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Pesquisa : B01.650.940.800.575.912.250.595.400.149.124 [Categoria DeCS]
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[PMID]:29413573
[Au] Autor:Cheng J; He S; Wan Q; Jing P
[Ad] Endereço:Research Center for Food Safety and Nutrition, Key Lab of Urban Agriculture (South), Bor S. Luh Food Safety Research Center, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
[Ti] Título:Multiple fingerprinting analyses in quality control of Cassiae Semen polysaccharides.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:22-27, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Quality control issue overshadows potential health benefits of Cassiae Semen due to the analytic limitations. In this study, multiple-fingerprint analysis integrated with several chemometrics was performed to assess the polysaccharide quality of Cassiae Semen harvested from different locations. FT-IR, HPLC, and GC fingerprints of polysaccharide extracts from the authentic source were established as standard profiles, applying to assess the quality of foreign sources. Analyses of FT-IR fingerprints of polysaccharide extracts using either Pearson correlation analysis or principal component analysis (PCA), or HPLC fingerprints of partially hydrolyzed polysaccharides with PCA, distinguished the foreign sources from the authentic source. However, HPLC or GC fingerprints of completely hydrolyzed polysaccharides couldn't identify all foreign sources and the methodology using GC is quite limited in determining the monosaccharide composition. This indicates that FT-IR/HPLC fingerprints of non/partially-hydrolyzed polysaccharides, respectively, accompanied by multiple chemometrics methods, might be potentially applied in detecting and differentiating sources of Cassiae Semen.
[Mh] Termos MeSH primário: Cinnamomum aromaticum/química
Polissacarídeos/análise
Polissacarídeos/química
Sementes/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa
Cromatografia Líquida de Alta Pressão
Análise de Componente Principal
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polysaccharides)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:28886578
[Au] Autor:Kim JH
[Ad] Endereço:Division of Pharmacology, School of Korean Medicine, Pusan National University,50612, Republic of Korea. Electronic address: kmsct@pusan.ac.kr.
[Ti] Título:Extraction time and temperature affect the extraction efficiencies of coumarin and phenylpropanoids from Cinnamomum cassia bark using a microwave-assisted extraction method.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:196-203, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Microwave-assisted extraction (MAE), an efficient extraction tool, was employed to extract a coumarin and five phenylpropanoids (cinnamic acid, cinnamyl alcohol, cinnamaldehyde, 2-hydroxycinnamadehyde, and 2-methoxycinnamaldehyde) from Cinnamomum cassia bark using water as the extraction solvent. Six marker compounds were quantified by high-performance liquid chromatography-diode array detector using a validated analytical method. To investigate the influences of temperature and time on the extraction yields of the six marker compounds, the water extracts of C. cassia bark were prepared using a MAE method at six different extraction temperatures (70, 75, 80, 85, 90, and 95°C) and times (2, 4, 6, 8, 10, and 12min). Their influences were assessed by multiple regression analysis. The results obtained demonstrated that higher extraction temperature and longer extraction time positively affected coumarin and cinnamyl alcohol contents, but negatively affected extract contents of cinnamic acid, cinnamaldehyde and 2-hydroxycinnamaldehyde (all p-<0.05). The extraction of 2-methoxycinnamaldehyde was affected by both positively and negatively by increasing temperature and time. These changes during MAE were assumed by the chemical natures of the marker compounds with various functional groups. In conclusion, temperature and times significantly affected the extraction efficiencies of a coumarin and five phenylpropanoids from C. cassia bark when a water-based MAE method was used. This study provides a novel approach to the preparation of the water extract of C. cassia bark using MAE.
[Mh] Termos MeSH primário: Fracionamento Químico/métodos
Cinamatos
Cinnamomum aromaticum/química
Cumarínicos/isolamento & purificação
Casca de Planta/química
[Mh] Termos MeSH secundário: Acroleína/análogos & derivados
Cromatografia Líquida de Alta Pressão/métodos
Cinamatos/análise
Cinamatos/química
Cinamatos/isolamento & purificação
Cumarínicos/análise
Cumarínicos/química
Modelos Lineares
Micro-Ondas
Extratos Vegetais/química
Propanóis
Análise de Regressão
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Coumarins); 0 (Plant Extracts); 0 (Propanols); 7864XYD3JJ (Acrolein); A4VZ22K1WT (coumarin); SR60A3XG0F (cinnamic aldehyde); SS8YOP444F (cinnamyl alcohol); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


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[PMID]:28682072
[Au] Autor:Shin SH; Lee SR; Lee E; Kim KH; Byun S
[Ad] Endereço:Program in Bioinformatics and Computational Biology, University of Minnesota , Minneapolis, Minnesota 55455, United States.
