia is one of the most common side effects that head and neck cancer patients experience during and after treatment. Despite the various methods for the prevention and treatment of radiation-induced xerostomia, it remains highly prevalent among patients treated for head and neck cancers negatively influencing their lives. The purpose of this study was to evaluate the effectiveness of thyme honey as a means for managing radiation-induced xerostomia. METHOD: This was a parallel randomised controlled trial with two equal arms, the experimental arm (thyme honey) and the control arm (saline). 72 head and neck cancer patients receiving radiotherapy or/and chemotherapy or/and surgery were recruited in a specialised cancer centre. Patients in both arms followed the same administration protocol with thyme honey and saline respectively. Identical assessments at baseline, 1 month and 6 months following completion of the intervention were performed in both arms including the National Cancer Institute (NCI) xerostomia scale and the Xerostomia Questionnaire (XQ) additionally to weekly oral clinical assessments. The ClinicalTrials.gov Identifier for this study is NCT01465308. RESULTS: Linear Mixed Models revealed the statistically significant effect of the intervention on xerostomia (F = 8.474 p < 0.001) and overall quality of life (F = 13.158 p < 0.001). Moreover, Generalised Estimating Equations revealed a statistically significant effect on strong and unbearable pain (F = 10.524 p < 0.001) and dysphagia (F = 4.525 p = 0.033). CONCLUSION: The study has demonstrated the safety and efficacy findings of Thyme honey in head and neck cancer patients for the management of treatment induced xerostomia. [Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/complicações Neoplasias de Cabeça e Pescoço/radioterapia Mel Radioterapia/efeitos adversos Thymus (Planta)/química Xerostomia/tratamento farmacológico Xerostomia/etiologia [Mh] Termos MeSH secundário: Adulto Idoso Feminino Seres Humanos Masculino Meia-Idade Qualidade de Vida Inquéritos e Questionários [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170516 [Lr] Data última revisão: 170516 [Sb] Subgrupo de revista: IM; N [Da] Data de entrada para processamento: 170311 [St] Status: MEDLINE

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[PMID]: 28272803 [Au] Autor: Lee MH; Seo HS; Park HJ [Ad] Endereço: Dept. of Biotechnology, College of Life Sciences and Biotechnology, Korea Univ., 5-Ka, Anam-Dong, SungBuk-Ku, Seoul, 136-701, Republic of Korea. [Ti] Título: Thyme Oil Encapsulated in Halloysite Nanotubes for Antimicrobial Packaging System. [So] Source: J Food Sci;82(4):922-932, 2017 Apr. [Is] ISSN: 1750-3841 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: An antimicrobial capsule releasing thyme oil was developed using modified halloysite nanotubes (HNTs). In order to increase the pore volume, HNTs were treated with 5.0 mol/L NaOH solution, which resulted in the encapsulation of more thyme oil molecules inside the HNTs. The morphology of the raw HNTs and NaOH-treated HNTs (N-HNTs) was characterized using transmission electron microscopy and nitrogen adsorption-desorption analysis. The loading capacity increased from 180.7 ± 12.7 to 256.4 ± 16.7 mg thyme oil/g HNT after the NaOH treatment. The aerial release characteristics of thyme oil from both the HNT capsules were investigated in a closed-package atmosphere system at 4, 25, and 40 °C. The antimicrobial activity of the capsule against Escherichia coli O157:H7 was determined using the vapor phase assay. Moreover, the antimicrobial effects of the capsule against E. coli O157:H7, total mesophilic aerobic bacteria (MAB), and molds and yeasts (MY) on the surfaces of cherry tomatoes were investigated at 4 and 25 °C for 5 d. When the cherry tomatoes were exposed to the thyme oil-loaded N-HNT capsule, the number of E. coli O157:H7, MAB, and MY significantly reduced during storage. [Mh] Termos MeSH primário: Anti-Infecciosos/química Embalagem de Alimentos Nanotubos/química Óleos Vegetais/química Thymus (Planta)/química [Mh] Termos MeSH secundário: Silicatos de Alumínio/química Anti-Infecciosos/farmacologia Composição de Medicamentos Escherichia coli O157/efeitos dos fármacos Microscopia Eletrônica de Transmissão Modelos Teóricos Termogravimetria [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Aluminum Silicates); 0 (Anti-Infective Agents); 0 (Plant Oils); 1302-87-0 (clay) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170609 [Lr] Data última revisão: 170609 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170309 [St] Status: MEDLINE [do] DOI: 10.1111/1750-3841.13675

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