Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.690.750 [Categoria DeCS]
Referências encontradas : 393 [refinar]
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  1 / 393 MEDLINE  
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[PMID]:28743426
[Au] Autor:Li PH; Gunawardana N; Thomas I; Ue KL; Siew L; Watts TJ; Bintcliffe K; Haque R; Rutkowski K; Skypala I; Till SJ
[Ad] Endereço:Department of Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
[Ti] Título:Sesame allergy in adults: Investigation and outcomes of oral food challenges.
[So] Source:Ann Allergy Asthma Immunol;119(3):285-287, 2017 Sep.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/administração & dosagem
Hipersensibilidade Alimentar/diagnóstico
Imunoglobulina E/sangue
Proteínas de Plantas/administração & dosagem
Sesamum/imunologia
[Mh] Termos MeSH secundário: Administração Oral
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Hipersensibilidade Alimentar/sangue
Hipersensibilidade Alimentar/etiologia
Hipersensibilidade Alimentar/imunologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Sesamum/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Plant Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  2 / 393 MEDLINE  
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[PMID]:28812427
[Au] Autor:Furumoto T; Sato R
[Ad] Endereço:a Faculty of Agriculture, Department of Applied Biological Science , Kagawa University , Kagawa , Japan.
[Ti] Título:Biosynthesis of anthraquinone derivatives in a Sesamum indicum hairy root culture.
[So] Source:Biosci Biotechnol Biochem;81(10):1868-1873, 2017 Oct.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In order to investigate the intermediacy of 2-(4-methylpent-3-en-1-yl)anthraquinone (MPAQ), a possible intermediate for the biosynthesis of anthraquinone derivatives in sesame (Sesamum indicum), H-labeled MPAQ was administered to a hairy root culture of S. indicum. Efficient conversion of fed MPAQ to 2-[(Z)-4-methylpenta-1,3-dien-1-yl]anthraquinone ((Z)-MPDEAQ) was observed. Furthermore, administration experiment with H-labeled 2-geranyl-1,4-naphthohydroquinone, another possible intermediate, showed that it was converted to MPAQ and (Z)-MPDEAQ. The results clearly demonstrated that these substrates are the actual precursors for the production of (Z)-MPDEAQ. In contrast, neither MPAQ nor 2-geranyl-1,4-naphthohydroquinone was converted to anthrasesamone B and 2,3-epoxyanthrasesamone B, other anthraquinone derivatives in the hairy roots, suggesting that these substrates may not be the common precursors in the biosynthesis of anthraquinone derivatives.
[Mh] Termos MeSH primário: Antraquinonas/metabolismo
Raízes de Plantas/crescimento & desenvolvimento
Sesamum/crescimento & desenvolvimento
Sesamum/metabolismo
[Mh] Termos MeSH secundário: Técnicas de Cultura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 030MS0JBDO (9,10-anthraquinone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1362974


  3 / 393 MEDLINE  
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[PMID]:28763962
[Au] Autor:Bodoira R; Velez A; Andreatta AE; Martínez M; Maestri D
[Ad] Endereço:Instituto Multidisciplinario de Biología Vegetal (IMBIV), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Córdoba (UNC), Instituto de Ciencia y Tecnología de los Alimentos (ICTA - FCEFyN - UNC), Av. Vélez Sarsfield 1611, Córdoba, Argentina.
[Ti] Título:Extraction of bioactive compounds from sesame (Sesamum indicum L.) defatted seeds using water and ethanol under sub-critical conditions.
[So] Source:Food Chem;237:114-120, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sesame seeds contain a vast array of lignans and phenolic compounds having important biological properties. An optimized method to obtain these seed components was designed by using water and ethanol at high pressure and temperature conditions. The maximum concentrations of lignans, total phenolics, flavonoids and flavonols compounds were achieved at 220°C extraction temperature and 8MPa pressure, using 63.5% ethanol as co-solvent. Under these conditions, the obtained sesame extracts gave the best radical scavenging capacity. Kinetic studies showed a high extraction rate of phenolic compounds until the first 50min of extraction, and it was in parallel with the highest scavenging capacity. The comparison of our results with those obtained under conventional extraction conditions (normal pressure, ambient temperature) suggests that recovery of sesame bioactive compounds may be markedly enhanced using water/ethanol mixtures at sub-critical conditions.
[Mh] Termos MeSH primário: Sesamum
[Mh] Termos MeSH secundário: Antioxidantes
Etanol
Cinética
Sementes
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 059QF0KO0R (Water); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  4 / 393 MEDLINE  
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[PMID]:28603986
[Au] Autor:Zha M; Yin S; Sun B; Wang X; Wang C
[Ad] Endereço:Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University , Beijing 100048, China.
[Ti] Título:STR3 and CYS3 Contribute to 2-Furfurylthiol Biosynthesis in Chinese Sesame-Flavored Baijiu Yeast.
[So] Source:J Agric Food Chem;65(27):5503-5511, 2017 Jul 12.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:2-Furfurylthiol is an important aroma compound with characteristic sesame flavor. It was recently identified as the representative aroma compound of Chinese sesame-flavored Baijiu. But its formation mechanism is unclear. In this study, the dominant yeast species Saccharomyces cerevisiae, Pichia kudriavzevii, and Wickerhamomyces anomalus were isolated from samples of Chinese sesame-flavored fermentation and were screened for the capacity of 2-furfurylthiol biosynthesis. Some isolates were found to be capable of generating 2-furfurylthiol using furfural and l-cysteine as precursors, among which S. cerevisiae G20 exhibited the strongest capacity with a yield of 3.03 mg/L. Furthermore, the genes STR3 and CYS3 from S. cerevisiae were cloned and overexpressed in the reference strain S. cerevisiae S288c and the isolate strain G20, respectively, which resulted in a significant increase in 2-furfurylthiol release in the two strains. Moreover, inactivation of STR3 gene in S288c and G20 led to obvious reduction in 2-furfurylthiol production, demonstrating that STR3 got involved in 2-furfurylthiol biosynthesis in S. cerevisiae. It is the first time that the yeast isolates with high capacity of 2-furfurylthiol biosynthesis were found during Chinese sesame-flavored Baijiu fermentation and confirmed that the genes STR3 and CYS3 were closely relevant to 2-furfurylthiol biosynthesis.
[Mh] Termos MeSH primário: Aromatizantes/metabolismo
Furanos/metabolismo
Sesamum/química
Compostos de Sulfidrila/metabolismo
Leveduras/metabolismo
[Mh] Termos MeSH secundário: China
Fermentação
Aromatizantes/química
Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Leveduras/química
Leveduras/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavoring Agents); 0 (Fungal Proteins); 0 (Furans); 0 (Sulfhydryl Compounds); 29W096TCPG (furfuryl mercaptan)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01359


  5 / 393 MEDLINE  
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[PMID]:28514997
[Au] Autor:Peters RL; Koplin JJ; Gurrin LC; Dharmage SC; Wake M; Ponsonby AL; Tang MLK; Lowe AJ; Matheson M; Dwyer T; Allen KJ; HealthNuts Study
[Ad] Endereço:Murdoch Childrens Research Institute, Parkville, Australia.
[Ti] Título:The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up.
[So] Source:J Allergy Clin Immunol;140(1):145-153.e8, 2017 Jul.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse. OBJECTIVE: This study aimed to report the updated prevalence of food allergy at age 1 year from the whole cohort, and to report the prevalence of food allergy, asthma, eczema, and allergic rhinitis at age 4 years. METHODS: HealthNuts is a population-based cohort study with baseline recruitment of 5276 one-year-old children who underwent skin prick test (SPT) to 4 food allergens and those with detectable SPT results had formal food challenges. At age 4 years, parents completed a questionnaire (81.3% completed) and those who previously attended the HealthNuts clinic at age 1 year or reported symptoms of a new food allergy were invited for an assessment that included SPT and oral food challenges. Data on asthma, eczema, and allergic rhinitis were captured by validated International Study of Asthma and Allergies in Childhood questionnaires. RESULTS: The prevalence of challenge-confirmed food allergy at age 1 and 4 years was 11.0% and 3.8%, respectively. At age 4 years, peanut allergy prevalence was 1.9% (95% CI, 1.6% to 2.3%), egg allergy was 1.2% (95% CI, 0.9% to 1.6%), and sesame allergy was 0.4% (95% CI, 0.3% to 0.6%). Late-onset peanut allergy at age 4 years was rare (0.2%). The prevalence of current asthma was 10.8% (95% CI, 9.7% to 12.1%), current eczema was 16.0% (95% CI, 14.7% to 17.4%), and current allergic rhinitis was 8.3% (95% CI, 7.2% to 9.4%). Forty percent to 50% of this population-based cohort experienced symptoms of an allergic disease in the first 4 years of their life. CONCLUSIONS: Although the prevalence of food allergy decreased between age 1 year and age 4 years in this population-based cohort, the prevalence of any allergic disease among 4-year-old children in Melbourne, Australia, is remarkably high.
