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Pesquisa : B01.650.940.800.575.912.250.595.600.500 [Categoria DeCS]
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[PMID]:28414230
[Au] Autor:Bakiri A; Hubert J; Reynaud R; Lanthony S; Harakat D; Renault JH; Nuzillard JM
[Ad] Endereço:Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, SFR CAP'SANTE, Université de Reims Champagne-Ardenne , Reims 51097, France.
[Ti] Título:Computer-Aided C NMR Chemical Profiling of Crude Natural Extracts without Fractionation.
[So] Source:J Nat Prod;80(5):1387-1396, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A computer-aided, C NMR-based dereplication method is presented for the chemical profiling of natural extracts without any fractionation. An algorithm was developed in order to compare the C NMR chemical shifts obtained from a single routine spectrum with a set of predicted NMR data stored in a natural metabolite database. The algorithm evaluates the quality of the matching between experimental and predicted data by calculating a score function and returns the list of metabolites that are most likely to be present in the studied extract. The proof of principle of the method is demonstrated on a crude alkaloid extract obtained from the leaves of Peumus boldus, resulting in the identification of eight alkaloids, including isocorydine, rogersine, boldine, reticuline, coclaurine, laurotetanine, N-methylcoclaurine, and norisocorydine, as well as three monoterpenes, namely, p-cymene, eucalyptol, and α-terpinene. The results were compared to those obtained with other methods, either involving a fractionation step before the chemical profiling process or using mass spectrometry detection in the infusion mode or coupled to gas chromatography.
[Mh] Termos MeSH primário: Alcaloides/análise
Aporfinas/química
Espectroscopia de Ressonância Magnética Nuclear de Carbono-13/métodos
Monoterpenos/análise
Monoterpenos/química
Peumus/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Alcaloides/química
Espectrometria de Massas
Estrutura Molecular
Extratos Vegetais/análise
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Aporphines); 0 (Monoterpenes); 0 (Plant Extracts); 1G1C8T1N7Q (4-cymene); 3B5E87JEOX (isocorydine); 4YGF4PQP49 (gamma-terpinene); SDW3N623LN (laurotetanine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b01063


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[PMID]:28304234
[Au] Autor:Carmona ER; Reyes-Díaz M; Parodi J; Inostroza-Blancheteau C
[Ad] Endereço:a Núcleo de Investigación en Bioproductos y Materiales Avanzados (BioMA), Facultad de Ingeniería , Universidad Católica de Temuco , Temuco , Chile.
[Ti] Título:Antimutagenic evaluation of traditional medicinal plants from South America Peumus boldus and Cryptocarya alba using Drosophila melanogaster.
[So] Source:J Toxicol Environ Health A;80(4):208-217, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Peumus boldus Mol. ("Boldo") and Cryptocarya alba Mol. Looser ("Peumo") are medicinal shrubs with wide geographical distribution in South America. Their leaves and fruits are commonly used in traditional medicine because they exhibit natural medicinal properties for treatment of liver disorders and rheumatism. However, there are no apparent data regarding potential protective effects on cellular genetic components. In order to examine potential mutagenic and/or antimutagenic effects of these medicinal plants, the Drosophila melanogaster (D. melanogaster) wing-spot test was employed. This assay detects a wide range of mutational events, including point mutations, deletions, certain types of chromosomal aberrations (nondisjunction), and mitotic recombination. Qualitative and quantitative analyses of phenolic and anthocyanin compounds were carried out using biochemical and high-performance liquid chromatography methodologies. In addition, the antioxidant capacity of P. boldus and C. alba leaf extracts was also analyzed. P. boldus and C. alba extracts did not induce significant mutagenic effects in the D. melanogaster model. However, simultaneous treatment of extracts concurrently with the mutagen ethyl methane sulphonate showed a decrease of mutant spots in somatic cells of D. melanogaster, indicating desmutagenic effects in this in vivo model. Flavonoids and anthocyanins were detected predominantly in the extracts, and these compounds exerted significant antioxidant capacity. The observed antimutagenic effects may be related to the presence of phytochemicals with high antioxidant capacity, such as flavonoids and antohocyanins, in the extracts.
[Mh] Termos MeSH primário: Antimutagênicos/farmacologia
Cryptocarya/química
Drosophila melanogaster/efeitos dos fármacos
Peumus/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Antocianinas/análise
Antocianinas/farmacologia
Antioxidantes/análise
Antioxidantes/farmacologia
Chile
Drosophila melanogaster/crescimento & desenvolvimento
Metanossulfonato de Etila/metabolismo
Larva/efeitos dos fármacos
Mutagênicos/metabolismo
Fenóis/análise
Fenóis/farmacologia
Extratos Vegetais/química
Folhas de Planta/química
Asas de Animais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antimutagenic Agents); 0 (Antioxidants); 0 (Mutagens); 0 (Phenols); 0 (Plant Extracts); 9H154DI0UP (Ethyl Methanesulfonate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1279574


