Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.595.400.587 [Categoria DeCS]
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[PMID]:28407959
[Au] Autor:Gontijo DC; Brandão GC; Gontijo PC; de Oliveira AB; Diaz MA; Fietto LG; Leite JP
[Ad] Endereço:Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais, MG, Brazil; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, MG, Brazil.
[Ti] Título:Identification of phenolic compounds and biologically related activities from Ocotea odorifera aqueous extract leaves.
[So] Source:Food Chem;230:618-626, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ocotea odorifera (Vell.) Rohwer is popularly used as food and flavoring. The aim of this study was to determine the chemical composition of the aqueous extract from O. odorifera leaves and evaluate the correlation of their phytochemical composition and biological activities. The antioxidant effect was determined by DPPH radical scavenging, ß-carotene-linoleic acid and lipid peroxidation assays; the antibacterial activity was evaluated by the hole plate and MIC techniques and the antimutagenic activity was evaluated by the Ames test. Identification of phytochemicals was performed by LC-ESI/MS and the correlation between the phytochemical composition of the extract and the evaluated activities. The results allowed the identification of 13 phenolic compounds in the extract that exhibited high antioxidant activity and moderate antibacterial and antimutagenic action. Statistical analyses showed correlation of the total phenolic content with biologically related activities. The phytochemical analyses, together with the biological results, support the popular use of O. odorifera.
[Mh] Termos MeSH primário: Flavonoides/química
Ocotea/química
Extratos Vegetais/química
Folhas de Planta/química
Taninos/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Compostos Fitoquímicos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Tannins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:27482860
[Au] Autor:Candido LP; Varela RM; Torres A; Molinillo JM; Gualtieri SC; Macías FA
[Ad] Endereço:Department of Botany, Federal University of São Carlos, Av. Rodovia Washington Luiz, Km 235, Monjolinho, CEP 13565-905, São Carlos, São Paulo, Brazil.
[Ti] Título:Evaluation of the Allelopathic Potential of Leaf, Stem, and Root Extracts of Ocotea pulchella Nees et Mart.
[So] Source:Chem Biodivers;13(8):1058-67, 2016 Aug.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Despite the increase in recent decades in herbicide research on the potential of native plants, current knowledge is considered to be low. Very few studies have been carried out on the chemical profile or the biological activity of the Brazilian savanna (Cerrado) species. In the study reported here, the allelopathic activity of AcOEt and MeOH extracts of leaves, stems, and roots from Ocotea pulchella Nees was evaluated. The extracts were assayed on etiolated wheat coleoptiles. The AcOEt leaf extract was the most active and this was tested on standard target species (STS). Lycopersicon esculentum and Lactuca sativa were the most sensitive species in this test. A total of eleven compounds have been isolated and characterized. Compounds 1, 2, 4, and 6 have not been identified previously from O. pulchella and ocoteol (9) is reported for the first time in the literature. Eight compounds were tested on wheat coleoptile growth, and spathulenol, benzyl salicylate, and benzyl benzoate showed the highest activities. These compounds showed inhibitory activity on L. esculentum. The values obtained correspond to the activity exhibited by the extract and these compounds may therefore be responsible for the allelopathic activity shown by O. pulchella.
[Mh] Termos MeSH primário: Lycopersicon esculentum/efeitos dos fármacos
Ocotea/química
Extratos Vegetais/farmacologia
Raízes de Plantas/química
Caules de Planta/química
Triticum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Brasil
Cotilédone/efeitos dos fármacos
Lycopersicon esculentum/crescimento & desenvolvimento
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Triticum/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201500501


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[PMID]:26897464
[Au] Autor:Marquele-Oliveira F; Torres EC; Barud Hda S; Zoccal KF; Faccioli LH; Hori JI; Berretta AA
[Ad] Endereço:Laboratório de Pesquisa, Desenvolvimento e Inovação, Apis Flora Indl. Coml. Ltda., Ribeirão Preto, SP, Brazil. Electronic address: fmarqueleoliveira@gmail.com.
