Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.100.050 [Categoria DeCS]
Referências encontradas : 21 [refinar]
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  1 / 21 MEDLINE  
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[PMID]:28898076
[Au] Autor:Zhan G; Zhou J; Liu J; Huang J; Zhang H; Liu R; Yao G
[Ad] Endereço:Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China.
[Ti] Título:Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata.
[So] Source:J Nat Prod;80(9):2462-2471, 2017 Sep 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eleven new alkaloids (1-11), classified as the 12-acetylplicamine (1), N-deformyl-seco-plicamine (2), plicamine (3-6), 4a-epi-plicamine (7), seco-plicamine (8), and lycorine (9-11) framework types, along with 15 known alkaloids (12-26) were isolated from the whole plants of Zephyranthes carinata. The structures of the new alkaloids 1-11 were established by extensive spectroscopic data interpretation. The absolute configurations of 9 and 10 were defined by single-crystal X-ray diffraction analysis. Zephycarinatines A (1), B (2), and G (7) represent the first examples of 12-acetylplicamine, N-deformyl-seco-plicamine, and 4a-epi-plicamine alkaloids, respectively. Alkaloids 6, 11, 17, and 20-23 exhibited AChE inhibitory activities with IC values ranging from 1.21 to 184.05 µM, and a preliminary structure-activity relationship is discussed.
[Mh] Termos MeSH primário: Acetilcolinesterase/isolamento & purificação
Acetilcolinesterase/metabolismo
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Alcaloides de Amaryllidaceae/isolamento & purificação
Alcaloides de Amaryllidaceae/farmacologia
Amaryllidaceae/química
Inibidores da Colinesterase/isolamento & purificação
Inibidores da Colinesterase/farmacologia
Compostos Heterocíclicos de 4 ou mais Anéis/isolamento & purificação
Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia
Liliaceae/química
Fenantridinas/isolamento & purificação
Fenantridinas/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/química
Alcaloides/química
Alcaloides de Amaryllidaceae/química
Inibidores da Colinesterase/química
Compostos Heterocíclicos de 4 ou mais Anéis/química
Concentração Inibidora 50
Estrutura Molecular
Fenantridinas/química
Relação Estrutura-Atividade
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Amaryllidaceae Alkaloids); 0 (Cholinesterase Inhibitors); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Phenanthridines); 0 (Zephycarinatine G); 0 (plicamine); 0 (zephycarinatine A); 0 (zephycarinatine B); EC 3.1.1.7 (Acetylcholinesterase); I9Q105R5BU (lycorine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00301


  2 / 21 MEDLINE  
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[PMID]:28756149
[Au] Autor:Havelek R; Muthna D; Tomsik P; Kralovec K; Seifrtova M; Cahlikova L; Hostalkova A; Safratova M; Perwein M; Cermakova E; Rezacova M
[Ad] Endereço:Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, Hradec Kralove 500 03, Czech Republic. Electronic address: havelekr@lfhk.cuni.cz.
[Ti] Título:Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.
[So] Source:Chem Biol Interact;275:121-132, 2017 Sep 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In this study, twenty-two Amaryllidaceae alkaloids were screened for their anticancer potential. All isolates were evaluated for antiproliferative activities on a panel of 17 human cell types of different tissue origin using WST-1 assay. In addition, we determined the antiproliferative effect with a real-time cell analysis xCELLigence system. Thereafter, to evaluate the barely known in vivo anticancer potential of the most potent molecule haemanthamine, a preliminary study was performed using an Ehrlich tumor-bearing mice model. The results showed that haemanthamine, lycorine and haemanthidine exerted the highest antiproliferative activity. The mean growth percent (GP) value after a single-dose 10 µM treatment was for haemanthamine 21%, for lycorine 21% and for haemanthidine 27% that of untreated control cells (100%). Furthermore, haemanthamine, lycorine and haemanthidine exhibited significant cytotoxicities against all the tested cell lines with individual IC values in the micromolar range. Dynamic real-time measures of impedance by xCELLigence indicated that these three compounds suppress cell proliferation after 10 h of treatment at a concentration of 10 µM or higher. Regrettably, in a follow-up in vivo antitumor activity study, haemanthamine showed no statistically significant reduction in the tumor size with no prolongation of survival time of Ehrlich tumor-bearing mice. Taken together, these results provide a new clue and guidance for exploiting Amaryllidaceae alkaloids as anticancer agents.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Amaryllidaceae/química
Apoptose/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/uso terapêutico
Amaryllidaceae/metabolismo
Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Antineoplásicos Fitogênicos/uso terapêutico
Carcinoma de Ehrlich/tratamento farmacológico
Carcinoma de Ehrlich/mortalidade
Carcinoma de Ehrlich/patologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Camundongos
Transplante Heterólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE


  3 / 21 MEDLINE  
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[PMID]:28418749
[Au] Autor:Rodríguez-Domínguez JM; Ríos-Lara LL; Tapia-Campos E; Barba-Gonzalez R
[Ad] Endereço:a Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco , A.C. Unidad de Biotecnología Vegetal , Guadalajara , Jalisco , México.
[Ti] Título:An improved technique for obtaining well-spread metaphases from plants with numerous large chromosomes.
[So] Source:Biotech Histochem;92(3):159-166, 2017.
[Is] ISSN:1473-7760
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Preparations that contain well-spread metaphase chromosomes are critical for plant cytogenetic analyses including chromosome counts, banding procedures, in situ hybridization, karyotyping and construction of ideograms. Chromosome spreading is difficult for plants with large and numerous chromosomes. We report here a technique for obtaining cytoplasm-free, well-spread metaphases from two Amaryllidaceae species: Sprekelia formosissima (2n = 120) and Hymenocallis howardii (2n = 96). The technique has three main steps: 1) pretreatment to cause chromosome condensation, 2) dripping onto tilted slides coated with a thin layer of pure acetic acid and 3) application of steam and acetic acid to produce cytoplasmic hydrolysis, which spreads the chromosomes.
[Mh] Termos MeSH primário: Amaryllidaceae/citologia
Amaryllidaceae/genética
Cromossomos/genética
Técnicas Citológicas/métodos
Metáfase
Raízes de Plantas/citologia
[Mh] Termos MeSH secundário: Segregação de Cromossomos
Mitose
Raízes de Plantas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1080/10520295.2017.1288927


  4 / 21 MEDLINE  
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[PMID]:28390909
[Au] Autor:García N; Folk RA; Meerow AW; Chamala S; Gitzendanner MA; Oliveira RS; Soltis DE; Soltis PS
[Ad] Endereço:Facultad de Ciencias Forestales y de la Conservación de la Naturaleza, Universidad de Chile, Av. Santa Rosa 11315, La Pintana, Santiago, Chile; Florida Museum of Natural History, University of Florida, Gainesville, FL 32611, USA. Electronic address: nicogarciab@gmail.com.
[Ti] Título:Deep reticulation and incomplete lineage sorting obscure the diploid phylogeny of rain-lilies and allies (Amaryllidaceae tribe Hippeastreae).
[So] Source:Mol Phylogenet Evol;111:231-247, 2017 Jun.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hybridization is a frequent and important force in plant evolution. Next-generation sequencing (NGS) methods offer new possibilities for clade resolution and ambitious sampling of gene genealogies, yet difficulty remains in detecting deep reticulation events using currently available methods. We reconstructed the phylogeny of diploid representatives of Amaryllidaceae tribe Hippeastreae to test the hypothesis of ancient hybridizations preceding the radiation of its major subclade, Hippeastrinae. Through hybrid enrichment of DNA libraries and NGS, we obtained data for 18 nuclear loci through a curated assembly approach and nearly complete plastid genomes for 35 ingroup taxa plus 5 outgroups. Additionally, we obtained alignments for 39 loci through an automated assembly algorithm. These data were analyzed with diverse phylogenetic methods, including concatenation, coalescence-based species tree estimation, Bayesian concordance analysis, and network reconstructions, to provide insights into the evolutionary relationships of Hippeastreae. Causes for gene tree heterogeneity and cytonuclear discordance were examined through a Bayesian posterior predictive approach (JML) and coalescent simulations. Two major clades were found, Hippeastrinae and Traubiinae, as previously reported. Our results suggest the presence of two major nuclear lineages in Hippeastrinae characterized by different chromosome numbers: (1) Tocantinia and Hippeastrum with 2n=22, and (2) Eithea, Habranthus, Rhodophiala, and Zephyranthes mostly with 2n=12, 14, and 18. Strong cytonuclear discordance was confirmed in Hippeastrinae, and a network scenario with at least six hybridization events is proposed to reconcile nuclear and plastid signals, along a backbone that may also have been affected by incomplete lineage sorting at the base of each major subclade.
[Mh] Termos MeSH primário: Amaryllidaceae/anatomia & histologia
Amaryllidaceae/classificação
Diploide
Filogenia
[Mh] Termos MeSH secundário: Teorema de Bayes
Núcleo Celular/genética
Simulação por Computador
Loci Gênicos
Seres Humanos
Hibridização Genética
Funções Verossimilhança
Plastídeos/genética
Alinhamento de Sequência
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


  5 / 21 MEDLINE  
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[PMID]:28161967
[Au] Autor:Li Q; Xu Y; Zhu M; Dong Y; Hu J; Li Y; Liu Y
[Ti] Título:Genetic diversity of the nucleocapsid protein gene of hippeastrum chlorotic ringspot virus from Hymenocallis littoralis in southern China.
[So] Source:Acta Virol;61(1):116-122, 2017.
[Is] ISSN:0001-723X
[Cp] País de publicação:Slovakia
[La] Idioma:eng
[Ab] Resumo:Hymenocallis littoralis growing in southern China has been recently extensively damaged by virus-like symptoms of necrosis, chlorosis, and ringspot. Of 44 plant samples collected from Yunnan, Guangxi, Guangdong, and Fujian provinces in southern China, 32 were infected with hippeastrum chlorotic ringspot virus (HCRV). Phylogenetic analysis based on the N gene divided the virus samples into two branches suggesting a geographic distribution attributed to the initial stage of a founder effect. The N gene was under purifying selection pressure and most of the deleterious mutants had been removed. Both the population dynamics and genetic analyses suggested that populations of HCRV in southern China are spreading.
[Mh] Termos MeSH primário: Amaryllidaceae/virologia
Variação Genética
Proteínas do Nucleocapsídeo/genética
Vírus de Plantas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nucleocapsid Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.4149/av_2017_01_120


  6 / 21 MEDLINE  
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[PMID]:27864138
[Au] Autor:Masi M; van der Westhuyzen AE; Tabanca N; Evidente M; Cimmino A; Green IR; Bernier UR; Becnel JJ; Bloomquist JR; van Otterlo WA; Evidente A
[Ad] Endereço:Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy.
[Ti] Título:Sarniensine, a mesembrine-type alkaloid isolated from Nerine sarniensis, an indigenous South African Amaryllidaceae, with larvicidal and adulticidal activities against Aedes aegypti.
[So] Source:Fitoterapia;116:34-38, 2017 Jan.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A new mesembrine-type alkaloid, named sarniensine, was isolated together with tazettine, lycorine, the main alkaloid, and 3-epimacronine from Nerine sarniensis, with the last two produced for the first time by this plant. This Amaryllidaceae, which is indigenous of South Africa, was investigated for its alkaloid content, because the organic extract of its bulbs showed strong larvicidal activity with an LC value of 0.008µgµL against first instar Aedes aegypti larvae and with an LD value 4.6µg/mosquito against adult female Ae. aegypti, which is the major vector for dengue, yellow fever and the Zika virus. The extract did not show repellency at MED value of 0.375mgcm against adult Ae. aegypti. Sarniensine was characterized using spectroscopic and chiroptical methods as (3aR,4Z,6S,7aS)-6-methoxy-3a-(2'-methoxymethyl-benzo [1,3]dioxol-1'-yl)-1-methyl-2,3,3a,6,7,7a-hexahydro-1H-indole. It was less effective against larva at the lowest concentration of 0.1µgµL , however it showed strong adulticidal activity with an LD value of 1.38±0.056µgmosquito .
[Mh] Termos MeSH primário: Aedes
Amaryllidaceae/química
Alcaloides de Indol/química
Inseticidas/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Alcaloides de Amaryllidaceae/química
Alcaloides de Amaryllidaceae/isolamento & purificação
Animais
Alcaloides de Indol/isolamento & purificação
Inseticidas/isolamento & purificação
Larva
Estrutura Molecular
Fenantridinas/química
Fenantridinas/isolamento & purificação
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-epimacronine); 0 (Amaryllidaceae Alkaloids); 0 (Indole Alkaloids); 0 (Insecticides); 0 (Phenanthridines); 0 (Plant Extracts); 0 (sarniensine); 76WEU12CSO (tazettine); 86E2ZU4ETY (mesembrine); I9Q105R5BU (lycorine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


  7 / 21 MEDLINE  
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[PMID]:27823880
[Au] Autor:Zhan G; Liu J; Zhou J; Sun B; Aisa HA; Yao G
[Ad] Endereço:Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
[Ti] Título:Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors.
[So] Source:Eur J Med Chem;127:771-780, 2017 Feb 15.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Three new Amaryllidaceae alkaloids, named zephycandidines I-III (1-3), were isolated from Zephyranthes candida. The structures of 1-3 were elucidated by spectroscopic analyses including HRESIMS, H NMR, C NMR, DEPT, HSQC, H- H COSY, HMBC, ROESY, and electronic circular dichroism (ECD), as well as ECD calculation. The absolute configuration of 1 was finally established by single crystal X-ray diffraction using Cu Kα radiation. Zephycandidines I (1) and III (3) with new framework types represent the first example of 7-phenyl-hexahydroindole and 5,2'-dimethyl-biphenyl-2-ylamine alkaloids, respectively, and their plausible biosynthetic pathway are proposed. Zephycandidine II (2) is the first C3a-phenyl-hexahydroindole type alkaloid isolated from the genus of Zephyranthes. These new alkaloids 1-3 were evaluated for their acetylcholinesterase (AChE) inhibitory activities, and 3 showed potent AChE inhibitory activity with an IC value of 8.82 µM, suggesting that the framework of 5,2'-dimethyl-biphenyl-2-ylamine in 3 may be a potential group for the AChE inhibitory activity. The docking studies of 1-3 and galanthamine with AChE revealed that interactions with W286 and Y337 are necessary for the AChE inhibitory activity.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Alcaloides de Amaryllidaceae/farmacologia
Amaryllidaceae/química
Inibidores da Colinesterase/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/química
Alcaloides de Amaryllidaceae/química
Alcaloides de Amaryllidaceae/metabolismo
Animais
Inibidores da Colinesterase/química
Inibidores da Colinesterase/metabolismo
Electrophorus
Simulação de Acoplamento Molecular
Conformação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amaryllidaceae Alkaloids); 0 (Cholinesterase Inhibitors); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


  8 / 21 MEDLINE  
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[PMID]:27558679
[Au] Autor:Hotchandani T; Desgagne-Penix I
[Ti] Título:Heterocyclic Amaryllidaceae Alkaloids: Biosynthesis and Pharmacological Applications.
[So] Source:Curr Top Med Chem;17(4):418-427, 2017.
[Is] ISSN:1873-4294
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Amaryllidaceae alkaloids (AAs), which are natural heterocyclic compounds, are isolated from Amaryllidaceae plants such as narcissus, snowdrop and spider lily. AAs have been extensively studied due to their multiple pharmacological properties. Nevertheless, knowledge of AA synthesis in plants is lacking and most genes encoding enzymes involved in their production remain unknown. AAs are structurally complex compounds which are challenging for total chemical synthesis that is economically viable. Therefore the understanding of AA biosynthesis could allow for the development of biotechnologies for the production of natural AAs or analogues, maintaining or improving their pharmacological properties. In this review, we describe the progress regarding the biosynthesis and pharmacological properties of AAs. The most recent developments in neurological, anti-cancer and anti-microbial bioactivities of heterocyclic AAs are covered.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Amaryllidaceae/química
Compostos Heterocíclicos/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/efeitos adversos
Alcaloides/biossíntese
Alcaloides/química
Compostos Heterocíclicos/efeitos adversos
Compostos Heterocíclicos/química
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Heterocyclic Compounds)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160826
[St] Status:MEDLINE


  9 / 21 MEDLINE  
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[PMID]:27460470
[Au] Autor:Tütüncü Konyar S
[Ad] Endereço:Department of Biology, Faculty of Science, Trakya University, 22030, Edirne, Turkey. seviltutuncu@gmail.com.
[Ti] Título:Ultrastructural aspects of pollen ontogeny in an endangered plant species, Pancratium maritimum L. (Amaryllidaceae).
[So] Source:Protoplasma;254(2):881-900, 2017 Mar.
[Is] ISSN:1615-6102
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Pollen ontogeny in Pancratium maritimum L. was studied from the sporogenous cell to mature pollen grain stages using transmission electron, scanning electron, and light microscopy to determine whether the pollen development in P. maritimum follows the basic scheme in angiosperms or not. In the course of microsporogenesis and microgametogenesis, special attention was given to the considerable ultrastructural changes that are observed in the cytoplasm of microsporocytes, microspores, and mature pollen grains throughout the successive stages of pollen development. Microsporocyte differentiation concerning number and ultrastructure of organelles facilitates the transition of microsporocytes from the sporophytic phase to the gametophytic phase. However, cytoplasmic differentiation of generative and vegetative cells supports their functional distinctness and pollen maturation. Although microsporogenesis and microgametogenesis in P. maritimum generally follow the usual angiosperm pattern, abnormalities such as formation of unreduced gametes were observed. During normal microsporogenesis, meiocytes undergo meiosis and successive cytokinesis, resulting in the formation of isobilateral, decussate, and linear tetrads. Subsequent to the development of free and vacuolated microspores, the first mitotic division occurs and bicellular monosulcate pollen grains are produced. Pollen grains are shed from the anther at binucleate stage. During pollen ontogeny, three periods of vacuolization were observed: in meiocytes, in mononucleate free microspores, and in the generative cell.
[Mh] Termos MeSH primário: Amaryllidaceae/ultraestrutura
Espécies em Perigo de Extinção
Pólen/ultraestrutura
[Mh] Termos MeSH secundário: Amaryllidaceae/citologia
Sobrevivência Celular
Gametogênese Vegetal
Meiose
Mitose
Pólen/anatomia & histologia
Pólen/citologia
Vacúolos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160728
[St] Status:MEDLINE
[do] DOI:10.1007/s00709-016-0998-3


  10 / 21 MEDLINE  
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[PMID]:28852727
[Au] Autor:Moodley K; Mackraj I
[Ad] Endereço:Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
[Ti] Título:METABOLIC EFFECTS OF HARV. IN A DIABETIC MODEL.
[So] Source:Afr J Tradit Complement Altern Med;13(4):113-122, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes mellitus (DM) is a cluster of metabolic diseases with chronic hyperglycemia as a defining feature, associated with long-term organ damage and dysfunction. In this study we examined the effect of rhizome methanolic extract on blood glucose and lipids in normal and streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Male Wistar rats (250-300g) were injected intraperitoneally (i.p.) with streptozotocin (60mg/kg body weight) to induce diabetes; or provided with distilled water for the control (CON) (3 ml/kg/b.w.) animals and treatment with TVL (60mg/kg.b.w). The rats were divided into 5 groups of 6 animals per group as follows: Non-diabetic control (NDC)-received distilled water (3ml/kg.b.w), Non-diabetic TVL (ND+TVL)-received TVL (60mh/kg b.w), Diabetic control (DC)-received distilled water (3ml/kg.b.w), Diabetic experimental (D+TVL)-received TVL (60mg/kg.b.w), Diabetic experimental (D+M)-received Metformin (250 mg/kg.b.w). All doses were administered daily via oral gavage. RESULTS: TVL-treated animals showed reduced blood glucose, increased plasma insulin, reduced plasma TG, TC, VLDL and increased HDL. Furthermore we found decreased thiobarbituric acid reactive substances (TBARS) and increased superoxide dismutase (SOD) activity and nitric oxide significantly. Regarding renal parameters we found increased blood urea nitrogen (BUN), and improved renal morphology in TVL-treated animals. CONCLUSION: has a hypoglycaemic effect which could due to its effects on multiple pathways of the hyperglycemic process. Further work is needed to identify the mechanism of its antidiabetic effect.
[Mh] Termos MeSH primário: Amaryllidaceae/química
Diabetes Mellitus/tratamento farmacológico
Hipoglicemiantes/administração & dosagem
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Diabetes Mellitus/metabolismo
Seres Humanos
Insulina/metabolismo
Masculino
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Wistar
Superóxido Dismutase/metabolismo
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts); 0 (Thiobarbituric Acid Reactive Substances); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i4.16



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