[Ti] Título:Caffeic Acid Phenethyl Ester from the Twigs of Cinnamomum cassia Inhibits Malignant Cell Transformation by Inducing c-Fos Degradation.
[So] Source:J Nat Prod;80(7):2124-2130, 2017 Jul 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The twigs of Cinnamomum cassia, commonly referred to as Cinnamomi Ramulus, are widely used as one of the primary ingredients in Chinese/Korean traditional medicines that have anticancer effects. However, the active constituents responsible for its anticancer effects and their molecular mechanisms still remain to be elucidated. Caffeic acid phenethyl ester (CAPE) and caffeic acid (CA) were isolated for the first time from C. cassia using LC-MS-guided phytochemical isolation methods. CAPE significantly suppressed EGF- and TPA-induced cell transformation of JB6 P+ cells at sub-micromolar concentrations, whereas CA, a structurally similar compound to CAPE, had no such effect. The antiproliferative and chemopreventive activity of CAPE was found to arise through the inhibition of AP-1 transcriptional activity via the promotion of c-Fos degradation. These findings demonstrate that CAPE may contribute to the chemopreventive/chemotherapeutic effects of C. cassia through downregulating c-Fos.
[Mh] Termos MeSH primário: Anticarcinógenos/isolamento & purificação
Anticarcinógenos/farmacologia
Ácidos Cafeicos/isolamento & purificação
Ácidos Cafeicos/farmacologia
Cinnamomum aromaticum/química
Álcool Feniletílico/análogos & derivados
Caules de Planta/química
Proteínas Proto-Oncogênicas c-fos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anticarcinógenos/química
Ácidos Cafeicos/química
Estrutura Molecular
Álcool Feniletílico/química
Álcool Feniletílico/isolamento & purificação
Álcool Feniletílico/farmacologia
Proteínas Proto-Oncogênicas c-fos/metabolismo
República da Coreia
Transdução de Sinais/efeitos dos fármacos
Fator de Transcrição AP-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 0 (Caffeic Acids); 0 (Proto-Oncogene Proteins c-fos); 0 (Transcription Factor AP-1); G960R9S5SK (caffeic acid phenethyl ester); ML9LGA7468 (Phenylethyl Alcohol); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00433


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[PMID]:28665598
[Au] Autor:Guoruoluo Y; Zhou H; Zhou J; Zhao H; Aisa HA; Yao G
[Ad] Endereço:Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi, Xinjiang 830011, People's Republic of China.
[Ti] Título:Isolation and Characterization of Sesquiterpenoids from Cassia Buds and Their Antimicrobial Activities.
[So] Source:J Agric Food Chem;65(28):5614-5619, 2017 Jul 19.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cassia buds, the immature fruits of Cinnamomum cassia (Lauraceae), are widely consumed as a food spice, dietary supplements, flavoring agents, and preservatives. In this study, cassia buds were phytochemically investigated for the first time, leading to the isolation of 2 new sesquiterpenoids (1 and 2) and 10 known sesquiterpenoids (3-12). Their structures were determined by spectrometric and spectroscopic analyses, including nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and circular dichroism. Cinnamosim A (1) represents the ninth example of the rare cyperane-type sesquiterpenoids. All of the compounds (1-12) isolated from cassia buds were evaluated for antimicrobial activities, with compounds 1-3, 5-8, 11, and 12 exhibiting strong antimicrobial activities against Candida albicans and compounds 6, 7, and 11 showing moderate antibacterial activities against Escherichia coli and Staphylococcus aureus. The present investigation indicated that sesquiterpenoids from cassia buds might be used as potential antimicrobial agents to preserve food.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Cinnamomum aromaticum/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Sesquiterpenos/química
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/isolamento & purificação
Candida albicans/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Estrutura Molecular
Extratos Vegetais/isolamento & purificação
Sesquiterpenos/isolamento & purificação
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts); 0 (Sesquiterpenes)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01294


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[PMID]:28428175
[Au] Autor:Rowell TR; Reeber SL; Lee SL; Harris RA; Nethery RC; Herring AH; Glish GL; Tarran R
[Ad] Endereço:Marsico Lung Institute, The University of North Carolina, Chapel Hill, North Carolina.
[Ti] Título:Flavored e-cigarette liquids reduce proliferation and viability in the CALU3 airway epithelial cell line.
