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[PMID]:27837029
[Au] Autor:Tesselaar MH; Crezee T; Swarts HG; Gerrits D; Boerman OC; Koenderink JB; Stunnenberg HG; Netea MG; Smit JW; Netea-Maier RT; Plantinga TS
[Ad] Endereço:Department of Pathology, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.
[Ti] Título:Digitalis-like Compounds Facilitate Non-Medullary Thyroid Cancer Redifferentiation through Intracellular Ca2+, FOS, and Autophagy-Dependent Pathways.
[So] Source:Mol Cancer Ther;16(1):169-181, 2017 Jan.
[Is] ISSN:1538-8514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Up to 20%-30% of patients with metastatic non-medullary thyroid cancer have persistent or recurrent disease resulting from tumor dedifferentiation. Tumor redifferentiation to restore sensitivity to radioactive iodide (RAI) therapy is considered a promising strategy to overcome RAI resistance. Autophagy has emerged as an important mechanism in cancer dedifferentiation. Here, we demonstrate the therapeutic potential of autophagy activators for redifferentiation of thyroid cancer cell lines. Five autophagy-activating compounds, all known as digitalis-like compounds, restored hNIS expression and iodide uptake in thyroid cancer cell lines. Upregulation of hNIS was mediated by intracellular Ca and FOS activation. Cell proliferation was inhibited by downregulating AKT1 and by induction of autophagy and p21-dependent cell-cycle arrest. Digitalis-like compounds, also designated as cardiac glycosides for their well-characterized beneficial effects in the treatment of heart disease, could therefore represent a promising repositioned treatment modality for patients with RAI-refractory thyroid carcinoma. Mol Cancer Ther; 16(1); 169-81. ©2016 AACR.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Autofagia/efeitos dos fármacos
Cálcio/metabolismo
Digitalis/química
Proteínas Proto-Oncogênicas c-fos/metabolismo
Transdução de Sinais/efeitos dos fármacos
Neoplasias da Glândula Tireoide/metabolismo
Neoplasias da Glândula Tireoide/patologia
[Mh] Termos MeSH secundário: Fator 3 Ativador da Transcrição/metabolismo
Antineoplásicos Fitogênicos/farmacocinética
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Diferenciação Celular/efeitos dos fármacos
Diferenciação Celular/genética
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/genética
Análise por Conglomerados
Perfilação da Expressão Gênica
Seres Humanos
Simportadores/metabolismo
Neoplasias da Glândula Tireoide/genética
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Activating Transcription Factor 3); 0 (Antineoplastic Agents, Phytogenic); 0 (Proto-Oncogene Proteins c-fos); 0 (Symporters); 0 (sodium-iodide symporter); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE
[do] DOI:10.1158/1535-7163.MCT-16-0460


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[PMID]:27908913
[Au] Autor:Vithayathil MK; Edwards M
[Ad] Endereço:Department of Accident and Emergency, King's College Hospital, London, UK.
[Ti] Título:Comfrey herbal remedy causing second-degree heart block: do not be outfoxed by digitalis.
[So] Source:BMJ Case Rep;2016, 2016 Dec 01.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A previously well woman aged 63 years presents to the emergency department with vomiting, palpitations and 3 presyncopal episodes. She had no previous medical or cardiac history, with the patient stating that she tried a herbal remedy of boiled comfrey leaves for insomnia 18 hours before arrival to the department. Her ECG showed multiple abnormalities, including bradycardia, second-degree atrioventricular node block, Mobitz Type 2, a shortened QT interval, downsloping ST depression and presence of U waves. After viewing the images of comfrey and foxglove, it highlighted the possibility of mistaken ingestion of Digitalis, containing the organic forms of cardiac glycosides, such as digoxin and digitoxin. Raised serum digoxin levels confirmed this. The patient was haemodynamically stable, and given digoxin-binding antibodies. After 5 days of cardiac monitoring, her ECG returned to normal rhythm, and she was discharged home.
[Mh] Termos MeSH primário: Acidentes
Anticorpos Heterófilos/uso terapêutico
Bloqueio Atrioventricular/induzido quimicamente
Confrei
Digitalis/envenenamento
Digoxina/envenenamento
Intoxicação por Plantas/diagnóstico
Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico
[Mh] Termos MeSH secundário: Anticorpos Heterófilos/imunologia
Bradicardia/etiologia
Digitalis/imunologia
Digoxina/imunologia
Eletrocardiografia
Feminino
Seres Humanos
Meia-Idade
Folhas de Planta/envenenamento
Intoxicação por Plantas/complicações
Intoxicação por Plantas/tratamento farmacológico
Plantas Medicinais
Resultado do Tratamento
Vômito/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Heterophile); 73K4184T59 (Digoxin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


  3 / 1001 MEDLINE  
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[PMID]:27295921
[Au] Autor:Verma SK; Sahin G; Gurel E
[Ti] Título:Somatic embryogenesis, pigment accumulation, and synthetic seed production in Digitalis davisiana Heywood.
[So] Source:Indian J Exp Biol;54(4):245-53, 2016 Apr.
[Is] ISSN:0019-5189
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Digitalis davisiana, commonly called Alanya foxglove, from Turkey, is an important medicinal herb as the main source of cardiac glycosides, cardenolides, anthraquinones, etc. It is also known in the Indian Medicine for treatment of wounds and burns. It has ornamental value as well. Overexploitation of D. davisiana has led this species to be declared protected, and thereby encouraged various methods for its propagation. In this study, an optimized and efficient plant tissue culture protocol was established using cotyledonary leaf, hypocotyl and root explants of D. davisiana. Callus tissues were obtained from the cotyledonary leaf, hypocotyl and root segments cultured on Murashige and Skoog's (MS) medium containing different plant growth regulators. The maximum number of somatic embryos were achieved by the MS medium containing 6-benzyladenine (1.0 mg/L BAP) or 2,4-dichlorophenoxy acetic acids (0.1 mg/L 2,4-D), which produced an average of 8.3 ± 1.5 or 5.3 ± 1.5 embryos per cotyledonary leaf, respectively. After 3 wk of culture in MS medium supplemented with 1.0 mg/L 2,4-D, callus showed a clear accumulation of orange pigmentation. Shoot regeneration was remarkably higher (14.3 indirect shoots) in a combination of α-naphthalene acetic acid (0.25 mg/L NAA) plus 3.0 mg/L BAP than 2.0 mg/L zeatin (10.3 ± 0.5 direct shoots) alone. The shoots were successfully rooted on MS medium supplemented with NAA (0.1-1.0 mg/L). In addition, synthetic seeds were produced by encapsulating shoot tips in 4% sodium alginate solution. Maximum conversion frequency of 76.6% was noted from encapsulated shoot tips cultured on 0.25 mg/L NAA with 1.0 mg/L BAP. The encapsulated shoot tips could be stored up to 60 days at 4 °C. Regenerated plantlets of D. davisiana were successfully acclimatized and transferred to soil. This study has demonstrated successful preservation of elite genotypes of D. davisiana.
[Mh] Termos MeSH primário: Digitalis/embriologia
Pigmentos Biológicos/metabolismo
Sementes/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Digitalis/metabolismo
Germinação
Brotos de Planta/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pigments, Biological)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160614
[Lr] Data última revisão:
160614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE


  4 / 1001 MEDLINE  
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[PMID]:27105421
[Au] Autor:Cingoz GS; Gurel E
[Ad] Endereço:Abant Izzet Baysal University, Faculty of Science and Art, Department of Biology, 14280, Bolu, Turkey. Electronic address: guncesahin@gmail.com.
[Ti] Título:Effects of salicylic acid on thermotolerance and cardenolide accumulation under high temperature stress in Digitalis trojana Ivanina.
