Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.595.400.399 [Categoria DeCS]
Referências encontradas : 130 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 13 ir para página                         

  1 / 130 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28487896
[Au] Autor:Al-Haidari RA; Shaaban MI; Ibrahim SRM; Mohamed GA
[Ad] Endereço:Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia.
[Ti] Título:ANTI-QUORUM SENSING ACTIVITY OF SOME MEDICINAL PLANTS.
[So] Source:Afr J Tradit Complement Altern Med;13(5):67-71, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Quorum sensing is the key regulator of virulence factors of such as biofilm formation, motility, productions of proteases, hemolysin, pyocyanin, and toxins. The aim of this study was to explore the effect of the extracts from some medicinal plants on quorum sensing and related virulence factors of . MATERIAL AND METHODS: Quorum sensing inhibitory (OSI) effect of the alcohol extracts of 20 medicinal plants was evaluated by reporter using agar cup diffusion method. The efficient QSI extracts were tested for their activity against biofilm synthesis, motility, and synthesis of pyocyanin from PA14. RESULTS: The extracts of , and exhibited potent quorum quenching effect. On the other hand, and extracts showed lower QSI activity. These extracts exhibited significant elimination of pyocyanin formation and biofilm development of PA14. In addition, they significantly inhibited twitching and swimming motilities of PA14. CONCLUSION: This study illustrated, for the first time, the importance of , and as quorum sensing inhibitors and virulence suppressors of . Thus, these plants could provide a natural source for the elimination of pathogenesis.
[Mh] Termos MeSH primário: Magnoliopsida/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
Pseudomonas aeruginosa/efeitos dos fármacos
Percepção de Quorum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Camellia sinensis/química
Chromobacterium/patogenicidade
Coriandrum/química
Elettaria/química
Laurus/química
Cebolas/química
Pseudomonas aeruginosa/patogenicidade
Fatores de Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Virulence Factors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i5.10


  2 / 130 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27788479
[Au] Autor:Vijayakumar S; Vaseeharan B; Malaikozhundan B; Shobiya M
[Ad] Endereço:Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechnology in Animal Health Lab, Department of Animal Health and Management, Alagappa University, Karaikudi-630004, Tamil Nadu, India.
[Ti] Título:Laurus nobilis leaf extract mediated green synthesis of ZnO nanoparticles: Characterization and biomedical applications.
[So] Source:Biomed Pharmacother;84:1213-1222, 2016 Dec.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The present study reports the green synthesis of zinc oxide nanoparticles using the aqueous leaf extract of Laurus nobilis (Ln-ZnO NPs) by co-precipitation method. The synthesized Ln-ZnO NPs were characterized by UV-Vis spectroscopy, FTIR, XRD, TEM, SEM and EDX. Ln-ZnO NPs were crystalline in nature, flower like and have hexagonal wurtzite structure with a mean particle size of 47.27nm. The antibacterial activity of Ln-ZnO NPs was greater against Gram positive (Staphylococcus aureus) bacteria than Gram negative (Pseudomonas aeruginosa) bacteria. The zone of inhibition against S. aureus was 11.4, 12.6 and 14.2mm at 25, 50 and 75µgmL . The zone of inhibition against P. aeruginosa was 9.8, 10.2 and 11.3mm at 25, 50 and 75µgmL . The light and confocal laser scanning microscopic images evidenced that Ln-ZnO NPs effectively inhibited the biofilm growth of S. aureus and P. aeruginosa at 75µgmL . The cytotoxicity studies revealed that Ln-ZnO NPs showed no effect on normal murine RAW264.7 macrophage cells. On the other hand, Ln-ZnO NPs were effective in inhibiting the viability of human A549 lung cancer cells at higher concentrations of 80µgmL . The morphological changes in the Ln-ZnO NPs treated A549 lung cancer cells were observed under phase contrast microscope.
[Mh] Termos MeSH primário: Tecnologia Biomédica/métodos
Química Verde/métodos
Laurus/química
Nanopartículas Metálicas/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Óxido de Zinco/química
[Mh] Termos MeSH secundário: Células A549
Animais
Antibacterianos/farmacologia
Antineoplásicos/farmacologia
Biofilmes/efeitos dos fármacos
Forma Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Camundongos
Testes de Sensibilidade Microbiana
Células RAW 264.7
Espectrometria por Raios X
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents); 0 (Plant Extracts); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE


  3 / 130 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27782086
[Au] Autor:Snuossi M; Trabelsi N; Ben Taleb S; Dehmeni A; Flamini G; De Feo V
[Ad] Endereço:Laboratoire de Traitement et Valorisation des Rejets Hydriques (LR 15 CERTEO5), Technopole de Borj-Cédria, BP 273, Soliman 8020, Tunisie. snmejdi@yahoo.fr.
[Ti] Título:Laurus nobilis, Zingiber officinale and Anethum graveolens Essential Oils: Composition, Antioxidant and Antibacterial Activities against Bacteria Isolated from Fish and Shellfish.
[So] Source:Molecules;21(10), 2016 Oct 22.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Several bacterial strains were isolated from wild and reared fish and shellfish. The identification of these strains showed the dominance of the species in all seafood samples, followed by spp., , , , and . The isolates were studied for their ability to produce exoenzymes and biofilms. The chemical composition of the essential oils from leaves, rhizomes and aerial parts was studied by GC and GC/MS. The essential oils' antioxidant and antibacterial activities against the isolated microorganisms were studied. Low concentrations of the three essential oils were needed to inhibit the growth of the selected bacteria and the lowest MBCs values were obtained for the laurel essential oil. The selected essential oils can be used as a good natural preservative in fish food due to their antioxidant and antibacterial activities.
[Mh] Termos MeSH primário: Peixes/microbiologia
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Óleos Vegetais/química
Óleos Vegetais/farmacologia
Frutos do Mar/microbiologia
[Mh] Termos MeSH secundário: Anethum graveolens/química
Animais
Antibacterianos/química
Antibacterianos/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Bactérias/classificação
Bactérias/efeitos dos fármacos
Bactérias/isolamento & purificação
Biofilmes/efeitos dos fármacos
Gengibre/química
Laurus/química
Testes de Sensibilidade Microbiana
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161027
[St] Status:MEDLINE


  4 / 130 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27390352
[Au] Autor:Betzin A; Thiv M; Koch MA
[Ad] Endereço:Department of Plant Systematics and Biodiversity, Centre for Organismal Studies (COS) Heidelberg, Heidelberg University, D-69120 Heidelberg, Germany.
[Ti] Título:Diversity hotspots of the laurel forest on Tenerife, Canary Islands: a phylogeographic study of Laurus and Ixanthus.
[So] Source:Ann Bot;118(3):495-510, 2016 Sep.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Macaronesian laurel forest is among the worldwide hotspots of threatened biodiversity. With increasing evidence that woodland composition on the Canary Islands changed dramatically during the last few thousand years, the aim of this study was to find evidence for substantial recent population dynamics of two representative species from laurel forest. METHODS: Amplified fragment length polymorphism (AFLP) was used to evaluate fine-scaled genetic variation of the paradigmatic tree Laurus novocanariensis (Lauraceae) and a long-lived herbaceous gentian from core laurel forest, Ixanthus viscosus (Gentianaceae), on Tenerife. Bioclimatic variables were analysed to study the respective climate niches. A chloroplast DNA screening was performed to evaluate additional genetic variation. KEY RESULTS: Genetic diversity of the laurel tree showed severe geographic partitioning. On Tenerife, fine-scaled Bayesian clustering of genetic variation revealed a western and an eastern gene pool, separated by a zone of high admixture and with a third major gene pool. Compared with genetic clusters found on the other Canary Islands, the East-West differentiation on Tenerife seems to be more recent than differentiation between islands. This is substantiated by the finding of extremly low levels of chloroplast DNA-based polymorphisms. Ixanthus showed no geographic structuring of genetic variation. CONCLUSIONS: Genetic data from Tenerife indicate contemporary gene flow and dispersal on a micro/local scale rather than reflecting an old and relic woodland history. In particular for Laurus, it is shown that this species occupies a broad bioclimatic niche. This is not correlated with its respective distribution of genetic variation, therefore indicating its large potential for contemporary rapid and effective colonization. Ixanthus is more specialized to humid conditions and is mostly found in the natural Monteverde húmedo vegetation types, but even for this species indications for long-term persistence in the respective bioclimatically differentiated regions was not find.
[Mh] Termos MeSH primário: Variação Genética
Gentianaceae/genética
Laurus/genética
[Mh] Termos MeSH secundário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Teorema de Bayes
DNA de Cloroplastos/genética
Florestas
Fluxo Gênico
Filogeografia
Polimorfismo Genético
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcw124


  5 / 130 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25749238
[Au] Autor:Bower A; Marquez S; de Mejia EG
[Ad] Endereço:a Division of Nutritional Sciences, Department of Food Science and Human Nutrition , University of Illinois Urbana-Champaign , Urbana , Illinois USA.
[Ti] Título:The Health Benefits of Selected Culinary Herbs and Spices Found in the Traditional Mediterranean Diet.
[So] Source:Crit Rev Food Sci Nutr;56(16):2728-46, 2016 Dec 09.
[Is] ISSN:1549-7852
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Mediterranean diet is considered one of the healthiest diets in the world. This is often attributed to low saturated fat consumption, moderate wine consumption, and high vegetable consumption. However, herbs and spices associated with these diets may also play an important role in the quality of this diet. This review summarizes the most recent research regarding the anti-diabetic, anti-inflammatory, anti-hyperlipidemic and anti-hypertensive properties of this collection of culinary species. Additionally, this review briefly summarizes studies performed on lesser known herbs from around the world, with the goal of identifying new culinary species that may be useful in the treatment or prevention of diseases.
[Mh] Termos MeSH primário: Dieta Mediterrânea
Especiarias/análise
[Mh] Termos MeSH secundário: Anethum graveolens/química
Animais
Anti-Inflamatórios/análise
Anti-Inflamatórios/farmacologia
Anti-Hipertensivos/análise
Anti-Hipertensivos/farmacologia
Artemisia/química
Chalconas/análise
Coriandrum/química
Cuminum/química
Modelos Animais de Doenças
Flavonoides/análise
Foeniculum/química
Seres Humanos
Hidroxibenzoatos/análise
Hipoglicemiantes/análise
Hipoglicemiantes/farmacologia
Hipolipemiantes/análise
Hipolipemiantes/farmacologia
Laurus/química
Ocimum basilicum/química
Origanum/química
Petroselinum/química
Plantas Medicinais/química
Rosmarinus/química
Salvia officinalis/química
Thymus (Planta)/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antihypertensive Agents); 0 (Chalcones); 0 (Flavonoids); 0 (Hydroxybenzoates); 0 (Hypoglycemic Agents); 0 (Hypolipidemic Agents); 29656-58-4 (phenolic acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150310
[St] Status:MEDLINE
[do] DOI:10.1080/10408398.2013.805713


  6 / 130 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26359684
[Au] Autor:Yahyaa M; Berim A; Isaacson T; Marzouk S; Bar E; Davidovich-Rikanati R; Lewinsohn E; Ibdah M
[Ad] Endereço:NeweYaar Research Center, Agriculture Research Organization , P.O. Box 1021, Ramat Yishay 30095, Israel.
[Ti] Título:Isolation and Functional Characterization of Carotenoid Cleavage Dioxygenase-1 from Laurus nobilis L. (Bay Laurel) Fruits.
[So] Source:J Agric Food Chem;63(37):8275-82, 2015 Sep 23.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bay laurel (Laurus nobilis L.) is an agriculturally important tree used in food, drugs, and the cosmetics industry. Many of the health beneficial properties of bay laurel are due to volatile terpene metabolites that they contain, including various norisoprenoids. Despite their importance, little is known about the norisoprenoid biosynthesis in Laurus nobilis fruits. We found that the volatile norisoprenoids 6-methyl-5-hepten-2-one, pseudoionone, and ß-ionone accumulated in Laurus nobilis fruits in a pattern reflecting their carotenoid content. A full-length cDNA encoding a potential carotenoid cleavage dioxygenase (LnCCD1) was isolated. The LnCCD1 gene was overexpressed in Escherichia coli, and recombinant protein was assayed for its cleavage activity with an array of carotenoid substrates. The LnCCD1 protein was able to cleave a variety of carotenoids at the 9,10 (9',10') and 5,6 (5',6') positions to produce 6-methyl-5-hepten-2-one, pseudoionone, ß-ionone, and α-ionone. Our results suggest a role for LnCCD1 in Laurus nobilis fruit flavor biosynthesis.
[Mh] Termos MeSH primário: Dioxigenases/isolamento & purificação
Dioxigenases/metabolismo
Frutas/enzimologia
Laurus/enzimologia
[Mh] Termos MeSH secundário: Carotenoides/metabolismo
DNA Complementar/genética
DNA Complementar/isolamento & purificação
Dioxigenases/genética
Escherichia coli/metabolismo
Frutas/química
Expressão Gênica
Norisoprenoides/análise
Norisoprenoides/biossíntese
Reação em Cadeia da Polimerase em Tempo Real
Proteínas Recombinantes/metabolismo
Paladar
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (Norisoprenoids); 0 (Recombinant Proteins); 36-88-4 (Carotenoids); EC 1.13.11.- (Dioxygenases); EC 1.13.11.- (carotenoid cleavage dioxygenase 1)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150923
[Lr] Data última revisão:
150923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150912
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b02941


  7 / 130 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26203884
[Au] Autor:Schelkle B; Snellgrove D; Jones LL; Cable J
[Ad] Endereço:School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
[Ti] Título:Efficacy of commercially available products against Gyrodactylus turnbulli infections on guppies Poecilia reticulata.
[So] Source:Dis Aquat Organ;115(2):129-37, 2015 Jul 23.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The demand for ornamental fish has led to a steep rise in aquaculture for the hobbyist trade, promoting the emergence, persistence and spread of various infectious diseases. Complete control of disease outbreaks with antibiotics and chemical-based medicines is rare, but plant compounds may herald potential alternatives effective against a range of pathogens. Melafix® and Pimafix® are formulated with the essential oils cajuput (Melaleuca cajuputi) and West Indian bay (Pimenta racemosa) and are marketed against bacterial and fungal infections, respectively. Previous experiments showed high efficacy of emulsified cajuput oil against gyrodactylids; the current study tested Melafix® and Pimafix® and their individual compounds against Gyrodactylus turnbulli infecting the guppies Poecilia reticulata. In particular, a combination treatment of Melafix® and Pimafix® was highly effective at reducing in vitro survival of parasites from 15 to 2 h and eradicating 95% of gyrodactylids in vivo. The unexpected high efficacy of this combination treatment is likely explained by the high content of terpenes and phenol propanoids in the cajuput and West Indian bay oils, as well as the anti-helminthic properties of the emulsifier Crovol PK 70. Hence, Melafix® and Pimafix® effectively reduce gyrodactylid burdens on fish, increasing the chances of efficient disease control in ornamental fish.
[Mh] Termos MeSH primário: Antiparasitários/uso terapêutico
Doenças dos Peixes/parasitologia
Óleos Vegetais/uso terapêutico
Poecilia
Infecções por Trematódeos/veterinária
[Mh] Termos MeSH secundário: Animais
Antinematódeos/uso terapêutico
Ectoparasitoses/tratamento farmacológico
Ectoparasitoses/veterinária
Doenças dos Peixes/tratamento farmacológico
Laurus/química
Levamisol/uso terapêutico
Melaleuca/química
Óleos Voláteis/química
Óleos Voláteis/uso terapêutico
Óleos Vegetais/química
Trematódeos/classificação
Infecções por Trematódeos/tratamento farmacológico
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antinematodal Agents); 0 (Antiparasitic Agents); 0 (Oils, Volatile); 0 (Plant Oils); 2880D3468G (Levamisole)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150724
[Lr] Data última revisão:
150724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150724
[St] Status:MEDLINE
[do] DOI:10.3354/dao02886


  8 / 130 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26157114
[Au] Autor:Yahyaa M; Matsuba Y; Brandt W; Doron-Faigenboim A; Bar E; McClain A; Davidovich-Rikanati R; Lewinsohn E; Pichersky E; Ibdah M
[Ad] Endereço:Newe Yaar Research Center, Agriculture Research Organization, Ramat Yishay 30095, Israel (M.Y., A.D.-F., E.B., R.D.-R., E.L., M.I.);Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 (Y.M., A.M., E.P.); andDepartment of Bioorganic Chemistry
[Ti] Título:Identification, Functional Characterization, and Evolution of Terpene Synthases from a Basal Dicot.
[So] Source:Plant Physiol;169(3):1683-97, 2015 Nov.
[Is] ISSN:1532-2548
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bay laurel (Laurus nobilis) is an agriculturally and economically important dioecious tree in the basal dicot family Lauraceae used in food and drugs and in the cosmetics industry. Bay leaves, with their abundant monoterpenes and sesquiterpenes, are used to impart flavor and aroma to food, and have also drawn attention in recent years because of their potential pharmaceutical applications. To identify terpene synthases (TPSs) involved in the production of these volatile terpenes, we performed RNA sequencing to profile the transcriptome of L. nobilis leaves. Bioinformatic analysis led to the identification of eight TPS complementary DNAs. We characterized the enzymes encoded by three of these complementary DNAs: a monoterpene synthase that belongs to the TPS-b clade catalyzes the formation of mostly 1,8-cineole; a sesquiterpene synthase belonging to the TPS-a clade catalyzes the formation of mainly cadinenes; and a diterpene synthase of the TPS-e/f clade catalyzes the formation of geranyllinalool. Comparison of the sequences of these three TPSs indicated that the TPS-a and TPS-b clades of the TPS gene family evolved early in the evolution of the angiosperm lineage, and that geranyllinalool synthase activity is the likely ancestral function in angiosperms of genes belonging to an ancient TPS-e/f subclade that diverged from the kaurene synthase gene lineages before the split of angiosperms and gymnosperms.
[Mh] Termos MeSH primário: Alquil e Aril Transferases/genética
Laurus/enzimologia
Terpenos/metabolismo
[Mh] Termos MeSH secundário: Alquil e Aril Transferases/metabolismo
Sequência de Bases
Cicloexanóis/metabolismo
DNA Complementar/genética
Evolução Molecular
Genes Reporter
Liases Intramoleculares/genética
Liases Intramoleculares/metabolismo
Laurus/química
Laurus/genética
Modelos Moleculares
Dados de Sequência Molecular
Monoterpenos/metabolismo
Filogenia
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
RNA de Plantas/química
RNA de Plantas/genética
Proteínas Recombinantes
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Cyclohexanols); 0 (DNA, Complementary); 0 (Monoterpenes); 0 (Plant Proteins); 0 (RNA, Plant); 0 (Recombinant Proteins); 0 (Terpenes); EC 2.5.- (Alkyl and Aryl Transferases); EC 2.5.1.- (terpene synthase); EC 5.5.- (Intramolecular Lyases); EC 5.5.- (pinene cyclase I); RV6J6604TK (eucalyptol)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150710
[St] Status:MEDLINE
[do] DOI:10.1104/pp.15.00930


  9 / 130 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26114728
[Au] Autor:Rodd AL; Ververis K; Sayakkarage D; Khan AW; Rafehi H; Ziemann M; Loveridge SJ; Lazarus R; Kerr C; Lockett T; El-Osta A; Karagiannis TC; Bennett LE
[Ad] Endereço:Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.
[Ti] Título:RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells.
[So] Source:Food Funct;6(8):2507-24, 2015 Aug.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anti-proliferative and pro-apoptotic effects of Bay leaf (Laurus nobilis) in mammalian cancer and HT-29 adenocarcinoma cells have been previously attributed to effects of polyphenolic and essential oil chemical species. Recently, we demonstrated differentiated growth-regulating effects of high (HFBL) versus low molecular mass (LFBL) aqueous fractions of bay leaf and now confirm by comparative effects on gene expression, that HFBL and LFBL suppress HT-29 growth by distinct mechanisms. Induction of intra-cellular lesions including DNA strand breakage by extra-cellular HFBL, invoked the hypothesis that iron-mediated reactive oxygen species with capacity to penetrate cell membrane, were responsible for HFBL-mediated effects, supported by equivalent effects of HFBL in combination with γ radiation. Activities of HFBL and LFBL were interpreted to reflect differentiated responses to iron-mediated reactive oxygen species (ROS), occurring either outside or inside cells. In the presence of LFBL, apoptotic death was relatively delayed compared with HFBL. ROS production by LFBL mediated p53-dependent apoptosis and recovery was suppressed by promoting G1/S phase arrest and failure of cellular tight junctions. In comparison, intra-cellular anti-oxidant protection exerted by LFBL was absent for extra-cellular HFBL (likely polysaccharide-rich), which potentiated more rapid apoptosis by producing DNA double strand breaks. Differentiated effects on expression of genes regulating ROS defense and chromatic condensation by LFBL versus HFBL, were observed. The results support ferrous iron in cell culture systems and potentially in vivo, can invoke different extra-cellular versus intra-cellular ROS-mediated chemistries, that may be regulated by exogenous, including dietary species.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Neoplasias Colorretais/fisiopatologia
Laurus/química
Extratos Vegetais/farmacologia
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Animais
Ciclo Celular/efeitos dos fármacos
Diferenciação Celular/efeitos dos fármacos
Neoplasias Colorretais/tratamento farmacológico
Neoplasias Colorretais/genética
Neoplasias Colorretais/metabolismo
Quebras de DNA de Cadeia Dupla/efeitos dos fármacos
Células HT29
Seres Humanos
Peso Molecular
Extratos Vegetais/química
Folhas de Planta/química
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150806
[Lr] Data última revisão:
150806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150627
[St] Status:MEDLINE
[do] DOI:10.1039/c5fo00467e


  10 / 130 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25976492
[Au] Autor:Vinha AF; Guido LF; Costa AS; Alves RC; Oliveira MB
[Ad] Endereço:REQUIMTE, LAQV/Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. beatoliv@ff.up.pt.
[Ti] Título:Monomeric and oligomeric flavan-3-ols and antioxidant activity of leaves from different Laurus sp.
[So] Source:Food Funct;6(6):1944-9, 2015 Jun.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The phenolic profile and antioxidant activity of three endemic Laurus sp. from Portugal were analysed. Dried leaves of L. nobilis L., L. azorica (Seub.) Franco, and L. novocanariensis Rivas Mart., Lousã, Fern. Prieto, E. Días, J. C. Costa & C. Aguiar, collected in the mainland and in the Azores and Madeira archipelagos, respectively, were used to prepare different extracts (aqueous, ethanolic and hydroalcoholic). They were studied regarding their DPPHË™ scavenging activity, total phenolic and flavonoid contents, and the main phenolic compounds were identified by HPLC-DAD-ESI-MS/MS. Total flavonoid contents were 30.1, 46.3, and 36.7 mg of epicatechin equivalents per g of sample (dry weight) for L. nobilis, L. azorica and L. novocanariensis, respectively. Epicatechin was the major compound, representing ∼12.1% of total flavan-3-ols in L. nobilis, ∼25.6% in L. azorica, and ∼19.9% in L. novocanariensis. Although all samples presented a similar phenolic profile, significant differences were observed in their total contents and antioxidant activity.
[Mh] Termos MeSH primário: Antioxidantes/química
Flavonoides/química
Laurus/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Antioxidantes/análise
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Açores
Catequina/análise
Catequina/química
Catequina/isolamento & purificação
Catequina/farmacologia
Cromatografia Líquida de Alta Pressão
Flavonoides/análise
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Depuradores de Radicais Livres/análise
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Peso Molecular
Fenóis/análise
Fenóis/química
Fenóis/isolamento & purificação
Fenóis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Portugal
Proantocianidinas/análise
Proantocianidinas/química
Proantocianidinas/isolamento & purificação
Proantocianidinas/farmacologia
Solventes/química
Especificidade da Espécie
Espectrometria de Massas por Ionização por Electrospray
Espectrofotometria Ultravioleta
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Phenols); 0 (Plant Extracts); 0 (Proanthocyanidins); 0 (Solvents); 35HDD3NRIE (flavan-3-ol); 8R1V1STN48 (Catechin)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150516
[St] Status:MEDLINE
[do] DOI:10.1039/c5fo00229j



página 1 de 13 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde