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Pesquisa : B01.650.940.800.575.912.250.583.690.500 [Categoria DeCS]
Referências encontradas : 103 [refinar]
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  1 / 103 MEDLINE  
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[PMID]:28635142
[Au] Autor:Ferrante C; Recinella L; Locatelli M; Guglielmi P; Secci D; Leporini L; Chiavaroli A; Leone S; Martinotti S; Brunetti L; Vacca M; Menghini L; Orlando G
[Ad] Endereço:Department of Pharmacy, G. D'Annunzio University Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy.
[Ti] Título:Protective Effects Induced by Microwave-Assisted Aqueous Harpagophytum Extract on Rat Cortex Synaptosomes Challenged with Amyloid ß-Peptide.
[So] Source:Phytother Res;31(8):1257-1264, 2017 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Harpagophytum procumbens is a plant species that displays anti-inflammatory properties in multiple tissues. The iridoid glycosides arpagoside, harpagide, and procumbide appear to be the most therapeutically important constituents. In addition, harpagoside treatment exerted neuroprotective effects both in vitro and in vivo. Considering these findings, the aim of the present work is to explore the possible protective role of the previously described microwave-assisted aqueous extract of H. procumbens on rat hypothalamic (Hypo-E22) cells, and in rat cortex challenged with amyloid ß-peptide (1-40). In this context, we assayed the protective effects induced by H. procumbens by measuring the levels of malondialdehyde, 3-hydroxykynurenine (3-HK), brain-derived neurotrophic factor, and tumor necrosis factor-α, 3-HK. Finally, we evaluated the effects of H. procumbens treatment on cortex levels of dopamine, norepinephrine, and serotonin. H. procumbens extract was well tolerated by Hypo-E22 cells and upregulated brain-derived neurotrophic factor gene expression but down-regulated tumor necrosis factor-α gene expression. In addition, the extract reduced amyloid ß-peptide stimulation of malondialdehyde and 3-HK and blunted the decrease of dopamine, norepinephrine, and serotonin, in the cortex. In this context, our work supports further studies for the evaluation and confirmation of Harpagophytum in the management of the clinical symptoms related to Alzheimer's disease. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/farmacologia
Harpagophytum/química
Micro-Ondas
Extratos Vegetais/farmacologia
Sinaptossomos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Encéfalo/efeitos dos fármacos
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Células Cultivadas
Dopamina/metabolismo
Glicosídeos/farmacologia
Cinurenina/análogos & derivados
Cinurenina/metabolismo
Masculino
Malondialdeído/metabolismo
Norepinefrina/metabolismo
Raízes de Plantas/química
Piranos/farmacologia
Ratos
Ratos Sprague-Dawley
Serotonina/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Anti-Inflammatory Agents); 0 (Brain-Derived Neurotrophic Factor); 0 (Glycosides); 0 (Plant Extracts); 0 (Pyrans); 0 (Tumor Necrosis Factor-alpha); 27723548JL (3-hydroxykynurenine); 333DO1RDJY (Serotonin); 343-65-7 (Kynurenine); 4Y8F71G49Q (Malondialdehyde); 8KGS1DC5ZU (harpagoside); VTD58H1Z2X (Dopamine); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5850


  2 / 103 MEDLINE  
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[PMID]:28447368
[Au] Autor:Locatelli M; Ferrante C; Carradori S; Secci D; Leporini L; Chiavaroli A; Leone S; Recinella L; Orlando G; Martinotti S; Brunetti L; Vacca M; Menghini L
[Ad] Endereço:Department of Pharmacy, G. D'Annunzio University Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy.
[Ti] Título:Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model.
