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[PMID]:28467186
[Au] Autor:Zhang Y; Chen H; Critzer F; Davidson PM; Zhong Q
[Ad] Endereço:Department of Food Science and Technology, 2510 River Drive, University of Tennessee, Knoxville, Tennessee 37996, USA.
[Ti] Título:Potential of Cinnamon Oil Emulsions as Alternative Washing Solutions of Carrots.
[So] Source:J Food Prot;80(6):994-1001, 2017 06.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the potential of cinnamon oil emulsions as alternative washing solutions to improve the microbial safety of carrots. Whey protein concentrate (WPC), gum arabic (GA), lecithin, and their combinations were used to prepare cinnamon oil emulsions. The emulsions were characterized for their hydrodynamic diameter (D ) during 7 days of storage and their antimicrobial activity against cocktails of Salmonella enterica , Escherichia coli O157:H7, and Listeria monocytogenes . The D of the emulsion prepared with the GA+WPC blend did not change significantly (195.0 to 184.1 nm), whereas all other emulsions showed varying degrees of increases in D . Compared with free cinnamon oil dissolved in 5% ethanol, all emulsions showed similar or lower MICs and MBCs. Emulsions prepared with GA and equal masses of GA and WPC were chosen and diluted to 0.2 and 0.5% cinnamon oil to wash carrots that were surface inoculated with bacterial cocktails because of their lower MICs and MBCs than free oil. Emulsions resulted in significantly higher reductions of pathogens on carrots than free cinnamon oil, 3.0 to 3.7 versus 2.1 to 2.3 log CFU/g at 0.5% cinnamon oil and 2.0 to 3.0 versus 1.0 to 1.7 log CFU/g at 0.2% cinnamon oil. No transfer of bacteria from inoculated carrots to wash solutions and no effects of organic load on log reductions were only observed for wash treatments with 0.5% emulsified cinnamon oil. Thus, the cinnamon oil emulsions are potential alternative postharvest washing solutions for fresh produce production.
[Mh] Termos MeSH primário: Daucus carota
Emulsões
[Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia
Cinnamomum zeylanicum
Contagem de Colônia Microbiana
Escherichia coli O157/efeitos dos fármacos
Microbiologia de Alimentos
Listeria monocytogenes/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Emulsions)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-359


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[PMID]:29282046
[Au] Autor:Ranasinghe P; Jayawardena R; Pigera S; Wathurapatha WS; Weeratunga HD; Premakumara GAS; Katulanda P; Constantine GR; Galappaththy P
[Ad] Endereço:Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. priyanga.ranasinghe@gmail.com.
[Ti] Título:Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial.
[So] Source:BMC Complement Altern Med;17(1):550, 2017 Dec 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The present study aims to evaluate Pharmacodynamic properties and safety of CZ in healthy adults using a Phase I Clinical Trial. METHODS: This phase I clinical trial was conducted at the Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka. Thirty healthy adults were recruited for the study, conducted for a period of 3 months, with the dose of CZ (water extract) increased at monthly intervals (85 mg, 250 mg and 500 mg). Data collection was carried out at baseline and during each monthly follow up visit. Anthropometric, clinical and biochemical assessments were done at baseline and during follow up. Adverse effects and drug compliance was also evaluated. RESULTS: Twenty eight subjects completed the three months follow up. Mean age was 38.8 ± 10.4 years and 50% were males. There were no significant changes in the anthropometric parameters during the three months follow up. Both systolic and diastolic blood pressure reduced significant during the 1st month and this reduction was sustained throughout follow up. Full blood count, renal function tests, liver function tests, fasting blood glucose, HDL-c, VLDL-d and triglycerides remained within the normal range without any significant alteration during the 3 months. A significant reduction in the TC (p < 0.05) and LDL-c (p < 0.001) was noted at the end of the 3 months follow up period. There were no serious adverse effects (including hypersensitivity) noted. In two participants dyspepsia necessitated the discontinuation of study participation. Drug compliance was between 85 and 95% during the study period. CONCLUSIONS: This is the first phase I clinical trial in health adults evaluating efficacy and safety of CZ. Our results demonstrate no significant side effects and toxicity of CZ, including hepatotoxicity and anti-coagulation properties. CZ demonstrated beneficial anti-hyperlipidaemic and blood pressure lowering effects among healthy adults. Further studies with larger samples and longer durations may be able to elucidate other side effects and better describe the pharmacodynamic properties. TRIAL REGISTRATION: SLCTR/2013/001 (Sri Lanka Clinical Trials Registry: http://www.slctr.lk/trials/106 ) (Date of Registration: 01/01/2013).
[Mh] Termos MeSH primário: Cinnamomum zeylanicum
Extratos Vegetais/efeitos adversos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Adulto
Pressão Sanguínea/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Feminino
Seres Humanos
Masculino
Meia-Idade
Pulso Arterial
Sri Lanka
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2067-7


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[PMID]:29267351
[Au] Autor:Bastos MS; Del Vesco AP; Santana TP; Santos TS; de Oliveira Junior GM; Fernandes RPM; Barbosa LT; Gasparino E
[Ad] Endereço:Animal Science Department, Federal University of Sergipe, São Cristóvão s/n, Brazil.
[Ti] Título:The role of cinnamon as a modulator of the expression of genes related to antioxidant activity and lipid metabolism of laying quails.
[So] Source:PLoS One;12(12):e0189619, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since cinnamon has vitamins and minerals in addition to antioxidants compounds in its chemical composition studies have shown the potential of cinnamon supplementation on some important characteristics in the performance of birds. Thus, this study was conducted under the hypothesis that the inclusion of cinnamon in the laying quail diet could influence the performance of the birds through the expression of genes related to antioxidant activity and lipid metabolism. To test this hypothesis, 144 Japanese quail (Coturnix japonica) with an initial age of 18 weeks and average weight of 133g were distributed in a completely randomized design with two treatments: no cinnamon supplementation (NCS-control group) and with supplementation of 9g/kg of cinnamon powder (CPS). The experiment lasted for 84 days. At the end of the experimental period, six animals from each treatment were euthanized by cervical dislocation, blood was collected and organs weighed. Liver tissue was collected for gene expression and biochemical analyses. We observed a significant effect of cinnamon inclusion on the weight of the pancreas (P = 0.0418), intestine (P = 0.0209) and ovary (P = 0.0389). Lower weights of the pancreas and intestine, and a higher ovary weight was observed in birds receiving the CPS diet. Quails fed with cinnamon supplementation also had better feed conversion per egg mass (2.426 g /g, P = 0.0126), and higher triglyceride (1516.60 mg/dL, P = 0.0207), uric acid (7.40 mg/dL, P = 0.0003) and VLDL (300.40 mg/dL, P = 0.0252) contents. A decreased content of thiobarbituric acid reactive substances (TBARS) and lower catalase activity was observed in the liver of quails from the CPS diet (0.086 nmoles/mg PTN, and 2.304 H2O2/min/mg PTN, respectively). Quails from the CPS group presented significantly greater expression of FAS (fatty acid synthase, 36,03 AU), ACC (Acetyl-CoA Carboxylase, 31.33 AU), APOAI (apolipoprotein A-I, 803,9 AU), ESR2 (estrogen receptor 2, 0.73 AU) SOD (superoxide dismutase, 4,933.9 AU) and GPx7 (glutathione peroxidase 7, 9.756 AU) than quails from the control group. These results allow us to suggest that cinnamon powder supplementation in the diet of laying quails can promote balance in the metabolism and better performance through the modulation of antioxidant activity and the expression of genes related to lipid metabolism.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Cinnamomum zeylanicum
Coturnix/genética
Regulação da Expressão Gênica/efeitos dos fármacos
Metabolismo dos Lipídeos
[Mh] Termos MeSH secundário: Animais
Catalase/metabolismo
Tamanho da Ninhada
Coturnix/metabolismo
Coturnix/fisiologia
Feminino
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Thiobarbituric Acid Reactive Substances); EC 1.11.1.6 (Catalase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189619


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[PMID]:28873538
[Au] Autor:Krüger S; Winheim L; Morlock GE
[Ad] Endereço:Justus Liebig University Giessen, Institute of Nutritional Science, Chair of Food Sciences, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
[Ti] Título:Planar chromatographic screening and quantification of coumarin in food, confirmed by mass spectrometry.
[So] Source:Food Chem;239:1182-1191, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A sensitive quantitative screening of coumarin in 43 commercially available cinnamons and cinnamon-containing foods was developed via HPTLC. Complex samples like cinnamon, tea, breakfast cereals, milk rice, jam, cinnamon stars and buns were extracted with methanol only. Separation was performed on silica gel with a mixture of n-hexane, ethyl acetate and ammonia. The specific detection via derivatization with an ethanolic potassium hydroxide solution resulted in fluorescent coumarin zones, measured at 365/>400nm after stabilization. Limits of detection and quantification were 200 and 400pg/band, respectively. Over all different sample types, the contents ranged from 0.3 to 5129mg/kg with a mean repeatability and mean intermediate precision of 4% each. HPTLC-MS of selected zones, eluted via the TLC-MS Interface into MS, confirmed the identity of coumarin. Effect-directed detection as bioanalytical tool for risk assessment showed coumarin to be active against Aliivibrio fischeri bacteria down to 100ng/band.
[Mh] Termos MeSH primário: Cumarínicos/análise
[Mh] Termos MeSH secundário: Cromatografia em Camada Delgada
Cinnamomum zeylanicum
Alimentos
Hexanos
Espectrometria de Massas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Hexanes); 2DDG612ED8 (n-hexane)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:29023481
[Au] Autor:Vendan SE; Manivannan S; Sunny AM; Murugesan R
[Ad] Endereço:Food Protectants and Infestation Control Department, CSIR-Central Food Technological Research Institute, Mysore, India.
[Ti] Título:Phytochemical residue profiles in rice grains fumigated with essential oils for the control of rice weevil.
[So] Source:PLoS One;12(10):e0186020, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the present study, we investigated the fumigant potential of five edible essential oils (EOs) against Sitophilus oryzae and their phytochemical residues in treated grains. Among the tested EOs, peppermint oil proved significantly effective (P ≤ 0.05) on S.oryzae at 400 µl/L air concentration, inducing 83 and 100% mortalities in with-food and without-food conditions respectively over 72 h exposure. In addition, it was also observed that the binary mixtures of peppermint + lemon oil (1:1 ratio) produced an equivalent effect to that of peppermint oil alone treatments. The phytochemical residue analysis by GC-MS revealed the presence of six compounds upon 72 h exposure to EOs. Further, the analysis of physico-chemical properties of the compounds indicated a positive correlation between polar surface area (PSA) and its residual nature. The residue levels of eugenol were significantly elevated corresponding to its high PSA value (29) in clove and cinnamon oils. On the other hand, the compounds with zero PSA value imparted very less or no (D-Limonene, caryophyllene, pinene and terpinolene) residues in treated grains. With respect to the most active peppermint oil, L-menthone, menthyl acetate and eucalyptol residues were at 67, 41 and 23% levels respectively. The outcome of the present study indicate the peppermint oil as a potent fumigant against S. oryzae, and although the residues of phytochemicals in treated grains is higher; they belong to the generally recognised as safe (GRAS) status leaving no harmful effect.
[Mh] Termos MeSH primário: Inseticidas/farmacologia
Óleos Voláteis/farmacologia
Oryza/química
Resíduos de Praguicidas/análise
Gorgulhos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cinnamomum zeylanicum/química
Óleo de Cravo/química
Óleo de Cravo/farmacologia
Fumigação
Óleos Voláteis/química
Oryza/efeitos dos fármacos
Resíduos de Praguicidas/química
Óleos Vegetais/química
Óleos Vegetais/farmacologia
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Clove Oil); 0 (Insecticides); 0 (Oils, Volatile); 0 (Pesticide Residues); 0 (Plant Oils); AKN3KSD11B (orange oil); AV092KU4JH (peppermint oil); I9GRO824LL (lemon oil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186020


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[PMID]:28813148
[Au] Autor:Kamel KM; Khalil IA; Rateb ME; Elgendy H; Elhawary S
[Ti] Título:Chitosan-Coated Cinnamon/Oregano-Loaded Solid Lipid Nanoparticles to Augment 5-Fluorouracil Cytotoxicity for Colorectal Cancer: Extract Standardization, Nanoparticle Optimization, and Cytotoxicity Evaluation.
[So] Source:J Agric Food Chem;65(36):7966-7981, 2017 Sep 13.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to coat lipid-based nanocarriers with chitosan to encapsulate nutraceuticals, minimize opsonization, and facilitate passive-targeting. Phase one was concerned with standardization according to the World Health Organization. Qualitative analysis using liquid chromatography-high-resolution mass spectrometry (LC-HRMS/MS) investigated the active constituents, especially reported cytotoxic agents. Cinnamaldehyde and rosmarinic acid were selected to be quantified using high-performance liquid chromatography. Phase two was aimed to encapsulate both extracts in solid lipid nanoparticles (core) and chitosan (shell) to gain the advantages of both materials properties. The developed experimental model suggested an optimum formulation with 2% lipid, 2.3% surfactant, and 0.4% chitosan to achieve a particle size of 254.77 nm, polydispersity index of 0.28, zeta potential of +15.26, and entrapment efficiency percentage of 77.3% and 69.1% for cinnamon and oregano, respectively. Phase three was focused on the evaluation of cytotoxic activity unencapsulated/encapsulated cinnamon and oregano extracts with/without 5-fluorouracil on HCT-116 cells. This study confirmed the success of the suggested combination with 5-fluorouracil for treating human colon carcinoma with a low dose leading to decreasing side effects and allowing uninterrupted therapy.
[Mh] Termos MeSH primário: Antineoplásicos/química
Quitosana/química
Cinnamomum zeylanicum/química
Fluoruracila/química
Lipídeos/química
Origanum/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antineoplásicos/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Neoplasias Colorretais/tratamento farmacológico
Neoplasias Colorretais/fisiopatologia
Portadores de Fármacos/química
Fluoruracila/farmacologia
Células HCT116
Seres Humanos
Nanopartículas/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Drug Carriers); 0 (Lipids); 0 (Plant Extracts); 9012-76-4 (Chitosan); U3P01618RT (Fluorouracil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b03093


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[PMID]:28694207
[Au] Autor:Liao Z; Wang J; Tan H; Wei L
[Ad] Endereço:Affiliated Hospital of YouJiang Medical University for Nationalities, Baise, Guangxi 533000, PR China; The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530007, PR China.
[Ti] Título:Cinnamon extracts exert intrapancreatic cytoprotection against streptozotocin in vivo.
[So] Source:Gene;627:519-523, 2017 Sep 05.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the current study, we aimed to investigate the potential hypoglycemic bioactivity of cinnamon extracts (CES) on streptozotocin (STZ)-induced hyperglycemia in mice. In biological methods, glucose metabolic ability of all mice was evaluated by glucose tolerance testing (GTT). Blood levels of pancreas-produced insulin, glucagon, inflammation-associated interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) were determined via enzyme-linked immunosorbent assay (ELISA). In gene level, intrapancreatic mRNA expressions of insulin, TNF-α and nuclear-factor kappa B (NF-κB) were assayed by reverse transcription polymerase chain reaction (RT-PCR). Meanwhile, intracellular insulin-immunoactive cells in the pancreas were analyzed by using immunohistochemical staining. In addition, the protein levels of intrapancreatic NF-κB, IκB (p-IκB) and IKK were tested by western blotting. As a result, CES-treated mice showed increased body weight, blood glucose and insulin, reduced IL-6 and TNF-α contents in sera. Further, the TNF-α and NF-κB mRNA expressions in the CES-treated pancreas were down-regulated at a dose-dependent manner, while insulin mRNA was elevated. Moreover, the reduced intrapancreatic NF-κB, IκB (p-IκB) and IKK expression were observed in CES-treated pancreas, respectively. Taken together, our current findings indicate that CES-mediated intrapancreatic cytoprotection is linked to the molecular mechanism that may be through inhibiting inflammatory stress and promoting insulin secretion in the pancreas.
[Mh] Termos MeSH primário: Cinnamomum zeylanicum/química
Hiperglicemia/tratamento farmacológico
Pâncreas/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Hiperglicemia/etiologia
Hiperglicemia/metabolismo
Quinase I-kappa B/genética
Quinase I-kappa B/metabolismo
Proteínas I-kappa B/genética
Proteínas I-kappa B/metabolismo
Insulina/secreção
Interleucina-6/genética
Interleucina-6/metabolismo
Camundongos
NF-kappa B/genética
NF-kappa B/metabolismo
Pâncreas/metabolismo
Extratos Vegetais/farmacologia
Estreptozocina/toxicidade
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (I kappa B beta protein); 0 (I-kappa B Proteins); 0 (Insulin); 0 (Interleukin-6); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 5W494URQ81 (Streptozocin); EC 2.7.11.10 (I-kappa B Kinase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE


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[PMID]:28603113
[Au] Autor:Ullah N; Khan MA; Khan S; Roohullah -; Khan A; Ahmad W
[Ad] Endereço:Department of Pharmacy, University of Swabi, Swabi, KPK, Pakistan.
[Ti] Título:Nephroprotective property of Cinnamomum zeylanicum and its antibacterial activity in combination with gantamicin.
[So] Source:Pak J Pharm Sci;30(1):55-60, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Cinnamomum zeylanicum has strong antioxidant properties and has been presented to have nephroprotective effects. Present work was aimed to study the nephroprotective property of the plant extract through urinary enzymes excretion, to confirm its protective effects and to observe the antibacterial activities of gentamicin in combination with the plant extract. 200mg/kg/day of the plant extracts were administered alone and as co-therapy with gentamicin. Urinary lactate dehydrogenase (LDH) and Urinary alkaline phospatase (ALP) excretions were observed through reagents kits with the help of Power-Lab 300. Antibacterial activities were assessed for gentamicin alone and in combination with the extract. Present study showed that the plant extract have excess quantity of flavonoids, which may responsible for attenuating the excessive excretion of urinary LDH. However, Urinary ALP excretion was found remained same throughout the study period in all experimental groups; might be detected in acute damage. Further, the plant also proved to have no decreasing impact on the antibacterial activities of gentamicin.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Cinnamomum zeylanicum/química
Gentamicinas/farmacologia
Rim/efeitos dos fármacos
Compostos Fitoquímicos/farmacologia
Agentes Urológicos/farmacologia
[Mh] Termos MeSH secundário: Fosfatase Alcalina/urina
Animais
Antibacterianos/isolamento & purificação
Bactérias/crescimento & desenvolvimento
Citoproteção
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Quimioterapia Combinada
Rim/enzimologia
L-Lactato Desidrogenase/urina
Compostos Fitoquímicos/isolamento & purificação
Fitoterapia
Plantas Medicinais
Coelhos
Agentes Urológicos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gentamicins); 0 (Phytochemicals); 0 (Urological Agents); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28525761
[Au] Autor:Mateo EM; Gómez JV; Domínguez I; Gimeno-Adelantado JV; Mateo-Castro R; Gavara R; Jiménez M
[Ad] Endereço:Department of Microbiology and Ecology, University of Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia, Spain.
[Ti] Título:Impact of bioactive packaging systems based on EVOH films and essential oils in the control of aflatoxigenic fungi and aflatoxin production in maize.
[So] Source:Int J Food Microbiol;254:36-46, 2017 Aug 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Aspergillus flavus and A. parasiticus are the most common fungal species associated with aflatoxin (AF) contamination of cereals, especially maize, and other agricultural commodities. AFB the most frequent and toxic metabolite, is a powerful hepatotoxic, teratogenic and mutagenic compound. Effective strategies to control these fungal species and AFs in food and feed are required. Active packaging film containing essential oils (EO) is one of the most innovative food packaging concepts. In this study, ethylene-vinyl alcohol (EVOH) copolymer films incorporating EO from Origanum vulgare (ORE), Cinnamomum zeylanicum (CIN) or their major active constituents, carvacrol (CAR) and cinnamaldehyde (CINHO), respectively, were developed and assayed to control growth of A. flavus and A. parasiticus and AF production in maize grains under different a and temperature regimens. EO doses assayed in cultures were in the range 0.25-4.0mg/Petri dish. The factors a , temperature, type of EVOH-EO film and fungal species significantly influenced the ED values of all assayed films. Growth rate (GR) of both species was usually higher at 0.99 than at 0.96 a and at 37°C than at 25°C. However, the contrary was found with regard to AF production. The order of efficacy of EVOH-EO films to control growth of both species and AF production was EVOH-CINHO>EVOH-CAR>EVOH-ORE>EVOH-CIN. The effective dose (ED ) (mg EO/plate) for EVOH-CINHO and EVOH-CIN films against A. flavus were in the ranges of 0.125 and 2.475-3.500 and against A. parasiticus in the ranges of 0.121-0.133 and 2.275-3.625, respectively. Under the assayed conditions, the ED for EVOH-CINHO film were 0.22-0.23mg/plate for both species. It was the most effective bioactive film to control fungal growth (vapour phase) and AF production, regardless of a and temperature. This is the first study about the impact that interacting environmental conditions and bioactive EVOH-CINHO, EVOH-ORE, EVOH-CIN EVOH-CAR films have on the growth of aflatoxigenic fungi and on AF production in maize grains.
[Mh] Termos MeSH primário: Acroleína/análogos & derivados
Antifúngicos/farmacologia
Aspergillus flavus/crescimento & desenvolvimento
Monoterpenos/farmacologia
Óleos Voláteis/farmacologia
Polivinil/farmacologia
Zea mays/microbiologia
[Mh] Termos MeSH secundário: Acroleína/farmacologia
Aflatoxinas/biossíntese
Cinnamomum zeylanicum/metabolismo
Microbiologia de Alimentos/métodos
Embalagem de Alimentos
Origanum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Antifungal Agents); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Polyvinyls); 25067-34-9 (ethylene-vinyl alcohol copolymer); 7864XYD3JJ (Acrolein); 9B1J4V995Q (carvacrol); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


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[PMID]:28444928
[Au] Autor:Han X; Parker TL
[Ad] Endereço:doTERRA International, LLC, 389 S. 1300 W, Pleasant Grove, UT, 84062, USA.
[Ti] Título:Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model.
[So] Source:Phytother Res;31(7):1034-1038, 2017 Jul.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) on human skin cells has not been elucidated. Therefore, we investigated the activity of a commercially available CBEO in a validated human dermal fibroblast system, a model of chronic inflammation and fibrosis. We first evaluated the impact of CBEO on 17 protein biomarkers that play critical roles in inflammation and tissue remodeling. The impact of CBEO on genome-wide gene expression was also evaluated. CBEO showed strong anti-proliferative effects on skin cells and significantly inhibited the production of several inflammatory biomarkers, including vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interferon gamma-induced protein 10, interferon-inducible T-cell alpha chemoattractant, and monokine induced by gamma interferon. In addition, CBEO significantly inhibited the production of several tissue remodeling molecules, including epidermal growth factor receptor, matrix metalloproteinase-1, and plasminogen activator inhibitor-1. Macrophage colony-stimulating factor, which is an immunomodulatory protein molecule, was also significantly inhibited by CBEO. Furthermore, CBEO significantly modulated global gene expression and altered signaling pathways, many of which are important in inflammation, tissue remodeling, and cancer biology. The study shows that CBEO is a promising antiinflammatory agent; however, further research is required to clarify its clinical efficacy. © 2017 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Cinnamomum zeylanicum/química
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
Dermatopatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Células Cultivadas
Quimiocina CCL2/metabolismo
Quimiocina CXCL10/metabolismo
Fibroblastos/efeitos dos fármacos
Seres Humanos
Molécula 1 de Adesão Intercelular/metabolismo
Fator Estimulador de Colônias de Macrófagos/metabolismo
Metaloproteinase 1 da Matriz/metabolismo
Fitoterapia
Casca de Planta/química
Inibidor 1 de Ativador de Plasminogênio/metabolismo
Molécula 1 de Adesão de Célula Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (CCL2 protein, human); 0 (CXCL10 protein, human); 0 (Chemokine CCL2); 0 (Chemokine CXCL10); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plasminogen Activator Inhibitor 1); 0 (SERPINE1 protein, human); 0 (Vascular Cell Adhesion Molecule-1); 126547-89-5 (Intercellular Adhesion Molecule-1); 81627-83-0 (Macrophage Colony-Stimulating Factor); EC 3.4.24.7 (MMP1 protein, human); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5822



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