[Mh] Termos MeSH primário: Asma/epidemiologia
Eczema/epidemiologia
Hipersensibilidade Alimentar/epidemiologia
Rinite Alérgica/epidemiologia
[Mh] Termos MeSH secundário: Alérgenos/imunologia
Animais
Arachis/efeitos adversos
Austrália/epidemiologia
Pré-Escolar
Feminino
Seguimentos
Hipersensibilidade Alimentar/diagnóstico
Seres Humanos
Lactente
Masculino
Leite/efeitos adversos
Óvulo/imunologia
Prevalência
Alimentos Marinhos/efeitos adversos
Sesamum/efeitos adversos
Testes Cutâneos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE


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[PMID]:28494410
[Au] Autor:Feng Y; Liu Y; Xue L; Sun H; Guo Z; Zhang Y; Yang L
[Ad] Endereço:Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Agro-Environment in Downstream of Yangtze Plain, Ministry of Agriculture, Nanjing 210014, China; State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chine
[Ti] Título:Carboxylic acid functionalized sesame straw: A sustainable cost-effective bioadsorbent with superior dye adsorption capacity.
[So] Source:Bioresour Technol;238:675-683, 2017 Aug.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study prepared a carboxylic functionalized bioadsorbent that met the "4-E" criteria: Efficient, Economical, Environmentally friendly, and Easily-produced. Sesame straw (Sesamum indicum L.) was functionalized through treatment with citric acid (SSCA) and tartaric acid (SSTA). The products were examined for adsorption capacity and mechanisms. Langmuir model gave the best fit for the isotherm data, and the maximum monolayer adsorption capacity of SSCA was 650mgg for methylene blue (MB). The excellent dye adsorption capacity of SSCA can be attributed to the introduction of ester groups during citric-acid modification and the tube-like structures (i.e., sesame straw cell wall remnants). At last, the cost of carboxylic acid functionalized bioadsorbents was evaluated, which showed that SSCA would be the most cost-effective bioadsorbent. Additionally, this study presents a thermo-decomposition methodology for contaminant-loaded bioadsorbent. Results showed that SSCA is probably one of the few bioadsorbents that can be produced and applied in industrial scale.
[Mh] Termos MeSH primário: Sesamum
Poluentes Químicos da Água
[Mh] Termos MeSH secundário: Adsorção
Azul de Metileno
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


  7 / 393 MEDLINE  
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[PMID]:28436656
[Au] Autor:Zhang H; Yang M; Luan Q; Tang H; Huang F; Xiang X; Yang C; Bao Y
[Ad] Endereço:Department of Product Processing and Nutriology, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Ministry of Agriculture Key Laboratory of Oil Crops Biology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences , Wuhan 430062, China.
[Ti] Título:Cellulose Anionic Hydrogels Based on Cellulose Nanofibers As Natural Stimulants for Seed Germination and Seedling Growth.
[So] Source:J Agric Food Chem;65(19):3785-3791, 2017 May 17.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cellulose anionic hydrogels were successfully prepared by dissolving TEMPO-oxidized cellulose nanofibers in NaOH/urea aqueous solution and being cross-linked with epichlorohydrin. The hydrogels exhibited microporous structure and high hydrophilicity, which contribute to the excellent water absorption property. The growth indexes, including the germination rate, root length, shoot length, fresh weight, and dry weight of the seedlings, were investigated. The results showed that cellulose anionic hydrogels with suitable carboxylate contents as plant growth regulators could be beneficial for seed germination and growth. Moreover, they presented preferable antifungal activity during the breeding and growth of the sesame seed breeding. Thus, the cellulose anionic hydrogels with suitable carboxylate contents could be applied as soilless culture mediums for plant growth. This research provided a simple and effective method for the fabrication of cellulose anionic hydrogel and evaluated its application in agriculture.