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[PMID]:27576017
[Au] Autor:Ribeiro RJ; Silvestre C; Duarte C
[Ad] Endereço:a Hospital Prof. Doutor Fernando Fonseca, EPE, Medicina III , Amadora , Portugal.
[Ti] Título:Hidden Risks of Alternative Medicines: A Case of Boldo-Induced Hepatotoxicity.
[So] Source:J Diet Suppl;14(2):186-190, 2017 Mar 04.
[Is] ISSN:1939-022X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The alternative medicines are commonly used, especially herbal ones. Among them, boldo is traditionally used for symptomatic treatment of dyspepsia and mild gastrointestinal spasmodic disorders. Nevertheless, the number of reported cases of possible hepatotoxicity of some of these products has increased, including one report of boldo-induced hepatitis. We present the case of a 72-year-old female patient who has developed jaundice and increased serum levels of liver enzymes, after repeated consumption of boldo leaves infusion, during 2 weeks. After exclusion of common causes of hepatobiliary pathology, boldo-induced hepatotoxicity was considered probable. Interrupting of ingestion led to clinical and laboratorial recovery. This case proves the value of research in the alternative medicines' use. Ingestion of boldo, particularly in elderly patients with biliary tract disorders, may be the cause of otherwise unexplained jaundice or abnormal values of liver enzymes.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/complicações
Terapias Complementares/efeitos adversos
Icterícia/induzido quimicamente
Peumus/envenenamento
Folhas de Planta/envenenamento
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170405
[Lr] Data última revisão:
170405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160831
[St] Status:MEDLINE


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Alves, Stenio Nunes
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[PMID]:27815127
[Au] Autor:de Castro DS; da Silva DB; Tibúrcio JD; Sobral ME; Ferraz V; Taranto AG; Serrão JE; de Siqueira JM; Alves SN
[Ad] Endereço:Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del Rei, Divinópolis, MG, Brazil.
[Ti] Título:Larvicidal activity of essential oil of Peumus boldus Molina and its ascaridole-enriched fraction against Culex quinquefasciatus.
[So] Source:Exp Parasitol;171:84-90, 2016 Dec.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Culex quinquefasciatus (Say, 1823), known as the domestic mosquito, is a common and abundant species throughout the world, and a cosmopolitan species. The adults of this mosquito are important in terms of public and animal health since they display adaptability to different hosts. In humans, they are responsible for the transmission of various diseases. One manner of control of this vector is the use of insecticidal or larvicidal products, which may have the drawback of toxicity to mammals and can be harmful to the environment. The present work evaluated the larvicidal potential of the essential oil (EO) and ascaridole-enriched fraction (EF4-5) obtained from the leaves of Peumus boldus Molina (boldo). The EO, obtained by steam distillation, was analyzed by GC/MS and fractionated on silica gel. EO and EF4-5, containing 31.4% and 89.5% ascaridole, respectively, were evaluated against C. quinquefasciatus at concentrations of 100, 50 and 25 µg/ml on the third and fourth instars. They showed lethal concentrations (LC ) of 82.14 and 41.85 µg/ml, respectively. Larvae treated with the EF4-5 showed morphological changes in the midgut, with cells possessing a cytoplasm that contained small vacuole-like structures, as well as a nucleus with decondensed chromatin and a cell apex with a short brush border. The cells of the fat body showed larger protein granules, which were acidophilic relative to the larvae of the control group. Moreover, the enriched fraction at a dose of 50 µg/ml showed a residual larvicidal effect according to exposure time on C. quinquefasciatus. This residual effect deserves consideration, since a long-term larvicidal product may be a useful tool for vector control.
[Mh] Termos MeSH primário: Culex/efeitos dos fármacos
Monoterpenos/química
Óleos Voláteis/farmacologia
Peróxidos/química
Peumus/química
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa-Espectrometria de Massas
Larva/efeitos dos fármacos
Dose Letal Mediana
Espectroscopia de Ressonância Magnética
Monoterpenos/farmacologia
Óleos Voláteis/química
Peróxidos/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Oils, Volatile); 0 (Peroxides); 0 (Plant Extracts); 1718D0GEVJ (ascaridole)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170112
[Lr] Data última revisão:
170112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


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Lima, Sonia Oliveira
Texto completo SciELO Brasil
[PMID]:27737346
[Au] Autor:Figueiredo MB; Santana VR; Nardelli MJ; Nogueira MS; Azevedo DX; Santana DP; Figueiredo AG; Duarte ÍX; Albuquerque RL; Lima SO
[Ad] Endereço:Master, Postgraduate Program in Health and Environment, Department of Morphology and Structural Biology, Universidade Tiradentes (UNIT), Aracaju-SE, Brazil. Scientific and intellectual content of the study; conception and design of the study; acquisition, analysis and interpretation of data; technic
[Ti] Título:The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy.
[So] Source:Acta Cir Bras;31(9):608-614, 2016 Sep.
[Is] ISSN:1678-2674
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:PURPOSE:: To assess the effect of aqueous extract of Peumus Boldus (AEPB) on the liver proliferative response after parcial hepatectomy of 70% (PH) in rodents. METHODS:: Twenty Wistar rats were divided in two groups: AEPB100 (whose rats received 100mg/Kg of AEPB, once a day, orally, in 4 days prior to the first surgical procedure) and Vehicle (whose rats were treated similarly with distilled water). Both groups underwent PH. After 24 hours the remaining livers were removed for studying the proliferation of hepatocytes by Ki-67 and 2mL of blood were collected for serological assessment: cholesterol, glucose, triglycerides, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total, direct and indirect bilirubin. All data were analyzed by Gaussian distribution. Statistically significant differences between mean values were analyzed using T Student's test. Non-Gaussian data were analyzed using Mann-Whitney's test. RESULTS:: The liver of all these rats presented positive staining of Ki-67, indicating liver proliferation. Laboratory results showed no significant difference in serum values between the analyzed groups. The analysis of Ki-67 was significantly more positive in AEPB100 group than in Vehicle group. CONCLUSION:: Aqueous extract of Peumus Boldus acute administration exerts significant positive effect on liver regeneration after 24h in rats that underwent parcial hepatectomy, while maintaining unchanged hepatic function.
[Mh] Termos MeSH primário: Hepatectomia/métodos
Hepatócitos/efeitos dos fármacos
Regeneração Hepática/efeitos dos fármacos
Fígado/fisiologia
Peumus/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Feminino
Hepatócitos/metabolismo
Fígado/efeitos dos fármacos
Folhas de Planta/química
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE


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[PMID]:27350578
[Au] Autor:Bianchini MC; Gularte CO; Escoto DF; Pereira G; Gayer MC; Roehrs R; Soares FA; Puntel RL
[Ad] Endereço:Universidade Federal do Pampa, Campus Uruguaiana, BR-472 Km 7, Uruguaiana, RS, CEP 97500-970, Brazil.
[Ti] Título:Peumus boldus (Boldo) Aqueous Extract Present Better Protective Effect than Boldine Against Manganese-Induced Toxicity in D. melanogaster.
[So] Source:Neurochem Res;41(10):2699-2707, 2016 Oct.
[Is] ISSN:1573-6903
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The cellular, intracellular and molecular mechanism(s) underlying the toxicity of Mn are still incompletely understood, although several points concerning Mn neurotoxicity have been addressed. Importantly, oxidative changes have been reported to be involved in Mn-induced toxicity. As a consequence, antioxidants are expected to offer protection in Drosophila melanogaster exposed to this metal. So, in this study we evaluated the hypothesis that the aqueous extract of boldo (Peumus boldus), and its alkaloids boldine, could prevent/ameliorate behavioral and oxidative alterations induced by Mn in a D. melanogaster intoxication model. Adult wild-type flies were concomitantly exposed to Mn (3 mM) and boldo aqueous extract (5 mg/mL) or boldine (327.37 µg/mL) in the food during 9 days. Mn-fed flies had a worse performance in the negative geotaxis assay and in the open-field test, as well as a higher incidence of mortality and TBARS levels in head and body, when compared to control group. Boldo aqueous extract was found to reduce the mortality rate of the flies exposed to Mn. In turn, boldine was ineffective against Mn-induced mortality and significantly increases mortality per se. Additionally, Mn-induced locomotors dysfunction were fully ameliorated by boldo crude extract and only partially ameliorated by boldine. Likewise, boldo completely normalize head and body TBARS levels, whereas boldine only partially normalize in body. Finally, we found that flies treated with Mn presented significantly decrease in dopamine levels. Our results suggest that boldo crude extract can exert protective effect against Mn-induced toxicity in D. melanogaster, whereas boldine do not. Moreover, our data confirm the utility of this model to investigate potential therapeutic strategies on movement disorders, such as that caused by Mn.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Oxirredução/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Peumus/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Aporfinas/farmacologia
Drosophila melanogaster/efeitos dos fármacos
Manganês/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Aporphines); 0 (Plant Extracts); 42Z2K6ZL8P (Manganese); 8I91GE2769 (boldine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE


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[PMID]:25973480
[Au] Autor:Host'álková A; Opletal L; Kunes J; Novák Z; Hrabinová M; Chlebek J; Cegan L; Cahlíková L
[Ti] Título:Alkaloids from Peumus boldus and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity.
[So] Source:Nat Prod Commun;10(4):577-80, 2015 Apr.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eleven isoquinoline alkaloids (1-11) were isolated from dried leaves of Peumus boldus Mol. by standard chromatographic methods. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic analysis, and by comparison with literature data. Compounds isolated in sufficient amount were evaluated for their acetylcholinesterase, and butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro-p-nitroanilide was used as substrate. Promising butyrylcholinesterase inhibition activities were demonstrated by two benzylisoquinoline alkaloids, reticuline (8) and N-methylcoclaurine (9), with IC50 values of 33.6 ± 3.0 µM and 15.0 ± 1.4 µM, respectively. Important prolyl oligopeptidase inhibition activities were shown by N-methyllaurotetanine (6) and sinoacutine (4) with IC50 values of 135.4 ± 23.2 µM and 143.1 ± 25.4 µM, respectively. Other tested compounds were considered inactive.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Alcaloides/química
Alcaloides/farmacologia
Butirilcolinesterase/metabolismo
Inibidores da Colinesterase/farmacologia
Peumus/química
Serina Endopeptidases/metabolismo
[Mh] Termos MeSH secundário: Inibidores da Colinesterase/química
Seres Humanos
Folhas de Planta/química
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Cholinesterase Inhibitors); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); EC 3.4.21.- (Serine Endopeptidases); EC 3.4.21.26 (prolyl oligopeptidase)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150515
[St] Status:MEDLINE


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[PMID]:25636882
[Au] Autor:Villiger A; Sala F; Suter A; Butterweck V
[Ad] Endereço:Institute for Pharma Technology, School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland.
[Ti] Título:In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome.
[So] Source:Phytomedicine;22(1):138-44, 2015 Jan 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Boldocynara®, a proprietary dietary supplement product consisting of the plants Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus, used to promote functions of the liver and the gallbladder. It was the aim of the present study to look from a different perspective at the product by investigating the in vitro potential of Boldocynara® as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome. Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml). Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 µg/ml) whereas Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 µg/ml). The combination had moderate to weak effects on the tested enzymes. In conclusion, our results indicate some moderate potential of the dietary supplement Boldocynara® and its single ingredients for the prevention of metabolic disorders.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/química
Síndrome Metabólica/enzimologia
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Inibidores da Enzima Conversora de Angiotensina/química
Cynara scolymus/química
Flavonoides/química
Inibidores de Glicosídeo Hidrolases/química
Lipase/antagonistas & inibidores
Cardo Mariano/química
Peumus/química
Taraxacum/química
Xantina Oxidase/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Enzyme Inhibitors); 0 (Flavonoids); 0 (Glycoside Hydrolase Inhibitors); 0 (Plant Extracts); EC 1.17.3.2 (Xanthine Oxidase); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150201
[St] Status:MEDLINE


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[PMID]:25292342
[Au] Autor:Mondal J; Bishayee K; Panigrahi AK; Khuda-Bukhsh AR
[Ad] Endereço:Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani-741235, India.
[Ti] Título:Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro.
[So] Source:J Integr Med;12(5):425-38, 2014 Sep.
[Is] ISSN:2095-4964
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Use of cisplatin, a conventional anticancer drug, is restricted because it generates strong hepatotoxicity by accumulating in liver. Therefore its anticancer potential can only be fully exploited if its own toxicity is considerably reduced. Towards this goal, ethanolic extract of the plant, Boldo (Peumus boldus), known for its antihepatotoxic effects, was used simultaneously with cisplatin, to test its ability to reduce cisplatin's cytotoxicity without affecting its anticancer potential. METHODS: The cytotoxicity of Boldo extract (BE) and cisplatin, administered alone and in combination, was determined in three cancer cell lines (A549, HeLa, and HepG2) and in normal liver cells (WRL-68). Drug-DNA interaction, DNA damage, cell cycle, apoptosis, reactive oxygen species (ROS) and mitochondrial membrane potential (MMP, ΔΨ) were also studied. Hepatotoxicity and antioxidant activity levels were determined by alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and glutathione assays in mice. The cytotoxicity of related proteins was tested by Western blotting. RESULTS: Co-administration of BE and cisplatin increased viability of normal cells, but had no effect on the viability of cancer cells. Boldo protected liver from damage and normalized different antioxidant enzyme levels in vivo and also reduced ROS and re-polarized MMP in vitro. Bax and cytochrome c translocation was reduced with caspase 3 down-regulation. Further, a drug-DNA interaction study revealed that BE reduced cisplatin's DNA-binding capacity, resulting in a reduction in DNA damage. CONCLUSION: Results indicated that a low dose of BE could be used beneficially in combination with cisplatin to reduce its toxicity without hampering cisplatin's anticancer effect. These findings signify a potential future use of BE in cancer therapy.
[Mh] Termos MeSH primário: Antineoplásicos/toxicidade
Cisplatino/toxicidade
Hepatócitos/efeitos dos fármacos
Neoplasias/tratamento farmacológico
Peumus
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Dano ao DNA
Feminino
Glutationa/metabolismo
Hepatócitos/metabolismo
Hepatócitos/patologia
Seres Humanos
Masculino
Camundongos
Neoplasias/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); GAN16C9B8O (Glutathione); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:141008
[Lr] Data última revisão:
141008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141009
[St] Status:MEDLINE


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Texto completo
[PMID]:25230279
[Au] Autor:Chaboussant PJ; Gagez AL; Graber M; Zhao JM; Chavant F; Perault-Pochat MC; Graber D
[Ad] Endereço:Service de pédiatrie, Hopital Saint-Louis, La Rochelle, France.
[Ti] Título:[Behavioural impairments and hallucinations after consumption of boldo leaf infusions].
[Ti] Título:Troubles du comportement et hallucinations après consommation d'infusions de feuilles de boldo..
[So] Source:Therapie;69(5):465-7, 2014 Sep-Oct.
[Is] ISSN:0040-5957
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:We report a case of behavioural impairments with hallucinations in a twelve-year-old girl, after consumption of boldo leaf infusions. The main alkaloid of boldo, named boldine, is very likely responsible for temporary neuropsychiatric disturbances present in the patient. The emergence of behavioural problems and hallucinations without any obvious cause, should lead to search for consumption of boldo leaf infusion ("tisanes"). This consumption must be avoided in children.
[Mh] Termos MeSH primário: Transtornos do Comportamento Infantil/induzido quimicamente
Alucinações/induzido quimicamente
Peumus/efeitos adversos
Preparações de Plantas/efeitos adversos
[Mh] Termos MeSH secundário: Acatisia Induzida por Medicamentos/diagnóstico
Criança
Transtornos do Comportamento Infantil/diagnóstico
Feminino
Alucinações/diagnóstico
Seres Humanos
Folhas de Planta
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; LETTER
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:141007
[Lr] Data última revisão:
141007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140918
[St] Status:MEDLINE
[do] DOI:10.2515/therapie/2014052



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