[So] Source:Phytother Res;31(6):937-944, 2017 Jun.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Harpagophytum procumbens has a long story of use for the treatment of inflammatory diseases. Considering both the antiinflammatory effects of H. procumbens in multiple tissues and the stability of harpagoside in artificial intestinal fluid, the aim of the present study was to explore the possible protective role of a microwave-assisted aqueous Harpagophytum extract (1-1000 µg/mL) on mouse myoblast C2C12 and human colorectal adenocarcinoma HCT116 cell lines, and isolated rat colon specimens challenged with lipopolysaccharide (LPS), a validated ex vivo model of acute ulcerative colitis. In this context, we evaluated the effects on C2C12 and HCT116 viability, and on LPS-induced production of serotonin (5-HT), tumor necrosis factor (TNF)-α, prostaglandin (PG)E and 8-iso-prostaglandin (8-iso-PG)F . Harpagophytum extract was well tolerated by C2C12 cells, while reduced HCT116 colon cancer cell viability. On the other hand, Harpagophytum extract reduced H O -induced (1 mM) reactive oxygen species (ROS) production, in both cell lines, and inhibited LPS-induced colon production of PGE , 8-iso-PGF , 5-HT and TNFα. Concluding, we demonstrated the efficacy of a microwave-assisted Harpagophytum aqueous extract in modulating the inflammatory, oxidative stress and immune response in an experimental model of inflammatory bowel diseases (IBD), thus suggesting a rational use of Harpagophytum in the management and prevention of ulcerative colitis in humans. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Colo/efeitos dos fármacos
Glicosídeos/farmacologia
Harpagophytum/química
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Piranos/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Dinoprosta/análogos & derivados
Dinoprosta/metabolismo
Dinoprostona/metabolismo
Seres Humanos
Doenças Inflamatórias Intestinais/tratamento farmacológico
Lipopolissacarídeos
Masculino
Camundongos
Raízes de Plantas/química
Ratos
Ratos Sprague-Dawley
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (Pyrans); 0 (Tumor Necrosis Factor-alpha); 27415-26-5 (8-epi-prostaglandin F2alpha); 8KGS1DC5ZU (harpagoside); B7IN85G1HY (Dinoprost); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5821


  3 / 103 MEDLINE  
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[PMID]:28106392
[Au] Autor:Chung HJ; Kim WK; Oh J; Kim MR; Shin JS; Lee J; Ha IH; Lee SK
[Ad] Endereço:College of Pharmacy, Natural Products Research Institute, Seoul National University , Seoul 151-742, Korea.
[Ti] Título:Anti-Osteoporotic Activity of Harpagoside by Upregulation of the BMP2 and Wnt Signaling Pathways in Osteoblasts and Suppression of Differentiation in Osteoclasts.
[So] Source:J Nat Prod;80(2):434-442, 2017 Feb 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Harpagoside (1) is an iridoid glycoside isolated from the radix of Harpagophytum procumbens var. sublobatum, commonly called Devil's claw. The anti-osteoporotic effect of 1 was investigated in both in vitro cell cultures and in vivo using an ovariectomized (OVX) mouse model. Compound 1 induced bone formation by stimulating osteoblast proliferation, alkaline phosphatase activity, and mineralization in osteoblastic MC3T3-E1 cells. Treatment with 1 increased the mRNA and protein expression of bone formation biomarkers through regulation of the BMP2 and Wnt signaling pathway in MC3T3-E1 cells. Compound 1 also suppressed the RANKL-induced osteoclastogenesis of cultured mouse bone marrow cells. Oral administration of 1 restored the OVX-induced destruction of trabecular bone. The bone mineral density of the femur was also increased significantly by 1. The elevated serum levels of osteocalcin, C-terminal telopeptide, and tartrate-resistant acid phosphatase in the OVX mice were decreased by treatment with 1. These findings suggest that compound 1 may protect against bone loss induced by OVX in mice by regulating stimulation of osteoblast differentiation and inhibition of osteoclast resorption. Therefore, harpagoside (1) is a potential candidate for management of postmenopausal osteoporosis.
[Mh] Termos MeSH primário: Glicosídeos/farmacologia
Harpagophytum/química
Osteoblastos/efeitos dos fármacos
Osteoclastos/efeitos dos fármacos
Osteoporose Pós-Menopausa/tratamento farmacológico
Piranos/farmacologia
Via de Sinalização Wnt/fisiologia
[Mh] Termos MeSH secundário: Animais
Densidade Óssea/efeitos dos fármacos
Proteína Morfogenética Óssea 2/metabolismo
Reabsorção Óssea/metabolismo
Diferenciação Celular/efeitos dos fármacos
Feminino
Fêmur/efeitos dos fármacos
Glicosídeos/química
Seres Humanos
Camundongos
Estrutura Molecular
Osteoblastos/metabolismo
Osteocalcina/análise
Osteocalcina/sangue
Osteoclastos/metabolismo
Osteogênese/efeitos dos fármacos
Piranos/química
Ligante RANK/metabolismo
Ligante RANK/farmacologia
República da Coreia
Ativação Transcricional
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BMP2 protein, human); 0 (Bone Morphogenetic Protein 2); 0 (Glycosides); 0 (Pyrans); 0 (RANK Ligand); 0 (TNFSF11 protein, human); 104982-03-8 (Osteocalcin); 8KGS1DC5ZU (harpagoside)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00964


  4 / 103 MEDLINE  
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Ribeiro, Lúcia Regina
Mantovani, Mário Sérgio
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[PMID]:27991703
[Au] Autor:Biazi BI; D'Epiro GF; Zanetti TA; de Oliveira MT; Ribeiro LR; Mantovani MS
[Ad] Endereço:Departamento de Biologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina-UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil.
[Ti] Título:Risk Assessment via Metabolism and Cell Growth Inhibition in a HepG2/C3A Cell Line Upon Treatment with Arpadol and its Active Component Harpagoside.
[So] Source:Phytother Res;31(3):387-394, 2017 Mar.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Harpagophytum procumbens (Hp) has been used as antiinflammatory and analgesic agent for the treatment of rheumatic diseases. The principal active component of Hp is harpagoside (HA). We tested the toxicity of this new therapeutic agent in a hepatic cell line (HepG2/C3A). Hp was found to be cytotoxic, and HA was found to decrease the number of cells in S phase, increase the number of cells in G2/M phase and induce apoptosis. Neither Hp nor HA was genotoxic. The expression of CDK6 and CTP3A4 was reduced by Hp, and both HA and Hp caused a significant reduction of CYP1A2 and CYP3A4 expression. It is possible that the cytotoxicity caused by HA and Hp does not involve transcriptional regulation of the cyclins and CDKs tested but is instead related to the inhibition of metabolism. This is evidenced by the results of an MTT assay and changes in the expression of genes related to drug metabolism, leading to cell death. Indeed, the cells exhibited decreased proliferation upon exposure to Hp and HA. The data show that treatment with either Hp or HA can be cytotoxic, and this should be taken into consideration when balancing the risks and benefits of treatments for rheumatic diseases. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Glicosídeos/toxicidade
Inibidores do Crescimento/toxicidade
Hepatócitos/efeitos dos fármacos
Hepatócitos/metabolismo
Extratos Vegetais/toxicidade
Piranos/toxicidade
[Mh] Termos MeSH secundário: Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Glicosídeos/farmacologia
Inibidores do Crescimento/farmacologia
Harpagophytum/química
Células Hep G2
Seres Humanos
Extratos Vegetais/farmacologia
Piranos/farmacologia
Medição de Risco
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Growth Inhibitors); 0 (Plant Extracts); 0 (Pyrans); 0 (arpadol); 8KGS1DC5ZU (harpagoside)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5757


  5 / 103 MEDLINE  
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[PMID]:27082319
[Au] Autor:Haseeb A; Ansari MY; Haqqi TM
[Ad] Endereço:Department of Anatomy and Neurobiology, North East Ohio Medical University, 4209 State Route 44, Rootstown, Ohio, 44272.
[Ti] Título:Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.
[So] Source:J Orthop Res;35(2):311-320, 2017 Feb.
[Is] ISSN:1554-527X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is growing evidence in support of the involvement of inflammatory response in the pathogenesis of osteoarthritis (OA). Harpagoside, one of the bioactive components of Harpagophytum procumbens (Hp), has been shown to possess anti-inflammatory properties. Here we used an in vitro model of inflammation in OA to investigate the potential of harpagoside to suppress the production of inflammatory cytokines/chemokines such as IL-6 and matrix degrading proteases. We further investigated the likely targets of harpagoside in primary human OA chondrocytes. OA chondrocytes were pre-treated with harpagoside before stimulation with IL-1ß. mRNA expression profile of 92 cytokines/chemokines was determined using TaqMan Human Chemokine PCR Array. Expression levels of selected mRNAs were confirmed using TaqMan assays. Protein levels of IL-6 and MMP-13 were assayed by ELISA and immunoblotting. Total protein levels and phosphorylation of signaling proteins were determined by immunoblotting. Cellular localization of IL-6 and c-Fos was performed by immunofluorescence and confocal microscopy. DNA binding activity of c-FOS/AP-1 was determined by ELISA. Harpagoside significantly altered the global chemokine expression profile in IL-1ß-stimulated OA chondrocytes. Expression of IL-6 was highly induced by IL-1ß, which was significantly inhibited by pre-treatment of OA chondrocytes with harpagoside. Harpagoside did not inhibit the IL-1ß-induced activation of NF-κB and C/EBPß transcription factors but suppressed the IL-1ß-triggered induction, phosphorylation, and DNA binding activity of c-FOS, one of the main components of AP-1 transcription factors. Further, harpagoside significantly inhibited the expression of MMP-13 in OA chondrocytes under pathological conditions. siRNA-mediated knockdown of IL-6 resulted in suppressed expression and secretion of MMP-13 directly linking the role of IL-6 with MMP-13 expression. Taken together, the present study suggests that harpagoside exerts a significant anti-inflammatory effect by inhibiting the inflammatory stimuli mediated by suppressing c-FOS/AP-1 activity in OA chondrocytes under pathological conditions. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:311-320, 2017.
[Mh] Termos MeSH primário: Condrócitos/efeitos dos fármacos
Glicosídeos/uso terapêutico
Interleucina-6/metabolismo
Osteoartrite/tratamento farmacológico
Piranos/uso terapêutico
[Mh] Termos MeSH secundário: Proteína beta Intensificadora de Ligação a CCAAT/metabolismo
Quimiocinas/metabolismo
Condrócitos/metabolismo
Avaliação Pré-Clínica de Medicamentos
Glicosídeos/farmacologia
Harpagophytum
Seres Humanos
Interleucina-1beta
Interleucina-6/antagonistas & inibidores
Metaloproteinase 13 da Matriz/metabolismo
NF-kappa B/metabolismo
Osteoartrite/metabolismo
Fitoterapia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Cultura Primária de Células
Proteínas Proto-Oncogênicas c-fos/metabolismo
Piranos/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Fator de Transcrição AP-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCAAT-Enhancer-Binding Protein-beta); 0 (Chemokines); 0 (Glycosides); 0 (IL6 protein, human); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Proto-Oncogene Proteins c-fos); 0 (Pyrans); 0 (Reactive Oxygen Species); 0 (Transcription Factor AP-1); 8KGS1DC5ZU (harpagoside); EC 3.4.24.- (MMP13 protein, human); EC 3.4.24.- (Matrix Metalloproteinase 13)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE
[do] DOI:10.1002/jor.23262


  6 / 103 MEDLINE  
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[PMID]:27429708
[Au] Autor:Muzila M; Rumpunen K; Wright H; Roberts H; Grant M; Nybom H; Sehic J; Ekholm A; Widén C
[Ad] Endereço:Department of Plant Breeding, Swedish University of Agricultural Sciences, Balsgård, Fjälkestadsvägen 459, 291 94 Kristianstad, Sweden; Biological Sciences, University of Botswana, Private Bag UB 00704, Gaborone, Botswana.
[Ti] Título:Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil's Claw (Harpagophytum).
[So] Source:Oxid Med Cell Longev;2016:3841803, 2016.
[Is] ISSN:1942-0994
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Harpagophytum, Devil's Claw, is a genus of tuberiferous xerophytic plants native to southern Africa. Some of the taxa are appreciated for their medicinal effects and have been traditionally used to relieve symptoms of inflammation. The objectives of this pilot study were to investigate the antioxidant capacity and the content of total phenols, verbascoside, isoverbascoside, and selected iridoids, as well as to investigate the capacity of various Harpagophytum taxa in suppressing respiratory burst in terms of reactive oxygen species produced by human neutrophils challenged with phorbol myristate acetate (PMA), opsonised Staphylococcus aureus, and Fusobacterium nucleatum. Harpagophytum plants were classified into different taxa according to morphology, and DNA analysis was used to confirm the classification. A putative new variety of H. procumbens showed the highest degree of antioxidative capacity. Using PMA, three Harpagophytum taxa showed anti-inflammatory effects with regard to the PBS control. A putative hybrid between H. procumbens and H. zeyheri in contrast showed proinflammatory effect on the response of neutrophils to F. nucleatum in comparison with treatment with vehicle control. Harpagophytum taxa were biochemically very variable and the response in suppressing respiratory burst differed. Further studies with larger number of subjects are needed to corroborate anti-inflammatory effects of different taxa of Harpagophytum.