[Mh] Termos MeSH primário: Agricultura/instrumentação
Celulose/química
Hidrogéis/química
Plântulas/crescimento & desenvolvimento
Sementes/crescimento & desenvolvimento
Sesamum/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Agricultura/métodos
Germinação
Plântulas/metabolismo
Sementes/metabolismo
Sesamum/metabolismo
Água/química
Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrogels); 059QF0KO0R (Water); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b05815


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[PMID]:28340563
[Au] Autor:Yu J; Wang L; Guo H; Liao B; King G; Zhang X
[Ad] Endereço:The Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Oil Crops Research Institute, the Chinese Academy of Agricultural Sciences, Wuhan, 430062, China.
[Ti] Título:Genome evolutionary dynamics followed by diversifying selection explains the complexity of the Sesamum indicum genome.
[So] Source:BMC Genomics;18(1):257, 2017 03 24.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Whole genome duplication (WGD) and tandem duplication (TD) provide two critical sources of raw genetic material for genome complexity and evolutionary novelty. Little is known about the complexity of the Sesamum indicum genome after it diverged from a common ancestor with the paleodiploid Vitis vinifera and further experienced WGD and TD events. RESULTS: Here, we analyzed the functional divergence of different classes of inter- and intra-genome gene pairs from ancestral events to uncover multiple-layers of evolutionary dynamics acting during the process of forming the modern S. indicum genome. Comprehensive inter-genome analyses revealed that 60% and 70% of syntenic orthologous gene pairs were retained among the two subgenomes in S. indicum compared to V. vinifera, although there was no evidence of significant differences under selection pressure. For the intra-genomic analyses, 5,932 duplicated gene pairs experienced fractionation, with the remaining 1,236 duplicated gene pairs having undergone functional divergence under diversifying selection. Analysis of the TD events indicated that 2,945 paralogous gene pairs, from 1,089 tandem arrays of 2-16 genes, experienced functional divergence under diversifying selection. Sequence diversification of different classes of gene pairs revealed that most of TD events occurred after the WGD event, with others following the ancestral gene order indicating ancient TD events at some time prior to the WGD event. Our comparison-of-function analyses for different classes of gene pairs indicated that the WGD and TD evolutionary events were both responsible for introducing genes that enabled exploration of novel and complementary functionalities, whilst maintaining individual plant ruggedness. CONCLUSIONS: In this study, we first investigated functional divergence of different classes of gene pairs to characterize the dynamic processes associated with each evolutionary event in S. indicum. The data demonstrated massive and distinct functional divergence among different classes of gene pairs, and provided a genome-scale view of gene function diversification explaining the complexity of the S. indicum genome. We hope this provides a biological model to study the mechanism of plant species formation, particularly in the context of the evolutionary history of flowering plants, and offers novel insights for the study of angiosperm genomes.
[Mh] Termos MeSH primário: Evolução Molecular
Genoma de Planta
Genômica
Seleção Genética
Sesamum/genética
[Mh] Termos MeSH secundário: Mapeamento Cromossômico
Duplicação Gênica
Heterogeneidade Genética
Variação Genética
Genômica/métodos
Família Multigênica
Sintenia
Sequências de Repetição em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-017-3599-4


  9 / 393 MEDLINE  
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[PMID]:28332903
[Au] Autor:Aslam F; Iqbal S; Nasir M; Anjum AA; Swan P; Sweazea K
[Ad] Endereço:1 Department of Food Science and Human Nutrition, Faculty of Biosciences, University of Veterinary and Animal Sciences Lahore , Lahore, Pakistan .
[Ti] Título:Evaluation of White Sesame Seed Oil on Glucose Control and Biomarkers of Hepatic, Cardiac, and Renal Functions in Male Sprague-Dawley Rats with Chemically Induced Diabetes.
[So] Source:J Med Food;20(5):448-457, 2017 May.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:White sesame seed oil (WSSO) has been used in cooking and food preparations for centuries. It has many purported health benefits and may be a promising nutraceutical. The primary purpose of this study was to examine the effects of WSSO on fasting blood glucose (GLU) and insulin (INS) in male Sprague-Dawley rats with chemically induced diabetes. A secondary aim was to explore other hematological biomarkers of hepatic, cardiac, and renal function. Sixty-three male Sprague-Dawley rats were randomized into standard diet groups, normal control (NCON) (n = 21) and diabetic control (DCON) (n = 21), and a diabetic sesame oil (DSO) (n = 21) group, which were fed a diet containing 12% WSSO. Blood samples were analyzed at 0, 30, and 60 days. Differences between groups and across days were assessed with two-way repeated measures analysis of variance. At baseline, GLU and INS were similar in both diabetic groups, mean 248.4 ± 2.8 mg/dL and mean 23.4 ± 0.4 µU/mL, respectively. At 60 days, GLU was significantly (P < .05) higher in DCON (298.0 ± 2.3 mg/dL) compared with DSO (202.1 ± 1.0 mg/dL). INS showed similar favorable trends after WSSO supplementation. Consumption of WSSO significantly improved glucose control and other biomarkers of hepatic stress, as well as cardiac and renal health. WSSO may be a viable functional food to help reduce the detrimental effects of diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/fisiopatologia
Rim/fisiopatologia
Fígado/metabolismo
Miocárdio/metabolismo
Óleo de Gergelim/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Glicemia/metabolismo
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/metabolismo
Seres Humanos
Insulina/metabolismo
Rim/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
Sesamum/química
Sesamum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Insulin); 8008-74-0 (Sesame Oil)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.0065


  10 / 393 MEDLINE  
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[PMID]:28283159
[Au] Autor:Chan JC; Peters RL; Koplin JJ; Dharmage SC; Gurrin LC; Wake M; Tang ML; Prescott S; Allen KJ; HealthNuts Study
[Ad] Endereço:Murdoch Childrens Research Institute, Parkville, Victoria, Australia; Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
[Ti] Título:Food Challenge and Community-Reported Reaction Profiles in Food-Allergic Children Aged 1 and 4 Years: A Population-Based Study.
[So] Source:J Allergy Clin Immunol Pract;5(2):398-409.e3, 2017 Mar - Apr.
[Is] ISSN:2213-2201
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oral food challenge is the main tool for diagnosing food allergy, but there is little data on the reaction profiles of young children undergoing challenges, nor how these reactions compare to reactions on accidental ingestion in the community. OBJECTIVES: To compare reaction profiles from food challenges and parent-reported reactions on accidental ingestion, and assess predictors of severe reactions. METHODS: HealthNuts is a longitudinal population-based cohort study of 5276 1-year-old infants. Infants underwent skin prick tests and those with identifiable wheals were offered food challenges. Food challenges were repeated at age 4 years in those with previous food allergy or reporting new food allergies. Community-reported reactions were ascertained from parent questionnaires. RESULTS: Food challenges were undertaken in 916 children at age 1 year and 357 children at age 4 years (a total of 2047 peanut, egg, or sesame challenges). Urticaria was the most common sign in positive challenges at both ages (age 1 year, 88.7%, and age 4 years, 71.2%) although angioedema was significantly more common at age 4 years (40.1%) than at age 1 year (12.9%). Anaphylaxis was equally uncommon at both ages (2.1% and 2.8% of positive challenges at ages 1 and 4 years, respectively) but more common for peanut than for egg (4.5% and 1.2% of positive challenges at ages 1 and 4 years, respectively). The patterns of presenting signs reported during community reactions were similar to those observed in formal food challenges. Serum food-specific IgE levels of 15 kU/L or more were associated with moderate to severe reactions but skin prick test was not. CONCLUSIONS: There was a shift from the most common presenting reaction of urticaria during food challenges toward more angioedema in older children. Serum food-specific IgE levels were associated with reaction severity.
[Mh] Termos MeSH primário: Anafilaxia/prevenção & controle
Hipersensibilidade a Ovo/diagnóstico
Hipersensibilidade a Amendoim/diagnóstico
Sesamum/imunologia
[Mh] Termos MeSH secundário: Administração Oral
Alérgenos/imunologia
Anafilaxia/etiologia
Arachis/imunologia
Pré-Escolar
Estudos de Coortes
Hipersensibilidade a Ovo/complicações
Ovos/efeitos adversos
Feminino
Seres Humanos
Imunização/efeitos adversos
Imunização/métodos
Imunoglobulina E/sangue
Lactente
Masculino
Hipersensibilidade a Amendoim/complicações
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE



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