[So] Source:Plant Physiol Biochem;105:145-149, 2016 Aug.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Long periods of high temperature or transitory increased temperature, a widespread agricultural problem, may lead to a drastic reduction in economic yield, affecting plant growth and development in many areas of the world. Heat stress causes many anatomical and physiological changes in plants. Its unfavorable effects can be alleviated by thermotolerance induced by exogenous application of plant growth regulators and osmoprotectants or by gradual application of temperature stress. Digitalis trojana Ivanina is an important medicinal plant species well known mainly for its cardenolides. The production of cardenolides via traditional agriculture is commercially inadequate. In this study, elicitation strategies were employed for improving crop thermotolerance and accumulation of cardenolides. For these purposes, the effects of salicylic acid (SA) and/or high temperature treatments in inducing cardenolide accumulation and thermotolerance were tested in callus cultures of D. trojana. Considerable increases in the production of cardenolides (up to 472.28 µg.g(-1) dry weight, dw) and induction of thermotolerance capacity were observed when callus cultures were exposed to high temperature for 2 h after pretreating with SA. High temperature treatments (2 h and 4 h) caused a marked reduction in superoxide dismutase (SOD; EC 1.15.1.1) and catalase (CAT; EC 1.11.1.6) activities, while SA pretreatment increased their activities. High temperature and/or SA appeared to increase the levels of proline, total phenolic, and flavonoid content. Elevated phenolic accumulation could be associated with increased stress protection. These results indicated that SA treatments induced synthesis of antioxidants and cardenolides, which may play a significant role in resistance to high temperature stress.
[Mh] Termos MeSH primário: Cardenolídeos/metabolismo
Digitalis/fisiologia
Ácido Salicílico/farmacologia
Estresse Fisiológico/efeitos dos fármacos
Temperatura Ambiente
Termotolerância/efeitos dos fármacos
[Mh] Termos MeSH secundário: Catalase/metabolismo
Digitalis/efeitos dos fármacos
Digitalis/enzimologia
Flavonoides/metabolismo
Fenóis/metabolismo
Prolina/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardenolides); 0 (Flavonoids); 0 (Phenols); 9DLQ4CIU6V (Proline); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); O414PZ4LPZ (Salicylic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160423
[St] Status:MEDLINE


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[PMID]:26913372
[Au] Autor:Abdul-Rahim AH; MacIsaac RL; Jhund PS; Petrie MC; Lees KR; McMurray JJ; On behalf the VICCTA-Heart Failure Collaborators
[Ad] Endereço:Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
[Ti] Título:Efficacy and safety of digoxin in patients with heart failure and reduced ejection fraction according to diabetes status: An analysis of the Digitalis Investigation Group (DIG) trial.
[So] Source:Int J Cardiol;209:310-6, 2016 Apr 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Digoxin is recommended in symptomatic heart failure patients with reduced ejection fraction (HF-REF) in sinus rhythm and refractory to other evidence-based therapy. Although HF-REF patients with diabetes have worse functional status than those without, the effects of digoxin have not been specifically evaluated according to diabetes status. METHODS: We examined the efficacy and safety of digoxin in HF-REF patients with and without diabetes in the Digitalis Investigation Group trial. Mortality from all-cause, cardiovascular (CV) causes and heart failure (HF), along with HF hospitalisation and suspected digoxin toxicity were analyzed according to diabetes status and randomised treatment assignment. RESULTS: Of the 6800 patients, those with diabetes (n=1933) were older, more often women, had worse clinical status and more co-morbidity than those without diabetes. All-cause and CV mortality were higher in patients with diabetes than in those without and digoxin did not reduce mortality in either sub-group. The rate of HF hospitalization (per 100 person-years) in patients with diabetes was higher than in those without and was reduced by digoxin in both patient groups: diabetes - placebo 20.5 and digoxin 16.0 (HR 0.79, 95% CI: 0.68-0.91); no diabetes - placebo 12.7 and digoxin 8.7 (HR 0.69, 0.62-0.77); interaction p=0.14. Suspected digoxin toxicity in patients randomised to digoxin was more common among patients with diabetes than without (6.5% versus 5.8%), as was hospitalisation for digoxin toxicity (1.4% versus 0.8%). CONCLUSION: Added to an ACE inhibitor, digoxin reduced HF hospitalisation in HF-REF patients with and without diabetes without a substantial risk of toxicity.
[Mh] Termos MeSH primário: Cardiotônicos/uso terapêutico
Digitalis
Digoxina/uso terapêutico
Insuficiência Cardíaca/tratamento farmacológico
Insuficiência Cardíaca/fisiopatologia
Volume Sistólico/efeitos dos fármacos
[Mh] Termos MeSH secundário: Idoso
Cardiotônicos/efeitos adversos
Cardiotônicos/farmacologia
Diabetes Mellitus/tratamento farmacológico
Diabetes Mellitus/epidemiologia
Diabetes Mellitus/fisiopatologia
Digoxina/efeitos adversos
Digoxina/farmacologia
Feminino
Insuficiência Cardíaca/epidemiologia
Hospitalização/tendências
Seres Humanos
Hiperpotassemia/induzido quimicamente
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Volume Sistólico/fisiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cardiotonic Agents); 73K4184T59 (Digoxin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160226
[St] Status:MEDLINE


  6 / 1001 MEDLINE  
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[PMID]:26902406
[Au] Autor:Durmaz I; Guven EB; Ersahin T; Ozturk M; Calis I; Cetin-Atalay R
[Ad] Endereço:Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey. Electronic address: durmaz@bilkent.edu.tr.
[Ti] Título:Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.
[So] Source:Phytomedicine;23(1):42-51, 2016 Jan 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hepatocellular carcinoma is the second deadliest cancer with limited treatment options. Loss of PTEN causes the P13K/Akt pathway to be hyperactive which contributes to cell survival and resistance to therapeutics in various cancers, including the liver cancer. Hence molecules targeting this pathway present good therapeutic strategies for liver cancer. HYPOTHESIS: It was previously reported that Cardiac glycosides possessed antitumor activity by inducing apoptosis of multiple cancer cells through oxidative stress. However, whether Cardiac glycoside Lanatoside C can induce oxidative stress in liver cancer cells and induce cell death both in vitro and in vivo remains unknown. METHODS: Cell viability was measured by SRB assay. Cell death analysis was investigated by propidium iodide staining with flow cytometry and PARP cleavage. DCFH-DA staining and cytometry were used for intracellular ROS measurement. Protein levels were analyzed by western blot analysis. Antitumor activity was investigated on mice xenografts in vivo. RESULTS: In this study, we found that Cardiac glycosides, particularly Lanatoside C from Digitalis ferruginea could significantly inhibit PTEN protein adequate Huh7 and PTEN deficient Mahlavu human liver cancer cell proliferation by the induction of apoptosis and G2/M arrest in the cells. Lanatoside C was further shown to induce oxidative stress and alter ERK and Akt pathways. Consequently, JNK1 activation resulted in extrinsic apoptotic pathway stimulation in both cells while JNK2 activation involved in the inhibition of cell survival only in PTEN deficient cells. Furthermore, nude mice xenografts followed by MRI showed that Lanatoside C caused a significant decrease in the tumor size. In this study apoptosis induction by Lanatoside C was characterized through ROS altered ERK and Akt pathways in both PTEN adequate epithelial and deficient mesenchymal liver cancer cells. CONCLUSION: The results indicated that Lanatoside C could be contemplated in liver cancer therapeutics, particularly in PTEN deficient tumors. This is due to Lanatoside C's stress inducing action on ERK and Akt pathways through differential activation of JNK1 and JNK2 by GSK3ß.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/patologia
Lanatosídeos/farmacologia
Neoplasias Hepáticas/patologia
PTEN Fosfo-Hidrolase/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Proliferação Celular
Digitalis/química
Seres Humanos
Camundongos
Camundongos Nus
Estresse Oxidativo
Transdução de Sinais
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lanatosides); 5RR3JFZ771 (lanatoside C); EC 3.1.3.67 (PTEN Phosphohydrolase); EC 3.1.3.67 (PTEN protein, human)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160224
[St] Status:MEDLINE


  7 / 1001 MEDLINE  
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[PMID]:26858347
[Au] Autor:Janssen RM; Berg M; Ovakim DH
[Ad] Endereço:Departments of Medicine (Janssen, Ovakim) and Emergency Medicine (Berg), University of British Columbia; British Columbia Drug and Poison Information Centre (Ovakim), Vancouver, BC renee.janssen@alumni.ubc.ca.
