Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.640.833 [Categoria DeCS]
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[PMID]:28890377
[Au] Autor:Wang Y; Dou Y; Wang R; Guan X; Hu Z; Zheng J
[Ad] Endereço:College of Landscape Architecture, Beijing University of Agriculture, Beijing 102206, China.
[Ti] Título:Molecular characterization and functional analysis of chalcone synthase from Syringa oblata Lindl. in the flavonoid biosynthetic pathway.
[So] Source:Gene;635:16-23, 2017 Nov 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The flower color of Syringa oblata Lindl., which is often modulated by the flavonoid content, varies and is an important ornamental feature. Chalcone synthase (CHS) catalyzes the first key step in the flavonoid biosynthetic pathway. However, little is known about the role of S. oblata CHS (SoCHS) in flavonoid biosynthesis in this species. Here, we isolate and analyze the cDNA (SoCHS1) that encodes CHS in S. oblata. We also sought to analyzed the molecular characteristics and function of flavonoid metabolism by SoCHS1. We successfully isolated the CHS-encoding genomic DNA (gDNA) in S. oblata (SoCHS1), and the gene structural analysis indicated it had no intron. The opening reading frame (ORF) sequence of SoCHS1 was 1170bp long and encoded a 389-amino acid polypeptide. Multiple sequence alignment revealed that both the conserved CHS active site residues and CHS signature sequence were in the deduced amino acid sequence of SoCHS1. Crystallographic analysis revealed that the protein structure of SoCHS1 is highly similar to that of FnCHS1 in Freesia hybrida. The quantitative real-time polymerase chain reaction (PCR) performed to detect the SoCHS1 transcript expression levels in flowers, and other tissues revealed the expression was significantly correlated with anthocyanin accumulation during flower development. The ectopic expression results of Nicotiana tabacum showed that SoCHS1 overexpression in transgenic tobacco changed the flower color from pale pink to pink. In conclusion, these results suggest that SoCHS1 plays an essential role in flavonoid biosynthesis in S. oblata, and could be used to modify flavonoid components in other plant species.
[Mh] Termos MeSH primário: Aciltransferases/genética
Vias Biossintéticas
Flavonoides/metabolismo
Flores/genética
[Mh] Termos MeSH secundário: Aciltransferases/biossíntese
Sequência de Aminoácidos/genética
Antocianinas/metabolismo
Clonagem Molecular
Flavonoides/genética
Flores/crescimento & desenvolvimento
Regulação da Expressão Gênica de Plantas
Alinhamento de Sequência
Syringa/enzimologia
Syringa/genética
Tabaco/genética
Tabaco/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Flavonoids); EC 2.3.- (Acyltransferases); EC 2.3.1.74 (flavanone synthetase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE


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[PMID]:28728914
[Au] Autor:Dudek MK; Michalak B; Wozniak M; Czerwinska ME; Filipek A; Granica S; Kiss AK
[Ad] Endereço:Centre of Molecular and Macromolecular Studies of Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
[Ti] Título:Hydroxycinnamoyl derivatives and secoiridoid glycoside derivatives from Syringa vulgaris flowers and their effects on the pro-inflammatory responses of human neutrophils.
[So] Source:Fitoterapia;121:194-205, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Thirteen new compounds including caffeoyl-glucaric and p-coumaroyl-altraric acid derivatives, one monoterpenoid glucoside, four secoiridoid glycosides, and three hydroxycinnamoyl phenylpropanoid glycosides esterified with an oleoside 11-methyl ester along with fifteen known compounds were isolated from flowers of Syringa vulgaris L. (Oleaceae). Their structures were elucidated by high-resolution spectroscopic methods. The tested compounds were able to decrease the production of reactive oxygen species. Moreover, oleoechinacoside (13), demethylhydroxyoleonuezhenide (14), demethyloleonuezhenide (15), syringaoleoacteoside (25) and oleoacteoside (26) at the concentration of 50µM, moderately suppressed the LPS-stimulated release of pro-inflammatory chemokine IL-8 and TNF-α from human neutrophils. Moreover, oleonuezhenide (12), oleoside 11-methyl ester (16) and oleoacteoside (26) at the concentration of 50µM were able to induce the surface expression of interleukin 10 receptor, which is suppressed by the incubation of monocyte/macrophage cells with LPS.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Flores/química
Glicosídeos Iridoides/farmacologia
Neutrófilos/efeitos dos fármacos
Syringa/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/isolamento & purificação
Células Cultivadas
Glucosídeos/isolamento & purificação
Glucosídeos/farmacologia
Glicosídeos
Seres Humanos
Interleucina-8/metabolismo
Glicosídeos Iridoides/isolamento & purificação
Macrófagos/efeitos dos fármacos
Estrutura Molecular
Extratos Vegetais/química
Receptores de Interleucina-10/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Glucosides); 0 (Glycosides); 0 (IL8 protein, human); 0 (Interleukin-8); 0 (Iridoid Glycosides); 0 (Plant Extracts); 0 (Receptors, Interleukin-10); 0 (Tumor Necrosis Factor-alpha); 0 (oleoacteoside); 0 (oleoechinacoside)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE


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[PMID]:28381676
[Au] Autor:Park KJ; Suh WS; Subedi L; Kim SY; Choi SU; Lee KR
[Ad] Endereço:Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University.
[Ti] Título:Secoiridoid Glucosides from the Twigs of Syringa oblata var. dilatata and Their Neuroprotective and Cytotoxic Activities.
[So] Source:Chem Pharm Bull (Tokyo);65(4):359-364, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the twigs of Syringa oblata var. diatata led to the isolation of two new secoiridoid glucosides, dilatioside A-B (1-2), along with thirteen known ones (3-15). The structures were determined by spectroscopic methods including one and two dimensional (1- and 2D-) NMR techniques, high resolution (HR)-FAB-MS, and chemical methods. The isolated compounds (1-15) were tested for the induction of nerve growth factor (NGF) secretion in a C6 rat glioma cell line and their cytotoxicity against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, HCT15) in vitro using a sulforhodamine B bioassay. Compounds 5, 7, 8, 10, and 14 were found to induce upregulation of NGF secretion without causing significant cell toxicity.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Glucosídeos Iridoides/farmacologia
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
Syringa/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Glucosídeos Iridoides/química
Glucosídeos Iridoides/isolamento & purificação
Conformação Molecular
Fatores de Crescimento Neural/metabolismo
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/isolamento & purificação
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Caules de Planta/química
Ratos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Iridoid Glucosides); 0 (Nerve Growth Factors); 0 (Neuroprotective Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c16-00804


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[PMID]:28367639
[Au] Autor:Zhang RF; Feng X; Su GZ; Yin X; Yang XY; Zhao YF; Li WF; Tu PF; Chai XY
[Ad] Endereço:a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.
[Ti] Título:Noralashinol B, a norlignan with cytotoxicity from stem barks of Syringa pinnatifolia.
[So] Source:J Asian Nat Prod Res;19(4):416-422, 2017 Apr.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One new norlignan, noralashinol B (1), and one new natural product, proposed noralashinol C (2), were isolated in a continuous phytochemical investigation on the stem barks of Syringa pinnatifolia. Their structures were elucidated based on the analysis of spectroscopic data, including mass spectrometry and 1D and 2D NMR spectroscopies, and the absolute configuration was determined by experimental and calculated electronic circular dichroism. Compound 1 showed a weak cytotoxicity against HepG2 hepatic cancer cells with its IC value of 31.7 µM. Furthermore, 1 induced apoptosis of HepG2 cells in a dose-dependent manner at concentrations of 0-80.0 µM.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Lignanas/isolamento & purificação
Lignanas/farmacologia
Syringa/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Células Hep G2
Seres Humanos
Concentração Inibidora 50
Lignanas/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Casca de Planta/química
Caules de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Lignans); 0 (noralashinol B)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2017.1307188


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[PMID]:28278677
[Au] Autor:D'Auria M; Lorenz R; Racioppi R; Romano VA
[Ad] Endereço:a Dipartimento di Scienze , Università della Basilicata , Potenza , Italy.
[Ti] Título:Fragrance components of Platanthera bifolia subsp. osca.
[So] Source:Nat Prod Res;31(14):1612-1619, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:SPME-GC-MS analysis of the scent of Platanthera bifolia subsp. osca collected during the night showed as main components lilac alcohols B, C and D and lilac aldehydes A, B and C. Other significant chemical components were linalool and caryophyllene. Some differences were found in comparison with previously reported analyses of the scent of P. bifolia and Platanthera chlorantha. The most important difference found was in the composition of the ester fraction.
[Mh] Termos MeSH primário: Odorantes/análise
Orchidaceae/química
Syringa/química
[Mh] Termos MeSH secundário: Álcoois/análise
Aldeídos/análise
Cromatografia Gasosa-Espectrometria de Massas
Monoterpenos/análise
Sesquiterpenos/análise
Microextração em Fase Sólida/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols); 0 (Aldehydes); 0 (Monoterpenes); 0 (Sesquiterpenes); BHW853AU9H (caryophyllene); D81QY6I88E (linalool)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1289203


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[PMID]:28152612
[Au] Autor:Feng X; Su G; Ye Y; Zhang R; Yang X; Du B; Peng B; Tu P; Chai X
[Ad] Endereço:a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , People's Republic of China.
[Ti] Título:Alashinols F and G, two lignans from stem bark of Syringa pinnatifolia.
[So] Source:Nat Prod Res;31(13):1555-1560, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new lignans, alashinols F and G (1 and 2), together with two known analogues (-)-secoisolariciresinol (3) and meso-secoisolariciresinol (4) were isolated from the stem bark of Syringa pinnatifolia, a Mongolian folk medicine with anti-myocardial ischaemic effects. Their structures were elucidated on basis of spectroscopic data analyses, including MS and 1D and 2D NMR, and their absolute configurations were elucidated on the basis of experimental and calculated electronic circular dichroisms. The in vitro anti-inflammation and anti-hypoxia evaluations were also discussed.
[Mh] Termos MeSH primário: Lignanas/isolamento & purificação
Casca de Planta/química
Syringa/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Butileno Glicóis/isolamento & purificação
Hipóxia/tratamento farmacológico
Lignanas/química
Lignanas/farmacologia
Espectroscopia de Ressonância Magnética
Medicina Tradicional da Mongólia
Estrutura Molecular
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Butylene Glycols); 0 (Lignans); M8QRJ7JEJH (secoisolariciresinol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1283500


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[PMID]:27914543
[Au] Autor:Bai W; Kong F; Lin Y; Zhang C
[Ad] Endereço:Pest Integrated Management Key Laboratory of China Tobacco, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, China; Tobacco Research Institute of Nanping, Nangping, China.
[Ti] Título:Extract of Syringa oblata: A new biocontrol agent against tobacco bacterial wilt caused by Ralstonia solanacearum.
[So] Source:Pestic Biochem Physiol;134:79-83, 2016 Nov.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ralstonia solanacearum causes serious wilt disease in tobacco. To effectively control this disease, the antibacterial activity of 95% ethanol extracts from the flower buds of Syringa oblata was examined. Based on GC-MS analysis and an inhibition experiment against R. solanacearum, the main antibacterial component is eugenol. We further determined the effect of eugenol on the physiology, biochemistry, and cellular morphology of R. solanacearum. The results showed that eugenol can destroy wilt bacteria, leading to the disappearance of flagella, the leakage of contents, and the appearance of a cavity. SDS-PAGE showed that eugenol decreased protein content in R. solanacearum, reduced medium carbohydrate utilization, and inhibited CAT and SDH activity. The above results showed that eugenol had a significant inhibitory effect on R. solanacearum and this component has the potential to prevent tobacco bacterial wilt.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Eugenol/farmacologia
Doenças das Plantas/prevenção & controle
Extratos Vegetais/farmacologia
Ralstonia solanacearum/efeitos dos fármacos
Syringa
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Proteínas de Bactérias/metabolismo
Catalase/metabolismo
Flores
Microscopia Eletrônica de Transmissão
Controle Biológico de Vetores
Extratos Vegetais/química
Ralstonia solanacearum/crescimento & desenvolvimento
Ralstonia solanacearum/metabolismo
Ralstonia solanacearum/ultraestrutura
Succinato Desidrogenase/metabolismo
Tabaco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Plant Extracts); 3T8H1794QW (Eugenol); EC 1.11.1.6 (Catalase); EC 1.3.99.1 (Succinate Dehydrogenase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


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[PMID]:27568323
[Au] Autor:Su G; Zhang R; Yang X; Bai R; Yin X; Gao X; Li L; Tu P; Chai X
[Ad] Endereço:Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China.
[Ti] Título:Lignans from the stem bark of Syringa pinnatifolia.
[So] Source:Fitoterapia;114:63-68, 2016 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Four new lignans, alashinols A-D (1-4), a new hydrolysis product, alashinols E (5), and seven known analogues were isolated from the stem bark of Syringa pinnatifolia Hemsl. These new lignans were characterized using 1D and 2D NMR and MS data, and their absolute configurations were determined by experimental and calculated electronic circular dichroism and X-ray diffraction analyses. Alashinol B (2) exhibited two conformers that adopted an unusual unit cell packing. Anti-inflammatory evaluation revealed that compounds 1, 4, 6, and 8 showed moderate inhibition against NO production in lipopolysaccharide-induced macrophages RAW 264.7 cells with IC values range from 43.3-60.9µM, and 1 decreased the TNF-α and IL-6 level in a concentration-dependent manner at 40-160µM and exhibited considerable neuroprotective effect against the glutamate-induced injury in PC12 cell line. Analogues 3 and 9 showed protective effects against oxygen glucose deprivation/reoxygenation in H9c2 cells.
[Mh] Termos MeSH primário: Lignanas/química
Casca de Planta/química
Syringa/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Interleucina-6/metabolismo
Lignanas/isolamento & purificação
Camundongos
Estrutura Molecular
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/isolamento & purificação
Estresse Oxidativo/efeitos dos fármacos
Células PC12
Extratos Vegetais/química
Células RAW 264.7
Ratos
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Interleukin-6); 0 (Lignans); 0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160829
[St] Status:MEDLINE


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[PMID]:27130642
[Au] Autor:Cao Y; Wang J; Su G; Wu Y; Bai R; Zhang Q; Gao X; Li C; Chen S; Tu P; Chai X
[Ad] Endereço:Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, PR China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, PR China.
[Ti] Título:Anti-myocardial ischemia effect of Syringa pinnatifolia Hemsl. by inhibiting expression of cyclooxygenase-1 and -2 in myocardial tissues of mice.
[So] Source:J Ethnopharmacol;187:259-68, 2016 Jul 01.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The peeled stem of Syringa pinnatifolia Hemsl. (SP) is a traditional medicine in Inner Mongolia, China. The powder form of SP has been widely used for hundreds of years to relieve "He-Yi" related myocardial ischemia independently or in a traditional Chinese medicine preparation. MATERIALS AND METHODS: SP was extracted with 95% and 80% ethanol. Chemical profiling was performed using HPLC-DAD and IT-TOF-ESI-MS analyses. Myocardial ischemia was produced by ligation of the left anterior descending (LAD) coronary artery to evaluate the anti-myocardial ischemia effect of SP. Male C57BL/6 mice were randomly divided into six groups (n=10 per group): a sham group, a model group, groups pretreated with SP at three dosages (20mg/kg, 40mg/kg, and 80mg/kg, intragastrically), and a positive control group (acetylsalicylic acid, ASA, 53mg/kg, intragastrically). Echocardiography was performed to determine heart function by measuring ejection fraction and fractional shortening. The levels of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) in serum, and 6-keto-PGF1α and TXB2 both in plasma and in protein homogenate of myocardial tissue were also measured. The levels of cyclooxygenase (COX)-1 and -2 in the heart tissue and their expressions in mouse myocardial tissue were determined using Western blot and an immunofluorescence assay, respectively. Inflammatory cell infiltration and collagen deposition changes in the myocardial ischemic tissue were observed by pathological examination. RESULTS: Intragastric pretreatment with SP produced a dose-dependent increase in cardiac function. SP at 80mg/kg significantly improved the EF (p<0.001) and FS (p<0.01) compared with the model group, as well as the levels of serum CK-MB and LDH decreased obviously (p<0.001), approaching those in the sham group. Besides, an obvious reduction in inflammatory cells infiltration and collagen deposition in the infarcted myocardial tissue was shown in each SP treatment group. In addition, SP increased 6-keto-PGF1α and decreased TXB2 levels in the plasma, whereas the opposite pattern was observed in the protein homogenate from the myocardial tissues at the infarction edge, but keeping balance the ratio of 6-keto-PGF1α and TXB2, which is better than ASA in plasma. The mechanisms is associated with the downregulated expressions of COX-1 (p<0.05) and COX-2 (p<0.001). CONCLUSIONS: Ethanol extract of SP has a protective effect against myocardial ischemia via down regulation of COX-1 and COX-2 expression and by adjusting the ischemia-induced imbalance between 6-keto-PGF1α and TXB2. This study shows substantial evidence to support the clinical application of SP and indicates that such medicine has great potential for treating ischemia-induced heart disease.
[Mh] Termos MeSH primário: Inibidores de Ciclo-Oxigenase/uso terapêutico
Isquemia Miocárdica/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Syringa
[Mh] Termos MeSH secundário: 6-Cetoprostaglandina F1 alfa/sangue
6-Cetoprostaglandina F1 alfa/metabolismo
Animais
Creatina Quinase Forma MB/sangue
Ciclo-Oxigenase 1/metabolismo
Ciclo-Oxigenase 2/metabolismo
Inibidores de Ciclo-Oxigenase/farmacologia
L-Lactato Desidrogenase/sangue
Masculino
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Isquemia Miocárdica/sangue
Isquemia Miocárdica/metabolismo
Isquemia Miocárdica/patologia
Miocárdio/metabolismo
Miocárdio/patologia
Fitoterapia
Extratos Vegetais/farmacologia
Caules de Planta
Tromboxano B2/sangue
Tromboxano B2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclooxygenase Inhibitors); 0 (Membrane Proteins); 0 (Plant Extracts); 54397-85-2 (Thromboxane B2); 58962-34-8 (6-Ketoprostaglandin F1 alpha); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 1); EC 1.14.99.1 (Cyclooxygenase 2); EC 1.14.99.1 (Ptgs1 protein, mouse); EC 2.7.3.2 (Creatine Kinase, MB Form)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160501
[St] Status:MEDLINE


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[PMID]:26950674
[Au] Autor:Su G; Bai R; Yu X; Cao Y; Yin X; Tu P; Chai X
[Ad] Endereço:a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , China.
[Ti] Título:Noralashinol A, a new norlignan from stem barks of Syringa pinnatifolia.
[So] Source:Nat Prod Res;30(19):2149-53, 2016 Oct.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One new norlignan, namely noralashinol A (1), one known analogue (2), together with seven known lignans (3-9) were isolated from the stem barks of Syringa pinnatifolia. Their structures were elucidated extensively by spectroscopic methods, including mass spectrometry and 1D and 2D NMR spectroscopies. Compound 8 significantly inhibited NO production in LPS-induced BV-2 murine microglia cells with its IC50 value of 20.7 µM, compared to a positive control quercetin with its IC50 value of 15.3 µM.
[Mh] Termos MeSH primário: Naftóis/farmacologia
Syringa/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/isolamento & purificação
Anti-Inflamatórios não Esteroides/farmacologia
Células Cultivadas
Avaliação Pré-Clínica de Medicamentos/métodos
Concentração Inibidora 50
Lignanas/química
Lignanas/isolamento & purificação
Lignanas/farmacologia
Lipopolissacarídeos/farmacologia
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Camundongos
Microglia/efeitos dos fármacos
Estrutura Molecular
Naftóis/isolamento & purificação
Óxido Nítrico/biossíntese
Casca de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Lignans); 0 (Lipopolysaccharides); 0 (Naphthols); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1146886



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