Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.583.990.855 [Categoria DeCS]
Referências encontradas : 62 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 7 ir para página                  

  1 / 62 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28278649
[Au] Autor:Kubica P; Szopa A; Ekiert H
[Ad] Endereço:a Department of Pharmaceutical Botany, Medical College , Jagiellonian University , Kraków , Poland.
[Ti] Título:Production of verbascoside and phenolic acids in biomass of Verbena officinalis L. (vervain) cultured under different in vitro conditions.
[So] Source:Nat Prod Res;31(14):1663-1668, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Methanolic extracts from the biomass of Verbena officinalis cultured under continuous artificial light and in darkness on 12 variants of the Murashige and Skoog medium containing different concentrations (0.5-3.0 mg/L) of plant growth regulators: 6-benzyladenine, kinetin, 1-naphthaleneacetic acid and indole-3-butyric acid, were analysed for the amounts of verbascoside and phenolic acids, before and after acid hydrolysis, using the HPLC-DAD method. The amounts of verbascoside were very high (max. 2454.12 mg/100 g DW - light, and 2135.59 mg/100 g DW - darkness). The total amounts of phenolic acids reached a maximum of 46.02 mg/100 g DW (free phenolic acids) and 141.05 mg/100 g DW (bound compounds). The main metabolites were: ferulic, o-coumaric and caffeic acids. The maximum amount of verbascoside was 3.28 times higher than in extracts from the herb of the parent plant. The cultures could be proposed as a potential biotechnological source for selected biologically active compounds.
[Mh] Termos MeSH primário: Biomassa
Hidroxibenzoatos/síntese química
Extratos Vegetais/química
Verbena/química
[Mh] Termos MeSH secundário: Compostos de Benzil
Ácidos Cafeicos/metabolismo
Cromatografia Líquida de Alta Pressão
Glucosídeos
Indóis
Cinetina
Ácidos Naftalenoacéticos
Fenóis
Reguladores de Crescimento de Planta/análise
Purinas
Verbena/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzyl Compounds); 0 (Caffeic Acids); 0 (Glucosides); 0 (Hydroxybenzoates); 0 (Indoles); 0 (Naphthaleneacetic Acids); 0 (Phenols); 0 (Plant Extracts); 0 (Plant Growth Regulators); 0 (Purines); 061SKE27JP (indolebutyric acid); 29656-58-4 (phenolic acid); 33T7G7757C (1-naphthaleneacetic acid); 3TGX09BD5B (acteoside); KXG6A989PS (benzylaminopurine); P39Y9652YJ (Kinetin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1286477


  2 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28118725
[Au] Autor:Kuok CF; Hoi SO; Hoi CF; Chan CH; Fong IH; Ngok CK; Meng LR; Fong P
[Ad] Endereço:School of Health Sciences, Macao Polytechnic Institute, Macao 999078, China.
[Ti] Título:Synergistic antibacterial effects of herbal extracts and antibiotics on methicillin-resistant Staphylococcus aureus: A computational and experimental study.
[So] Source:Exp Biol Med (Maywood);242(7):731-743, 2017 Apr.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Antibiotic resistance has become a serious global concern, and the discovery of antimicrobial herbal constituents may provide valuable solutions to overcome the problem. In this study, the effects of therapies combining antibiotics and four medicinal herbs on methicillin-resistant Staphylococcus aureus (MRSA) were investigated. Specifically, the synergistic effects of Magnolia officinalis, Verbena officinalis, Momordica charantia, and Daphne genkwa in combination with oxacillin or gentamicin against methicillin-resistant (ATCC43300) and methicillin-susceptible (ATCC25923) S. aureus were examined. In vitro susceptibility and synergistic testing were performed to measure the minimum inhibitory concentration and fractional inhibitory concentration (FIC) index of the antibiotics and medicinal herbs against MRSA and methicillin-susceptible S. aureus. To identify the active constituents in producing these synergistic effects, in silico molecular docking was used to investigate the binding affinities of 139 constituents of the four herbs to the two common MRSA inhibitory targets, penicillin binding proteins 2a (PBP2a) and 4 (PBP4). The physicochemical and absorption, distribution, metabolism, and excretion properties and drug safety profiles of these compounds were also analyzed. D. genkwa extract potentiated the antibacterial effects of oxacillin against MRSA, as indicated by an FIC index value of 0.375. M. officinalis and V. officinalis produced partial synergistic effects when combined with oxacillin, whereas M. charantia was found to have no beneficial effects in inhibiting MRSA. Overall, tiliroside, pinoresinol, magnatriol B, and momorcharaside B were predicted to be PBP2a or PBP4 inhibitors with good drug-like properties. This study identifies compounds that deserve further investigation with the aim of developing therapeutic agents to modulate the effect of antibiotics on MRSA. Impact statement Antibiotic resistant is a well-known threat to global health and methicillin-resistant Staphylococcus aureus is one of the most significant ones. These resistant bacteria kill thousands of people every year and therefore a new effective antimicrobial treatment is necessary. This study identified the herbs and their associated bioactive ingredients that can potential the effects of current antibiotics. These herbs have long history of human usage in China and have well-defined monograph in the Chinese Pharmacopeia. These indicate their relatively high clinical safety and may have a quicker drug development process than that of a new novel antibiotic. Based on the results of this study, the authors will perform further in vitro and animal studies, aiming to accumulate significant data for the application of clinical trial.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Daphne
Gentamicinas/farmacologia
Magnolia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Momordica charantia
Oxacilina/farmacologia
Extratos Vegetais/farmacologia
Verbena
[Mh] Termos MeSH secundário: Daphne/química
Sinergismo Farmacológico
Quimioterapia Combinada
Magnolia/química
Testes de Sensibilidade Microbiana
Simulação de Acoplamento Molecular
Momordica charantia/química
Staphylococcus aureus/efeitos dos fármacos
Verbena/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gentamicins); 0 (Plant Extracts); UH95VD7V76 (Oxacillin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216689828


  3 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27792456
[Au] Autor:Elshafie HS; Sakr S; Mang SM; Belviso S; De Feo V; Camele I
[Ad] Endereço:1 School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata , Potenza, Italy .
[Ti] Título:Antimicrobial Activity and Chemical Composition of Three Essential Oils Extracted from Mediterranean Aromatic Plants.
[So] Source:J Med Food;19(11):1096-1103, 2016 Nov.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is a growing interest in essential oils (EOs) as possible alternatives for traditional chemical pesticides. This study was carried out to characterize the chemical composition of the three EOs extracted from Verbena officinalis, Majorana hortensis, and Salvia officinalis using gas chromatography (GC) and GC-mass spectrometry (GC-MS) and to evaluate in vitro their efficacy against some phyto or human pathogens. The antifungal activity was investigated against Colletotrichum acutatum and Botrytis cinerea in comparison with Azoxystrobin as a large spectrum fungicide. Antibacterial activity was evaluated against Bacillus megaterium, Bacillus mojavensis, and Clavibacter michiganensis (G+ve) and Escherichia coli, Xanthomonas campestris, Pseudomonas savastanoi, and P. syringae pv. phaseolicola (G-ve) compared to a synthetic antibiotic tetracycline. Minimum inhibitory concentration was evaluated against the above tested fungi using 96-well microplate method. Results showed that the chemical structure of the three studied EOs was mainly composed of monoterpene compounds and all oils belong to the chemotype carvacrol/thymol. Results of GC analysis identified 64 compounds, which were identified based on their mass to charge ratio. Furthermore, the different concentrations of studied EOs inhibited the growth of tested microorganism in a dose-dependent manner.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Óleos Vegetais/química
Óleos Vegetais/farmacologia
Plantas/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Anti-Infecciosos/isolamento & purificação
Antifúngicos/química
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Bactérias/efeitos dos fármacos
Bactérias/isolamento & purificação
Relação Dose-Resposta a Droga
Microbiologia de Alimentos
Fungos/efeitos dos fármacos
Fungos/isolamento & purificação
Região do Mediterrâneo
Testes de Sensibilidade Microbiana
Óleos Voláteis/isolamento & purificação
Origanum/química
Salvia officinalis/química
Verbena/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Antifungal Agents); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