[Ti] Título:Two cases of cardiac glycoside poisoning from accidental foxglove ingestion.
[So] Source:CMAJ;188(10):747-50, 2016 Jul 12.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Antídotos/administração & dosagem
Arritmias Cardíacas/induzido quimicamente
Digitalis/envenenamento
Digoxina/sangue
Digoxina/toxicidade
[Mh] Termos MeSH secundário: Idoso
Digitalis/efeitos dos fármacos
Eletrocardiografia
Feminino
Seres Humanos
Hiperpotassemia
Masculino
Náusea
Vômito
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 73K4184T59 (Digoxin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160210
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.150676


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[PMID]:26526481
[Au] Autor:de Micheli Serra A; Pastelín Hernández G
[Ad] Endereço:Departamento de Farmacología, Instituto Nacional de Cardiología «Ignacio Chávez¼, México, D.F., México.
[Ti] Título:[A tribute to the memory of the illustrious maestro and academic Dr. Rafael Méndez Martínez, pioneer in the pharmacological studies of digitalis and digitalis glycosides].
[Ti] Título:Breve historia de la digital y los digitálicos. Homenaje a la memoria del ilustre maestro y académico Dr. Rafael Méndez Martínez, pionero de los estudios farmacológicos sobre la digital y los glucósidos digitálicos..
[So] Source:Gac Med Mex;151(5):660-5, 2015 Sep-Oct.
[Is] ISSN:0016-3813
[Cp] País de publicação:Mexico
[La] Idioma:spa
[Ab] Resumo:Since the end of the XVIII century, digitalis glycosides were employed in heart failure. They were considered initially as diuretics and later as cardiotonic agents or as positive inotropics. At the present time there are varied groups of positive inotropic agents, which have a beneficial action on the failing human myocardium. For example, the beta adrenergics, the phosphodiesterase III inhibitors such as milrinone, or the sensibilizers of myocardial proteins to Ca++ such as levosimendan and omecamtiv mecarbil. However, following the opinion of distinguished cardiologists, in the case of heart failure associated to atrial fibrillation, digitalis cannot be substituted.
[Mh] Termos MeSH primário: Glicosídeos Digitálicos/história
Digitalis
Farmacologia/história
[Mh] Termos MeSH secundário: História do Século XVI
História do Século XVIII
História do Século XIX
Seres Humanos
México
[Pt] Tipo de publicação:ENGLISH ABSTRACT; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Digitalis Glycosides)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151103
[Lr] Data última revisão:
151103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151104
[St] Status:MEDLINE


  9 / 1001 MEDLINE  
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[PMID]:26524901
[Au] Autor:Takahashi H
[Ti] Título:[Laboratory Medicine Learned Through Research on the Pathogenesis of Hypertension].
[So] Source:Rinsho Byori;63(5):612-22, 2015 May.
