Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.520.987 [Categoria DeCS]
Referências encontradas : 321 [refinar]
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[PMID]:29247892
[Au] Autor:Wang WQ; Yin YP; Jun L; Xuan LJ
[Ad] Endereço:State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
[Ti] Título:Halimane-type diterpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities.
[So] Source:Phytochemistry;146:56-62, 2018 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vitex rotundifolia is the variant of the traditional Chinese medicine (TCM) Vitex trifolia. Diterpenoids from V. trifolia have shown anti-hyperlipidemia activity. As part of a continuous research program of searching for anti-hyperlipidemia constituents from TCM, 95% alcohol extract of the fruits of V. rotundifolia was fully studied, and 18 diterpenoids were isolated, including eight previously undescribed compounds (viterofolins A-H). Among them, viterofolins A-B were previously undescribed rearranged halimane-type diterpenoids, viterofolins CH were previously undescribed halimane-type diterpenoids. These compounds were then firstly evaluated in lipid (Dil-LDL) uptake assay in HepG2 cells. Viterofolin H, (5S, 6R, 8R, 9R, 10S)-6-acetoxy-9-hydroxy-13 (14)-labden-16,15-olide and previtexilactone showed moderate activities in promoting LDL uptake (1.27-1.35 fold). This work laid the foundation for searching anti-hyperlipidemia natural products.
[Mh] Termos MeSH primário: Produtos Biológicos/farmacologia
Diterpenos/farmacologia
Hiperlipidemias/tratamento farmacológico
Hipolipemiantes/farmacologia
Lipoproteínas LDL/metabolismo
Vitex/química
[Mh] Termos MeSH secundário: Produtos Biológicos/química
Produtos Biológicos/isolamento & purificação
Diterpenos/química
Diterpenos/isolamento & purificação
Células Hep G2
Seres Humanos
Hiperlipidemias/metabolismo
Hipolipemiantes/química
Hipolipemiantes/isolamento & purificação
Medicina Tradicional Chinesa
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Diterpenes); 0 (Hypolipidemic Agents); 0 (Lipoproteins, LDL); 0 (halimane)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:28602939
[Au] Autor:Luo P; Yu Q; Liu SN; Xia WJ; Fang YY; An LK; Gu Q; Xu J
[Ad] Endereço:Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
[Ti] Título:Diterpenoids with diverse scaffolds from Vitex trifolia as potential topoisomerase I inhibitor.
[So] Source:Fitoterapia;120:108-116, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Eleven new compounds, including six labdane (1-6), three halimane (7-9), and two clerodane (10-11) diterpenoids and 16 known analogues (12-27), were isolated from the leaves of Vitex trifolia. The structures of 1-11 were established by extensive 1D- and 2D-NMR and HRMS spectroscopic data. The absolute configurations of compounds 3, 7, and 10 were assigned using X-ray diffraction. Compounds 1-27 were evaluated for DNA topoisomerases I (Top1) inhibitory activity and cytotoxicity against HCT 116 cells. Compounds 8 and 11 exhibited equipotent Top1 inhibitory activity to the positive control, camptothecin (CPT), at 100µM. Compounds 8, 9, 16, and 27 showed moderate cytotoxicity at low micromolar concentrations.
[Mh] Termos MeSH primário: Diterpenos Clerodânicos/química
Inibidores da Topoisomerase I/química
Vitex/química
[Mh] Termos MeSH secundário: DNA Topoisomerases Tipo I
Diterpenos
Diterpenos Clerodânicos/isolamento & purificação
Células HCT116
Seres Humanos
Estrutura Molecular
Folhas de Planta/química
Inibidores da Topoisomerase I/isolamento & purificação
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (Diterpenes, Clerodane); 0 (Topoisomerase I Inhibitors); 0 (halimane); 0 (labdane); EC 5.99.1.2 (DNA Topoisomerases, Type I); EC 5.99.1.2 (TOP1 protein, human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28445505
[Au] Autor:Du N; Tan X; Li Q; Liu X; Zhang W; Wang R; Liu J; Guo W
[Ad] Endereço:Institute of Ecology and Biodiversity, School of Life Science, Shandong University, Jinan, Shandong Province, China.
[Ti] Título:Dominance of an alien shrub Rhus typhina over a native shrub Vitex negundo var. heterophylla under variable water supply patterns.
[So] Source:PLoS One;12(4):e0176491, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Temporal heterogeneity of a resource supply can have a profound effect on the interactions between alien and native plant species and their potential invasiveness. Precipitation patterns may be variable and result in a higher heterogeneity of water supply with global climate change. In this study, an alien shrub species, Rhus typhina, introduced to China from North America and a native shrub species, Vitex negundo var. heterophylla, were grown in monoculture and mixed culture under different water supply regimes, with four levels of water supply frequencies but with a constant level of total supplied water. After 60 days of treatments, the alien species was found to be the superior competitor in the mixed culture and was unaffected by changes in the water supply pattern. The dominance of R. typhina was mainly owing to its greater biomass and effective modulation of leaf physiology. However, in the mixed culture, V. negundo var. heterophylla exhibited both leaf- and whole-plant-level acclimations, including higher leaf length to petiole length and root to shoot biomass ratios, and lower specific leaf weight and leaf length to leaf width ratio. Plant height of V. negundo var. heterophylla was comparable to that of R. typhina in the mixed culture, which is a strategy to escape shading. Although water treatments had little effect on most traits in both species, the possible influence of water regimes should not be neglected. Compared with high-frequency water supply treatments, more individuals of V. negundo var. heterophylla died in low-water-frequency treatments when in competition with R. typhina, which may lead to species turnover in the field. The authors recommended that caution should be exercised when introducing R. typhina to non-native areas in the context of global climate change.
[Mh] Termos MeSH primário: Rhus/crescimento & desenvolvimento
Vitex/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Biomassa
Clorofila/metabolismo
Mudança Climática
Fluorometria
Espécies Introduzidas
Folhas de Planta/metabolismo
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/fisiologia
Brotos de Planta/crescimento & desenvolvimento
Brotos de Planta/fisiologia
Solo/química
Abastecimento de Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 1406-65-1 (Chlorophyll)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176491


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[PMID]:28425214
[Au] Autor:Amuri B; Maseho M; Simbi L; Okusa P; Duez P; Byanga K
[Ad] Endereço:Laboratoire de Pharmacognosie, Université de Lubumbashi, 27 avenue Kato, Lubumbashi, Democratic Republic of Congo.
[Ti] Título:Hypoglycemic and Antihyperglycemic Activities of Nine Medicinal Herbs Used as Antidiabetic in the Region of Lubumbashi (DR Congo).
[So] Source:Phytother Res;31(7):1029-1033, 2017 Jul.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assess the hypoglycemic and antihyperglycemic activities of nine plants used as antidiabetic treatments in Lubumbashi and its surroundings. Those are Albizia adianthifolia, Azanza garckeana, Cassia occidentalis, Cassia sieberiana, Erythrina abyssinica, Gladiolus klattianus, Rauvolfia caffra, Strychnos spinosa, and Vitex madiensis. Aqueous extracts, obtained by decoction and maceration, were administered (500 mg/kg) per os to guinea pigs (Cavia porcellus), both in glucose baseline conditions and in oral glucose tolerance test (OGTT) conditions (glucose, 2 g/kg; follow-up over 210 min). For OGTT experiments, area under the curve of blood glucose levels, maximum glucose concentration (Cmax), and time to reach Cmax (Tmax) were used to compare test groups with the control conditions (glucose group). In hypoglycemic tests, only three species induced significant (p < 0.001) lowering of normal glycemia: A. adianthifolia (33% reduction), C. occidentalis (32%), and V. madiensis (43%); in the same conditions, the positive control glibenclamide (6 mg/kg) induced a blood glucose lowering of 55%. In OGTT conditions, all tested herbs were active, with the highest inhibition of glycemia increases for V. madiensis (62%) and A. adianthifolia (57%), compared with the hyperglycemic inhibition rate of glibenclamide (50%). Oral glucose tolerance test conditions appear as essential to detect the extracts most interesting for clinical use. These data support the use of studied plants for diabetes treatment in traditional Congolese medicine and indicate a good knowledge of tradipraticians in the field. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Asteraceae/química
Glicemia/análise
Cassia/química
República Democrática do Congo
Diabetes Mellitus/tratamento farmacológico
Teste de Tolerância a Glucose
Glibureto/farmacologia
Cobaias
Masculino
Malvaceae/química
Medicina Tradicional
Vitex/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Plant Extracts); SX6K58TVWC (Glyburide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5814


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[PMID]:28237870
[Au] Autor:Verkaik S; Kamperman AM; van Westrhenen R; Schulte PFJ
[Ti] Título:The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis.
[So] Source:Am J Obstet Gynecol;217(2):150-166, 2017 Aug.
[Is] ISSN:1097-6868
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Premenstrual syndrome is characterized by the cyclic occurrence of physical, behavioral and psychological symptoms during the luteal phase of the menstrual cycle disappearing within a few days of the onset of menstruation. Generally symptoms are mild, but 5-8% of women suffer from severe PMS. Apart from conventional drugs, like serotonin reuptake inhibitors and oral contraceptives, complementary and alternative medicines such as Vitex agnus castus are used by many women experiencing PMS. OBJECTIVE: Our objective was to determine the efficacy, tolerability, and acceptability of Vitex agnus castus preparations for treatment of premenstrual syndrome. STUDY DESIGN: All journals in the Ovid software from inception through January 2016 were searched, including the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and PsycINFO. Gray literature was searched by Google Scholar and manufacturers of Vitex agnus castus preparations were contacted for information about unpublished trials. We included randomized controlled trials with Vitex agnus castus in women with premenstrual syndrome and/or premenstrual dysphoric disorder with a minimal duration of 2 menstrual cycles. The eligibility of the manuscripts was assessed by 2 reviewers independently. The data abstracted included characteristics of the study design, characteristics of the patient population, intervention details, type of comparator, method of diagnosis, and outcome measures. We adhered to the PRISMA guidelines. RESULTS: We found 17 randomized controlled trials of Vitex agnus castus in the treatment of premenstrual syndrome. Fourteen of these could be included in the quantitative analysis. Thirteen of 14 studies with placebo, dietary supplements, or herbal preparations as controls reported positive effects of Vitex agnus castus on total premenstrual syndrome symptoms. Unfortunately most of the trials are associated with a high risk of bias. The pooled effect of Vitex agnus castus in placebo-controlled trials was large (Hedges g, -1.21; 95% confidence interval, -1.53 to -0.88), but heterogeneity was extremely high (I , 91%). We were unable to single out factors that could explain this heterogeneity satisfactorily. The funnel plot and Egger tests suggest the presence of publication bias. CONCLUSION: Although meta-analysis shows a large pooled effect of Vitex agnus castus in placebo-controlled trials, the high risk of bias, high heterogeneity, and risk of publication bias of the included studies preclude a definitive conclusion. The pooled treatment effects should be viewed as merely explorative and, at best, overestimating the real treatment effect of Vitex agnus castus for premenstrual syndrome symptoms. There is a clear need for high-quality trials of appropriate size examining the effect of standardized extracts of Vitex agnus castus in comparison to placebo, selective serotonin reuptake inhibitors, and oral contraceptives to establish relative efficacy.
[Mh] Termos MeSH primário: Fitoterapia
Extratos Vegetais/uso terapêutico
Síndrome Pré-Menstrual/tratamento farmacológico
Vitex
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


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[PMID]:28208808
[Au] Autor:De Franciscis P; Grauso F; Luisi A; Schettino MT; Torella M; Colacurci N
[Ad] Endereço:Department of Woman, Child and General and Specialized Surgery-Second University of Naples, Largo Madonna delle Grazie, 1, 80138 Naples, Italy. pasquale.defranciscis@unina2.it.
[Ti] Título:Adding Agnus Castus and Magnolia to Soy Isoflavones Relieves Sleep Disturbances Besides Postmenopausal Vasomotor Symptoms-Long Term Safety and Effectiveness.
[So] Source:Nutrients;9(2), 2017 Feb 13.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The effectiveness for vasomotor symptoms and sleep disorders plus the long-term safety of a nutraceutical combination of and magnolia extracts combined with soy isoflavones (SI) and lactobacilli were assessed in postmenopausal women. A controlled study was carried out in menopausal women comparing this nutraceutical combination (ESP group) with a formulation containing isoflavones alone (C group) at the dosage recommended. The Kuppermann index, The Pittsburgh Sleep Quality Index (PSQI), and Short Form 36 (SF-36) were determined at baseline, three, six and 12 months. Endometrial thickness, mammary density and liver function were evaluated at baseline and after 12 months. One hundred and eighty women were enrolled in the study (100 in the ESP group and 80 in the C group). At the end of the treatment, mammary density, endometrial thickness, and hepatic function did not show substantial differences between groups. The Kuppermann index and particularly the tendency for hot flashes progressively and significantly decreased in frequency and severity during ESP versus C treatment. At the same time, a significant increase in sleep quality and psychophysical wellness parameters was observed in the ESP versus C groups. No adverse events were observed. and magnolia, combined with SI + lactobacilli, can effectively and safely be used in symptomatic postmenopausal women, mainly when quality of sleep is the most disturbing complaint. The endometrium, mammary glands and liver function were unaffected after 12 months of treatment.
[Mh] Termos MeSH primário: Isoflavonas/administração & dosagem
Magnolia/química
Fitoterapia
Pós-Menopausa/efeitos dos fármacos
Sono/efeitos dos fármacos
Feijão de Soja/química
Vitex/química
[Mh] Termos MeSH secundário: Idoso
Suplementos Nutricionais
Endométrio/efeitos dos fármacos
Endométrio/metabolismo
Feminino
Fogachos/tratamento farmacológico
Seres Humanos
Lactobacillus/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Glândulas Mamárias Humanas/efeitos dos fármacos
Glândulas Mamárias Humanas/metabolismo
Meia-Idade
Preparações de Plantas/farmacologia
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Isoflavones); 0 (Plant Preparations)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:28165811
[Au] Autor:Piazzini V; Monteforte E; Luceri C; Bigagli E; Bilia AR; Bergonzi MC
[Ad] Endereço:a Department of Chemistry, University of Florence , Sesto Fiorentino , FI , Italy and.
[Ti] Título:Nanoemulsion for improving solubility and permeability of Vitex agnus-castus extract: formulation and in vitro evaluation using PAMPA and Caco-2 approaches.
[So] Source:Drug Deliv;24(1):380-390, 2017 Nov.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to develop new formulation for an improved oral delivery of Vitex agnus-castus (VAC) extract. After the optimization and validation of analytical method for quali-quantitative characterization of extract, nanoemulsion (NE) was selected as lipid-based nanocarrier. The composition of extract-loaded NE resulted in triacetin as oil phase, labrasol as surfactant, cremophor EL as co-surfactant and water. NE contains until 60 mg/mL of extract. It was characterized by DLS and TEM analyses and its droplets appear dark with an average diameter of 11.82 ± 0.125 nm and a polydispersity index (PdI) of 0.117 ± 0.019. The aqueous solubility of the extract was improved about 10 times: the extract is completely soluble in the NE at the concentration of 60 mg/mL, while its solubility in water results less than 6 mg. The passive intestinal permeation was tested by using parallel artificial membrane permeation assay (PAMPA) and the permeation across Caco-2 cells after preliminary cytotoxicity studies were also evaluated. NE shows a good solubilizing effect of the constituents of the extract, compared with aqueous solution. The total amount of constituents permeated from NE to acceptor compartment is greater than that permeated from saturated aqueous solution. Caco-2 test confirmed PAMPA results and they revealed that NE was successful in increasing the permeation of VAC extract. This formulation could improve oral bioavailability of extract due to enhanced solubility and permeability of phytocomplex.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/metabolismo
Absorção Intestinal
Membranas Artificiais
Nanopartículas/química
Nanopartículas/metabolismo
[Mh] Termos MeSH secundário: Células CACO-2
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Composição de Medicamentos
Avaliação Pré-Clínica de Medicamentos/métodos
Medicamentos de Ervas Chinesas/administração & dosagem
Emulsões
Seres Humanos
Absorção Intestinal/efeitos dos fármacos
Absorção Intestinal/fisiologia
Nanopartículas/administração & dosagem
Tamanho da Partícula
Permeabilidade/efeitos dos fármacos
Solubilidade/efeitos dos fármacos
Vitex
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Emulsions); 0 (Membranes, Artificial); 0 (Vitex agnus castus extract)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1080/10717544.2016.1256002


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[PMID]:28049908
[Au] Autor:Rasyid FA; Fukuyoshi S; Ando H; Miyake K; Atsumi T; Fujie T; Saito Y; Goto M; Shinya T; Mikage M; Sasaki Y; Nakagawa-Goto K
[Ad] Endereço:School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University.
[Ti] Título:A Novel Clerodane Diterpene from Vitex cofassus.
[So] Source:Chem Pharm Bull (Tokyo);65(1):116-120, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:New clerodane diterpene, 16-hydroxy-pentandralactone (1) and known diterpene acuminolide (2) were isolated from the methanol extract of Vitex cofassus leaves. The chemical structure and the absolute configuration of 1 were determined by MS, NMR and electron circular dichroism (ECD) experiments. The isolated compounds were evaluated for their antiproliferative activities against a panel of human tumor cell lines, including a multidrug-resistant (MDR) cell line. Both compounds showed potent antiproliferative activities against all the tested cell lines with IC values of 5.4-11.4 µM. Their effects on cell viability were also tested using vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cells (HUVECs). Compound 1 inhibited VEGF-stimulated HUVEC proliferation in a dose-dependent manner. Based on these results, compound 1 could be a candidate for antitumor agent and inhibitor of angiogenesis.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Diterpenos Clerodânicos/farmacologia
Neovascularização Patológica/tratamento farmacológico
Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores
Vitex/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Diterpenos Clerodânicos/química
Diterpenos Clerodânicos/isolamento & purificação
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/metabolismo
Seres Humanos
Estrutura Molecular
Neovascularização Patológica/patologia
Relação Estrutura-Atividade
Fatores de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes, Clerodane); 0 (Vascular Endothelial Growth Factors)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c16-00775


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[PMID]:27889228
[Au] Autor:Prasad EM; Mopuri R; Islam MS; Kodidhela LD
[Ad] Endereço:Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515003, India. Electronic address: emaruthip@gmail.com.
[Ti] Título:Cardioprotective effect of Vitex negundo on isoproterenol-induced myocardial necrosis in wistar rats: A dual approach study.
[So] Source:Biomed Pharmacother;85:601-610, 2017 Jan.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Cardiovascular diseases (CVDs) are becoming the major cause of deaths worldwide, and their treatment demands novel therapeutic strategies. In this connection, we have identified p21 activated kinase 1 (PAK1) as a novel therapeutic target for the treatment of myocardial infarction (MI), where its expression is decreased when MI is induced with isoproterenol (ISO), which was brought back normal with pretreatment of Vitex negundo leaf ethanolic extract (VNE). These results were also supported by histopathological studies, cardiac markers, antioxidants, and inflammatory cytokines (NF-κB and IL-1ß). Further studies with GC-MS analysis of VNE and in silico experiments confirmed 5,7-dihydroxy-6,4',-dimethoxy flavonone and 3',5-dihydroxy-6,7,4',-trimethoxyflavone are responsible for either maintaining or inducing the expression of PAK1 to protect from MI. Our findings for the first time revealed the use of phytoconstituents in the treatment of MI.
[Mh] Termos MeSH primário: Cardiopatias/induzido quimicamente
Necrose/induzido quimicamente
Extratos Vegetais/uso terapêutico
Vitex/química
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Regulação da Expressão Gênica/efeitos dos fármacos
Cardiopatias/tratamento farmacológico
Modelos Moleculares
Necrose/tratamento farmacológico
Extratos Vegetais/química
Conformação Proteica
Ratos
Ratos Wistar
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Quinases Ativadas por p21/genética
Quinases Ativadas por p21/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); EC 2.7.11.1 (Pak1 protein, rat); EC 2.7.11.1 (p21-Activated Kinases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE


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[PMID]:27830592
[Au] Autor:Li YT; Li MM; Sun J; Zhu ZX; Song YL; Pang DR; Zheng J; Zhao YF; Tu PF; Li J
[Ad] Endereço:a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
[Ti] Título:Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia.
[So] Source:Nat Prod Res;31(8):918-924, 2017 Apr.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3-6), were isolated from the leaves of Vitex negundo var. cannabifolia. The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC value of 69.1 ± 5.8 µM.
[Mh] Termos MeSH primário: Glucosídeos/farmacologia
Lignanas/química
Vitex/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Avaliação Pré-Clínica de Medicamentos/métodos
Glucosídeos/química
Glucosídeos/isolamento & purificação
Concentração Inibidora 50
Lignanas/farmacologia
Lipopolissacarídeos/farmacologia
Camundongos
Microglia/efeitos dos fármacos
Microglia/metabolismo
Estrutura Molecular
Óxido Nítrico/biossíntese
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucosides); 0 (Lignans); 0 (Lipopolysaccharides); 0 (cannabilignin); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1255887



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