[Ti] Título:Physicochemical characterization by AFM, FT-IR and DSC and biological assays of a promising antileishmania delivery system loaded with a natural Brazilian product.
[So] Source:J Pharm Biomed Anal;123:195-204, 2016 May 10.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The control and treatment of Leishmaniasis, a neglected and infectious disease affecting approximately 12 million people worldwide, are challenging. Leishmania parasites multiply intracellularly within macrophages located in deep skin and in visceral tissues, and the currently employed treatments for this disease are subject to significant drawbacks, such as resistance and toxicity. Thus, the search for new Leishmaniasis treatments is compulsory, and Ocotea duckei Vattimo, a plant-derived product from the biodiverse Brazilian flora, may be a promising new treatment for this disease. In this regard, the aim of this work was to develop and characterize a delivery system based on solid lipid nanoparticles (SLN) that contain the liposoluble lignan fraction (LF) of Ocotea duckei Vattimo, which targets the Leishmania phagolysosome of infected macrophages. LF-loaded SLNs were obtained via the hot microemulsion method, and their physical and chemical properties were comprehensively assessed using PCS, AFM, SEM, FT-IR, DSC, HPLC, kinetic drug release studies, and biological assays. The size of the developed delivery system was 218.85±14.2 nm, its zeta potential was -30 mV and its entrapment efficiency (EE%) was high (the EEs% of YAN [yangambin] and EPI-YAN [epi-yangambin] markers were 94.21±0.40% and 94.20±0.00%, respectively). Microscopy, FT-IR and DSC assays confirmed that the delivery system was nanosized and indicated a core-shell encapsulation model, which corroborated the measured kinetics of drug release. The total in vitro release rates of YAN and EPI-YAN in buffer (with sink conditions attained) were 29.6±8.3% and 34.3±8.9%, respectively, via diffusion through the cellulose acetate membrane of the SLN over a period of 4 h. After 24 h, the release rates of both markers reached approximately 45%, suggesting a sustained pattern of release. Mathematical modeling indicated that both markers, YAN and EPI-YAN, followed matrix diffusion-based release kinetics (Higuchi's model) with an estimated diffusion coefficient (D) of 1.3.10(-6) cm(2)/s. The LF-loaded SLNs were non-toxic to murine macrophages (20-80 µg mL(-1) range) and exerted a prominent anti-leishmanial effect (20 µg mL(-1)). These data suggest this new and well-characterized lipid nanoparticle delivery system safely and effectively kills Leishmania and warrants further clinical investigation.
[Mh] Termos MeSH primário: Antiparasitários/administração & dosagem
Antiparasitários/química
Produtos Biológicos/administração & dosagem
Produtos Biológicos/química
Leishmania/efeitos dos fármacos
Leishmaniose/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Bioensaio/métodos
Brasil
Química Farmacêutica/métodos
Difusão
Portadores de Fármacos/química
Sistemas de Liberação de Medicamentos/métodos
Cinética
Leishmaniose/parasitologia
Lignanas/administração & dosagem
Lignanas/química
Lipídeos/administração & dosagem
Lipídeos/química
Macrófagos/parasitologia
Camundongos
Camundongos Endogâmicos C57BL
Microscopia de Força Atômica/métodos
Nanopartículas/administração & dosagem
Nanopartículas/química
Ocotea/química
Tamanho da Partícula
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Pele/parasitologia
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Biological Products); 0 (Drug Carriers); 0 (Lignans); 0 (Lipids); 0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160222
[St] Status:MEDLINE


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[PMID]:25789338
[Au] Autor:Costa IF; Calixto SD; Heggdorne de Araujo M; Konno TU; Tinoco LW; Guimarães DO; Lasunskaia EB; Leal IR; Muzitano MF
[Ad] Endereço:Laboratório de Produtos Naturais (LaProN), Curso de Farmácia, Universidade Federal do Rio de Janeiro, Campus Macaé, Polo Novo Cavaleiro-IMMT, R. Aluísio da Silva Gomes 50, 27930-560 Macaé, RJ, Brazil.
