Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.700 [Categoria DeCS]
Referências encontradas : 20 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2 ir para página        

  1 / 20 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28744911
[Au] Autor:Xiang Y; Jing Z; Haixia W; Ruitao Y; Huaixiu W; Zenggen L; Lijuan M; Yiping W; Yanduo T
[Ad] Endereço:Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, 810001, China.
[Ti] Título:Antiproliferative Activity of Phenylpropanoids Isolated from Lagotis brevituba Maxim.
[So] Source:Phytother Res;31(10):1509-1520, 2017 Oct.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to evaluate the antiproliferative effect of phenylpropanoids isolated from the n-BuOH-soluble fraction of an ethanolic extract of Lagotis brevituba Maxim. The phenylpropanoids were identified as echinacoside, lagotioside, glucopyranosyl(1-6)martynoside, plantamoside, and verbascoside. Three of the compounds, lagotioside, glucopyranosyl(1-6)martynoside, and plantamoside, were isolated from L. brevituba for the first time. The antiproliferative activity of the isolates was evaluated in human gastric carcinoma (MGC-803), human colorectal carcinoma (HCT116), human hepatocellar carcinoma (HepG2), and human lung cancer (HCT116) cells using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Plantamoside showed promising activity against MGC-803 cells, with a half maximal inhibitory concentration value of 37.09 µM. The mechanism of the pro-apoptosis effect of plantamoside was then evaluated in MGC-803 cells. Changes in cell morphology, including disorganization of the architecture of actin microfilaments and formation of apoptotic bodies, together with cell cycle arrest in G2/M phases, were observed after treatment of plantamoside. The antiproliferative and pro-apoptotic effects were associated with a decrease in the ratio of Bcl-2/Bax and reduced mitochondrial membrane potential, which was accompanied by the release of reactive oxygen species and Ca into the cytoplasm. Taken together, the results indicated that plantamoside promotes apoptosis via a mitochondria-dependent mechanism. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Plantaginaceae/química
[Mh] Termos MeSH secundário: Fase G2
Glucosídeos/química
Glicosídeos/química
Células HCT116
Células Hep G2
Seres Humanos
Estrutura Molecular
Fenóis/química
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucosides); 0 (Glycosides); 0 (Phenols); 0 (Reactive Oxygen Species); 0 (lagotisoside A); 0 (martynoside); 3TGX09BD5B (acteoside)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5875


  2 / 20 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28589423
[Au] Autor:Kelly CA; Bowers MD
[Ad] Endereço:Department of Ecology and Evolutionary Biology and, University of Colorado Museum of Natural History, University of Colorado Boulder, UCB 334, Boulder, CO, 80309, USA. caitlin.a.kelly@colorado.edu.
[Ti] Título:The Perennial Penstemon: Variation in Defensive Chemistry Across Years, Populations, and Tissues.
[So] Source:J Chem Ecol;43(6):599-607, 2017 Jun.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plants produce a variety of secondary metabolites that function as a defense against their natural enemies. Production of these secondary metabolites is genetically controlled, but is also phenotypically plastic and varies in response to both biotic and abiotic factors. Therefore, plant species may vary widely in their chemical defenses and such variation can be evident at temporal, spatial and tissue levels. Focusing on the chemical defenses of a native Colorado wildflower, Penstemon virgatus, we assessed the variation in iridoid glycoside (IG) content across two non-consecutive growing seasons, six natural populations and three tissue types: leaves, stems and flowers. Our results indicate that P. virgatus plants contain high concentrations of IGs (mean = 23.36% dry weight of leaves) and that IGs were differentially allocated among tissue types. Leaves contained the highest concentration of IGs, which varied quantitatively between sampling years, among plant populations, and plant parts. We also quantified leaf herbivore damage at all six populations but we found very little herbivore damage. Our study indicates that the IG concentrations of P. virgatus plants are both spatially and temporally variable. Furthermore, the high concentrations of secondary metabolites combined with the low levels of damage suggest that these plants are well defended against generalist herbivores.
[Mh] Termos MeSH primário: Herbivoria
Glicosídeos Iridoides/química
Iridoides/química
Penstemon/química
Penstemon/metabolismo
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa
Flores/química
Flores/metabolismo
Glicosídeos Iridoides/metabolismo
Iridoides/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
Caules de Planta/química
Caules de Planta/metabolismo
Plantaginaceae/química
Compostos Orgânicos Voláteis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoid Glycosides); 0 (Iridoids); 0 (Volatile Organic Compounds); 0 (scutelloside)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0854-8


  3 / 20 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28582433
[Au] Autor:Baranzelli MC; Cosacov A; Ferreiro G; Johnson LA; Sérsic AN
[Ad] Endereço:Laboratorio de Ecología Evolutiva-Biología Floral, Instituto Multidisciplinario de Biología Vegetal (IMBIV), CONICET-Universidad Nacional de Córdoba, Córdoba, Argentina.
[Ti] Título:Travelling to the south: Phylogeographic spatial diffusion model in Monttea aphylla (Plantaginaceae), an endemic plant of the Monte Desert.
[So] Source:PLoS One;12(6):e0178827, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Effects of Pleistocene climatic oscillations on plant phylogeographic patterns are relatively well studied in forest, savanna and grassland biomes, but such impacts remain less explored on desert regions of the world, especially in South America. Here, we performed a phylogeographical study of Monttea aphylla, an endemic species of the Monte Desert, to understand the evolutionary history of vegetation communities inhabiting the South American Arid Diagonal. We obtained sequences of three chloroplast (trnS-trnfM, trnH-psbA and trnQ-rps16) and one nuclear (ITS) intergenic spacers from 272 individuals of 34 localities throughout the range of the species. Population genetic and Bayesian coalescent analyses were performed to infer genealogical relationships among haplotypes, population genetic structure, and demographic history of the study species. Timing of demographic events was inferred using Bayesian Skyline Plot and the spatio-temporal patterns of lineage diversification was reconstructed using Bayesian relaxed diffusion models. Palaeo-distribution models (PDM) were performed through three different timescales to validate phylogeographical patterns. Twenty-five and 22 haplotypes were identified in the cpDNA and nDNA data, respectively. that clustered into two main genealogical lineages following a latitudinal pattern, the northern and the southern Monte (south of 35° S). The northern Monte showed two lineages of high genetic structure, and more relative stable demography than the southern Monte that retrieved three groups with little phylogenetic structure and a strong signal of demographic expansion that would have started during the Last Interglacial period (ca. 120 Ka). The PDM and diffusion models analyses agreed in the southeast direction of the range expansion. Differential effect of climatic oscillations across the Monte phytogeographic province was observed in Monttea aphylla lineages. In northern Monte, greater genetic structure and more relative stable demography resulted from a more stable climate than in the southern Monte. Pleistocene glaciations drastically decreased the species area in the southern Monte, which expanded in a southeastern direction to the new available areas during the interglacial periods.
[Mh] Termos MeSH primário: DNA de Cloroplastos/genética
DNA Mitocondrial/genética
Modelos Estatísticos
Filogenia
Dispersão Vegetal/fisiologia
Plantaginaceae/genética
[Mh] Termos MeSH secundário: Argentina
Teorema de Bayes
Clima Desértico
Variação Genética
Haplótipos
História do Século XXI
História Antiga
Filogeografia
Plantaginaceae/classificação
Análise Espaço-Temporal
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast); 0 (DNA, Mitochondrial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178827


  4 / 20 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27700190
[Au] Autor:Yuan X; Wen H; Cui Y; Fan M; Liu Z; Mei L; Shao Y; Wang Y; Tao Y
[Ad] Endereço:a Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology , Chinese Academy of Sciences , Xining , P.R. China.
[Ti] Título:Phenolics from Lagotis brevituba Maxim.
[So] Source:Nat Prod Res;31(3):362-366, 2017 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation on Lagotis brevituba led to the isolation and characterisation of 11 phenolic compounds: p-hydroxy-benzoic acid 1, methyl 3,4-dihydroxybenzoate 2, vanillic acid 3, protocatechuic acid 4, caffeic acid 5, glucose ester of (E)-ferulic acid 6, p-coumaric acid 7, vanillin 8, diosmetin-7-O-ß-d-glucoside 9, chrysoeriol 10 and luteolin 11. Their structures were elucidated using spectroscopic methods and by comparison with data in the literature. Compounds 1-6 were first obtained from the genus Lagotis, and compounds 1-9 were isolated from L. brevituba for the first time. Compound 4 and 11 displayed remarkable antioxidant activities against DPPH radical (IC = 5.60 ± 0.09, 27.5 ± 0.06 mg/L, respectively), which were superior to positive control rutin. And compound 11 was also superior to rutin in ABTS assay (IC = 2.04 ± 0.13 mg/L).
[Mh] Termos MeSH primário: Antioxidantes/química
Fenóis/química
Plantaginaceae/química
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
Ácidos Cafeicos/química
Ácidos Cafeicos/isolamento & purificação
Ácidos Cumáricos/química
Ácidos Cumáricos/isolamento & purificação
Flavonoides/química
Flavonoides/isolamento & purificação
Glucosídeos/química
Glucosídeos/isolamento & purificação
Hidroxibenzoatos/química
Hidroxibenzoatos/isolamento & purificação
Luteolina/química
Luteolina/isolamento & purificação
Estrutura Molecular
Fenóis/isolamento & purificação
Extratos Vegetais/análise
Extratos Vegetais/química
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Caffeic Acids); 0 (Coumaric Acids); 0 (Flavonoids); 0 (Glucosides); 0 (Hydroxybenzoates); 0 (Phenols); 0 (Plant Extracts); 0 (methyl 3,4-dihydroxybenzoate); 36R5QJ8L4B (protocatechuic acid); AVM951ZWST (ferulic acid); KUX1ZNC9J2 (Luteolin); TWZ37241OT (diosmetin); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


  5 / 20 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27876335
[Au] Autor:Ghlissi Z; Kallel R; Sila A; Harrabi B; Atheymen R; Zeghal K; Bougatef A; Sahnoun Z
[Ad] Endereço:Research Unit of Pharmacology and Toxicology of Xenobiotics, Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisie. Electronic address: ghlissi_zohra@yahoo.fr.
[Ti] Título:Globularia alypum methanolic extract improves burn wound healing process and inflammation in rats and possesses antibacterial and antioxidant activities.
[So] Source:Biomed Pharmacother;84:1488-1495, 2016 Dec.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Burns are known as one of the most common and destructive forms of injury with a vast spectrum of consequences. Despite the discovery of various antibacterial and antiseptic agents, burn wound healing still has remained a challenge to modern medicine. Plants have been considered as potential agents for prevention and treatment of disorders in recent years. Globularia alypum L. (GA) is widely used in folk medicine against skin diseases and abscesses, however there is no scientific evidence justifying its use. This study aimed to evaluate the wound healing and anti-inflammatory effect, the antibacterial and antioxidant activities, as well as the chemical compositions of GA methanolic extract (GAME). Chemical compounds of GAME were examined by GC-MS. Wound healing effect was assessed by second-degree burn wounds in rats, anti-inflammatory activity was studied by carrageenan-induced rat paw edema, antioxidant activity was estimated by the DPPH, reducing power and ß-carotene tests and antimicrobial activity was tested against 6 bacteria. A total of 17 compounds were identified. GAME-treated rats showed an improvement in healing process and carrageenan-induced hind paws edema as assessed by histological and biochemical investigations, compared to the control. A significant antioxidant and antibacterial activities were also observed in GAME-treated rats. GAME revealed a burn wound healing activity probably due to the anti-inflammatory, antimicrobial and antioxidant activities of its phytochemical contents. Thus, this study confirms its traditional use, however further more precise studies are needed for future clinical application.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
Plantaginaceae
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/isolamento & purificação
Antibacterianos/uso terapêutico
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/uso terapêutico
Antioxidantes/isolamento & purificação
Antioxidantes/uso terapêutico
Inflamação/tratamento farmacológico
Inflamação/metabolismo
Masculino
Metanol/farmacologia
Metanol/uso terapêutico
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Folhas de Planta
Ratos
Ratos Wistar
Cicatrização/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Plant Extracts); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


  6 / 20 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27665125
[Au] Autor:Heckenroth A; Rabier J; Dutoit T; Torre F; Prudent P; Laffont-Schwob I
[Ad] Endereço:Aix Marseille Univ, Avignon Université, CNRS, IRD, IMBE, Marseille, France; ORTEC OGD - Ortec Générale de Dépollution, Parc de Pichaury, 550 rue Pierre Berthier, CS 80348, 13799 Aix en Provence Cedex 3, France.
[Ti] Título:Selection of native plants with phytoremediation potential for highly contaminated Mediterranean soil restoration: Tools for a non-destructive and integrative approach.
[So] Source:J Environ Manage;183(Pt 3):850-863, 2016 Dec 01.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to develop an effective and non-destructive method for the selection of native Mediterranean plants with phytoremediation potential based on their spontaneous recovery capacities. The study site consisted in a mixed contaminated soils (As, Cu, Pb, Sb, Zn) in the vicinity of a former lead smelting factory abandoned since 1925 in the Calanques National Park (Marseille, southeastern France). We developed an integrated characterization approach that takes into account topsoil metal(loid)s (MM) contamination, plant community composition and structure and mesologic parameters without using destructive methods. From a statistical selection of significant environmental descriptors, plant communities were described and interpreted as the result of spontaneous recovery under multiple stresses and local conditions (both natural and anthropogenic). We collected phytoecological and MM topsoil data using field monitoring and geographic information system (GIS) on a pollution hotspot where natural plant communities occur. The results of the multivariate analysis performed between species and descriptors indicated that a century of MM pollution pressure produced a significant correlation with plant community dynamics in terms of composition, diversity and structure, leading to the co-occurrence of different plant succession stages. Thus, these successions seemed linked to the variability of anthropogenic disturbance regimes within the study site. We recorded high topsoil contamination heterogeneity at the scale both of the plot and of the whole study area that suggested a heterogeneous MM distribution pattern dependent on the source of contaminants and site environmental variability. We identified 4 spontaneous plant communities co-occurring through a MM contamination gradient that could be used later from degraded to reference communities to define ecological restoration target combined to phytoremediation applications with respect to local conditions. Our results suggested that some of the native plant species such as Coronilla juncea and Globularia alypum might be tolerant to high mixed MM soil concentrations and they could thus be used for phytostabilization purposes in polluted Mediterranean areas in regard to their life-traits. Our non-destructive methodology led both to the selection of tolerant native plant species and communities and identification of highly polluted priority intervention areas through the study site where phytostabilization should be implemented. Furthermore, by analyzing succession dynamics linked to contamination patterns throughout the area and spontaneous recovery of native tolerant vegetation, our methodology opens up broad perspectives and research fields for ecological restoration for Mediterranean protected and contaminated areas based on ecosystem trajectories and new approaches for the integrative management of polluted soils.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Poluição Ambiental
Plantas
[Mh] Termos MeSH secundário: Ecossistema
Fabaceae
França
Metais/análise
Plantaginaceae
Plantas/metabolismo
Solo/química
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals); 0 (Soil); 0 (Soil Pollutants)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160926
[St] Status:MEDLINE


  7 / 20 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27617995
[Au] Autor:La Bella A; Leonelli F; Migneco LM; Marini Bettolo R
[Ad] Endereço:Dipartimento di Chimica, Università degli Studi di Roma "La Sapienza", P.le Aldo Moro, 5, I-00185 Roma, Italy. angela.labella@uniroma1.it.
[Ti] Título:(+)-Podocarpic Acid as Chiral Template in the Synthesis of Aphidicolane, Stemodane and Stemarane Diterpenoids †.
[So] Source:Molecules;21(9), 2016 Sep 08.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this review the synthetic work in the field of aphidicolane, stemodane and stemarane diterpenoids, in which readily available (+)-podocarpic acid (4) was used as chiral template for the construction of their polycyclic structures, is described as it developed along the years. In the frame of this work (+)-podocarpic acid (4) was a very useful tool in a model study leading to the syntheses of tetracyclic ketones 7 and 8, models of key intermediates 5a and 6 in the syntheses of (+)-aphidicolin (1) and (+)-stemodin (2a), respectively. (+)-Podocarpic acid (4) was also converted into (+)-2-deoxystemodinone (2d), allowing confirmation of the stemodane diterpenoids absolute configuration, into (+)-aphidicol-15-ene (36) and into Stemodia chilensis tetracyclic diterpenoid (+)-19-acetoxystemodan-12-ol (2f), allowing confirmation of its structure. (+)-Podocarpic acid (4) was then extensively used in the work which led to the synthesis of (+)-stemar-13-ene (57) and (+)-18-deoxystemarin (3b). Finally, (+)-4 was converted into (+)-2-deoxyoryzalexin S (66), which made it possible to demonstrate that the structure of (+)-66 could not be attributed to a Chilean Calceolaria isolated diterpenoid to which this structure had been assigned.
[Mh] Termos MeSH primário: Calceolariaceae/química
Diterpenos Abietanos/química
Diterpenos Abietanos/síntese química
Plantaginaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Diterpenes, Abietane); 7K80G5Z96Y (podocarpic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE


  8 / 20 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27363265
[Au] Autor:Yang B; Hou Q; Hu F; Zhang F
[Ad] Endereço:Gansu Key Laboratory for Molecular Medicine and Prevention and Treatment of Traditional Chinese Medicine for Major Diseases, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.
[Ti] Título:[Total flavones derived from Lagotis brevituba maxim reduce the levels of inflammatory cytokines in cerebral cortex and hippocampus of Alzheimer's disease mice].
[So] Source:Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi;32(7):881-5, 2016 Jul.
[Is] ISSN:1007-8738
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Objective To investigate the mechanism behind the treatment of Alzheimer's disease (AD) with total flavones derived from Lagotis brevituba maxim (TF-LBM). Methods Fifty SAMP8 mice (aged 8 months) were randomly divided into 5 groups, (150, 300, 600) mg/kg TF-LBM groups, 0.65 g/kg donepezil HCl group and AD model group; 10 SAMR1 mice (aged 8 months) were used as a control group of normal aging. The AD model group and the normal aging control group were given the same volume of distilled water as TF-LBM groups. Eight weeks after intragastric administration, Morris water maze experiment was conducted to calculate the latency of place navigation. After the behavioral experiment, the brain cortical tissue and hippocampus (CA1 region) of the mice from various groups were taken to observe the morphological changes of the cortical tissue and hippocampus and test IL-1ß, IL-6, TNF-α content. Results Compared with the model group, the escape latency of the normal aging group, the high-dose TF-LBM group and the donepezil HCl group were evidently shortened; compared with the normal aging group, IL-1ß, IL-6, TNF-αof the model group increased significantly; compared with the model group, IL-1ß content of the low-dose TF-LBM group had no obvious difference, while IL-1ß content of the median-dose and high-dose TF-LBM groups and the donepezil HCl group decreased significantly; IL-6 content decreased in all TF-LBM groups and the donepezil HCl group; TNF-α level in the low-dose and median-dose TF-LBM groups had no evident difference, while it was reduced significantly in the high-dose TF-LBM group and the donepezil HCl group. Compared with the normal aging group, IL-1ß, IL-6 and TNF-α content of the model group increased significantly; compared with the model group, IL-1ß, IL-6 and TNF-α content of all TF-LBM groups and the donepezil HCl group decreased. Conclusion TF-LBM can improve the behavior change of SAMP8 mice with AD. TF-LBM can reduce the content of IL-6, IL-1ß and TNF-α in cerebral cortex and hippocampus CA1.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Região CA1 Hipocampal/efeitos dos fármacos
Córtex Cerebral/efeitos dos fármacos
Citocinas/metabolismo
Flavonas/farmacologia
Plantaginaceae/química
[Mh] Termos MeSH secundário: Doença de Alzheimer/metabolismo
Análise de Variância
Animais
Região CA1 Hipocampal/metabolismo
Córtex Cerebral/metabolismo
Modelos Animais de Doenças
Seres Humanos
Mediadores da Inflamação/metabolismo
Interleucina-1beta/metabolismo
Interleucina-6/metabolismo
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
Camundongos
Fitoterapia
Extratos Vegetais/farmacologia
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Flavones); 0 (Inflammation Mediators); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE


  9 / 20 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27192708
[Au] Autor:Ellis TJ; Field DL
[Ad] Endereço:IST Austria, Am Campus 1, 3400 Klosterneuburg, Austria Evolutionary Biology Centre, Norbyvägen 18D, Uppsala University, 75236 Uppsala, Sweden thomas.ellis@ebc.uu.se.
[Ti] Título:Repeated gains in yellow and anthocyanin pigmentation in flower colour transitions in the Antirrhineae.
[So] Source:Ann Bot;117(7):1133-40, 2016 Jun.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Angiosperms display remarkable diversity in flower colour, implying that transitions between pigmentation phenotypes must have been common. Despite progress in understanding transitions between anthocyanin (blue, purple, pink or red) and unpigmented (white) flowers, little is known about the evolutionary patterns of flower-colour transitions in lineages with both yellow and anthocyanin-pigmented flowers. This study investigates the relative rates of evolutionary transitions between different combinations of yellow- and anthocyanin-pigmentation phenotypes in the tribe Antirrhineae. METHODS: We surveyed taxonomic literature for data on anthocyanin and yellow floral pigmentation for 369 species across the tribe. We then reconstructed the phylogeny of 169 taxa and used phylogenetic comparative methods to estimate transition rates among pigmentation phenotypes across the phylogeny. KEY RESULTS: In contrast to previous studies we found a bias towards transitions involving a gain in pigmentation, although transitions to phenotypes with both anthocyanin and yellow taxa are nevertheless extremely rare. Despite the dominance of yellow and anthocyanin-pigmented taxa, transitions between these phenotypes are constrained to move through a white intermediate stage, whereas transitions to double-pigmentation are very rare. The most abundant transitions are between anthocyanin-pigmented and unpigmented flowers, and similarly the most abundant polymorphic taxa were those with anthocyanin-pigmented and unpigmented flowers. CONCLUSIONS: Our findings show that pigment evolution is limited by the presence of other floral pigments. This interaction between anthocyanin and yellow pigments constrains the breadth of potential floral diversity observed in nature. In particular, they suggest that selection has repeatedly acted to promote the spread of single-pigmented phenotypes across the Antirrhineae phylogeny. Furthermore, the correlation between transition rates and polymorphism suggests that the forces causing and maintaining variance in the short term reflect evolutionary processes on longer time scales.
[Mh] Termos MeSH primário: Antocianinas/metabolismo
Flores/fisiologia
Plantaginaceae/fisiologia
[Mh] Termos MeSH secundário: Evolução Biológica
Filogenia
Pigmentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160519
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcw043


  10 / 20 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:27145608
[Au] Autor:Richardson LL; Bowers MD; Irwin RE
[Ti] Título:Nectar chemistry mediates the behavior of parasitized bees: consequences for plant fitness.
[So] Source:Ecology;97(2):325-37, 2016 Feb.
[Is] ISSN:0012-9658
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plants produce an array of secondary metabolites that play important ecological roles as anti-herbivore and anti-pathogen defenses. Many herbivores experience physiological costs when they consume secondary metabolites, yet some also benefit, for example when these chemicals confer resistance to parasites and predators. Secondary metabolites are often present in nectar and pollen, which is paradoxical given that floral rewards are important in the attraction of mutualists rather than deterrence of antagonists. Motivated by studies of interactions among plants, herbivores, and parasites, as well as research showing that secondary metabolites can reduce bee disease, we characterized the occurrence of two iridoid glycosides, aucubin and catalpol, in floral rewards and other tissues of the bee pollinated plant, Chelone glabra. We then experimentally investigated effects of nectar iridoid glycoside concentrations on the foraging behavior of bumble bee pollinators naturally afflicted by a parasitoid fly and a protozoan intestinal parasite, and subsequent effects on an estimate of plant reproduction. We found that floral nectar had lower iridoid glycoside concentrations than leaves, pollen, and corollas, and that, compared to those plant parts, the relative ratio of the two primary iridoid glycosides, aucubin and catalpol, was reversed in nectar. Whether bees carried parasitoid fly larvae did not affect their response to nectar chemistry; however, there was a significant interaction between protozoan parasite infection and nectar treatment, with infected bees foraging longer at flowers with high compared to low nectar iridoid glycoside concentrations. Parasitized bees were also more likely to return to inflorescences with high iridoid glycoside nectar. Consequently, flowers in the high iridoid glycoside nectar treatment donated significantly more pollen to conspecific stigmas than did flowers in the low iridoid glycoside treatment, suggesting an increase in male plant fitness. Taken together, these results demonstrate that nectar secondary metabolites can mediate the behavior of pollinators with subsequent benefits for estimates of plant reproduction.
[Mh] Termos MeSH primário: Abelhas/parasitologia
Comportamento Animal/fisiologia
Dípteros/fisiologia
Néctar de Plantas/química
Plantaginaceae/fisiologia
Trypanosomatina/fisiologia
[Mh] Termos MeSH secundário: Animais
Interações Hospedeiro-Parasita
Glicosídeos Iridoides/química
Masculino
Polinização
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Iridoid Glycosides); 0 (Plant Nectar)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160505
[Lr] Data última revisão:
160505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE



página 1 de 2 ir para página        
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde