Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.595.200 [Categoria DeCS]
Referências encontradas : 30 [refinar]
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[PMID]:28223131
[Au] Autor:Chen H; Ouyang K; Jiang Y; Yang Z; Hu W; Xiong L; Wang N; Liu X; Wang W
[Ad] Endereço:Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
[Ti] Título:Constituent analysis of the ethanol extracts of Chimonanthus nitens Oliv. leaves and their inhibitory effect on α-glucosidase activity.
[So] Source:Int J Biol Macromol;98:829-836, 2017 May.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The ethanol extracts of Chimonanthus nitens Oliv. leaves were prepared sequentially by ethanol gradient elution and tested for their α-glucosidase inhibitory. The fraction of 50% ethanol eluate (EE) exhibited the notable inhibition with IC of 0.376mg/mL. Also, 50% EE was chemically characterized by liquid chromatography-mass spectrometry (LC-MS) analysis. Eight compounds including rutin (1), hyperin (2), isoquercitrin (3), luteoloside (4), astragalin (6), quercetin (13), naringenin (14), kaempferol (15) were identified by compared with standard substances as well as proper luteolin-5-O-glucoside (5), kaempferol-7-O-rhamnoside (9), 5,7,8-trihydroxy-2-methoxyl-flavone-7-O-glucoside (10), kaempferol-7-O-acetyl-galactoside (11). The experiments of ultra-filtration combined with liquid chromatography-mass spectrometry (UF-LC-MS) guided quercetin and kaempferol as the key factors for 50% EE showing highly inhibitory activity on α-glucosidase. Quercetin and kaempferol inhibited yeast α-glucosidase in a mixed-type manner with IC of 66.8 and 109µg/mL, respectively. These results would provide theoretical underpinning for the C. nitens Oliv. leaves ethanol extracts used as nutraceutical health supplement in the management of type 2 diabetes.
[Mh] Termos MeSH primário: Calycanthaceae/química
Extratos Vegetais/farmacologia
Quercetina/farmacologia
alfa-Glucosidases/biossíntese
[Mh] Termos MeSH secundário: Diabetes Mellitus Tipo 2/dietoterapia
Etanol/química
Inibidores de Glicosídeo Hidrolases/química
Inibidores de Glicosídeo Hidrolases/farmacologia
Seres Humanos
Quempferóis/química
Quempferóis/isolamento & purificação
Quempferóis/farmacologia
Extratos Vegetais/química
Folhas de Planta/química
Quercetina/química
Quercetina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycoside Hydrolase Inhibitors); 0 (Kaempferols); 0 (Plant Extracts); 3K9958V90M (Ethanol); 731P2LE49E (kaempferol); 9IKM0I5T1E (Quercetin); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


  2 / 30 MEDLINE  
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[PMID]:27706658
[Au] Autor:Zhou B; Liu SZ; Li MJ; Chen ZH; Wang P; Cheng D
[Ad] Endereço:School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China tju_zhoubin@163.com.
[Ti] Título:Study on quality standards for Chimonanthus nitens.
[So] Source:Genet Mol Res;15(3), 2016 Aug 29.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Chimonanthus nitens Oliv. is a commonly used traditional Chinese medicine. Terpenoids, flavonoids, and coumarins are usually considered its main bioactive ingredients. Thus, qualitative and quantitative analyses of these compounds are crucial in quality control studies of Chimonanthus nitens. In this study, five compounds were identified by double-development thin layer chromatography (TLC) and the content of four compounds was determined by high performance liquid chromatography; the detection wavelength was set to 344 nm and the column temperature was 40°C. All calibration curves showed good linear regression (R2 > 0.9995). The average recoveries ranged from 97.06 to 104.44%. The RSD was below 4.2%. Four compounds remained stable over 24 h and the relative standard deviation (RSD) of the precision of their measurement was less than 1.5%. The developed method was reproducible, sensitive, and simple, and could be used for quality control of Chimonanthus nitens.
[Mh] Termos MeSH primário: Calycanthaceae/química
Cumarínicos/isolamento & purificação
Medicamentos de Ervas Chinesas
Rutina/isolamento & purificação
Escopoletina/isolamento & purificação
[Mh] Termos MeSH secundário: Calibragem
Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Seres Humanos
Medicina Tradicional Chinesa
Extratos Vegetais/química
Controle de Qualidade
Padrões de Referência
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Drugs, Chinese Herbal); 0 (Plant Extracts); 304915F056 (isofraxidin); 5G06TVY3R7 (Rutin); H5841PDT4Y (scoparone); KLF1HS0SXJ (Scopoletin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15038984


  3 / 30 MEDLINE  
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[PMID]:27527132
[Au] Autor:Li H; Zhang Y; Liu Q; Sun C; Li J; Yang P; Wang X
[Ad] Endereço:College of Pharmacy, Shandong University of Traditional Chinese Medicine, 4655 Daxue Street, Jinan 250355, Shandong, China. huaizhili123@sina.com.
[Ti] Título:Preparative Separation of Phenolic Compounds from Chimonanthus praecox Flowers by High-Speed Counter-Current Chromatography Using a Stepwise Elution Mode.
[So] Source:Molecules;21(8), 2016 Aug 04.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:High-speed counter-current chromatography (HSCCC) has been successfully used for the separation of eight compounds from Chimonanthus praecox flowers. Firstly, the crude extract of Chimonanthus praecox flowers was dissolved in a two-phase solvent system composed of petroleum ether-ethyl acetate-methanol-H2O (5:5:3:7, v/v) and divided into two parts: the upper phase (part I) and the lower phase (part II). Then, HSCCC was applied to separate the phenolic acids from part I and part II, respectively. Considering the broad polarity range of target compounds in part I, a stepwise elution mode was established. Two optimal solvent systems of petroleum ether-ethyl acetate-methanol-H2O-formic acid (FA) (5:5:3:7:0.02, 5:5:4.3:5.7:0.02, v/v) were employed in this separation. Five phenylpropanoids and two flavonoids were successfully separated from 280 mg of part I, including 8.7 mg of 3,4-dihydroxy benzoic acid (a, 95.3% purity), 10.9 mg of protocatechualdehyde (b, 96.8% purity), 11.3 mg of p-coumaric acid (c, 98.9% purity), 12.2 mg of p-hydroxybenzaldehyde (d, 95.9% purity), 24.7 mg of quercetin (e, 97.3% purity), 33.8 mg of kaempferol (f, 96.8% purity), and 24.6 mg of 4-hydroxylcinnamic aldehyde (g, 98.0% purity). From 300 mg of part II, 65.7 mg of rutin (h, 98.2% purity), 7.5 mg of 3,4-dihydroxy benzoic acid (a, 77.4% purity), and 4.7 mg of protocatechualdehyde (b, 81.6% purity) were obtained using the solvent system EtOAc-n-butanol (n-BuOH)-FA-H2O (4:1:0.5:5, v/v). The structures of the eight pure compounds were confirmed by electrospray ionization-mass spectrometry (ESI-MS), ¹H-NMR and (13)C-NMR. To the best of our knowledge, compounds a-d and f were the first separated and reported from the Chimonanthus praecox flower extract.
[Mh] Termos MeSH primário: Calycanthaceae/química
Flores/química
Fenóis/química
Fenóis/isolamento & purificação
[Mh] Termos MeSH secundário: Cromatografia Líquida
Distribuição Contracorrente
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Espectroscopia de Prótons por Ressonância Magnética
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160817
[St] Status:MEDLINE


  4 / 30 MEDLINE  
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[PMID]:26790964
[Au] Autor:Li D; Jiang YY; Jin ZM; Li HY; Xie HJ; Wu B; Wang KW
[Ad] Endereço:Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310018, PR China.
[Ti] Título:Isolation and absolute configurations of diastereomers of 8α-hydroxy-T-muurolol and (1α,6ß,7ß)-cadinane-4-en-8α,10α-diol from Chimonanthus salicifolius.
[So] Source:Phytochemistry;122:294-300, 2016 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the aerial parts of Chimonanthus salicifolius resulted in the isolation of two sesquiterpenoids, 8α-hydroxy-T-muurolol and (1α,6ß,7ß)-cadinane-4-en-8α,10α-diol, together with 13 known compounds. The 15 structures were established by means of 1D and 2D NMR spectroscopy. The relative and absolute configurations of 8α-hydroxy-T-muurolol and 8α,11-elemodiol were achieved by NOESY experiments and X-ray crystallography using CuKα radiation. 8α-hydroxy-T-muurolol and (1α,6ß,7ß)-cadinane-4-en-8α,10α-diol showed immunosuppressive activities in a dose-dependent manner.
[Mh] Termos MeSH primário: Calycanthaceae/química
Sesquiterpenos/química
Terpenos/química
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Ressonância Magnética Nuclear Biomolecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Sesquiterpenes); 0 (T-muurolol); 0 (Terpenes); 0 (cadinane)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160122
[St] Status:MEDLINE


  5 / 30 MEDLINE  
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[PMID]:26503546
[Au] Autor:Numan RW; Ackermann SS; Shelgren JS
[Ad] Endereço:a Vetora Te Awamutu , 565 Mahoe Street, Te Awamutu , New Zealand.
[Ti] Título:Wintersweet (Chimonanthus praecox) toxicity in four goats.
[So] Source:N Z Vet J;64(3):179-81, 2016 May.
[Is] ISSN:0048-0169
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CASE HISTORY: A one-year-old female goat presented with acute onset of recumbency, seizures and vocalisation approximately 5 hours after being given access to branch trimmings from a neighbour's garden. The plant from which the pruned branches came was subsequently identified as wintersweet (Chimonanthus praecox). Three other goats kept in the same paddock displayed similar clinical signs over a period of 4 hours following the initial presentation. CLINICAL FINDINGS: All four goats were ataxic, displayed tetanic seizures and were in lateral recumbency; they had dilated pupils and were hyperaesthetic, with elevated heart and respiratory rates. After symptomatic treatment, including sedation with diazepam, one of the three goats continued to deteriorate and was subjected to euthanasia. The remaining three goats recovered over 1-14 days with nursing care and physiotherapy. DIAGNOSIS: Toxicity due to ingestion of wintersweet, which contains the alkaloid calycanthine. CLINICAL RELEVANCE: Calycanthine is a central nervous system toxin, causing convulsions. Wintersweet shrubs are present in many New Zealand gardens. Practitioners should be aware that the seeds and flowers, and possibly the leaves, of this plant are highly toxic with signs of toxicity including ataxia, hyperaesthesia and seizures.
[Mh] Termos MeSH primário: Calycanthaceae/toxicidade
Doenças das Cabras/induzido quimicamente
Naftiridinas/toxicidade
Intoxicação por Plantas/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças do Sistema Nervoso Central/induzido quimicamente
Doenças do Sistema Nervoso Central/veterinária
Feminino
Cabras
Masculino
Naftiridinas/química
Intoxicação por Plantas/etiologia
Plantas Tóxicas/química
Plantas Tóxicas/toxicidade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Naphthyridines); F62N8QPR7V (calycanthine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151028
[St] Status:MEDLINE
[do] DOI:10.1080/00480169.2015.1111779


  6 / 30 MEDLINE  
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[PMID]:27071249
[Au] Autor:Wang XH; Liu X; Gao BW; Zhang ZX; Shi SP; Tu PF
[Ti] Título:[Cloning and expression analysis of glucose-6-phosphate dehydrogenase 1 (G6PDH1) gene from Chimonanthus praecox].
[So] Source:Zhongguo Zhong Yao Za Zhi;40(21):4160-4, 2015 Nov.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Glucose-6-phosphate dehydrogenase is main regulatory enzyme for pentose phosphate pathway. To amplify the core sequence of G6PDH gene from Chimonanthus praecox, the primers were synthesized, based on the conserved nucleotide sequence of other reported plant G6PDH genes. The specific primers were designed according to the major fragment. The full length cDNA of the G6PDH1 gene was isolated by the 3' and 5' rapid amplification of cDNA ends approach. Transcript levels of G6PDH1 isoform was measured by real-time quantitative RT-PCR in different tissues and in responds to cold treatment. The G6PDH1 subcellular localization, transmembrane domain, three-dimensional structure, and phylogenetic analysis were predicted by different software to analysis the bioinformatics of G6PDH1 protein. The G6PDH1 cDNA sequence was 2 011 bp in length and consisted of 1 551 bp Open Reading Frame (ORF) , encoding a protein of 516 amino acids. Expression analysis results in different tissues showed that G6PDH1 was primarily observed in flowers and roots, as opposed to the leaves and stems. Cold treatment experiments indicated that cold treatment caused a rapid increase in G6PDH1 expression in flowers within 12 h. The full-length cDNA of G6PDH1 and its expression analysis will play an important role for further study on cold stress responses in Ch. praecox.
[Mh] Termos MeSH primário: Calycanthaceae/enzimologia
Clonagem Molecular
Glucosefosfato Desidrogenase/genética
Proteínas de Plantas/genética
[Mh] Termos MeSH secundário: Calycanthaceae/química
Calycanthaceae/classificação
Calycanthaceae/genética
Estabilidade Enzimática
Glucosefosfato Desidrogenase/química
Glucosefosfato Desidrogenase/metabolismo
Modelos Moleculares
Fases de Leitura Aberta
Filogenia
Proteínas de Plantas/química
Proteínas de Plantas/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Proteins); EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160413
[Lr] Data última revisão:
160413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160414
[St] Status:MEDLINE


  7 / 30 MEDLINE  
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[PMID]:25884552
[Au] Autor:Xu JB; Cheng KJ
[Ad] Endereço:Chemical Biology Center, Lishui Institute of Agricultural Sciences, 827 Liyang Street, Lishui 323000, Zhejiang, China. xujinbiao2015@126.com.
[Ti] Título:Studies on the alkaloids of the calycanthaceae and their syntheses.
[So] Source:Molecules;20(4):6715-38, 2015 Apr 15.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Plants of the Calycanthaceae family, which possesses four genera and about 15 species, are mainly distributed in China, North America and Australia. Chemical studies on the Calycanthaceae have led to the discovery of about 14 alkaloids of different skeletons, including dimeric piperidinoquinoline, dimeric pyrrolidinoindoline and/or trimeric pyrrolidinoindolines, which exhibit significant anti-convulsant, anti-fungal, anti-viral analgesic, anti-tumor, and anti-melanogenesis activities. As some of complex tryptamine-derived alkaloids exhibit promising biological activities, the syntheses of these alkaloids have also been a topic of interest in synthetic chemistry during the last decades. This review will focus on the structures and total syntheses of these alkaloids.
[Mh] Termos MeSH primário: Alcaloides/biossíntese
Alcaloides/química
Calycanthaceae/química
Calycanthaceae/metabolismo
[Mh] Termos MeSH secundário: Vias Biossintéticas
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Alkaloids)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150418
[Lr] Data última revisão:
150418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150418
[St] Status:MEDLINE
[do] DOI:10.3390/molecules20046715


  8 / 30 MEDLINE  
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[PMID]:24668298
[Au] Autor:Morikawa T; Nakanishi Y; Ninomiya K; Matsuda H; Nakashima S; Miki H; Miyashita Y; Yoshikawa M; Hayakawa T; Muraoka O
[Ad] Endereço:Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
[Ti] Título:Dimeric pyrrolidinoindoline-type alkaloids with melanogenesis inhibitory activity in flower buds of Chimonanthus praecox.
[So] Source:J Nat Med;68(3):539-49, 2014 Jul.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A methanol extract of the flower buds of Chimonanthus praecox (L.) Link (Calycanthaceae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the extract, five dimeric pyrrolidinoindoline alkaloids and four sesquiterpenes were isolated, together with 16 known compounds. Among them, (-)-chimonanthine (1, IC50 = 0.93 µM), (-)-folicanthine (2, 1.4 µM), and (-)-calycanthidine (3, 1.8 µM) showed potent inhibitory effects without notable cytotoxicity at the effective concentrations. The most potent alkaloid (1) inhibited both tyrosinase and tyrosine-related protein-1 mRNA expressions, to which the melanogenesis inhibitory activity would be ascribable.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Calycanthaceae/química
Indóis/farmacologia
Melaninas/biossíntese
Pirróis/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Animais
Linhagem Celular Tumoral
Dimerização
Flores/química
Indóis/química
Camundongos
Monofenol Mono-Oxigenase/metabolismo
Pirróis/química
Sesquiterpenos/química
Sesquiterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Indoles); 0 (Melanins); 0 (Pyrroles); 0 (Sesquiterpenes); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140327
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-014-0832-1


  9 / 30 MEDLINE  
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[PMID]:24620687
[Au] Autor:Zhou B; Li MJ; Wang P; Cheng D; Li J; Cui XD
[Ti] Título:[Study on quality standard of Chimonanthus nitens leaf].
[So] Source:Zhong Yao Cai;36(9):1434-6, 2013 Sep.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To set up the quality standard of Chimonanthus nitens leaf. METHODS: Five compounds were identified by double-development thin layer chromatography, the plate was colorized with 1% vanillin-H2 SO4 solution and warmed up in 110 degrees C; The content of four compounds was determined by HPLC, the chromatography separation was performed on the Elite hypersil ODS2 (250 mm x 4.6 mm, 5 microm) column with gradient elution. The mixture of acetonitrile and water as the mobile phase at a flow rate of 1.0 mL/min was used, the detection wavelength was 344 nm and the column temperature was set at 40 degrees C. RESULTS: The TLC identification was highly specific and spots were clear. In HPLC method, the calibration curve was linear in the range of 5.665 - 56.65 microg/mL for scopoletin (r = 0.9999), the average recovery was 97.06% and RSD was 1.27%; The calibration curve was linear in the range of 2.4312 - 24.312 microg/mL for isofraxidin (r = 0.9999), the average recovery was 102.86% and RSD% was 0.93%; The calibration curve presented a linear range from 2.444 - 24.44 microg/mL for scoparone (r = 0.9999), the average recovery was 102.18% and RSD was 1.81%. The standard curve presented a linear range from 9.012 - 90.12 microg/mL for rutin (r = 0.9992), the average recovery was 104.44% and RSD was 4.2%. CONCLUSION: These methods are reproducible, sensitive and simple and can be used to control the quality of Chimonanthus nitens leaf.
[Mh] Termos MeSH primário: Calycanthaceae/química
Cromatografia Líquida de Alta Pressão/métodos
Cumarínicos/análise
Medicamentos de Ervas Chinesas/química
Escopoletina/análise
[Mh] Termos MeSH secundário: Cromatografia em Camada Delgada
Medicamentos de Ervas Chinesas/análise
Medicamentos de Ervas Chinesas/normas
Folhas de Planta/química
Controle de Qualidade
Reprodutibilidade dos Testes
Rutina/análise
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coumarins); 0 (Drugs, Chinese Herbal); 5G06TVY3R7 (Rutin); H5841PDT4Y (scoparone); KLF1HS0SXJ (Scopoletin)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:140313
[Lr] Data última revisão:
140313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140314
[St] Status:MEDLINE


  10 / 30 MEDLINE  
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[PMID]:24380302
[Au] Autor:Wu YF; Lv GY; Zhang ZR; Yu JJ; Yan MQ; Chen SH
[Ad] Endereço:Wenzhou Medical College, Wenzhou 325035, China. 472185629@qq.com
[Ti] Título:[The influence of storage time on content of volatile oil and cineole of Chimonanthus salicifolius].
[So] Source:Zhongguo Zhong Yao Za Zhi;38(17):2803-6, 2013 Sep.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The vapour distillation was used to extract the volatile oil of Chimonanthus salicifolius with different storage time, determine the content of cineole in volatile oil by GC, to study the influence of storage time on the content of volatile oil and cineole of C. salicifolius. We found that the content of volatile oil in fresh herbs of C. salicifolius was 0.023 0 mL x g(-1), it was decreased to 0.020 0, 0.017 5 mL x g(-1) respectively after storing for 4, 12 months; the GC methodological study of precision, stability and repeatability, RSD < 2%, the average recovery rate was 99.50%, RSD 1.7%; the content of cineole in fresh volatile oil was 54.30%, it was increased to about 62% and remained stably with the time. Therefore, the content of volatile oil and cineole of C. salicifolius can change with the storage time; GC method for the determination of the content of cineole is accurate, reliable, specific and repeatable, it's suitable as a quality control method of C. salicifolius.
[Mh] Termos MeSH primário: Calycanthaceae/química
Cicloexanóis/análise
Armazenamento de Medicamentos/métodos
Medicamentos de Ervas Chinesas/análise
Monoterpenos/análise
Óleos Voláteis/análise
Óleos Vegetais/análise
[Mh] Termos MeSH secundário: Cromatografia Gasosa
[Pt] Tipo de publicação:ENGLISH ABSTRACT; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclohexanols); 0 (Drugs, Chinese Herbal); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Oils); RV6J6604TK (eucalyptol)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:140101
[Lr] Data última revisão:
140101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140102
[St] Status:MEDLINE



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