Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.640 [Categoria DeCS]
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[PMID]:29378653
[Au] Autor:Kalyana Sundaram I; Sarangi DD; Sundararajan V; George S; Sheik Mohideen S
[Ad] Endereço:Department of Biotechnology, Dayanandasagar College of Engineering, Kumaraswamy Layout, Bangalore, 560078, Karnataka, India.
[Ti] Título:Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging.
[So] Source:BMC Complement Altern Med;18(1):33, 2018 Jan 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the skin. Extrinsic factors that affect skin aging such as UV radiation can also cause malignant melanoma. Here we selected four medicinal plant materials, namely, leaves of Nyctanthes arbor-tristis, unripe and ripe Aegle marmelos fruit pulp and the terminal meristem of Musa paradisiaca flower and investigated their anti-aging properties and cytotoxicity in vitro individually as well as in a poly herbal formulation containing the four plant extracts in different ratios. METHODS: The phytochemical contents of the plant extracts were investigated for radical scavenging activity and total reducing power. Based upon its anti-oxidant properties, a poly herbal formulation containing leaves of Nyctanthes arbor-tristis, unripe and ripe fruit pulp of Aegle marmelos, and the terminal meristem of Musa paradisiaca flower in the ratio 6:2:1:1 (Poly Herbal Formulation 1) and 1:1:1:1 (Poly Herbal Formulation 2), respectively were formulated. RESULT: It has been observed that the Poly Herbal Formulation 1 was more potent than Poly Herbal Formulation 2 due to better anti-oxidant and anti-elastase activities in NIH3T3 fibroblast cells. In addition Poly Herbal formulation 1 also had better anti-cancer activity in human malignant melanoma cells. CONCLUSION: Based on these results these beneficial plant extracts were identified for its potential application as an anti-aging agent in skin creams as well as an anti-proliferation compound against cancer cells.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Elastase Pancreática/antagonistas & inibidores
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Aegle/química
Animais
Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Camundongos
Células NIH 3T3
Óxido Nítrico/metabolismo
Oleaceae/química
Plantas Medicinais/química
Espécies Reativas de Oxigênio/metabolismo
Envelhecimento da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 31C4KY9ESH (Nitric Oxide); EC 3.4.21.36 (Pancreatic Elastase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2097-9


  2 / 215 MEDLINE  
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[PMID]:29224349
[Au] Autor:Liao X; Hu F; Chen Z
[Ad] Endereço:Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and Wuhan University School of Pharmaceutical Sciences , Wuhan 430071, China.
[Ti] Título:Identification and Quantitation of the Bioactive Components in Osmanthus fragrans Fruits by HPLC-ESI-MS/MS.
[So] Source:J Agric Food Chem;66(1):359-367, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Information on the chemical composition of Osmanthus fragrans fruits is still limited because there are many compounds present in low concentrations in the plant. In this work, the bioactive components in O. fragrans fruit extract were investigated by a new high-performance liquid chromatography electrospray ionization tandem mass spectrometry method, which allows sensitive analysis both in identification and quantitation. A total of 28 compounds were tentatively identified, and 16 components were discovered in O. fragrans fruits for the first time. The validated quantitative methods for the determination of the bioactive components were subsequently applied to analyze batches of O. fragrans fruits from different cultivars, which is beneficial for the comprehensive utilization of O. fragrans fruits.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Frutas/química
Oleaceae/química
Extratos Vegetais/química
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05560


  3 / 215 MEDLINE  
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[PMID]:29199255
[Au] Autor:Tanahashi T
[Ad] Endereço:Kobe Pharmaceutical University.
[Ti] Título:[Diversity of Secondary Metabolites from Some Medicinal Plants and Cultivated Lichen Mycobionts].
[So] Source:Yakugaku Zasshi;137(12):1443-1482, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Studies on the structural determination, biosynthesis, and biological activities of secondary metabolites from natural sources are significant in the field of natural products chemistry. This review focuses on diverse secondary metabolites isolated from medicinal plants and cultivated mycobionts of lichens in our laboratory. Monoterpene-tetrahydroisoquinoline glycosides and alkaloids isolated from Cephaelis acuminata and Alangium lamarckii gave important information on the biosynthesis of ipecac alkaloids. A variety of glycosides linked with a secologanin unit and indole alkaloids were obtained from medicinal plants belonging to the families of Rubiaceae, Apocynaceae, and Loganiaceae. Plant species of the four genera Fraxinus, Syringa, Jasminum, and Ligustrum of the family Oleaceae were chemically investigated to provide several types of secoiridoid and iridoid glucosides. The biosynthetic pathway leading from protopine to benzophenanthridine alkaloids in suspension cell cultures of Eschscholtzia californica was elucidated. The structures and biological activities of the bisbenzylisoquinoline alkaloids of Stephania cepharantha and Nelumbo nucifera were also investigated. In addition, the mycobionts of lichens were cultivated to afford various types of metabolites that differ from the lichen substances of intact lichens but are structurally similar to fungal metabolites. The biosynthetic origins of some metabolites were also studied. These findings suggest that cultures of lichen mycobionts could be sources of new bioactive compounds and good systems for investigating secondary metabolism in lichens.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Glicosídeos/isolamento & purificação
Líquens/metabolismo
Plantas Medicinais/metabolismo
[Mh] Termos MeSH secundário: Alangiaceae/metabolismo
Alcaloides/biossíntese
Alcaloides/química
Benzilisoquinolinas
Cephaelis/metabolismo
Eschscholzia/metabolismo
Glicosídeos/biossíntese
Glicosídeos/química
Iridoides
Monoterpenos
Oleaceae/metabolismo
Rubiaceae/metabolismo
Stephania/metabolismo
Tetra-Hidroisoquinolinas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Glycosides); 0 (Iridoids); 0 (Monoterpenes); 0 (Tetrahydroisoquinolines); 56W89FBX3E (1,2,3,4-tetrahydroisoquinoline)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00147


  4 / 215 MEDLINE  
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[PMID]:28502749
[Au] Autor:Mas S; Oeo-Santos C; Cuesta-Herranz J; Díaz-Perales A; Colás C; Fernández J; Barber D; Rodríguez R; de Los Ríos V; Barderas R; Villalba M
[Ad] Endereço:Dpto. Bioquímica y Biología Molecular I, Universidad Complutense de Madrid, Madrid, Spain.
[Ti] Título:A relevant IgE-reactive 28kDa protein identified from Salsola kali pollen extract by proteomics is a natural degradation product of an integral 47kDa polygalaturonase.
[So] Source:Biochim Biophys Acta;1865(8):1067-1076, 2017 08.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A highly prevalent IgE-binding protein band of 28kDa is observed when Salsola kali pollen extract is incubated with individual sera from Amaranthaceae pollen sensitized patients. By an immunoproteomic analysis of S. kali pollen extract, we identified this protein band as an allergenic polygalacturonase enzyme. The allergen, named Sal k 6, exhibits a pI of 7.14 and a molecular mass of 39,554.2Da. It presents similarities to Platanaceae, Poaceae, and Cupressaceae allergenic polygalacturonases. cDNA-encoding sequence was subcloned into the pET41b vector and produced in bacteria as a His-tag fusion recombinant protein. The far-UV CD spectrum determined that rSal k 6 was folded. Immunostaining of the S. kali pollen protein extract with a rSal k 6-specific pAb and LC-MS/MS proteomic analyses confirmed the co-existence of the 28kDa band together with an allergenic band of about 47kDa in the pollen extract. Therefore, the 28kDa was assigned as a natural degradation product of the 47kDa integral polygalacturonase. The IgE-binding inhibition to S. kali pollen extract using rSal k 6 as inhibitor showed that signals directed to both protein bands of 28 and 47kDa were completely abrogated. The average prevalence of rSal k 6 among the three populations analyzed was 30%, with values correlating well with the levels of grains/m of Amaranthaceae pollen. Sal k 6 shares IgE epitopes with Oleaceae members (Fraxinus excelsior, Olea europaea and Syringa vulgaris), with IgE-inhibition values ranging from 20% to 60%, respectively. No IgE-inhibition was observed with plant-derived food extracts.
[Mh] Termos MeSH primário: Antígenos de Plantas/metabolismo
Glicosídeos/metabolismo
Imunoglobulina E/metabolismo
Proteínas de Plantas/metabolismo
Pólen/metabolismo
Salsola/metabolismo
[Mh] Termos MeSH secundário: Amaranthaceae/química
Amaranthaceae/metabolismo
Sequência de Aminoácidos
Antígenos de Plantas/química
Sequência de Bases
Clonagem Molecular/métodos
Reações Cruzadas/fisiologia
Glicosídeos/química
Oleaceae/química
Oleaceae/metabolismo
Proteínas de Plantas/química
Pólen/química
Ligação Proteica/fisiologia
Proteômica/métodos
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/metabolismo
Salsola/química
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, Plant); 0 (Glycosides); 0 (Plant Proteins); 0 (Recombinant Fusion Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


  5 / 215 MEDLINE  
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[PMID]:28282901
[Au] Autor:Fu J; Hou D; Zhang C; Bao Z; Zhao H; Hu S
[Ad] Endereço:Department of Ornamental Horticulture, School of Landscape Architecture, Zhejiang Agriculture and Forestry University, Lin'an 311300, China. fujianxin2008@sohu.com.
[Ti] Título:The Emission of the Floral Scent of Four Osmanthus fragrans Cultivars in Response to Different Temperatures.
[So] Source:Molecules;22(3), 2017 Mar 08.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Floral scent is an important part of volatile organic compounds (VOCs) emitted from plants, and is influenced by many environmental and endogenous factors. To investigate the influence of temperature on the emission of the floral scent of , the number of chemical compounds and their relative release amounts from four cultivars of under different temperature treatments, were identified using the solid-phase microextraction (SPME) technique and gas chromatography-mass spectrometry (GC-MS) in this study. Results revealed that the numbers and release amounts of floral scent components were significantly influenced by different temperatures, and depend on different cultivars and different types of compounds. Overall, most cultivars had the largest number of chemical compounds in 19 °C and the numbers of chemical compounds decreased with the increase or decrease in the temperature. Alcohols and ketones were the two main kinds of compounds responding to temperature change. The response of a specific chemical compound to temperature change was different in four cultivars. Generally, linalool, α-ionone, ß-ionone, and γ-decalactone accounted for the highest proportion in the nine main compounds, and changes of these four chemical compounds to different temperatures had obvious contributions to the floral scent of . The results obtained provide evidence that temperatures can greatly influence the emission of floral scent.
[Mh] Termos MeSH primário: Oleaceae/química
Temperatura Ambiente
Compostos Orgânicos Voláteis/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Compostos Fitoquímicos/química
Microextração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


  6 / 215 MEDLINE  
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[PMID]:28078388
[Au] Autor:Mesléard F; Yavercovski N; Lefebvre G; Willm L; Bonis A
[Ad] Endereço:Institut de recherche de la Tour du Valat, Le Sambuc, Arles, 13200, France. mesleard@tourduvalat.org.
[Ti] Título:High Stocking Density Controls Phillyrea Angustifolia in Mediterranean Grasslands.
[So] Source:Environ Manage;59(3):455-463, 2017 Mar.
[Is] ISSN:1432-1009
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Extensive grazing applied in the form of low instantaneous pressure over a long period is a widespread management practice in protected areas. However this kind of stocking method does not always achieve the expected results, in particular because it fails to limit colonization by woody plants.This is the case in the relict xero-halophytic grasslands of the northern Mediterranean coastal region, subjected to widespread colonization by the shrub Phillyrea angustifolia despite the presence of extensive grazing. In this study, we investigated, for an equal annual stocking rate, the respective impact of high stocking density applied over a short period (mob grazing) and low stocking density applied over a long period on both P. angustifolia and herbaceous cover, using an in situ experimental design run for 7 years. Only mob grazing was effective both in controlling the establishment and increasing the mortality of P. angustifolia individuals. We did not find any difference after the 7 years of experimentation between the two stocking methods with regard to the herbaceous community parameters tested: species richness, diversity, evenness, contribution of annual characteristic species. By contrast, the exclusion of domestic grazing led to a strong reduction of these values.The use of mob grazing may be well suited for meeting conservation goals such as maintaining open habitats in these grasslands.
[Mh] Termos MeSH primário: Ecossistema
Pradaria
Herbivoria
Oleaceae/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Biodiversidade
Região do Mediterrâneo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1007/s00267-016-0808-x


  7 / 215 MEDLINE  
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[PMID]:28031427
[Au] Autor:Peterson DL; Cipollini D
[Ad] Endereço:Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Highway, 203 Biological Sciences I, Dayton, OH 45435 (peterson.143@wright.edu; don.cipollini@wright.edu).
[Ti] Título:Distribution, Predictors, and Impacts of Emerald Ash Borer (Agrilus planipennis) (Coleoptera: Buprestidae) Infestation of White Fringetree (Chionanthus virginicus).
[So] Source:Environ Entomol;46(1):50-57, 2017 02 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Emerald ash borer, Agrilus planipennis (Fairmaire), is an invasive pest of ash trees (Fraxinus spp.) in North America that was recently found infesting white fringetree (Chionanthus virginicus L.). Initial reports of the infestation of white fringetree by emerald ash borer occurred in southwestern Ohio and Chicago, IL. We examined white fringetrees at additional sites in Illinois, Indiana, Ohio, and Pennsylvania in Summer and Fall 2015 and Winter 2016 for emerald ash borer infestation. Our aim was to examine white fringetrees at a limited number of sites with emerald ash borer infestation and to relate tree size, crown dieback, epicormic sprouting, tree sex, and adjacency to ash or white fringetrees with the likelihood of beetle infestation. A higher proportion of infested trees exhibited epicormic sprouting and the likelihood that a tree was infested increased with increasing crown dieback, variables that may be both predictors and responses to attack. The proportion of trees infested with emerald ash borer increased with increasing tree size. Signs consistent with emerald ash borer infestation were found in 26% of 178 white fringetrees, with at least one host infested at each site in all states. Infestation rates of white fringetrees increased with the density of white fringetrees at each site. The Chicago Botanic Garden site had a significantly lower infestation (3.7%) than other sites, which may be due to proactive management of ash. Overall, these data indicate white fringetree has been utilized by emerald ash borer throughout their overlapping ranges in the United States in ornamental settings likely due to ecological fitting.
[Mh] Termos MeSH primário: Coleópteros/fisiologia
Cadeia Alimentar
Espécies Introduzidas
Oleaceae/parasitologia
[Mh] Termos MeSH secundário: Animais
Comportamento Alimentar
Larva
Meio-Oeste dos Estados Unidos
Oleaceae/crescimento & desenvolvimento
Pennsylvania
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvw148


  8 / 215 MEDLINE  
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[PMID]:27997755
[Au] Autor:Venditti A; Frezza C; Foddai S; Serafini M; Nicoletti M; Bianco A
[Ad] Endereço:Department of Chemistry, University of Roma 'La Sapienza', Piazzale Aldo Moro 5, 00185, Roma, Italy.
[Ti] Título:Chemical Traits of Hemiparasitism in Odontites luteus.
[So] Source:Chem Biodivers;14(4), 2017 Apr.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The study of the monoterpene glycosides content of Odontites luteus has shown the presence of a total of fifteen iridoid glucosides. The presence of compounds 1 - 5 and 7 - 10 is perfectly on-line with both the biogenetic pathway for iridoids biosynthesis in Lamiales and the current botanical classification of the species. On the other side, the presence of compounds like agnuside (6), adoxosidic acid (11), monotropein (12), 6,7-dihydromonotropein (13), methyl oleoside (14) and methyl glucooleoside (15) is of high interest because, first of all, they have never been reported before in Lamiales. In second instance, the majority of the last compounds are formally derived from a different biogenetic pathway which involves deoxyloganic acid/loganin and led to the formation of decarboxylated iridoid showing the 8ß-configuration. Furthermore, a second abnormality was found during our study and this regards compounds 14 and 15 which are seco-iriodids and thus not typical for this family. The presence of these unusual compounds, biogenetically not related to species belonging to Lamiales, is a clear evidence of the metabolites transfer from the hosts. In fact, the collection area is also populated by species belonging to Oleaceae and Ericaceae which could be the possible hosts since the biosynthesis of seco-iridoids and or iridoids related to deoxyloganic acid/loganin pathway, with the 8ß-configuration, is well documented in these species.
[Mh] Termos MeSH primário: Iridoides/química
Orobanchaceae/química
[Mh] Termos MeSH secundário: Animais
Ericaceae/química
Ericaceae/metabolismo
Glicosídeos
Redes e Vias Metabólicas
Metabolômica
Monoterpenos
Oleaceae/química
Oleaceae/metabolismo
Orobanchaceae/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Iridoids); 0 (Monoterpenes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600416


  9 / 215 MEDLINE  
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[PMID]:27664663
[Au] Autor:Zhou F; Peng J; Zhao Y; Huang W; Jiang Y; Li M; Wu X; Lu B
[Ad] Endereço:Zhejiang University, College of Biosystems Engineering and Food Science, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang R & D Center for Food Technology and Equipment, Key Laboratory for Agro-Food Risk Assessment of Ministry of Agriculture, Hangzhou 31
[Ti] Título:Varietal classification and antioxidant activity prediction of Osmanthus fragrans Lour. flowers using UPLC-PDA/QTOF-MS and multivariable analysis.
[So] Source:Food Chem;217:490-497, 2017 Feb 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was aimed to classify the varieties and predict the antioxidant activity of Osmanthus fragrans flowers by UPLC-PDA/QTOF-MS and multivariable analysis. The PLS-DA model successfully classified the four varieties based on both the 21 identified compounds and the effective compounds. For the antioxidant activity prediction, PLS performed well to predict the antioxidant activity of O. fragrans flowers. Furthermore, acteoside, suspensaside A, ligustroside, forsythoside A, phillygenin and caffeic acid were selected as effective compounds by UVE-SPA for prediction. On the basis of effective compounds, PLS, MLR and PCR were applied to establish the calibration models. The UVE-SPA-MLR model was the optimal method to predict the antioxidant activity values with Rp of 0.9200, 0.9010 and 0.8905 for DPPH, ABTS and FRAP assays, respectively. The results revealed that the UPLC-PDA/QTOF-MS combined with chemometrics could be a new method to classify the varieties and predict the antioxidant activity of O. fragrans flowers.
[Mh] Termos MeSH primário: Flores/química
Oleaceae/química
[Mh] Termos MeSH secundário: Ácidos Cafeicos/análise
Glucosídeos/análise
Lignanas/análise
Espectrometria de Massas
Modelos Teóricos
Fenóis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caffeic Acids); 0 (Glucosides); 0 (Lignans); 0 (Phenols); 0 (phillygenin); 3TGX09BD5B (acteoside); 84213-44-5 (suspensaside)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


  10 / 215 MEDLINE  
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[PMID]:28174794
[Au] Autor:Berbecaru-Iovan A; Stanciulescu EC; Andrei AM; Berbecaru-Iovan S; Gîrd CE; Dumitrescu CI; BaniTa IM; Pisoschi CG
[Ad] Endereço:Department of Biochemistry, University of Medicine and Pharmacy of Craiova, Romania; camiparsot@yahoo.com.
[Ti] Título:Hepatoprotective effect of Syringae vulgaris flos ethanolic extracts in streptozotocin-induced diabetes in rats.
[So] Source:Rom J Morphol Embryol;57(4):1279-1284, 2016.
[Is] ISSN:1220-0522
[Cp] País de publicação:Romania
[La] Idioma:eng
[Ab] Resumo:Taking account of increasing world population life expectancy, health services will face with a large number of elderly people with chronic age-related diseases. It has been established that chronic diseases are usually accompanied by oxidative stress induced by the overproduction of reactive oxygen species damaging cellular constituents, under conditions of weakening antioxidant defense systems. The balance between free radicals and antioxidant endogenous systems has a defining role in preventing the damage of macromolecules. In addition to the enzymatic (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase) and non-enzymatic (vitamins A, C, E) endogenous systems, a good source of natural antioxidants are medicinal herbs products or phytochemical compounds. The aim of this study is to evaluate the hepatoprotective effect of Syringae vulgaris flos ethanolic extracts in a rat model of streptozotocin-induced diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Fígado/efeitos dos fármacos
Oleaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/metabolismo
Etanol/química
Fígado/metabolismo
Masculino
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE



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