[Ti] Título:Antimycobacterial and nitric oxide production inhibitory activities of Ocotea notata from Brazilian restinga.
[So] Source:ScientificWorldJournal;2015:947248, 2015.
[Is] ISSN:1537-744X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The genus Ocotea (Lauraceae) is distributed mainly in tropical and subtropical regions. Some species of this genus as O. puberula and O. quixos have been described in the literature, showing antibacterial activity. And Ocotea macrophylla showed anti-inflammatory activity with inhibition of COX-1, COX-2, and LOX-5. The purpose of this study was the phytochemical investigation of the plant species Ocotea notata from Restinga Jurubatiba National Park, Macaé, RJ, Brazil, and the search for antimycobacterial fractions and compounds. The crude extract was evaluated for antimycobacterial activity and presented 95.75 ± 2.53% of growth inhibition at 100 µg/mL. Then, it was subjected to a liquid-liquid partition and subsequently was chemically investigated by HPLC, revealing the major presence of flavonoids. In this process the partition fractions hexane, ethyl acetate, and butanol are shown to be promising in the antimycobacterial assay. In addition, ethyl acetate fraction was chromatographed and afforded two flavonoids identified by MS and NMR as afzelin and isoquercitrin. The isolated flavonoids afzelin and isoquercitrin were evaluated for their antimycobacterial activity and for their ability to inhibit NO production by macrophages stimulated by LPS; both flavonoids isoquercitrin (Acet22) and afzelin (Acet32) were able to inhibit the production of NO by macrophages. The calculated IC50 of Acet22 and Acet32 was 1.03 and 0.85 µg/mL, respectively.
[Mh] Termos MeSH primário: Antituberculosos/farmacologia
Óxido Nítrico/biossíntese
Ocotea/química
[Mh] Termos MeSH secundário: Animais
Brasil
Linhagem Celular
Cromatografia Líquida de Alta Pressão
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antitubercular Agents); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150320
[St] Status:MEDLINE
[do] DOI:10.1155/2015/947248


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[PMID]:25650896
[Au] Autor:Rakotondraibe LH; Graupner PR; Xiong Q; Olson M; Wiley JD; Krai P; Brodie PJ; Callmander MW; Rakotobe E; Ratovoson F; Rasamison VE; Cassera MB; Hahn DR; Kingston DG; Fotso S
[Ad] Endereço:†Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, United States.
[Ti] Título:Neolignans and other metabolites from Ocotea cymosa from the Madagascar rain forest and their biological activities.
[So] Source:J Nat Prod;78(3):431-40, 2015 Mar 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ten new neolignans including the 6'-oxo-8.1'-lignans cymosalignans A (1a), B (2), and C (3), an 8.O.6'-neolignan (4a), ococymosin (5a), didymochlaenone C (6a), and the bicyclo[3.2.1]octanoids 7-10 were isolated along with the known compounds 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan, 3,4,5,3'-tetramethoxy-1'-allyl-8.O.4'-neolignan, didymochlaenone B, virologin B, ocobullenone, and the unusual 2'-oxo-8.1'-lignan sibyllenone from the stems or bark of the Madagascan plant Ocotea cymosa. The new 8.O.6'-neolignan 4a, dihydrobenzofuranoid 5a, and the bicyclo[3.2.1]octanoid 7a had in vitro activity against Aedes aegypti, while the new compounds 5a, 7a, 8, and 10a and the known virolongin B (4b) and ocobullenone (10b) had antiplasmodial activity. We report herein the structure elucidation of the new compounds on the basis of spectroscopic evidence, including 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometry, and the biological activities of the new and known compounds.
[Mh] Termos MeSH primário: Inseticidas/isolamento & purificação
Inseticidas/farmacologia
Lignanas/isolamento & purificação
Ocotea/química
[Mh] Termos MeSH secundário: Animais
Ensaios de Seleção de Medicamentos Antitumorais
Feminino
Florestas
Seres Humanos
Inseticidas/química
Lignanas/química
Lignanas/farmacologia
Madagáscar
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Plasmodium falciparum/efeitos dos fármacos
Spodoptera/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Insecticides); 0 (Lignans); 0 (didymochlaenone B)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150205
[St] Status:MEDLINE
[do] DOI:10.1021/np5008153


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[PMID]:25061738
[Au] Autor:Martins EM; Martinelli G; Arbetman MP; Lamont RW; Simões-Araújo JL; Powell D; Ciampi-Guillardi M; Baldauf C; Quinet A; Galisa P; Shapcott A
[Ad] Endereço:Diretoria de Pesquisa, Instituto de Pesquisas Jardim Botânico do Rio de Janeiro, Rio de Janeiro, RJ, Brasil eline@cncflora.net.
[Ti] Título:Development and characterization of microsatellite loci for Ocotea species (Lauraceae) threatened with extinction.
[So] Source:Genet Mol Res;13(3):5138-42, 2014 Jul 07.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The Atlantic rainforest species Ocotea catharinensis, Ocotea odorifera, and Ocotea porosa have been extensively harvested in the past for timber and oil extraction and are currently listed as threatened due to overexploitation. To investigate the genetic diversity and population structure of these species, we developed 8 polymorphic microsatellite markers for O. odorifera from an enriched microsatellite library by using 2 dinucleotide repeats. The microsatellite markers were tested for cross-amplification in O. catharinensis and O. porosa. The average number of alleles per locus was 10.2, considering all loci over 2 populations of O. odorifera. Observed and expected heterozygosities for O. odorifera ranged from 0.39 to 0.93 and 0.41 to 0.92 across populations, respectively. Cross-amplification of all loci was successfully observed in O. catharinensis and O. porosa except 1 locus that was found to lack polymorphism in O. porosa. Combined probabilities of identity in the studied Ocotea species were very low ranging from 1.0 x 10-24 to 7.7 x 10-24. The probability of exclusion over all loci estimated for O. odorifera indicated a 99.9% chance of correctly excluding a random nonparent individual. The microsatellite markers described in this study have high information content and will be useful for further investigations on genetic diversity within these species and for subsequent conservation purposes.
[Mh] Termos MeSH primário: Espécies em Perigo de Extinção
Loci Gênicos
Repetições de Microssatélites
Ocotea/genética
[Mh] Termos MeSH secundário: Alelos
Conservação dos Recursos Naturais
Marcadores Genéticos
Variação Genética
Genética Populacional
Heterozigoto
Ocotea/classificação
Floresta Úmida
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140726
[Lr] Data última revisão:
140726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140726
[St] Status:MEDLINE
[do] DOI:10.4238/2014.July.7.6


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[PMID]:24274027
[Au] Autor:Leporatti ML; Pintore G; Foddai M; Chessa M; Piana A; Petretto GL; Masia MD; Mangano G; Nicoletti M
[Ad] Endereço:a Dip. di Biologia Ambientale , University of Rome "Sapienza" , P.le A. Moro 5, I-0185 Rome , Italy.
[Ti] Título:Chemical, biological, morphoanatomical and antimicrobial study of Ocotea puchury-major Mart.
[So] Source:Nat Prod Res;28(5):294-300, 2014.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ocotea puchury-major Mart. is a tree native to the Brazilian rain forest, where it is popularly known as puxurì. In local folk medicine the leaves are used for their sedative, gastroenteric and antireumatic properties. The morphoanatomical study determined those features useful in distinguishing this species from other closely related taxa. Chemical analysis was focused on the study of the volatile oil. Gas chromatography-mass spectrometry analyses indicated safrol as the main compound of the volatile oil (39%). The results confirm and authenticate the use of its leaves in folk medicine. Furthermore, safrol is economically important as the starting material for hemisynthesis of several products. The antimicrobial activity of the essential oil was studied which showed promising activity against environmental microorganisms as well as anti-inflammatory activity.
[Mh] Termos MeSH primário: Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Ocotea/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Inflamatórios/química
Brasil
Cromatografia Gasosa-Espectrometria de Massas
Medicina Tradicional
Óleos Voláteis/química
Folhas de Planta/química
Óleos Vegetais/química
Safrol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents); 0 (Oils, Volatile); 0 (Plant Oils); RSB34337V9 (Safrole)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140314
[Lr] Data última revisão:
140314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131127
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2013.858338


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[PMID]:23892138
[Au] Autor:Guterres Zda R; da Silva AF; Garcez WS; Garcez FR; Fernandes CA; Garcez FR
[Ad] Endereço:Universidade Estadual de Mato Grosso do Sul, Unidade Universitária de Mundo Novo - Grupo de Estudo de Ciências Ambientais e Educação (GEAMBE), BR 163 Km 20, 2, Mundo Novo, MS 79980-000, Brazil. Electronic address: zairaguterres@yahoo.com.br.
[Ti] Título:Mutagenicity and recombinagenicity of Ocotea acutifolia (Lauraceae) aporphinoid alkaloids.
[So] Source:Mutat Res;757(1):91-6, 2013 Sep 18.
[Is] ISSN:0027-5107
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The somatic mutation and recombination test (SMART) in wing cells of Drosophila melanogaster was used to test the mutagenic and recombinogenic activities of five aporphinoid alkaloids isolated from Ocotea acutifolia: thalicminine (1), (+)-dicentrine (2), (+)-ocoteine (3), (+)-6S-ocoteine N-oxide (4), and (+)-leucoxine (5). Third-stage larvae derived from the standard cross with wing cell markers mwh and/or flr(3) were treated chronically. The frequencies of mutant spots observed in marked heterozygous descendants revealed significant dose-dependent genotoxicity for alkaloids 1-4; compounds 1 and 2 were the most active. Alkaloids 1-4 also induced mitotic recombination. The presence of a methoxyl group at C-3 (as in compound 3) lowers its genotoxic effect relative to that of unsubstituted analogue 2, and the introduction of an N-oxide functionality (3 vs. 4) further reduces genotoxicity. The very planar conformation of oxo-aporphine alkaloid 1 may account for its higher genotoxicity vs. its less-planar analogues 3 and 4. As previously reported for (+)-dicentrine (2), alkaloids 1, 3, and 4 may also be DNA intercalating agents, interfering with the catalytic activity of topoisomerases.
[Mh] Termos MeSH primário: Alcaloides
Substâncias Intercalantes
Ocotea/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/farmacologia
Animais
DNA Topoisomerases/metabolismo
Drosophila melanogaster/efeitos dos fármacos
Drosophila melanogaster/genética
Substâncias Intercalantes/química
Substâncias Intercalantes/farmacologia
Larva/efeitos dos fármacos
Larva/genética
Mutagênese
Mutação/genética
Ocotea/genética
Recombinação Genética/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Intercalating Agents); EC 5.99.1.- (DNA Topoisomerases)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130925
[Lr] Data última revisão:
130925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130730
[St] Status:MEDLINE


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[PMID]:22847542
[Au] Autor:Wheelwright NT; Sinclair JP; Hochwender C; Janzen FJ
[Ad] Endereço:Department of Biology, Bowdoin College, Brunswick, Maine 04011, USA. nwheelwr@bowdoin.edu
[Ti] Título:Leaf size in three generations of a dioecious tropical tree, Ocotea tenera (Lauraceae): Sexual dimorphism and changes with age.
[So] Source:Am J Bot;99(8):1350-5, 2012 Aug.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: In dioecious species, selection should favor different leaf sizes in males and females whenever the sexes experience distinct environments or constraints such as different costs of reproduction. We took advantage of a long-term experimental study of Ocotea tenera (Lauraceae), a dioecious understory tree in Monteverde, Costa Rica, to explore leaf size differences between genders and age classes across generations. METHODS: We measured leaf size in adult trees in a natural population, in their adult F(1) offspring in two experimental populations, and in their F(2) offspring at the seedling stage. Individual trees were measured at various times over 20 yr. RESULTS: Leaves of female trees averaged 8% longer and 12% greater in area than those of males. Leaves were sexually dimorphic at reproductive maturity. Leaf size declined during the lifetime of most trees. Heritability estimates for leaf length were positive although not statistically significant (h(2) = 0.63, SE = 0.48, P = 0.095). CONCLUSIONS: We ruled out the ecological causation hypothesis for sexual dimorphism in leaf size because male and female trees co-occurred in the same habitats. Sexual dimorphism appeared not to result from genetic or phenotypic correlations with other traits such as height or flower size. Rather, females appear to compensate for higher costs of reproduction and diminished photosynthetic capacity by producing larger leaves. Additive genetic variance in leaf size, a prerequisite for an evolutionary response to selection for sexual dimorphism, was suggested by positive (although only marginally significant) heritability estimates.
[Mh] Termos MeSH primário: Ocotea/fisiologia
Folhas de Planta/fisiologia
Característica Quantitativa Herdável
Seleção Genética
[Mh] Termos MeSH secundário: Evolução Biológica
Costa Rica
Variação Genética
Ocotea/genética
Ocotea/crescimento & desenvolvimento
Fenótipo
Fotossíntese
Folhas de Planta/genética
Folhas de Planta/crescimento & desenvolvimento
Reprodução
Plântulas/genética
Plântulas/crescimento & desenvolvimento
Plântulas/fisiologia
Fatores de Tempo
Árvores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1308
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120801
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1200182


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[PMID]:22815198
[Au] Autor:Montrucchio DP; Miguel OG; Zanin SM; da Silva GA; Cardozo AM; Santos AR
[Ad] Endereço:Departamento de Farmácia, Setor de Ciências da Saúde, Universidade Federal do Paraná, Curitiba, PR, Brazil.
[Ti] Título:Antinociceptive effects of a chloroform extract and the alkaloid dicentrine isolated from fruits of Ocotea puberula.
[So] Source:Planta Med;78(14):1543-8, 2012 Sep.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The present work describes the chemical characterization of a chloroform fraction (CF) obtained from an extract of Ocotea puberula (Lauraceae) fruits, and preliminary antinociceptive analysis of CF and the alkaloid dicentrine, isolated from this fraction. CF (30-300 mg/kg, p. o.) caused dose-related inhibition of abdominal constrictions caused by acetic acid and also inhibited both phases of formalin-induced nociception. However, hexane or ethyl acetate fractions did not produce any effect. Antinociception caused by CF (100 mg/kg, p. o.) in the acetic acid test was not affected either by caffeine, an adenosine receptor antagonist, or by naloxone, an opioid receptor antagonist, and neither was associated with nonspecific effects such as muscle relaxation or sedation. Furthermore, dicentrine (30-300 mg/kg, p. o.) produced dose-related inhibition of acetic acid-induced pain without causing changes in the motor performance of mice. The results show, for the first time, that CF from Ocotea puberula fruits produced marked antinociception in different models of chemical pain, and this effect appears to be, at least in part, due to the presence of dicentrine. The mechanism by which CF and the alkaloid produced antinociception still remains unclear, but the adenosinergic or opioid system seems unlikely to be involved in this action.
[Mh] Termos MeSH primário: Analgésicos Opioides/farmacologia
Aporfinas/farmacologia
Ocotea/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Ácido Acético/farmacologia
Alcaloides/química
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Analgésicos Opioides/química
Analgésicos Opioides/isolamento & purificação
Animais
Aporfinas/química
Aporfinas/isolamento & purificação
Clorofórmio
Relação Dose-Resposta a Droga
Formaldeído/farmacologia
Frutas/química
Masculino
Camundongos
Estrutura Molecular
Dor Nociceptiva/induzido quimicamente
Dor/induzido quimicamente
Medição da Dor/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Analgesics, Opioid); 0 (Aporphines); 0 (Plant Extracts); 1HG84L3525 (Formaldehyde); 7V31YC746X (Chloroform); J2ZGT5M0N7 (dicentrine); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120721
[St] Status:MEDLINE



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