Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.595.400.177 [Categoria DeCS]
Referências encontradas : 47 [refinar]
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[PMID]:28304234
[Au] Autor:Carmona ER; Reyes-Díaz M; Parodi J; Inostroza-Blancheteau C
[Ad] Endereço:a Núcleo de Investigación en Bioproductos y Materiales Avanzados (BioMA), Facultad de Ingeniería , Universidad Católica de Temuco , Temuco , Chile.
[Ti] Título:Antimutagenic evaluation of traditional medicinal plants from South America Peumus boldus and Cryptocarya alba using Drosophila melanogaster.
[So] Source:J Toxicol Environ Health A;80(4):208-217, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Peumus boldus Mol. ("Boldo") and Cryptocarya alba Mol. Looser ("Peumo") are medicinal shrubs with wide geographical distribution in South America. Their leaves and fruits are commonly used in traditional medicine because they exhibit natural medicinal properties for treatment of liver disorders and rheumatism. However, there are no apparent data regarding potential protective effects on cellular genetic components. In order to examine potential mutagenic and/or antimutagenic effects of these medicinal plants, the Drosophila melanogaster (D. melanogaster) wing-spot test was employed. This assay detects a wide range of mutational events, including point mutations, deletions, certain types of chromosomal aberrations (nondisjunction), and mitotic recombination. Qualitative and quantitative analyses of phenolic and anthocyanin compounds were carried out using biochemical and high-performance liquid chromatography methodologies. In addition, the antioxidant capacity of P. boldus and C. alba leaf extracts was also analyzed. P. boldus and C. alba extracts did not induce significant mutagenic effects in the D. melanogaster model. However, simultaneous treatment of extracts concurrently with the mutagen ethyl methane sulphonate showed a decrease of mutant spots in somatic cells of D. melanogaster, indicating desmutagenic effects in this in vivo model. Flavonoids and anthocyanins were detected predominantly in the extracts, and these compounds exerted significant antioxidant capacity. The observed antimutagenic effects may be related to the presence of phytochemicals with high antioxidant capacity, such as flavonoids and antohocyanins, in the extracts.
[Mh] Termos MeSH primário: Antimutagênicos/farmacologia
Cryptocarya/química
Drosophila melanogaster/efeitos dos fármacos
Peumus/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Antocianinas/análise
Antocianinas/farmacologia
Antioxidantes/análise
Antioxidantes/farmacologia
Chile
Drosophila melanogaster/crescimento & desenvolvimento
Metanossulfonato de Etila/metabolismo
Larva/efeitos dos fármacos
Mutagênicos/metabolismo
Fenóis/análise
Fenóis/farmacologia
Extratos Vegetais/química
Folhas de Planta/química
Asas de Animais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antimutagenic Agents); 0 (Antioxidants); 0 (Mutagens); 0 (Phenols); 0 (Plant Extracts); 9H154DI0UP (Ethyl Methanesulfonate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1279574


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[PMID]:28099003
[Au] Autor:Suzuki Y; Saito Y; Goto M; Newman DJ; O'Keefe BR; Lee KH; Nakagawa-Goto K
[Ad] Endereço:School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University , Kanazawa, 920-1192, Japan.
[Ti] Título:(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.
[So] Source:J Nat Prod;80(1):220-224, 2017 Jan 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Twelve benzylisoquinoline alkaloids, including pavine and phenanthroindolizidine types, were isolated from a MeOH/CH Cl extract of Cryptocarya laevigata (stem bark) through bioactivity-guided fractionation for antitumor effects. Selected compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a multidrug-resistant subline. Since more common 2,3,8,9-tetrasubstituted pavine alkaloids, such as crychine (3), exhibit very mild or no cytotoxicity, this compound type has not been well investigated for antitumor activity. Thus, this report is the first discovery of a 7-hydroxylated pavine alkaloid, (-)-neocaryachine (1), to demonstrate strong antiproliferative activity, with IC values of 0.06 to 0.41 µM against five tested tumor cell lines, including an MDR subline. Further mechanism of action studies revealed that 1 impacts the cellular S-phase by inducing DNA double-strand breaks.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Proliferação Celular/efeitos dos fármacos
Cryptocarya/química
DNA/química
Dioxóis/isolamento & purificação
Dioxóis/farmacologia
Indolizinas/isolamento & purificação
Fenantrolinas/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/farmacologia
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
DNA/metabolismo
Dioxóis/química
Seres Humanos
Indolizinas/química
Indolizinas/farmacologia
Estrutura Molecular
Fenantrolinas/química
Fenantrolinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Dioxoles); 0 (Indolizines); 0 (Phenanthrolines); 0 (phenanthroindolizidine); 4040-75-9 (crychine); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b01153


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[PMID]:27830587
[Au] Autor:Yang BY; Shi YM; Luo JG; Kong LY
[Ad] Endereço:a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , People's Republic of China.
[Ti] Título:Two new arylalkenyl α,ß-unsaturated δ-lactones with cytotoxic activity from the leaves and twigs of Cryptocarya concinna.
[So] Source:Nat Prod Res;31(12):1409-1413, 2017 Jun.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tow new arylalkenyl α,ß-unsaturated δ-lactones named cryptoconcatones K (1) and L (2) were obtained from the leaves and twigs of Cryptocarya concinna. Their structures were established on the basis of spectroscopic data (MS, 1D and 2D NMR). Compounds 1 and 2 showed cytotoxic activities with IC values of 4.5 and 3.9 µM against Huh7 cancer cell line, respectively.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Cryptocarya/química
Lactonas/isolamento & purificação
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Seres Humanos
Lactonas/química
Lactonas/farmacologia
Espectroscopia de Ressonância Magnética
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Lactones)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1255886


  4 / 47 MEDLINE  
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[PMID]:28852722
[Au] Autor:Hamza MF; Shaik S; Moodley R
[Ad] Endereço:School of Chemistry and Physics, University of Kwazulu Natal, Westville, Durban,4000, South Africa.
[Ti] Título:PHYTOCHEMICAL, ELEMENTAL AND BIOTECHNOLOGICAL STUDY OF .
[So] Source:Afr J Tradit Complement Altern Med;13(4):74-80, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Existing populations of (Lauraceae) are rapidly declining as a consequence of their substitutive use for . The uncontrolled and excessive removal of the bark and roots of this species has led to the death of many of these plants and may eventually result in its depletion in the natural habitat. MATERIALS AND METHODS: The secondary metabolites from the leaves and fruits of were extracted using solvents of various polarities, isolated using column chromatography and identified using spectroscopic techniques. The free radical scavenging activity (antioxidant capacity) of selected phytocompounds at varied concentrations was determined by the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. A propagation study of the species was also conducted. RESULTS: The compounds isolated from the plant were the novel compound, α-pyrone (5-hexyltetrahydro-2H-pyran-2-one) and known compounds quercetin-3- -rhamnoside, ß-sitosterol, copaene and nerolidol. The radical scavenging activity of the isolated compounds indicated moderate to good anti-oxidant activity. Treatment of explants with BAP: NAA at 1.0:0.01 mg L produced the highest percentage of shoots (94%) and longest shoot length (8.06 mm). CONCLUSION: This study validates the ethno-medicinal use of the plant and supports the replacement of bark and roots by leaves and fruits for the management and conservation of this declining plant species. The benefits of consuming the fruits are two-fold as they can also contribute to the recommended dietary allowances of most essential elements for the majority of individuals.
[Mh] Termos MeSH primário: Cryptocarya/química
Compostos Fitoquímicos/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/metabolismo
Frutas/química
Frutas/metabolismo
Seres Humanos
Extratos Vegetais/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i4.11


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[PMID]:27534124
[Au] Autor:Saidi N; Morita H; Litaudon M; Nafiah MA; Awang K; Mustanir
[Ti] Título:New Phenyl Propanoids from Cryptocarya bracteolata.
[So] Source:Nat Prod Commun;11(6):815-6, 2016 Jun.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two new phenyl propanoids were extracted from the bark of Cryptocarya bracteolate Gamb., ethyl 3-(2'-hydroxy-3',4',5'-trimethoxyphenyl) propanoate (1) and ethyl 3-(2'-glucosyl-3',4',5'-trimethoxyphenyl)propanoate (2), together with seven known alkaloids, (+)-lirioferine (3), (+)-bracteoline (4), (+)-reticuline (5), (+)-reticulineN-oxide (6), (-)-norargemonine (7), (+)-bisnorargemonine (8) and atherolin (9). The structures of compounds were established through several spectroscopic methods; 1D and 2D-NMR, UV, IR and MS.
[Mh] Termos MeSH primário: Alcaloides/química
Cryptocarya/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Casca de Planta
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Plant Extracts)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160818
[Lr] Data última revisão:
160818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE


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[PMID]:27492195
[Au] Autor:Wan Othman WNN; Liew SY; Khaw KY; Murugaiyah V; Litaudon M; Awang K
[Ad] Endereço:Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
[Ti] Título:Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).
[So] Source:Bioorg Med Chem;24(18):4464-4469, 2016 Sep 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alzheimer's disease is the most common form of dementia among older adults. Acetylcholinesterase and butyrylcholinesterase are two enzymes involved in the breaking down of the neurotransmitter acetylcholine. Inhibitors for these enzymes have potential to prolong the availability of acetylcholine. Hence, the search for such inhibitors especially from natural products is needed in developing potential drugs for Alzheimer's disease. The present study investigates the cholinesterase inhibitory activity of compounds isolated from three Cryptocarya species towards acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Nine alkaloids were isolated; (+)-nornantenine 1, (-)-desmethylsecoantofine 2, (+)-oridine 3, (+)-laurotetanine 4 from the leaves of Cryptocarya densiflora BI., atherosperminine 5, (+)-N-methylisococlaurine 6, (+)-N-methyllaurotetanine 7 from the bark of Cryptocarya infectoria Miq., 2-methoxyatherosperminine 8 and (+)-reticuline 9 from the bark of Cryptocarya griffithiana Wight. In general, most of the alkaloids showed higher inhibition towards BChE as compared to AChE. The phenanthrene type alkaloid; 2-methoxyatherosperminine 8, exhibited the most potent inhibition against BChE with IC50 value of 3.95µM. Analysis of the Lineweaver-Burk (LB) plot of BChE activity over a range of substrate concentration suggested that 2-methoxyatherosperminine 8 exhibited mixed-mode inhibition with an inhibition constant (Ki) of 6.72µM. Molecular docking studies revealed that 2-methoxyatherosperminine 8 docked well at the choline binding site and catalytic triad of hBChE (butyrylcholinesterase from Homo sapiens); hydrogen bonding with Tyr 128 and His 438 residues respectively.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Inibidores da Colinesterase/farmacologia
Isoquinolinas/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/efeitos dos fármacos
Acetilcolinesterase/metabolismo
Alcaloides/química
Butirilcolinesterase/efeitos dos fármacos
Butirilcolinesterase/metabolismo
Inibidores da Colinesterase/química
Cryptocarya/química
Seres Humanos
Concentração Inibidora 50
Isoquinolinas/química
Cinética
Simulação de Acoplamento Molecular
Análise Espectral/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Cholinesterase Inhibitors); 0 (Isoquinolines); 0 (Plant Extracts); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE


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[PMID]:27032214
[Au] Autor:Brophy JJ; Forster PI; Goldsack RJ
[Ti] Título:Coconut Laurels: The Leaf Essential Oils from Four Endemic Australian Cryptocarya Species: C. bellendenkerana, C. cocosoides, C. cunninghamii and C. lividula (Lauraceae).
[So] Source:Nat Prod Commun;11(2):255-8, 2016 Feb.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The leaf oils of four species of Cryptocarya, endemic to Australia, were examined. These species are known colloquially as 'coconut laurels' due to the purported distinctive aroma from the crushed foliage. C. cocosoides produced an oil in which bicyclogermacrene (3-26%), spathulenol (16-47%), massoia lactone (6-pentyl-5,6-dihydro-2H-pyran-2-one) (11-15%), (6-heptyl-5,6-dihydro-2H-pyran-2-one (0.3-3%) and benzyl benzoate (0.2-5%) were the principal components. C. cunninghamii showed a second chemotype to that previously published, with benzyl benzoate (80.2%) being the principal component. C. bellendenkerana gave a leaf oil in which the major components were the terpenes limonene (8.3%), ß-phellandrene (11.8%) and viridiflorene (9.1%). The principal components of the leaf oil of C. lividula were bicyclogermacrene (26.1%), spathulenol (21.1%) and ß-eudesmol (6.1%). Benzaldehyde and acetophenone were both present in amounts of less than 0.7%. Only C. cocosoides and C. cunninghamii have been found to have a 'coconut' aroma mainly due to the presence of massoia lactone and homologues.
[Mh] Termos MeSH primário: Cryptocarya/química
Cryptocarya/classificação
Óleos Voláteis/química
Folhas de Planta/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Austrália
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160401
[Lr] Data última revisão:
160401
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE


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[PMID]:26955958
[Au] Autor:Chang HS; Tang JY; Yen CY; Huang HW; Wu CY; Chung YA; Wang HR; Chen IS; Huang MY; Chang HW
[Ad] Endereço:Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan. hschang@kmu.edu.tw.
[Ti] Título:Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage.
[So] Source:BMC Complement Altern Med;16:94, 2016 Mar 08.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cryptocarya-derived crude extracts and their compounds have been reported to have an antiproliferation effect on several types of cancers but their impact on oral cancer is less well understood. METHODS: We examined the cell proliferation effect and mechanism of C. concinna-derived cryptocaryone (CPC) on oral cancer cells in terms of cell viability, apoptosis, reactive oxygen species (ROS), mitochondrial depolarization, and DNA damage. RESULTS: We found that CPC dose-responsively reduced cell viability of two types of oral cancer cells (Ca9-22 and CAL 27) in MTS assay. The CPC-induced dose-responsive apoptosis effects on Ca9-22 cells were confirmed by flow cytometry-based sub-G1 accumulation, annexin V staining, and pancaspase analyses. For oral cancer Ca9-22 cells, CPC also induced oxidative stress responses in terms of ROS generation and mitochondrial depolarization. Moreover, γH2AX flow cytometry showed DNA damage in CPC-treated Ca9-22 cells. CPC-induced cell responses in terms of cell viability, apoptosis, oxidative stress, and DNA damage were rescued by N-acetylcysteine pretreatment, suggesting that oxidative stress plays an important role in CPC-induced death of oral cancer cells. CONCLUSIONS: CPC is a potential ROS-mediated natural product for anti-oral cancer therapy.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Cryptocarya/química
Neoplasias Bucais/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Pironas/uso terapêutico
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Apoptose
Linhagem Celular Tumoral
Proliferação Celular
Dano ao DNA
Seres Humanos
Estresse Oxidativo
Extratos Vegetais/farmacologia
Pironas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Pyrones); 0 (cryptocaryone)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160311
[Lr] Data última revisão:
160311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1073-5


  9 / 47 MEDLINE  
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[PMID]:26887975
[Au] Autor:Chang HW; Tang JY; Yen CY; Chang HS; Huang HW; Chung YA; Chen IS; Huang MY
[Ad] Endereço:a Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University , Kaohsiung , Taiwan ;
[Ti] Título:Synergistic anti-oral cancer effects of UVC and methanolic extracts of Cryptocarya concinna roots via apoptosis, oxidative stress and DNA damage.
[So] Source:Int J Radiat Biol;92(5):263-72, 2016 05.
[Is] ISSN:1362-3095
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Purpose Radiation combined with natural products may improve the radiosensitivity of cancer cells. This study investigated the potential of a combined modality treatment with Ultraviolet C (UVC; wavelength range 200-280 nm) and our previously identified anti-oral cancer agent (methanolic extracts of Cryptocarya concinna roots; MECCrt) in oral cancer cells. Materials and methods The mechanism of the possible synergy of UVC and MECCrt was explored in terms of cell viability, cell cycle, apoptosis, reactive oxygen species (ROS), mitochondrial membrane potential (MitoMP), and DNA damage analyses. Results In cell viability (%) at 24 h treatment, the low doses of UVC (14 J/m(2)) and MECCrt (10 µg/ml) resulted in slight damage to human oral cancer Ca9-22 cells (83.2 and 80.4) but was less harmful to human oral normal HGF-1 cells (93.4 and 91.8, respectively). The combined treatment of UVC and MECCrt (UVC/MECCrt) had a lower viability (54.5%) than UVC or MECCrt alone in Ca9-22 cells but no showed significant change in HGF-1 cells. In Ca9-22 cells, the expression of flow cytometry-based apoptosis (sub-G1 phase, annexin V, and pancaspase assays) was significantly higher in UVC/MECCrt than in UVC or MECCrt alone (p < 0.0001). Using flow cytometry, intracellular ROS levels of UVC/MECCrt and MECCrt alone were higher than for UVC alone. MitoMP change and H2A histone family member X (γH2AX; H2AFX)-based DNA damage were synergistically inhibited and induced by MECCrt/UVC compared to its single treatment in Ca9-22 cells, respectively. Conclusion UVC plus MECCrt treatment had selective killing and synergistic anti-proliferative effects against oral cancer cells involving apoptosis, oxidative stress, and DNA damage. This combination therapy appears to have a great clinical potential against oral cancer cells.
[Mh] Termos MeSH primário: Cryptocarya/química
Dano ao DNA
Neoplasias Bucais/fisiopatologia
Neoplasias Bucais/terapia
Extratos Vegetais/química
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Antineoplásicos/administração & dosagem
Apoptose/efeitos dos fármacos
Apoptose/efeitos da radiação
Linhagem Celular Tumoral
Quimiorradioterapia/métodos
Relação Dose-Resposta a Droga
Relação Dose-Resposta à Radiação
Seres Humanos
Metanol/química
Neoplasias Bucais/patologia
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/efeitos da radiação
Extratos Vegetais/administração & dosagem
Tolerância a Radiação/efeitos dos fármacos
Dosagem Radioterapêutica
Espécies Reativas de Oxigênio/metabolismo
Resultado do Tratamento
Hipóxia Tumoral/efeitos dos fármacos
Hipóxia Tumoral/efeitos da radiação
Terapia Ultravioleta/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); 0 (Reactive Oxygen Species); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:160219
[St] Status:MEDLINE
[do] DOI:10.3109/09553002.2016.1145753


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[PMID]:26765353
[Au] Autor:Rolli E; Marieschi M; Maietti S; Guerrini A; Grandini A; Sacchetti G; Bruni R
[Ad] Endereço:Dipartimento di Bioscienze, Università degli Studi di Parma, Via G.P. Usberti 11/a, IT-43134 Parma.
[Ti] Título:Phytotoxic Effects and Phytochemical Fingerprinting of Hydrodistilled Oil, Enriched Fractions, and Isolated Compounds Obtained from Cryptocarya massoy (Oken) Kosterm. Bark.
[So] Source:Chem Biodivers;13(1):66-76, 2016 Jan.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The hydrodistilled oil of Cryptocarya massoy bark was characterized by GC-FID and GC/MS analyses, allowing the identification of unusual C10 massoia lactone (3, 56.2%), C12 massoia lactone (4, 16.5%), benzyl benzoate (1, 12.7%), C8 massoia lactone (3.4%), δ-decalactone (5, 1.5%), and benzyl salicylate (2, 1.8%) as main constituents. The phytotoxic activities of the oil, three enriched fractions (lactone-rich, ester-rich, and sesquiterpene-rich), and four constituents (compounds 1, 2, 5, and δ-dodecalactone (6)) against Lycopersicon esculentum and Cucumis sativus seeds and seedlings were screened. At a concentration of 1000 µl/l, the essential oil and the massoia lactone-rich fraction caused a complete inhibition of the germination of both seeds, and, when applied on tomato plantlets, they induced an 85 and 100% dieback, respectively. These performances exceeded those of the well-known phytotoxic essential oils of Syzygium aromaticum and Cymbopogon citratus, already used in commercial products for the weed and pest management. The same substances were also evaluated against four phytopathogenic bacteria and ten phytopathogenic fungi, providing EC50 values against the most susceptible strains in the 100-500 µl/l range for the essential oil and in the 10-50 µl/l range for compound 6 and the lactone-rich fraction. The phytotoxic behavior was related mainly to massoia lactones and benzyl esters, while a greater amount of 6 may infer a good activity against some phytopathogenic fungi. Further investigations of these secondary metabolites are warranted, to evaluate their use as natural herbicides.
[Mh] Termos MeSH primário: Antibacterianos/química
Antibacterianos/farmacologia
Antifúngicos/química
Antifúngicos/farmacologia
Bactérias/efeitos dos fármacos
Cryptocarya/química
Fungos/efeitos dos fármacos
Óleos Vegetais/farmacologia
Sementes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Antibacterianos/toxicidade
Antifúngicos/isolamento & purificação
Antifúngicos/toxicidade
Cucumis sativus/efeitos dos fármacos
Cucumis sativus/crescimento & desenvolvimento
Relação Dose-Resposta a Droga
Lycopersicon esculentum/efeitos dos fármacos
Lycopersicon esculentum/crescimento & desenvolvimento
Testes de Sensibilidade Microbiana
Estrutura Molecular
Casca de Planta/química
Óleos Vegetais/química
Óleos Vegetais/isolamento & purificação
Sementes/crescimento & desenvolvimento
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Plant Oils)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160115
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201500010



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