[So] Source:Am J Physiol Lung Cell Mol Physiol;313(1):L52-L66, 2017 Jul 01.
[Is] ISSN:1522-1504
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:E-cigarettes are generally thought of as a safer smoking alternative to traditional cigarettes. However, little is known about the effects of e-cigarette liquids (e-liquids) on the lung. Since over 7,000 unique flavors have been identified for purchase in the United States, our goal was to conduct a screen that would test whether different flavored e-liquids exhibited different toxicant profiles. We tested the effects of 13 different flavored e-liquids [with nicotine and propylene glycol/vegetable glycerin (PG/VG) serving as controls] on a lung epithelial cell line (CALU3). Using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay as an indicator of cell proliferation/viability, we demonstrated a dose-dependent decrease of MTT metabolism by all flavors tested. However, a group of four flavors consistently showed significantly greater toxicity compared with the PG/VG control, indicating the potential for some flavors to elicit more harmful effects than others. We also tested the aerosolized "vapor" from select e-liquids on cells and found similar dose-dependent trends, suggesting that direct e-liquid exposures are a justifiable first-pass screening approach for determining relative e-liquid toxicity. We then identified individual chemical constituents for all 13 flavors using gas chromatography-mass spectrometry. These data revealed that beyond nicotine and PG/VG, the 13 flavored e-liquids have diverse chemical constituents. Since all of the flavors exhibited some degree of toxicity and a diverse array of chemical constituents with little inhalation toxicity available, we conclude that flavored e-liquids should be extensively tested on a case-by-case basis to determine the potential for toxicity in the lung and elsewhere.
[Mh] Termos MeSH primário: Sistemas Eletrônicos de Liberação de Nicotina
Células Epiteliais/citologia
Pulmão/citologia
[Mh] Termos MeSH secundário: Aerossóis
Morte Celular/efeitos dos fármacos
Linhagem Celular
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Cinnamomum aromaticum/química
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/metabolismo
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Concentração Inibidora 50
Mentol/farmacologia
Nicotina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 1490-04-6 (Menthol); 6M3C89ZY6R (Nicotine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1152/ajplung.00392.2016


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[PMID]:28258635
[Au] Autor:Lin CY; Hsieh YH; Yang SF; Chu SC; Chen PN; Hsieh YS
[Ad] Endereço:Institute of Biochemistry, Microbiology and Immunology, Chung Shang Medical University, Taichung City, Taiwan.
[Ti] Título:Cinnamomum cassia extracts reverses TGF-ß1-induced epithelial-mesenchymal transition in human lung adenocarcinoma cells and suppresses tumor growth in vivo.
[So] Source:Environ Toxicol;32(7):1878-1887, 2017 Jul.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Metastasis is the most common cause of cancer-related mortality in patients, and epithelial-mesenchymal transition (EMT) is essential for cancer metastasis and antidrug resistance. Cinnamomum cassia has several antioxidative, anti-inflammatory, and anticancer biological effects. However, the anti-EMT effect of C. cassia in human lung carcinoma is rarely reported. In this study, we determined whether C. cassia extracts (CCE) reduces the EMT and tumor growth of human lung adenocarcinoma cells. CCE inhibited the transforming growth factor (TGF)-ß1-induced cell motility and invasiveness of A549 and H1299 cells by repressing matrix metalloproteinase-2 and urokinase-type plasminogen activator as well as impaired cell adhesion to collagen. CCE also affected the TGF-ß1-induced EMT by downregulating the expression of vimentin and fibronectin and upregulating E-cadherin. The nude mice xenograft model showed that CCE reduced A549 tumor growth. Thus, CCE possesses antimetastatic activity of A549 and H1299 cells by affecting EMT and suppressing A549 tumor growth in vivo. This result suggested that CCE could be used as an antimetastatic agent or as an adjuvant for anticancer therapy.
[Mh] Termos MeSH primário: Adenocarcinoma/tratamento farmacológico
Antineoplásicos Fitogênicos/farmacologia
Cinnamomum aromaticum/química
Transição Epitelial-Mesenquimal/efeitos dos fármacos
Neoplasias Pulmonares/tratamento farmacológico
Extratos Vegetais/farmacologia
Fator de Crescimento Transformador beta1/farmacologia
[Mh] Termos MeSH secundário: Adenocarcinoma/metabolismo
Adenocarcinoma/patologia
Animais
Antineoplásicos Fitogênicos/uso terapêutico
Caderinas/metabolismo
Adesão Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Fibronectinas/metabolismo
Seres Humanos
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/patologia
Metaloproteinase 2 da Matriz/metabolismo
Camundongos Nus
Transplante de Neoplasias
Extratos Vegetais/uso terapêutico
Ativador de Plasminogênio Tipo Uroquinase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cadherins); 0 (FN1 protein, human); 0 (Fibronectins); 0 (Plant Extracts); 0 (Transforming Growth Factor beta1); EC 3.4.21.73 (Urokinase-Type Plasminogen Activator); EC 3.4.24.24 (Matrix Metalloproteinase 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22410


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[PMID]:28213163
[Au] Autor:Chandra Mohan C; Radha Krishnan K; Babuskin S; Sudharsan K; Aafrin V; Lalitha Priya U; Mariyajenita P; Harini K; Madhushalini D; Sukumar M
[Ad] Endereço:Centre for Food Technology, A.C.Tech., Anna University, Chennai 25, India.
[Ti] Título:Active compound diffusivity of particle size reduced S. aromaticum and C. cassia fused starch edible films and the shelf life of mutton (Capra aegagrus hircus) meat.
[So] Source:Meat Sci;128:47-59, 2017 Jun.
[Is] ISSN:1873-4138
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present study, mathematical models were used to examine the effect of active compound diffusion from edible film (supplemented with S. aromaticum and C. cassia) on the microbial, physical and chemical quality of mutton stored at 4 and 10°C. Cinnamaldehyde and eugenol release from edible film into liquid was found to be 80% and 75% of the equilibrium concentration. Active compound release into meat was 42-51% for cinnamaldehyde and 38-48% for eugenol, in storage temperatures of 4-15°C. Developed mathematical models showed the diffusivity of cinnamaldehyde (0.45×10 ±0.04×10 ) and eugenol (0.63×10 ±0.01×10 ) into meat, which was about 40% of that in liquid medium. On comparing physical, chemical and microbial results, shelf life of mutton meat was found to be increased by 1week at storage temperature of 10°C and 3weeks at storage temperature of 4°C.
[Mh] Termos MeSH primário: Cinnamomum aromaticum/química
Embalagem de Alimentos
Qualidade dos Alimentos
Carne/análise
Modelos Químicos
Especiarias/análise
Syzygium/química
[Mh] Termos MeSH secundário: Acroleína/análogos & derivados
Acroleína/análise
Acroleína/química
Algoritmos
Animais
Antioxidantes/análise
Antioxidantes/química
Temperatura Baixa
Difusão
Eugenol/análise
Eugenol/química
Conservação de Alimentos
Armazenamento de Alimentos
Cabras
Músculos Isquiotibiais
Índia
Cinética
Tamanho da Partícula
Amido/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 3T8H1794QW (Eugenol); 7864XYD3JJ (Acrolein); 9005-25-8 (Starch); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:27720465
[Au] Autor:Uchi H; Yasumatsu M; Morino-Koga S; Mitoma C; Furue M
[Ad] Endereço:Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: uchihir@dermatol.med.kyushu-u.ac.jp.
[Ti] Título:Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes.
[So] Source:J Dermatol Sci;85(1):36-43, 2017 Jan.
[Is] ISSN:1873-569X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dioxins and other environmental pollutants are toxic and remain in biological tissues for a long time leading to various levels of oxidative stress. Although the toxicity of these agents has been linked to activation of the aryl hydrocarbon receptor (AHR), no effective treatment has been developed. OBJECTIVE: To explore novel phytochemicals that inhibit AHR activation in keratinocytes. METHODS: Keratinocytes were used in this study because the skin is one of the organs most affected by dioxin and other environmental pollutants. HaCaT cells, which are a human keratinocyte cell line, and normal human epidermal keratinocytes were stimulated with benzo[a]pyrene to induce AHR activation, and the effects of traditional Japanese Kampo herbal formulae were analyzed. Quantification of mRNA, western blotting, immunofluorescence localization of molecules, siRNA silencing, and visualization of oxidative stress were performed. RESULTS: Cinnamomum cassia extract and its major constituent cinnamaldehyde significantly inhibited the activation of AHR. Cinnamaldehyde also activated the NRF2/HO1 pathway and significantly alleviated the production of reactive oxygen species in keratinocytes. The inhibition of AHR signaling and the activation of antioxidant activity by cinnamaldehyde operated in a mutually independent manner as assessed by siRNA methods In addition, AHR signaling was effectively inhibited by traditional Kampo formulae containing C. cassia. CONCLUSION: Cinnamaldehyde has two independent biological activities; namely, an inhibitory action on AHR activation and an antioxidant effect mediated by NRF2/HO1 signaling. Through these dual functions, cinnamaldehyde may be beneficial for the treatment of disorders related to oxidative stress such as dioxin intoxication, acne, and vitiligo.
[Mh] Termos MeSH primário: Acroleína/análogos & derivados
Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo
Cinnamomum aromaticum/química
Fator 2 Relacionado a NF-E2/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Receptores de Hidrocarboneto Arílico/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acroleína/farmacologia
Antioxidantes/farmacologia
Benzo(a)pireno/metabolismo
Linhagem Celular
Dioxinas/toxicidade
Poluentes Ambientais/toxicidade
Epiderme/citologia
Epiderme/efeitos dos fármacos
Epiderme/metabolismo
Heme Oxigenase-1/metabolismo
Seres Humanos
Queratinócitos/efeitos dos fármacos
Queratinócitos/metabolismo
Medicina Kampo
Fator 2 Relacionado a NF-E2/genética
Oxirredução/efeitos dos fármacos
Extratos Vegetais/farmacologia
Interferência de RNA
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AHR protein, human); 0 (Antioxidants); 0 (Basic Helix-Loop-Helix Transcription Factors); 0 (Dioxins); 0 (Environmental Pollutants); 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (Receptors, Aryl Hydrocarbon); 3417WMA06D (Benzo(a)pyrene); 7864XYD3JJ (Acrolein); EC 1.14.14.18 (HMOX1 protein, human); EC 1.14.14.18 (Heme Oxygenase-1); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:26842885
[Au] Autor:Park S; Kang S; Kim DS; Moon BR
[Ad] Endereço:a Department of Food and Nutrition , Obesity/Diabetes Center, Hoseo University , 165 Sechul-Ri, BaeBang-Yup, Asan-Si, ChungNam-Do 336-795 , South Korea.
[Ti] Título:Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in ß-amyloid-infused rats.
[So] Source:Nutr Neurosci;20(2):77-88, 2017 Feb.
[Is] ISSN:1476-8305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The water extracts of Cinnamomum cassia Blume bark (CCB; Lauraceae), Lonicera japonica Thunb. flower (LJT; Caprifoliaceae), and Agrimonia pilosa Ledeb. leaves (APL; Rosaceae) prevented amyloid-ß (25-35)-induced cell death in PC12 cells in our preliminary study. We evaluated whether long-term oral consumption of CCB, LJT, and APL improves cognitive dysfunction and glucose homeostasis in rats with experimentally induced AD-type dementia. METHODS: Male rats received hippocampal CA1 infusions of amyloid-ß (25-35, AD) or amyloid-ß (35-25, non-plaque forming, normal-controls, Non-AD-CON), at a rate of 3.6 nmol/day for 14 days. AD rats were divided into four groups receiving either 2% lyophilized water extracts of CCB, LJT, or APL or 2% dextrin (AD-CON) in high-fat diets (43% energy as fat). RESULTS: Hippocampal amyloid-ß deposition, tau phosphorylation, and expressions of tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS) (neruoinflammation markers) were increased, and insulin signaling decreased in AD-CON. CCB, LJT, and APL all prevented hippocampal amyloid-ß accumulation and enhanced hippocampal insulin signaling. CCB, LJT, and APL decreased TNF-α and iNOS in the hippocampus and especially APL exhibited the greatest decrease. AD-CON exhibited cognitive dysfunction in passive avoidance and water maze tests, whereas CCB, LJT, and APL protected against cognitive dysfunction, and APL was most effective and was similar to Non-AD-CON. AD-CON had less fat oxidation as an energy fuel, but it was reversed by CCB, LJT, and especially APL. APL-treated rats had less visceral fat than AD-CON rats. AD-CON rats exhibited impaired insulin sensitivity and increased insulin secretion during oral glucose tolerance test compared with Non-AD-CON, but CCB and APL prevented the impairment. DISCUSSION: These results supported that APL, LJT, and CCB effectively prevent the cognitive dysfunction and the impairment of energy and glucose homeostasis induced by amyloid-ß deposition by reducing neuroinflammation and enhancing insulin signaling. APL exhibited the greatest effectiveness for improving cognitive function.
[Mh] Termos MeSH primário: Agrimonia/química
Doença de Alzheimer/dietoterapia
Cinnamomum aromaticum/química
Modelos Animais de Doenças
Lonicera/química
Nootrópicos/uso terapêutico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Doença de Alzheimer/metabolismo
Doença de Alzheimer/patologia
Doença de Alzheimer/fisiopatologia
Animais
Comportamento Animal
Biomarcadores/metabolismo
Disfunção Cognitiva/etiologia
Disfunção Cognitiva/prevenção & controle
Metabolismo Energético
Flores/química
Intolerância à Glucose/etiologia
Intolerância à Glucose/prevenção & controle
Hipocampo/imunologia
Hipocampo/metabolismo
Hipocampo/patologia
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/uso terapêutico
Resistência à Insulina
Masculino
Neurônios/imunologia
Neurônios/metabolismo
Neurônios/patologia
Nootrópicos/isolamento & purificação
Casca de Planta/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Ratos Sprague-Dawley
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Hypoglycemic Agents); 0 (Nootropic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.1080/1028415X.2015.1135572


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[PMID]:27780753
[Au] Autor:Sun L; Zong SB; Li JC; Lv YZ; Liu LN; Wang ZZ; Zhou J; Cao L; Kou JP; Xiao W
[Ad] Endereço:Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, Jiangsu 211198, PRChina; State Key Laboratory of New-tech For Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd., Li
[Ti] Título:The essential oil from the twigs of Cinnamomum cassia Presl alleviates pain and inflammation in mice.
[So] Source:J Ethnopharmacol;194:904-912, 2016 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Cinnamomum cassia Presl (Lauraceae) can be found southern China and its bark is commonly used for centuries as ingredient in food and cosmetic industry. The twigs of Cinnamomum cassia Presl is popularly used in China to treat inflammatory processes, pain, menstrual disorders, hypertension, fever etc. The aim of this study is to evaluate the antinociceptive and anti-inflammatory properties of the essential oil (EO) from the twigs of Cinnamomum cassia Presl. MATERIAL AND METHODS: The chemical characterization of the EO was performed by gas chromatography coupled with mass spectrometry (GC-MS). The EO doses of 15, 30, and 60mg/kg were employed in the biological assays. The antinociceptive effects of the EO were evaluated using the models of acetic acid-induced writhing, oxytocin-induced writhing, and formalin and complete Freund's adjuvant (CFA) -induced overt pain tests. we also investigated the effect of the EO in pain intensity to a mechanical stimulus (mechanical hyperalgesia) after carrageenan by using an electronic version of von Frey filaments. Evaluation of anti-inflammatory activity was based on paw edema induced by carrageenan (300µg/25µL/paw) in mice. The levels of cytokines, NO, and PGE2 in paw skin tissue were determined according to instructions. COX-2 and iNOS proteins in paw skin tissue were assessed by Western Blot. RESULTS: The EO (15, 30, and 60mg/kg) reduced the number of abdominal writhings induced by acetic acid with inhibition of 38.0%, 55.4% and 58.7%, respectively. The EO (15, 30, and 60mg/kg) also reduced the number of abdominal writhings induced by oxytocin with inhibition of 27.3%, 51.7% and 69.0%, respectively. The EO significant inhibited the inflammatory (second phase: 10-30min) phase of the formalin-induced paw flinching and licking at the doses of 15, 30, and 60mg/kg. The EO at the tested doses of 15, 30, and 60mg/kg showed inhibited CFA-induced paw flinching and licking. The EO (15, 30, and 60mg/kg) also inhibited carrageenan-induced mechanical hyperalgesia and paw edema. It also decreased the levels of cytokines (TNF-α, and IL-1ß), NO, and PGE2 in carrageenan-induced mice paw skin tissue. Moreover, Western blot analysis showed that COX-2 and iNOS expressions in paw skin tissue of mice were significantly reduced. CONCLUSIONS: These results demonstrate that the antinociceptive and anti-inflammatory properties of the EO from the twigs of Cinnamomum cassia Presl, corroborating its use in folk medicine.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Cinnamomum aromaticum/química
Inflamação/tratamento farmacológico
Óleos Voláteis/farmacologia
Dor/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/química
Analgésicos/farmacologia
Animais
Carragenina/farmacologia
Edema/induzido quimicamente
Edema/tratamento farmacológico
Feminino
Inflamação/induzido quimicamente
Masculino
Camundongos
Camundongos Endogâmicos ICR
Dor/induzido quimicamente
Fitoterapia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Oils, Volatile); 0 (Plant Extracts); 9000-07-1 (Carrageenan)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE



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