[Mh] Termos MeSH primário: Harpagophytum/química
Neutrófilos/metabolismo
Extratos Vegetais/farmacologia
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Adulto
Antioxidantes/análise
Ácido Ascórbico/farmacologia
Biodiversidade
Botsuana
Sobrevivência Celular/efeitos dos fármacos
Feminino
Geografia
Glucosídeos/farmacologia
Seres Humanos
Iridoides/farmacologia
Ferro/metabolismo
Luminol/metabolismo
Meia-Idade
Neutrófilos/efeitos dos fármacos
Fenóis/análise
Plasma/metabolismo
Análise de Componente Principal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Glucosides); 0 (Iridoids); 0 (Phenols); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 588LJK42AP (isoacteoside); 5EXP385Q4F (Luminol); E1UOL152H7 (Iron); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE
[do] DOI:10.1155/2016/3841803


  7 / 103 MEDLINE  
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[PMID]:27209428
[Au] Autor:Moura Mdel G; Lopes LC; Biavatti MW; Busse JW; Wang L; Kennedy SA; Bhatnaga N; Bergamaschi Cde C
[Ad] Endereço:Department of Pharmaceutical Sciences, University of Sorocaba, Sorocaba, São Paulo, Brazil.
[Ti] Título:Brazilian oral herbal medication for osteoarthritis: a systematic review protocol.
[So] Source:Syst Rev;5:86, 2016 May 21.
[Is] ISSN:2046-4053
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Osteoarthritis affects 1 % of the world's population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are commonly used in Brazil to manage symptoms associated with osteoarthritis, and some of them are financed by the Brazilian government; however, the effectiveness of most of these agents is uncertain. The aim was to systematically review the efficacy and safety of 13 oral herbal medications used in Brazil for the treatment of osteoarthritis. METHODS: Randomized clinical trials eligible for our systematic review will enroll adults with osteoarthritis treated by a Brazilian herbal medication or a control group (placebo or active control). Using terms to include all forms of osteoarthritis combined with herbal medications, we will search the following electronic databases: Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; CINAHL; Web of Science; Health Star; AMED, the database of the Cochrane Complementary Medicine Field, LILACS; CAB abstracts, Clinical trial.gov, WHO trials registry, and Bank of Brazil Thesis (CAPES), to 31 January 2016, without restrictions concerning language or status of publication. Outcomes of interest include the following: symptom relief (e.g., pain), adverse events (gastrointestinal bleeding, epigastric pain, nausea, and allergic reactions), discontinuation due to adverse events, quality of life, and the satisfaction with the treatment. Dichotomous data will be summarized as risk ratios; continuous data will be given as standard average differences with 95 % confidence intervals. A team of reviewers will assess each citation independently for eligibility and in duplicate it. For eligible studies, the same reviewers will perform data extraction, bias risk assessment, and determination of the overall quality of evidence for each of the outcomes using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) classification system. DISCUSSION: This is the first study that will evaluate the use of herbal medications used in Brazil for the treatment of pain caused by osteoarthritis. The results could guide prescribers in decision-making in clinical practice, to inform the patients with pain caused by osteoarthritis in relation to effective and safe treatment options and to inform the managers of the public health system which of the plants could actually be financed by the Brazilian government. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 42015019793.
[Mh] Termos MeSH primário: Osteoartrite/tratamento farmacológico
Fitoterapia
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Boswellia
Brasil
Unha-de-Gato
Chenopodium ambrosioides
Cordia
Curcuma
Fabaceae
Harpagophytum
Seres Humanos
Persea
Salix
Resultado do Tratamento
Uncaria
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160523
[St] Status:MEDLINE
[do] DOI:10.1186/s13643-016-0261-1


  8 / 103 MEDLINE  
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[PMID]:26979254
[Au] Autor:Schopohl P; Grüneberg P; Melzig MF
[Ad] Endereço:Freie Universität Berlin, Fachbereich für Pharmazie, Königin-Luise-Straße 2+4, 14195 Berlin, Germany. Electronic address: pschopohl@uni-potsdam.de.
[Ti] Título:The influence of harpagoside and harpagide on TNFα-secretion and cell adhesion molecule mRNA-expression in IFNγ/LPS-stimulated THP-1 cells.
[So] Source:Fitoterapia;110:157-65, 2016 Apr.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Inflammation does not only lead to pain and functio laesa in the affected tissue but is also implicated in the onset and progression of cardiovascular diseases and cancer. Many medicinal plants show anti-inflammatory properties yet plant-constituents and their effect on molecular pathways involved in the attenuation of inflammation as well as cell migration are only poorly understood. Harpagophytum procumbens DC. ex MEISN. is a potent plant used as an immune modulator in traditional herbal medicine. Aim of this study was to investigate the influence of harpagoside and harpagide on TNFα-secretion in undifferentiated and differentiated THP-1 cells under inflammatory conditions as well as their implication in cellular migration into inflamed tissue. We found that both iridoids decrease TNFα-secretion in PMA-differentiated THP-1 cells whereas undifferentiated cells were poorly affected. Yet, in undifferentiated cells harpagoside and harpagide induced mRNA-expression of certain proteins involved in leukocyte transmigration. Especially TNFα and ICAM-1 mRNA-expression was positively affected after 3h and expression could be maintained on high levels even after 48h. L-selectin and PSGL-1 were strongly induced after 48h of stimulation. This ambiguous effect of harpagoside and harpagide highlights their immune modulatory function by facilitating cell migration into the inflamed tissue, whereby in consequence the anti-inflammatory activity of the resident macrophages was also found to be promoted.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Glicosídeos/química
Glicosídeos Iridoides/química
Monócitos/efeitos dos fármacos
Piranos/química
Fator de Necrose Tumoral alfa/metabolismo
[Mh] Termos MeSH secundário: Diferenciação Celular
Linhagem Celular
Movimento Celular
Harpagophytum/química
Seres Humanos
Molécula 1 de Adesão Intercelular/metabolismo
Interferon gama
Selectina L/metabolismo
Lipopolissacarídeos
Macrófagos/efeitos dos fármacos
Glicoproteínas de Membrana/metabolismo
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Glycosides); 0 (Iridoid Glycosides); 0 (Lipopolysaccharides); 0 (Membrane Glycoproteins); 0 (P-selectin ligand protein); 0 (Pyrans); 0 (TNF protein, human); 0 (Tumor Necrosis Factor-alpha); 126547-89-5 (Intercellular Adhesion Molecule-1); 126880-86-2 (L-Selectin); 82115-62-6 (Interferon-gamma); 8KGS1DC5ZU (harpagoside); OF59XHX7SR (harpagide)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE


  9 / 103 MEDLINE  
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[PMID]:26732278
[Au] Autor:Schaffer LF; de Freitas CM; Chiapinotto Ceretta AP; Peroza LR; de Moraes Reis E; Krum BN; Busanello A; Boligon AA; Sudati JH; Fachinetto R; Wagner C
[Ad] Endereço:Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
[Ti] Título:Harpagophytum Procumbens Ethyl Acetate Fraction Reduces Fluphenazine-Induced Vacuous Chewing Movements and Oxidative Stress in Rat Brain.
[So] Source:Neurochem Res;41(5):1170-84, 2016 May.
[Is] ISSN:1573-6903
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Long-term treatment with fluphenazine is associated with manifestation of extrapyramidal side effects, such as tardive dyskinesia. The molecular mechanisms related to the pathophysiology of TD remain unclear, and several hypotheses, including a role for oxidative stress, have been proposed. Harpagophytum procumbens is an herbal medicine used mainly due to anti-inflammatory effects, but it also exhibits antioxidant effects. We investigated the effect of ethyl acetate fraction of H. procumbens (EAF HP) in fluphenazine-induced orofacial dyskinesia by evaluating behavioral parameters at different times (vacuous chewing movements (VCM's) and locomotor and exploratory activity), biochemical serological analyses, and biochemical markers of oxidative stress of the liver, kidney, cortex, and striatum. Chronic administration of fluphenazine (25 mg/kg, intramuscular (i.m) significantly increased the VCMs at all analyzed times (2, 7, 14, and 21 days), and this was inhibited by EAF HP (especially at a dose of 30 mg/kg). Fluphenazine decreased locomotion and exploratory activity, and EAF HP did not improve this decrease. Fluphenazine induced oxidative damage, as identified by changes in catalase activity and ROS levels in the cortex and striatum, which was reduced by EAF HP, especially in the striatum. In the cortex, EAF HP was protective against fluphenazine-induced changes in catalase activity but not against the increase in ROS level. Furthermore, EAF HP was shown to be safe, since affected serum biochemical parameters or parameters of oxidative stress in the liver and kidney. These findings suggest that the H. procumbens is a promising therapeutic agent for the treatment of involuntary oral movements.
[Mh] Termos MeSH primário: Acetatos/química
Antioxidantes/farmacologia
Antipsicóticos/toxicidade
Encéfalo/efeitos dos fármacos
Flufenazina/toxicidade
Harpagophytum/química
Mastigação/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Discinesia Tardia/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/uso terapêutico
Encéfalo/metabolismo
Comportamento Exploratório/efeitos dos fármacos
Depuradores de Radicais Livres/farmacologia
Depuradores de Radicais Livres/uso terapêutico
Masculino
Atividade Motora/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Ratos Wistar
Solventes
Discinesia Tardia/induzido quimicamente
Discinesia Tardia/metabolismo
Discinesia Tardia/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetates); 0 (Antioxidants); 0 (Antipsychotic Agents); 0 (Free Radical Scavengers); 0 (Plant Extracts); 0 (Solvents); 76845O8NMZ (ethyl acetate); S79426A41Z (Fluphenazine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160107
[St] Status:MEDLINE
[do] DOI:10.1007/s11064-015-1811-y


  10 / 103 MEDLINE  
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[PMID]:26614913
[Au] Autor:Haas C; Hegner R; Helbig K; Bartels K; Bley T; Weber J
[Ad] Endereço:Institute of Food Technology and Bioprocess Engineering, Technische Universität Dresden, Bergstraße 120, Dresden, 01062, Germany.
[Ti] Título:Two parametric cell cycle analyses of plant cell suspension cultures with fragile, isolated nuclei to investigate heterogeneity in growth of batch cultivations.
[So] Source:Biotechnol Bioeng;113(6):1244-50, 2016 Jun.
[Is] ISSN:1097-0290
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plant cell suspensions are frequently considered to be heterogeneous with respect to growth in terms of progression of the cells through the cell cycle and biomass accumulation. Thus, segregated data of fractions in different cycle phases during cultivation is needed to develop robust production processes. Bromodeoxyuridine (BrdU) incorporation and BrdU-antibodies or 5-ethynyl-2'-deoxyuridine (EdU) click-it chemistry are frequently used to acquire such information. However, their use requires centrifugation steps that cannot be readily applied to sensitive cells, particularly if nuclei have to be extracted from the protective cellular milieu and envelopes for DNA analysis. Therefore, we have established a BrdU-Hoechst stain quenching protocol for analyzing nuclei directly isolated from delicate plant cell suspension cultures. After adding BrdU to test Harpagophytum procumbens cell suspension cultures the cell cycle distribution could be adequately resolved using its incorporation for the following 72 h (after which BrdU slowed biomass accumulation). Despite this limitation, the protocol allows resolution of the cell cycle distribution of cultures that cannot be analyzed using commonly applied methods due to the cells' fragility. The presented protocol enabled analysis of cycling heterogeneities in H. procumbens batch cultivations, and thus should facilitate process control of secondary metabolite production from fragile plant in vitro cultures. Biotechnol. Bioeng. 2016;113: 1244-1250. © 2015 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Técnicas de Cultura Celular por Lotes/métodos
Núcleo Celular/fisiologia
Proliferação Celular/fisiologia
Citometria de Fluxo/métodos
Harpagophytum/citologia
Harpagophytum/fisiologia
[Mh] Termos MeSH secundário: Ciclo Celular/fisiologia
Núcleo Celular/ultraestrutura
Separação Celular/métodos
Células Cultivadas
Microscopia de Fluorescência/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151129
[St] Status:MEDLINE
[do] DOI:10.1002/bit.25894



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