  4 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo SciELO Brasil
[PMID]:26871971
[Au] Autor:Xu Y; Xu Y; Luan H; Jiang Y; Tian X; Zhang S
[Ad] Endereço:School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, China.
[Ti] Título:Cardioprotection against experimental myocardial ischemic injury using cornin.
[So] Source:Braz J Med Biol Res;49(2):e5039, 2016 Feb.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Phosphorylated-cyclic adenosine monophosphate response element-binding protein (Phospho-CREB) has an important role in the pathogenesis of myocardial ischemia. We isolated the iridoid glycoside cornin from the fruit of Verbena officinalis L, investigated its effects against myocardial ischemia and reperfusion (I/R) injury in vivo, and elucidated its potential mechanism in vitro. Effects of cornin on cell viability, as well as expression of phospho-CREB and phospho-Akt in hypoxic H9c2 cells in vitro, and myocardial I/R injury in vivo, were investigated. Cornin attenuated hypoxia-induced cytotoxicity significantly in H9c2 cells in a concentration-dependent manner. Treatment of H9c2 cells with cornin (10 µM) blocked the reduction of expression of phospho-CREB and phospho-Akt in a hypoxic condition. Treatment of rats with cornin (30 mg/kg, iv) protected them from myocardial I/R injury as indicated by a decrease in infarct volume, improvement in hemodynamics, and reduction of severity of myocardial damage. Cornin treatment also attenuated the reduction of expression of phospho-CREB and phospho-Akt in ischemic myocardial tissue. These data suggest that cornin exerts protective effects due to an increase in expression of phospho-CREB and phospho-Akt.
[Mh] Termos MeSH primário: Proteína de Ligação a CREB/metabolismo
Frutas/química
Glicosídeos Iridoides/farmacologia
Isquemia Miocárdica/tratamento farmacológico
Fitoterapia
Substâncias Protetoras/farmacologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Verbena/química
[Mh] Termos MeSH secundário: Animais
Western Blotting
Proteína de Ligação a CREB/efeitos dos fármacos
Linhagem Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Creatina Quinase/sangue
Modelos Animais de Doenças
Hipóxia/tratamento farmacológico
Glicosídeos Iridoides/isolamento & purificação
Masculino
Extratos Vegetais/química
Proteínas Proto-Oncogênicas c-akt/efeitos dos fármacos
Ratos Sprague-Dawley
Troponina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Iridoid Glycosides); 0 (Plant Extracts); 0 (Protective Agents); 0 (Troponin); 548-37-8 (cornin iridoid); EC 2.3.1.48 (CREB-Binding Protein); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.3.2 (Creatine Kinase)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160213
[St] Status:MEDLINE