[Is] ISSN:0047-1860
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Laboratory tests used in clinical practice to assess hypertension include a differential diagnosis, the assessment of complications, and detection of adverse events with medication, which cover a variety of fields of laboratory medicine. I learned laboratory medicine through basic and clinical studies on the pathogenesis of hypertension, and summarized those findings and my interpretations. Basic research using animal models points to a causal role of the central nervous system in essential hypertension; however, since clinical research is technically difficult to perform, this connection has not been confirmed in humans. Recently, renal nerve ablation in humans proved to continuously decrease the blood pressure in the presence of resistant hypertension. Furthermore, when electrical stimulation was continuously applied to the carotid baroreceptor nerve of human adults, their blood pressure lowered. These findings promoted the concept that the central nervous system may actually be involved in the pathogenesis of essential hypertension, which is closely associated with excess sodium intake. We demonstrated that endogenous digitalis plays a key role in hypertension associated with excess sodium intake via sympathetic activation in rats. An increased sodium concentration inside the brain activates epithelial sodium channels and the renin-angiotensin-aldosterone system in the brain. Aldosterone releases ouabain from neurons in the paraventricular nucleus in the hypothalamus. Angiotensin II and aldosterone of peripheral origin reach the brain to augment sympathetic outflow. Collectively essential hypertension associated with excess sodium intake and obesity, renovascular hypertension, and primary aldosteronism and pseudoaldosteronism are all suggested to have a common cause originating from the central nervous system.
[Mh] Termos MeSH primário: Hipertensão/etiologia
Ciência de Laboratório Médico
Pesquisa
[Mh] Termos MeSH secundário: Animais
Barorreflexo/fisiologia
Sistema Nervoso Central/fisiologia
Digitalis/fisiologia
Canais Epiteliais de Sódio/fisiologia
Seres Humanos
Hiperaldosteronismo/complicações
Rim/inervação
Obesidade/complicações
Ouabaína/metabolismo
Sistema Renina-Angiotensina/fisiologia
Sódio na Dieta/efeitos adversos
Sistema Nervoso Simpático/fisiopatologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Epithelial Sodium Channels); 0 (Sodium, Dietary); 5ACL011P69 (Ouabain)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151103
[Lr] Data última revisão:
151103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151104
[St] Status:MEDLINE


  10 / 1001 MEDLINE  
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[PMID]:26228721
[Au] Autor:Pagliaro L; Colli A; Bobbio M
[Ti] Título:[Individual response to treatment: from Withering to contemporary medicine].
[Ti] Título:La risposta individuale ai trattamenti. Da Withering alla medicina di oggi..
[So] Source:Recenti Prog Med;106(7):308-15, 2015 Jul.
[Is] ISSN:0034-1193
[Cp] País de publicação:Italy
[La] Idioma:ita
[Ab] Resumo:This is an essay dealing with the 1785 cohort study by William Withering (the "account"), in which he reported the results of the treatment with foxglove (Digitalis purpurea) in 163 patients suffering from various forms of hydropsy (water retention). Withering reported the results of all patients, and classified them into responders and non-responders. He identified the responders as suffering from heart failure. In the 18th century, medical treatments were judged as successful if they complied with the criteria a priori of the theory of the four humors, and not on the patient's response to the treatment. Withering was the first not only to compare the patient's conditions before and after treatment, but also to identify the individual clinical characteristics of the patients who responded. In modern medicine, drugs are released on the market and approved for use after what is known as "population-derived clinical research", principally randomized controlled trials, and guidelines. More than 200 years ago, Withering anticipated the current and growing trend towards individual responses to treatment, and personalized medicine.
[Mh] Termos MeSH primário: Digitalis/química
Insuficiência Cardíaca/história
Medicina de Precisão/história
[Mh] Termos MeSH secundário: Edema/tratamento farmacológico
Edema/história
Insuficiência Cardíaca/tratamento farmacológico
História do Século XVIII
Seres Humanos
Medicina de Precisão/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1510
[Cu] Atualização por classe:160301
[Lr] Data última revisão:
160301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150801
[St] Status:MEDLINE
[do] DOI:10.1701/1940.21084



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