  5 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26824082
[Au] Autor:Grawish ME; Anees MM; Elsabaa HM; Abdel-Raziq MS; Zedan W
[Ti] Título:Short-term effects of Verbena officinalis Linn decoction on patients suffering from chronic generalized gingivitis: Double-blind randomized controlled multicenter clinical trial.
[So] Source:Quintessence Int;47(6):491-8, 2016.
[Is] ISSN:1936-7163
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the clinical efficacy of Verbena officinalis Linn decoction for patients with chronic generalized gingivitis in a double-blind randomized controlled multicenter clinical trial. METHOD AND MATERIALS: The patients in the test group and the control group were instructed to brush and floss. Additionally, the patients in the test group were asked to rinse their mouths with a V officinalis L decoction. The primary clinical outcome was the Gingival Index (GI). The GI and Plaque Index (PI) were measured at baseline (day 0), day 14, and day 28. RESULTS: Two hundred and sixty patients participated (control group = 130, and test group = 130). The clinical features of both the test and control groups were improved progressively throughout the time durations of day 0, day 14, and day 28 represented by highly significant decreases in both GI and PI (P < .001). The Mann-Whitney test revealed significant differences between the control and test groups for GI and PI at the 14-day examination and the 28-day examination (P < .001). At the beginning of the clinical trial, nonsignificant clinical differences were found following the statistical analyses of both GI (P = .981) and PI (P = .920) between the test and control groups. CONCLUSIONS: The tested V officinalis L decoction demonstrated efficacy in reducing tested indices and thus has a promising ameliorative effect for treating patients with chronic generalized gingivitis. CLINICAL SIGNIFICANCE: V officinalis L decoction has good clinical results with no adverse effects.
[Mh] Termos MeSH primário: Gengivite/tratamento farmacológico
Antissépticos Bucais
Verbena
[Mh] Termos MeSH secundário: Adulto
Doença Crônica
Índice de Placa Dentária
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Índice Periodontal
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Mouthwashes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE
[do] DOI:10.3290/j.qi.a35521


  6 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26276673
[Au] Autor:Xu Y; Zhang G; Kang Z; Xu Y; Jiang W; Zhang S
[Ad] Endereço:School of Pharmaceutical Sciences, Binzhou Medical University, No 346, Guanhai Road, Laishan District, Yantai, 264003, People's Republic of China.
[Ti] Título:Cornin increases angiogenesis and improves functional recovery after stroke via the Ang1/Tie2 axis and the Wnt/ß-catenin pathway.
[So] Source:Arch Pharm Res;39(1):133-42, 2016 Jan.
[Is] ISSN:0253-6269
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:We investigated whether cornin, an iridoid glycoside isolated from fruits of Verbena officinalis L., regulated angiogenesis and thereby improved functional outcomes after stroke and discovered a potential mechanism. The effects of cornin on proliferation of rat artery smooth muscle cell (RASMC) and signalling was investigated in vitro. Adult male rats were subjected to 1 h of middle cerebral artery occlusion (MCAO) and reperfusion and treated with or without 25 mg/kg of cornin, starting 24 h after ischemia and reperfusion, by continuous intravenous injection daily for 14 days. Neurological functional tests were performed and cerebral Evans blue extravasation was measured. Angiogenesis and angiogenic factor expressions were measured by immunohistochemistry and Western blotting, respectively. Cornin increased the proliferation of RASMC and enhanced the expression of Wnt5a, ß-catenin, cyclin D1 and angiopoietin-1 (Ang1). Cornin treatment promoted angiogenesis in the ischemic brain core and improved functional outcomes after stroke. Cornin-treated MCAO rats showed significant increase in vascularization and expression of vascular endothelial growth factor and Ang1 and phosphorylation of Tie2 and Akt compared with vehicle-treated MCAO rats. The Ang1/Tie2 axis and Wnt/ß-catenin pathways appear to mediate cornin-induced angiogenesis.
[Mh] Termos MeSH primário: Angiopoietina-1/metabolismo
Glicosídeos Iridoides/farmacologia
Receptor TIE-2/metabolismo
Recuperação de Função Fisiológica/efeitos dos fármacos
Acidente Vascular Cerebral/metabolismo
Via de Sinalização Wnt/efeitos dos fármacos
beta Catenina/metabolismo
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/fisiologia
Células Cultivadas
Glicosídeos Iridoides/isolamento & purificação
Glicosídeos Iridoides/uso terapêutico
Masculino
Neovascularização Fisiológica/efeitos dos fármacos
Neovascularização Fisiológica/fisiologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Ratos
Ratos Sprague-Dawley
Recuperação de Função Fisiológica/fisiologia
Acidente Vascular Cerebral/tratamento farmacológico
Verbena
Via de Sinalização Wnt/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Angiopoietin-1); 0 (Iridoid Glycosides); 0 (Plant Extracts); 0 (beta Catenin); 548-37-8 (cornin iridoid); EC 2.7.10.1 (Receptor, TIE-2)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150816
[St] Status:MEDLINE
[do] DOI:10.1007/s12272-015-0652-1


  7 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25617561
[Au] Autor:Mauriz E; Vallejo D; Tuñón MJ; Rodriguez-López JM; Rodríguez-Pérez R; Sanz-Gómez J; García-Fernández Mdel C
[Ad] Endereço:Institute of Food Science and Technology (ICTAL), University of León. State Reference Centre (CRE) of Disability and Dependency, San Andrés del Rabanedo, León.. elba.mauriz@unileon.es.
[Ti] Título:Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients.
[So] Source:Nutr Hosp;31(2):764-71, 2014 Nov 04.
[Is] ISSN:1699-5198
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Inflammation is one of the main contributory factors to the etiopathogenesis of multiple sclerosis (MS). Dietary interventions with Lipia citriadora (lemon verbena) extracts have been proved to be effective in the prevention of inflammatory diseases. OBJECTIVES: The aim of this study is to evaluate the effect of lemon verbena supplementation in pro- and anti- inflammatory serum biomarkers of patients with different clinical subtypes of multiple sclerosis. METHODS: The effect of lemon verbena supplementation (10% w/w verbascoside) was evaluated in a randomized, double-blinded placebo-controlled study with 30 participants classified in relapsing-remitting (n=10), primary progressive (n=5) and secondary progressive (n=15) MS presentations. Serum cytokine and C reactive protein levels were assessed in intervention and control groups for each MS clinical subtype after 28 days of dietary supplementation. RESULTS: Serum levels of C reactive protein and 8 cytokines/ inflammatory (IFN-γ, IL-12, IL-23, IL-6, TNF-α, TGF-ß, IL-4 and IL-10) markers were studied. Secondary progressive MS- supplemented patients showed C reactive protein concentrations significantly lower compared to the placebo group (p.
[Mh] Termos MeSH primário: Citocinas/sangue
Esclerose Múltipla/sangue
Extratos Vegetais/farmacologia
Verbena/química
[Mh] Termos MeSH secundário: Adulto
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Biomarcadores/sangue
Suplementos Nutricionais
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biomarkers); 0 (Cytokines); 0 (Plant Extracts)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150125
[St] Status:MEDLINE
[do] DOI:10.3305/nh.2015.31.2.8319


  8 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25045888
[Au] Autor:Shu J; Chou G; Wang Z
[Ad] Endereço:The MOE Key Laboratory for Standardization of Chinese Medicines and SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Zhangjiang, Shanghai 201203, China. shujc210@163.com.
[Ti] Título:Two new iridoids from Verbena officinalis L.
[So] Source:Molecules;19(7):10473-9, 2014 Jul 18.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Two new iridoids, 3-(5-(methoxycarbonyl)-2-oxo-2H-pyran-3-yl)butanoic acid, named verbeofflin I (1), and 7-hydroxydehydrohastatoside (2), were isolated from the aerial part of Verbena officinalis L, along with three known iridoids, verbenalin (3), 3,4-dihydroverbenalin (4), hastatoside (5) by means of various column chromatography steps. The structures of these compounds were elucidated through analysis of their spectroscopic data obtained using 1D and 2D NMR and MS techniques. Verbeofflin I (1) is the new class of secoiridoid in the family Verbenaceae.
[Mh] Termos MeSH primário: Iridoides/química
Iridoides/isolamento & purificação
Verbena/química
[Mh] Termos MeSH secundário: Cromatografia Líquida
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Iridoids)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140722
[Lr] Data última revisão:
140722
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140722
[St] Status:MEDLINE
[do] DOI:10.3390/molecules190710473


  9 / 62 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24513110
[Au] Autor:Felgines C; Fraisse D; Besson C; Vasson MP; Texier O
[Ad] Endereço:Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Equipe ECREIN, Laboratoire de Pharmacognosie et Phytothérapie, 28 Place Henri-Dunant, BP 38, F-63001 Clermont-Ferrand Cedex 1, France.
[Ti] Título:Bioavailability of lemon verbena (Aloysia triphylla) polyphenols in rats: impact of colonic inflammation.
[So] Source:Br J Nutr;111(10):1773-81, 2014 May 28.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lemon verbena (Aloysia triphylla) infusion, a widely consumed herbal tea, contains significant amounts of polyphenols such as flavone diglucuronides and phenylpropanoid glycosides (mainly verbascoside). We have recently shown that lemon verbena infusion offers beneficial effects against dextran sodium sulphate (DSS)-induced colonic inflammation in rats. The present study aimed to evaluate the bioavailability and intestinal absorption of polyphenols derived from lemon verbena infusion in both healthy and colitic rats. For this purpose, lemon verbena infusion was given to rats ad libitum for 14 d, and then 4 % DSS was added to the infusion for 7 d. Before and after DSS administration, 24 h urinary excretion of polyphenols was determined. Flavones were excreted in the urine as conjugated aglycones, and their excretion was not significantly altered by colonic inflammation. Only trace amounts of verbascoside were excreted in the urine, but various metabolites (hydroxycinnamic acids) were detected. The urinary excretion of hydroxycinnamic acids, particularly that of caffeic acid, increased after DSS administration (P< 0·05). Only flavone aglycones (luteolin and diosmetin) were excreted in the faeces in small proportions (3·2 % of ingested flavones). Intestinal absorption of lemon verbena polyphenols was examined using an in situ intestinal perfusion model. Intestinal absorption of verbascoside and flavone diglucuronides did not significantly differ between the healthy and colitic rats. Collectively, these results show that intestinal absorption and urinary excretion of lemon verbena flavone diglucuronides were not altered by colonic inflammation, but that urinary excretion of hydroxycinnamic acids derived from verbascoside was affected in a colitic situation.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Colo/metabolismo
Doenças Inflamatórias Intestinais/metabolismo
Absorção Intestinal/fisiologia
Polifenóis/farmacocinética
Verbena/metabolismo
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Bebidas
Disponibilidade Biológica
Cromatografia Líquida de Alta Pressão
Sulfato de Dextrana
Modelos Animais de Doenças
Fezes/química
Doenças Inflamatórias Intestinais/induzido quimicamente
Masculino
Polifenóis/urina
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Polyphenols); 9042-14-2 (Dextran Sulfate)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:140414
[Lr] Data última revisão:
140414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140212
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114514000026


  10 / 62 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
[PMID]:24146482
[Au] Autor:Kou WZ; Yang J; Yang QH; Wang Y; Wang ZF; Xu SL; Liu J
[Ad] Endereço:Department of Oncology, First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
[Ti] Título:Study on in-vivo anti-tumor activity of Verbena officinalis extract.
[So] Source:Afr J Tradit Complement Altern Med;10(3):512-7, 2013.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:We investigated the anti-tumor effects of Verbena officinalis extract on H22 tumor-bearing mice and its effect on immune function. Mice model of H22 solid tumor was established, the mice were divided into five groups and administered the extract, later, tumors were removed and inhibition rates were calculated; spleens were removed and spleen indices were calculated, and the sheep red blood cell-delayed-type hypersensitivity (SRBC-DTH) and the serum hemolysin level were determined. The Verbena officinalis extract had anti-tumor effect, with the inhibition rate reaching 38.78%, it also increased the spleen index to a certain extent, in addition, the changes in DTA and HA were not obvious compared with the model group. The Verbena officinalis extract had in vivo anti-tumor effect, while causing no damage on the immune function.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Neoplasias/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Verbena
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/efeitos adversos
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Modelos Animais de Doenças
Feminino
Masculino
Camundongos
Camundongos Endogâmicos
Neoplasias/sangue
Extratos Vegetais/efeitos adversos
Extratos Vegetais/farmacologia
Ovinos
Baço/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131023
[St] Status:MEDLINE



página 1 de 7 ir para página                  
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde